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Cheap flights from Sioux Falls to Knoxville from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Knoxville departing on 8/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Sioux Falls to Knoxville

Cheap round-trip flights

American Airlines Logo
5:05 pm - 12:23 amFSD-TYS
6h 18m1 stop
American Airlines Logo
8:09 am - 12:03 pmTYS-FSD
4h 54m1 stop
$249American Airlines
Find Deal
Sat, Oct 25 - Tue, Oct 28
American Airlines Logo
5:05 pm - 12:23 amFSD-TYS
6h 18m1 stop
American Airlines Logo
8:15 am - 5:09 pmTYS-FSD
9h 54m2 stops
$254American Airlines
Find Deal
Sat, Oct 25 - Tue, Oct 28
American Airlines Logo
1:27 pm - 11:50 pmFSD-TYS
9h 23m2 stops
American Airlines Logo
11:44 am - 9:16 pmTYS-FSD
10h 32m2 stops
$259American Airlines
Find Deal
Sat, Oct 25 - Tue, Oct 28
American Airlines Logo
1:03 pm - 11:45 pmFSD-TYS
9h 42m2 stops
American Airlines Logo
5:05 am - 12:36 pmTYS-FSD
8h 31m2 stops
$284American Airlines
Find Deal
Wed, Nov 12 - Sun, Nov 23
American Airlines Logo
5:33 pm - 12:21 amFSD-TYS
5h 48m1 stop
American Airlines Logo
4:37 pm - 9:23 pmTYS-FSD
5h 46m1 stop
$296American Airlines
Find Deal
Wed, Sep 24 - Sat, Sep 27
Delta Logo
5:46 pm - 11:36 pmFSD-TYS
4h 50m1 stop
Delta Logo
5:45 am - 12:11 pmTYS-FSD
7h 26m2 stops
$299Delta
Find Deal
Wed, Sep 24 - Sat, Sep 27
Delta Logo
5:00 am - 5:03 pmFSD-TYS
11h 03m2 stops
Delta Logo
5:45 am - 12:11 pmTYS-FSD
7h 26m2 stops
$373Delta
Find Deal
Wed, Sep 24 - Sat, Sep 27
Delta Logo
2:30 pm - 11:48 pmFSD-TYS
8h 18m2 stops
Delta Logo
6:03 pm - 11:46 pmTYS-FSD
6h 43m1 stop
$376Delta
Find Deal
Thu, Sep 4 - Mon, Sep 8
United Airlines Logo
9:30 am - 10:50 pmFSD-TYS
12h 20m2 stops
United Airlines Logo
7:20 pm - 9:46 pmTYS-FSD
27h 26m3 stops
$459United Airlines
Find Deal
Sat, Oct 25 - Tue, Oct 28
United Airlines Logo
8:47 am - 11:59 pmFSD-TYS
14h 12m2 stops
United Airlines Logo
5:45 am - 9:46 pmTYS-FSD
17h 01m3 stops
$583United Airlines
Find Deal
Wed, Nov 12 - Sun, Nov 23

American Airlines flights from Sioux Falls to Knoxville

Our best American Airlines deals on Sioux Falls to Knoxville flight tickets
American Airlines
Oct 25
FSD5:05 pmSioux Falls Joe Foss Field
6h 18m
1 stop
TYS12:23 amKnoxville McGhee Tyson
Oct 28
TYS8:09 amKnoxville McGhee Tyson
4h 54m
1 stop
FSD12:03 pmSioux Falls Joe Foss Field
$249
Find similar
American Airlines
Oct 25
FSD5:05 pmSioux Falls Joe Foss Field
6h 18m
1 stop
TYS12:23 amKnoxville McGhee Tyson
Oct 28
TYS8:15 amKnoxville McGhee Tyson
9h 54m
2 stops
FSD5:09 pmSioux Falls Joe Foss Field
$254
Find similar
American Airlines
Oct 25
FSD1:27 pmSioux Falls Joe Foss Field
9h 23m
2 stops
TYS11:50 pmKnoxville McGhee Tyson
Oct 28
TYS11:44 amKnoxville McGhee Tyson
10h 32m
2 stops
FSD9:16 pmSioux Falls Joe Foss Field
$259
Find similar

United Airlines flights from Sioux Falls to Knoxville

Our best United Airlines deals on Sioux Falls to Knoxville flight tickets
United Airlines
Oct 25
FSD9:30 amSioux Falls Joe Foss Field
12h 20m
2 stops
TYS10:50 pmKnoxville McGhee Tyson
Oct 28
TYS7:20 pmKnoxville McGhee Tyson
27h 26m
3 stops
FSD9:46 pmSioux Falls Joe Foss Field
$459
Find similar
United Airlines
Nov 12
FSD8:47 amSioux Falls Joe Foss Field
14h 12m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Nov 23
TYS5:45 amKnoxville McGhee Tyson
17h 01m
3 stops
FSD9:46 pmSioux Falls Joe Foss Field
$583
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

5:05 pm-12:23 am

1 stop6h 18m

Knoxville McGhee Tyson

Tue 10/28

8:09 am-12:03 pm

1 stop4h 54m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

5:05 pm-12:23 am

1 stop6h 18m

Knoxville McGhee Tyson

Tue 10/28

8:15 am-5:09 pm

2 stops9h 54m

$254

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

1:27 pm-11:50 pm

2 stops9h 23m

Knoxville McGhee Tyson

Tue 10/28

11:44 am-9:16 pm

2 stops10h 32m

$259

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 11/12

1:03 pm-11:45 pm

2 stops9h 42m

Knoxville McGhee Tyson

Sun 11/23

5:05 am-12:36 pm

2 stops8h 31m

$284

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/24

5:33 pm-12:21 am

1 stop5h 48m

Knoxville McGhee Tyson

Sat 9/27

4:37 pm-9:23 pm

1 stop5h 46m

$296

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/24

5:46 pm-11:36 pm

1 stop4h 50m

Knoxville McGhee Tyson

Sat 9/27

5:45 am-12:11 pm

2 stops7h 26m

$299

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/24

5:00 am-5:03 pm

2 stops11h 03m

Knoxville McGhee Tyson

Sat 9/27

5:45 am-12:11 pm

2 stops7h 26m

$373

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 9/4

2:30 pm-11:48 pm

2 stops8h 18m

Knoxville McGhee Tyson

Mon 9/8

6:03 pm-11:46 pm

1 stop6h 43m

$376

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 10/25

9:30 am-10:50 pm

2 stops12h 20m

Knoxville McGhee Tyson

Tue 10/28

7:20 pm-9:46 pm

3 stops27h 26m

$459

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 11/12

8:47 am-11:59 pm

2 stops14h 12m

Knoxville McGhee Tyson

Sun 11/23

5:45 am-9:46 pm

3 stops17h 01m

$583

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Sioux Falls to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Sioux Falls, with most prices found around $293. If you aren’t able to travel during the month of September, then book flights to Knoxville from Sioux Falls during August instead. Flights to Knoxville in August, while not as cheap as those in September, still average around $323.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Sioux Falls to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $250. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Sioux Falls to Knoxville for around $551.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Sioux Falls to Knoxville when you can find flight prices for as low as $271. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $442.

When to book flights from Sioux Falls to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Knoxville (FSD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Knoxville

Direct flights

None
There are no direct flights from Sioux Falls to Knoxville. There are no popular flight routes from Sioux Falls to Knoxville.
Search flight deals

  • How far is Sioux Falls Joe Foss Field to Knoxville McGhee Tyson by plane?

    The distance between Sioux Falls Joe Foss Field and Knoxville McGhee Tyson is about 856.6 mi. Flights usually cover this in 4h 50m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Sioux Falls to Knoxville?

Best airlines flying from Sioux Falls to Knoxville

Compare and see reviews for airlines that fly from Sioux Falls to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $221Free CancellationRating
7.9
7,982 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
8,928 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Sioux Falls to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Sioux Falls to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Sioux Falls to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Sioux Falls to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Sioux Falls. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Sioux Falls to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Sioux Falls and alert you when they change.

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