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Cheap flights from Rochester, Minnesota to Knoxville from $263

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Rochester, Minnesota to Knoxville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Rochester, Minnesota to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
4:44 pm - 11:01 pm
RST
-
TYS
5h 17m
1 stop
Delta Logo
6:45 am - 10:54 am
TYS
-
RST
5h 09m
1 stop
$298Delta
Thu, Jul 23 - Mon, Jul 27
Delta Logo
4:44 pm - 11:01 pm
RST
-
TYS
5h 17m
1 stop
Delta Logo
11:55 am - 10:42 pm
TYS
-
RST
11h 47m
2 stops
$304Delta
Thu, Jul 23 - Mon, Jul 27
Delta Logo
11:34 am - 9:38 pm
RST
-
TYS
9h 04m
2 stops
Delta Logo
5:40 am - 10:54 am
TYS
-
RST
6h 14m
2 stops
$309Delta
Thu, Jul 23 - Mon, Jul 27
Delta Logo
11:34 am - 11:52 pm
RST
-
TYS
11h 18m
2 stops
Delta Logo
11:55 am - 10:42 pm
TYS
-
RST
11h 47m
2 stops
$324Delta
Thu, Jul 23 - Mon, Jul 27
American Airlines Logo
5:45 am - 10:57 am
RST
-
TYS
4h 12m
1 stop
American Airlines Logo
6:07 pm - 12:05 am
TYS
-
RST
6h 58m
2 stops
$334American Airlines
Tue, May 19 - Sat, May 23
Delta Logo
5:30 am - 1:10 pm
RST
-
TYS
6h 40m
2 stops
Delta Logo
5:40 am - 10:53 am
TYS
-
RST
6h 13m
2 stops
$339Delta
Tue, May 19 - Sat, May 23
Delta Logo
4:45 pm - 10:57 pm
RST
-
TYS
5h 12m
1 stop
Delta Logo
5:40 am - 10:53 am
TYS
-
RST
6h 13m
2 stops
$349Delta
Sat, May 23 - Tue, May 26
Delta Logo
11:33 am - 12:01 am
RST
-
TYS
11h 28m
2 stops
Delta Logo
5:40 am - 10:53 am
TYS
-
RST
6h 13m
2 stops
$354Delta
Sat, May 23 - Tue, May 26
American Airlines Logo
5:45 am - 10:57 am
RST
-
TYS
4h 12m
1 stop
American Airlines Logo
1:12 pm - 6:12 pm
TYS
-
RST
6h 00m
1 stop
$388American Airlines
Tue, May 19 - Sat, May 23
American Airlines Logo
5:38 am - 12:54 pm
RST
-
TYS
6h 16m
1 stop
American Airlines Logo
6:07 pm - 11:59 pm
TYS
-
RST
6h 52m
2 stops
$406American Airlines
Wed, Jun 3 - Wed, Jun 10

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Delta flights from Rochester, Minnesota to Knoxville

Our best Delta deals on Rochester, Minnesota to Knoxville flight tickets
Delta
Jul 23
RST4:44 pmRochester
5h 17m
1 stop
TYS11:01 pmKnoxville McGhee Tyson
Jul 27
TYS6:45 amKnoxville McGhee Tyson
5h 09m
1 stop
RST10:54 amRochester
$298
Delta
Jul 23
RST4:44 pmRochester
5h 17m
1 stop
TYS11:01 pmKnoxville McGhee Tyson
Jul 27
TYS5:40 amKnoxville McGhee Tyson
6h 14m
2 stops
RST10:54 amRochester
$304
Delta
Jul 23
RST11:34 amRochester
9h 04m
2 stops
TYS9:38 pmKnoxville McGhee Tyson
Jul 27
TYS5:40 amKnoxville McGhee Tyson
6h 14m
2 stops
RST10:54 amRochester
$309

American Airlines flights from Rochester, Minnesota to Knoxville

Our best American Airlines deals on Rochester, Minnesota to Knoxville flight tickets
American Airlines
May 19
RST5:45 amRochester
4h 12m
1 stop
TYS10:57 amKnoxville McGhee Tyson
May 23
TYS6:07 pmKnoxville McGhee Tyson
6h 58m
2 stops
RST12:05 amRochester
$334
American Airlines
May 19
RST5:45 amRochester
4h 12m
1 stop
TYS10:57 amKnoxville McGhee Tyson
May 23
TYS1:12 pmKnoxville McGhee Tyson
6h 00m
1 stop
RST6:12 pmRochester
$388
American Airlines
Jun 3
RST5:38 amRochester
6h 16m
1 stop
TYS12:54 pmKnoxville McGhee Tyson
Jun 10
TYS6:07 pmKnoxville McGhee Tyson
6h 52m
2 stops
RST11:59 pmRochester
$406

momondo Fare Finder

 
Customize your flight search to find flights from Rochester, Minnesota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Rochester, Minnesota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 7/23

4:44 pm-11:01 pm

1 stop5h 17m

Knoxville McGhee Tyson

Mon 7/27

6:45 am-10:54 am

1 stop5h 09m

$298

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 7/23

4:44 pm-11:01 pm

1 stop5h 17m

Knoxville McGhee Tyson

Mon 7/27

11:55 am-10:42 pm

2 stops11h 47m

$304

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 7/23

11:34 am-9:38 pm

2 stops9h 04m

Knoxville McGhee Tyson

Mon 7/27

5:40 am-10:54 am

2 stops6h 14m

$309

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 7/23

11:34 am-11:52 pm

2 stops11h 18m

Knoxville McGhee Tyson

Mon 7/27

11:55 am-10:42 pm

2 stops11h 47m

$324

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Tue 5/19

5:45 am-10:57 am

1 stop4h 12m

Knoxville McGhee Tyson

Sat 5/23

6:07 pm-12:05 am

2 stops6h 58m

$334

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Tue 5/19

5:30 am-1:10 pm

2 stops6h 40m

Knoxville McGhee Tyson

Sat 5/23

5:40 am-10:53 am

2 stops6h 13m

$339

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 5/23

4:45 pm-10:57 pm

1 stop5h 12m

Knoxville McGhee Tyson

Tue 5/26

5:40 am-10:53 am

2 stops6h 13m

$349

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 5/23

11:33 am-12:01 am

2 stops11h 28m

Knoxville McGhee Tyson

Tue 5/26

5:40 am-10:53 am

2 stops6h 13m

$354
Quickest round-trip

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Tue 5/19

5:45 am-10:57 am

1 stop4h 12m

Knoxville McGhee Tyson

Sat 5/23

1:12 pm-6:12 pm

1 stop6h 00m

$388

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Wed 6/3

5:38 am-12:54 pm

1 stop6h 16m

Knoxville McGhee Tyson

Wed 6/10

6:07 pm-11:59 pm

2 stops6h 52m

$406

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Rochester, Minnesota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Rochester, Minnesota to Knoxville flights?

You could potentially save up to 46% on your flight if you consider stops on a Rochester, Minnesota to Knoxville flight.

When to book flights from Rochester, Minnesota to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Rochester, Minnesota to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Rochester, Minnesota to Knoxville (RST to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Rochester, Minnesota to Knoxville

Fastest flight time

5h 12m

Direct flights

None
The fastest flight from Rochester, Minnesota to Knoxville takes 5h 12m
There are no direct flights from Rochester, Minnesota to Knoxville. There are no popular flight routes from Rochester, Minnesota to Knoxville.
Search flight deals

Frequently asked questions about flying from Rochester, Minnesota to Knoxville

  • How far is Rochester to Knoxville McGhee Tyson by plane?

    There are 715.7 mi between Rochester and Knoxville McGhee Tyson. 5h 12m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Rochester Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Rochester Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Rochester Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Rochester Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Rochester Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Rochester, Minnesota to Knoxville?

Best airlines flying from Rochester, Minnesota to Knoxville

Compare and see reviews for airlines that fly from Rochester, Minnesota to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $314Free CancellationRating
7.1
11,666 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Rochester to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Rochester.

Can I find flights from Rochester to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Rochester on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Rochester to Knoxville?

Once all potential Rochester to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Rochester to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Rochester. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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