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Cheap flights from Sioux Falls to Knoxville from $249

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Knoxville departing on 5/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Sioux Falls to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:28 pm - 11:56 pm
FSD
-
TYS
5h 28m
1 stop
American Airlines Logo
5:44 am - 1:01 pm
TYS
-
FSD
8h 17m
1 stop
$269American Airlines
mié., abr. 29 - mié., may. 6
Delta Logo
5:10 am - 11:15 am
FSD
-
TYS
5h 05m
1 stop
Delta Logo
5:15 pm - 10:46 pm
TYS
-
FSD
6h 31m
2 stops
$274Delta
mar., abr. 28 - vie., may. 8
Delta Logo
5:10 am - 4:49 pm
FSD
-
TYS
10h 39m
2 stops
Delta Logo
5:15 pm - 10:46 pm
TYS
-
FSD
6h 31m
2 stops
$280Delta
mar., abr. 28 - vie., may. 8
United Airlines Logo
7:39 am - 1:17 pm
FSD
-
TYS
4h 38m
1 stop
United Airlines Logo
7:00 am - 10:42 am
TYS
-
FSD
4h 42m
1 stop
$283United Airlines
sáb., abr. 4 - sáb., abr. 11
American Airlines Logo
5:21 pm - 11:51 pm
FSD
-
TYS
5h 30m
1 stop
American Airlines Logo
5:40 am - 12:41 pm
TYS
-
FSD
8h 01m
1 stop
$295American Airlines
sáb., mar. 28 - sáb., abr. 4
American Airlines Logo
12:14 pm - 6:37 pm
FSD
-
TYS
5h 23m
1 stop
American Airlines Logo
5:00 am - 11:42 am
TYS
-
FSD
7h 42m
2 stops
$300American Airlines
sáb., abr. 4 - sáb., abr. 11
American Airlines Logo
12:14 pm - 8:24 pm
FSD
-
TYS
7h 10m
2 stops
American Airlines Logo
11:40 am - 7:14 pm
TYS
-
FSD
8h 34m
2 stops
$305American Airlines
sáb., abr. 4 - sáb., abr. 11
Delta Logo
5:11 am - 1:50 pm
FSD
-
TYS
7h 39m
1 stop
Delta Logo
5:00 pm - 11:10 pm
TYS
-
FSD
7h 10m
1 stop
$309Delta
mié., feb. 4 - dom., feb. 8
Allegiant Air Logo
10:45 am - 9:48 pm
FSD
-
TYS
10h 03m
1 stop
Allegiant Air Logo
9:40 pm - 5:21 pm
TYS
-
FSD
20h 41m
1 stop
$315Allegiant Air
lun., abr. 27 - jue., may. 7
Delta Logo
5:10 am - 11:15 am
FSD
-
TYS
5h 05m
1 stop
Delta Logo
7:46 am - 3:37 pm
TYS
-
FSD
8h 51m
2 stops
$319Delta
mar., abr. 28 - sáb., may. 2

Delta flights from Sioux Falls to Knoxville

Our best Delta deals on Sioux Falls to Knoxville flight tickets
Delta
Apr 28
FSD5:10 amSioux Falls Joe Foss Field
5h 05m
1 stop
TYS11:15 amKnoxville McGhee Tyson
May 8
TYS5:15 pmKnoxville McGhee Tyson
6h 31m
2 stops
FSD10:46 pmSioux Falls Joe Foss Field
$274
Delta
Apr 28
FSD5:10 amSioux Falls Joe Foss Field
10h 39m
2 stops
TYS4:49 pmKnoxville McGhee Tyson
May 8
TYS5:15 pmKnoxville McGhee Tyson
6h 31m
2 stops
FSD10:46 pmSioux Falls Joe Foss Field
$280
Delta
Feb 4
FSD5:11 amSioux Falls Joe Foss Field
7h 39m
1 stop
TYS1:50 pmKnoxville McGhee Tyson
Feb 8
TYS5:00 pmKnoxville McGhee Tyson
7h 10m
1 stop
FSD11:10 pmSioux Falls Joe Foss Field
$309

United Airlines flights from Sioux Falls to Knoxville

Our best United Airlines deals on Sioux Falls to Knoxville flight tickets
United Airlines
Apr 4
FSD7:39 amSioux Falls Joe Foss Field
4h 38m
1 stop
TYS1:17 pmKnoxville McGhee Tyson
Apr 11
TYS7:00 amKnoxville McGhee Tyson
4h 42m
1 stop
FSD10:42 amSioux Falls Joe Foss Field
$283
United Airlines
Apr 28
FSD7:39 amSioux Falls Joe Foss Field
4h 38m
1 stop
TYS1:17 pmKnoxville McGhee Tyson
May 2
TYS7:00 amKnoxville McGhee Tyson
4h 42m
1 stop
FSD10:42 amSioux Falls Joe Foss Field
$339
United Airlines
Apr 29
FSD11:15 amSioux Falls Joe Foss Field
10h 48m
2 stops
TYS11:03 pmKnoxville McGhee Tyson
May 2
TYS7:00 amKnoxville McGhee Tyson
4h 42m
1 stop
FSD10:42 amSioux Falls Joe Foss Field
$344

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated enero 20, 2026.
Use the filters below to find and compare flights from Sioux Falls to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

mié. 4/29

5:28 pm-11:56 pm

1 stop5h 28m

Knoxville McGhee Tyson

mié. 5/6

5:44 am-1:01 pm

1 stop8h 17m

$269

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

mar. 4/28

5:10 am-11:15 am

1 stop5h 05m

Knoxville McGhee Tyson

vie. 5/8

5:15 pm-10:46 pm

2 stops6h 31m

$274

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

mar. 4/28

5:10 am-4:49 pm

2 stops10h 39m

Knoxville McGhee Tyson

vie. 5/8

5:15 pm-10:46 pm

2 stops6h 31m

$280

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sáb. 4/4

7:39 am-1:17 pm

1 stop4h 38m

Knoxville McGhee Tyson

sáb. 4/11

7:00 am-10:42 am

1 stop4h 42m

$283

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sáb. 3/28

5:21 pm-11:51 pm

1 stop5h 30m

Knoxville McGhee Tyson

sáb. 4/4

5:40 am-12:41 pm

1 stop8h 01m

$295

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sáb. 4/4

12:14 pm-6:37 pm

1 stop5h 23m

Knoxville McGhee Tyson

sáb. 4/11

5:00 am-11:42 am

2 stops7h 42m

$300

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

sáb. 4/4

12:14 pm-8:24 pm

2 stops7h 10m

Knoxville McGhee Tyson

sáb. 4/11

11:40 am-7:14 pm

2 stops8h 34m

$305

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

mié. 2/4

5:11 am-1:50 pm

1 stop7h 39m

Knoxville McGhee Tyson

dom. 2/8

5:00 pm-11:10 pm

1 stop7h 10m

$309

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

lun. 4/27

10:45 am-9:48 pm

1 stop10h 03m

Knoxville McGhee Tyson

jue. 5/7

9:40 pm-5:21 pm

1 stop20h 41m

$315

Sioux FallsKnoxville

FSD - TYS

FSDTYS

Sioux Falls Joe Foss Field

mar. 4/28

5:10 am-11:15 am

1 stop5h 05m

Knoxville McGhee Tyson

sáb. 5/2

7:46 am-3:37 pm

2 stops8h 51m

$319

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Sioux Falls to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Sioux Falls, with most prices found around $263. If you aren’t able to travel during the month of October, then book flights to Knoxville from Sioux Falls during September instead. Flights to Knoxville in September, while not as cheap as those in October, still average around $286.

Can stopping save me money on Sioux Falls to Knoxville flights?

You could potentially save up to 26% on your flight if you consider stops on a Sioux Falls to Knoxville flight.

When to book flights from Sioux Falls to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Knoxville (FSD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Knoxville

Fastest flight time

4h 22m

Direct flights

None
The fastest flight from Sioux Falls to Knoxville takes 4h 22m
There are no direct flights from Sioux Falls to Knoxville. There are no popular flight routes from Sioux Falls to Knoxville.
Search flight deals

  • How far is Sioux Falls Joe Foss Field to Knoxville McGhee Tyson by plane?

    The distance between Sioux Falls Joe Foss Field and Knoxville McGhee Tyson is about 856.6 mi. Flights usually cover this in 4h 22m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Sioux Falls Joe Foss Field Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Sioux Falls to Knoxville?

Best airlines flying from Sioux Falls to Knoxville

Compare and see reviews for airlines that fly from Sioux Falls to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,164 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,080 reviews
Search Delta flights
United AirlinesPriceFrom $268Free CancellationRating
7.4
9,183 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Murphy
Alcoa
Crossville
Maryville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Sioux Falls to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Sioux Falls to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Sioux Falls to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Sioux Falls to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Sioux Falls. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Sioux Falls to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Sioux Falls and alert you when they change.

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