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Cheap flights from Sioux Falls to Panama City from $339

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Panama City departing on 3/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Sioux Falls to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
1:27 pm - 11:49 pm
FSD
-
ECP
10h 22m
2 stops
American Airlines Logo
3:00 pm - 10:55 pm
ECP
-
FSD
7h 55m
1 stop
$339American Airlines
Sat, Mar 7 - Thu, Mar 12
United Airlines Logo
7:43 am - 1:14 pm
FSD
-
ECP
5h 31m
1 stop
United Airlines Logo
2:10 pm - 10:02 pm
ECP
-
FSD
7h 52m
1 stop
$355United Airlines
Sat, Mar 7 - Thu, Mar 12
American Airlines Logo
6:50 am - 12:44 pm
FSD
-
ECP
5h 54m
1 stop
American Airlines Logo
6:41 am - 12:37 pm
ECP
-
FSD
5h 56m
1 stop
$389American Airlines
Wed, Mar 18 - Tue, Mar 24
American Airlines Logo
12:14 pm - 11:49 pm
FSD
-
ECP
11h 35m
2 stops
American Airlines Logo
3:38 pm - 9:40 pm
ECP
-
FSD
6h 02m
1 stop
$421American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
2:08 pm - 11:49 pm
FSD
-
ECP
9h 41m
2 stops
American Airlines Logo
8:20 am - 7:10 pm
ECP
-
FSD
10h 50m
2 stops
$427American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
12:14 pm - 10:41 am
FSD
-
ECP
22h 27m
1 stop
American Airlines Logo
3:38 pm - 9:40 pm
ECP
-
FSD
6h 02m
1 stop
$451American Airlines
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
1:27 pm - 11:49 pm
FSD
-
ECP
10h 22m
2 stops
American Airlines Logo
7:19 am - 7:10 pm
ECP
-
FSD
11h 51m
2 stops
$467American Airlines
Sat, Mar 7 - Thu, Mar 12
United Airlines Logo
7:30 am - 4:12 pm
FSD
-
ECP
8h 42m
2 stops
United Airlines Logo
2:25 pm - 10:07 pm
ECP
-
FSD
7h 42m
1 stop
$489United Airlines
Tue, Feb 10 - Sat, Feb 14
United Airlines Logo
7:30 am - 4:12 pm
FSD
-
ECP
8h 42m
2 stops
United Airlines Logo
6:30 am - 4:13 pm
ECP
-
FSD
9h 43m
2 stops
$494United Airlines
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
2:06 pm - 11:49 pm
FSD
-
ECP
9h 43m
2 stops
American Airlines Logo
8:20 am - 7:10 pm
ECP
-
FSD
10h 50m
2 stops
$496American Airlines
Wed, Mar 18 - Tue, Mar 24

American Airlines flights from Sioux Falls to Panama City, Florida

Our best American Airlines deals on Sioux Falls to Panama City, Florida flight tickets
American Airlines
Mar 18
FSD6:50 amSioux Falls Joe Foss Field
5h 54m
1 stop
ECP12:44 pmPanama City NW Florida Beaches
Mar 24
ECP6:41 amPanama City NW Florida Beaches
5h 56m
1 stop
FSD12:37 pmSioux Falls Joe Foss Field
$389
American Airlines
Feb 27
FSD7:42 pmSioux Falls Joe Foss Field
14h 19m
2 stops
ECP10:01 amPanama City NW Florida Beaches
Mar 6
ECP3:38 pmPanama City NW Florida Beaches
6h 02m
1 stop
FSD9:40 pmSioux Falls Joe Foss Field
$393
American Airlines
Feb 27
FSD7:42 pmSioux Falls Joe Foss Field
14h 59m
1 stop
ECP10:41 amPanama City NW Florida Beaches
Mar 6
ECP1:19 pmPanama City NW Florida Beaches
5h 51m
1 stop
FSD7:10 pmSioux Falls Joe Foss Field
$396

United Airlines flights from Sioux Falls to Panama City, Florida

Our best United Airlines deals on Sioux Falls to Panama City, Florida flight tickets
United Airlines
Feb 10
FSD7:30 amSioux Falls Joe Foss Field
8h 42m
2 stops
ECP4:12 pmPanama City NW Florida Beaches
Feb 14
ECP2:25 pmPanama City NW Florida Beaches
7h 42m
1 stop
FSD10:07 pmSioux Falls Joe Foss Field
$474
United Airlines
Feb 10
FSD7:30 amSioux Falls Joe Foss Field
8h 42m
2 stops
ECP4:12 pmPanama City NW Florida Beaches
Feb 14
ECP1:01 pmPanama City NW Florida Beaches
10h 48m
2 stops
FSD11:49 pmSioux Falls Joe Foss Field
$479
United Airlines
Feb 10
FSD7:30 amSioux Falls Joe Foss Field
8h 42m
2 stops
ECP4:12 pmPanama City NW Florida Beaches
Feb 14
ECP2:25 pmPanama City NW Florida Beaches
7h 42m
1 stop
FSD10:07 pmSioux Falls Joe Foss Field
$489

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 6, 2026.
Use the filters below to find and compare flights from Sioux Falls to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 3/7

1:27 pm-11:49 pm

2 stops10h 22m

Panama City NW Florida Beaches

Thu 3/12

3:00 pm-10:55 pm

1 stop7h 55m

$339

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 3/7

7:43 am-1:14 pm

1 stop5h 31m

Panama City NW Florida Beaches

Thu 3/12

2:10 pm-10:02 pm

1 stop7h 52m

$355

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 3/18

6:50 am-12:44 pm

1 stop5h 54m

Panama City NW Florida Beaches

Tue 3/24

6:41 am-12:37 pm

1 stop5h 56m

$389

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/20

12:14 pm-11:49 pm

2 stops11h 35m

Panama City NW Florida Beaches

Tue 2/24

3:38 pm-9:40 pm

1 stop6h 02m

$421

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/20

2:08 pm-11:49 pm

2 stops9h 41m

Panama City NW Florida Beaches

Tue 2/24

8:20 am-7:10 pm

2 stops10h 50m

$427

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Fri 2/20

12:14 pm-10:41 am

1 stop22h 27m

Panama City NW Florida Beaches

Tue 2/24

3:38 pm-9:40 pm

1 stop6h 02m

$451

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 3/7

1:27 pm-11:49 pm

2 stops10h 22m

Panama City NW Florida Beaches

Thu 3/12

7:19 am-7:10 pm

2 stops11h 51m

$467

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 2/10

7:30 am-4:12 pm

2 stops8h 42m

Panama City NW Florida Beaches

Sat 2/14

2:25 pm-10:07 pm

1 stop7h 42m

$489

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 2/10

7:30 am-4:12 pm

2 stops8h 42m

Panama City NW Florida Beaches

Sat 2/14

6:30 am-4:13 pm

2 stops9h 43m

$494

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Wed 3/18

2:06 pm-11:49 pm

2 stops9h 43m

Panama City NW Florida Beaches

Tue 3/24

8:20 am-7:10 pm

2 stops10h 50m

$496

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Sioux Falls to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Sioux Falls Joe Foss Field to Panama City NW Florida Beaches?

American Airlines is the most popular carrier operating from Sioux Falls Joe Foss Field to Panama City NW Florida Beaches

What airlines fly to Panama City, Florida?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Panama City, Florida from Sioux Falls according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to Panama City, Florida. Keep in mind that there are 3 different airlines that fly to Panama City, Florida on a routine basis, so you have a few additional options to choose from.

When to book flights from Sioux Falls to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Panama City, Florida (FSD to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Panama City, Florida

Fastest flight time

5h 03m

Direct flights

None
The fastest flight from Sioux Falls to Panama City, Florida takes 5h 03m
There are no direct flights from Sioux Falls to Panama City, Florida. There are no popular flight routes from Sioux Falls to Panama City, Florida.
Search flight deals

  • How far is Sioux Falls Joe Foss Field to Panama City NW Florida Beaches by plane?

    The straight-line distance from Sioux Falls Joe Foss Field to Panama City NW Florida Beaches is 1106.0 mi. In terms of flight time, this usually takes a little over 5h 03m.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport are updated daily.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Sioux Falls to Panama City, Florida?

Best airlines flying from Sioux Falls to Panama City, Florida

Compare and see reviews for airlines that fly from Sioux Falls to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $254Free CancellationRating
7.4
9,244 reviews
Search United Airlines flights
DeltaPriceFrom $264Free CancellationRating
7.9
8,159 reviews
Search Delta flights
American AirlinesPriceFrom $274Free CancellationRating
7.2
11,246 reviews
Search American Airlines flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Panama City?

Finding the right flight to Panama City from Sioux Falls is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Sioux Falls to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Sioux Falls which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Sioux Falls to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Sioux Falls to Panama City.

I’m not ready to book a flight from Sioux Falls to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Sioux Falls and alert you when they change.

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