Cheap flights from St. Louis to South Carolina from $70

The cheapest month to fly to South Carolina from St. Louis is in August. Flight prices, which tend to average around $317, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from St. Louis during November instead. Flights to South Carolina in November, while not as cheap as those in August, still average around $328.

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $305. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $544.

Our data shows that the cheapest St. Louis to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $364. Try not to purchase tickets at noon because they tend to be around $462. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Lambert-St Louis to Charleston for the best Lambert-St Louis - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $380 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from St. Louis for as low as $294 on momondo.

There is only 1 cabin class available to choose from on Lambert-St Louis to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Southwest, United Airlines, and Delta are the most popular carriers operating from Lambert-St Louis to South Carolina

American Airlines, Delta and Southwest are the top three most popular airlines that fly to South Carolina from St. Louis according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

The number of flights available between St. Louis and South Carolina is 5 per day as of March 2026. The most frequent departure time is 3:00PM, with 100% of daily flights leaving in the afternoon.

As of March 2026, 37 flights take off from St. Louis and land in South Carolina each week. The most common flight departure day for this route is Mon, with 19% of weekly flights taking off on this day.