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Cheap flights from South Carolina to Key West from $112

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Key West departing on 11/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from South Carolina to Key West

Cheap round-trip flights

Logo
3:34 pm - 4:00 pmCLT-EYW
24h 26m1 stop
Logo
9:52 am - 8:15 pmEYW-CLT
10h 23m1 stop
$184
Find Deal
Sat, Sep 13 - Sat, Sep 20
Logo
3:34 pm - 4:04 pmCLT-EYW
24h 30m1 stop
Logo
4:54 pm - 12:30 pmEYW-CLT
19h 36m1 stop
$194
Find Deal
Sat, Oct 4 - Thu, Oct 9
Spirit Airlines Logo
5:45 am - 1:30 pmCLT-EYW
7h 45m1 stop
Spirit Airlines Logo
2:25 pm - 8:41 pmEYW-CLT
6h 16m1 stop
$243Spirit Airlines
Find Deal
Wed, Jan 21 - Tue, Jan 27
Delta Logo
2:33 pm - 8:07 pmGSP-EYW
5h 34m1 stop
Delta Logo
7:00 am - 1:28 pmEYW-GSP
6h 28m1 stop
$249Delta
Find Deal
Tue, Sep 16 - Tue, Sep 23
Delta Logo
1:15 pm - 8:06 pmCAE-EYW
6h 51m1 stop
Delta Logo
7:40 am - 2:18 pmEYW-CAE
6h 38m1 stop
$249Delta
Find Deal
Sat, Oct 25 - Wed, Oct 29
American Airlines Logo
6:15 am - 11:13 amMYR-EYW
4h 58m1 stop
American Airlines Logo
12:00 pm - 6:46 pmEYW-MYR
6h 46m1 stop
$249American Airlines
Find Deal
Wed, Sep 17 - Wed, Sep 24
American Airlines Logo
6:02 am - 11:13 amGSP-EYW
5h 11m1 stop
American Airlines Logo
11:25 am - 10:58 pmEYW-GSP
11h 33m2 stops
$254American Airlines
Find Deal
Tue, Sep 16 - Tue, Sep 23
Spirit Airlines Logo
9:49 am - 1:30 pmCLT-EYW
3h 41m1 stop
Spirit Airlines Logo
2:25 pm - 12:59 amEYW-CLT
10h 34m1 stop
$263Spirit Airlines
Find Deal
Thu, Nov 13 - Sun, Nov 16
Breeze Airways Logo
4:33 pm - 9:22 amGSP-EYW
16h 49m1 stop
Breeze Airways Logo
8:47 am - 6:46 pmEYW-GSP
9h 59m1 stop
$300Breeze Airways
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Sun, Aug 31 - Fri, Sep 5
Breeze Airways Logo
8:53 pm - 8:07 amCHS-EYW
11h 14m1 stop
Breeze Airways Logo
8:47 am - 8:37 amEYW-CHS
23h 50m1 stop
$433Breeze Airways
Find Deal
Thu, Oct 2 - Mon, Oct 6

Spirit Airlines flights from South Carolina to Key West

Our best Spirit Airlines deals on South Carolina to Key West flight tickets
Spirit Airlines
Jan 21
CLT5:45 amCharlotte Douglas
7h 45m
1 stop
EYW1:30 pmKey West
Jan 27
EYW2:25 pmKey West
6h 16m
1 stop
CLT8:41 pmCharlotte Douglas
$243
Find similar
Spirit Airlines
Nov 13
CLT9:49 amCharlotte Douglas
3h 41m
1 stop
EYW1:30 pmKey West
Nov 16
EYW2:25 pmKey West
10h 34m
1 stop
CLT12:59 amCharlotte Douglas
$263
Find similar
Spirit Airlines
Nov 17
CLT9:49 amCharlotte Douglas
3h 41m
1 stop
EYW1:30 pmKey West
Nov 20
EYW2:25 pmKey West
10h 34m
1 stop
CLT12:59 amCharlotte Douglas
$282
Find similar

Delta flights from South Carolina to Key West

Our best Delta deals on South Carolina to Key West flight tickets
Delta
Sep 16
GSP2:33 pmGreenville
5h 34m
1 stop
EYW8:07 pmKey West
Sep 23
EYW7:00 amKey West
6h 28m
1 stop
GSP1:28 pmGreenville
$249
Find similar
Delta
Sep 16
CHS2:50 pmCharleston
5h 17m
1 stop
EYW8:07 pmKey West
Sep 23
EYW7:00 amKey West
6h 45m
1 stop
CHS1:45 pmCharleston
$287
Find similar
Delta
Oct 8
CHS4:14 pmCharleston
3h 52m
1 stop
EYW8:06 pmKey West
Oct 15
EYW7:40 amKey West
5h 45m
1 stop
CHS1:25 pmCharleston
$313
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 18, 2025.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sat 9/13

3:34 pm-4:00 pm

1 stop24h 26m

Key West

Sat 9/20

9:52 am-8:15 pm

1 stop10h 23m

$184

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sat 10/4

3:34 pm-4:04 pm

1 stop24h 30m

Key West

Thu 10/9

4:54 pm-12:30 pm

1 stop19h 36m

$194

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Wed 1/21

5:45 am-1:30 pm

1 stop7h 45m

Key West

Tue 1/27

2:25 pm-8:41 pm

1 stop6h 16m

$243

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Tue 9/16

2:33 pm-8:07 pm

1 stop5h 34m

Key West

Tue 9/23

7:00 am-1:28 pm

1 stop6h 28m

$249

ColumbiaKey West

CAE - EYW

CAEEYW

Columbia Metropolitan

Sat 10/25

1:15 pm-8:06 pm

1 stop6h 51m

Key West

Wed 10/29

7:40 am-2:18 pm

1 stop6h 38m

$249

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Wed 9/17

6:15 am-11:13 am

1 stop4h 58m

Key West

Wed 9/24

12:00 pm-6:46 pm

1 stop6h 46m

$249

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Tue 9/16

6:02 am-11:13 am

1 stop5h 11m

Key West

Tue 9/23

11:25 am-10:58 pm

2 stops11h 33m

$254

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Thu 11/13

9:49 am-1:30 pm

1 stop3h 41m

Key West

Sun 11/16

2:25 pm-12:59 am

1 stop10h 34m

$263

GreenvilleKey West

GSP - EYW

GSPEYW

Greenville

Sun 8/31

4:33 pm-9:22 am

1 stop16h 49m

Key West

Fri 9/5

8:47 am-6:46 pm

1 stop9h 59m

$300

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 10/2

8:53 pm-8:07 am

1 stop11h 14m

Key West

Mon 10/6

8:47 am-8:37 am

1 stop23h 50m

$433

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from South Carolina to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from South Carolina to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $347. If you are unable to visit Key West during the month of September, then departing from South Carolina during the month July is also very affordable. Most momondo users find prices during this month for around $426.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from South Carolina is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $496. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Key West for around $646.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is in the afternoon. momondo users have found flights departing from South Carolina to Key West in the afternoon for as low as $534. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly at noon, with an average ticket price of $617. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $518 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from South Carolina for as low as $375 on momondo.

Cheap South Carolina to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Key West

Best Price Found

$112

Fastest flight time

2h 20m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in Key West

1 airport
The best one-way flight to Key West from South Carolina in the past 72 hours is $112. The best round-trip flight deal from South Carolina to Key West found on momondo in the last 72 hours is $184.
The fastest flight from South Carolina to Key West takes 2h 20m
Direct flights go from South Carolina to Key West on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is American Airlines.
There is 1 airport near Key West: Key West (EYW)
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Key West Airport?

    Prices for flights from South Carolina to Key West Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Key West Airport?

  • How old do you have to be to fly from South Carolina to Key West Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The required travel and health documents for your Key West Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Key West Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Key West

Compare and see reviews for airlines that fly from South Carolina to Key West with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
8.0
7,981 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Key West?

It is quick and easy to find South Carolina to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from South Carolina to Key West with flexible booking policies on momondo?

Yes. All flights to Key West from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from South Carolina.

I’m not ready to book a flight from South Carolina to Key West right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Key West, momondo offers a useful price alert feature which will track prices for flights to Key West from South Carolina and alert you when they change.

An easier way to manage your Key West trip

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