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Cheap flights from Sioux Falls to Knoxville from $259

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Knoxville departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Sioux Falls to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
3:13 pm - 8:47 pm
FSD
-
TYS
4h 34m
1 stop
United Airlines Logo
7:00 am - 10:46 am
TYS
-
FSD
4h 46m
1 stop
$299United Airlines
Tue, Mar 24 - Sat, Mar 28
United Airlines Logo
11:21 am - 11:44 pm
FSD
-
TYS
11h 23m
2 stops
United Airlines Logo
7:00 am - 10:46 am
TYS
-
FSD
4h 46m
1 stop
$304United Airlines
Tue, Mar 24 - Sat, Mar 28
Allegiant Air Logo
5:55 pm - 2:10 pm
FSD
-
TYS
19h 15m
1 stop
Allegiant Air Logo
8:30 am - 9:00 am
TYS
-
FSD
25h 30m
1 stop
$320Allegiant Air
Mon, Mar 30 - Wed, Apr 1
Allegiant Air Logo
5:55 pm - 2:10 pm
FSD
-
TYS
19h 15m
1 stop
Allegiant Air Logo
8:30 am - 9:00 am
TYS
-
FSD
25h 30m
1 stop
$332Allegiant Air
Mon, Mar 30 - Wed, Apr 1
Allegiant Air Logo
10:56 am - 11:12 am
FSD
-
TYS
23h 16m
1 stop
Allegiant Air Logo
7:40 am - 5:05 pm
TYS
-
FSD
10h 25m
1 stop
$343Allegiant Air
Mon, Mar 23 - Fri, Mar 27
Allegiant Air Logo
5:55 pm - 2:10 pm
FSD
-
TYS
19h 15m
1 stop
Allegiant Air Logo
2:14 pm - 9:00 am
TYS
-
FSD
19h 46m
1 stop
$345Allegiant Air
Mon, Mar 30 - Wed, Apr 1
American Airlines Logo
12:14 pm - 10:48 pm
FSD
-
TYS
9h 34m
2 stops
American Airlines Logo
5:00 am - 12:41 pm
TYS
-
FSD
8h 41m
2 stops
$361American Airlines
Tue, Mar 24 - Sat, Mar 28
Allegiant Air Logo
6:11 pm - 11:06 am
FSD
-
TYS
15h 55m
1 stop
Allegiant Air Logo
7:30 am - 5:21 pm
TYS
-
FSD
10h 51m
1 stop
$362Allegiant Air
Fri, May 8 - Mon, May 11
Allegiant Air Logo
10:45 am - 9:48 pm
FSD
-
TYS
10h 03m
1 stop
Allegiant Air Logo
7:30 am - 5:21 pm
TYS
-
FSD
10h 51m
1 stop
$380Allegiant Air
Fri, Apr 17 - Mon, Apr 20
Allegiant Air Logo
5:55 pm - 8:51 pm
FSD
-
TYS
25h 56m
1 stop
Allegiant Air Logo
8:58 am - 5:05 pm
TYS
-
FSD
9h 07m
1 stop
$381Allegiant Air
Fri, Mar 27 - Mon, Mar 30

United Airlines flights from Sioux Falls to Knoxville

Our best United Airlines deals on Sioux Falls to Knoxville flight tickets
United Airlines
Mar 24
FSD3:13 pmSioux Falls Joe Foss Field
4h 34m
1 stop
TYS8:47 pmKnoxville McGhee Tyson
Mar 28
TYS7:00 amKnoxville McGhee Tyson
4h 46m
1 stop
FSD10:46 amSioux Falls Joe Foss Field
$299
United Airlines
Mar 24
FSD11:21 amSioux Falls Joe Foss Field
11h 23m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Mar 28
TYS7:00 amKnoxville McGhee Tyson
4h 46m
1 stop
FSD10:46 amSioux Falls Joe Foss Field
$304
United Airlines
Aug 22
FSD1:19 pmSioux Falls Joe Foss Field
8h 19m
1 stop
TYS10:38 pmKnoxville McGhee Tyson
Aug 26
TYS5:57 pmKnoxville McGhee Tyson
6h 40m
1 stop
FSD11:37 pmSioux Falls Joe Foss Field
$359

American Airlines flights from Sioux Falls to Knoxville

Our best American Airlines deals on Sioux Falls to Knoxville flight tickets
American Airlines
Mar 24
FSD12:14 pmSioux Falls Joe Foss Field
9h 34m
2 stops
TYS10:48 pmKnoxville McGhee Tyson
Mar 28
TYS5:00 amKnoxville McGhee Tyson
8h 41m
2 stops
FSD12:41 pmSioux Falls Joe Foss Field
$361
American Airlines
Aug 3
FSD12:40 pmSioux Falls Joe Foss Field
8h 19m
1 stop
TYS9:59 pmKnoxville McGhee Tyson
Aug 10
TYS5:37 pmKnoxville McGhee Tyson
19h 41m
1 stop
FSD12:18 pmSioux Falls Joe Foss Field
$422
American Airlines
May 8
FSD1:41 pmSioux Falls Joe Foss Field
9h 18m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
May 11
TYS8:48 pmKnoxville McGhee Tyson
16h 11m
1 stop
FSD11:59 amSioux Falls Joe Foss Field
$432

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 3/24

3:13 pm-8:47 pm

1 stop4h 34m

Knoxville McGhee Tyson

Sat 3/28

7:00 am-10:46 am

1 stop4h 46m

$299

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 3/24

11:21 am-11:44 pm

2 stops11h 23m

Knoxville McGhee Tyson

Sat 3/28

7:00 am-10:46 am

1 stop4h 46m

$304

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 3/30

5:55 pm-2:10 pm

1 stop19h 15m

Knoxville McGhee Tyson

Wed 4/1

8:30 am-9:00 am

1 stop25h 30m

$320

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 3/30

5:55 pm-2:10 pm

1 stop19h 15m

Knoxville McGhee Tyson

Wed 4/1

8:30 am-9:00 am

1 stop25h 30m

$332

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 3/23

10:56 am-11:12 am

1 stop23h 16m

Knoxville McGhee Tyson

Fri 3/27

7:40 am-5:05 pm

1 stop10h 25m

$343

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 3/30

5:55 pm-2:10 pm

1 stop19h 15m

Knoxville McGhee Tyson

Wed 4/1

2:14 pm-9:00 am

1 stop19h 46m

$345

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 3/24

12:14 pm-10:48 pm

2 stops9h 34m

Knoxville McGhee Tyson

Sat 3/28

5:00 am-12:41 pm

2 stops8h 41m

$361

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 5/8

6:11 pm-11:06 am

1 stop15h 55m

Knoxville McGhee Tyson

Mon 5/11

7:30 am-5:21 pm

1 stop10h 51m

$362

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 4/17

10:45 am-9:48 pm

1 stop10h 03m

Knoxville McGhee Tyson

Mon 4/20

7:30 am-5:21 pm

1 stop10h 51m

$380

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 3/27

5:55 pm-8:51 pm

1 stop25h 56m

Knoxville McGhee Tyson

Mon 3/30

8:58 am-5:05 pm

1 stop9h 07m

$381

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Sioux Falls to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Sioux Falls and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Sioux Falls, with most prices found around $277. If you aren’t able to travel during the month of October, then book flights to Knoxville from Sioux Falls during September instead. Flights to Knoxville in September, while not as cheap as those in October, still average around $286.

Can stopping save me money on Sioux Falls to Knoxville flights?

You could potentially save up to 21% on your flight if you consider stops on a Sioux Falls to Knoxville flight.

When to book flights from Sioux Falls to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Knoxville (FSD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Knoxville

Fastest flight time

4h 53m

Direct flights

None
The fastest flight from Sioux Falls to Knoxville takes 4h 53m
There are no direct flights from Sioux Falls to Knoxville. There are no popular flight routes from Sioux Falls to Knoxville.
Search flight deals

  • How far is Sioux Falls Joe Foss Field to Knoxville McGhee Tyson by plane?

    The distance between Sioux Falls Joe Foss Field and Knoxville McGhee Tyson is about 856.6 mi. Flights usually cover this in 4h 53m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Sioux Falls to Knoxville?

Best airlines flying from Sioux Falls to Knoxville

Compare and see reviews for airlines that fly from Sioux Falls to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,435 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,286 reviews
Search Delta flights
United AirlinesPriceFrom $277Free CancellationRating
7.4
9,418 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Sioux Falls to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Sioux Falls to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Sioux Falls to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Sioux Falls to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Sioux Falls. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Sioux Falls to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Sioux Falls and alert you when they change.

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