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Cheap flights from Sioux Falls to Knoxville from $195

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Knoxville departing on 10/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Sioux Falls to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:22 pm - 8:38 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
24h 16m1 stop Orlando Sanford Intl
Allegiant Air Logo
9:28 pm - 9:19 amTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
12h 51m1 stop Tampa St. Petersburg
$306Allegiant Air
Sun, Oct 4 - Thu, Oct 8
Delta Logo
5:30 am - 11:18 amFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
4h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:11 pm - 7:55 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
4h 44m1 stop Atlanta Hartsfield-Jackson
$315Delta
Wed, Sep 30 - Wed, Oct 7
Delta Logo
5:30 am - 11:18 amFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
4h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:38 pm - 7:55 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
6h 17m1 stop Atlanta Hartsfield-Jackson
$315Delta
Wed, Sep 30 - Tue, Oct 6
Delta Logo
5:30 am - 11:18 amFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
4h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:16 pm - 11:22 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
5h 06m1 stop Minneapolis St Paul
$317Delta
Wed, Sep 30 - Thu, Oct 8
American Airlines Logo
3:22 pm - 11:47 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
7h 25m1 stop Chicago O'Hare Intl
American Airlines Logo
6:50 am - 12:28 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
6h 38m1 stop Dallas/Fort Worth
$319American Airlines
Fri, Dec 4 - Fri, Dec 11
American Airlines Logo
6:24 am - 12:51 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
5h 27m1 stop Chicago O'Hare Intl
American Airlines Logo
6:03 am - 12:17 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
7h 14m1 stop Dallas/Fort Worth
$334American Airlines
Wed, Aug 26 - Mon, Aug 31
Multiple Airlines Logo
8:52 pm - 8:13 amFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
34h 21m2 stops Denver Intl Tampa
Multiple Airlines Logo
9:28 pm - 9:19 amTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
12h 51m1 stop Tampa St. Petersburg
$344Multiple Airlines
Fri, Oct 2 - Thu, Oct 8
United Airlines Logo
1:33 pm - 10:29 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
7h 56m1 stop Denver Intl
United Airlines Logo
6:02 pm - 11:22 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
6h 20m1 stop Chicago O'Hare Intl
$349United Airlines
Fri, Aug 28 - Tue, Sep 1
Allegiant Air Logo
5:52 pm - 10:58 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
28h 06m1 stop Orlando Sanford Intl
Allegiant Air Logo
9:28 pm - 9:19 amTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
12h 51m1 stop Tampa St. Petersburg
$350Allegiant Air
Thu, Oct 1 - Thu, Oct 8
United Airlines Logo
9:35 am - 8:53 pmFSD  Sioux Falls Joe Foss Field-TYS Knoxville McGhee Tyson
10h 18m2 stops Denver Intl Chicago O'Hare Intl
United Airlines Logo
6:02 pm - 11:22 pmTYS  Knoxville McGhee Tyson-FSD Sioux Falls Joe Foss Field
6h 20m1 stop Chicago O'Hare Intl
$354United Airlines
Wed, Aug 26 - Sun, Aug 30

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Allegiant Air flights from Sioux Falls to Knoxville

Our best Allegiant Air deals on Sioux Falls to Knoxville flight tickets
Allegiant Air
Oct 4
FSD7:22 pmSioux Falls Joe Foss Field
24h 16m
1 stop
TYS8:38 pmKnoxville McGhee Tyson
Oct 8
TYS9:28 pmKnoxville McGhee Tyson
12h 51m
1 stop
FSD9:19 amSioux Falls Joe Foss Field
$306
Allegiant Air
Oct 1
FSD5:52 pmSioux Falls Joe Foss Field
28h 06m
1 stop
TYS10:58 pmKnoxville McGhee Tyson
Oct 8
TYS9:28 pmKnoxville McGhee Tyson
12h 51m
1 stop
FSD9:19 amSioux Falls Joe Foss Field
$350
Allegiant Air
Oct 4
FSD7:22 pmSioux Falls Joe Foss Field
24h 16m
1 stop
TYS8:38 pmKnoxville McGhee Tyson
Oct 7
TYS6:41 pmKnoxville McGhee Tyson
24h 25m
1 stop
FSD6:06 pmSioux Falls Joe Foss Field
$356

Delta flights from Sioux Falls to Knoxville

Our best Delta deals on Sioux Falls to Knoxville flight tickets
Delta
Sep 30
FSD5:30 amSioux Falls Joe Foss Field
4h 48m
1 stop
TYS11:18 amKnoxville McGhee Tyson
Oct 7
TYS4:11 pmKnoxville McGhee Tyson
4h 44m
1 stop
FSD7:55 pmSioux Falls Joe Foss Field
$315
Delta
Sep 30
FSD5:30 amSioux Falls Joe Foss Field
4h 48m
1 stop
TYS11:18 amKnoxville McGhee Tyson
Oct 8
TYS7:16 pmKnoxville McGhee Tyson
5h 06m
1 stop
FSD11:22 pmSioux Falls Joe Foss Field
$317
Delta
Oct 3
FSD4:28 pmSioux Falls Joe Foss Field
5h 46m
1 stop
TYS11:14 pmKnoxville McGhee Tyson
Oct 6
TYS2:38 pmKnoxville McGhee Tyson
6h 17m
1 stop
FSD7:55 pmSioux Falls Joe Foss Field
$362

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Sun 10/4

7:22 pm-8:38 pm

1 stop24h 16m

Knoxville McGhee Tyson

Thu 10/8

9:28 pm-9:19 am

1 stop12h 51m

$306
Quickest round-trip

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/30

5:30 am-11:18 am

1 stop4h 48m

Knoxville McGhee Tyson

Wed 10/7

4:11 pm-7:55 pm

1 stop4h 44m

$315

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/30

5:30 am-11:18 am

1 stop4h 48m

Knoxville McGhee Tyson

Tue 10/6

2:38 pm-7:55 pm

1 stop6h 17m

$315

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Wed 9/30

5:30 am-11:18 am

1 stop4h 48m

Knoxville McGhee Tyson

Thu 10/8

7:16 pm-11:22 pm

1 stop5h 06m

$317

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Fri 12/4

3:22 pm-11:47 pm

1 stop7h 25m

Knoxville McGhee Tyson

Fri 12/11

6:50 am-12:28 pm

1 stop6h 38m

$319

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Wed 8/26

6:24 am-12:51 pm

1 stop5h 27m

Knoxville McGhee Tyson

Mon 8/31

6:03 am-12:17 pm

1 stop7h 14m

$334

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Fri 10/2

8:52 pm-8:13 am

2 stops34h 21m

Knoxville McGhee Tyson

Thu 10/8

9:28 pm-9:19 am

1 stop12h 51m

$344

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Fri 8/28

1:33 pm-10:29 pm

1 stop7h 56m

Knoxville McGhee Tyson

Tue 9/1

6:02 pm-11:22 pm

1 stop6h 20m

$349

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Thu 10/1

5:52 pm-10:58 pm

1 stop28h 06m

Knoxville McGhee Tyson

Thu 10/8

9:28 pm-9:19 am

1 stop12h 51m

$350

Sioux FallsKnoxville

FSD Sioux Falls Joe Foss Field - TYS Knoxville McGhee Tyson

FSDTYS

Sioux Falls Joe Foss Field

Wed 8/26

9:35 am-8:53 pm

2 stops10h 18m

Knoxville McGhee Tyson

Sun 8/30

6:02 pm-11:22 pm

1 stop6h 20m

$354

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Sioux Falls to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Sioux Falls and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $436 to $456.
The lowest price recently found on this route was $306.

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Sioux Falls, with most prices found around $277. If you aren’t able to travel during the month of October, then book flights to Knoxville from Sioux Falls during April instead. Flights to Knoxville in April, while not as cheap as those in October, still average around $289.

Can stopping save me money on Sioux Falls to Knoxville flights?

You could potentially save up to 28% on your flight if you consider stops on a Sioux Falls to Knoxville flight.

When to book flights from Sioux Falls to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Knoxville (FSD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Knoxville

Fastest flight time

4h 41m

Direct flights

None
The fastest flight from Sioux Falls to Knoxville takes 4h 41m
There are no direct flights from Sioux Falls to Knoxville. There are no popular flight routes from Sioux Falls to Knoxville.
Search flight deals

Frequently asked questions about flying from Sioux Falls to Knoxville

  • How far is Sioux Falls Joe Foss Field to Knoxville McGhee Tyson by plane?

    The distance between Sioux Falls Joe Foss Field and Knoxville McGhee Tyson is about 856.6 mi. Flights usually cover this in 4h 41m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Sioux Falls to Knoxville?

Best airlines flying from Sioux Falls to Knoxville

Compare and see reviews for airlines that fly from Sioux Falls to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,941 reviews
Search American Airlines flights
DeltaPriceFrom $274Free CancellationRating
7.8
8,508 reviews
Search Delta flights
United AirlinesPriceFrom $277Free CancellationRating
7.4
10,111 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Sioux Falls to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Sioux Falls to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Sioux Falls to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Sioux Falls to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Sioux Falls. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Sioux Falls to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Sioux Falls and alert you when they change.

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