Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Rochester, Minnesota to Knoxville from $259

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Rochester, Minnesota to Knoxville departing on 4/11. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Rochester, Minnesota to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
11:15 am - 9:32 pmRST-TYS
9h 17m2 stops
Delta Logo
6:45 am - 10:46 amTYS-RST
5h 01m1 stop
$259Delta
Find Deal
Sat, Apr 11 - Wed, Apr 15
Delta Logo
11:15 am - 9:32 pmRST-TYS
9h 17m2 stops
Delta Logo
7:30 am - 4:02 pmTYS-RST
9h 32m2 stops
$279Delta
Find Deal
Sat, Apr 11 - Wed, Apr 15
Delta Logo
6:15 pm - 11:09 pmRST-TYS
3h 54m1 stop
Delta Logo
6:32 am - 11:00 amTYS-RST
5h 28m1 stop
$348Delta
Find Deal
Fri, Nov 21 - Thu, Dec 4
Delta Logo
6:15 pm - 11:09 pmRST-TYS
3h 54m1 stop
Delta Logo
5:40 am - 11:00 amTYS-RST
6h 20m2 stops
$354Delta
Find Deal
Fri, Nov 21 - Thu, Dec 4
Delta Logo
6:15 pm - 11:09 pmRST-TYS
3h 54m1 stop
Delta Logo
6:35 am - 10:55 amTYS-RST
5h 20m1 stop
$363Delta
Find Deal
Thu, Nov 20 - Mon, Nov 24
Delta Logo
11:35 am - 11:41 pmRST-TYS
11h 06m2 stops
Delta Logo
6:35 am - 10:55 amTYS-RST
5h 20m1 stop
$369Delta
Find Deal
Thu, Nov 20 - Mon, Nov 24
Delta Logo
11:35 am - 11:41 pmRST-TYS
11h 06m2 stops
Delta Logo
5:35 am - 10:55 amTYS-RST
6h 20m2 stops
$374Delta
Find Deal
Thu, Nov 20 - Mon, Nov 24
Delta Logo
11:15 am - 9:32 pmRST-TYS
9h 17m2 stops
Delta Logo
6:45 am - 10:46 amTYS-RST
5h 01m1 stop
$384Delta
Find Deal
Sat, Apr 11 - Wed, Apr 15
American Airlines Logo
6:03 am - 3:49 pmRST-TYS
8h 46m2 stops
American Airlines Logo
4:59 pm - 11:59 pmTYS-RST
8h 00m2 stops
$509American Airlines
Find Deal
Fri, Nov 21 - Thu, Dec 4
American Airlines Logo
6:03 am - 3:49 pmRST-TYS
8h 46m2 stops
American Airlines Logo
4:59 pm - 11:59 pmTYS-RST
8h 00m2 stops
$578American Airlines
Find Deal
Fri, Nov 21 - Thu, Dec 4

Delta flights from Rochester, Minnesota to Knoxville

Our best Delta deals on Rochester, Minnesota to Knoxville flight tickets
Delta
Apr 11
RST11:15 amRochester
9h 17m
2 stops
TYS9:32 pmKnoxville McGhee Tyson
Apr 15
TYS6:45 amKnoxville McGhee Tyson
5h 01m
1 stop
RST10:46 amRochester
$259
Find similar
Delta
Apr 11
RST11:15 amRochester
9h 17m
2 stops
TYS9:32 pmKnoxville McGhee Tyson
Apr 15
TYS7:30 amKnoxville McGhee Tyson
9h 32m
2 stops
RST4:02 pmRochester
$279
Find similar
Delta
Nov 21
RST6:15 pmRochester
3h 54m
1 stop
TYS11:09 pmKnoxville McGhee Tyson
Dec 4
TYS6:32 amKnoxville McGhee Tyson
5h 28m
1 stop
RST11:00 amRochester
$348
Find similar

American Airlines flights from Rochester, Minnesota to Knoxville

Our best American Airlines deals on Rochester, Minnesota to Knoxville flight tickets
American Airlines
Nov 21
RST6:03 amRochester
8h 46m
2 stops
TYS3:49 pmKnoxville McGhee Tyson
Dec 4
TYS4:59 pmKnoxville McGhee Tyson
8h 00m
2 stops
RST11:59 pmRochester
$509
Find similar
American Airlines
Nov 21
RST6:03 amRochester
8h 46m
2 stops
TYS3:49 pmKnoxville McGhee Tyson
Dec 4
TYS4:59 pmKnoxville McGhee Tyson
8h 00m
2 stops
RST11:59 pmRochester
$578
Find similar
American Airlines
Nov 21
RST6:03 amRochester
8h 45m
2 stops
TYS3:48 pmKnoxville McGhee Tyson
Nov 25
TYS5:05 amKnoxville McGhee Tyson
7h 12m
2 stops
RST11:17 amRochester
$629
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Rochester, Minnesota to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Rochester, Minnesota to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 4/11

11:15 am-9:32 pm

2 stops9h 17m

Knoxville McGhee Tyson

Wed 4/15

6:45 am-10:46 am

1 stop5h 01m

$259

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 4/11

11:15 am-9:32 pm

2 stops9h 17m

Knoxville McGhee Tyson

Wed 4/15

7:30 am-4:02 pm

2 stops9h 32m

$279

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Fri 11/21

6:15 pm-11:09 pm

1 stop3h 54m

Knoxville McGhee Tyson

Thu 12/4

6:32 am-11:00 am

1 stop5h 28m

$348

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Fri 11/21

6:15 pm-11:09 pm

1 stop3h 54m

Knoxville McGhee Tyson

Thu 12/4

5:40 am-11:00 am

2 stops6h 20m

$354

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 11/20

6:15 pm-11:09 pm

1 stop3h 54m

Knoxville McGhee Tyson

Mon 11/24

6:35 am-10:55 am

1 stop5h 20m

$363

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 11/20

11:35 am-11:41 pm

2 stops11h 06m

Knoxville McGhee Tyson

Mon 11/24

6:35 am-10:55 am

1 stop5h 20m

$369

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Thu 11/20

11:35 am-11:41 pm

2 stops11h 06m

Knoxville McGhee Tyson

Mon 11/24

5:35 am-10:55 am

2 stops6h 20m

$374

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Sat 4/11

11:15 am-9:32 pm

2 stops9h 17m

Knoxville McGhee Tyson

Wed 4/15

6:45 am-10:46 am

1 stop5h 01m

$384

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Fri 11/21

6:03 am-3:49 pm

2 stops8h 46m

Knoxville McGhee Tyson

Thu 12/4

4:59 pm-11:59 pm

2 stops8h 00m

$509

RochesterKnoxville

RST - TYS

RSTTYS

Rochester

Fri 11/21

6:03 am-3:49 pm

2 stops8h 46m

Knoxville McGhee Tyson

Thu 12/4

4:59 pm-11:59 pm

2 stops8h 00m

$578

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Rochester, Minnesota to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Rochester, Minnesota to Knoxville is on a Monday. Travelers who choose to depart for Knoxville on a Monday will often find tickets for as low as $390. When flying out on a Friday, the most expensive travel day of the week, you can expect to see flight prices from Rochester, Minnesota to Knoxville for around $657.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Rochester, Minnesota to Knoxville when you can find flight prices for as low as $503. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $565.

Can stopping save me money on Rochester, Minnesota to Knoxville flights?

You could potentially save up to 36% on your flight if you consider stops on a Rochester, Minnesota to Knoxville flight.

When to book flights from Rochester, Minnesota to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Rochester, Minnesota to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Rochester, Minnesota to Knoxville (RST to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Rochester, Minnesota to Knoxville

Direct flights

None
There are no direct flights from Rochester, Minnesota to Knoxville. There are no popular flight routes from Rochester, Minnesota to Knoxville.
Search flight deals

  • How far is Rochester to Knoxville McGhee Tyson by plane?

    There are 715.7 mi between Rochester and Knoxville McGhee Tyson. 3h 54m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Rochester Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Rochester Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Rochester Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Rochester Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Rochester Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Rochester, Minnesota to Knoxville?

Best airlines flying from Rochester, Minnesota to Knoxville

Compare and see reviews for airlines that fly from Rochester, Minnesota to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $368Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Rochester to Knoxville?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Knoxville from Rochester.

Can I find flights from Rochester to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Rochester on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Rochester to Knoxville?

Once all potential Rochester to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Rochester to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Rochester. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 12/6
Sat 12/13
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States