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Cheap flights from Portland to Knoxville from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland to Knoxville departing on 9/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Portland to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 4:42 pm
PDX
-
TYS
7h 42m
1 stop
American Airlines Logo
5:35 pm - 11:23 pm
TYS
-
PDX
8h 48m
1 stop
$301American Airlines
Sat, Sep 12 - Tue, Sep 22
American Airlines Logo
11:58 am - 11:18 pm
PDX
-
TYS
8h 20m
1 stop
American Airlines Logo
6:03 am - 10:54 am
TYS
-
PDX
7h 51m
1 stop
$362American Airlines
Sat, Aug 22 - Sat, Aug 29
Delta Logo
10:55 pm - 10:14 am
PDX
-
TYS
8h 19m
1 stop
Delta Logo
7:00 am - 1:25 pm
TYS
-
PDX
9h 25m
1 stop
$395Delta
Tue, Nov 10 - Tue, Nov 17
Multiple Airlines Logo
5:21 pm - 10:23 pm
PDX
-
TYS
26h 02m
2 stops
Multiple Airlines Logo
7:00 am - 4:51 pm
TYS
-
PDX
12h 51m
1 stop
$399Multiple Airlines
Wed, Jul 8 - Sun, Jul 12
American Airlines Logo
11:59 pm - 12:59 pm
PDX
-
TYS
10h 00m
2 stops
American Airlines Logo
4:27 pm - 10:59 pm
TYS
-
PDX
9h 32m
1 stop
$400American Airlines
Tue, Nov 10 - Tue, Nov 17
American Airlines Logo
11:58 am - 11:18 pm
PDX
-
TYS
8h 20m
1 stop
American Airlines Logo
6:03 am - 1:52 pm
TYS
-
PDX
10h 49m
2 stops
$402American Airlines
Sat, Aug 22 - Sat, Aug 29
American Airlines Logo
11:59 pm - 12:59 pm
PDX
-
TYS
10h 00m
2 stops
American Airlines Logo
12:08 pm - 7:49 pm
TYS
-
PDX
10h 41m
2 stops
$405American Airlines
Tue, Nov 10 - Tue, Nov 17
American Airlines Logo
10:30 pm - 10:43 am
PDX
-
TYS
9h 13m
1 stop
American Airlines Logo
6:03 am - 1:52 pm
TYS
-
PDX
10h 49m
2 stops
$410American Airlines
Tue, Aug 4 - Tue, Aug 11
Frontier Logo
12:26 pm - 7:37 pm
PDX
-
TYS
28h 11m
1 stop
Frontier Logo
8:19 pm - 4:51 pm
TYS
-
PDX
23h 32m
1 stop
$414Frontier
Thu, Jul 2 - Wed, Jul 8
American Airlines Logo
11:34 pm - 11:10 am
PDX
-
TYS
8h 36m
1 stop
American Airlines Logo
6:03 am - 10:54 am
TYS
-
PDX
7h 51m
1 stop
$415American Airlines
Wed, Aug 5 - Wed, Aug 12

American Airlines flights from Portland to Knoxville

Our best American Airlines deals on Portland to Knoxville flight tickets
American Airlines
Sep 12
PDX6:00 amPortland
7h 42m
1 stop
TYS4:42 pmKnoxville McGhee Tyson
Sep 22
TYS5:35 pmKnoxville McGhee Tyson
8h 48m
1 stop
PDX11:23 pmPortland
$301
American Airlines
Aug 22
PDX11:58 amPortland
8h 20m
1 stop
TYS11:18 pmKnoxville McGhee Tyson
Aug 29
TYS6:03 amKnoxville McGhee Tyson
7h 51m
1 stop
PDX10:54 amPortland
$362
American Airlines
Nov 10
PDX11:59 pmPortland
10h 00m
2 stops
TYS12:59 pmKnoxville McGhee Tyson
Nov 17
TYS4:27 pmKnoxville McGhee Tyson
9h 32m
1 stop
PDX10:59 pmPortland
$400

Delta flights from Portland to Knoxville

Our best Delta deals on Portland to Knoxville flight tickets
Delta
Nov 10
PDX10:55 pmPortland
8h 19m
1 stop
TYS10:14 amKnoxville McGhee Tyson
Nov 17
TYS7:00 amKnoxville McGhee Tyson
9h 25m
1 stop
PDX1:25 pmPortland
$395
Delta
Sep 20
PDX11:00 pmPortland
8h 17m
1 stop
TYS10:17 amKnoxville McGhee Tyson
Sep 25
TYS6:20 pmKnoxville McGhee Tyson
7h 47m
1 stop
PDX11:07 pmPortland
$467
Delta
Nov 21
PDX1:25 pmPortland
6h 37m
1 stop
TYS11:02 pmKnoxville McGhee Tyson
Dec 1
TYS6:15 pmKnoxville McGhee Tyson
8h 32m
1 stop
PDX11:47 pmPortland
$478

momondo Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 6, 2026.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 9/12

6:00 am-4:42 pm

1 stop7h 42m

Knoxville McGhee Tyson

Tue 9/22

5:35 pm-11:23 pm

1 stop8h 48m

$301
Quickest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 8/22

11:58 am-11:18 pm

1 stop8h 20m

Knoxville McGhee Tyson

Sat 8/29

6:03 am-10:54 am

1 stop7h 51m

$362

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 11/10

10:55 pm-10:14 am

1 stop8h 19m

Knoxville McGhee Tyson

Tue 11/17

7:00 am-1:25 pm

1 stop9h 25m

$395

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 7/8

5:21 pm-10:23 pm

2 stops26h 02m

Knoxville McGhee Tyson

Sun 7/12

7:00 am-4:51 pm

1 stop12h 51m

$399

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 11/10

11:59 pm-12:59 pm

2 stops10h 00m

Knoxville McGhee Tyson

Tue 11/17

4:27 pm-10:59 pm

1 stop9h 32m

$400

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 8/22

11:58 am-11:18 pm

1 stop8h 20m

Knoxville McGhee Tyson

Sat 8/29

6:03 am-1:52 pm

2 stops10h 49m

$402

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 11/10

11:59 pm-12:59 pm

2 stops10h 00m

Knoxville McGhee Tyson

Tue 11/17

12:08 pm-7:49 pm

2 stops10h 41m

$405

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 8/4

10:30 pm-10:43 am

1 stop9h 13m

Knoxville McGhee Tyson

Tue 8/11

6:03 am-1:52 pm

2 stops10h 49m

$410

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Thu 7/2

12:26 pm-7:37 pm

1 stop28h 11m

Knoxville McGhee Tyson

Wed 7/8

8:19 pm-4:51 pm

1 stop23h 32m

$414

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 8/5

11:34 pm-11:10 am

1 stop8h 36m

Knoxville McGhee Tyson

Wed 8/12

6:03 am-10:54 am

1 stop7h 51m

$415

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Portland, with most prices found around $388. If you aren’t able to travel during the month of August, then book flights to Knoxville from Portland during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $398.

How far in advance should I book a flight from Portland to Knoxville?

You are more likely to see cheaper flights to Knoxville from Portland when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $462 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Portland for as low as $366 on momondo.

How have Portland to Knoxville flight prices changed over time?

As of June 2026, prices for Portland to Knoxville flights are approximately 24% cheaper when compared to flights at the same time last year.

When to book flights from Portland to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland to Knoxville (PDX to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland to Knoxville

Fastest flight time

7h 03m

Direct flights

None
The fastest flight from Portland to Knoxville takes 7h 03m
There are no direct flights from Portland to Knoxville. There are no popular flight routes from Portland to Knoxville.
Search flight deals

Frequently asked questions about flying from Portland to Knoxville

  • How far is Portland to Knoxville McGhee Tyson by plane?

    Portland and Knoxville McGhee Tyson are 2108.9 mi apart from one another. A reasonable flight in good conditions will take 7h 03m.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland to Knoxville?

Best airlines flying from Portland to Knoxville

Compare and see reviews for airlines that fly from Portland to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $139Free CancellationRating
5.6
2,908 reviews
Search Frontier flights
DeltaPriceFrom $268Free CancellationRating
7.8
8,395 reviews
Search Delta flights
American AirlinesPriceFrom $308Free CancellationRating
7.1
11,650 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,777 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Maryville
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Flights from Portland to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Portland to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Portland. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Portland and alert you when they change.

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