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Cheap flights from Portland to Knoxville from $141

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland to Knoxville departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Portland to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:27 pm - 3:33 pm
PDX
-
TYS
24h 06m
1 stop
Multiple Airlines Logo
1:43 pm - 11:52 am
TYS
-
PDX
25h 09m
2 stops
$241Multiple Airlines
Sat, Apr 18 - Mon, Apr 20
Frontier Logo
3:12 pm - 7:13 pm
PDX
-
TYS
25h 01m
1 stop
Frontier Logo
8:08 pm - 11:13 am
TYS
-
PDX
18h 05m
1 stop
$358Frontier
Thu, Aug 20 - Mon, Aug 24
United Airlines Logo
11:59 pm - 10:08 am
PDX
-
TYS
7h 09m
1 stop
United Airlines Logo
7:00 am - 11:46 am
TYS
-
PDX
7h 46m
1 stop
$359United Airlines
Tue, Apr 7 - Tue, Apr 21
United Airlines Logo
11:59 pm - 10:08 am
PDX
-
TYS
7h 09m
1 stop
United Airlines Logo
10:49 am - 6:07 pm
TYS
-
PDX
10h 18m
2 stops
$364United Airlines
Tue, Apr 7 - Tue, Apr 28
United Airlines Logo
10:50 am - 10:43 pm
PDX
-
TYS
8h 53m
1 stop
United Airlines Logo
5:53 pm - 10:34 pm
TYS
-
PDX
7h 41m
1 stop
$367United Airlines
Tue, Apr 14 - Tue, Apr 21
Delta Logo
12:30 am - 4:42 pm
PDX
-
TYS
13h 12m
2 stops
Delta Logo
3:05 pm - 11:44 pm
TYS
-
PDX
11h 39m
2 stops
$370Delta
Mon, Apr 20 - Tue, May 12
American Airlines Logo
11:40 pm - 10:26 am
PDX
-
TYS
7h 46m
1 stop
American Airlines Logo
2:06 pm - 9:38 pm
TYS
-
PDX
10h 32m
2 stops
$372American Airlines
Tue, Apr 28 - Sat, May 2
American Airlines Logo
11:40 pm - 12:30 pm
PDX
-
TYS
9h 50m
1 stop
American Airlines Logo
6:54 pm - 11:54 pm
TYS
-
PDX
8h 00m
1 stop
$376American Airlines
Wed, Apr 8 - Mon, Apr 13
American Airlines Logo
6:00 am - 6:04 pm
PDX
-
TYS
9h 04m
1 stop
American Airlines Logo
2:06 pm - 9:38 pm
TYS
-
PDX
10h 32m
2 stops
$377American Airlines
Tue, Apr 28 - Sat, May 2
Delta Logo
7:32 pm - 10:21 am
PDX
-
TYS
11h 49m
2 stops
Delta Logo
5:26 pm - 11:56 pm
TYS
-
PDX
9h 30m
2 stops
$378Delta
Tue, Apr 14 - Tue, Apr 21

American Airlines flights from Portland to Knoxville

Our best American Airlines deals on Portland to Knoxville flight tickets
American Airlines
Apr 28
PDX11:40 pmPortland
7h 46m
1 stop
TYS10:26 amKnoxville McGhee Tyson
May 2
TYS2:06 pmKnoxville McGhee Tyson
10h 32m
2 stops
PDX9:38 pmPortland
$372
American Airlines
Apr 8
PDX11:40 pmPortland
9h 50m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
Apr 13
TYS6:54 pmKnoxville McGhee Tyson
8h 00m
1 stop
PDX11:54 pmPortland
$376
American Airlines
Apr 28
PDX6:00 amPortland
9h 04m
1 stop
TYS6:04 pmKnoxville McGhee Tyson
May 2
TYS2:06 pmKnoxville McGhee Tyson
10h 32m
2 stops
PDX9:38 pmPortland
$377

Delta flights from Portland to Knoxville

Our best Delta deals on Portland to Knoxville flight tickets
Delta
Apr 20
PDX12:30 amPortland
13h 12m
2 stops
TYS4:42 pmKnoxville McGhee Tyson
May 12
TYS3:05 pmKnoxville McGhee Tyson
11h 39m
2 stops
PDX11:44 pmPortland
$370
Delta
Apr 14
PDX7:32 pmPortland
11h 49m
2 stops
TYS10:21 amKnoxville McGhee Tyson
Apr 21
TYS5:26 pmKnoxville McGhee Tyson
9h 30m
2 stops
PDX11:56 pmPortland
$378
Delta
Apr 13
PDX10:55 pmPortland
9h 22m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Apr 21
TYS5:26 pmKnoxville McGhee Tyson
9h 30m
2 stops
PDX11:56 pmPortland
$381

momondo Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 4/18

12:27 pm-3:33 pm

1 stop24h 06m

Knoxville McGhee Tyson

Mon 4/20

1:43 pm-11:52 am

2 stops25h 09m

$241

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Thu 8/20

3:12 pm-7:13 pm

1 stop25h 01m

Knoxville McGhee Tyson

Mon 8/24

8:08 pm-11:13 am

1 stop18h 05m

$358
Quickest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 4/7

11:59 pm-10:08 am

1 stop7h 09m

Knoxville McGhee Tyson

Tue 4/21

7:00 am-11:46 am

1 stop7h 46m

$359

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 4/7

11:59 pm-10:08 am

1 stop7h 09m

Knoxville McGhee Tyson

Tue 4/28

10:49 am-6:07 pm

2 stops10h 18m

$364

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 4/14

10:50 am-10:43 pm

1 stop8h 53m

Knoxville McGhee Tyson

Tue 4/21

5:53 pm-10:34 pm

1 stop7h 41m

$367

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Mon 4/20

12:30 am-4:42 pm

2 stops13h 12m

Knoxville McGhee Tyson

Tue 5/12

3:05 pm-11:44 pm

2 stops11h 39m

$370

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 4/28

11:40 pm-10:26 am

1 stop7h 46m

Knoxville McGhee Tyson

Sat 5/2

2:06 pm-9:38 pm

2 stops10h 32m

$372

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 4/8

11:40 pm-12:30 pm

1 stop9h 50m

Knoxville McGhee Tyson

Mon 4/13

6:54 pm-11:54 pm

1 stop8h 00m

$376

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 4/28

6:00 am-6:04 pm

1 stop9h 04m

Knoxville McGhee Tyson

Sat 5/2

2:06 pm-9:38 pm

2 stops10h 32m

$377

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 4/14

7:32 pm-10:21 am

2 stops11h 49m

Knoxville McGhee Tyson

Tue 4/21

5:26 pm-11:56 pm

2 stops9h 30m

$378

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Portland, with most prices found around $383. If you aren’t able to travel during the month of August, then book flights to Knoxville from Portland during September instead. Flights to Knoxville in September, while not as cheap as those in August, still average around $403.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Portland when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $452 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Portland for as low as $371 on momondo.

How have Portland to Knoxville flight prices changed over time?

As of March 2026, prices for Portland to Knoxville flights are approximately 10% cheaper when compared to flights at the same time last year.

When to book flights from Portland to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland to Knoxville (PDX to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland to Knoxville

Fastest flight time

7h 09m

Direct flights

None
The fastest flight from Portland to Knoxville takes 7h 09m
There are no direct flights from Portland to Knoxville. There are no popular flight routes from Portland to Knoxville.
Search flight deals

  • How far is Portland to Knoxville McGhee Tyson by plane?

    Portland and Knoxville McGhee Tyson are 2108.9 mi apart from one another. A reasonable flight in good conditions will take 7h 09m.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland to Knoxville?

Best airlines flying from Portland to Knoxville

Compare and see reviews for airlines that fly from Portland to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $240Free CancellationRating
5.7
3,041 reviews
Search Frontier flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,403 reviews
Search United Airlines flights
DeltaPriceFrom $268Free CancellationRating
7.9
8,258 reviews
Search Delta flights
American AirlinesPriceFrom $284Free CancellationRating
7.1
11,393 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Kodak
Newport
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Flights from Portland to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Portland to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Portland. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Portland and alert you when they change.

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