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Cheap flights from South Carolina to Panama City from $124

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 5/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:55 am - 1:52 pm
CAE
-
ECP
2h 57m
1 stop
Delta Logo
6:00 am - 11:17 am
ECP
-
CAE
4h 17m
1 stop
$249Delta
Tue, Jun 30 - Sat, Jul 4
Southwest Logo
10:55 am - 6:15 pm
CLT
-
ECP
8h 20m
1 stop
Southwest Logo
7:55 am - 6:40 pm
ECP
-
CLT
9h 45m
1 stop
$290Southwest
Sat, Apr 18 - Wed, Apr 22
Delta Logo
6:00 am - 8:35 am
MYR
-
ECP
3h 35m
1 stop
Delta Logo
9:17 am - 3:21 pm
ECP
-
MYR
5h 04m
1 stop
$291Delta
Tue, May 5 - Tue, May 12
Southwest Logo
12:25 pm - 8:35 pm
GSP
-
ECP
9h 10m
1 stop
Southwest Logo
7:00 am - 12:00 pm
ECP
-
GSP
4h 00m
1 stop
$292Southwest
Mon, Mar 30 - Wed, Apr 1
Southwest Logo
12:25 pm - 8:35 pm
GSP
-
ECP
9h 10m
1 stop
Southwest Logo
1:45 pm - 10:40 pm
ECP
-
GSP
7h 55m
2 stops
$298Southwest
Mon, Mar 30 - Wed, Apr 1
Southwest Logo
6:45 am - 9:30 am
GSP
-
ECP
3h 45m
1 stop
Southwest Logo
7:15 am - 12:10 pm
ECP
-
GSP
3h 55m
1 stop
$301Southwest
Tue, May 19 - Wed, May 27
American Airlines Logo
9:20 am - 10:03 am
CLT
-
ECP
1h 43mnonstop
American Airlines Logo
4:40 pm - 7:28 pm
ECP
-
CLT
1h 48mnonstop
$313American Airlines
Sat, Apr 18 - Tue, Apr 21
American Airlines Logo
8:45 am - 9:36 am
CLT
-
ECP
1h 51mnonstop
American Airlines Logo
8:20 am - 11:09 am
ECP
-
CLT
1h 49mnonstop
$336American Airlines
Tue, Mar 24 - Tue, Mar 31
United Airlines Logo
6:30 am - 1:09 pm
CAE
-
ECP
7h 39m
1 stop
United Airlines Logo
3:10 pm - 2:10 pm
ECP
-
CAE
22h 00m
2 stops
$567United Airlines
Tue, Aug 11 - Tue, Aug 18
United Airlines Logo
6:15 am - 11:19 am
CAE
-
ECP
6h 04m
1 stop
United Airlines Logo
2:10 pm - 8:50 pm
ECP
-
CAE
5h 40m
1 stop
$631United Airlines
Sat, Mar 14 - Wed, Mar 18

Delta flights from South Carolina to Panama City, Florida

Our best Delta deals on South Carolina to Panama City, Florida flight tickets
Delta
Jun 30
CAE11:55 amColumbia Metropolitan
2h 57m
1 stop
ECP1:52 pmPanama City NW Florida Beaches
Jul 4
ECP6:00 amPanama City NW Florida Beaches
4h 17m
1 stop
CAE11:17 amColumbia Metropolitan
$249
Delta
May 5
MYR6:00 amMyrtle Beach Intl
3h 35m
1 stop
ECP8:35 amPanama City NW Florida Beaches
May 12
ECP9:17 amPanama City NW Florida Beaches
5h 04m
1 stop
MYR3:21 pmMyrtle Beach Intl
$291
Delta
May 13
CHS8:20 amCharleston
5h 30m
1 stop
ECP12:50 pmPanama City NW Florida Beaches
May 20
ECP5:29 pmPanama City NW Florida Beaches
4h 27m
1 stop
CHS10:56 pmCharleston
$315

Southwest flights from South Carolina to Panama City, Florida

Our best Southwest deals on South Carolina to Panama City, Florida flight tickets
Southwest
Jul 11
CLT11:35 amCharlotte Douglas
8h 25m
1 stop
ECP7:00 pmPanama City NW Florida Beaches
Jul 18
ECP6:35 amPanama City NW Florida Beaches
9h 45m
1 stop
CLT5:20 pmCharlotte Douglas
$282
Southwest
Jul 11
CLT1:05 pmCharlotte Douglas
9h 50m
2 stops
ECP9:55 pmPanama City NW Florida Beaches
Jul 18
ECP6:35 amPanama City NW Florida Beaches
9h 45m
1 stop
CLT5:20 pmCharlotte Douglas
$287
Southwest
Apr 18
CLT10:55 amCharlotte Douglas
8h 20m
1 stop
ECP6:15 pmPanama City NW Florida Beaches
Apr 21
ECP7:55 amPanama City NW Florida Beaches
9h 45m
1 stop
CLT6:40 pmCharlotte Douglas
$290

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 1, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Tue 6/30

11:55 am-1:52 pm

1 stop2h 57m

Panama City NW Florida Beaches

Sat 7/4

6:00 am-11:17 am

1 stop4h 17m

$249

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Sat 4/18

10:55 am-6:15 pm

1 stop8h 20m

Panama City NW Florida Beaches

Wed 4/22

7:55 am-6:40 pm

1 stop9h 45m

$290

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Tue 5/5

6:00 am-8:35 am

1 stop3h 35m

Panama City NW Florida Beaches

Tue 5/12

9:17 am-3:21 pm

1 stop5h 04m

$291

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 3/30

12:25 pm-8:35 pm

1 stop9h 10m

Panama City NW Florida Beaches

Wed 4/1

7:00 am-12:00 pm

1 stop4h 00m

$292

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Mon 3/30

12:25 pm-8:35 pm

1 stop9h 10m

Panama City NW Florida Beaches

Wed 4/1

1:45 pm-10:40 pm

2 stops7h 55m

$298

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Tue 5/19

6:45 am-9:30 am

1 stop3h 45m

Panama City NW Florida Beaches

Wed 5/27

7:15 am-12:10 pm

1 stop3h 55m

$301

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Sat 4/18

9:20 am-10:03 am

Nonstop1h 43m

Panama City NW Florida Beaches

Tue 4/21

4:40 pm-7:28 pm

Nonstop1h 48m

$313

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Tue 3/24

8:45 am-9:36 am

Nonstop1h 51m

Panama City NW Florida Beaches

Tue 3/31

8:20 am-11:09 am

Nonstop1h 49m

$336

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Tue 8/11

6:30 am-1:09 pm

1 stop7h 39m

Panama City NW Florida Beaches

Tue 8/18

3:10 pm-2:10 pm

2 stops22h 00m

$567

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Sat 3/14

6:15 am-11:19 am

1 stop6h 04m

Panama City NW Florida Beaches

Wed 3/18

2:10 pm-8:50 pm

1 stop5h 40m

$631

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Carolina is in March. Flight prices, which tend to average around $298, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Panama City, Florida, with average flight prices from South Carolina averaging around $304.

Cheap South Carolina to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City, Florida

Fastest flight time

1h 49m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The fastest flight from South Carolina to Panama City, Florida takes 1h 49m
Direct flights go from South Carolina to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From South Carolina there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Panama City NW Florida Beaches Airport?

    Prices for flights from South Carolina to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Carolina to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Panama City, Florida

Compare and see reviews for airlines that fly from South Carolina to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $207Free CancellationRating
7.9
8,244 reviews
Search Delta flights
American AirlinesPriceFrom $272Free CancellationRating
7.1
11,370 reviews
Search American Airlines flights
SouthwestPriceFrom $283Free CancellationRating
8.0
4,303 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

It is quick and easy to find South Carolina to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Panama City?

momondo helps you find the best flight between South Carolina and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South Carolina to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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