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Cheap flights from South Carolina to Key West from $70

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from South Carolina to Key West departing on 12/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from South Carolina to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
Breeze Airways Logo
9:09 pm - 10:19 am
CHS
-
EYW
13h 10m1 stop
Breeze Airways Logo
1:10 pm - 8:37 am
EYW
-
CHS
19h 27m1 stop
$143Breeze Airways
Wed, Dec 31 - Mon, Jan 5
Breeze Airways Logo
2:59 pm - 12:30 pm
CHS
-
EYW
21h 31m1 stop
Breeze Airways Logo
1:10 pm - 8:37 am
EYW
-
CHS
19h 27m1 stop
$147Breeze Airways
Thu, Jan 1 - Mon, Jan 5
Spirit Airlines Logo
6:00 am - 11:56 am
CLT
-
EYW
5h 56m1 stop
Spirit Airlines Logo
12:51 pm - 6:48 pm
EYW
-
CLT
5h 57m1 stop
$169Spirit Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
9:59 pm - 12:26 pm
CLT
-
EYW
14h 27m1 stop
Multiple Airlines Logo
10:06 am - 5:59 pm
EYW
-
CLT
7h 53m1 stop
$174Multiple Airlines
Sun, Jan 25 - Thu, Jan 29
Multiple Airlines Logo
9:59 pm - 9:26 am
CLT
-
EYW
11h 27m1 stop
Multiple Airlines Logo
10:06 am - 5:59 pm
EYW
-
CLT
7h 53m1 stop
$186Multiple Airlines
Sat, Jan 24 - Thu, Jan 29
Spirit Airlines Logo
6:00 am - 1:30 pm
CLT
-
EYW
7h 30m1 stop
Spirit Airlines Logo
2:25 pm - 6:48 pm
EYW
-
CLT
4h 23m1 stop
$192Spirit Airlines
Fri, Jan 16 - Fri, Jan 23
American Airlines Logo
5:29 pm - 9:47 pm
MYR
-
EYW
4h 18m1 stop
American Airlines Logo
7:08 am - 1:23 pm
EYW
-
MYR
6h 15m1 stop
$209American Airlines
Thu, Jan 8 - Mon, Jan 12
American Airlines Logo
1:53 pm - 11:56 pm
MYR
-
EYW
10h 03m2 stops
American Airlines Logo
7:08 am - 11:35 am
EYW
-
MYR
4h 27m1 stop
$214American Airlines
Thu, Jan 8 - Mon, Jan 12
Delta Logo
5:35 am - 10:59 am
CAE
-
EYW
5h 24m1 stop
Delta Logo
2:46 pm - 6:25 pm
EYW
-
CAE
3h 39m1 stop
$354Delta
Tue, Feb 17 - Tue, Feb 24
Delta Logo
5:35 am - 10:59 am
CAE
-
EYW
5h 24m1 stop
Delta Logo
6:07 pm - 8:27 pm
EYW
-
CAE
26h 20m1 stop
$368Delta
Tue, Feb 17 - Fri, Feb 20

Breeze Airways flights from South Carolina to Key West

Our best Breeze Airways deals on South Carolina to Key West flight tickets
Breeze Airways
Dec 31
CHS9:09 pmCharleston
13h 10m
1 stop
EYW10:19 amKey West
Jan 5
EYW1:10 pmKey West
19h 27m
1 stop
CHS8:37 amCharleston
$143
Find similar
Breeze Airways
Jan 1
CHS2:59 pmCharleston
21h 31m
1 stop
EYW12:30 pmKey West
Jan 5
EYW1:10 pmKey West
19h 27m
1 stop
CHS8:37 amCharleston
$147
Find similar
Breeze Airways
Jan 1
CHS8:53 pmCharleston
12h 24m
1 stop
EYW9:17 amKey West
Jan 5
EYW1:10 pmKey West
19h 27m
1 stop
CHS8:37 amCharleston
$158
Find similar

Spirit Airlines flights from South Carolina to Key West

Our best Spirit Airlines deals on South Carolina to Key West flight tickets
Spirit Airlines
Jan 22
CLT6:00 amCharlotte Douglas
5h 56m
1 stop
EYW11:56 amKey West
Jan 29
EYW12:51 pmKey West
5h 57m
1 stop
CLT6:48 pmCharlotte Douglas
$169
Find similar
Spirit Airlines
Jan 16
CLT6:00 amCharlotte Douglas
7h 30m
1 stop
EYW1:30 pmKey West
Jan 23
EYW2:25 pmKey West
4h 23m
1 stop
CLT6:48 pmCharlotte Douglas
$192
Find similar
Spirit Airlines
Jan 15
CLT6:00 amCharlotte Douglas
5h 56m
1 stop
EYW11:56 amKey West
Jan 18
EYW12:51 pmKey West
5h 57m
1 stop
CLT6:48 pmCharlotte Douglas
$212
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from South Carolina to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from South Carolina to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Wed 12/31

9:09 pm-10:19 am

1 stop13h 10m

Key West

Mon 1/5

1:10 pm-8:37 am

1 stop19h 27m

$143

CharlestonKey West

CHS - EYW

CHSEYW

Charleston

Thu 1/1

2:59 pm-12:30 pm

1 stop21h 31m

Key West

Mon 1/5

1:10 pm-8:37 am

1 stop19h 27m

$147

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Thu 1/22

6:00 am-11:56 am

1 stop5h 56m

Key West

Thu 1/29

12:51 pm-6:48 pm

1 stop5h 57m

$169

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sun 1/25

9:59 pm-12:26 pm

1 stop14h 27m

Key West

Thu 1/29

10:06 am-5:59 pm

1 stop7h 53m

$174

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Sat 1/24

9:59 pm-9:26 am

1 stop11h 27m

Key West

Thu 1/29

10:06 am-5:59 pm

1 stop7h 53m

$186

CharlotteKey West

CLT - EYW

CLTEYW

Charlotte Douglas

Fri 1/16

6:00 am-1:30 pm

1 stop7h 30m

Key West

Fri 1/23

2:25 pm-6:48 pm

1 stop4h 23m

$192

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Thu 1/8

5:29 pm-9:47 pm

1 stop4h 18m

Key West

Mon 1/12

7:08 am-1:23 pm

1 stop6h 15m

$209

Myrtle BeachKey West

MYR - EYW

MYREYW

Myrtle Beach Intl

Thu 1/8

1:53 pm-11:56 pm

2 stops10h 03m

Key West

Mon 1/12

7:08 am-11:35 am

1 stop4h 27m

$214

ColumbiaKey West

CAE - EYW

CAEEYW

Columbia Metropolitan

Tue 2/17

5:35 am-10:59 am

1 stop5h 24m

Key West

Tue 2/24

2:46 pm-6:25 pm

1 stop3h 39m

$354

ColumbiaKey West

CAE - EYW

CAEEYW

Columbia Metropolitan

Tue 2/17

5:35 am-10:59 am

1 stop5h 24m

Key West

Fri 2/20

6:07 pm-8:27 pm

1 stop26h 20m

$368

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from South Carolina to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Key West?

In general, September is the cheapest month to fly from South Carolina to Key West. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $336. If you are unable to visit Key West during the month of September, then departing from South Carolina during the month August is also very affordable. Most momondo users find prices during this month for around $356.

What is the cheapest day to depart on your flight to Key West?

On average, the least expensive day to fly to Key West from South Carolina is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $496. However, this price may fluctuate depending on the airline, the season, and holidays. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from South Carolina to Key West for around $646.

What is the cheapest time of day to depart on your flight to Key West?

According to our data, the cheapest time of day to fly to Key West is in the afternoon. momondo users have found flights departing from South Carolina to Key West in the afternoon for as low as $534. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Flights to Key West are more costly at noon, with an average ticket price of $617. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

How far in advance should I book a flight to Key West?

You are more likely to see cheaper flights to Key West from South Carolina when booking weeks ahead of your departure date. In general, you can expect to find flights to Key West for around $480 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Key West from South Carolina for as low as $338 on momondo.

Can stopping save me money on South Carolina to Key West flights?

You could potentially save up to 27% on your flight if you consider stops on a South Carolina to Key West flight.

Cheap South Carolina to Key West flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from South Carolina to Key West

Fastest flight time

2h 17m

Direct flights

Every day

Airports in Key West

1 airport
The fastest flight from South Carolina to Key West takes 2h 17m
Direct flights go from South Carolina to Key West every day.
There is 1 airport in Key West. From South Carolina there are direct flights to Key West (EYW).
Search flight deals

  • When did momondo last update prices for flights from South Carolina to Key West Airport?

    Prices for flights from South Carolina to Key West Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from South Carolina to Key West Airport?

  • How old do you have to be to fly from South Carolina to Key West Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from South Carolina to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The required travel and health documents for your Key West Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Key West Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Best airlines flying from South Carolina to Key West

Compare and see reviews for airlines that fly from South Carolina to Key West with momondo
Airline
Rating
Free Cancellation
Price
Breeze AirwaysPriceFrom $110Free CancellationRating
8.2
248 reviews
Search Breeze Airways flights
DeltaPriceFrom $223Free CancellationRating
7.9
8,008 reviews
Search Delta flights
American AirlinesPriceFrom $253Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from South Carolina to Key West?

It is quick and easy to find South Carolina to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from South Carolina to Key West with flexible booking policies on momondo?

Yes. All flights to Key West from South Carolina on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from South Carolina to Key West?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Key West from South Carolina.

I’m not ready to book a flight from South Carolina to Key West right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Key West, momondo offers a useful price alert feature which will track prices for flights to Key West from South Carolina and alert you when they change.

An easier way to manage your Key West trip

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