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Cheap flights from South Carolina to Panama City from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 6/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:10 pm - 11:38 pm
MYR
-
ECP
6h 28m
1 stop
American Airlines Logo
5:48 pm - 10:38 pm
ECP
-
MYR
3h 50m
1 stop
$257American Airlines
Thu, Aug 20 - Mon, Aug 24
Delta Logo
5:45 am - 8:15 am
GSP
-
ECP
3h 30m
1 stop
Delta Logo
6:00 am - 12:50 pm
ECP
-
GSP
5h 50m
1 stop
$259Delta
Fri, Sep 11 - Tue, Sep 15
Delta Logo
5:46 am - 8:31 am
GSP
-
ECP
3h 45m
1 stop
Delta Logo
6:00 am - 12:41 pm
ECP
-
GSP
5h 41m
1 stop
$301Delta
Thu, Aug 13 - Sun, Aug 16
Delta Logo
11:44 am - 4:23 pm
GSP
-
ECP
5h 39m
1 stop
Delta Logo
9:19 am - 2:51 pm
ECP
-
GSP
4h 32m
1 stop
$303Delta
Tue, Jun 23 - Tue, Jun 30
Delta Logo
5:51 pm - 11:07 pm
CAE
-
ECP
6h 16m
1 stop
Delta Logo
6:00 am - 1:02 pm
ECP
-
CAE
6h 02m
1 stop
$304Delta
Sat, Jun 20 - Thu, Jun 25
American Airlines Logo
6:06 pm - 11:40 pm
MYR
-
ECP
6h 34m
1 stop
American Airlines Logo
4:17 pm - 9:43 pm
ECP
-
MYR
4h 26m
1 stop
$307American Airlines
Tue, Jun 30 - Tue, Jul 7
Southwest Logo
8:25 am - 1:55 pm
CLT
-
ECP
6h 30m
1 stop
Southwest Logo
1:30 pm - 6:40 pm
ECP
-
CLT
4h 10m
1 stop
$308Southwest
Sat, Aug 29 - Mon, Aug 31
Delta Logo
4:15 pm - 6:59 pm
CHS
-
ECP
3h 44m
1 stop
Delta Logo
7:35 am - 1:25 pm
ECP
-
CHS
4h 50m
1 stop
$309Delta
Sat, Sep 19 - Sat, Sep 26
Southwest Logo
8:30 am - 4:45 pm
MYR
-
ECP
9h 15m
2 stops
Southwest Logo
2:25 pm - 8:35 pm
ECP
-
MYR
5h 10m
1 stop
$312Southwest
Wed, Jul 15 - Wed, Jul 22
United Airlines Logo
6:25 am - 1:24 pm
CAE
-
ECP
7h 59m
1 stop
United Airlines Logo
2:05 pm - 9:16 pm
ECP
-
CAE
6h 11m
1 stop
$753United Airlines
Thu, Jul 2 - Wed, Jul 8

American Airlines flights from South Carolina to Panama City, Florida

Our best American Airlines deals on South Carolina to Panama City, Florida flight tickets
American Airlines
Aug 20
MYR6:10 pmMyrtle Beach Intl
6h 28m
1 stop
ECP11:38 pmPanama City NW Florida Beaches
Aug 24
ECP5:48 pmPanama City NW Florida Beaches
3h 50m
1 stop
MYR10:38 pmMyrtle Beach Intl
$257
American Airlines
Jun 30
MYR6:06 pmMyrtle Beach Intl
6h 34m
1 stop
ECP11:40 pmPanama City NW Florida Beaches
Jul 7
ECP4:17 pmPanama City NW Florida Beaches
4h 26m
1 stop
MYR9:43 pmMyrtle Beach Intl
$307
American Airlines
Jul 1
GSP5:15 amGreenville
6h 13m
1 stop
ECP10:28 amPanama City NW Florida Beaches
Jul 7
ECP6:54 pmPanama City NW Florida Beaches
3h 57m
1 stop
GSP11:51 pmGreenville
$338

Delta flights from South Carolina to Panama City, Florida

Our best Delta deals on South Carolina to Panama City, Florida flight tickets
Delta
Sep 11
GSP5:45 amGreenville
3h 30m
1 stop
ECP8:15 amPanama City NW Florida Beaches
Sep 15
ECP6:00 amPanama City NW Florida Beaches
5h 50m
1 stop
GSP12:50 pmGreenville
$259
Delta
Aug 13
GSP5:46 amGreenville
3h 45m
1 stop
ECP8:31 amPanama City NW Florida Beaches
Aug 16
ECP6:00 amPanama City NW Florida Beaches
5h 41m
1 stop
GSP12:41 pmGreenville
$301
Delta
Jun 23
GSP11:44 amGreenville
5h 39m
1 stop
ECP4:23 pmPanama City NW Florida Beaches
Jun 30
ECP9:19 amPanama City NW Florida Beaches
4h 32m
1 stop
GSP2:51 pmGreenville
$303

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 3, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Thu 8/20

6:10 pm-11:38 pm

1 stop6h 28m

Panama City NW Florida Beaches

Mon 8/24

5:48 pm-10:38 pm

1 stop3h 50m

$257

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Fri 9/11

5:45 am-8:15 am

1 stop3h 30m

Panama City NW Florida Beaches

Tue 9/15

6:00 am-12:50 pm

1 stop5h 50m

$259

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Thu 8/13

5:46 am-8:31 am

1 stop3h 45m

Panama City NW Florida Beaches

Sun 8/16

6:00 am-12:41 pm

1 stop5h 41m

$301

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Tue 6/23

11:44 am-4:23 pm

1 stop5h 39m

Panama City NW Florida Beaches

Tue 6/30

9:19 am-2:51 pm

1 stop4h 32m

$303

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Sat 6/20

5:51 pm-11:07 pm

1 stop6h 16m

Panama City NW Florida Beaches

Thu 6/25

6:00 am-1:02 pm

1 stop6h 02m

$304

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Tue 6/30

6:06 pm-11:40 pm

1 stop6h 34m

Panama City NW Florida Beaches

Tue 7/7

4:17 pm-9:43 pm

1 stop4h 26m

$307

CharlottePanama City

CLT - ECP

CLTECP

Charlotte Douglas

Sat 8/29

8:25 am-1:55 pm

1 stop6h 30m

Panama City NW Florida Beaches

Mon 8/31

1:30 pm-6:40 pm

1 stop4h 10m

$308
Quickest round-trip

CharlestonPanama City

CHS - ECP

CHSECP

Charleston

Sat 9/19

4:15 pm-6:59 pm

1 stop3h 44m

Panama City NW Florida Beaches

Sat 9/26

7:35 am-1:25 pm

1 stop4h 50m

$309

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Wed 7/15

8:30 am-4:45 pm

2 stops9h 15m

Panama City NW Florida Beaches

Wed 7/22

2:25 pm-8:35 pm

1 stop5h 10m

$312

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Thu 7/2

6:25 am-1:24 pm

1 stop7h 59m

Panama City NW Florida Beaches

Wed 7/8

2:05 pm-9:16 pm

1 stop6h 11m

$753

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Carolina is in June. Flight prices, which tend to average around $77, are often lower during this time because this is during the off-season. The month of July is another great option to travel to Panama City, Florida, with average flight prices from South Carolina averaging around $124.

Cheap South Carolina to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City, Florida

Fastest flight time

1h 42m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The fastest flight from South Carolina to Panama City, Florida takes 1h 42m
Direct flights go from South Carolina to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From South Carolina there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from South Carolina to Panama City, Florida

  • When did momondo last update prices for flights from South Carolina to Panama City NW Florida Beaches Airport?

    Prices for flights from South Carolina to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Carolina to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Panama City, Florida

Compare and see reviews for airlines that fly from South Carolina to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $195Free CancellationRating
7.9
8,398 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

It is quick and easy to find South Carolina to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Panama City?

momondo helps you find the best flight between South Carolina and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South Carolina to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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