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Cheap flights from St. Louis to Roanoke from $263

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Roanoke departing on 4/29. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:50 pm - 12:25 am
STL
-
ROA
4h 35m
1 stop
Delta Logo
7:50 pm - 11:36 pm
ROA
-
STL
4h 46m
1 stop
$329Delta
Fri, Apr 17 - Mon, Apr 20
American Airlines Logo
8:54 am - 5:33 pm
STL
-
ROA
7h 39m
2 stops
American Airlines Logo
7:28 am - 11:47 am
ROA
-
STL
5h 19m
1 stop
$334American Airlines
Tue, Apr 14 - Sat, Apr 18
United Airlines Logo
8:21 am - 1:29 pm
STL
-
ROA
4h 08m
1 stop
United Airlines Logo
5:45 pm - 9:13 pm
ROA
-
STL
4h 28m
1 stop
$339United Airlines
Fri, Apr 3 - Mon, Apr 6
Delta Logo
4:21 pm - 12:04 am
STL
-
ROA
6h 43m
1 stop
Delta Logo
6:00 am - 11:09 am
ROA
-
STL
6h 09m
1 stop
$369Delta
Fri, Apr 3 - Sun, Apr 5
United Airlines Logo
9:16 am - 5:06 pm
STL
-
ROA
6h 50m
1 stop
United Airlines Logo
5:47 pm - 11:00 pm
ROA
-
STL
6h 13m
1 stop
$409United Airlines
Sat, Aug 22 - Wed, Aug 26
Delta Logo
7:01 pm - 12:34 am
STL
-
ROA
4h 33m
1 stop
Delta Logo
7:57 pm - 11:56 pm
ROA
-
STL
4h 59m
1 stop
$418Delta
Fri, Jun 5 - Sun, Jun 7
United Airlines Logo
7:45 am - 1:29 pm
STL
-
ROA
4h 44m
1 stop
United Airlines Logo
6:45 am - 10:45 am
ROA
-
STL
5h 00m
1 stop
$428United Airlines
Fri, Apr 10 - Sun, Apr 12
United Airlines Logo
6:00 am - 1:33 pm
STL
-
ROA
6h 33m
1 stop
United Airlines Logo
6:40 am - 12:11 pm
ROA
-
STL
6h 31m
1 stop
$448United Airlines
Fri, Jun 5 - Sun, Jun 7
United Airlines Logo
5:41 pm - 12:24 am
STL
-
ROA
5h 43m
1 stop
United Airlines Logo
6:40 am - 12:11 pm
ROA
-
STL
6h 31m
1 stop
$458United Airlines
Fri, Jun 5 - Sun, Jun 7
Delta Logo
7:01 pm - 12:34 am
STL
-
ROA
4h 33m
1 stop
Delta Logo
7:50 pm - 11:38 pm
ROA
-
STL
4h 48m
1 stop
$467Delta
Fri, Jun 5 - Sun, Jun 7

Delta flights from St. Louis to Roanoke

Our best Delta deals on St. Louis to Roanoke flight tickets
Delta
Apr 17
STL6:50 pmLambert-St Louis
4h 35m
1 stop
ROA12:25 amRoanoke
Apr 20
ROA7:50 pmRoanoke
4h 46m
1 stop
STL11:36 pmLambert-St Louis
$329
Delta
Apr 3
STL4:21 pmLambert-St Louis
6h 43m
1 stop
ROA12:04 amRoanoke
Apr 5
ROA6:00 amRoanoke
6h 09m
1 stop
STL11:09 amLambert-St Louis
$369
Delta
Jun 5
STL7:01 pmLambert-St Louis
4h 33m
1 stop
ROA12:34 amRoanoke
Jun 7
ROA7:57 pmRoanoke
4h 59m
1 stop
STL11:56 pmLambert-St Louis
$418

American Airlines flights from St. Louis to Roanoke

Our best American Airlines deals on St. Louis to Roanoke flight tickets
American Airlines
Apr 14
STL8:54 amLambert-St Louis
7h 39m
2 stops
ROA5:33 pmRoanoke
Apr 18
ROA7:28 amRoanoke
5h 19m
1 stop
STL11:47 amLambert-St Louis
$334
American Airlines
Apr 3
STL3:49 pmLambert-St Louis
6h 56m
2 stops
ROA11:45 pmRoanoke
Apr 6
ROA6:04 pmRoanoke
5h 58m
1 stop
STL11:02 pmLambert-St Louis
$719
American Airlines
Apr 3
STL9:36 amLambert-St Louis
7h 03m
2 stops
ROA5:39 pmRoanoke
Apr 5
ROA7:50 amRoanoke
6h 53m
1 stop
STL1:43 pmLambert-St Louis
$809

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from St. Louis to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 4/17

6:50 pm-12:25 am

1 stop4h 35m

Roanoke

Mon 4/20

7:50 pm-11:36 pm

1 stop4h 46m

$329

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Tue 4/14

8:54 am-5:33 pm

2 stops7h 39m

Roanoke

Sat 4/18

7:28 am-11:47 am

1 stop5h 19m

$334
Quickest round-trip

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 4/3

8:21 am-1:29 pm

1 stop4h 08m

Roanoke

Mon 4/6

5:45 pm-9:13 pm

1 stop4h 28m

$339

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 4/3

4:21 pm-12:04 am

1 stop6h 43m

Roanoke

Sun 4/5

6:00 am-11:09 am

1 stop6h 09m

$369

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Sat 8/22

9:16 am-5:06 pm

1 stop6h 50m

Roanoke

Wed 8/26

5:47 pm-11:00 pm

1 stop6h 13m

$409

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 6/5

7:01 pm-12:34 am

1 stop4h 33m

Roanoke

Sun 6/7

7:57 pm-11:56 pm

1 stop4h 59m

$418

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 4/10

7:45 am-1:29 pm

1 stop4h 44m

Roanoke

Sun 4/12

6:45 am-10:45 am

1 stop5h 00m

$428

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 6/5

6:00 am-1:33 pm

1 stop6h 33m

Roanoke

Sun 6/7

6:40 am-12:11 pm

1 stop6h 31m

$448

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 6/5

5:41 pm-12:24 am

1 stop5h 43m

Roanoke

Sun 6/7

6:40 am-12:11 pm

1 stop6h 31m

$458

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 6/5

7:01 pm-12:34 am

1 stop4h 33m

Roanoke

Sun 6/7

7:50 pm-11:38 pm

1 stop4h 48m

$467

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Roanoke from

How to get the cheapest flight ticket from St. Louis to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Lambert-St Louis to Roanoke?

United Airlines is the most popular carrier operating from Lambert-St Louis to Roanoke

What airlines fly to Roanoke?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Roanoke from St. Louis according to our data. American Airlines is the first choice among our users, with 51% of people opting to fly with this airline when traveling to Roanoke. Keep in mind that there are 3 different airlines that fly to Roanoke on a routine basis, so you have a few additional options to choose from.

When to book flights from St. Louis to Roanoke

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Roanoke according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Roanoke (STL to ROA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Roanoke

Fastest flight time

4h 33m

Direct flights

None
The fastest flight from St. Louis to Roanoke takes 4h 33m
There are no direct flights from St. Louis to Roanoke. There are no popular flight routes from St. Louis to Roanoke.
Search flight deals

  • How far is Lambert-St Louis to Roanoke by plane?

    The straight-line distance from Lambert-St Louis to Roanoke is 565.9 mi. Typically, this will take 4h 33m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Roanoke Airport?

    Prices for flights from Lambert-St Louis Airport to Roanoke Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Roanoke Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Roanoke Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The necessary travel and health documents for your Roanoke Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Roanoke?

Best airlines flying from St. Louis to Roanoke

Compare and see reviews for airlines that fly from St. Louis to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $196Free CancellationRating
7.9
8,319 reviews
Search Delta flights
American AirlinesPriceFrom $224Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
9,460 reviews
Search United Airlines flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Salem
Christiansburg
Radford
Rocky Mount

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Roanoke?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Roanoke. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Roanoke with flexible booking policies on momondo?

momondo does allow users to show only those flights to Roanoke from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Roanoke?

Once all potential St. Louis to Roanoke flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from St. Louis to Roanoke right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of St. Louis to Roanoke flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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