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Cheap flights from Sioux Falls to Panama City from $291

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Panama City departing on 9/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Sioux Falls to Panama City

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:30 am - 12:40 pm
FSD
-
ECP
7h 10m
1 stop
Delta Logo
1:47 pm - 7:49 pm
ECP
-
FSD
6h 02m
1 stop
$291Delta
Tue, Sep 22 - Sat, Sep 26
Delta Logo
8:23 am - 3:31 pm
FSD
-
ECP
7h 08m
2 stops
Delta Logo
1:47 pm - 7:49 pm
ECP
-
FSD
6h 02m
1 stop
$296Delta
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:05 pm - 10:56 pm
FSD
-
ECP
9h 51m
2 stops
Delta Logo
7:35 am - 3:38 pm
ECP
-
FSD
8h 03m
2 stops
$301Delta
Tue, Sep 22 - Sat, Sep 26
Delta Logo
1:00 pm - 10:47 pm
FSD
-
ECP
9h 47m
2 stops
Delta Logo
4:10 pm - 10:12 pm
ECP
-
FSD
6h 02m
1 stop
$310Delta
Sat, Nov 7 - Wed, Nov 11
Delta Logo
1:26 pm - 11:30 pm
FSD
-
ECP
10h 04m
2 stops
Delta Logo
1:57 pm - 7:59 pm
ECP
-
FSD
6h 02m
1 stop
$324Delta
Thu, Aug 13 - Mon, Aug 17
American Airlines Logo
1:16 pm - 9:21 pm
FSD
-
ECP
8h 05m
1 stop
American Airlines Logo
3:22 pm - 9:09 pm
ECP
-
FSD
5h 47m
1 stop
$344American Airlines
Sat, Nov 7 - Wed, Nov 11
American Airlines Logo
1:43 pm - 11:49 pm
FSD
-
ECP
10h 06m
2 stops
American Airlines Logo
3:22 pm - 9:09 pm
ECP
-
FSD
5h 47m
1 stop
$349American Airlines
Sat, Nov 7 - Wed, Nov 11
American Airlines Logo
7:00 am - 5:32 pm
FSD
-
ECP
10h 32m
2 stops
American Airlines Logo
8:29 am - 6:11 pm
ECP
-
FSD
9h 42m
2 stops
$351American Airlines
Tue, Sep 22 - Sat, Sep 26
American Airlines Logo
1:16 pm - 9:21 pm
FSD
-
ECP
8h 05m
1 stop
American Airlines Logo
3:22 pm - 9:09 pm
ECP
-
FSD
5h 47m
1 stop
$370American Airlines
Sat, Nov 7 - Wed, Nov 11
American Airlines Logo
1:16 pm - 11:49 pm
FSD
-
ECP
10h 33m
2 stops
American Airlines Logo
7:10 am - 4:41 pm
ECP
-
FSD
9h 31m
2 stops
$379American Airlines
Sat, Nov 7 - Wed, Nov 11

Delta flights from Sioux Falls to Panama City, Florida

Our best Delta deals on Sioux Falls to Panama City, Florida flight tickets
Delta
Sep 22
FSD5:30 amSioux Falls Joe Foss Field
7h 10m
1 stop
ECP12:40 pmPanama City NW Florida Beaches
Sep 26
ECP1:47 pmPanama City NW Florida Beaches
6h 02m
1 stop
FSD7:49 pmSioux Falls Joe Foss Field
$291
Delta
Sep 22
FSD8:23 amSioux Falls Joe Foss Field
7h 08m
2 stops
ECP3:31 pmPanama City NW Florida Beaches
Sep 26
ECP1:47 pmPanama City NW Florida Beaches
6h 02m
1 stop
FSD7:49 pmSioux Falls Joe Foss Field
$296
Delta
Sep 22
FSD1:05 pmSioux Falls Joe Foss Field
9h 51m
2 stops
ECP10:56 pmPanama City NW Florida Beaches
Sep 26
ECP7:35 amPanama City NW Florida Beaches
8h 03m
2 stops
FSD3:38 pmSioux Falls Joe Foss Field
$301

American Airlines flights from Sioux Falls to Panama City, Florida

Our best American Airlines deals on Sioux Falls to Panama City, Florida flight tickets
American Airlines
Nov 7
FSD1:16 pmSioux Falls Joe Foss Field
8h 05m
1 stop
ECP9:21 pmPanama City NW Florida Beaches
Nov 11
ECP3:22 pmPanama City NW Florida Beaches
5h 47m
1 stop
FSD9:09 pmSioux Falls Joe Foss Field
$344
American Airlines
Nov 7
FSD1:43 pmSioux Falls Joe Foss Field
10h 06m
2 stops
ECP11:49 pmPanama City NW Florida Beaches
Nov 11
ECP3:22 pmPanama City NW Florida Beaches
5h 47m
1 stop
FSD9:09 pmSioux Falls Joe Foss Field
$349
American Airlines
Sep 22
FSD7:00 amSioux Falls Joe Foss Field
10h 32m
2 stops
ECP5:32 pmPanama City NW Florida Beaches
Sep 26
ECP8:29 amPanama City NW Florida Beaches
9h 42m
2 stops
FSD6:11 pmSioux Falls Joe Foss Field
$351

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Panama City, Florida that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Sioux Falls to Panama City, Florida that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

5:30 am-12:40 pm

1 stop7h 10m

Panama City NW Florida Beaches

Sat 9/26

1:47 pm-7:49 pm

1 stop6h 02m

$291
Quickest round-trip

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

8:23 am-3:31 pm

2 stops7h 08m

Panama City NW Florida Beaches

Sat 9/26

1:47 pm-7:49 pm

1 stop6h 02m

$296

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

1:05 pm-10:56 pm

2 stops9h 51m

Panama City NW Florida Beaches

Sat 9/26

7:35 am-3:38 pm

2 stops8h 03m

$301

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 11/7

1:00 pm-10:47 pm

2 stops9h 47m

Panama City NW Florida Beaches

Wed 11/11

4:10 pm-10:12 pm

1 stop6h 02m

$310

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Thu 8/13

1:26 pm-11:30 pm

2 stops10h 04m

Panama City NW Florida Beaches

Mon 8/17

1:57 pm-7:59 pm

1 stop6h 02m

$324

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 11/7

1:16 pm-9:21 pm

1 stop8h 05m

Panama City NW Florida Beaches

Wed 11/11

3:22 pm-9:09 pm

1 stop5h 47m

$344

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 11/7

1:43 pm-11:49 pm

2 stops10h 06m

Panama City NW Florida Beaches

Wed 11/11

3:22 pm-9:09 pm

1 stop5h 47m

$349

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Tue 9/22

7:00 am-5:32 pm

2 stops10h 32m

Panama City NW Florida Beaches

Sat 9/26

8:29 am-6:11 pm

2 stops9h 42m

$351

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 11/7

1:16 pm-9:21 pm

1 stop8h 05m

Panama City NW Florida Beaches

Wed 11/11

3:22 pm-9:09 pm

1 stop5h 47m

$370

Sioux FallsPanama City

FSD - ECP

FSDECP

Sioux Falls Joe Foss Field

Sat 11/7

1:16 pm-11:49 pm

2 stops10h 33m

Panama City NW Florida Beaches

Wed 11/11

7:10 am-4:41 pm

2 stops9h 31m

$379

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Panama City from

How to get the cheapest flight ticket from Sioux Falls to Panama City, Florida

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Panama City, Florida?

The cheapest month to fly to Panama City, Florida from Sioux Falls is in January. Flight prices, which tend to average around $0, are often lower during this time because this is during the off-season. The month of March is another great option to travel to Panama City, Florida, with average flight prices from Sioux Falls averaging around $316.

Can stopping save me money on Sioux Falls to Panama City, Florida flights?

You could potentially save up to 22% on your flight if you consider stops on a Sioux Falls to Panama City, Florida flight.

When to book flights from Sioux Falls to Panama City, Florida

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Panama City, Florida according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Panama City, Florida (FSD to ECP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Panama City, Florida

Fastest flight time

7h 06m

Direct flights

None
The fastest flight from Sioux Falls to Panama City, Florida takes 7h 06m
There are no direct flights from Sioux Falls to Panama City, Florida. There are no popular flight routes from Sioux Falls to Panama City, Florida.
Search flight deals

Frequently asked questions about flying from Sioux Falls to Panama City, Florida

  • How far is Sioux Falls Joe Foss Field to Panama City NW Florida Beaches by plane?

    The straight-line distance from Sioux Falls Joe Foss Field to Panama City NW Florida Beaches is 1106.0 mi. In terms of flight time, this usually takes a little over 7h 06m.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport are updated daily.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Sioux Falls Joe Foss Field Airport to Panama City NW Florida Beaches Airport.

  • What documentation or ID do you need to fly to Panama City NW Florida Beaches Airport?

    The required travel and health documents for your Panama City NW Florida Beaches Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Panama City NW Florida Beaches Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Sioux Falls to Panama City, Florida?

Best airlines flying from Sioux Falls to Panama City, Florida

Compare and see reviews for airlines that fly from Sioux Falls to Panama City, Florida with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $279Free CancellationRating
7.1
11,641 reviews
Search American Airlines flights
DeltaPriceFrom $303Free CancellationRating
7.8
8,395 reviews
Search Delta flights

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Panama City Beach
Rosemary Beach
Port St. Joe
Seaside
Mexico Beach
Seagrove Beach
Freeport

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Panama City?

Finding the right flight to Panama City from Sioux Falls is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Panama City quick and easy, saving you time and money.

Can I find flights from Sioux Falls to Panama City with flexible booking policies on momondo?

momondo does allow users to show only those flights to Panama City from Sioux Falls which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Sioux Falls to Panama City?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Sioux Falls to Panama City.

I’m not ready to book a flight from Sioux Falls to Panama City right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Panama City, momondo offers a useful price alert feature which will track prices for flights to Panama City from Sioux Falls and alert you when they change.

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