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Cheap flights from Sioux Falls to Key West from $221

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Sioux Falls to Key West departing on 8/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Sioux Falls to Key West

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:29 pm - 10:58 pm
FSD
-
EYW
9h 29m
2 stops
American Airlines Logo
2:29 pm - 9:54 pm
EYW
-
FSD
8h 25m
1 stop
$288American Airlines
Tue, May 5 - Tue, May 12
American Airlines Logo
5:44 am - 7:12 pm
FSD
-
EYW
12h 28m
2 stops
American Airlines Logo
2:25 pm - 9:40 pm
EYW
-
FSD
8h 15m
1 stop
$341American Airlines
Tue, Mar 24 - Wed, Apr 1
Multiple Airlines Logo
5:55 pm - 11:30 am
FSD
-
EYW
16h 35m
1 stop
Multiple Airlines Logo
12:25 pm - 5:05 pm
EYW
-
FSD
29h 40m
1 stop
$342Multiple Airlines
Mon, Mar 23 - Sun, Mar 29
American Airlines Logo
12:29 pm - 10:58 pm
FSD
-
EYW
9h 29m
2 stops
American Airlines Logo
11:24 am - 11:06 pm
EYW
-
FSD
12h 42m
2 stops
$346American Airlines
Tue, May 5 - Tue, May 12
Multiple Airlines Logo
5:55 pm - 11:30 am
FSD
-
EYW
16h 35m
1 stop
Multiple Airlines Logo
12:25 pm - 5:05 pm
EYW
-
FSD
29h 40m
1 stop
$347Multiple Airlines
Mon, Mar 23 - Sun, Mar 29
Multiple Airlines Logo
5:55 pm - 12:21 pm
FSD
-
EYW
17h 26m
2 stops
Multiple Airlines Logo
12:25 pm - 5:05 pm
EYW
-
FSD
29h 40m
1 stop
$374Multiple Airlines
Mon, Mar 23 - Sun, Mar 29
American Airlines Logo
6:45 am - 7:15 pm
FSD
-
EYW
11h 30m
2 stops
American Airlines Logo
2:45 pm - 9:40 pm
EYW
-
FSD
7h 55m
1 stop
$379American Airlines
Wed, Feb 25 - Wed, Mar 4
American Airlines Logo
6:45 am - 7:15 pm
FSD
-
EYW
11h 30m
2 stops
American Airlines Logo
8:04 am - 7:10 pm
EYW
-
FSD
12h 06m
2 stops
$385American Airlines
Wed, Feb 25 - Wed, Mar 4
American Airlines Logo
5:44 am - 7:15 pm
FSD
-
EYW
12h 31m
2 stops
American Airlines Logo
2:45 pm - 9:40 pm
EYW
-
FSD
7h 55m
1 stop
$394American Airlines
Wed, Feb 25 - Wed, Mar 4
American Airlines Logo
6:45 am - 7:15 pm
FSD
-
EYW
11h 30m
2 stops
American Airlines Logo
12:55 pm - 9:40 pm
EYW
-
FSD
9h 45m
2 stops
$399American Airlines
Wed, Feb 25 - Wed, Mar 4

American Airlines flights from Sioux Falls to Key West

Our best American Airlines deals on Sioux Falls to Key West flight tickets
American Airlines
May 5
FSD12:29 pmSioux Falls Joe Foss Field
9h 29m
2 stops
EYW10:58 pmKey West
May 12
EYW2:29 pmKey West
8h 25m
1 stop
FSD9:54 pmSioux Falls Joe Foss Field
$288
American Airlines
Mar 24
FSD5:44 amSioux Falls Joe Foss Field
12h 28m
2 stops
EYW7:12 pmKey West
Apr 1
EYW2:25 pmKey West
8h 15m
1 stop
FSD9:40 pmSioux Falls Joe Foss Field
$341
American Airlines
May 5
FSD12:29 pmSioux Falls Joe Foss Field
9h 29m
2 stops
EYW10:58 pmKey West
May 12
EYW11:24 amKey West
12h 42m
2 stops
FSD11:06 pmSioux Falls Joe Foss Field
$346

United Airlines flights from Sioux Falls to Key West

Our best United Airlines deals on Sioux Falls to Key West flight tickets
United Airlines
Mar 24
FSD7:43 amSioux Falls Joe Foss Field
6h 12m
1 stop
EYW2:55 pmKey West
Apr 1
EYW3:47 pmKey West
7h 02m
1 stop
FSD9:49 pmSioux Falls Joe Foss Field
$456
United Airlines
Mar 3
FSD7:40 amSioux Falls Joe Foss Field
6h 20m
1 stop
EYW3:00 pmKey West
Mar 7
EYW4:05 pmKey West
6h 58m
1 stop
FSD10:03 pmSioux Falls Joe Foss Field
$464
United Airlines
Mar 24
FSD7:43 amSioux Falls Joe Foss Field
6h 12m
1 stop
EYW2:55 pmKey West
Apr 1
EYW3:47 pmKey West
7h 02m
1 stop
FSD9:49 pmSioux Falls Joe Foss Field
$485

momondo Fare Finder

 
Customize your flight search to find flights from Sioux Falls to Key West that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Sioux Falls to Key West that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Tue 5/5

12:29 pm-10:58 pm

2 stops9h 29m

Key West

Tue 5/12

2:29 pm-9:54 pm

1 stop8h 25m

$288

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Tue 3/24

5:44 am-7:12 pm

2 stops12h 28m

Key West

Wed 4/1

2:25 pm-9:40 pm

1 stop8h 15m

$341

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Mon 3/23

5:55 pm-11:30 am

1 stop16h 35m

Key West

Sun 3/29

12:25 pm-5:05 pm

1 stop29h 40m

$342

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Tue 5/5

12:29 pm-10:58 pm

2 stops9h 29m

Key West

Tue 5/12

11:24 am-11:06 pm

2 stops12h 42m

$346

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Mon 3/23

5:55 pm-11:30 am

1 stop16h 35m

Key West

Sun 3/29

12:25 pm-5:05 pm

1 stop29h 40m

$347

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Mon 3/23

5:55 pm-12:21 pm

2 stops17h 26m

Key West

Sun 3/29

12:25 pm-5:05 pm

1 stop29h 40m

$374

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Wed 2/25

6:45 am-7:15 pm

2 stops11h 30m

Key West

Wed 3/4

2:45 pm-9:40 pm

1 stop7h 55m

$379

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Wed 2/25

6:45 am-7:15 pm

2 stops11h 30m

Key West

Wed 3/4

8:04 am-7:10 pm

2 stops12h 06m

$385

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Wed 2/25

5:44 am-7:15 pm

2 stops12h 31m

Key West

Wed 3/4

2:45 pm-9:40 pm

1 stop7h 55m

$394

Sioux FallsKey West

FSD - EYW

FSDEYW

Sioux Falls Joe Foss Field

Wed 2/25

6:45 am-7:15 pm

2 stops11h 30m

Key West

Wed 3/4

12:55 pm-9:40 pm

2 stops9h 45m

$399

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Key West from

How to get the cheapest flight ticket from Sioux Falls to Key West

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Sioux Falls and Key West?

Can stopping save me money on Sioux Falls to Key West flights?

You could potentially save up to 25% on your flight if you consider stops on a Sioux Falls to Key West flight.

When to book flights from Sioux Falls to Key West

Are you open to changing your travel dates? Check out the ideal times to fly from Sioux Falls to Key West according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Sioux Falls to Key West (FSD to EYW) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Sioux Falls to Key West

Fastest flight time

5h 58m

Direct flights

None
The fastest flight from Sioux Falls to Key West takes 5h 58m
There are no direct flights from Sioux Falls to Key West. There are no popular flight routes from Sioux Falls to Key West.
Search flight deals

  • How far is Sioux Falls Joe Foss Field to Key West by plane?

    Sioux Falls Joe Foss Field and Key West are 1559.3 mi apart from one another. A reasonable flight in good conditions will take 5h 58m.

  • When did momondo last update prices for flights from Sioux Falls Joe Foss Field Airport to Key West Airport?

    Prices for flights from Sioux Falls Joe Foss Field Airport to Key West Airport are updated daily.

  • How many operators does momondo search for flights from Sioux Falls Joe Foss Field Airport to Key West Airport?

  • How old do you have to be to fly from Sioux Falls Joe Foss Field Airport to Key West Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Sioux Falls Joe Foss Field Airport to Key West Airport.

  • What documentation or ID do you need to fly to Key West Airport?

    The required travel and health documents for your Key West Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Key West Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Sioux Falls to Key West?

Best airlines flying from Sioux Falls to Key West

Compare and see reviews for airlines that fly from Sioux Falls to Key West with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $288Free CancellationRating
7.2
11,320 reviews
Search American Airlines flights
United AirlinesPriceFrom $490Free CancellationRating
7.4
9,325 reviews
Search United Airlines flights

Traveling to a place near Key West?

Book flights to Key West if you plan to visit one of these locations
Big Pine Key
Little Torch Key

Why use momondo?

Why should I use momondo to find a flight deal from Sioux Falls to Key West?

It is quick and easy to find Sioux Falls to Key West flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Key West that suits you.

Can I find flights from Sioux Falls to Key West with flexible booking policies on momondo?

Yes. All flights to Key West from Sioux Falls on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Sioux Falls to Key West?

Once you have performed a search for Sioux Falls to Key West flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Sioux Falls to Key West right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Key West, momondo offers a useful price alert feature which will track prices for flights to Key West from Sioux Falls and alert you when they change.

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