Cheap flights from Roanoke to South Carolina from $221

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Roanoke to South Carolina departing on 8/27. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Roanoke to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:36 pm - 8:38 am
ROA
-
CHS
18h 02m
1 stop
Multiple Airlines Logo
2:53 pm - 2:05 pm
CHS
-
ROA
23h 12m
1 stop
$224Multiple Airlines
Mon, Aug 24 - Thu, Aug 27
Delta Logo
6:40 pm - 11:57 pm
ROA
-
CHS
5h 17m
1 stop
Delta Logo
6:40 am - 10:31 am
CHS
-
ROA
3h 51m
1 stop
$261Delta
Tue, Sep 15 - Wed, Sep 30
Delta Logo
3:30 pm - 10:09 pm
ROA
-
CHS
6h 39m
1 stop
Delta Logo
5:25 am - 10:31 am
CHS
-
ROA
5h 06m
1 stop
$275Delta
Fri, Sep 18 - Wed, Sep 30
Delta Logo
7:57 pm - 12:26 am
ROA
-
CHS
4h 29m
1 stop
Delta Logo
7:59 pm - 12:25 am
CHS
-
ROA
4h 26m
1 stop
$289Delta
Thu, Jul 23 - Sun, Jul 26
Delta Logo
6:00 am - 10:06 am
ROA
-
CHS
4h 06m
1 stop
Delta Logo
5:33 pm - 11:59 pm
CHS
-
ROA
6h 26m
1 stop
$290Delta
Thu, Sep 17 - Tue, Sep 29
Multiple Airlines Logo
2:36 pm - 8:38 am
ROA
-
CHS
18h 02m
1 stop
Multiple Airlines Logo
4:51 pm - 2:05 pm
CHS
-
ROA
21h 14m
2 stops
$293Multiple Airlines
Mon, Aug 24 - Thu, Aug 27
American Airlines Logo
6:15 am - 9:39 am
ROA
-
CHS
3h 24m
1 stop
American Airlines Logo
9:13 am - 12:35 pm
CHS
-
ROA
3h 22m
1 stop
$310American Airlines
Fri, Sep 4 - Sat, Sep 5
United Airlines Logo
6:15 am - 9:44 am
ROA
-
MYR
3h 29m
1 stop
United Airlines Logo
10:23 am - 2:18 pm
MYR
-
ROA
3h 55m
1 stop
$348United Airlines
Sat, Aug 22 - Mon, Aug 24
American Airlines Logo
10:35 am - 12:03 pm
ROA
-
CLT
1h 28mnonstop
American Airlines Logo
12:42 pm - 1:53 pm
CLT
-
ROA
1h 11mnonstop
$379American Airlines
Sat, Aug 8 - Sat, Aug 15
United Airlines Logo
6:15 am - 9:44 am
ROA
-
CLT
3h 29m
1 stop
United Airlines Logo
6:00 am - 9:48 am
CLT
-
ROA
3h 48m
1 stop
$399United Airlines
Sat, Aug 8 - Sat, Aug 15

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American Airlines flights from Roanoke to South Carolina

Our best American Airlines deals on Roanoke to South Carolina flight tickets
American Airlines
Sep 4
ROA6:15 amRoanoke
3h 24m
1 stop
CHS9:39 amCharleston
Sep 5
CHS9:13 amCharleston
3h 22m
1 stop
ROA12:35 pmRoanoke
$310
American Airlines
Aug 8
ROA10:35 amRoanoke
1h 28m
CLT12:03 pmCharlotte Douglas
Aug 15
CLT12:42 pmCharlotte Douglas
1h 11m
ROA1:53 pmRoanoke
$379
American Airlines
Sep 20
ROA6:13 pmRoanoke
3h 43m
1 stop
CHS9:56 pmCharleston
Oct 3
CHS5:31 pmCharleston
3h 28m
1 stop
ROA8:59 pmRoanoke
$380

United Airlines flights from Roanoke to South Carolina

Our best United Airlines deals on Roanoke to South Carolina flight tickets
United Airlines
Sep 15
ROA10:26 amRoanoke
4h 24m
1 stop
CHS2:50 pmCharleston
Oct 1
CHS6:00 amCharleston
3h 48m
1 stop
ROA9:48 amRoanoke
$345
United Airlines
Aug 22
ROA6:15 amRoanoke
3h 29m
1 stop
MYR9:44 amMyrtle Beach Intl
Aug 24
MYR10:23 amMyrtle Beach Intl
3h 55m
1 stop
ROA2:18 pmRoanoke
$348
United Airlines
Sep 21
ROA6:15 amRoanoke
3h 48m
1 stop
CHS10:03 amCharleston
Oct 1
CHS7:53 pmCharleston
3h 51m
1 stop
ROA11:44 pmRoanoke
$359

momondo Fare Finder

 
Customize your flight search to find flights from Roanoke to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 30, 2026.
Use the filters below to find and compare flights from Roanoke to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Mon 8/24

2:36 pm-8:38 am

1 stop18h 02m

Charleston

Thu 8/27

2:53 pm-2:05 pm

1 stop23h 12m

$224

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Tue 9/15

6:40 pm-11:57 pm

1 stop5h 17m

Charleston

Wed 9/30

6:40 am-10:31 am

1 stop3h 51m

$261

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Fri 9/18

3:30 pm-10:09 pm

1 stop6h 39m

Charleston

Wed 9/30

5:25 am-10:31 am

1 stop5h 06m

$275

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Thu 7/23

7:57 pm-12:26 am

1 stop4h 29m

Charleston

Sun 7/26

7:59 pm-12:25 am

1 stop4h 26m

$289

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Thu 9/17

6:00 am-10:06 am

1 stop4h 06m

Charleston

Tue 9/29

5:33 pm-11:59 pm

1 stop6h 26m

$290

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Mon 8/24

2:36 pm-8:38 am

1 stop18h 02m

Charleston

Thu 8/27

4:51 pm-2:05 pm

2 stops21h 14m

$293

RoanokeCharleston

ROA - CHS

ROACHS

Roanoke

Fri 9/4

6:15 am-9:39 am

1 stop3h 24m

Charleston

Sat 9/5

9:13 am-12:35 pm

1 stop3h 22m

$310

RoanokeMyrtle Beach

ROA - MYR

ROAMYR

Roanoke

Sat 8/22

6:15 am-9:44 am

1 stop3h 29m

Myrtle Beach Intl

Mon 8/24

10:23 am-2:18 pm

1 stop3h 55m

$348
Quickest round-trip

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Sat 8/8

10:35 am-12:03 pm

Nonstop1h 28m

Charlotte Douglas

Sat 8/15

12:42 pm-1:53 pm

Nonstop1h 11m

$379

RoanokeCharlotte

ROA - CLT

ROACLT

Roanoke

Sat 8/8

6:15 am-9:44 am

1 stop3h 29m

Charlotte Douglas

Sat 8/15

6:00 am-9:48 am

1 stop3h 48m

$399

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Roanoke to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Roanoke is in January. Flight prices, which tend to average around $144, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Roanoke during July instead. Flights to South Carolina in July, while not as cheap as those in January, still average around $201.

Can stopping save me money on Roanoke to South Carolina flights?

You could potentially save up to 1% on your flight if you consider stops on a Roanoke to South Carolina flight.

Cheap Roanoke to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Roanoke to South Carolina

Fastest flight time

3h 29m

Direct flights

Every day

Airports in South Carolina

57 airports
The fastest flight from Roanoke to South Carolina takes 3h 29m
Direct flights go from Roanoke to South Carolina every day.
There are 57 airports in South Carolina. From Roanoke there are direct flights to Charlotte Douglas (CLT).

Frequently asked questions about flying from Roanoke to South Carolina

  • When did momondo last update prices for flights from Roanoke Airport to South Carolina?

    Prices for flights from Roanoke Airport to South Carolina are refreshed on a daily basis.

  • How many operators does momondo search for flights from Roanoke Airport to South Carolina?

  • How old do you have to be to fly from Roanoke Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Roanoke Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Roanoke to South Carolina

Compare and see reviews for airlines that fly from Roanoke to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $201Free CancellationRating
7.8
8,451 reviews
Search Delta flights
American AirlinesPriceFrom $218Free CancellationRating
7.1
11,762 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Roanoke to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Roanoke to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Roanoke to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Roanoke to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Roanoke to South Carolina?

Once all potential Roanoke to South Carolina flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Roanoke to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Roanoke to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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1 adult
Thu 7/30
Thu 8/6

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