What is the cheapest airline that flies from Lambert-St Louis to South Carolina?

American Airlines, United Airlines, and Southwest are the most popular carriers operating from Lambert-St Louis to South Carolina

What airlines fly to South Carolina?

American Airlines, Southwest and Delta are the top three most popular airlines that fly to South Carolina from St. Louis according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many flights depart from St. Louis to South Carolina on average per week?

As of November 2026, 6 flights take off from St. Louis and land in South Carolina each week. The most common flight departure day for this route is Mon, with 17% of weekly flights taking off on this day.

When did momondo last update prices for flights from Lambert-St Louis Airport to South Carolina?

Prices for flights from Lambert-St Louis Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Lambert-St Louis Airport to South Carolina?

There are 4 operators available for flights from Lambert-St Louis Airport to South Carolina as of November 2026.

How old do you have to be to fly from Lambert-St Louis Airport to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$111 Cheap Flights from St. Louis to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from St. Louis to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:05 pm - 11:59 pmSTL Lambert-St Louis-CHS Charleston

5h 54m1 stop Newark

6:00 am - 12:24 pmCHS Charleston-STL Lambert-St Louis

7h 24m1 stop Chicago O'Hare Intl

$222United Airlines

Fri, Dec 4 - Sat, Dec 5

6:48 am - 1:54 pmSTL Lambert-St Louis-CHS Charleston

6h 06m1 stop Washington, D.C. Reagan-National

4:18 pm - 10:06 pmCHS Charleston-STL Lambert-St Louis

6h 48m1 stop Washington, D.C. Reagan-National

$227American Airlines

Thu, Jan 7 - Mon, Jan 11

6:00 am - 11:50 amSTL Lambert-St Louis-CHS Charleston

4h 50m1 stop Atlanta Hartsfield-Jackson

2:04 pm - 4:54 pmCHS Charleston-STL Lambert-St Louis

3h 50m1 stop Atlanta Hartsfield-Jackson

$227Delta

Wed, Dec 2 - Tue, Dec 15

6:00 am - 12:59 pmSTL Lambert-St Louis-CHS Charleston

5h 59m1 stop Atlanta Hartsfield-Jackson

5:34 pm - 9:38 pmCHS Charleston-STL Lambert-St Louis

5h 04m1 stop Atlanta Hartsfield-Jackson

$227Delta

Wed, Dec 2 - Wed, Dec 16

7:27 am - 3:26 pmSTL Lambert-St Louis-CHS Charleston

6h 59m1 stop Chicago O'Hare Intl

6:00 am - 10:08 amCHS Charleston-STL Lambert-St Louis

5h 08m1 stop Washington, D.C. Reagan-National

$227American Airlines

Wed, Dec 2 - Mon, Dec 7

6:20 pm - 8:38 amSTL Lambert-St Louis-CHS Charleston

13h 18m1 stop Orlando

8:58 pm - 11:17 amCHS Charleston-STL Lambert-St Louis

39h 19m2 stops Tampa Atlanta Hartsfield-Jackson

$231Multiple Airlines

Mon, Dec 7 - Mon, Dec 14

10:55 am - 4:30 pmSTL Lambert-St Louis-CHS Charleston

4h 35m1 stop Chicago Midway

1:30 pm - 7:25 pmCHS Charleston-STL Lambert-St Louis

6h 55m2 stops Baltimore/Washington Pittsburgh

$232Southwest

Tue, Dec 1 - Mon, Dec 14

8:05 am - 1:46 pmSTL Lambert-St Louis-CHS Charleston

4h 41m1 stop Chicago O'Hare Intl

3:23 pm - 11:20 pmCHS Charleston-STL Lambert-St Louis

8h 57m2 stops Newark Chicago O'Hare Intl

$232United Airlines

Thu, Jan 7 - Mon, Jan 11

10:30 am - 5:25 pmSTL Lambert-St Louis-CHS Charleston

5h 55m1 stop Nashville Intl

6:40 am - 4:15 pmCHS Charleston-STL Lambert-St Louis

10h 35m2 stops Nashville Intl Tampa

$286Southwest

Fri, Dec 4 - Sat, Dec 5

6:13 pm - 8:45 amSTL Lambert-St Louis-MYR Myrtle Beach Intl

13h 32m1 stop Orlando

2:46 pm - 12:12 amMYR Myrtle Beach Intl-STL Lambert-St Louis

10h 26m1 stop Orlando

$391Multiple Airlines

Thu, Dec 3 - Thu, Dec 10

Cheap last minute flights

Enter your travel dates to find the best prices.

5:00 am - 2:39 pmSTL Lambert-St Louis-CHS Charleston

8h 39m1 stop Dallas/Fort Worth

12:17 pm - 4:44 pmCHS Charleston-STL Lambert-St Louis

5h 27m1 stop Chicago O'Hare Intl

$409American Airlines

Wed, Nov 11 - Wed, Nov 25

10:37 am - 4:58 pmSTL Lambert-St Louis-CHS Charleston

5h 21m1 stop Charlotte Douglas

6:00 am - 10:03 amCHS Charleston-STL Lambert-St Louis

5h 03m1 stop Washington, D.C. Reagan-National

$409American Airlines

Tue, Nov 10 - Tue, Nov 17

10:53 am - 5:00 pmSTL Lambert-St Louis-CAE Columbia Metropolitan

5h 07m1 stop Chicago O'Hare Intl

10:37 am - 3:43 pmCAE Columbia Metropolitan-STL Lambert-St Louis

6h 06m1 stop Chicago O'Hare Intl

$428United Airlines

Thu, Nov 12 - Tue, Nov 17

6:00 am - 2:17 pmSTL Lambert-St Louis-CAE Columbia Metropolitan

7h 17m2 stops Newark Washington, D.C. Dulles Intl

5:37 pm - 9:40 pmCAE Columbia Metropolitan-STL Lambert-St Louis

5h 03m1 stop Chicago O'Hare Intl

$433United Airlines

Thu, Nov 12 - Tue, Nov 17

6:00 am - 1:14 pmSTL Lambert-St Louis-CAE Columbia Metropolitan

6h 14m1 stop Atlanta Hartsfield-Jackson

5:35 am - 9:03 amCAE Columbia Metropolitan-STL Lambert-St Louis

4h 28m1 stop Atlanta Hartsfield-Jackson

$456Delta

Thu, Nov 12 - Sat, Nov 28

12:14 pm - 8:48 amSTL Lambert-St Louis-CHS Charleston

19h 34m2 stops Dallas/Fort Worth Orlando

2:13 pm - 12:25 pmCHS Charleston-STL Lambert-St Louis

23h 12m1 stop Orlando

$457Multiple Airlines

Thu, Nov 12 - Thu, Nov 26

6:00 am - 1:14 pmSTL Lambert-St Louis-CAE Columbia Metropolitan

6h 14m1 stop Atlanta Hartsfield-Jackson

5:35 am - 9:03 amCAE Columbia Metropolitan-STL Lambert-St Louis

4h 28m1 stop Atlanta Hartsfield-Jackson

$461Delta

Thu, Nov 12 - Sat, Nov 28

4:26 pm - 8:48 amSTL Lambert-St Louis-CHS Charleston

15h 22m1 stop Orlando

2:13 pm - 11:59 pmCHS Charleston-STL Lambert-St Louis

10h 46m1 stop Orlando

$469Multiple Airlines

Thu, Nov 12 - Thu, Nov 26

5:30 am - 2:10 pmSTL Lambert-St Louis-GSP Greenville

7h 40m2 stops Dallas Love Field Nashville Intl

8:50 pm - 11:55 pmGSP Greenville-STL Lambert-St Louis

4h 05m1 stop Nashville Intl

$683Southwest

Wed, Nov 11 - Fri, Nov 13

4:30 pm - 8:50 pmSTL Lambert-St Louis-GSP Greenville

3h 20m1 stop Nashville Intl

1:00 pm - 7:10 pmGSP Greenville-STL Lambert-St Louis

7h 10m2 stops Baltimore/Washington Milwaukee-Mitchell

$683Southwest

Wed, Nov 11 - Thu, Nov 12

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American Airlines flights from St. Louis to South Carolina

Our best American Airlines deals on St. Louis to South Carolina flight tickets

American Airlines

Jan 22

STL3:45 pmLambert-St Louis

5h 41m

1 stop

CHS10:26 pmCharleston

Jan 24

CHS4:48 pmCharleston

7h 44m

1 stop

STL11:32 pmLambert-St Louis

$314

American Airlines

Jan 13

STL8:13 amLambert-St Louis

6h 40m

1 stop

HHH3:53 pmHilton Head Island

Jan 19

HHH4:25 pmHilton Head Island

6h 24m

1 stop

STL9:49 pmLambert-St Louis

$331

American Airlines

Dec 1

STL9:03 amLambert-St Louis

3h 59m

1 stop

GSP2:02 pmGreenville

Dec 5

GSP6:27 amGreenville

4h 11m

1 stop

STL9:38 amLambert-St Louis

$333

Southwest flights from St. Louis to South Carolina

Our best Southwest deals on St. Louis to South Carolina flight tickets

Southwest

Dec 1

STL10:55 amLambert-St Louis

4h 35m

1 stop

CHS4:30 pmCharleston

Dec 14

CHS1:30 pmCharleston

6h 55m

2 stops

STL7:25 pmLambert-St Louis

$232

Southwest

Dec 22

STL10:10 amLambert-St Louis

10h 50m

2 stops

CHS10:00 pmCharleston

Dec 31

CHS6:35 amCharleston

8h 10m

2 stops

STL1:45 pmLambert-St Louis

$243

Southwest

Feb 3

STL11:30 amLambert-St Louis

7h 10m

2 stops

GSP7:40 pmGreenville

Feb 9

GSP7:15 amGreenville

8h 35m

2 stops

STL2:50 pmLambert-St Louis

$299

momondo Fare Finder

Use the filters below to find and compare flights from St. Louis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Fri 12/4

5:05 pm-11:59 pm

1 stop5h 54m

Charleston

Sat 12/5

6:00 am-12:24 pm

1 stop7h 24m

$222

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Thu 1/7

6:48 am-1:54 pm

1 stop6h 06m

Charleston

Mon 1/11

4:18 pm-10:06 pm

1 stop6h 48m

$227

Quickest round-trip

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Wed 12/2

6:00 am-11:50 am

1 stop4h 50m

Charleston

Tue 12/15

2:04 pm-4:54 pm

1 stop3h 50m

$227

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Wed 12/2

6:00 am-12:59 pm

1 stop5h 59m

Charleston

Wed 12/16

5:34 pm-9:38 pm

1 stop5h 04m

$227

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Wed 12/2

7:27 am-3:26 pm

1 stop6h 59m

Charleston

Mon 12/7

6:00 am-10:08 am

1 stop5h 08m

$227

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Mon 12/7

6:20 pm-8:38 am

1 stop13h 18m

Charleston

Mon 12/14

8:58 pm-11:17 am

2 stops39h 19m

$231

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Tue 12/1

10:55 am-4:30 pm

1 stop4h 35m

Charleston

Mon 12/14

1:30 pm-7:25 pm

2 stops6h 55m

$232

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Thu 1/7

8:05 am-1:46 pm

1 stop4h 41m

Charleston

Mon 1/11

3:23 pm-11:20 pm

2 stops8h 57m

$232

St. LouisCharleston

STL Lambert-St Louis - CHS Charleston

STLCHS

Lambert-St Louis

Fri 12/4

10:30 am-5:25 pm

1 stop5h 55m

Charleston

Sat 12/5

6:40 am-4:15 pm

2 stops10h 35m

$286

St. LouisMyrtle Beach

STL Lambert-St Louis - MYR Myrtle Beach Intl

STLMYR

Lambert-St Louis

Thu 12/3

6:13 pm-8:45 am

1 stop13h 32m

Myrtle Beach Intl

Thu 12/10

2:46 pm-12:12 am

1 stop10h 26m

$391

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from St. Louis to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from St. Louis is in February. Flight prices, which tend to average around $338, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to South Carolina from St. Louis during January instead. Flights to South Carolina in January, while not as cheap as those in February, still average around $349.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $308. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $559.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest St. Louis to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $412. Try not to purchase tickets at noon because they tend to be around $456. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Lambert-St Louis to South Carolina flight route?

Fly from Lambert-St Louis to Charleston for the best Lambert-St Louis - South Carolina flight prices

How far in advance should I book a flight from St. Louis to South Carolina?

You are more likely to see cheaper flights to South Carolina from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $395 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from St. Louis for as low as $270 on momondo.

What cabin class options are available on St. Louis to South Carolina flights?

There is only 1 cabin class available to choose from on St. Louis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on St. Louis to South Carolina flights?

No. A direct flight is the cheapest option for a flight between St. Louis to South Carolina.

Cheap St. Louis to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to South Carolina

Best Price Found	$111
Fastest flight time	1h 40m
Direct flights	Sat
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from St. Louis in the past 72 hours is $111. The best round-trip flight deal from St. Louis to South Carolina found on momondo in the last 72 hours is $222.

The fastest flight from St. Louis to South Carolina takes 1h 40m

Direct flights go from St. Louis to South Carolina on Saturday. There are no airlines offering direct flights.

There are 57 airports in South Carolina. From St. Louis there are direct flights to Charleston (CHS).

Search flight deals

Frequently asked questions about flying from St. Louis to South Carolina

When did momondo last update prices for flights from Lambert-St Louis Airport to South Carolina?
Prices for flights from Lambert-St Louis Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Lambert-St Louis Airport to South Carolina?
There are 4 operators available for flights from Lambert-St Louis Airport to South Carolina as of November 2026.
How old do you have to be to fly from Lambert-St Louis Airport to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Lambert-St Louis Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents you'll need for your trip to South Carolina may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South Carolina. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from St. Louis to South Carolina?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from St. Louis to South Carolina is Boeing 737 MAX 8 (52.38% of total bookings). The next most popular plane models are Boeing 737 (14.29%), Boeing 737-700 Passenger/BBJ1 (winglets) (14.29%), and Boeing 737-800 Passenger/BBJ2 (winglets) (9.52%).

Best airlines flying from St. Louis to South Carolina

Compare and see reviews for airlines that fly from St. Louis to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $195	Free Cancellation	Rating 7.0 12,228 reviews	Search American Airlines flights
Delta	PriceFrom $196	Free Cancellation	Rating 7.8 8,698 reviews	Search Delta flights
United Airlines	PriceFrom $196	Free Cancellation	Rating 7.3 10,469 reviews	Search United Airlines flights
Southwest	PriceFrom $245	Free Cancellation	Rating 8.0 4,215 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from St. Louis to South Carolina for you.

Can I find flights from St. Louis to South Carolina with flexible booking policies on momondo?

Flights from St. Louis to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from St. Louis to South Carolina?

Once you have performed a search for St. Louis to South Carolina flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from St. Louis to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of St. Louis to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.