Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from South Dakota to Panama City from $291

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Panama City departing on 9/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Dakota to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:30 am - 12:40 pm
FSD
-
ECP
7h 10m
1 stop
Delta Logo
1:47 pm - 7:49 pm
ECP
-
FSD
6h 02m
1 stop
$291Delta
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:05 pm - 10:56 pm
FSD
-
ECP
9h 51m
2 stops
Delta Logo
1:47 pm - 7:49 pm
ECP
-
FSD
6h 02m
1 stop
$296Delta
Tue, Sep 22 - Sat, Sep 26
Delta Logo
5:30 am - 12:40 pm
FSD
-
ECP
7h 10m
1 stop
Delta Logo
1:47 pm - 7:49 pm
ECP
-
FSD
6h 02m
1 stop
$301Delta
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:05 pm - 10:56 pm
FSD
-
ECP
9h 51m
2 stops
Delta Logo
1:47 pm - 7:49 pm
ECP
-
FSD
6h 02m
1 stop
$306Delta
Tue, Sep 22 - Sat, Sep 26
American Airlines Logo
7:30 am - 2:25 pm
FSD
-
ECP
6h 55m
1 stop
American Airlines Logo
3:15 pm - 10:07 pm
ECP
-
FSD
6h 52m
1 stop
$310American Airlines
Wed, Sep 2 - Sun, Sep 6
Delta Logo
1:05 pm - 10:56 pm
FSD
-
ECP
9h 51m
2 stops
Delta Logo
9:23 am - 3:38 pm
ECP
-
FSD
6h 15m
2 stops
$311Delta
Tue, Sep 22 - Sat, Sep 26
American Airlines Logo
12:57 pm - 10:40 pm
FSD
-
ECP
9h 43m
2 stops
American Airlines Logo
3:15 pm - 10:07 pm
ECP
-
FSD
6h 52m
1 stop
$315American Airlines
Wed, Sep 2 - Sun, Sep 6
United Airlines Logo
11:35 am - 10:18 pm
FSD
-
ECP
10h 43m
2 stops
United Airlines Logo
3:30 pm - 11:44 pm
ECP
-
FSD
8h 14m
1 stop
$340United Airlines
Sat, Oct 17 - Sat, Oct 24
American Airlines Logo
12:57 pm - 10:40 pm
FSD
-
ECP
9h 43m
2 stops
American Airlines Logo
7:10 am - 5:36 pm
ECP
-
FSD
10h 26m
2 stops
$345American Airlines
Wed, Sep 2 - Sun, Sep 6
United Airlines Logo
11:35 am - 10:18 pm
FSD
-
ECP
10h 43m
2 stops
United Airlines Logo
6:20 am - 4:23 pm
ECP
-
FSD
10h 03m
2 stops
$346United Airlines
Sat, Oct 17 - Sat, Oct 24

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Delta flights from South Dakota to Panama City, Florida

Our best Delta deals on South Dakota to Panama City, Florida flight tickets
Delta
Sep 22
FSD5:30 amSioux Falls Joe Foss Field
7h 10m
1 stop
ECP12:40 pmPanama City NW Florida Beaches
Sep 26
ECP1:47 pmPanama City NW Florida Beaches
6h 02m
1 stop
FSD7:49 pmSioux Falls Joe Foss Field
$291
Delta
Sep 22
FSD1:05 pmSioux Falls Joe Foss Field
9h 51m
2 stops
ECP10:56 pmPanama City NW Florida Beaches
Sep 26
ECP1:47 pmPanama City NW Florida Beaches
6h 02m
1 stop
FSD7:49 pmSioux Falls Joe Foss Field
$296
Delta
Sep 22
FSD5:30 amSioux Falls Joe Foss Field
7h 10m
1 stop
ECP12:40 pmPanama City NW Florida Beaches
Sep 26
ECP1:47 pmPanama City NW Florida Beaches
6h 02m
1 stop
FSD7:49 pmSioux Falls Joe Foss Field
$301

American Airlines flights from South Dakota to Panama City, Florida

Our best American Airlines deals on South Dakota to Panama City, Florida flight tickets
American Airlines
Sep 2
FSD7:30 amSioux Falls Joe Foss Field
6h 55m
1 stop
ECP2:25 pmPanama City NW Florida Beaches
Sep 6
ECP3:15 pmPanama City NW Florida Beaches
6h 52m
1 stop
FSD10:07 pmSioux Falls Joe Foss Field
$310
American Airlines
Sep 2
FSD12:57 pmSioux Falls Joe Foss Field
9h 43m
2 stops
ECP10:40 pmPanama City NW Florida Beaches
Sep 6
ECP3:15 pmPanama City NW Florida Beaches
6h 52m
1 stop
FSD10:07 pmSioux Falls Joe Foss Field
$315
American Airlines
Sep 2
FSD12:57 pmSioux Falls Joe Foss Field
9h 43m
2 stops
ECP10:40 pmPanama City NW Florida Beaches
Sep 6
ECP7:10 amPanama City NW Florida Beaches
10h 26m
2 stops
FSD5:36 pmSioux Falls Joe Foss Field
$345

momondo Fare Finder

 
Customize your flight search to find flights from South Dakota to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from South Dakota to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

5:30 am-12:40 pm

1 stop7h 10m

Panama City NW Florida Beaches

Sat 9/26

1:47 pm-7:49 pm

1 stop6h 02m

$291

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

1:05 pm-10:56 pm

2 stops9h 51m

Panama City NW Florida Beaches

Sat 9/26

1:47 pm-7:49 pm

1 stop6h 02m

$296

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

5:30 am-12:40 pm

1 stop7h 10m

Panama City NW Florida Beaches

Sat 9/26

1:47 pm-7:49 pm

1 stop6h 02m

$301

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

1:05 pm-10:56 pm

2 stops9h 51m

Panama City NW Florida Beaches

Sat 9/26

1:47 pm-7:49 pm

1 stop6h 02m

$306

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 9/2

7:30 am-2:25 pm

1 stop6h 55m

Panama City NW Florida Beaches

Sun 9/6

3:15 pm-10:07 pm

1 stop6h 52m

$310

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

1:05 pm-10:56 pm

2 stops9h 51m

Panama City NW Florida Beaches

Sat 9/26

9:23 am-3:38 pm

2 stops6h 15m

$311

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 9/2

12:57 pm-10:40 pm

2 stops9h 43m

Panama City NW Florida Beaches

Sun 9/6

3:15 pm-10:07 pm

1 stop6h 52m

$315

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 10/17

11:35 am-10:18 pm

2 stops10h 43m

Panama City NW Florida Beaches

Sat 10/24

3:30 pm-11:44 pm

1 stop8h 14m

$340

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 9/2

12:57 pm-10:40 pm

2 stops9h 43m

Panama City NW Florida Beaches

Sun 9/6

7:10 am-5:36 pm

2 stops10h 26m

$345

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 10/17

11:35 am-10:18 pm

2 stops10h 43m

Panama City NW Florida Beaches

Sat 10/24

6:20 am-4:23 pm

2 stops10h 03m

$346

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from South Dakota to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Dakota is in January. Flight prices, which tend to average around $0, are often lower during this time because this is during the off-season. The month of March is another great option to travel to Panama City, Florida, with average flight prices from South Dakota averaging around $278.

Can stopping save me money on South Dakota to Panama City, Florida flights?

You could potentially save up to 21% on your flight if you consider stops on a South Dakota to Panama City, Florida flight.

Cheap South Dakota to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Panama City, Florida

Fastest flight time

4h 50m

Direct flights

None
The fastest flight from South Dakota to Panama City, Florida takes 4h 50m
There are no direct flights from South Dakota to Panama City, Florida. There are no popular flight routes from South Dakota to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from South Dakota to Panama City, Florida

  • When did momondo last update prices for flights from South Dakota to Panama City NW Florida Beaches Airport?

    Prices for flights from South Dakota to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from South Dakota to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Dakota to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Dakota to Panama City, Florida

Compare and see reviews for airlines that fly from South Dakota to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $279Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights
DeltaPriceFrom $303Free CancellationRating
7.9
8,394 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Dakota to Panama City for you.

Can I find flights from South Dakota to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Dakota to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Dakota to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from South Dakota.

I’m not ready to book a flight from South Dakota to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 7/9
Thu 7/16
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States