What is the cheapest airline that flies from South Carolina to Panama City NW Florida Beaches?

American Airlines, Southwest, and Delta are the most popular carriers operating from South Carolina to Panama City NW Florida Beaches

How long does it take to fly to Panama City, Florida?

Flight times vary depending on what airport in South Carolina you fly out of and what airport in Panama City, Florida you fly into. For example, flying from Greenville to Pensacola takes 3h 40m on average. On the other hand, flying from Columbia to Pensacola takes 3h 47m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

What airlines fly to Panama City, Florida?

Delta, American Airlines and Southwest are the top three most popular airlines that fly to Panama City, Florida from South Carolina according to our data. Delta is the first choice among our users, with 82% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 3 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from South Carolina to Panama City NW Florida Beaches Airport?

Prices for flights from South Carolina to Panama City NW Florida Beaches Airport refresh daily.

How many operators does momondo search for flights from South Carolina to Panama City NW Florida Beaches Airport?

There are 2 operators available for flights from South Carolina to Panama City NW Florida Beaches Airport as of October 2026.

How old do you have to be to fly from South Carolina to Panama City NW Florida Beaches Airport?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Panama City NW Florida Beaches Airport.

What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$209 Cheap Flights from South Carolina to Panama City, Florida in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from South Carolina to Panama City

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:58 pm - 11:24 pmMYR Myrtle Beach Intl-ECP Panama City NW Florida Beaches

5h 26m1 stop Atlanta Hartsfield-Jackson

6:00 am - 10:07 amECP Panama City NW Florida Beaches-MYR Myrtle Beach Intl

3h 07m1 stop Atlanta Hartsfield-Jackson

$257Delta

Tue, Nov 17 - Thu, Nov 19

5:40 am - 10:34 amGSP Greenville-ECP Panama City NW Florida Beaches

5h 54m1 stop Atlanta Hartsfield-Jackson

1:38 pm - 7:56 pmECP Panama City NW Florida Beaches-GSP Greenville

5h 18m1 stop Atlanta Hartsfield-Jackson

$279Delta

Sat, Dec 12 - Tue, Dec 15

5:40 am - 8:38 amGSP Greenville-ECP Panama City NW Florida Beaches

3h 58m1 stop Atlanta Hartsfield-Jackson

1:38 pm - 7:56 pmECP Panama City NW Florida Beaches-GSP Greenville

5h 18m1 stop Atlanta Hartsfield-Jackson

$279Delta

Tue, Dec 15 - Tue, Dec 15

8:06 am - 12:52 pmGSP Greenville-ECP Panama City NW Florida Beaches

5h 46m1 stop Atlanta Hartsfield-Jackson

1:38 pm - 7:56 pmECP Panama City NW Florida Beaches-GSP Greenville

5h 18m1 stop Atlanta Hartsfield-Jackson

$279Delta

Mon, Dec 14 - Tue, Dec 15

6:40 am - 9:30 amCHS Charleston-ECP Panama City NW Florida Beaches

3h 50m1 stop Nashville Intl

10:05 am - 7:35 pmECP Panama City NW Florida Beaches-CHS Charleston

8h 30m2 stops Austin Bergstrom Nashville Intl

$284Southwest

Sat, Dec 5 - Mon, Dec 7

6:40 am - 4:05 pmCHS Charleston-ECP Panama City NW Florida Beaches

10h 25m2 stops Nashville Intl Austin Bergstrom

10:05 am - 7:35 pmECP Panama City NW Florida Beaches-CHS Charleston

8h 30m2 stops Austin Bergstrom Nashville Intl

$289Southwest

Sat, Dec 5 - Mon, Dec 7

6:35 am - 9:30 amCHS Charleston-ECP Panama City NW Florida Beaches

3h 55m1 stop Nashville Intl

10:05 am - 7:35 pmECP Panama City NW Florida Beaches-CHS Charleston

8h 30m2 stops Austin Bergstrom Nashville Intl

$304Southwest

Fri, Dec 4 - Mon, Dec 7

2:28 pm - 6:32 pmGSP Greenville-ECP Panama City NW Florida Beaches

5h 04m1 stop Charlotte Douglas

5:59 pm - 10:42 pmECP Panama City NW Florida Beaches-GSP Greenville

3h 43m1 stop Charlotte Douglas

$309American Airlines

Thu, Dec 31 - Wed, Jan 6

5:00 am - 10:03 amMYR Myrtle Beach Intl-ECP Panama City NW Florida Beaches

6h 03m1 stop Charlotte Douglas

4:40 pm - 11:57 pmECP Panama City NW Florida Beaches-MYR Myrtle Beach Intl

6h 17m1 stop Charlotte Douglas

$397American Airlines

Sat, Apr 10 - Thu, Apr 15

12:45 pm - 6:32 pmCAE Columbia Metropolitan-ECP Panama City NW Florida Beaches

6h 47m1 stop Charlotte Douglas

5:59 pm - 10:43 pmECP Panama City NW Florida Beaches-CAE Columbia Metropolitan

3h 44m1 stop Charlotte Douglas

$417American Airlines

Thu, Dec 31 - Fri, Jan 8

Cheap last minute flights

Enter your travel dates to find the best prices.

8:30 pm - 11:53 pmCAE Columbia Metropolitan-ECP Panama City NW Florida Beaches

4h 23m1 stop Charlotte Douglas

7:01 pm - 11:53 pmECP Panama City NW Florida Beaches-CAE Columbia Metropolitan

3h 52m1 stop Charlotte Douglas

$635American Airlines

Thu, Oct 29 - Sun, Nov 1

2:33 pm - 6:42 pmCAE Columbia Metropolitan-ECP Panama City NW Florida Beaches

5h 09m1 stop Charlotte Douglas

7:10 am - 2:06 pmECP Panama City NW Florida Beaches-CAE Columbia Metropolitan

5h 56m1 stop Charlotte Douglas

$635American Airlines

Thu, Oct 29 - Sun, Nov 1

8:30 pm - 11:53 pmCAE Columbia Metropolitan-ECP Panama City NW Florida Beaches

4h 23m1 stop Charlotte Douglas

7:01 pm - 11:53 pmECP Panama City NW Florida Beaches-CAE Columbia Metropolitan

3h 52m1 stop Charlotte Douglas

$635American Airlines

Fri, Oct 30 - Sun, Nov 1

2:18 pm - 7:06 pmCHS Charleston-ECP Panama City NW Florida Beaches

5h 48m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:07 amECP Panama City NW Florida Beaches-CHS Charleston

4h 07m1 stop Atlanta Hartsfield-Jackson

$656Delta

Tue, Nov 3 - Thu, Nov 5

6:35 am - 3:35 pmCHS Charleston-ECP Panama City NW Florida Beaches

10h 00m2 stops Nashville Intl Austin Bergstrom

11:25 am - 6:30 pmECP Panama City NW Florida Beaches-CHS Charleston

6h 05m1 stop Nashville Intl

$696Southwest

Tue, Nov 3 - Thu, Nov 5

6:35 am - 3:35 pmCHS Charleston-ECP Panama City NW Florida Beaches

10h 00m2 stops Nashville Intl Austin Bergstrom

11:25 am - 10:20 pmECP Panama City NW Florida Beaches-CHS Charleston

9h 55m2 stops Nashville Intl Baltimore/Washington

$707Southwest

Tue, Nov 3 - Thu, Nov 5

5:00 pm - 7:06 pmGSP Greenville-ECP Panama City NW Florida Beaches

3h 06m1 stop Atlanta Hartsfield-Jackson

7:12 am - 12:39 pmECP Panama City NW Florida Beaches-GSP Greenville

4h 27m1 stop Atlanta Hartsfield-Jackson

$733Delta

Sat, Oct 31 - Tue, Nov 3

5:00 pm - 7:53 pmGSP Greenville-ECP Panama City NW Florida Beaches

3h 53m1 stop Atlanta Hartsfield-Jackson

6:55 pm - 10:56 pmECP Panama City NW Florida Beaches-GSP Greenville

3h 01m1 stop Atlanta Hartsfield-Jackson

$770Delta

Mon, Nov 2 - Mon, Nov 9

10:45 am - 6:42 pmCAE Columbia Metropolitan-ECP Panama City NW Florida Beaches

8h 57m2 stops Washington, D.C. Reagan-National Charlotte Douglas

7:10 am - 12:17 pmECP Panama City NW Florida Beaches-CAE Columbia Metropolitan

4h 07m1 stop Charlotte Douglas

$984American Airlines

Thu, Oct 29 - Sun, Nov 1

5:12 pm - 9:36 pmGSP Greenville-ECP Panama City NW Florida Beaches

5h 24m1 stop Houston George Bush Intcntl

4:55 pm - 9:51 amECP Panama City NW Florida Beaches-GSP Greenville

15h 56m2 stops Houston George Bush Intcntl Chicago O'Hare Intl

$1,076United Airlines

Mon, Nov 2 - Mon, Nov 9

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Delta flights from South Carolina to Panama City, Florida

Our best Delta deals on South Carolina to Panama City, Florida flight tickets

Delta

Nov 17

MYR6:58 pmMyrtle Beach Intl

5h 26m

1 stop

ECP11:24 pmPanama City NW Florida Beaches

Nov 19

ECP6:00 amPanama City NW Florida Beaches

3h 07m

1 stop

MYR10:07 amMyrtle Beach Intl

$257

Delta

Dec 12

GSP5:40 amGreenville

5h 54m

1 stop

ECP10:34 amPanama City NW Florida Beaches

Dec 15

ECP1:38 pmPanama City NW Florida Beaches

5h 18m

1 stop

GSP7:56 pmGreenville

$279

Delta

Nov 26

MYR4:00 pmMyrtle Beach Intl

6h 32m

1 stop

ECP9:32 pmPanama City NW Florida Beaches

Dec 3

ECP7:04 amPanama City NW Florida Beaches

5h 29m

1 stop

MYR1:33 pmMyrtle Beach Intl

$283

United Airlines flights from South Carolina to Panama City, Florida

Our best United Airlines deals on South Carolina to Panama City, Florida flight tickets

United Airlines

Dec 8

GSP6:30 amGreenville

7h 47m

1 stop

ECP1:17 pmPanama City NW Florida Beaches

Dec 9

ECP1:58 pmPanama City NW Florida Beaches

6h 01m

1 stop

GSP8:59 pmGreenville

$337

United Airlines

Dec 8

GSP5:00 pmGreenville

5h 38m

1 stop

ECP9:38 pmPanama City NW Florida Beaches

Dec 9

ECP1:30 pmPanama City NW Florida Beaches

7h 29m

1 stop

GSP9:59 pmGreenville

$347

United Airlines

Dec 8

GSP5:00 pmGreenville

5h 38m

1 stop

ECP9:38 pmPanama City NW Florida Beaches

Dec 9

ECP1:30 pmPanama City NW Florida Beaches

7h 29m

1 stop

GSP9:59 pmGreenville

$399

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Quickest round-trip

Myrtle BeachPanama City

MYR Myrtle Beach Intl - ECP Panama City NW Florida Beaches

MYRECP

Myrtle Beach Intl

Tue 11/17

6:58 pm-11:24 pm

1 stop5h 26m

Panama City NW Florida Beaches

Thu 11/19

6:00 am-10:07 am

1 stop3h 07m

$257

GreenvillePanama City

GSP Greenville - ECP Panama City NW Florida Beaches

GSPECP

Greenville

Sat 12/12

5:40 am-10:34 am

1 stop5h 54m

Panama City NW Florida Beaches

Tue 12/15

1:38 pm-7:56 pm

1 stop5h 18m

$279

GreenvillePanama City

GSP Greenville - ECP Panama City NW Florida Beaches

GSPECP

Greenville

Tue 12/15

5:40 am-8:38 am

1 stop3h 58m

Panama City NW Florida Beaches

Tue 12/15

1:38 pm-7:56 pm

1 stop5h 18m

$279

GreenvillePanama City

GSP Greenville - ECP Panama City NW Florida Beaches

GSPECP

Greenville

Mon 12/14

8:06 am-12:52 pm

1 stop5h 46m

Panama City NW Florida Beaches

Tue 12/15

1:38 pm-7:56 pm

1 stop5h 18m

$279

CharlestonPanama City

CHS Charleston - ECP Panama City NW Florida Beaches

CHSECP

Charleston

Sat 12/5

6:40 am-9:30 am

1 stop3h 50m

Panama City NW Florida Beaches

Mon 12/7

10:05 am-7:35 pm

2 stops8h 30m

$284

CharlestonPanama City

CHS Charleston - ECP Panama City NW Florida Beaches

CHSECP

Charleston

Sat 12/5

6:40 am-4:05 pm

2 stops10h 25m

Panama City NW Florida Beaches

Mon 12/7

10:05 am-7:35 pm

2 stops8h 30m

$289

CharlestonPanama City

CHS Charleston - ECP Panama City NW Florida Beaches

CHSECP

Charleston

Fri 12/4

6:35 am-9:30 am

1 stop3h 55m

Panama City NW Florida Beaches

Mon 12/7

10:05 am-7:35 pm

2 stops8h 30m

$304

GreenvillePanama City

GSP Greenville - ECP Panama City NW Florida Beaches

GSPECP

Greenville

Thu 12/31

2:28 pm-6:32 pm

1 stop5h 04m

Panama City NW Florida Beaches

Wed 1/6

5:59 pm-10:42 pm

1 stop3h 43m

$309

Myrtle BeachPanama City

MYR Myrtle Beach Intl - ECP Panama City NW Florida Beaches

MYRECP

Myrtle Beach Intl

Sat 4/10

5:00 am-10:03 am

1 stop6h 03m

Panama City NW Florida Beaches

Thu 4/15

4:40 pm-11:57 pm

1 stop6h 17m

$397

ColumbiaPanama City

CAE Columbia Metropolitan - ECP Panama City NW Florida Beaches

CAEECP

Columbia Metropolitan

Thu 12/31

12:45 pm-6:32 pm

1 stop6h 47m

Panama City NW Florida Beaches

Fri 1/8

5:59 pm-10:43 pm

1 stop3h 44m

$417

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from South Carolina to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from South Carolina is in February. Flight prices, which tend to average around $337, are often lower during this time because this is during the off-season. The month of January is another great option to travel to Panama City, Florida, with average flight prices from South Carolina averaging around $361.

Cheap South Carolina to Panama City, Florida flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Panama City, Florida

Best Price Found	$209
Fastest flight time	3h 04m
Direct flights	None

The best one-way flight to Panama City, Florida from South Carolina in the past 72 hours is $209. The best round-trip flight deal from South Carolina to Panama City, Florida found on momondo in the last 72 hours is $257.

The fastest flight from South Carolina to Panama City, Florida takes 3h 04m

There are no direct flights from South Carolina to Panama City, Florida. There are no popular flight routes from South Carolina to Panama City, Florida.

Search flight deals

Frequently asked questions about flying from South Carolina to Panama City, Florida

When did momondo last update prices for flights from South Carolina to Panama City NW Florida Beaches Airport?
Prices for flights from South Carolina to Panama City NW Florida Beaches Airport refresh daily.
How many operators does momondo search for flights from South Carolina to Panama City NW Florida Beaches Airport?
There are 2 operators available for flights from South Carolina to Panama City NW Florida Beaches Airport as of October 2026.
How old do you have to be to fly from South Carolina to Panama City NW Florida Beaches Airport?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Panama City NW Florida Beaches Airport.
What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?
The necessary travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

Best airlines flying from South Carolina to Panama City, Florida

Compare and see reviews for airlines that fly from South Carolina to Panama City, Florida with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $264	Free Cancellation	Rating 7.0 12,196 reviews		Search American Airlines flights
Delta	PriceFrom $272	Free Cancellation	Rating 7.8 8,681 reviews		Search Delta flights

Panama City Beach

Rosemary Beach

Port St. Joe

Seaside

Mexico Beach

Seagrove Beach

Freeport

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Panama City?

It is quick and easy to find South Carolina to Panama City flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Panama City that suits you.

Can I find flights from South Carolina to Panama City with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for South Carolina to Panama City flights to just show those with flexible booking policies.

How can momondo help me find flights from South Carolina to Panama City?

momondo helps you find the best flight between South Carolina and Panama City by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from South Carolina to Panama City right now. Can momondo alert me if prices change?

If you are not ready to book a flight from South Carolina to Panama City now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Panama City and let you know when they change.

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Cheap flights from South Carolina to Panama City from $209

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Panama City departing on 11/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Delta flights from South Carolina to Panama City, Florida

Our best Delta deals on South Carolina to Panama City, Florida flight tickets

United Airlines flights from South Carolina to Panama City, Florida

Our best United Airlines deals on South Carolina to Panama City, Florida flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from South Carolina to Panama City, Florida that are best for you.

See travel insights to Panama City from

How to get the cheapest flight ticket from South Carolina to Panama City, Florida

What is the cheapest month to fly to Panama City, Florida?

What is the cheapest airline that flies from South Carolina to Panama City NW Florida Beaches?

What airlines fly to Panama City, Florida?

How long does it take to fly to Panama City, Florida?

Cheap South Carolina to Panama City, Florida flight deals and tips

Best Price Found

Fastest flight time

Direct flights

Frequently asked questions about flying from South Carolina to Panama City, Florida

Best airlines flying from South Carolina to Panama City, Florida

Compare and see reviews for airlines that fly from South Carolina to Panama City, Florida with momondo

Traveling to a place near Panama City?

Why use momondo?

An easier way to manage your Panama City, Florida trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Florida

Fly your favorite airline to Panama City

Airlines are sorted and displayed according to clicks in the past 7 days on momondo

Cabin classes currently available on flights to Panama City

List of cabin classes available on flights landing in Panama City. Availability may vary depending on flight origin and airline.

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Popular flights according to clicks in the last 7 days on momondo

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