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Cheap flights from Sioux Falls to Knoxville from $237

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Knoxville departing on 10/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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American Airlines Logo
5:27 pm - 12:08 amFSD-TYS
5h 41m1 stop
American Airlines Logo
6:16 pm - 10:27 pmTYS-FSD
5h 11m1 stop
$249American Airlines
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Sat, Nov 8 - Wed, Nov 12
American Airlines Logo
5:27 pm - 12:08 amFSD-TYS
5h 41m1 stop
American Airlines Logo
6:00 am - 2:45 pmTYS-FSD
9h 45m2 stops
$254American Airlines
Find Deal
Sat, Nov 8 - Wed, Nov 12
Delta Logo
1:20 pm - 9:32 pmFSD-TYS
7h 12m2 stops
Delta Logo
7:30 am - 3:33 pmTYS-FSD
9h 03m2 stops
$270Delta
Find Deal
Fri, Jan 9 - Sat, Jan 17
Allegiant Air Logo
10:15 am - 8:29 pmFSD-TYS
9h 14m1 stop
Allegiant Air Logo
8:00 am - 8:43 amTYS-FSD
25h 43m1 stop
$282Allegiant Air
Find Deal
Mon, Nov 17 - Thu, Nov 20
Delta Logo
1:20 pm - 9:32 pmFSD-TYS
7h 12m2 stops
Delta Logo
7:30 am - 3:33 pmTYS-FSD
9h 03m2 stops
$304Delta
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Tue, Feb 24 - Sat, Feb 28
Multiple Airlines Logo
10:15 am - 8:29 pmFSD-TYS
9h 14m1 stop
Multiple Airlines Logo
6:30 am - 10:56 amTYS-FSD
29h 26m2 stops
$312Multiple Airlines
Find Deal
Mon, Nov 17 - Thu, Nov 20
United Airlines Logo
3:15 pm - 10:55 pmFSD-TYS
6h 40m1 stop
United Airlines Logo
10:50 am - 8:23 pmTYS-FSD
10h 33m2 stops
$324United Airlines
Find Deal
Sat, Nov 8 - Wed, Nov 12
Multiple Airlines Logo
9:17 am - 10:47 pmFSD-TYS
12h 30m1 stop
Multiple Airlines Logo
8:30 am - 8:02 pmTYS-FSD
12h 32m2 stops
$379Multiple Airlines
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Thu, Oct 30 - Mon, Nov 3
United Airlines Logo
8:00 am - 6:04 pmFSD-TYS
9h 04m2 stops
United Airlines Logo
10:50 am - 8:23 pmTYS-FSD
10h 33m2 stops
$395United Airlines
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Sat, Nov 8 - Wed, Nov 12
Allegiant Air Logo
10:42 am - 11:38 pmFSD-TYS
35h 56m2 stops
Allegiant Air Logo
8:00 am - 9:50 pmTYS-FSD
14h 50m1 stop
$668Allegiant Air
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Fri, Dec 26 - Fri, Jan 2

Delta flights from Sioux Falls to Knoxville

Our best Delta deals on Sioux Falls to Knoxville flight tickets
Delta
Jan 9
FSD1:20 pmSioux Falls Joe Foss Field
7h 12m
2 stops
TYS9:32 pmKnoxville McGhee Tyson
Jan 17
TYS7:30 amKnoxville McGhee Tyson
9h 03m
2 stops
FSD3:33 pmSioux Falls Joe Foss Field
$270
Find similar
Delta
Feb 24
FSD1:20 pmSioux Falls Joe Foss Field
7h 12m
2 stops
TYS9:32 pmKnoxville McGhee Tyson
Feb 28
TYS7:30 amKnoxville McGhee Tyson
9h 03m
2 stops
FSD3:33 pmSioux Falls Joe Foss Field
$304
Find similar
Delta
Feb 24
FSD4:09 pmSioux Falls Joe Foss Field
5h 51m
1 stop
TYS11:00 pmKnoxville McGhee Tyson
Feb 28
TYS7:30 amKnoxville McGhee Tyson
9h 03m
2 stops
FSD3:33 pmSioux Falls Joe Foss Field
$340
Find similar

American Airlines flights from Sioux Falls to Knoxville

Our best American Airlines deals on Sioux Falls to Knoxville flight tickets
American Airlines
Nov 8
FSD5:27 pmSioux Falls Joe Foss Field
5h 41m
1 stop
TYS12:08 amKnoxville McGhee Tyson
Nov 12
TYS6:16 pmKnoxville McGhee Tyson
5h 11m
1 stop
FSD10:27 pmSioux Falls Joe Foss Field
$249
Find similar
American Airlines
Nov 8
FSD5:27 pmSioux Falls Joe Foss Field
5h 41m
1 stop
TYS12:08 amKnoxville McGhee Tyson
Nov 12
TYS6:00 amKnoxville McGhee Tyson
9h 45m
2 stops
FSD2:45 pmSioux Falls Joe Foss Field
$254
Find similar
American Airlines
Nov 12
FSD1:03 pmSioux Falls Joe Foss Field
9h 56m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
Nov 23
TYS5:05 amKnoxville McGhee Tyson
9h 08m
2 stops
FSD1:13 pmSioux Falls Joe Foss Field
$259
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 11/8

5:27 pm-12:08 am

1 stop5h 41m

Knoxville McGhee Tyson

Wed 11/12

6:16 pm-10:27 pm

1 stop5h 11m

$249

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 11/8

5:27 pm-12:08 am

1 stop5h 41m

Knoxville McGhee Tyson

Wed 11/12

6:00 am-2:45 pm

2 stops9h 45m

$254

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 1/9

1:20 pm-9:32 pm

2 stops7h 12m

Knoxville McGhee Tyson

Sat 1/17

7:30 am-3:33 pm

2 stops9h 03m

$270

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 11/17

10:15 am-8:29 pm

1 stop9h 14m

Knoxville McGhee Tyson

Thu 11/20

8:00 am-8:43 am

1 stop25h 43m

$282

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Tue 2/24

1:20 pm-9:32 pm

2 stops7h 12m

Knoxville McGhee Tyson

Sat 2/28

7:30 am-3:33 pm

2 stops9h 03m

$304

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Mon 11/17

10:15 am-8:29 pm

1 stop9h 14m

Knoxville McGhee Tyson

Thu 11/20

6:30 am-10:56 am

2 stops29h 26m

$312

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 11/8

3:15 pm-10:55 pm

1 stop6h 40m

Knoxville McGhee Tyson

Wed 11/12

10:50 am-8:23 pm

2 stops10h 33m

$324

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Thu 10/30

9:17 am-10:47 pm

1 stop12h 30m

Knoxville McGhee Tyson

Mon 11/3

8:30 am-8:02 pm

2 stops12h 32m

$379

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Sat 11/8

8:00 am-6:04 pm

2 stops9h 04m

Knoxville McGhee Tyson

Wed 11/12

10:50 am-8:23 pm

2 stops10h 33m

$395

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

Fri 12/26

10:42 am-11:38 pm

2 stops35h 56m

Knoxville McGhee Tyson

Fri 1/2

8:00 am-9:50 pm

1 stop14h 50m

$668

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Sioux Falls to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Sioux Falls, with most prices found around $286. If you aren’t able to travel during the month of September, then book flights to Knoxville from Sioux Falls during October instead. Flights to Knoxville in October, while not as cheap as those in September, still average around $306.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Sioux Falls to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $250. When flying out on a Thursday, the most expensive travel day of the week, you can expect to see flight prices from Sioux Falls to Knoxville for around $551.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Sioux Falls to Knoxville when you can find flight prices for as low as $271. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $442.

When to book flights from Sioux Falls to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Knoxville (FSD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Knoxville

Direct flights

None
There are no direct flights from Sioux Falls to Knoxville. There are no popular flight routes from Sioux Falls to Knoxville.
Search flight deals

  • How far is Sioux Falls Joe Foss Field to Knoxville McGhee Tyson by plane?

    The distance between Sioux Falls Joe Foss Field and Knoxville McGhee Tyson is about 856.6 mi. Flights usually cover this in 3h 54m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Sioux Falls to Knoxville?

Best airlines flying from Sioux Falls to Knoxville

Compare and see reviews for airlines that fly from Sioux Falls to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $248Free CancellationRating
7.9
7,984 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
8,982 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Sioux Falls to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Sioux Falls to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Sioux Falls to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Sioux Falls to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Sioux Falls. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Sioux Falls to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Sioux Falls and alert you when they change.

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