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Cheap flights from Sioux Falls to Panama City from $259

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Panama City departing on 12/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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American Airlines Logo
1:09 pm - 7:11 pmFSD-ECP
6h 02m1 stop
American Airlines Logo
6:30 am - 12:23 pmECP-FSD
5h 53m1 stop
$259American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
2:02 pm - 12:04 amFSD-ECP
10h 02m2 stops
American Airlines Logo
6:30 am - 12:23 pmECP-FSD
5h 53m1 stop
$264American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
11:37 am - 12:04 amFSD-ECP
12h 27m2 stops
American Airlines Logo
12:08 pm - 10:29 pmECP-FSD
10h 21m2 stops
$269American Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
American Airlines Logo
6:30 am - 12:39 pmFSD-ECP
6h 09m1 stop
American Airlines Logo
6:30 am - 12:23 pmECP-FSD
5h 53m1 stop
$324American Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
United Airlines Logo
8:00 am - 9:49 pmFSD-ECP
13h 49m3 stops
United Airlines Logo
3:00 pm - 11:43 pmECP-FSD
8h 43m2 stops
$354United Airlines
Find Deal
Sat, Dec 6 - Tue, Dec 9
Delta Logo
5:08 am - 11:20 amFSD-ECP
6h 12m1 stop
Delta Logo
6:03 pm - 11:12 pmECP-FSD
5h 09m1 stop
$599Delta
Find Deal
Mon, Mar 2 - Mon, Mar 2
Delta Logo
5:00 am - 1:27 pmFSD-ECP
8h 27m2 stops
Delta Logo
6:03 pm - 11:12 pmECP-FSD
5h 09m1 stop
$682Delta
Find Deal
Mon, Mar 2 - Mon, Mar 2
United Airlines Logo
11:20 am - 9:49 pmFSD-ECP
10h 29m3 stops
United Airlines Logo
3:00 pm - 11:43 pmECP-FSD
8h 43m2 stops
$750United Airlines
Find Deal
Wed, Dec 3 - Wed, Dec 10
United Airlines Logo
9:00 am - 9:49 pmFSD-ECP
12h 49m3 stops
United Airlines Logo
3:00 pm - 11:43 pmECP-FSD
8h 43m2 stops
$799United Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
Delta Logo
5:16 am - 1:19 pmFSD-ECP
8h 03m1 stop
Delta Logo
4:41 pm - 12:33 pmECP-FSD
19h 52m2 stops
$809Delta
Find Deal
Thu, Dec 25 - Fri, Jan 2

American Airlines flights from Sioux Falls to Panama City, Florida

Our best American Airlines deals on Sioux Falls to Panama City, Florida flight tickets
American Airlines
Dec 6
FSD1:09 pmSioux Falls Joe Foss Field
6h 02m
1 stop
ECP7:11 pmPanama City NW Florida Beaches
Dec 9
ECP6:30 amPanama City NW Florida Beaches
5h 53m
1 stop
FSD12:23 pmSioux Falls Joe Foss Field
$259
Find similar
American Airlines
Dec 6
FSD2:02 pmSioux Falls Joe Foss Field
10h 02m
2 stops
ECP12:04 amPanama City NW Florida Beaches
Dec 9
ECP6:30 amPanama City NW Florida Beaches
5h 53m
1 stop
FSD12:23 pmSioux Falls Joe Foss Field
$264
Find similar
American Airlines
Dec 6
FSD11:37 amSioux Falls Joe Foss Field
12h 27m
2 stops
ECP12:04 amPanama City NW Florida Beaches
Dec 9
ECP12:08 pmPanama City NW Florida Beaches
10h 21m
2 stops
FSD10:29 pmSioux Falls Joe Foss Field
$269
Find similar

United Airlines flights from Sioux Falls to Panama City, Florida

Our best United Airlines deals on Sioux Falls to Panama City, Florida flight tickets
United Airlines
Dec 6
FSD8:00 amSioux Falls Joe Foss Field
13h 49m
3 stops
ECP9:49 pmPanama City NW Florida Beaches
Dec 9
ECP3:00 pmPanama City NW Florida Beaches
8h 43m
2 stops
FSD11:43 pmSioux Falls Joe Foss Field
$354
Find similar
United Airlines
Nov 10
FSD6:00 amSioux Falls Joe Foss Field
10h 03m
2 stops
ECP4:03 pmPanama City NW Florida Beaches
Nov 14
ECP5:00 pmPanama City NW Florida Beaches
23h 18m
2 stops
FSD4:18 pmSioux Falls Joe Foss Field
$663
Find similar
United Airlines
Nov 10
FSD11:17 amSioux Falls Joe Foss Field
10h 32m
2 stops
ECP9:49 pmPanama City NW Florida Beaches
Nov 14
ECP10:04 amPanama City NW Florida Beaches
30h 14m
2 stops
FSD4:18 pmSioux Falls Joe Foss Field
$673
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 4, 2025.
Use the filters below to find and compare flights from Sioux Falls to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

1:09 pm-7:11 pm

1 stop6h 02m

Panama City NW Florida Beaches

Tue 12/9

6:30 am-12:23 pm

1 stop5h 53m

$259

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

2:02 pm-12:04 am

2 stops10h 02m

Panama City NW Florida Beaches

Tue 12/9

6:30 am-12:23 pm

1 stop5h 53m

$264

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

11:37 am-12:04 am

2 stops12h 27m

Panama City NW Florida Beaches

Tue 12/9

12:08 pm-10:29 pm

2 stops10h 21m

$269

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 12/2

6:30 am-12:39 pm

1 stop6h 09m

Panama City NW Florida Beaches

Tue 12/9

6:30 am-12:23 pm

1 stop5h 53m

$324

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 12/6

8:00 am-9:49 pm

3 stops13h 49m

Panama City NW Florida Beaches

Tue 12/9

3:00 pm-11:43 pm

2 stops8h 43m

$354

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 3/2

5:08 am-11:20 am

1 stop6h 12m

Panama City NW Florida Beaches

Mon 3/2

6:03 pm-11:12 pm

1 stop5h 09m

$599

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Mon 3/2

5:00 am-1:27 pm

2 stops8h 27m

Panama City NW Florida Beaches

Mon 3/2

6:03 pm-11:12 pm

1 stop5h 09m

$682

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 12/3

11:20 am-9:49 pm

3 stops10h 29m

Panama City NW Florida Beaches

Wed 12/10

3:00 pm-11:43 pm

2 stops8h 43m

$750

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 12/2

9:00 am-9:49 pm

3 stops12h 49m

Panama City NW Florida Beaches

Tue 12/9

3:00 pm-11:43 pm

2 stops8h 43m

$799

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Thu 12/25

5:16 am-1:19 pm

1 stop8h 03m

Panama City NW Florida Beaches

Fri 1/2

4:41 pm-12:33 pm

2 stops19h 52m

$809

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Panama City from

How to get the cheapest flight ticket from Sioux Falls to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Sioux Falls is in January. Flight prices, which tend to average around $306, are often lower during this time because this is during the off-season. The month of July is another great option to travel to Panama City, Florida, with average flight prices from Sioux Falls averaging around $352.

What is the cheapest day to depart on your flight to Panama City, Florida?

Our data shows that Thursday is the least expensive day to fly to Panama City, Florida. Tickets to fly out on this day can be as low as $332. On the other hand, Wednesday is the most expensive day to depart from Sioux Falls because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $555.

When to book flights from Sioux Falls to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Panama City, Florida (FSD to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Panama City, Florida

Direct flights

None
There are no direct flights from Sioux Falls to Panama City, Florida. There are no popular flight routes from Sioux Falls to Panama City, Florida.
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  • How far is Sioux Falls Joe Foss Field to Panama City NW Florida Beaches by plane?

    The straight-line distance from Sioux Falls Joe Foss Field to Panama City NW Florida Beaches is 1106.0 mi. In terms of flight time, this usually takes a little over 6h 02m.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport are updated daily.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Sioux Falls to Panama City, Florida?

Best airlines flying from Sioux Falls to Panama City, Florida

Compare and see reviews for airlines that fly from Sioux Falls to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $254Free CancellationRating
7.4
9,002 reviews
Search United Airlines flights
DeltaPriceFrom $264Free CancellationRating
7.9
8,003 reviews
Search Delta flights
American AirlinesPriceFrom $274Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Panama City?

Finding the right flight to Panama City from Sioux Falls is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Sioux Falls to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Sioux Falls which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Sioux Falls to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Sioux Falls to Panama City.

I’m not ready to book a flight from Sioux Falls to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Sioux Falls and alert you when they change.

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