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Cheap flights from Portland to Knoxville from $123

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland to Knoxville departing on 10/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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American Airlines Logo
2:07 pm - 12:08 amPDX-TYS
7h 01m1 stop
American Airlines Logo
5:10 am - 11:09 amTYS-PDX
8h 59m1 stop
$269American Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
Delta Logo
11:20 pm - 11:47 amPDX-TYS
9h 27m1 stop
Delta Logo
8:45 am - 8:52 pmTYS-PDX
15h 07m2 stops
$274Delta
Find Deal
Tue, Dec 9 - Sat, Dec 13
Delta Logo
10:10 pm - 11:47 amPDX-TYS
10h 37m2 stops
Delta Logo
8:45 am - 5:43 pmTYS-PDX
11h 58m2 stops
$279Delta
Find Deal
Tue, Dec 9 - Sat, Dec 13
American Airlines Logo
10:15 pm - 9:54 amPDX-TYS
8h 39m1 stop
American Airlines Logo
6:18 pm - 11:23 pmTYS-PDX
8h 05m1 stop
$294American Airlines
Find Deal
Tue, Dec 9 - Sat, Dec 13
American Airlines Logo
7:38 am - 5:27 pmPDX-TYS
6h 49m1 stop
American Airlines Logo
5:03 pm - 11:52 pmTYS-PDX
9h 49m1 stop
$299American Airlines
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Fri, Dec 5 - Tue, Dec 9
Delta Logo
10:05 am - 11:50 pmPDX-TYS
10h 45m2 stops
Delta Logo
5:25 am - 10:44 amTYS-PDX
8h 19m1 stop
$304Delta
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Fri, Dec 5 - Tue, Dec 9
United Airlines Logo
12:59 pm - 11:44 pmPDX-TYS
7h 45m1 stop
United Airlines Logo
4:25 pm - 9:12 pmTYS-PDX
7h 47m1 stop
$353United Airlines
Find Deal
Mon, Jan 26 - Wed, Jan 28
United Airlines Logo
7:00 am - 6:05 pmPDX-TYS
8h 05m1 stop
United Airlines Logo
11:10 am - 6:10 pmTYS-PDX
10h 00m2 stops
$358United Airlines
Find Deal
Mon, Jan 26 - Wed, Jan 28
Alaska Airlines Logo
8:45 pm - 9:03 pmPDX-TYS
21h 18m2 stops
Alaska Airlines Logo
3:40 pm - 12:09 amTYS-PDX
11h 29m2 stops
$529Alaska Airlines
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Thu, Nov 13 - Mon, Nov 17
Alaska Airlines Logo
4:34 pm - 9:42 pmPDX-TYS
26h 08m2 stops
Alaska Airlines Logo
11:10 am - 12:03 amTYS-PDX
15h 53m2 stops
$547Alaska Airlines
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Mon, Feb 9 - Thu, Feb 12

American Airlines flights from Portland to Knoxville

Our best American Airlines deals on Portland to Knoxville flight tickets
American Airlines
Nov 4
PDX2:07 pmPortland
7h 01m
1 stop
TYS12:08 amKnoxville McGhee Tyson
Nov 8
TYS5:10 amKnoxville McGhee Tyson
8h 59m
1 stop
PDX11:09 amPortland
$269
Find similar
American Airlines
Dec 9
PDX10:15 pmPortland
8h 39m
1 stop
TYS9:54 amKnoxville McGhee Tyson
Dec 13
TYS6:18 pmKnoxville McGhee Tyson
8h 05m
1 stop
PDX11:23 pmPortland
$294
Find similar
American Airlines
Dec 5
PDX7:38 amPortland
6h 49m
1 stop
TYS5:27 pmKnoxville McGhee Tyson
Dec 9
TYS5:03 pmKnoxville McGhee Tyson
9h 49m
1 stop
PDX11:52 pmPortland
$299
Find similar

Delta flights from Portland to Knoxville

Our best Delta deals on Portland to Knoxville flight tickets
Delta
Dec 9
PDX11:20 pmPortland
9h 27m
1 stop
TYS11:47 amKnoxville McGhee Tyson
Dec 13
TYS8:45 amKnoxville McGhee Tyson
15h 07m
2 stops
PDX8:52 pmPortland
$274
Find similar
Delta
Dec 9
PDX10:10 pmPortland
10h 37m
2 stops
TYS11:47 amKnoxville McGhee Tyson
Dec 13
TYS8:45 amKnoxville McGhee Tyson
11h 58m
2 stops
PDX5:43 pmPortland
$279
Find similar
Delta
Dec 5
PDX10:05 amPortland
10h 45m
2 stops
TYS11:50 pmKnoxville McGhee Tyson
Dec 9
TYS5:25 amKnoxville McGhee Tyson
8h 19m
1 stop
PDX10:44 amPortland
$304
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 11/4

2:07 pm-12:08 am

1 stop7h 01m

Knoxville McGhee Tyson

Sat 11/8

5:10 am-11:09 am

1 stop8h 59m

$269

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 12/9

11:20 pm-11:47 am

1 stop9h 27m

Knoxville McGhee Tyson

Sat 12/13

8:45 am-8:52 pm

2 stops15h 07m

$274

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 12/9

10:10 pm-11:47 am

2 stops10h 37m

Knoxville McGhee Tyson

Sat 12/13

8:45 am-5:43 pm

2 stops11h 58m

$279

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 12/9

10:15 pm-9:54 am

1 stop8h 39m

Knoxville McGhee Tyson

Sat 12/13

6:18 pm-11:23 pm

1 stop8h 05m

$294

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Fri 12/5

7:38 am-5:27 pm

1 stop6h 49m

Knoxville McGhee Tyson

Tue 12/9

5:03 pm-11:52 pm

1 stop9h 49m

$299

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Fri 12/5

10:05 am-11:50 pm

2 stops10h 45m

Knoxville McGhee Tyson

Tue 12/9

5:25 am-10:44 am

1 stop8h 19m

$304

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Mon 1/26

12:59 pm-11:44 pm

1 stop7h 45m

Knoxville McGhee Tyson

Wed 1/28

4:25 pm-9:12 pm

1 stop7h 47m

$353

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Mon 1/26

7:00 am-6:05 pm

1 stop8h 05m

Knoxville McGhee Tyson

Wed 1/28

11:10 am-6:10 pm

2 stops10h 00m

$358

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Thu 11/13

8:45 pm-9:03 pm

2 stops21h 18m

Knoxville McGhee Tyson

Mon 11/17

3:40 pm-12:09 am

2 stops11h 29m

$529

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Mon 2/9

4:34 pm-9:42 pm

2 stops26h 08m

Knoxville McGhee Tyson

Thu 2/12

11:10 am-12:03 am

2 stops15h 53m

$547

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Portland, with most prices found around $383. If you aren’t able to travel during the month of August, then book flights to Knoxville from Portland during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $388.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Portland to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $442. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Portland to Knoxville for around $583.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Portland to Knoxville when you can find flight prices for as low as $460. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $478.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Portland when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $460 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Portland for as low as $329 on momondo.

How have Portland to Knoxville flight prices changed over time?

As of October 2025, prices for Portland to Knoxville flights are approximately 44% cheaper when compared to flights at the same time last year.

When to book flights from Portland to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland to Knoxville (PDX to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland to Knoxville

Direct flights

None
There are no direct flights from Portland to Knoxville. There are no popular flight routes from Portland to Knoxville.
Search flight deals

  • How far is Portland to Knoxville McGhee Tyson by plane?

    Portland and Knoxville McGhee Tyson are 2108.9 mi apart from one another. A reasonable flight in good conditions will take 6h 34m.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland to Knoxville?

Best airlines flying from Portland to Knoxville

Compare and see reviews for airlines that fly from Portland to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $195Free CancellationRating
5.8
3,137 reviews
Search Frontier flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,982 reviews
Search United Airlines flights
American AirlinesPriceFrom $293Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
DeltaPriceFrom $298Free CancellationRating
7.9
7,984 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Flights from Portland to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Portland to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Portland. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Portland and alert you when they change.

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