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Cheap flights from South Dakota to Panama City from $339

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Panama City departing on 3/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Dakota to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:01 am - 7:47 pm
FSD
-
ECP
8h 46m
2 stops
Delta Logo
5:30 pm - 10:12 pm
ECP
-
FSD
4h 42m
1 stop
$339Delta
Tue, Mar 10 - Wed, Mar 18
American Airlines Logo
12:14 pm - 10:17 pm
FSD
-
ECP
10h 03m
2 stops
American Airlines Logo
8:20 am - 7:10 pm
ECP
-
FSD
10h 50m
2 stops
$369American Airlines
Tue, Mar 10 - Tue, Mar 17
American Airlines Logo
7:42 pm - 10:01 am
FSD
-
ECP
14h 19m
2 stops
American Airlines Logo
3:38 pm - 9:40 pm
ECP
-
FSD
6h 02m
1 stop
$393American Airlines
Fri, Feb 27 - Fri, Mar 6
American Airlines Logo
7:42 pm - 10:41 am
FSD
-
ECP
14h 59m
1 stop
American Airlines Logo
1:19 pm - 7:10 pm
ECP
-
FSD
5h 51m
1 stop
$396American Airlines
Fri, Feb 27 - Fri, Mar 6
American Airlines Logo
7:42 pm - 10:01 am
FSD
-
ECP
14h 19m
2 stops
American Airlines Logo
7:19 am - 7:10 pm
ECP
-
FSD
11h 51m
2 stops
$398American Airlines
Fri, Feb 27 - Fri, Mar 6
Delta Logo
11:01 am - 7:47 pm
FSD
-
ECP
8h 46m
2 stops
Delta Logo
6:00 am - 11:04 pm
ECP
-
FSD
17h 04m
2 stops
$413Delta
Tue, Mar 10 - Thu, Mar 19
American Airlines Logo
1:22 pm - 9:18 pm
FSD
-
ECP
7h 56m
1 stop
American Airlines Logo
3:00 pm - 10:55 pm
ECP
-
FSD
7h 55m
1 stop
$414American Airlines
Tue, Mar 10 - Wed, Mar 18
American Airlines Logo
6:50 am - 12:44 pm
FSD
-
ECP
5h 54m
1 stop
American Airlines Logo
8:20 am - 7:10 pm
ECP
-
FSD
10h 50m
2 stops
$419American Airlines
Tue, Mar 10 - Tue, Mar 17
American Airlines Logo
12:14 pm - 11:49 pm
FSD
-
ECP
11h 35m
2 stops
American Airlines Logo
3:38 pm - 9:40 pm
ECP
-
FSD
6h 02m
1 stop
$421American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
2:08 pm - 11:49 pm
FSD
-
ECP
9h 41m
2 stops
American Airlines Logo
8:20 am - 7:10 pm
ECP
-
FSD
10h 50m
2 stops
$427American Airlines
Fri, Feb 20 - Tue, Feb 24

Delta flights from South Dakota to Panama City, Florida

Our best Delta deals on South Dakota to Panama City, Florida flight tickets
Delta
Mar 10
FSD11:01 amSioux Falls Joe Foss Field
8h 46m
2 stops
ECP7:47 pmPanama City NW Florida Beaches
Mar 18
ECP5:30 pmPanama City NW Florida Beaches
4h 42m
1 stop
FSD10:12 pmSioux Falls Joe Foss Field
$339
Delta
Mar 10
FSD11:01 amSioux Falls Joe Foss Field
8h 46m
2 stops
ECP7:47 pmPanama City NW Florida Beaches
Mar 19
ECP6:00 amPanama City NW Florida Beaches
17h 04m
2 stops
FSD11:04 pmSioux Falls Joe Foss Field
$413
Delta
Mar 11
FSD8:00 amSioux Falls Joe Foss Field
11h 47m
2 stops
ECP7:47 pmPanama City NW Florida Beaches
Mar 17
ECP5:30 pmPanama City NW Florida Beaches
4h 42m
1 stop
FSD10:12 pmSioux Falls Joe Foss Field
$434

American Airlines flights from South Dakota to Panama City, Florida

Our best American Airlines deals on South Dakota to Panama City, Florida flight tickets
American Airlines
Mar 10
FSD12:14 pmSioux Falls Joe Foss Field
10h 03m
2 stops
ECP10:17 pmPanama City NW Florida Beaches
Mar 17
ECP8:20 amPanama City NW Florida Beaches
10h 50m
2 stops
FSD7:10 pmSioux Falls Joe Foss Field
$369
American Airlines
Feb 27
FSD7:42 pmSioux Falls Joe Foss Field
14h 19m
2 stops
ECP10:01 amPanama City NW Florida Beaches
Mar 6
ECP3:38 pmPanama City NW Florida Beaches
6h 02m
1 stop
FSD9:40 pmSioux Falls Joe Foss Field
$393
American Airlines
Feb 27
FSD7:42 pmSioux Falls Joe Foss Field
14h 59m
1 stop
ECP10:41 amPanama City NW Florida Beaches
Mar 6
ECP1:19 pmPanama City NW Florida Beaches
5h 51m
1 stop
FSD7:10 pmSioux Falls Joe Foss Field
$396

momondo Fare Finder

 
Customize your flight search to find flights from South Dakota to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 8, 2026.
Use the filters below to find and compare flights from South Dakota to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 3/10

11:01 am-7:47 pm

2 stops8h 46m

Panama City NW Florida Beaches

Wed 3/18

5:30 pm-10:12 pm

1 stop4h 42m

$339

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 3/10

12:14 pm-10:17 pm

2 stops10h 03m

Panama City NW Florida Beaches

Tue 3/17

8:20 am-7:10 pm

2 stops10h 50m

$369

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/27

7:42 pm-10:01 am

2 stops14h 19m

Panama City NW Florida Beaches

Fri 3/6

3:38 pm-9:40 pm

1 stop6h 02m

$393

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/27

7:42 pm-10:41 am

1 stop14h 59m

Panama City NW Florida Beaches

Fri 3/6

1:19 pm-7:10 pm

1 stop5h 51m

$396

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/27

7:42 pm-10:01 am

2 stops14h 19m

Panama City NW Florida Beaches

Fri 3/6

7:19 am-7:10 pm

2 stops11h 51m

$398

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 3/10

11:01 am-7:47 pm

2 stops8h 46m

Panama City NW Florida Beaches

Thu 3/19

6:00 am-11:04 pm

2 stops17h 04m

$413

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 3/10

1:22 pm-9:18 pm

1 stop7h 56m

Panama City NW Florida Beaches

Wed 3/18

3:00 pm-10:55 pm

1 stop7h 55m

$414

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 3/10

6:50 am-12:44 pm

1 stop5h 54m

Panama City NW Florida Beaches

Tue 3/17

8:20 am-7:10 pm

2 stops10h 50m

$419

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/20

12:14 pm-11:49 pm

2 stops11h 35m

Panama City NW Florida Beaches

Tue 2/24

3:38 pm-9:40 pm

1 stop6h 02m

$421

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/20

2:08 pm-11:49 pm

2 stops9h 41m

Panama City NW Florida Beaches

Tue 2/24

8:20 am-7:10 pm

2 stops10h 50m

$427

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Dakota to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on South Dakota to Panama City, Florida flights?

You could potentially save up to 55% on your flight if you consider stops on a South Dakota to Panama City, Florida flight.

Cheap South Dakota to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Panama City, Florida

Fastest flight time

5h 31m

Direct flights

None
The fastest flight from South Dakota to Panama City, Florida takes 5h 31m
There are no direct flights from South Dakota to Panama City, Florida. There are no popular flight routes from South Dakota to Panama City, Florida.
Search flight deals

  • When did momondo last update prices for flights from South Dakota to Panama City NW Florida Beaches Airport?

    Prices for flights from South Dakota to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from South Dakota to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Dakota to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Dakota to Panama City, Florida

Compare and see reviews for airlines that fly from South Dakota to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $254Free CancellationRating
7.4
9,257 reviews
Search United Airlines flights
DeltaPriceFrom $264Free CancellationRating
7.9
8,173 reviews
Search Delta flights
American AirlinesPriceFrom $274Free CancellationRating
7.2
11,255 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Dakota to Panama City for you.

Can I find flights from South Dakota to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Dakota to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Dakota to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from South Dakota.

I’m not ready to book a flight from South Dakota to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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