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Cheap flights from Sioux Falls to Knoxville from $172

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Knoxville departing on 7/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Sioux Falls to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:34 pm - 11:51 pm
FSD
-
TYS
5h 17m
1 stop
American Airlines Logo
6:03 am - 12:17 pm
TYS
-
FSD
7h 14m
1 stop
$305American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
12:57 pm - 10:58 pm
FSD
-
TYS
9h 01m
2 stops
American Airlines Logo
6:03 am - 12:17 pm
TYS
-
FSD
7h 14m
1 stop
$310American Airlines
Wed, Aug 19 - Sat, Aug 22
American Airlines Logo
5:34 pm - 11:51 pm
FSD
-
TYS
5h 17m
1 stop
American Airlines Logo
6:03 am - 12:17 pm
TYS
-
FSD
7h 14m
1 stop
$322American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
5:35 pm - 11:55 pm
FSD
-
TYS
5h 20m
1 stop
American Airlines Logo
11:35 am - 4:13 pm
TYS
-
FSD
5h 38m
1 stop
$324American Airlines
Fri, Jun 26 - Fri, Jul 3
American Airlines Logo
5:35 pm - 11:55 pm
FSD
-
TYS
5h 20m
1 stop
American Airlines Logo
4:07 pm - 12:18 am
TYS
-
FSD
9h 11m
2 stops
$329American Airlines
Fri, Jun 26 - Fri, Jul 3
Delta Logo
4:28 pm - 11:00 pm
FSD
-
TYS
5h 32m
1 stop
Delta Logo
4:38 pm - 7:59 pm
TYS
-
FSD
4h 21m
1 stop
$339Delta
Mon, Aug 3 - Mon, Aug 10
American Airlines Logo
5:34 pm - 11:51 pm
FSD
-
TYS
5h 17m
1 stop
American Airlines Logo
7:19 am - 12:17 pm
TYS
-
FSD
5h 58m
1 stop
$345American Airlines
Sat, Aug 1 - Sat, Aug 8
American Airlines Logo
5:27 pm - 11:51 pm
FSD
-
TYS
5h 24m
1 stop
American Airlines Logo
5:31 pm - 9:58 pm
TYS
-
FSD
5h 27m
1 stop
$347American Airlines
Sat, Jul 11 - Sat, Jul 18
American Airlines Logo
12:57 pm - 10:58 pm
FSD
-
TYS
9h 01m
2 stops
American Airlines Logo
6:03 am - 12:17 pm
TYS
-
FSD
7h 14m
1 stop
$350American Airlines
Wed, Aug 26 - Tue, Sep 8
Allegiant Air Logo
6:36 pm - 9:15 pm
FSD
-
TYS
25h 39m
1 stop
Allegiant Air Logo
6:42 pm - 9:04 am
TYS
-
FSD
39h 22m
2 stops
$361Allegiant Air
Sun, Jul 5 - Sat, Jul 11

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Delta flights from Sioux Falls to Knoxville

Our best Delta deals on Sioux Falls to Knoxville flight tickets
Delta
Aug 3
FSD4:28 pmSioux Falls Joe Foss Field
5h 32m
1 stop
TYS11:00 pmKnoxville McGhee Tyson
Aug 10
TYS4:38 pmKnoxville McGhee Tyson
4h 21m
1 stop
FSD7:59 pmSioux Falls Joe Foss Field
$339
Delta
Aug 3
FSD4:28 pmSioux Falls Joe Foss Field
5h 32m
1 stop
TYS11:00 pmKnoxville McGhee Tyson
Aug 10
TYS6:35 amKnoxville McGhee Tyson
7h 03m
1 stop
FSD12:38 pmSioux Falls Joe Foss Field
$369

Allegiant Air flights from Sioux Falls to Knoxville

Our best Allegiant Air deals on Sioux Falls to Knoxville flight tickets
Allegiant Air
Jul 5
FSD6:36 pmSioux Falls Joe Foss Field
25h 39m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Jul 11
TYS6:42 pmKnoxville McGhee Tyson
39h 22m
2 stops
FSD9:04 amSioux Falls Joe Foss Field
$361
Allegiant Air
Jul 5
FSD6:36 pmSioux Falls Joe Foss Field
19h 22m
1 stop
TYS2:58 pmKnoxville McGhee Tyson
Jul 11
TYS8:40 pmKnoxville McGhee Tyson
37h 24m
2 stops
FSD9:04 amSioux Falls Joe Foss Field
$367
Allegiant Air
Jul 5
FSD6:36 pmSioux Falls Joe Foss Field
19h 22m
1 stop
TYS2:58 pmKnoxville McGhee Tyson
Jul 11
TYS5:59 pmKnoxville McGhee Tyson
24h 47m
1 stop
FSD5:46 pmSioux Falls Joe Foss Field
$380

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 8/1

5:34 pm-11:51 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sat 8/8

6:03 am-12:17 pm

1 stop7h 14m

$305

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 8/19

12:57 pm-10:58 pm

2 stops9h 01m

Knoxville McGhee Tyson

Sat 8/22

6:03 am-12:17 pm

1 stop7h 14m

$310

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 8/1

5:34 pm-11:51 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sat 8/8

6:03 am-12:17 pm

1 stop7h 14m

$322

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 6/26

5:35 pm-11:55 pm

1 stop5h 20m

Knoxville McGhee Tyson

Fri 7/3

11:35 am-4:13 pm

1 stop5h 38m

$324

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 6/26

5:35 pm-11:55 pm

1 stop5h 20m

Knoxville McGhee Tyson

Fri 7/3

4:07 pm-12:18 am

2 stops9h 11m

$329
Quickest round-trip

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 8/3

4:28 pm-11:00 pm

1 stop5h 32m

Knoxville McGhee Tyson

Mon 8/10

4:38 pm-7:59 pm

1 stop4h 21m

$339

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 8/1

5:34 pm-11:51 pm

1 stop5h 17m

Knoxville McGhee Tyson

Sat 8/8

7:19 am-12:17 pm

1 stop5h 58m

$345

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 7/11

5:27 pm-11:51 pm

1 stop5h 24m

Knoxville McGhee Tyson

Sat 7/18

5:31 pm-9:58 pm

1 stop5h 27m

$347

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Wed 8/26

12:57 pm-10:58 pm

2 stops9h 01m

Knoxville McGhee Tyson

Tue 9/8

6:03 am-12:17 pm

1 stop7h 14m

$350

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sun 7/5

6:36 pm-9:15 pm

1 stop25h 39m

Knoxville McGhee Tyson

Sat 7/11

6:42 pm-9:04 am

2 stops39h 22m

$361

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Sioux Falls to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Sioux Falls and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Sioux Falls, with most prices found around $277. If you aren’t able to travel during the month of October, then book flights to Knoxville from Sioux Falls during April instead. Flights to Knoxville in April, while not as cheap as those in October, still average around $289.

Can stopping save me money on Sioux Falls to Knoxville flights?

You could potentially save up to 34% on your flight if you consider stops on a Sioux Falls to Knoxville flight.

When to book flights from Sioux Falls to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Knoxville (FSD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Knoxville

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Sioux Falls to Knoxville takes 4h 45m
There are no direct flights from Sioux Falls to Knoxville. There are no popular flight routes from Sioux Falls to Knoxville.
Search flight deals

Frequently asked questions about flying from Sioux Falls to Knoxville

  • How far is Sioux Falls Joe Foss Field to Knoxville McGhee Tyson by plane?

    The distance between Sioux Falls Joe Foss Field and Knoxville McGhee Tyson is about 856.6 mi. Flights usually cover this in 4h 45m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Sioux Falls to Knoxville?

Best airlines flying from Sioux Falls to Knoxville

Compare and see reviews for airlines that fly from Sioux Falls to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,660 reviews
Search American Airlines flights
DeltaPriceFrom $274Free CancellationRating
7.9
8,396 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Sioux Falls to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Sioux Falls to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Sioux Falls to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Sioux Falls to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Sioux Falls. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Sioux Falls to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Sioux Falls and alert you when they change.

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