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Cheap flights from Portland to Knoxville from $124

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland to Knoxville departing on 8/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Portland to Knoxville

Cheap round-trip flights

Frontier Logo
6:05 am - 7:45 pmPDX-TYS
10h 40m1 stop
Frontier Logo
8:40 pm - 12:12 amTYS-PDX
6h 32m1 stop
$154Frontier
Find Deal
Mon, Sep 8 - Thu, Sep 11
United Airlines Logo
5:00 am - 3:10 pmPDX-TYS
7h 10m1 stop
United Airlines Logo
4:40 pm - 9:01 pmTYS-PDX
7h 21m1 stop
$251United Airlines
Find Deal
Tue, Sep 16 - Tue, Sep 23
American Airlines Logo
6:07 am - 4:19 pmPDX-TYS
7h 12m1 stop
American Airlines Logo
6:00 am - 1:16 pmTYS-PDX
10h 16m2 stops
$256American Airlines
Find Deal
Tue, Sep 16 - Tue, Sep 23
Frontier Logo
6:27 am - 7:41 pmPDX-TYS
10h 14m1 stop
Frontier Logo
5:08 pm - 12:12 amTYS-PDX
10h 04m1 stop
$278Frontier
Find Deal
Sun, Aug 31 - Sun, Sep 7
Frontier Logo
6:05 am - 7:50 pmPDX-TYS
10h 45m1 stop
Frontier Logo
8:40 pm - 12:12 amTYS-PDX
6h 32m1 stop
$279Frontier
Find Deal
Thu, Sep 4 - Thu, Sep 11
American Airlines Logo
9:56 pm - 9:56 amPDX-TYS
9h 00m1 stop
American Airlines Logo
4:37 pm - 9:27 pmTYS-PDX
7h 50m1 stop
$280American Airlines
Find Deal
Fri, Sep 12 - Tue, Sep 23
Logo
6:05 am - 10:21 pmPDX-TYS
13h 16m2 stops
Logo
7:00 am - 12:12 amTYS-PDX
20h 12m1 stop
$288
Find Deal
Fri, Sep 26 - Sun, Sep 28
Delta Logo
11:30 am - 11:44 pmPDX-TYS
9h 14m2 stops
Delta Logo
6:40 am - 10:39 amTYS-PDX
6h 59m1 stop
$310Delta
Find Deal
Tue, Sep 16 - Tue, Sep 23
Delta Logo
10:05 pm - 11:34 amPDX-TYS
10h 29m2 stops
Delta Logo
6:40 am - 12:35 pmTYS-PDX
8h 55m1 stop
$315Delta
Find Deal
Sun, Sep 7 - Sat, Sep 13
Logo
8:36 pm - 9:17 pmPDX-TYS
21h 41m2 stops
Logo
12:45 pm - 8:23 amTYS-PDX
22h 38m1 stop
$316
Find Deal
Wed, Oct 8 - Sat, Oct 18

Frontier flights from Portland to Knoxville

Our best Frontier deals on Portland to Knoxville flight tickets
Frontier
Sep 8
PDX6:05 amPortland
10h 40m
1 stop
TYS7:45 pmKnoxville McGhee Tyson
Sep 11
TYS8:40 pmKnoxville McGhee Tyson
6h 32m
1 stop
PDX12:12 amPortland
$154
Find similar
Frontier
Aug 31
PDX6:27 amPortland
10h 14m
1 stop
TYS7:41 pmKnoxville McGhee Tyson
Sep 7
TYS5:08 pmKnoxville McGhee Tyson
10h 04m
1 stop
PDX12:12 amPortland
$278
Find similar
Frontier
Sep 4
PDX6:05 amPortland
10h 45m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
Sep 11
TYS8:40 pmKnoxville McGhee Tyson
6h 32m
1 stop
PDX12:12 amPortland
$279
Find similar

Delta flights from Portland to Knoxville

Our best Delta deals on Portland to Knoxville flight tickets
Delta
Sep 16
PDX11:30 amPortland
9h 14m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Sep 23
TYS6:40 amKnoxville McGhee Tyson
6h 59m
1 stop
PDX10:39 amPortland
$310
Find similar
Delta
Sep 7
PDX10:05 pmPortland
10h 29m
2 stops
TYS11:34 amKnoxville McGhee Tyson
Sep 13
TYS6:40 amKnoxville McGhee Tyson
8h 55m
1 stop
PDX12:35 pmPortland
$315
Find similar
Delta
Sep 20
PDX5:50 pmPortland
12h 54m
2 stops
TYS9:44 amKnoxville McGhee Tyson
Sep 24
TYS5:45 amKnoxville McGhee Tyson
10h 15m
2 stops
PDX1:00 pmPortland
$319
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Mon 9/8

6:05 am-7:45 pm

1 stop10h 40m

Knoxville McGhee Tyson

Thu 9/11

8:40 pm-12:12 am

1 stop6h 32m

$154

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 9/16

5:00 am-3:10 pm

1 stop7h 10m

Knoxville McGhee Tyson

Tue 9/23

4:40 pm-9:01 pm

1 stop7h 21m

$251

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 9/16

6:07 am-4:19 pm

1 stop7h 12m

Knoxville McGhee Tyson

Tue 9/23

6:00 am-1:16 pm

2 stops10h 16m

$256

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sun 8/31

6:27 am-7:41 pm

1 stop10h 14m

Knoxville McGhee Tyson

Sun 9/7

5:08 pm-12:12 am

1 stop10h 04m

$278

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Thu 9/4

6:05 am-7:50 pm

1 stop10h 45m

Knoxville McGhee Tyson

Thu 9/11

8:40 pm-12:12 am

1 stop6h 32m

$279

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Fri 9/12

9:56 pm-9:56 am

1 stop9h 00m

Knoxville McGhee Tyson

Tue 9/23

4:37 pm-9:27 pm

1 stop7h 50m

$280

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Fri 9/26

6:05 am-10:21 pm

2 stops13h 16m

Knoxville McGhee Tyson

Sun 9/28

7:00 am-12:12 am

1 stop20h 12m

$288

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 9/16

11:30 am-11:44 pm

2 stops9h 14m

Knoxville McGhee Tyson

Tue 9/23

6:40 am-10:39 am

1 stop6h 59m

$310

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sun 9/7

10:05 pm-11:34 am

2 stops10h 29m

Knoxville McGhee Tyson

Sat 9/13

6:40 am-12:35 pm

1 stop8h 55m

$315

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 10/8

8:36 pm-9:17 pm

2 stops21h 41m

Knoxville McGhee Tyson

Sat 10/18

12:45 pm-8:23 am

1 stop22h 38m

$316

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of February is, on average, the cheapest month to fly to Knoxville from Portland, with most prices found around $380. If you aren’t able to travel during the month of February, then book flights to Knoxville from Portland during January instead. Flights to Knoxville in January, while not as cheap as those in February, still average around $413.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Portland to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $442. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Portland to Knoxville for around $583.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Portland to Knoxville when you can find flight prices for as low as $460. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $478.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Portland when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $468 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Portland for as low as $336 on momondo.

How have Portland to Knoxville flight prices changed over time?

As of August 2025, prices for Portland to Knoxville flights are approximately 6% more expensive when compared to flights at the same time last year.

When to book flights from Portland to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland to Knoxville (PDX to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland to Knoxville

Direct flights

None
There are no direct flights from Portland to Knoxville. There are no popular flight routes from Portland to Knoxville.
Search flight deals

  • How far is Portland to Knoxville McGhee Tyson by plane?

    Portland and Knoxville McGhee Tyson are 2108.9 mi apart from one another. A reasonable flight in good conditions will take 6h 00m.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland to Knoxville?

Best airlines flying from Portland to Knoxville

Compare and see reviews for airlines that fly from Portland to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
FrontierPriceFrom $157Free CancellationRating
5.8
3,207 reviews
Search Frontier flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
American AirlinesPriceFrom $292Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $308Free CancellationRating
7.9
7,981 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Flights from Portland to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Portland to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Portland. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Portland and alert you when they change.

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