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Cheap flights from St. Louis to Roanoke from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Roanoke departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from St. Louis to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:33 am - 4:08 pm
STL
-
ROA
7h 35m1 stop
American Airlines Logo
5:05 am - 8:05 am
ROA
-
STL
4h 00m1 stop
$345American Airlines
Thu, Apr 23 - Sun, Apr 26
American Airlines Logo
8:13 am - 1:31 pm
STL
-
ROA
4h 18m1 stop
American Airlines Logo
5:14 pm - 11:26 pm
ROA
-
STL
7h 12m1 stop
$352American Airlines
Thu, Jan 8 - Sat, Jan 10
American Airlines Logo
6:31 am - 11:51 am
STL
-
ROA
4h 20m1 stop
American Airlines Logo
5:04 am - 7:59 am
ROA
-
STL
3h 55m1 stop
$400American Airlines
Thu, Jun 4 - Sun, Jun 7
American Airlines Logo
6:31 am - 11:51 am
STL
-
ROA
4h 20m1 stop
American Airlines Logo
8:28 pm - 11:26 pm
ROA
-
STL
3h 58m1 stop
$441American Airlines
Fri, Jun 5 - Sun, Jun 7
United Airlines Logo
8:30 am - 2:09 pm
STL
-
ROA
4h 39m1 stop
United Airlines Logo
12:40 pm - 4:03 pm
ROA
-
STL
4h 23m1 stop
$449United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
8:05 am - 2:46 pm
STL
-
ROA
5h 41m1 stop
United Airlines Logo
6:45 am - 8:58 pm
ROA
-
STL
15h 13m2 stops
$512United Airlines
Thu, Jan 8 - Sat, Jan 10
United Airlines Logo
4:49 pm - 12:05 pm
STL
-
ROA
18h 16m1 stop
United Airlines Logo
2:55 pm - 7:27 pm
ROA
-
STL
5h 32m1 stop
$519United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
8:30 am - 2:09 pm
STL
-
ROA
4h 39m1 stop
United Airlines Logo
10:15 am - 9:13 pm
ROA
-
STL
11h 58m2 stops
$525United Airlines
Sat, Jan 17 - Wed, Jan 21
United Airlines Logo
4:15 pm - 2:46 pm
STL
-
ROA
21h 31m2 stops
United Airlines Logo
3:39 pm - 7:27 pm
ROA
-
STL
4h 48m1 stop
$577United Airlines
Sat, Jan 17 - Wed, Jan 21
American Airlines Logo
6:52 am - 3:05 pm
STL
-
ROA
7h 13m1 stop
American Airlines Logo
8:50 am - 3:04 pm
ROA
-
STL
7h 14m1 stop
$598American Airlines
Sun, Jan 18 - Mon, Jan 19

United Airlines flights from St. Louis to Roanoke

Our best United Airlines deals on St. Louis to Roanoke flight tickets
United Airlines
Jan 17
STL8:30 amLambert-St Louis
4h 39m
1 stop
ROA2:09 pmRoanoke
Jan 21
ROA12:40 pmRoanoke
4h 23m
1 stop
STL4:03 pmLambert-St Louis
$449
Find similar
United Airlines
Jan 8
STL8:05 amLambert-St Louis
5h 41m
1 stop
ROA2:46 pmRoanoke
Jan 10
ROA6:45 amRoanoke
15h 13m
2 stops
STL8:58 pmLambert-St Louis
$512
Find similar
United Airlines
Jan 17
STL4:49 pmLambert-St Louis
18h 16m
1 stop
ROA12:05 pmRoanoke
Jan 21
ROA2:55 pmRoanoke
5h 32m
1 stop
STL7:27 pmLambert-St Louis
$519
Find similar

American Airlines flights from St. Louis to Roanoke

Our best American Airlines deals on St. Louis to Roanoke flight tickets
American Airlines
Apr 23
STL7:33 amLambert-St Louis
7h 35m
1 stop
ROA4:08 pmRoanoke
Apr 26
ROA5:05 amRoanoke
4h 00m
1 stop
STL8:05 amLambert-St Louis
$345
Find similar
American Airlines
Jan 8
STL8:13 amLambert-St Louis
4h 18m
1 stop
ROA1:31 pmRoanoke
Jan 10
ROA5:14 pmRoanoke
7h 12m
1 stop
STL11:26 pmLambert-St Louis
$352
Find similar
American Airlines
Jun 4
STL6:31 amLambert-St Louis
4h 20m
1 stop
ROA11:51 amRoanoke
Jun 7
ROA6:00 amRoanoke
6h 49m
1 stop
STL11:49 amLambert-St Louis
$400
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from St. Louis to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 4/23

7:33 am-4:08 pm

1 stop7h 35m

Roanoke

Sun 4/26

5:05 am-8:05 am

1 stop4h 00m

$345

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 1/8

8:13 am-1:31 pm

1 stop4h 18m

Roanoke

Sat 1/10

5:14 pm-11:26 pm

1 stop7h 12m

$352

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 6/4

6:31 am-11:51 am

1 stop4h 20m

Roanoke

Sun 6/7

5:04 am-7:59 am

1 stop3h 55m

$400

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 6/5

6:31 am-11:51 am

1 stop4h 20m

Roanoke

Sun 6/7

8:28 pm-11:26 pm

1 stop3h 58m

$441

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Sat 1/17

8:30 am-2:09 pm

1 stop4h 39m

Roanoke

Wed 1/21

12:40 pm-4:03 pm

1 stop4h 23m

$449

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 1/8

8:05 am-2:46 pm

1 stop5h 41m

Roanoke

Sat 1/10

6:45 am-8:58 pm

2 stops15h 13m

$512

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Sat 1/17

4:49 pm-12:05 pm

1 stop18h 16m

Roanoke

Wed 1/21

2:55 pm-7:27 pm

1 stop5h 32m

$519

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Sat 1/17

8:30 am-2:09 pm

1 stop4h 39m

Roanoke

Wed 1/21

10:15 am-9:13 pm

2 stops11h 58m

$525

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Sat 1/17

4:15 pm-2:46 pm

2 stops21h 31m

Roanoke

Wed 1/21

3:39 pm-7:27 pm

1 stop4h 48m

$577

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Sun 1/18

6:52 am-3:05 pm

1 stop7h 13m

Roanoke

Mon 1/19

8:50 am-3:04 pm

1 stop7h 14m

$598

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Roanoke from

How to get the cheapest flight ticket from St. Louis to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Roanoke?

The month of January is, on average, the cheapest month to fly to Roanoke from St. Louis, with most prices found around $248. If you aren’t able to travel to Roanoke during the month of January, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $254.

What is the cheapest day to depart on your flight to Roanoke?

Our data shows that Monday is the least expensive day to fly to Roanoke. Tickets to fly out on this day can be as low as $323. Flights from St. Louis to Roanoke on a Saturday will generally be more expensive and average around $362. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Roanoke?

Our most recent data shows that the best time of day to fly to Roanoke is in the evening. Flights from St. Louis to Roanoke during this time can be as low as $330. In contrast, the most expensive time of day to depart to Roanoke is at noon when prices are around $368.

When to book flights from St. Louis to Roanoke

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Roanoke according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Roanoke (STL to ROA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Roanoke

Fastest flight time

4h 35m

Direct flights

None
The fastest flight from St. Louis to Roanoke takes 4h 35m
There are no direct flights from St. Louis to Roanoke. There are no popular flight routes from St. Louis to Roanoke.
Search flight deals

  • How far is Lambert-St Louis to Roanoke by plane?

    The straight-line distance from Lambert-St Louis to Roanoke is 565.9 mi. Typically, this will take 4h 35m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Roanoke Airport?

    Prices for flights from Lambert-St Louis Airport to Roanoke Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Roanoke Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Roanoke Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The necessary travel and health documents for your Roanoke Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Roanoke?

Best airlines flying from St. Louis to Roanoke

Compare and see reviews for airlines that fly from St. Louis to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $224Free CancellationRating
7.2
11,055 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,004 reviews
Search Delta flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
9,092 reviews
Search United Airlines flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Salem
Blacksburg
Christiansburg
Radford
Rocky Mount
Lafayette

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Roanoke?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Roanoke. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Roanoke with flexible booking policies on momondo?

momondo does allow users to show only those flights to Roanoke from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Roanoke?

Once all potential St. Louis to Roanoke flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from St. Louis to Roanoke right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of St. Louis to Roanoke flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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