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Cheap flights from South Dakota to Panama City from $264

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from South Dakota to Panama City departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Dakota to Panama City

Cheap round-trip flights

Delta Logo
5:18 am - 3:53 pmFSD-ECP
10h 35m2 stops
Delta Logo
5:00 pm - 11:13 pmECP-FSD
6h 13m1 stop
$264Delta
Find Deal
Sat, Dec 6 - Tue, Dec 9
Delta Logo
5:18 am - 12:47 pmFSD-ECP
7h 29m2 stops
Delta Logo
1:32 pm - 11:11 pmECP-FSD
9h 39m2 stops
$269Delta
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
1:28 pm - 8:31 pmFSD-ECP
7h 03m1 stop
American Airlines Logo
2:43 pm - 10:11 pmECP-FSD
7h 28m2 stops
$321American Airlines
Find Deal
Tue, Jan 13 - Tue, Jan 20
United Airlines Logo
11:19 am - 9:48 pmFSD-ECP
10h 29m2 stops
United Airlines Logo
1:55 pm - 10:22 pmECP-FSD
8h 27m1 stop
$324United Airlines
Find Deal
Tue, Oct 7 - Sat, Oct 11
Delta Logo
1:20 pm - 10:42 pmFSD-ECP
9h 22m2 stops
Delta Logo
4:45 pm - 10:16 pmECP-FSD
5h 31m1 stop
$329Delta
Find Deal
Tue, Jan 13 - Tue, Jan 20
American Airlines Logo
1:09 pm - 7:11 pmFSD-ECP
6h 02m1 stop
American Airlines Logo
6:33 am - 12:18 pmECP-FSD
5h 45m1 stop
$339American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
1:33 pm - 7:32 pmFSD-ECP
5h 59m1 stop
American Airlines Logo
6:31 am - 12:42 pmECP-FSD
6h 11m1 stop
$352American Airlines
Find Deal
Tue, Oct 7 - Sat, Oct 11
Delta Logo
1:20 pm - 10:42 pmFSD-ECP
9h 22m2 stops
Delta Logo
4:45 pm - 10:16 pmECP-FSD
5h 31m1 stop
$404Delta
Find Deal
Mon, Feb 2 - Sat, Feb 7
United Airlines Logo
11:52 am - 9:48 pmFSD-ECP
9h 56m2 stops
United Airlines Logo
11:10 am - 10:22 pmECP-FSD
11h 12m2 stops
$423United Airlines
Find Deal
Tue, Oct 7 - Sat, Oct 11
United Airlines Logo
8:00 am - 9:48 pmFSD-ECP
13h 48m3 stops
United Airlines Logo
1:55 pm - 10:42 amECP-FSD
20h 47m2 stops
$534United Airlines
Find Deal
Tue, Oct 7 - Sat, Oct 11

American Airlines flights from South Dakota to Panama City, Florida

Our best American Airlines deals on South Dakota to Panama City, Florida flight tickets
American Airlines
Jan 13
FSD1:28 pmSioux Falls Joe Foss Field
7h 03m
1 stop
ECP8:31 pmPanama City NW Florida Beaches
Jan 20
ECP2:43 pmPanama City NW Florida Beaches
7h 28m
2 stops
FSD10:11 pmSioux Falls Joe Foss Field
$321
Find similar
American Airlines
Dec 6
FSD1:09 pmSioux Falls Joe Foss Field
6h 02m
1 stop
ECP7:11 pmPanama City NW Florida Beaches
Dec 9
ECP6:33 amPanama City NW Florida Beaches
5h 45m
1 stop
FSD12:18 pmSioux Falls Joe Foss Field
$339
Find similar
American Airlines
Sep 23
FSD1:19 pmSioux Falls Joe Foss Field
7h 53m
1 stop
ECP9:12 pmPanama City NW Florida Beaches
Sep 27
ECP6:32 amPanama City NW Florida Beaches
6h 06m
1 stop
FSD12:38 pmSioux Falls Joe Foss Field
$349
Find similar

United Airlines flights from South Dakota to Panama City, Florida

Our best United Airlines deals on South Dakota to Panama City, Florida flight tickets
United Airlines
Oct 7
FSD11:19 amSioux Falls Joe Foss Field
10h 29m
2 stops
ECP9:48 pmPanama City NW Florida Beaches
Oct 11
ECP1:55 pmPanama City NW Florida Beaches
8h 27m
1 stop
FSD10:22 pmSioux Falls Joe Foss Field
$324
Find similar
United Airlines
Oct 7
FSD11:52 amSioux Falls Joe Foss Field
9h 56m
2 stops
ECP9:48 pmPanama City NW Florida Beaches
Oct 11
ECP11:10 amPanama City NW Florida Beaches
11h 12m
2 stops
FSD10:22 pmSioux Falls Joe Foss Field
$423
Find similar
United Airlines
Oct 7
FSD8:00 amSioux Falls Joe Foss Field
13h 48m
3 stops
ECP9:48 pmPanama City NW Florida Beaches
Oct 11
ECP1:55 pmPanama City NW Florida Beaches
20h 47m
2 stops
FSD10:42 amSioux Falls Joe Foss Field
$534
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Dakota to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 22, 2025.
Use the filters below to find and compare flights from South Dakota to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

5:18 am-3:53 pm

2 stops10h 35m

Panama City NW Florida Beaches

Tue 12/9

5:00 pm-11:13 pm

1 stop6h 13m

$264

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

5:18 am-12:47 pm

2 stops7h 29m

Panama City NW Florida Beaches

Tue 12/9

1:32 pm-11:11 pm

2 stops9h 39m

$269

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 1/13

1:28 pm-8:31 pm

1 stop7h 03m

Panama City NW Florida Beaches

Tue 1/20

2:43 pm-10:11 pm

2 stops7h 28m

$321

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 10/7

11:19 am-9:48 pm

2 stops10h 29m

Panama City NW Florida Beaches

Sat 10/11

1:55 pm-10:22 pm

1 stop8h 27m

$324

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 1/13

1:20 pm-10:42 pm

2 stops9h 22m

Panama City NW Florida Beaches

Tue 1/20

4:45 pm-10:16 pm

1 stop5h 31m

$329

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

1:09 pm-7:11 pm

1 stop6h 02m

Panama City NW Florida Beaches

Tue 12/9

6:33 am-12:18 pm

1 stop5h 45m

$339

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 10/7

1:33 pm-7:32 pm

1 stop5h 59m

Panama City NW Florida Beaches

Sat 10/11

6:31 am-12:42 pm

1 stop6h 11m

$352

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 2/2

1:20 pm-10:42 pm

2 stops9h 22m

Panama City NW Florida Beaches

Sat 2/7

4:45 pm-10:16 pm

1 stop5h 31m

$404

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 10/7

11:52 am-9:48 pm

2 stops9h 56m

Panama City NW Florida Beaches

Sat 10/11

11:10 am-10:22 pm

2 stops11h 12m

$423

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 10/7

8:00 am-9:48 pm

3 stops13h 48m

Panama City NW Florida Beaches

Sat 10/11

1:55 pm-10:42 am

2 stops20h 47m

$534

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from South Dakota to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Dakota is in January. Flight prices, which tend to average around $333, are often lower during this time because this is during the off-season. The month of July is another great option to travel to Panama City, Florida, with average flight prices from South Dakota averaging around $352.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Thursday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $332. On the other hand, Wednesday is the most expensive day to depart from South Dakota because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $555.

Cheap South Dakota to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Dakota to Panama City, Florida

Direct flights

None
There are no direct flights from South Dakota to Panama City, Florida. There are no popular flight routes from South Dakota to Panama City, Florida.
Search flight deals

  • When did momondo last update prices for flights from South Dakota to Panama City NW Florida Beaches Airport?

    Prices for flights from South Dakota to Panama City NW Florida Beaches Airport were last updated today.

  • How many operators does momondo search for flights from South Dakota to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Dakota to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Dakota to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Dakota to Panama City, Florida

Compare and see reviews for airlines that fly from South Dakota to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $254Free CancellationRating
7.4
8,922 reviews
Search United Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
7,971 reviews
Search Delta flights
American AirlinesPriceFrom $274Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Dakota to Panama City?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from South Dakota to Panama City for you.

Can I find flights from South Dakota to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Dakota to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Dakota to Panama City?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Panama City from South Dakota.

I’m not ready to book a flight from South Dakota to Panama City right now. Can momondo alert me if prices change?

Price alerts on flights to Panama City from South Dakota are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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