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Cheap flights from South Carolina to Panama City from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 5/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:06 pm - 11:40 pm
MYR
-
ECP
6h 34m
1 stop
American Airlines Logo
4:16 pm - 9:47 pm
ECP
-
MYR
4h 31m
1 stop
$275American Airlines
Wed, Jun 24 - Wed, Jul 1
Delta Logo
6:15 am - 8:30 am
CHS
-
ECP
3h 15m
1 stop
Delta Logo
6:00 am - 12:10 pm
ECP
-
CHS
5h 10m
1 stop
$287Delta
Wed, May 13 - Wed, May 20
Delta Logo
5:40 am - 8:30 am
GSP
-
ECP
3h 50m
1 stop
Delta Logo
6:00 am - 10:35 am
ECP
-
GSP
3h 35m
1 stop
$287Delta
Tue, May 19 - Wed, May 20
Southwest Logo
4:05 pm - 6:55 pm
MYR
-
ECP
3h 50m
1 stop
Southwest Logo
9:50 am - 4:10 pm
ECP
-
MYR
5h 20m
1 stop
$293Southwest
Tue, May 26 - Sat, May 30
Southwest Logo
7:35 am - 6:55 pm
MYR
-
ECP
12h 20m
2 stops
Southwest Logo
9:50 am - 4:10 pm
ECP
-
MYR
5h 20m
1 stop
$304Southwest
Tue, May 26 - Sat, May 30
American Airlines Logo
8:12 pm - 11:46 pm
CAE
-
ECP
4h 34m
1 stop
American Airlines Logo
7:21 am - 2:16 pm
ECP
-
CAE
5h 55m
1 stop
$309American Airlines
Sun, May 3 - Sat, May 9
Delta Logo
4:01 pm - 7:36 pm
CAE
-
ECP
4h 35m
1 stop
Delta Logo
6:00 am - 11:11 am
ECP
-
CAE
4h 11m
1 stop
$314Delta
Sun, May 3 - Sat, May 9
Delta Logo
10:09 am - 12:50 pm
GSP
-
ECP
3h 41m
1 stop
Delta Logo
6:00 am - 10:35 am
ECP
-
GSP
3h 35m
1 stop
$317Delta
Sun, May 17 - Wed, May 20
United Airlines Logo
6:30 am - 1:23 pm
CAE
-
ECP
7h 53m
1 stop
United Airlines Logo
2:14 pm - 11:59 pm
ECP
-
CAE
8h 45m
2 stops
$470United Airlines
Tue, Apr 28 - Sat, May 2
United Airlines Logo
6:30 am - 1:21 pm
CAE
-
ECP
7h 51m
1 stop
United Airlines Logo
10:30 am - 11:59 pm
ECP
-
CAE
12h 29m
2 stops
$526United Airlines
Sun, May 3 - Sat, May 9

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Delta flights from South Carolina to Panama City, Florida

Our best Delta deals on South Carolina to Panama City, Florida flight tickets
Delta
May 13
CHS6:15 amCharleston
3h 15m
1 stop
ECP8:30 amPanama City NW Florida Beaches
May 20
ECP6:00 amPanama City NW Florida Beaches
5h 10m
1 stop
CHS12:10 pmCharleston
$287
Delta
May 3
CAE4:01 pmColumbia Metropolitan
4h 35m
1 stop
ECP7:36 pmPanama City NW Florida Beaches
May 9
ECP6:00 amPanama City NW Florida Beaches
4h 11m
1 stop
CAE11:11 amColumbia Metropolitan
$314
Delta
May 17
GSP10:09 amGreenville
3h 41m
1 stop
ECP12:50 pmPanama City NW Florida Beaches
May 20
ECP6:00 amPanama City NW Florida Beaches
3h 35m
1 stop
GSP10:35 amGreenville
$317

United Airlines flights from South Carolina to Panama City, Florida

Our best United Airlines deals on South Carolina to Panama City, Florida flight tickets
United Airlines
May 12
GSP5:00 pmGreenville
6h 05m
1 stop
ECP10:05 pmPanama City NW Florida Beaches
May 13
ECP2:14 pmPanama City NW Florida Beaches
7h 44m
1 stop
GSP10:58 pmGreenville
$399
United Airlines
May 12
GSP5:00 pmGreenville
6h 05m
1 stop
ECP10:05 pmPanama City NW Florida Beaches
May 13
ECP2:14 pmPanama City NW Florida Beaches
7h 44m
1 stop
GSP10:58 pmGreenville
$408
United Airlines
Sep 19
GSP6:30 amGreenville
7h 28m
1 stop
ECP12:58 pmPanama City NW Florida Beaches
Sep 30
ECP10:25 amPanama City NW Florida Beaches
12h 04m
2 stops
GSP11:29 pmGreenville
$422

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 17, 2026.
Use the filters below to find and compare flights from South Carolina to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Wed 6/24

6:06 pm-11:40 pm

1 stop6h 34m

Panama City NW Florida Beaches

Wed 7/1

4:16 pm-9:47 pm

1 stop4h 31m

$275

CharlestonPanama City

CHS - ECP

CHSECP

Charleston

Wed 5/13

6:15 am-8:30 am

1 stop3h 15m

Panama City NW Florida Beaches

Wed 5/20

6:00 am-12:10 pm

1 stop5h 10m

$287

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Tue 5/19

5:40 am-8:30 am

1 stop3h 50m

Panama City NW Florida Beaches

Wed 5/20

6:00 am-10:35 am

1 stop3h 35m

$287

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Tue 5/26

4:05 pm-6:55 pm

1 stop3h 50m

Panama City NW Florida Beaches

Sat 5/30

9:50 am-4:10 pm

1 stop5h 20m

$293

Myrtle BeachPanama City

MYR - ECP

MYRECP

Myrtle Beach Intl

Tue 5/26

7:35 am-6:55 pm

2 stops12h 20m

Panama City NW Florida Beaches

Sat 5/30

9:50 am-4:10 pm

1 stop5h 20m

$304

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Sun 5/3

8:12 pm-11:46 pm

1 stop4h 34m

Panama City NW Florida Beaches

Sat 5/9

7:21 am-2:16 pm

1 stop5h 55m

$309

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Sun 5/3

4:01 pm-7:36 pm

1 stop4h 35m

Panama City NW Florida Beaches

Sat 5/9

6:00 am-11:11 am

1 stop4h 11m

$314
Quickest round-trip

GreenvillePanama City

GSP - ECP

GSPECP

Greenville

Sun 5/17

10:09 am-12:50 pm

1 stop3h 41m

Panama City NW Florida Beaches

Wed 5/20

6:00 am-10:35 am

1 stop3h 35m

$317

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Tue 4/28

6:30 am-1:23 pm

1 stop7h 53m

Panama City NW Florida Beaches

Sat 5/2

2:14 pm-11:59 pm

2 stops8h 45m

$470

ColumbiaPanama City

CAE - ECP

CAEECP

Columbia Metropolitan

Sun 5/3

6:30 am-1:21 pm

1 stop7h 51m

Panama City NW Florida Beaches

Sat 5/9

10:30 am-11:59 pm

2 stops12h 29m

$526

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Carolina is in August. Flight prices, which tend to average around $301, are often lower during this time because this is during the off-season. The month of November is another great option to travel to Panama City, Florida, with average flight prices from South Carolina averaging around $327.

Cheap South Carolina to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City, Florida

Fastest flight time

1h 43m

Direct flights

Every day

Airports in Panama City, Florida

1 airport
The fastest flight from South Carolina to Panama City, Florida takes 1h 43m
Direct flights go from South Carolina to Panama City, Florida every day.
There is 1 airport in Panama City, Florida. From South Carolina there are direct flights to Panama City NW Florida Beaches (ECP).
Search flight deals

Frequently asked questions about flying from South Carolina to Panama City, Florida

  • When did momondo last update prices for flights from South Carolina to Panama City NW Florida Beaches Airport?

    Prices for flights from South Carolina to Panama City NW Florida Beaches Airport refresh daily.

  • How many operators does momondo search for flights from South Carolina to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from South Carolina to Panama City NW Florida Beaches Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Panama City, Florida

Compare and see reviews for airlines that fly from South Carolina to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $207Free CancellationRating
7.9
8,409 reviews
Search Delta flights
American AirlinesPriceFrom $272Free CancellationRating
7.1
11,596 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

It is quick and easy to find South Carolina to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Panama City?

momondo helps you find the best flight between South Carolina and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South Carolina to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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