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Cheap flights from St. Louis to South Carolina from $79

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to South Carolina departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
4:51 pm - 8:03 am
STL
-
CLT
14h 12m
1 stop
Frontier Logo
7:48 pm - 7:37 am
CLT
-
STL
12h 49m
1 stop
$151Frontier
Tue, Mar 10 - Tue, Mar 17
Frontier Logo
3:49 pm - 8:43 am
STL
-
CLT
15h 54m
1 stop
Frontier Logo
2:46 pm - 10:27 pm
CLT
-
STL
8h 41m
1 stop
$171Frontier
Sat, Feb 28 - Wed, Mar 4
Multiple Airlines Logo
4:51 pm - 8:03 am
STL
-
CLT
14h 12m
1 stop
Multiple Airlines Logo
9:00 pm - 10:37 am
CLT
-
STL
14h 37m
2 stops
$180Multiple Airlines
Tue, Mar 10 - Tue, Mar 17
American Airlines Logo
2:37 pm - 10:48 pm
STL
-
SAV
7h 11m
1 stop
American Airlines Logo
6:25 am - 9:40 am
SAV
-
STL
4h 15m
1 stop
$187American Airlines
Tue, Mar 24 - Tue, Mar 31
American Airlines Logo
5:21 pm - 10:59 pm
STL
-
CHS
4h 38m
1 stop
American Airlines Logo
7:15 am - 11:45 am
CHS
-
STL
5h 30m
1 stop
$187American Airlines
Mon, Apr 20 - Fri, Apr 24
Multiple Airlines Logo
1:09 pm - 8:26 am
STL
-
CLT
18h 17m
2 stops
Multiple Airlines Logo
9:28 pm - 11:19 pm
CLT
-
STL
26h 51m
1 stop
$190Multiple Airlines
Fri, Mar 6 - Mon, Mar 9
Delta Logo
6:00 am - 1:17 pm
STL
-
SAV
6h 17m
1 stop
Delta Logo
5:30 am - 8:18 am
SAV
-
STL
3h 48m
1 stop
$197Delta
Sat, May 2 - Fri, May 8
Delta Logo
5:30 pm - 11:38 pm
STL
-
MYR
5h 08m
1 stop
Delta Logo
7:50 pm - 11:38 pm
MYR
-
STL
4h 48m
1 stop
$207Delta
Mon, Jul 27 - Fri, Jul 31
Southwest Logo
6:35 am - 1:10 pm
STL
-
GSP
5h 35m
1 stop
Southwest Logo
12:50 pm - 8:00 pm
GSP
-
STL
8h 10m
2 stops
$302Southwest
Wed, Apr 8 - Wed, Apr 15
Southwest Logo
1:45 pm - 9:40 pm
STL
-
GSP
6h 55m
2 stops
Southwest Logo
12:50 pm - 8:00 pm
GSP
-
STL
8h 10m
2 stops
$307Southwest
Wed, Apr 8 - Wed, Apr 15

Frontier flights from St. Louis to South Carolina

Our best Frontier deals on St. Louis to South Carolina flight tickets
Frontier
Mar 10
STL4:51 pmLambert-St Louis
14h 12m
1 stop
CLT8:03 amCharlotte Douglas
Mar 17
CLT7:48 pmCharlotte Douglas
12h 49m
1 stop
STL7:37 amLambert-St Louis
$151
Frontier
Feb 28
STL3:49 pmLambert-St Louis
15h 54m
1 stop
CLT8:43 amCharlotte Douglas
Mar 2
CLT7:44 amCharlotte Douglas
17h 15m
1 stop
STL11:59 pmLambert-St Louis
$171
Frontier
Mar 11
STL11:32 amLambert-St Louis
19h 31m
2 stops
CLT8:03 amCharlotte Douglas
Mar 17
CLT7:48 pmCharlotte Douglas
12h 49m
1 stop
STL7:37 amLambert-St Louis
$174

American Airlines flights from St. Louis to South Carolina

Our best American Airlines deals on St. Louis to South Carolina flight tickets
American Airlines
Jun 10
STL6:12 pmLambert-St Louis
2h 03m
CLT9:15 pmCharlotte Douglas
Aug 22
CLT10:55 pmCharlotte Douglas
2h 00m
STL11:55 pmLambert-St Louis
$133
American Airlines
Apr 20
STL5:21 pmLambert-St Louis
4h 38m
1 stop
CHS10:59 pmCharleston
Apr 24
CHS7:15 amCharleston
5h 30m
1 stop
STL11:45 amLambert-St Louis
$187
American Airlines
Mar 9
STL7:00 amLambert-St Louis
6h 57m
1 stop
CHS2:57 pmCharleston
Mar 15
CHS5:10 amCharleston
4h 25m
1 stop
STL8:35 amLambert-St Louis
$191

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 3/10

4:51 pm-8:03 am

1 stop14h 12m

Charlotte Douglas

Tue 3/17

7:48 pm-7:37 am

1 stop12h 49m

$151

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 2/28

3:49 pm-8:43 am

1 stop15h 54m

Charlotte Douglas

Wed 3/4

2:46 pm-10:27 pm

1 stop8h 41m

$171

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 3/10

4:51 pm-8:03 am

1 stop14h 12m

Charlotte Douglas

Tue 3/17

9:00 pm-10:37 am

2 stops14h 37m

$180

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Tue 3/24

2:37 pm-10:48 pm

1 stop7h 11m

Savannah/Hilton Head

Tue 3/31

6:25 am-9:40 am

1 stop4h 15m

$187

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Mon 4/20

5:21 pm-10:59 pm

1 stop4h 38m

Charleston

Fri 4/24

7:15 am-11:45 am

1 stop5h 30m

$187

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 3/6

1:09 pm-8:26 am

2 stops18h 17m

Charlotte Douglas

Mon 3/9

9:28 pm-11:19 pm

1 stop26h 51m

$190

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Sat 5/2

6:00 am-1:17 pm

1 stop6h 17m

Savannah/Hilton Head

Fri 5/8

5:30 am-8:18 am

1 stop3h 48m

$197

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Mon 7/27

5:30 pm-11:38 pm

1 stop5h 08m

Myrtle Beach Intl

Fri 7/31

7:50 pm-11:38 pm

1 stop4h 48m

$207

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 4/8

6:35 am-1:10 pm

1 stop5h 35m

Greenville

Wed 4/15

12:50 pm-8:00 pm

2 stops8h 10m

$302

St. LouisGreenville

STL - GSP

STLGSP

Lambert-St Louis

Wed 4/8

1:45 pm-9:40 pm

2 stops6h 55m

Greenville

Wed 4/15

12:50 pm-8:00 pm

2 stops8h 10m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from St. Louis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from St. Louis is in August. Flight prices, which tend to average around $319, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from St. Louis during November instead. Flights to South Carolina in November, while not as cheap as those in August, still average around $328.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $487.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest St. Louis to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $364. Try not to purchase tickets at noon because they tend to be around $435. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to South Carolina flight route?

Fly from Lambert-St Louis to Myrtle Beach Intl for the best Lambert-St Louis - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $382 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from St. Louis for as low as $317 on momondo.

What cabin class options are available on Lambert-St Louis to South Carolina flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to South Carolina flights?

You could potentially save up to 50% on your flight if you consider stops on a St. Louis to South Carolina flight.

Cheap St. Louis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to South Carolina

Best Price Found

$216

Fastest flight time

1h 45m

Direct flights

Every day

Airports in South Carolina

57 airports
The best one-way flight to South Carolina from St. Louis in the past 72 hours is $216. The best round-trip flight deal from St. Louis to South Carolina found on momondo in the last 72 hours is $360.
The fastest flight from St. Louis to South Carolina takes 1h 45m
Direct flights go from St. Louis to South Carolina every day.
There are 57 airports in South Carolina. From St. Louis there are direct flights to Myrtle Beach Intl (MYR), Savannah/Hilton Head (SAV), Charlotte Douglas (CLT), Charleston (CHS).
Search flight deals

  • When did momondo last update prices for flights from Lambert-St Louis Airport to South Carolina?

    Prices for flights from Lambert-St Louis Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to South Carolina?

  • How old do you have to be to fly from Lambert-St Louis Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to South Carolina?

Best airlines flying from St. Louis to South Carolina

Compare and see reviews for airlines that fly from St. Louis to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $99Free CancellationRating
6.3
8,451 reviews
Search Spirit Airlines flights
DeltaPriceFrom $99Free CancellationRating
7.9
8,200 reviews
Search Delta flights
American AirlinesPriceFrom $195Free CancellationRating
7.2
11,288 reviews
Search American Airlines flights
SouthwestPriceFrom $274Free CancellationRating
8.0
4,284 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to South Carolina for you.

Can I find flights from St. Louis to South Carolina with flexible booking policies on momondo?

Flights from St. Louis to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to South Carolina?

Once you have performed a search for St. Louis to South Carolina flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of St. Louis to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

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