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Cheap flights from Sioux Falls to Knoxville from $249

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Knoxville departing on 1/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Sioux Falls to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
11:22 am - 4:53 pm
FSD
-
TYS
4h 31m1 stop
United Airlines Logo
11:10 am - 2:36 pm
TYS
-
FSD
4h 26m1 stop
$249United Airlines
Fri, Jan 9 - Wed, Jan 14
United Airlines Logo
11:22 am - 11:44 pm
FSD
-
TYS
11h 22m2 stops
United Airlines Logo
11:10 am - 2:36 pm
TYS
-
FSD
4h 26m1 stop
$254United Airlines
Fri, Jan 9 - Wed, Jan 14
United Airlines Logo
11:22 am - 11:44 pm
FSD
-
TYS
11h 22m2 stops
United Airlines Logo
11:10 am - 8:24 pm
TYS
-
FSD
10h 14m2 stops
$259United Airlines
Fri, Jan 9 - Wed, Jan 14
Allegiant Air Logo
7:26 pm - 4:36 pm
FSD
-
TYS
20h 10m1 stop
Allegiant Air Logo
8:30 am - 6:11 pm
TYS
-
FSD
10h 41m1 stop
$288Allegiant Air
Fri, Jan 23 - Mon, Jan 26
American Airlines Logo
7:00 am - 3:46 pm
FSD
-
TYS
7h 46m1 stop
American Airlines Logo
12:15 pm - 9:35 pm
TYS
-
FSD
10h 20m2 stops
$299American Airlines
Fri, Jan 23 - Mon, Jan 26
Delta Logo
11:00 am - 8:47 pm
FSD
-
TYS
8h 47m2 stops
Delta Logo
5:40 am - 12:22 pm
TYS
-
FSD
7h 42m2 stops
$304Delta
Sat, Jan 24 - Wed, Jan 28
United Airlines Logo
7:30 am - 1:24 pm
FSD
-
TYS
4h 54m1 stop
United Airlines Logo
11:10 am - 2:36 pm
TYS
-
FSD
4h 26m1 stop
$319United Airlines
Sat, Jan 24 - Wed, Jan 28
United Airlines Logo
7:30 am - 1:24 pm
FSD
-
TYS
4h 54m1 stop
United Airlines Logo
11:10 am - 8:24 pm
TYS
-
FSD
10h 14m2 stops
$324United Airlines
Sat, Jan 24 - Wed, Jan 28
United Airlines Logo
9:00 am - 8:52 pm
FSD
-
TYS
10h 52m2 stops
United Airlines Logo
11:10 am - 8:24 pm
TYS
-
FSD
10h 14m2 stops
$329United Airlines
Sat, Jan 24 - Wed, Jan 28
Multiple Airlines Logo
10:36 am - 12:51 pm
FSD
-
TYS
25h 15m1 stop
Multiple Airlines Logo
4:52 pm - 12:46 pm
TYS
-
FSD
44h 54m2 stops
$330Multiple Airlines
Thu, Dec 11 - Mon, Dec 15

United Airlines flights from Sioux Falls to Knoxville

Our best United Airlines deals on Sioux Falls to Knoxville flight tickets
United Airlines
Jan 9
FSD11:22 amSioux Falls Joe Foss Field
4h 31m
1 stop
TYS4:53 pmKnoxville McGhee Tyson
Jan 14
TYS11:10 amKnoxville McGhee Tyson
4h 26m
1 stop
FSD2:36 pmSioux Falls Joe Foss Field
$249
Find similar
United Airlines
Jan 9
FSD11:22 amSioux Falls Joe Foss Field
11h 22m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Jan 14
TYS11:10 amKnoxville McGhee Tyson
4h 26m
1 stop
FSD2:36 pmSioux Falls Joe Foss Field
$254
Find similar
United Airlines
Jan 9
FSD11:22 amSioux Falls Joe Foss Field
11h 22m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Jan 14
TYS11:10 amKnoxville McGhee Tyson
10h 14m
2 stops
FSD8:24 pmSioux Falls Joe Foss Field
$259
Find similar

Allegiant Air flights from Sioux Falls to Knoxville

Our best Allegiant Air deals on Sioux Falls to Knoxville flight tickets
Allegiant Air
Jan 23
FSD7:26 pmSioux Falls Joe Foss Field
20h 10m
1 stop
TYS4:36 pmKnoxville McGhee Tyson
Jan 26
TYS8:30 amKnoxville McGhee Tyson
10h 41m
1 stop
FSD6:11 pmSioux Falls Joe Foss Field
$288
Find similar
Allegiant Air
Dec 11
FSD10:36 amSioux Falls Joe Foss Field
25h 15m
1 stop
TYS12:51 pmKnoxville McGhee Tyson
Dec 13
TYS8:32 pmKnoxville McGhee Tyson
21h 33m
1 stop
FSD5:05 pmSioux Falls Joe Foss Field
$389
Find similar
Allegiant Air
Dec 18
FSD10:36 amSioux Falls Joe Foss Field
22h 55m
1 stop
TYS10:31 amKnoxville McGhee Tyson
Dec 22
TYS6:30 amKnoxville McGhee Tyson
28h 01m
1 stop
FSD9:31 amSioux Falls Joe Foss Field
$396
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/9

11:22 am-4:53 pm

1 stop4h 31m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-2:36 pm

1 stop4h 26m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/9

11:22 am-11:44 pm

2 stops11h 22m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-2:36 pm

1 stop4h 26m

$254

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/9

11:22 am-11:44 pm

2 stops11h 22m

Knoxville McGhee Tyson

Wed 1/14

11:10 am-8:24 pm

2 stops10h 14m

$259

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/23

7:26 pm-4:36 pm

1 stop20h 10m

Knoxville McGhee Tyson

Mon 1/26

8:30 am-6:11 pm

1 stop10h 41m

$288

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/23

7:00 am-3:46 pm

1 stop7h 46m

Knoxville McGhee Tyson

Mon 1/26

12:15 pm-9:35 pm

2 stops10h 20m

$299

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/24

11:00 am-8:47 pm

2 stops8h 47m

Knoxville McGhee Tyson

Wed 1/28

5:40 am-12:22 pm

2 stops7h 42m

$304

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/24

7:30 am-1:24 pm

1 stop4h 54m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-2:36 pm

1 stop4h 26m

$319

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/24

7:30 am-1:24 pm

1 stop4h 54m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-8:24 pm

2 stops10h 14m

$324

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 1/24

9:00 am-8:52 pm

2 stops10h 52m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-8:24 pm

2 stops10h 14m

$329

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 12/11

10:36 am-12:51 pm

1 stop25h 15m

Knoxville McGhee Tyson

Mon 12/15

4:52 pm-12:46 pm

2 stops44h 54m

$330

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Sioux Falls to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Sioux Falls and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Sioux Falls, with most prices found around $263. If you aren’t able to travel during the month of October, then book flights to Knoxville from Sioux Falls during September instead. Flights to Knoxville in September, while not as cheap as those in October, still average around $286.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Sioux Falls to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $250. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Sioux Falls to Knoxville for around $551.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Sioux Falls to Knoxville when you can find flight prices for as low as $271. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $442.

Can stopping save me money on Sioux Falls to Knoxville flights?

You could potentially save up to 26% on your flight if you consider stops on a Sioux Falls to Knoxville flight.

When to book flights from Sioux Falls to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Knoxville (FSD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Knoxville

Fastest flight time

4h 23m

Direct flights

None
The fastest flight from Sioux Falls to Knoxville takes 4h 23m
There are no direct flights from Sioux Falls to Knoxville. There are no popular flight routes from Sioux Falls to Knoxville.
Search flight deals

  • How far is Sioux Falls Joe Foss Field to Knoxville McGhee Tyson by plane?

    The distance between Sioux Falls Joe Foss Field and Knoxville McGhee Tyson is about 856.6 mi. Flights usually cover this in 4h 23m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Sioux Falls to Knoxville?

Best airlines flying from Sioux Falls to Knoxville

Compare and see reviews for airlines that fly from Sioux Falls to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,011 reviews
Search Delta flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
9,066 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Sioux Falls to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Sioux Falls to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Sioux Falls to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Sioux Falls to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Sioux Falls. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Sioux Falls to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Sioux Falls and alert you when they change.

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