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Cheap flights from South Carolina to Panama City from $130

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 1/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:25 am - 9:12 amCLT-ECP
4h 47m1 stop
Delta Logo
7:20 am - 1:38 pmECP-CLT
5h 18m1 stop
$249Delta
Find Deal
Fri, Jan 16 - Mon, Jan 19
Delta Logo
5:40 am - 8:41 amGSP-ECP
4h 01m1 stop
Delta Logo
6:00 am - 11:05 amECP-GSP
4h 05m1 stop
$249Delta
Find Deal
Tue, Feb 24 - Wed, Feb 25
Delta Logo
10:25 am - 12:45 pmCHS-ECP
3h 20m1 stop
Delta Logo
6:00 am - 12:05 pmECP-CHS
5h 05m1 stop
$253Delta
Find Deal
Tue, Jan 6 - Sat, Jan 10
Delta Logo
6:30 am - 9:12 amCHS-ECP
3h 42m1 stop
Delta Logo
6:00 am - 11:48 amECP-CHS
4h 48m1 stop
$265Delta
Find Deal
Wed, Jan 14 - Sun, Jan 18
American Airlines Logo
6:00 am - 5:33 pmCHS-ECP
12h 33m2 stops
American Airlines Logo
12:03 pm - 7:02 pmECP-CHS
5h 59m1 stop
$270American Airlines
Find Deal
Wed, Jan 14 - Sun, Jan 18
Southwest Logo
7:00 am - 2:40 pmCLT-ECP
8h 40m1 stop
Southwest Logo
7:30 am - 12:15 pmECP-CLT
3h 45m1 stop
$291Southwest
Find Deal
Mon, Dec 15 - Thu, Dec 18
Southwest Logo
11:05 am - 6:10 pmCLT-ECP
8h 05m1 stop
Southwest Logo
10:30 am - 5:20 pmECP-CLT
5h 50m1 stop
$296Southwest
Find Deal
Thu, Jan 29 - Mon, Feb 2
Southwest Logo
11:05 am - 6:10 pmCLT-ECP
8h 05m1 stop
Southwest Logo
7:15 am - 12:15 pmECP-CLT
4h 00m1 stop
$299Southwest
Find Deal
Wed, Feb 25 - Sun, Mar 1
American Airlines Logo
10:19 pm - 11:10 pmCLT-ECP
1h 51mnonstop
American Airlines Logo
10:26 am - 1:13 pmECP-CLT
1h 47mnonstop
$301American Airlines
Find Deal
Mon, Dec 15 - Mon, Dec 22
American Airlines Logo
6:23 am - 11:38 amMYR-ECP
6h 15m1 stop
American Airlines Logo
7:15 am - 2:04 pmECP-MYR
5h 49m1 stop
$308American Airlines
Find Deal
Mon, Dec 15 - Fri, Dec 19

Delta flights from South Carolina to Panama City, Florida

Our best Delta deals on South Carolina to Panama City, Florida flight tickets
Delta
Jan 16
CLT5:25 amCharlotte Douglas
4h 47m
1 stop
ECP9:12 amPanama City NW Florida Beaches
Jan 19
ECP7:20 amPanama City NW Florida Beaches
5h 18m
1 stop
CLT1:38 pmCharlotte Douglas
$249
Find similar
Delta
Jan 6
CHS5:25 amCharleston
4h 47m
1 stop
ECP9:12 amPanama City NW Florida Beaches
Jan 10
ECP7:20 amPanama City NW Florida Beaches
5h 17m
1 stop
CHS1:37 pmCharleston
$253
Find similar
Delta
Jan 14
CHS6:30 amCharleston
3h 42m
1 stop
ECP9:12 amPanama City NW Florida Beaches
Jan 18
ECP6:00 amPanama City NW Florida Beaches
4h 48m
1 stop
CHS11:48 amCharleston
$265
Find similar

American Airlines flights from South Carolina to Panama City, Florida

Our best American Airlines deals on South Carolina to Panama City, Florida flight tickets
American Airlines
Jan 14
CHS6:00 amCharleston
12h 33m
2 stops
ECP5:33 pmPanama City NW Florida Beaches
Jan 18
ECP12:03 pmPanama City NW Florida Beaches
5h 59m
1 stop
CHS7:02 pmCharleston
$270
Find similar
American Airlines
Nov 24
CLT10:19 pmCharlotte Douglas
1h 56m
ECP11:15 pmPanama City NW Florida Beaches
Dec 16
ECP8:30 amPanama City NW Florida Beaches
1h 52m
CLT11:22 amCharlotte Douglas
$281
Find similar
American Airlines
Dec 15
CLT10:19 pmCharlotte Douglas
1h 51m
ECP11:10 pmPanama City NW Florida Beaches
Dec 22
ECP10:26 amPanama City NW Florida Beaches
1h 47m
CLT1:13 pmCharlotte Douglas
$301
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 22, 2025.
Use the filters below to find and compare flights from South Carolina to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Fri 1/16

5:25 am-9:12 am

1 stop4h 47m

Panama City NW Florida Beaches

Mon 1/19

7:20 am-1:38 pm

1 stop5h 18m

$249

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Tue 2/24

5:40 am-8:41 am

1 stop4h 01m

Panama City NW Florida Beaches

Wed 2/25

6:00 am-11:05 am

1 stop4h 05m

$249

CharlestonPanama City

CHS - ECP

CHSECP

Charleston

Tue 1/6

10:25 am-12:45 pm

1 stop3h 20m

Panama City NW Florida Beaches

Sat 1/10

6:00 am-12:05 pm

1 stop5h 05m

$253

CharlestonPanama City

CHS - ECP

CHSECP

Charleston

Wed 1/14

6:30 am-9:12 am

1 stop3h 42m

Panama City NW Florida Beaches

Sun 1/18

6:00 am-11:48 am

1 stop4h 48m

$265

CharlestonPanama City

CHS - ECP

CHSECP

Charleston

Wed 1/14

6:00 am-5:33 pm

2 stops12h 33m

Panama City NW Florida Beaches

Sun 1/18

12:03 pm-7:02 pm

1 stop5h 59m

$270

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Mon 12/15

7:00 am-2:40 pm

1 stop8h 40m

Panama City NW Florida Beaches

Thu 12/18

7:30 am-12:15 pm

1 stop3h 45m

$291

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Thu 1/29

11:05 am-6:10 pm

1 stop8h 05m

Panama City NW Florida Beaches

Mon 2/2

10:30 am-5:20 pm

1 stop5h 50m

$296

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Wed 2/25

11:05 am-6:10 pm

1 stop8h 05m

Panama City NW Florida Beaches

Sun 3/1

7:15 am-12:15 pm

1 stop4h 00m

$299

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Mon 12/15

10:19 pm-11:10 pm

Nonstop1h 51m

Panama City NW Florida Beaches

Mon 12/22

10:26 am-1:13 pm

Nonstop1h 47m

$301

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Mon 12/15

6:23 am-11:38 am

1 stop6h 15m

Panama City NW Florida Beaches

Fri 12/19

7:15 am-2:04 pm

1 stop5h 49m

$308

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Carolina is in March. Flight prices, which tend to average around $216, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Panama City, Florida, with average flight prices from South Carolina averaging around $301.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Saturday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $344. On the other hand, Tuesday is the most expensive day to depart from South Carolina because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $641.

Cheap South Carolina to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City, Florida

Fastest flight time

1h 29m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The fastest flight from South Carolina to Panama City, Florida takes 1h 29m
Direct flights go from South Carolina to Panama City, Florida every day.
There is 1 airport near Panama City, Florida: Panama City NW Florida Beaches (ECP)
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  • When did momondo last update prices for flights from South Carolina to Panama City NW Florida Beaches Airport?

    Prices for flights from South Carolina to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Carolina to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Panama City, Florida

Compare and see reviews for airlines that fly from South Carolina to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $207Free CancellationRating
7.9
8,002 reviews
Search Delta flights
American AirlinesPriceFrom $216Free CancellationRating
7.2
11,048 reviews
Search American Airlines flights
SouthwestPriceFrom $283Free CancellationRating
8.0
4,252 reviews
Search Southwest flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

It is quick and easy to find South Carolina to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Panama City?

momondo helps you find the best flight between South Carolina and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South Carolina to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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