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Cheap flights from Sioux Falls to Panama City from $301

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Panama City departing on 9/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Sioux Falls to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 11:42 amFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
5h 42m1 stop Dallas/Fort Worth
American Airlines Logo
3:17 pm - 8:45 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
5h 28m1 stop Dallas/Fort Worth
$301American Airlines
Tue, Sep 22 - Sat, Sep 26
United Airlines Logo
6:00 am - 2:31 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
8h 31m1 stop Denver Intl
United Airlines Logo
11:30 am - 9:37 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
10h 07m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
$306United Airlines
Sat, Oct 24 - Wed, Oct 28
American Airlines Logo
7:00 am - 5:32 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
10h 32m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
3:17 pm - 8:45 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
5h 28m1 stop Dallas/Fort Worth
$306American Airlines
Tue, Sep 22 - Sat, Sep 26
American Airlines Logo
2:48 pm - 11:53 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
9h 05m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
7:15 am - 7:51 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
12h 36m2 stops Charlotte Douglas Dallas/Fort Worth
$311American Airlines
Sat, Oct 24 - Wed, Oct 28
American Airlines Logo
6:00 am - 5:32 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
11h 32m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
3:17 pm - 8:45 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
5h 28m1 stop Dallas/Fort Worth
$320American Airlines
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:00 pm - 11:18 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
10h 18m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson
Delta Logo
9:22 am - 7:10 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
9h 48m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul
$381Delta
Fri, Nov 6 - Tue, Nov 10
Delta Logo
1:26 pm - 11:30 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
10h 04m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson
Delta Logo
1:46 pm - 10:51 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
9h 05m2 stops Atlanta Hartsfield-Jackson Minneapolis St Paul
$494Delta
Fri, Sep 4 - Thu, Sep 10
United Airlines Logo
7:50 am - 1:02 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
5h 12m1 stop Chicago O'Hare Intl
United Airlines Logo
11:41 am - 8:20 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
8h 39m2 stops Houston George Bush Intcntl Denver Intl
$504United Airlines
Sat, Oct 10 - Fri, Oct 16
Delta Logo
1:26 pm - 11:30 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
10h 04m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson
Delta Logo
1:46 pm - 7:47 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
6h 01m1 stop Atlanta Hartsfield-Jackson
$514Delta
Fri, Sep 4 - Thu, Sep 10
United Airlines Logo
7:40 am - 8:06 pmFSD  Sioux Falls Joe Foss Field-ECP Panama City NW Florida Beaches
12h 26m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
United Airlines Logo
6:30 am - 10:56 pmECP  Panama City NW Florida Beaches-FSD Sioux Falls Joe Foss Field
16h 26m2 stops Houston George Bush Intcntl Denver Intl
$552United Airlines
Wed, Jan 6 - Sat, Jan 9

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American Airlines flights from Sioux Falls to Panama City, Florida

Our best American Airlines deals on Sioux Falls to Panama City, Florida flight tickets
American Airlines
Sep 22
FSD6:00 amSioux Falls Joe Foss Field
5h 42m
1 stop
ECP11:42 amPanama City NW Florida Beaches
Sep 26
ECP3:17 pmPanama City NW Florida Beaches
5h 28m
1 stop
FSD8:45 pmSioux Falls Joe Foss Field
$301
American Airlines
Sep 22
FSD7:00 amSioux Falls Joe Foss Field
10h 32m
2 stops
ECP5:32 pmPanama City NW Florida Beaches
Sep 26
ECP3:17 pmPanama City NW Florida Beaches
5h 28m
1 stop
FSD8:45 pmSioux Falls Joe Foss Field
$306
American Airlines
Oct 24
FSD2:48 pmSioux Falls Joe Foss Field
9h 05m
2 stops
ECP11:53 pmPanama City NW Florida Beaches
Oct 28
ECP7:15 amPanama City NW Florida Beaches
12h 36m
2 stops
FSD7:51 pmSioux Falls Joe Foss Field
$311

United Airlines flights from Sioux Falls to Panama City, Florida

Our best United Airlines deals on Sioux Falls to Panama City, Florida flight tickets
United Airlines
Oct 10
FSD7:50 amSioux Falls Joe Foss Field
5h 12m
1 stop
ECP1:02 pmPanama City NW Florida Beaches
Oct 16
ECP11:41 amPanama City NW Florida Beaches
8h 39m
2 stops
FSD8:20 pmSioux Falls Joe Foss Field
$504
United Airlines
Jan 6
FSD7:40 amSioux Falls Joe Foss Field
12h 26m
2 stops
ECP8:06 pmPanama City NW Florida Beaches
Jan 9
ECP6:30 amPanama City NW Florida Beaches
16h 26m
2 stops
FSD10:56 pmSioux Falls Joe Foss Field
$552
United Airlines
Sep 4
FSD6:50 pmSioux Falls Joe Foss Field
19h 02m
2 stops
ECP1:52 pmPanama City NW Florida Beaches
Sep 10
ECP11:41 amPanama City NW Florida Beaches
11h 31m
2 stops
FSD11:12 pmSioux Falls Joe Foss Field
$557

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 7, 2026.
Use the filters below to find and compare flights from Sioux Falls to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

6:00 am-11:42 am

1 stop5h 42m

Panama City NW Florida Beaches

Sat 9/26

3:17 pm-8:45 pm

1 stop5h 28m

$301

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Sat 10/24

6:00 am-2:31 pm

1 stop8h 31m

Panama City NW Florida Beaches

Wed 10/28

11:30 am-9:37 pm

2 stops10h 07m

$306

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

7:00 am-5:32 pm

2 stops10h 32m

Panama City NW Florida Beaches

Sat 9/26

3:17 pm-8:45 pm

1 stop5h 28m

$306

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Sat 10/24

2:48 pm-11:53 pm

2 stops9h 05m

Panama City NW Florida Beaches

Wed 10/28

7:15 am-7:51 pm

2 stops12h 36m

$311

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

6:00 am-5:32 pm

2 stops11h 32m

Panama City NW Florida Beaches

Sat 9/26

3:17 pm-8:45 pm

1 stop5h 28m

$320

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Fri 11/6

1:00 pm-11:18 pm

2 stops10h 18m

Panama City NW Florida Beaches

Tue 11/10

9:22 am-7:10 pm

2 stops9h 48m

$381

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Fri 9/4

1:26 pm-11:30 pm

2 stops10h 04m

Panama City NW Florida Beaches

Thu 9/10

1:46 pm-10:51 pm

2 stops9h 05m

$494

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Sat 10/10

7:50 am-1:02 pm

1 stop5h 12m

Panama City NW Florida Beaches

Fri 10/16

11:41 am-8:20 pm

2 stops8h 39m

$504

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Fri 9/4

1:26 pm-11:30 pm

2 stops10h 04m

Panama City NW Florida Beaches

Thu 9/10

1:46 pm-7:47 pm

1 stop6h 01m

$514

Sioux FallsPanama City

FSD Sioux Falls Joe Foss Field - ECP Panama City NW Florida Beaches

FSDECP

Sioux Falls Joe Foss Field

Wed 1/6

7:40 am-8:06 pm

2 stops12h 26m

Panama City NW Florida Beaches

Sat 1/9

6:30 am-10:56 pm

2 stops16h 26m

$552

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Sioux Falls to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Sioux Falls to Panama City, Florida flights?

You could potentially save up to 3% on your flight if you consider stops on a Sioux Falls to Panama City, Florida flight.

When to book flights from Sioux Falls to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Panama City, Florida (FSD to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Panama City, Florida

Fastest flight time

5h 20m

Direct flights

None
The fastest flight from Sioux Falls to Panama City, Florida takes 5h 20m
There are no direct flights from Sioux Falls to Panama City, Florida. There are no popular flight routes from Sioux Falls to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Sioux Falls to Panama City, Florida

  • How far is Sioux Falls Joe Foss Field to Panama City NW Florida Beaches by plane?

    The straight-line distance from Sioux Falls Joe Foss Field to Panama City NW Florida Beaches is 1106.0 mi. In terms of flight time, this usually takes a little over 5h 20m.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport are updated daily.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Sioux Falls to Panama City, Florida?

Best airlines flying from Sioux Falls to Panama City, Florida

Compare and see reviews for airlines that fly from Sioux Falls to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $279Free CancellationRating
7.1
11,875 reviews
Search American Airlines flights
DeltaPriceFrom $310Free CancellationRating
7.8
8,499 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Panama City?

Finding the right flight to Panama City from Sioux Falls is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Sioux Falls to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Sioux Falls which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Sioux Falls to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Sioux Falls to Panama City.

I’m not ready to book a flight from Sioux Falls to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Sioux Falls and alert you when they change.

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