What airlines fly to South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to South Carolina from Santa Ana, California according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 6 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Santa Ana J. Wayne/Orange Cnty to South Carolina?

Delta, United Airlines, and Southwest are the most popular carriers operating from Santa Ana J. Wayne/Orange Cnty to South Carolina

When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina?

Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina refresh daily.

How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina?

As of October 2026, there are 4 operators available to choose from for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina.

How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$135 Cheap Flights from Santa Ana, California to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Santa Ana, California to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:00 pm - 11:59 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

6h 59m1 stop Atlanta Hartsfield-Jackson

3:14 pm - 9:04 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

8h 50m1 stop Minneapolis St Paul

$357Delta

Tue, Nov 17 - Thu, Dec 3

12:10 pm - 9:58 pmSNA Santa Ana J. Wayne/Orange Cnty-GSP Greenville

6h 48m1 stop Dallas/Fort Worth

7:51 am - 2:03 pmGSP Greenville-SNA Santa Ana J. Wayne/Orange Cnty

9h 12m1 stop Dallas/Fort Worth

$369American Airlines

Sat, Nov 14 - Tue, Nov 17

10:47 am - 8:58 pmSNA Santa Ana J. Wayne/Orange Cnty-GSP Greenville

7h 11m1 stop Chicago O'Hare Intl

4:29 pm - 10:00 pmGSP Greenville-SNA Santa Ana J. Wayne/Orange Cnty

8h 31m1 stop Denver Intl

$369United Airlines

Wed, Nov 11 - Mon, Nov 16

8:00 pm - 10:02 amSNA Santa Ana J. Wayne/Orange Cnty-GSP Greenville

11h 02m2 stops San Francisco Washington, D.C. Dulles Intl

4:29 pm - 9:19 pmGSP Greenville-SNA Santa Ana J. Wayne/Orange Cnty

7h 50m1 stop Denver Intl

$374United Airlines

Wed, Nov 11 - Mon, Nov 16

2:00 pm - 11:59 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

6h 59m1 stop Atlanta Hartsfield-Jackson

3:14 pm - 9:04 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

8h 50m1 stop Minneapolis St Paul

$378Delta

Thu, Nov 19 - Thu, Dec 3

7:45 am - 9:40 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

10h 55m1 stop Dallas Love Field

4:30 pm - 9:05 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

7h 35m1 stop Dallas Love Field

$398Southwest

Thu, Dec 10 - Sun, Dec 13

10:00 am - 9:40 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

8h 40m2 stops Phoenix Sky Harbor Intl Dallas Love Field

4:30 pm - 9:05 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

7h 35m1 stop Dallas Love Field

$398Southwest

Thu, Dec 10 - Sun, Dec 13

6:45 am - 6:53 pmSNA Santa Ana J. Wayne/Orange Cnty-CAE Columbia Metropolitan

9h 08m1 stop Dallas/Fort Worth

6:37 am - 10:56 amCAE Columbia Metropolitan-SNA Santa Ana J. Wayne/Orange Cnty

7h 19m1 stop Dallas/Fort Worth

$399American Airlines

Fri, Feb 26 - Mon, Mar 1

7:30 am - 10:10 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

11h 40m2 stops Las Vegas Harry Reid Intl Akron/Canton

7:00 am - 5:40 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

13h 40m2 stops Fort Myers SW Florida Intl Las Vegas Harry Reid Intl

$451Breeze Airways

Tue, Nov 10 - Sat, Nov 14

7:30 am - 11:42 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

13h 12m2 stops Las Vegas Harry Reid Intl Syracuse Hancock Intl

7:05 am - 3:03 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

10h 58m2 stops Akron/Canton Las Vegas Harry Reid Intl

$469Breeze Airways

Fri, Nov 13 - Tue, Nov 17

Cheap last minute flights

Enter your travel dates to find the best prices.

8:00 pm - 9:47 amSNA Santa Ana J. Wayne/Orange Cnty-CAE Columbia Metropolitan

10h 47m2 stops San Francisco Washington, D.C. Dulles Intl

2:52 pm - 8:28 pmCAE Columbia Metropolitan-SNA Santa Ana J. Wayne/Orange Cnty

8h 36m1 stop Washington, D.C. Dulles Intl

$584United Airlines

Fri, Oct 23 - Mon, Oct 26

8:00 pm - 9:47 amSNA Santa Ana J. Wayne/Orange Cnty-CAE Columbia Metropolitan

10h 47m2 stops San Francisco Washington, D.C. Dulles Intl

2:52 pm - 10:00 pmCAE Columbia Metropolitan-SNA Santa Ana J. Wayne/Orange Cnty

10h 08m2 stops Washington, D.C. Dulles Intl Denver Intl

$589United Airlines

Fri, Oct 23 - Mon, Oct 26

7:15 am - 5:38 pmSNA Santa Ana J. Wayne/Orange Cnty-HHH Hilton Head Island

7h 23m1 stop Charlotte Douglas

1:50 pm - 9:13 pmHHH Hilton Head Island-SNA Santa Ana J. Wayne/Orange Cnty

10h 23m1 stop Chicago O'Hare Intl

$595American Airlines

Wed, Oct 21 - Sat, Oct 24

7:31 pm - 11:05 amSNA Santa Ana J. Wayne/Orange Cnty-HHH Hilton Head Island

12h 34m2 stops Phoenix Sky Harbor Intl Charlotte Douglas

1:50 pm - 9:13 pmHHH Hilton Head Island-SNA Santa Ana J. Wayne/Orange Cnty

10h 23m1 stop Chicago O'Hare Intl

$600American Airlines

Wed, Oct 21 - Sat, Oct 24

7:31 pm - 11:05 amSNA Santa Ana J. Wayne/Orange Cnty-HHH Hilton Head Island

12h 34m2 stops Phoenix Sky Harbor Intl Charlotte Douglas

2:56 pm - 10:29 pmHHH Hilton Head Island-SNA Santa Ana J. Wayne/Orange Cnty

10h 33m2 stops Charlotte Douglas Dallas/Fort Worth

$629American Airlines

Wed, Oct 21 - Sat, Oct 24

6:22 pm - 9:47 amSNA Santa Ana J. Wayne/Orange Cnty-CAE Columbia Metropolitan

12h 25m2 stops San Francisco Washington, D.C. Dulles Intl

6:15 am - 11:37 amCAE Columbia Metropolitan-SNA Santa Ana J. Wayne/Orange Cnty

8h 22m1 stop Chicago O'Hare Intl

$693United Airlines

Fri, Oct 23 - Sun, Oct 25

10:35 am - 9:35 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

8h 00m2 stops Las Vegas Harry Reid Intl Nashville Intl

6:25 am - 1:00 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

9h 35m2 stops Nashville Intl Denver Intl

$878Southwest

Thu, Oct 22 - Sun, Oct 25

11:32 am - 9:23 pmSNA Santa Ana J. Wayne/Orange Cnty-CAE Columbia Metropolitan

6h 51m1 stop Atlanta Hartsfield-Jackson

5:59 pm - 10:12 pmCAE Columbia Metropolitan-SNA Santa Ana J. Wayne/Orange Cnty

7h 13m1 stop Atlanta Hartsfield-Jackson

$983Delta

Sun, Oct 25 - Sun, Nov 8

7:30 am - 11:42 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

13h 12m2 stops Las Vegas Harry Reid Intl Syracuse Hancock Intl

7:05 am - 3:43 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

11h 38m2 stops Akron/Canton Las Vegas Harry Reid Intl

$989Breeze Airways

Fri, Oct 23 - Sun, Oct 25

7:30 am - 11:42 pmSNA Santa Ana J. Wayne/Orange Cnty-CHS Charleston

13h 12m2 stops Las Vegas Harry Reid Intl Syracuse Hancock Intl

6:45 am - 9:28 pmCHS Charleston-SNA Santa Ana J. Wayne/Orange Cnty

41h 43m3 stops Columbus Raleigh-Durham Provo

$1,248Breeze Airways

Fri, Oct 23 - Sun, Oct 25

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Delta flights from Santa Ana, California to South Carolina

Our best Delta deals on Santa Ana, California to South Carolina flight tickets

Delta

Nov 17

SNA2:00 pmSanta Ana J. Wayne/Orange Cnty

6h 59m

1 stop

CHS11:59 pmCharleston

Dec 3

CHS3:14 pmCharleston

8h 50m

1 stop

SNA9:04 pmSanta Ana J. Wayne/Orange Cnty

$357

Delta

Nov 19

SNA2:00 pmSanta Ana J. Wayne/Orange Cnty

6h 59m

1 stop

CHS11:59 pmCharleston

Dec 3

CHS3:14 pmCharleston

8h 50m

1 stop

SNA9:04 pmSanta Ana J. Wayne/Orange Cnty

$378

Delta

Dec 14

SNA2:30 pmSanta Ana J. Wayne/Orange Cnty

6h 17m

1 stop

GSP11:47 pmGreenville

Jan 4

GSP3:42 pmGreenville

9h 57m

1 stop

SNA10:39 pmSanta Ana J. Wayne/Orange Cnty

$397

Alaska Airlines flights from Santa Ana, California to South Carolina

Our best Alaska Airlines deals on Santa Ana, California to South Carolina flight tickets

Alaska Airlines

Nov 5

SNA8:19 amSanta Ana J. Wayne/Orange Cnty

29h 36m

1 stop

CHS4:55 pmCharleston

Nov 9

CHS5:58 pmCharleston

19h 00m

1 stop

SNA9:58 amSanta Ana J. Wayne/Orange Cnty

$567

Alaska Airlines

Oct 30

SNA8:07 amSanta Ana J. Wayne/Orange Cnty

11h 53m

2 stops

GSP11:00 pmGreenville

Nov 3

GSP11:39 amGreenville

13h 47m

2 stops

SNA10:26 pmSanta Ana J. Wayne/Orange Cnty

$757

Alaska Airlines

Oct 26

SNA3:13 pmSanta Ana J. Wayne/Orange Cnty

16h 55m

2 stops

GSP11:08 amGreenville

Oct 29

GSP1:58 pmGreenville

22h 31m

2 stops

SNA9:29 amSanta Ana J. Wayne/Orange Cnty

$923

momondo Fare Finder

Use the filters below to find and compare flights from Santa Ana, California to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Santa AnaCharleston

SNA Santa Ana J. Wayne/Orange Cnty - CHS Charleston

SNACHS

Santa Ana J. Wayne/Orange Cnty

Tue 11/17

2:00 pm-11:59 pm

1 stop6h 59m

Charleston

Thu 12/3

3:14 pm-9:04 pm

1 stop8h 50m

$357

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Sat 11/14

12:10 pm-9:58 pm

1 stop6h 48m

Greenville

Tue 11/17

7:51 am-2:03 pm

1 stop9h 12m

$369

Quickest round-trip

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 11/11

10:47 am-8:58 pm

1 stop7h 11m

Greenville

Mon 11/16

4:29 pm-10:00 pm

1 stop8h 31m

$369

Santa AnaGreenville

SNA Santa Ana J. Wayne/Orange Cnty - GSP Greenville

SNAGSP

Santa Ana J. Wayne/Orange Cnty

Wed 11/11

8:00 pm-10:02 am

2 stops11h 02m

Greenville

Mon 11/16

4:29 pm-9:19 pm

1 stop7h 50m

$374

Santa AnaCharleston

SNA Santa Ana J. Wayne/Orange Cnty - CHS Charleston

SNACHS

Santa Ana J. Wayne/Orange Cnty

Thu 11/19

2:00 pm-11:59 pm

1 stop6h 59m

Charleston

Thu 12/3

3:14 pm-9:04 pm

1 stop8h 50m

$378

Santa AnaCharleston

SNA Santa Ana J. Wayne/Orange Cnty - CHS Charleston

SNACHS

Santa Ana J. Wayne/Orange Cnty

Thu 12/10

7:45 am-9:40 pm

1 stop10h 55m

Charleston

Sun 12/13

4:30 pm-9:05 pm

1 stop7h 35m

$398

Santa AnaCharleston

SNA Santa Ana J. Wayne/Orange Cnty - CHS Charleston

SNACHS

Santa Ana J. Wayne/Orange Cnty

Thu 12/10

10:00 am-9:40 pm

2 stops8h 40m

Charleston

Sun 12/13

4:30 pm-9:05 pm

1 stop7h 35m

$398

Santa AnaColumbia

SNA Santa Ana J. Wayne/Orange Cnty - CAE Columbia Metropolitan

SNACAE

Santa Ana J. Wayne/Orange Cnty

Fri 2/26

6:45 am-6:53 pm

1 stop9h 08m

Columbia Metropolitan

Mon 3/1

6:37 am-10:56 am

1 stop7h 19m

$399

Santa AnaCharleston

SNA Santa Ana J. Wayne/Orange Cnty - CHS Charleston

SNACHS

Santa Ana J. Wayne/Orange Cnty

Tue 11/10

7:30 am-10:10 pm

2 stops11h 40m

Charleston

Sat 11/14

7:00 am-5:40 pm

2 stops13h 40m

$451

Santa AnaCharleston

SNA Santa Ana J. Wayne/Orange Cnty - CHS Charleston

SNACHS

Santa Ana J. Wayne/Orange Cnty

Fri 11/13

7:30 am-11:42 pm

2 stops13h 12m

Charleston

Tue 11/17

7:05 am-3:03 pm

2 stops10h 58m

$469

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Santa Ana, California to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Santa Ana, California is in February. Flight prices, which tend to average around $452, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to South Carolina from Santa Ana, California during January instead. Flights to South Carolina in January, while not as cheap as those in February, still average around $466.

Can stopping save me money on Santa Ana, California to South Carolina flights?

You could potentially save up to 29% on your flight if you consider stops on a Santa Ana, California to South Carolina flight.

Cheap Santa Ana, California to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Santa Ana, California to South Carolina

Best Price Found	$135
Fastest flight time	4h 37m
Direct flights	None

The best one-way flight to South Carolina from Santa Ana, California in the past 72 hours is $135. The best round-trip flight deal from Santa Ana, California to South Carolina found on momondo in the last 72 hours is $357.

The fastest flight from Santa Ana, California to South Carolina takes 4h 37m

There are no direct flights from Santa Ana, California to South Carolina. There are no popular flight routes from Santa Ana, California to South Carolina.

Search flight deals

Frequently asked questions about flying from Santa Ana, California to South Carolina

When did momondo last update prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina?
Prices for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina refresh daily.
How many operators does momondo search for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina?
As of October 2026, there are 4 operators available to choose from for flights from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina.
How old do you have to be to fly from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Santa Ana J. Wayne/Orange Cnty Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Santa Ana, California to South Carolina

Compare and see reviews for airlines that fly from Santa Ana, California to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $308	Free Cancellation	Rating 7.0 12,172 reviews	Search American Airlines flights
Delta	PriceFrom $377	Free Cancellation	Rating 7.8 8,653 reviews	Search Delta flights
United Airlines	PriceFrom $378	Free Cancellation	Rating 7.3 10,387 reviews	Search United Airlines flights
Southwest	PriceFrom $381	Free Cancellation	Rating 7.9 4,209 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Santa Ana to South Carolina?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Santa Ana to South Carolina. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Santa Ana to South Carolina with flexible booking policies on momondo?

Flights from Santa Ana to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Santa Ana to South Carolina?

momondo helps you find the best flight between Santa Ana and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Santa Ana to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Santa Ana to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.