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Cheap flights from South Carolina to Key West from $95

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Key West departing on 1/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Key West

Cheap round-trip flights

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Breeze Airways Logo
8:59 pm - 9:09 amCHS-EYW
12h 10m1 stop
Breeze Airways Logo
9:46 am - 8:43 amEYW-CHS
22h 57m1 stop
$186Breeze Airways
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Thu, Feb 5 - Sun, Feb 8
Spirit Airlines Logo
5:45 am - 1:30 pmCLT-EYW
7h 45m1 stop
Spirit Airlines Logo
2:25 pm - 12:59 amEYW-CLT
10h 34m1 stop
$189Spirit Airlines
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Thu, Jan 22 - Tue, Jan 27
Breeze Airways Logo
2:59 pm - 8:15 amCHS-EYW
17h 16m1 stop
Breeze Airways Logo
10:47 am - 2:29 pmEYW-CHS
3h 42m1 stop
$191Breeze Airways
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Thu, Nov 27 - Sat, Dec 6
Multiple Airlines Logo
11:56 am - 2:51 pmCLT-EYW
26h 55m1 stop
Multiple Airlines Logo
3:54 pm - 3:27 pmEYW-CLT
23h 33m2 stops
$216Multiple Airlines
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Fri, Nov 28 - Fri, Dec 5
Multiple Airlines Logo
11:56 am - 2:51 pmCLT-EYW
26h 55m1 stop
Multiple Airlines Logo
9:57 am - 8:00 pmEYW-CLT
10h 03m1 stop
$220Multiple Airlines
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Fri, Nov 28 - Fri, Dec 5
American Airlines Logo
3:29 pm - 9:46 pmMYR-EYW
6h 17m1 stop
American Airlines Logo
8:00 am - 1:59 pmEYW-MYR
5h 59m1 stop
$249American Airlines
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Mon, Dec 8 - Sat, Dec 13
American Airlines Logo
6:23 am - 4:57 pmMYR-EYW
10h 34m2 stops
American Airlines Logo
4:53 pm - 10:05 pmEYW-MYR
5h 12m1 stop
$254American Airlines
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Mon, Dec 8 - Sat, Dec 13
Delta Logo
3:00 pm - 7:44 pmGSP-EYW
4h 44m1 stop
Delta Logo
7:00 am - 11:00 amEYW-GSP
4h 00m1 stop
$274Delta
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Tue, Feb 24 - Tue, Mar 3
Delta Logo
5:34 am - 11:43 amCAE-EYW
6h 09m1 stop
Delta Logo
3:02 pm - 6:57 pmEYW-CAE
3h 55m1 stop
$294Delta
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Wed, Dec 10 - Sat, Dec 13
Allegiant Air Logo
7:30 am - 8:46 pmSAV-EYW
13h 16m2 stops
Allegiant Air Logo
12:32 pm - 8:55 amEYW-SAV
20h 23m2 stops
$410Allegiant Air
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Thu, Nov 13 - Sun, Nov 16

Spirit Airlines flights from South Carolina to Key West

Our best Spirit Airlines deals on South Carolina to Key West flight tickets
Spirit Airlines
Jan 22
CLT5:45 amCharlotte Douglas
7h 45m
1 stop
EYW1:30 pmKey West
Jan 27
EYW2:25 pmKey West
10h 34m
1 stop
CLT12:59 amCharlotte Douglas
$189
Find similar
Spirit Airlines
Jan 8
CLT5:45 amCharlotte Douglas
7h 45m
1 stop
EYW1:30 pmKey West
Jan 11
EYW2:25 pmKey West
10h 34m
1 stop
CLT12:59 amCharlotte Douglas
$203
Find similar
Spirit Airlines
Jan 25
CLT5:45 amCharlotte Douglas
7h 45m
1 stop
EYW1:30 pmKey West
Jan 30
EYW2:25 pmKey West
6h 16m
1 stop
CLT8:41 pmCharlotte Douglas
$217
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American Airlines flights from South Carolina to Key West

Our best American Airlines deals on South Carolina to Key West flight tickets
American Airlines
Dec 8
MYR3:29 pmMyrtle Beach Intl
6h 17m
1 stop
EYW9:46 pmKey West
Dec 13
EYW8:00 amKey West
5h 59m
1 stop
MYR1:59 pmMyrtle Beach Intl
$249
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American Airlines
Dec 8
MYR6:23 amMyrtle Beach Intl
10h 34m
2 stops
EYW4:57 pmKey West
Dec 13
EYW4:53 pmKey West
5h 12m
1 stop
MYR10:05 pmMyrtle Beach Intl
$254
Find similar
American Airlines
Dec 5
MYR3:29 pmMyrtle Beach Intl
7h 38m
2 stops
EYW11:07 pmKey West
Dec 10
EYW7:00 amKey West
6h 29m
2 stops
MYR1:29 pmMyrtle Beach Intl
$259
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momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 2/5

8:59 pm-9:09 am

1 stop12h 10m

Key West

Sun 2/8

9:46 am-8:43 am

1 stop22h 57m

$186

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Thu 1/22

5:45 am-1:30 pm

1 stop7h 45m

Key West

Tue 1/27

2:25 pm-12:59 am

1 stop10h 34m

$189

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 11/27

2:59 pm-8:15 am

1 stop17h 16m

Key West

Sat 12/6

10:47 am-2:29 pm

1 stop3h 42m

$191

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Fri 11/28

11:56 am-2:51 pm

1 stop26h 55m

Key West

Fri 12/5

3:54 pm-3:27 pm

2 stops23h 33m

$216

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Fri 11/28

11:56 am-2:51 pm

1 stop26h 55m

Key West

Fri 12/5

9:57 am-8:00 pm

1 stop10h 03m

$220

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

3:29 pm-9:46 pm

1 stop6h 17m

Key West

Sat 12/13

8:00 am-1:59 pm

1 stop5h 59m

$249

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Mon 12/8

6:23 am-4:57 pm

2 stops10h 34m

Key West

Sat 12/13

4:53 pm-10:05 pm

1 stop5h 12m

$254

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Tue 2/24

3:00 pm-7:44 pm

1 stop4h 44m

Key West

Tue 3/3

7:00 am-11:00 am

1 stop4h 00m

$274

ColumbiaKey West

CAE - EYW

CAEEYW

Columbia Metropolitan

Wed 12/10

5:34 am-11:43 am

1 stop6h 09m

Key West

Sat 12/13

3:02 pm-6:57 pm

1 stop3h 55m

$294

SavannahKey West

SAV - EYW

SAVEYW

Savannah/Hilton Head

Thu 11/13

7:30 am-8:46 pm

2 stops13h 16m

Key West

Sun 11/16

12:32 pm-8:55 am

2 stops20h 23m

$410

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from South Carolina to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from South Carolina to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $336. If you are unable to visit Key West during the month of September, then departing from South Carolina during the month August is also very affordable. Most momondo users find prices during this month for around $356.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from South Carolina is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $496. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Key West for around $646.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is in the afternoon. momondo users have found flights departing from South Carolina to Key West in the afternoon for as low as $534. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly at noon, with an average ticket price of $617. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $503 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from South Carolina for as low as $338 on momondo.

Can stopping save me money on South Carolina to Key West flights?

You could potentially save up to 54% on your flight if you consider stops on a South Carolina to Key West flight.

Cheap South Carolina to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Key West

Fastest flight time

2h 08m

Direct flights

Every day

Airports in Key West

1 airport
The fastest flight from South Carolina to Key West takes 2h 08m
Direct flights go from South Carolina to Key West every day.
There is 1 airport near Key West: Key West (EYW)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Key West Airport?

    Prices for flights from South Carolina to Key West Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Key West Airport?

  • How old do you have to be to fly from South Carolina to Key West Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The required travel and health documents for your Key West Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Key West Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Key West

Compare and see reviews for airlines that fly from South Carolina to Key West with momondo
Airline
Rating
Free Cancellation
Price
Breeze AirwaysPriceFrom $110Free CancellationRating
8.1
221 reviews
Search Breeze Airways flights
DeltaPriceFrom $223Free CancellationRating
7.9
7,993 reviews
Search Delta flights
American AirlinesPriceFrom $253Free CancellationRating
7.2
11,030 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Key West?

It is quick and easy to find South Carolina to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from South Carolina to Key West with flexible booking policies on momondo?

Yes. All flights to Key West from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from South Carolina.

I’m not ready to book a flight from South Carolina to Key West right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Key West, momondo offers a useful price alert feature which will track prices for flights to Key West from South Carolina and alert you when they change.

An easier way to manage your Key West trip

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