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Cheap flights from St. Louis to South Carolina from $67

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to South Carolina departing on 1/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:11 pm - 4:54 pm
STL
-
CLT
22h 43m1 stop
Multiple Airlines Logo
11:12 am - 10:34 pm
CLT
-
STL
12h 22m1 stop
$142Multiple Airlines
Mon, Jan 12 - Fri, Jan 16
Frontier Logo
3:43 pm - 5:58 pm
STL
-
CLT
25h 15m1 stop
Frontier Logo
9:56 pm - 11:33 pm
CLT
-
STL
26h 37m1 stop
$147Frontier
Sat, Jan 17 - Mon, Jan 26
Delta Logo
10:13 am - 2:21 pm
STL
-
CAE
3h 08m1 stop
Delta Logo
7:00 am - 12:34 pm
CAE
-
STL
6h 34m1 stop
$211Delta
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
6:00 am - 1:41 pm
STL
-
CAE
6h 41m2 stops
American Airlines Logo
6:28 pm - 11:02 pm
CAE
-
STL
5h 34m1 stop
$216American Airlines
Wed, Feb 18 - Sat, Feb 21
American Airlines Logo
6:52 am - 1:34 pm
STL
-
AGS
5h 42m1 stop
American Airlines Logo
7:09 pm - 11:12 pm
AGS
-
STL
5h 03m1 stop
$226American Airlines
Thu, Jan 15 - Wed, Jan 21
Delta Logo
6:00 am - 11:29 am
STL
-
SAV
4h 29m1 stop
Delta Logo
5:30 am - 8:53 am
SAV
-
STL
4h 23m1 stop
$237Delta
Wed, Jan 21 - Sun, Jan 25
United Airlines Logo
8:30 am - 2:47 pm
STL
-
SAV
5h 17m1 stop
United Airlines Logo
6:40 am - 2:30 pm
SAV
-
STL
8h 50m2 stops
$242United Airlines
Wed, Jan 21 - Sun, Jan 25
United Airlines Logo
6:30 am - 2:47 pm
STL
-
SAV
7h 17m2 stops
United Airlines Logo
6:40 am - 2:30 pm
SAV
-
STL
8h 50m2 stops
$247United Airlines
Wed, Jan 21 - Sun, Jan 25
Southwest Logo
11:35 am - 5:00 pm
STL
-
MYR
4h 25m1 stop
Southwest Logo
3:00 pm - 9:00 pm
MYR
-
STL
7h 00m1 stop
$323Southwest
Wed, Jan 14 - Wed, Jan 21
Southwest Logo
8:20 am - 5:00 pm
STL
-
MYR
7h 40m2 stops
Southwest Logo
11:05 am - 7:05 pm
MYR
-
STL
9h 00m2 stops
$333Southwest
Wed, Jan 14 - Wed, Jan 21

Frontier flights from St. Louis to South Carolina

Our best Frontier deals on St. Louis to South Carolina flight tickets
Frontier
Jan 17
STL3:43 pmLambert-St Louis
25h 15m
1 stop
CLT5:58 pmCharlotte Douglas
Jan 26
CLT9:56 pmCharlotte Douglas
26h 37m
1 stop
STL11:33 pmLambert-St Louis
$147
Find similar
Frontier
Jan 13
STL5:11 pmLambert-St Louis
21h 56m
1 stop
CLT4:07 pmCharlotte Douglas
Jan 20
CLT11:35 amCharlotte Douglas
20h 16m
2 stops
STL6:51 amLambert-St Louis
$162
Find similar
Frontier
Jan 8
STL3:43 pmLambert-St Louis
16h 53m
2 stops
CLT9:36 amCharlotte Douglas
Jan 11
CLT6:00 pmCharlotte Douglas
15h 05m
1 stop
STL8:05 amLambert-St Louis
$175
Find similar

Southwest flights from St. Louis to South Carolina

Our best Southwest deals on St. Louis to South Carolina flight tickets
Southwest
Jan 17
STL1:45 pmLambert-St Louis
4h 30m
1 stop
CLT7:15 pmCharlotte Douglas
Jan 18
CLT8:25 amCharlotte Douglas
2h 10m
STL9:35 amLambert-St Louis
$227
Find similar
Southwest
Feb 5
STL2:55 pmLambert-St Louis
1h 45m
CLT5:40 pmCharlotte Douglas
Feb 8
CLT8:25 amCharlotte Douglas
2h 10m
STL9:35 amLambert-St Louis
$258
Find similar
Southwest
Feb 5
STL1:40 pmLambert-St Louis
5h 45m
1 stop
CLT8:25 pmCharlotte Douglas
Feb 8
CLT8:25 amCharlotte Douglas
2h 10m
STL9:35 amLambert-St Louis
$268
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Mon 1/12

5:11 pm-4:54 pm

1 stop22h 43m

Charlotte Douglas

Fri 1/16

11:12 am-10:34 pm

1 stop12h 22m

$142

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 1/17

3:43 pm-5:58 pm

1 stop25h 15m

Charlotte Douglas

Mon 1/26

9:56 pm-11:33 pm

1 stop26h 37m

$147

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 2/18

10:13 am-2:21 pm

1 stop3h 08m

Columbia Metropolitan

Sat 2/21

7:00 am-12:34 pm

1 stop6h 34m

$211

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 2/18

6:00 am-1:41 pm

2 stops6h 41m

Columbia Metropolitan

Sat 2/21

6:28 pm-11:02 pm

1 stop5h 34m

$216

St. LouisAugusta

STL - AGS

STLAGS

Lambert-St Louis

Thu 1/15

6:52 am-1:34 pm

1 stop5h 42m

Augusta Bush Field

Wed 1/21

7:09 pm-11:12 pm

1 stop5h 03m

$226

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Wed 1/21

6:00 am-11:29 am

1 stop4h 29m

Savannah/Hilton Head

Sun 1/25

5:30 am-8:53 am

1 stop4h 23m

$237

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Wed 1/21

8:30 am-2:47 pm

1 stop5h 17m

Savannah/Hilton Head

Sun 1/25

6:40 am-2:30 pm

2 stops8h 50m

$242

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Wed 1/21

6:30 am-2:47 pm

2 stops7h 17m

Savannah/Hilton Head

Sun 1/25

6:40 am-2:30 pm

2 stops8h 50m

$247

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Wed 1/14

11:35 am-5:00 pm

1 stop4h 25m

Myrtle Beach Intl

Wed 1/21

3:00 pm-9:00 pm

1 stop7h 00m

$323

St. LouisMyrtle Beach

STL - MYR

STLMYR

Lambert-St Louis

Wed 1/14

8:20 am-5:00 pm

2 stops7h 40m

Myrtle Beach Intl

Wed 1/21

11:05 am-7:05 pm

2 stops9h 00m

$333

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from St. Louis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from St. Louis is in August. Flight prices, which tend to average around $319, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from St. Louis during November instead. Flights to South Carolina in November, while not as cheap as those in August, still average around $328.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $488.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest St. Louis to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $387. Try not to purchase tickets in the afternoon because they tend to be around $456. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to South Carolina flight route?

Fly from Lambert-St Louis to Myrtle Beach Intl for the best Lambert-St Louis - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from St. Louis for as low as $336 on momondo.

What cabin class options are available on Lambert-St Louis to South Carolina flights?

There is only 1 cabin class available to choose from on Lambert-St Louis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to South Carolina flights?

No. A direct flight is the cheapest option for a flight between St. Louis to South Carolina.

Cheap St. Louis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to South Carolina

Fastest flight time

1h 45m

Direct flights

Every day

Airports in South Carolina

57 airports
The fastest flight from St. Louis to South Carolina takes 1h 45m
Direct flights go from St. Louis to South Carolina every day.
There are 57 airports in South Carolina. From St. Louis there are direct flights to Myrtle Beach Intl (MYR), Savannah/Hilton Head (SAV), Charlotte Douglas (CLT), Charleston (CHS).
Search flight deals

  • When did momondo last update prices for flights from Lambert-St Louis Airport to South Carolina?

    Prices for flights from Lambert-St Louis Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to South Carolina?

  • How old do you have to be to fly from Lambert-St Louis Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from St. Louis to South Carolina?

Best airlines flying from St. Louis to South Carolina

Compare and see reviews for airlines that fly from St. Louis to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $84Free CancellationRating
6.3
8,190 reviews
Search Spirit Airlines flights
DeltaPriceFrom $146Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $226Free CancellationRating
7.2
11,055 reviews
Search American Airlines flights
SouthwestPriceFrom $271Free CancellationRating
7.9
4,250 reviews
Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to South Carolina for you.

Can I find flights from St. Louis to South Carolina with flexible booking policies on momondo?

Flights from St. Louis to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to South Carolina?

Once you have performed a search for St. Louis to South Carolina flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of St. Louis to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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