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Cheap flights from St. Louis to South Carolina from $78

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to South Carolina departing on 1/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to South Carolina

Cheap round-trip flights

Frontier Logo
6:22 pm - 10:42 amSTL-CLT
15h 20m1 stop
Frontier Logo
9:20 pm - 9:40 amCLT-STL
13h 20m1 stop
$179Frontier
Find Deal
Thu, Nov 13 - Sun, Nov 16
Frontier Logo
6:05 pm - 12:44 pmSTL-CLT
17h 39m1 stop
Frontier Logo
5:34 pm - 9:07 amCLT-STL
16h 33m1 stop
$181Frontier
Find Deal
Fri, Oct 10 - Sun, Oct 12
American Airlines Logo
8:30 am - 11:25 amSTL-CLT
1h 55mnonstop
American Airlines Logo
5:23 pm - 6:25 pmCLT-STL
2h 02mnonstop
$217American Airlines
Find Deal
Wed, Oct 22 - Wed, Nov 12
Spirit Airlines Logo
12:20 pm - 12:59 amSTL-CLT
11h 39m1 stop
Spirit Airlines Logo
5:06 pm - 11:01 amCLT-STL
18h 55m1 stop
$219Spirit Airlines
Find Deal
Thu, Dec 11 - Wed, Dec 17
Southwest Logo
6:40 pm - 9:30 pmSTL-CLT
1h 50mnonstop
Southwest Logo
6:20 pm - 10:20 pmCLT-STL
5h 00m1 stop
$227Southwest
Find Deal
Wed, Oct 22 - Wed, Nov 12
Southwest Logo
2:55 pm - 5:40 pmSTL-CLT
1h 45mnonstop
Southwest Logo
6:25 pm - 7:35 pmCLT-STL
2h 10mnonstop
$231Southwest
Find Deal
Thu, Dec 11 - Thu, Dec 18
Delta Logo
10:00 am - 4:03 pmSTL-CLT
5h 03m1 stop
Delta Logo
5:30 am - 10:50 amCLT-STL
6h 20m1 stop
$237Delta
Find Deal
Mon, Mar 2 - Wed, Mar 4
American Airlines Logo
6:00 am - 11:22 amSTL-CLT
4h 22m1 stop
American Airlines Logo
9:58 pm - 11:07 pmCLT-STL
2h 09mnonstop
$240American Airlines
Find Deal
Wed, Nov 5 - Wed, Nov 12
Delta Logo
6:01 am - 12:12 pmSTL-CAE
5h 11m1 stop
Delta Logo
5:45 am - 10:26 amCAE-STL
5h 41m1 stop
$259Delta
Find Deal
Sat, Oct 4 - Wed, Oct 8
Spirit Airlines Logo
7:15 pm - 8:04 pmSTL-MYR
23h 49m1 stop
Spirit Airlines Logo
10:26 am - 6:10 pmMYR-STL
8h 44m1 stop
$288Spirit Airlines
Find Deal
Sat, Oct 18 - Sat, Oct 25

Frontier flights from St. Louis to South Carolina

Our best Frontier deals on St. Louis to South Carolina flight tickets
Frontier
Nov 13
STL6:22 pmLambert-St Louis
15h 20m
1 stop
CLT10:42 amCharlotte Douglas
Nov 16
CLT9:20 pmCharlotte Douglas
13h 20m
1 stop
STL9:40 amLambert-St Louis
$179
Find similar
Frontier
Oct 10
STL6:05 pmLambert-St Louis
17h 39m
1 stop
CLT12:44 pmCharlotte Douglas
Oct 12
CLT5:34 pmCharlotte Douglas
16h 33m
1 stop
STL9:07 amLambert-St Louis
$181
Find similar
Frontier
Oct 17
STL6:05 pmLambert-St Louis
17h 39m
1 stop
CLT12:44 pmCharlotte Douglas
Oct 20
CLT5:34 pmCharlotte Douglas
16h 33m
1 stop
STL9:07 amLambert-St Louis
$189
Find similar

American Airlines flights from St. Louis to South Carolina

Our best American Airlines deals on St. Louis to South Carolina flight tickets
American Airlines
Oct 22
STL8:30 amLambert-St Louis
1h 55m
CLT11:25 amCharlotte Douglas
Nov 12
CLT5:23 pmCharlotte Douglas
2h 02m
STL6:25 pmLambert-St Louis
$217
Find similar
American Airlines
Nov 5
STL6:00 amLambert-St Louis
4h 22m
1 stop
CLT11:22 amCharlotte Douglas
Nov 12
CLT9:58 pmCharlotte Douglas
2h 09m
STL11:07 pmLambert-St Louis
$240
Find similar
American Airlines
Oct 15
STL6:00 amLambert-St Louis
5h 35m
1 stop
CLT12:35 pmCharlotte Douglas
Oct 22
CLT10:00 pmCharlotte Douglas
2h 05m
STL11:05 pmLambert-St Louis
$241
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 22, 2025.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 11/13

6:22 pm-10:42 am

1 stop15h 20m

Charlotte Douglas

Sun 11/16

9:20 pm-9:40 am

1 stop13h 20m

$179

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 10/10

6:05 pm-12:44 pm

1 stop17h 39m

Charlotte Douglas

Sun 10/12

5:34 pm-9:07 am

1 stop16h 33m

$181

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 10/22

8:30 am-11:25 am

Nonstop1h 55m

Charlotte Douglas

Wed 11/12

5:23 pm-6:25 pm

Nonstop2h 02m

$217

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 12/11

12:20 pm-12:59 am

1 stop11h 39m

Charlotte Douglas

Wed 12/17

5:06 pm-11:01 am

1 stop18h 55m

$219

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 10/22

6:40 pm-9:30 pm

Nonstop1h 50m

Charlotte Douglas

Wed 11/12

6:20 pm-10:20 pm

1 stop5h 00m

$227

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 12/11

2:55 pm-5:40 pm

Nonstop1h 45m

Charlotte Douglas

Thu 12/18

6:25 pm-7:35 pm

Nonstop2h 10m

$231

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Mon 3/2

10:00 am-4:03 pm

1 stop5h 03m

Charlotte Douglas

Wed 3/4

5:30 am-10:50 am

1 stop6h 20m

$237

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 11/5

6:00 am-11:22 am

1 stop4h 22m

Charlotte Douglas

Wed 11/12

9:58 pm-11:07 pm

Nonstop2h 09m

$240

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Sat 10/4

6:01 am-12:12 pm

1 stop5h 11m

Columbia Metropolitan

Wed 10/8

5:45 am-10:26 am

1 stop5h 41m

$259

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Sat 10/18

7:15 pm-8:04 pm

1 stop23h 49m

Myrtle Beach Intl

Sat 10/25

10:26 am-6:10 pm

1 stop8h 44m

$288

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from St. Louis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from St. Louis is in August. Flight prices, which tend to average around $320, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from St. Louis during October instead. Flights to South Carolina in October, while not as cheap as those in August, still average around $372.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $544.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest St. Louis to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $387. Try not to purchase tickets in the afternoon because they tend to be around $456. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to South Carolina flight route?

Fly from Lambert-St Louis to Charleston for the best Lambert-St Louis - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $392 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from St. Louis for as low as $328 on momondo.

What cabin class options are available on Lambert-St Louis to South Carolina flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to South Carolina flights?

You could potentially save up to 16% on your flight if you consider stops on a St. Louis to South Carolina flight.

Cheap St. Louis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to South Carolina

Best Price Found

$512

Fastest flight time

1h 45m

Direct flights

Every day

Airports in South Carolina

3 airports
The best flight deal from St. Louis to South Carolina found on momondo in the last 72 hours is $512
The fastest flight from St. Louis to South Carolina takes 1h 45m
Direct flights go from St. Louis to South Carolina every day.
There are 3 airports near South Carolina: Myrtle Beach Intl (MYR), Charlotte Douglas (CLT), Charleston (CHS)
Search flight deals

  • When did momondo last update prices for flights from Lambert-St Louis Airport to South Carolina?

    Prices for flights from Lambert-St Louis Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to South Carolina?

  • How old do you have to be to fly from Lambert-St Louis Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to South Carolina?

Best airlines flying from St. Louis to South Carolina

Compare and see reviews for airlines that fly from St. Louis to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $84Free CancellationRating
6.3
8,031 reviews
Search Spirit Airlines flights
DeltaPriceFrom $150Free CancellationRating
7.9
7,971 reviews
Search Delta flights
American AirlinesPriceFrom $230Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $283Free CancellationRating
8.0
4,244 reviews
Search Southwest flights
United AirlinesPriceFrom $389Free CancellationRating
7.4
8,922 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to South Carolina for you.

Can I find flights from St. Louis to South Carolina with flexible booking policies on momondo?

Flights from St. Louis to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to South Carolina?

Once you have performed a search for St. Louis to South Carolina flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of St. Louis to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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