Cheap flights from South Carolina to Key West from $86

In general, September is the cheapest month to fly from South Carolina to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $65. If you are unable to visit Key West during the month of September, then departing from South Carolina during the month May is also very affordable. Most momondo users find prices during this month for around $77.

You are more likely to see cheaper flights to Key West from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $420 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from South Carolina for as low as $267 on momondo.

Breeze Airways, Allegiant Air, and Delta are the most popular carriers operating from South Carolina to Key West

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to Key West from South Carolina according to our data. American Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to Key West. Keep in mind that there are 4 different airlines that fly to Key West on a routine basis, so you have a few additional options to choose from.

As of June 2026, 20 flights take off from South Carolina and land in Key West each week. The most common flight departure day for this route is Mon, with 15% of weekly flights taking off on this day.

If you’re flying from a popular airport in South Carolina, such as Charleston or Columbia, and flying into Key West, then you can expect flight times to average 3h 24m and 3h 57m, respectively.