Latest deals
Insights
FAQs
Reviews
Price Alerts

Cheap flights from South Carolina to Panama City from $145

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 8/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:00 am - 8:18 am
MYR
-
ECP
3h 18m
1 stop
Delta Logo
5:30 pm - 9:42 pm
ECP
-
MYR
3h 12m
1 stop
$273Delta
Sat, Sep 12 - Sat, Sep 19
Delta Logo
5:20 pm - 9:40 pm
GSP
-
ECP
5h 20m
1 stop
Delta Logo
7:35 am - 12:41 pm
ECP
-
GSP
4h 06m
1 stop
$273Delta
Sat, Sep 5 - Sun, Sep 6
Southwest Logo
11:00 am - 3:00 pm
MYR
-
ECP
5h 00m
1 stop
Southwest Logo
7:45 am - 7:20 pm
ECP
-
MYR
10h 35m
1 stop
$278Southwest
Wed, Aug 19 - Wed, Aug 26
Southwest Logo
6:45 am - 11:05 am
GSP
-
ECP
5h 20m
1 stop
Southwest Logo
7:15 am - 7:00 pm
ECP
-
GSP
10h 45m
2 stops
$278Southwest
Sat, Aug 15 - Sat, Aug 22
Southwest Logo
11:00 am - 6:45 pm
MYR
-
ECP
8h 45m
2 stops
Southwest Logo
10:30 am - 7:20 pm
ECP
-
MYR
7h 50m
2 stops
$283Southwest
Wed, Aug 19 - Wed, Aug 26
Southwest Logo
6:45 am - 2:55 pm
GSP
-
ECP
9h 10m
2 stops
Southwest Logo
7:15 am - 7:00 pm
ECP
-
GSP
10h 45m
2 stops
$283Southwest
Sat, Aug 15 - Sat, Aug 22
American Airlines Logo
7:33 pm - 10:40 pm
MYR
-
ECP
4h 07m
1 stop
American Airlines Logo
5:48 pm - 10:38 pm
ECP
-
MYR
3h 50m
1 stop
$289American Airlines
Sat, Aug 22 - Sat, Aug 29
Delta Logo
3:53 pm - 9:03 pm
CAE
-
ECP
6h 10m
1 stop
Delta Logo
6:00 am - 11:12 am
ECP
-
CAE
4h 12m
1 stop
$289Delta
Thu, Sep 17 - Sun, Sep 20
American Airlines Logo
7:42 pm - 10:40 pm
CAE
-
ECP
3h 58m
1 stop
American Airlines Logo
6:40 am - 1:24 pm
ECP
-
CAE
5h 44m
1 stop
$389American Airlines
Fri, Aug 7 - Tue, Aug 11
United Airlines Logo
6:25 am - 1:06 pm
CAE
-
ECP
7h 41m
1 stop
United Airlines Logo
1:47 pm - 9:28 pm
ECP
-
CAE
6h 41m
1 stop
$534United Airlines
Thu, Aug 20 - Thu, Aug 27

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Delta flights from South Carolina to Panama City, Florida

Our best Delta deals on South Carolina to Panama City, Florida flight tickets
Delta
Sep 5
GSP5:20 pmGreenville
5h 20m
1 stop
ECP9:40 pmPanama City NW Florida Beaches
Sep 6
ECP7:35 amPanama City NW Florida Beaches
4h 06m
1 stop
GSP12:41 pmGreenville
$273
Delta
Sep 17
CAE3:53 pmColumbia Metropolitan
6h 10m
1 stop
ECP9:03 pmPanama City NW Florida Beaches
Sep 20
ECP6:00 amPanama City NW Florida Beaches
4h 12m
1 stop
CAE11:12 amColumbia Metropolitan
$289
Delta
Aug 31
GSP1:28 pmGreenville
6h 07m
1 stop
ECP6:35 pmPanama City NW Florida Beaches
Sep 6
ECP6:00 amPanama City NW Florida Beaches
5h 41m
1 stop
GSP12:41 pmGreenville
$294

Southwest flights from South Carolina to Panama City, Florida

Our best Southwest deals on South Carolina to Panama City, Florida flight tickets
Southwest
Aug 19
MYR11:00 amMyrtle Beach Intl
5h 00m
1 stop
ECP3:00 pmPanama City NW Florida Beaches
Aug 26
ECP7:45 amPanama City NW Florida Beaches
10h 35m
1 stop
MYR7:20 pmMyrtle Beach Intl
$278
Southwest
Aug 19
MYR11:00 amMyrtle Beach Intl
8h 45m
2 stops
ECP6:45 pmPanama City NW Florida Beaches
Aug 26
ECP10:30 amPanama City NW Florida Beaches
7h 50m
2 stops
MYR7:20 pmMyrtle Beach Intl
$283
Southwest
Aug 18
MYR8:15 amMyrtle Beach Intl
10h 55m
2 stops
ECP6:10 pmPanama City NW Florida Beaches
Aug 24
ECP7:05 amPanama City NW Florida Beaches
6h 40m
1 stop
MYR2:45 pmMyrtle Beach Intl
$294

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 21, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Sat 9/12

6:00 am-8:18 am

1 stop3h 18m

Panama City NW Florida Beaches

Sat 9/19

5:30 pm-9:42 pm

1 stop3h 12m

$273

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 9/5

5:20 pm-9:40 pm

1 stop5h 20m

Panama City NW Florida Beaches

Sun 9/6

7:35 am-12:41 pm

1 stop4h 06m

$273

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Wed 8/19

11:00 am-3:00 pm

1 stop5h 00m

Panama City NW Florida Beaches

Wed 8/26

7:45 am-7:20 pm

1 stop10h 35m

$278

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 8/15

6:45 am-11:05 am

1 stop5h 20m

Panama City NW Florida Beaches

Sat 8/22

7:15 am-7:00 pm

2 stops10h 45m

$278

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Wed 8/19

11:00 am-6:45 pm

2 stops8h 45m

Panama City NW Florida Beaches

Wed 8/26

10:30 am-7:20 pm

2 stops7h 50m

$283

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sat 8/15

6:45 am-2:55 pm

2 stops9h 10m

Panama City NW Florida Beaches

Sat 8/22

7:15 am-7:00 pm

2 stops10h 45m

$283

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Sat 8/22

7:33 pm-10:40 pm

1 stop4h 07m

Panama City NW Florida Beaches

Sat 8/29

5:48 pm-10:38 pm

1 stop3h 50m

$289

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Thu 9/17

3:53 pm-9:03 pm

1 stop6h 10m

Panama City NW Florida Beaches

Sun 9/20

6:00 am-11:12 am

1 stop4h 12m

$289

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Fri 8/7

7:42 pm-10:40 pm

1 stop3h 58m

Panama City NW Florida Beaches

Tue 8/11

6:40 am-1:24 pm

1 stop5h 44m

$389

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Thu 8/20

6:25 am-1:06 pm

1 stop7h 41m

Panama City NW Florida Beaches

Thu 8/27

1:47 pm-9:28 pm

1 stop6h 41m

$534

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Carolina is in January. Flight prices, which tend to average around $361, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Panama City, Florida, with average flight prices from South Carolina averaging around $381.

Cheap South Carolina to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City, Florida

Fastest flight time

2h 58m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The fastest flight from South Carolina to Panama City, Florida takes 2h 58m
Direct flights go from South Carolina to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From South Carolina there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from South Carolina to Panama City, Florida

  • When did momondo last update prices for flights from South Carolina to Panama City NW Florida Beaches Airport?

    Prices for flights from South Carolina to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Carolina to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Panama City, Florida

Compare and see reviews for airlines that fly from South Carolina to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $207Free CancellationRating
7.8
8,472 reviews
Search Delta flights
SouthwestPriceFrom $283Free CancellationRating
8.0
4,239 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

It is quick and easy to find South Carolina to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Panama City?

momondo helps you find the best flight between South Carolina and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South Carolina to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 8/20
Thu 8/27
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States