Cheap flights from St. Louis to Charleston from $103

The cheapest month to fly to Charleston from St. Louis is in February. Flight prices, which tend to average around $350, are often lower during this time because this is during the off-season. The month of October is another great option to travel to Charleston, with average flight prices from St. Louis averaging around $352.

The cheapest day to depart from St. Louis to Charleston is on a Tuesday. Travelers who choose to depart for Charleston on a Tuesday will often find tickets for as low as $308. The most expensive day to fly to Charleston is Thursday, with ticket prices averaging around $469.

The cheapest time of day to fly to Charleston is in the afternoon when flights can be purchased for as low as $360. At noon is when there is more demand to fly to Charleston, so prices are often more expensive at around $456 per ticket.

Fly from Lambert-St Louis to Charleston for the best Lambert-St Louis - Charleston flight prices

You are more likely to see cheaper flights to Charleston from St. Louis when booking weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $389 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from St. Louis for as low as $270 on momondo.

There is only 1 cabin class available to choose from on St. Louis to Charleston flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 7% on your flight if you consider stops on a St. Louis to Charleston flight.

As of September 2026, prices for St. Louis to Charleston flights are approximately 30% more expensive when compared to flights at the same time last year.

Delta is the most popular carrier operating from Lambert-St Louis to Charleston

American Airlines, Southwest and Delta are the top three most popular airlines that fly to Charleston from St. Louis according to our data. American Airlines is the first choice among our users, with 38% of people opting to fly with this airline when traveling to Charleston. Keep in mind that there are 5 different airlines that fly to Charleston on a routine basis, so you have a few additional options to choose from.

Atlanta (ATL) was the most common stop: 50% of momondo users choosing 1-stop flights on this route connected there.

Flights via Atlanta (ATL) offer the lowest average round-trip price of $206.

Flights connecting via Charlotte (CLT) have the shortest average one-way travel time: 3h 45m.

Charlotte (CLT) has the shortest average layover time for this route: 0h 54m.