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Cheap flights from Rochester, Minnesota to Knoxville from $283

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Rochester, Minnesota to Knoxville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Rochester, Minnesota to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:53 am - 10:48 am
RST
-
TYS
3h 55m
1 stop
American Airlines Logo
7:50 am - 11:06 am
TYS
-
RST
4h 16m
1 stop
$328American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
5:53 am - 10:48 am
RST
-
TYS
3h 55m
1 stop
American Airlines Logo
8:00 am - 6:13 pm
TYS
-
RST
11h 13m
2 stops
$334American Airlines
Sat, Apr 4 - Wed, Apr 8
American Airlines Logo
4:39 pm - 11:50 pm
RST
-
TYS
6h 11m
2 stops
American Airlines Logo
5:00 am - 11:06 am
TYS
-
RST
7h 06m
2 stops
$339American Airlines
Sat, Apr 4 - Wed, Apr 8
United Airlines Logo
11:28 am - 4:59 pm
RST
-
TYS
4h 31m
1 stop
United Airlines Logo
5:57 pm - 9:32 pm
TYS
-
RST
4h 35m
1 stop
$512United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
6:50 pm - 10:36 am
RST
-
TYS
14h 46m
2 stops
United Airlines Logo
5:57 pm - 9:32 pm
TYS
-
RST
4h 35m
1 stop
$586United Airlines
Sat, Aug 22 - Wed, Aug 26
American Airlines Logo
5:53 am - 10:48 am
RST
-
TYS
3h 55m
1 stop
American Airlines Logo
7:40 am - 11:02 am
TYS
-
RST
4h 22m
1 stop
$639American Airlines
Thu, Apr 2 - Sun, Apr 5
American Airlines Logo
5:53 am - 6:13 pm
RST
-
TYS
11h 20m
2 stops
American Airlines Logo
7:40 am - 11:02 am
TYS
-
RST
4h 22m
1 stop
$644American Airlines
Thu, Apr 2 - Sun, Apr 5
American Airlines Logo
5:53 am - 5:31 pm
RST
-
TYS
10h 38m
2 stops
American Airlines Logo
7:40 am - 11:02 am
TYS
-
RST
4h 22m
1 stop
$687American Airlines
Wed, Apr 1 - Sun, Apr 5
American Airlines Logo
5:53 am - 5:31 pm
RST
-
TYS
10h 38m
2 stops
American Airlines Logo
9:25 am - 6:01 pm
TYS
-
RST
9h 36m
2 stops
$692American Airlines
Wed, Apr 1 - Sun, Apr 5
United Airlines Logo
6:50 pm - 10:36 am
RST
-
TYS
14h 46m
2 stops
United Airlines Logo
5:45 am - 5:37 pm
TYS
-
RST
12h 52m
2 stops
$694United Airlines
Sat, Aug 22 - Wed, Aug 26

United Airlines flights from Rochester, Minnesota to Knoxville

Our best United Airlines deals on Rochester, Minnesota to Knoxville flight tickets
United Airlines
Aug 22
RST11:28 amRochester
4h 31m
1 stop
TYS4:59 pmKnoxville McGhee Tyson
Aug 26
TYS5:57 pmKnoxville McGhee Tyson
4h 35m
1 stop
RST9:32 pmRochester
$512
United Airlines
Aug 22
RST6:50 pmRochester
14h 46m
2 stops
TYS10:36 amKnoxville McGhee Tyson
Aug 26
TYS5:57 pmKnoxville McGhee Tyson
4h 35m
1 stop
RST9:32 pmRochester
$586
United Airlines
Aug 22
RST6:50 pmRochester
14h 46m
2 stops
TYS10:36 amKnoxville McGhee Tyson
Aug 26
TYS5:45 amKnoxville McGhee Tyson
12h 52m
2 stops
RST5:37 pmRochester
$694

American Airlines flights from Rochester, Minnesota to Knoxville

Our best American Airlines deals on Rochester, Minnesota to Knoxville flight tickets
American Airlines
Apr 4
RST5:53 amRochester
3h 55m
1 stop
TYS10:48 amKnoxville McGhee Tyson
Apr 8
TYS7:50 amKnoxville McGhee Tyson
4h 16m
1 stop
RST11:06 amRochester
$328
American Airlines
Apr 4
RST5:53 amRochester
3h 55m
1 stop
TYS10:48 amKnoxville McGhee Tyson
Apr 8
TYS8:00 amKnoxville McGhee Tyson
11h 13m
2 stops
RST6:13 pmRochester
$334
American Airlines
Apr 4
RST4:39 pmRochester
6h 11m
2 stops
TYS11:50 pmKnoxville McGhee Tyson
Apr 8
TYS5:00 amKnoxville McGhee Tyson
7h 06m
2 stops
RST11:06 amRochester
$339

momondo Fare Finder

 
Customize your flight search to find flights from Rochester, Minnesota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 21, 2026.
Use the filters below to find and compare flights from Rochester, Minnesota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 4/4

5:53 am-10:48 am

1 stop3h 55m

Knoxville McGhee Tyson

Wed 4/8

7:50 am-11:06 am

1 stop4h 16m

$328

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 4/4

5:53 am-10:48 am

1 stop3h 55m

Knoxville McGhee Tyson

Wed 4/8

8:00 am-6:13 pm

2 stops11h 13m

$334

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 4/4

4:39 pm-11:50 pm

2 stops6h 11m

Knoxville McGhee Tyson

Wed 4/8

5:00 am-11:06 am

2 stops7h 06m

$339

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 8/22

11:28 am-4:59 pm

1 stop4h 31m

Knoxville McGhee Tyson

Wed 8/26

5:57 pm-9:32 pm

1 stop4h 35m

$512

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 8/22

6:50 pm-10:36 am

2 stops14h 46m

Knoxville McGhee Tyson

Wed 8/26

5:57 pm-9:32 pm

1 stop4h 35m

$586

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 4/2

5:53 am-10:48 am

1 stop3h 55m

Knoxville McGhee Tyson

Sun 4/5

7:40 am-11:02 am

1 stop4h 22m

$639

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 4/2

5:53 am-6:13 pm

2 stops11h 20m

Knoxville McGhee Tyson

Sun 4/5

7:40 am-11:02 am

1 stop4h 22m

$644

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Wed 4/1

5:53 am-5:31 pm

2 stops10h 38m

Knoxville McGhee Tyson

Sun 4/5

7:40 am-11:02 am

1 stop4h 22m

$687

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Wed 4/1

5:53 am-5:31 pm

2 stops10h 38m

Knoxville McGhee Tyson

Sun 4/5

9:25 am-6:01 pm

2 stops9h 36m

$692

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 8/22

6:50 pm-10:36 am

2 stops14h 46m

Knoxville McGhee Tyson

Wed 8/26

5:45 am-5:37 pm

2 stops12h 52m

$694

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Rochester, Minnesota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Rochester, Minnesota to Knoxville flights?

You could potentially save up to 57% on your flight if you consider stops on a Rochester, Minnesota to Knoxville flight.

When to book flights from Rochester, Minnesota to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Rochester, Minnesota to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Rochester, Minnesota to Knoxville (RST to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Rochester, Minnesota to Knoxville

Fastest flight time

6h 24m

Direct flights

None
The fastest flight from Rochester, Minnesota to Knoxville takes 6h 24m
There are no direct flights from Rochester, Minnesota to Knoxville. There are no popular flight routes from Rochester, Minnesota to Knoxville.
Search flight deals

  • How far is Rochester to Knoxville McGhee Tyson by plane?

    There are 715.7 mi between Rochester and Knoxville McGhee Tyson. 6h 24m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Rochester Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Rochester Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Rochester Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Rochester Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Rochester Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Rochester, Minnesota to Knoxville?

Best airlines flying from Rochester, Minnesota to Knoxville

Compare and see reviews for airlines that fly from Rochester, Minnesota to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $314Free CancellationRating
7.1
11,488 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Rochester to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Rochester.

Can I find flights from Rochester to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Rochester on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Rochester to Knoxville?

Once all potential Rochester to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Rochester to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Rochester. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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