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Cheap flights from St. Louis to Roanoke from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from St. Louis to Roanoke departing on 3/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from St. Louis to Roanoke

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
2:00 pm - 8:30 pm
STL
-
ROA
5h 30m
1 stop
American Airlines Logo
8:15 am - 12:33 pm
ROA
-
STL
5h 18m
1 stop
$279American Airlines
Thu, Feb 19 - Mon, Feb 23
Delta Logo
6:59 pm - 12:04 am
STL
-
ROA
4h 05m
1 stop
Delta Logo
6:00 am - 11:09 am
ROA
-
STL
6h 09m
1 stop
$303Delta
Wed, Mar 25 - Wed, Apr 1
Delta Logo
5:15 pm - 10:59 pm
STL
-
ROA
4h 44m
1 stop
Delta Logo
6:00 am - 9:05 am
ROA
-
STL
4h 05m
1 stop
$304Delta
Wed, Mar 25 - Mon, Mar 30
Delta Logo
6:56 pm - 12:06 am
STL
-
ROA
4h 10m
1 stop
Delta Logo
6:00 am - 11:09 am
ROA
-
STL
6h 09m
1 stop
$319Delta
Sun, Mar 1 - Sun, Mar 8
American Airlines Logo
2:00 pm - 8:30 pm
STL
-
ROA
5h 30m
1 stop
American Airlines Logo
5:00 am - 8:35 am
ROA
-
STL
4h 35m
1 stop
$339American Airlines
Fri, Apr 3 - Mon, Apr 6
United Airlines Logo
8:30 am - 2:12 pm
STL
-
ROA
4h 42m
1 stop
United Airlines Logo
5:33 pm - 9:05 pm
ROA
-
STL
4h 32m
1 stop
$349United Airlines
Tue, Feb 17 - Sat, Feb 21
United Airlines Logo
8:30 am - 2:12 pm
STL
-
ROA
4h 42m
1 stop
United Airlines Logo
6:40 am - 10:36 am
ROA
-
STL
4h 56m
1 stop
$350United Airlines
Wed, Feb 18 - Sun, Feb 22
Multiple Airlines Logo
4:51 pm - 7:51 pm
STL
-
ROA
26h 00m
1 stop
Multiple Airlines Logo
4:02 pm - 10:32 am
ROA
-
STL
19h 30m
2 stops
$401Multiple Airlines
Thu, Mar 19 - Mon, Mar 23
American Airlines Logo
1:34 pm - 9:25 pm
STL
-
ROA
6h 51m
1 stop
American Airlines Logo
8:15 am - 12:44 pm
ROA
-
STL
5h 29m
1 stop
$418American Airlines
Fri, Mar 6 - Sun, Mar 8
Delta Logo
12:04 pm - 7:11 pm
STL
-
ROA
6h 07m
1 stop
Delta Logo
7:51 pm - 11:58 pm
ROA
-
STL
5h 07m
1 stop
$419Delta
Thu, Mar 19 - Mon, Mar 23

American Airlines flights from St. Louis to Roanoke

Our best American Airlines deals on St. Louis to Roanoke flight tickets
American Airlines
Feb 19
STL2:00 pmLambert-St Louis
5h 30m
1 stop
ROA8:30 pmRoanoke
Feb 23
ROA8:15 amRoanoke
5h 18m
1 stop
STL12:33 pmLambert-St Louis
$279
American Airlines
Feb 13
STL2:00 pmLambert-St Louis
5h 30m
1 stop
ROA8:30 pmRoanoke
Feb 17
ROA8:15 amRoanoke
5h 18m
1 stop
STL12:33 pmLambert-St Louis
$339
American Airlines
Feb 12
STL1:34 pmLambert-St Louis
6h 51m
1 stop
ROA9:25 pmRoanoke
Feb 17
ROA6:04 pmRoanoke
6h 00m
1 stop
STL11:04 pmLambert-St Louis
$412

United Airlines flights from St. Louis to Roanoke

Our best United Airlines deals on St. Louis to Roanoke flight tickets
United Airlines
Feb 17
STL8:30 amLambert-St Louis
4h 42m
1 stop
ROA2:12 pmRoanoke
Feb 21
ROA5:33 pmRoanoke
4h 32m
1 stop
STL9:05 pmLambert-St Louis
$349
United Airlines
Feb 18
STL8:30 amLambert-St Louis
4h 42m
1 stop
ROA2:12 pmRoanoke
Feb 22
ROA6:40 amRoanoke
4h 56m
1 stop
STL10:36 amLambert-St Louis
$350
United Airlines
Feb 5
STL8:30 amLambert-St Louis
4h 39m
1 stop
ROA2:09 pmRoanoke
Feb 7
ROA12:40 pmRoanoke
4h 23m
1 stop
STL4:03 pmLambert-St Louis
$369

momondo Fare Finder

 
Customize your flight search to find flights from St. Louis to Roanoke that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from St. Louis to Roanoke that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 2/19

2:00 pm-8:30 pm

1 stop5h 30m

Roanoke

Mon 2/23

8:15 am-12:33 pm

1 stop5h 18m

$279

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Wed 3/25

6:59 pm-12:04 am

1 stop4h 05m

Roanoke

Wed 4/1

6:00 am-11:09 am

1 stop6h 09m

$303

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Wed 3/25

5:15 pm-10:59 pm

1 stop4h 44m

Roanoke

Mon 3/30

6:00 am-9:05 am

1 stop4h 05m

$304

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Sun 3/1

6:56 pm-12:06 am

1 stop4h 10m

Roanoke

Sun 3/8

6:00 am-11:09 am

1 stop6h 09m

$319

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 4/3

2:00 pm-8:30 pm

1 stop5h 30m

Roanoke

Mon 4/6

5:00 am-8:35 am

1 stop4h 35m

$339

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Tue 2/17

8:30 am-2:12 pm

1 stop4h 42m

Roanoke

Sat 2/21

5:33 pm-9:05 pm

1 stop4h 32m

$349

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Wed 2/18

8:30 am-2:12 pm

1 stop4h 42m

Roanoke

Sun 2/22

6:40 am-10:36 am

1 stop4h 56m

$350

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 3/19

4:51 pm-7:51 pm

1 stop26h 00m

Roanoke

Mon 3/23

4:02 pm-10:32 am

2 stops19h 30m

$401

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Fri 3/6

1:34 pm-9:25 pm

1 stop6h 51m

Roanoke

Sun 3/8

8:15 am-12:44 pm

1 stop5h 29m

$418

St. LouisRoanoke

STL - ROA

STLROA

Lambert-St Louis

Thu 3/19

12:04 pm-7:11 pm

1 stop6h 07m

Roanoke

Mon 3/23

7:51 pm-11:58 pm

1 stop5h 07m

$419

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Roanoke from

How to get the cheapest flight ticket from St. Louis to Roanoke

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between St. Louis and Roanoke?

What is the cheapest month to fly to Roanoke?

The month of January is, on average, the cheapest month to fly to Roanoke from St. Louis, with most prices found around $248. If you aren’t able to travel to Roanoke during the month of January, then flying in July is also cheap. Prices for this month can be found on momondo for an average of $254.

When to book flights from St. Louis to Roanoke

Are you open to changing your travel dates? Check out the ideal times to fly from St. Louis to Roanoke according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap St. Louis to Roanoke (STL to ROA) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from St. Louis to Roanoke

Fastest flight time

4h 05m

Direct flights

None
The fastest flight from St. Louis to Roanoke takes 4h 05m
There are no direct flights from St. Louis to Roanoke. There are no popular flight routes from St. Louis to Roanoke.
Search flight deals

  • How far is Lambert-St Louis to Roanoke by plane?

    The straight-line distance from Lambert-St Louis to Roanoke is 565.9 mi. Typically, this will take 4h 05m by plane in normal conditions.

  • When did momondo last update prices for flights from Lambert-St Louis Airport to Roanoke Airport?

    Prices for flights from Lambert-St Louis Airport to Roanoke Airport were last updated today.

  • How many operators does momondo search for flights from Lambert-St Louis Airport to Roanoke Airport?

  • How old do you have to be to fly from Lambert-St Louis Airport to Roanoke Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Lambert-St Louis Airport to Roanoke Airport.

  • What documentation or ID do you need to fly to Roanoke Airport?

    The necessary travel and health documents for your Roanoke Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from St. Louis to Roanoke?

Best airlines flying from St. Louis to Roanoke

Compare and see reviews for airlines that fly from St. Louis to Roanoke with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.9
8,144 reviews
Search Delta flights
American AirlinesPriceFrom $224Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights
United AirlinesPriceFrom $259Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights

Traveling to a place near Roanoke?

Book flights to Roanoke if you plan to visit one of these locations
Blacksburg
Salem
Christiansburg
Radford
Rocky Mount

Why use momondo?

Why should I use momondo to find a flight deal from St. Louis to Roanoke?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from St. Louis to Roanoke. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from St. Louis to Roanoke with flexible booking policies on momondo?

momondo does allow users to show only those flights to Roanoke from St. Louis which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from St. Louis to Roanoke?

Once all potential St. Louis to Roanoke flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from St. Louis to Roanoke right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of St. Louis to Roanoke flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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