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Cheap flights from Portland to Knoxville from $211

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland to Knoxville departing on 6/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Portland to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:35 pm - 1:59 pm
PDX
-
TYS
22h 24m
1 stop
Multiple Airlines Logo
7:00 am - 4:46 pm
TYS
-
PDX
12h 46m
1 stop
$282Multiple Airlines
Sat, May 23 - Thu, May 28
Delta Logo
11:12 pm - 10:21 am
PDX
-
TYS
8h 09m
1 stop
Delta Logo
3:30 pm - 9:46 pm
TYS
-
PDX
9h 16m
1 stop
$293Delta
Tue, May 26 - Wed, May 27
Multiple Airlines Logo
12:35 pm - 7:24 pm
PDX
-
TYS
27h 49m
1 stop
Multiple Airlines Logo
7:00 am - 4:46 pm
TYS
-
PDX
12h 46m
1 stop
$297Multiple Airlines
Sun, May 24 - Thu, May 28
Multiple Airlines Logo
5:31 pm - 1:59 pm
PDX
-
TYS
17h 28m
2 stops
Multiple Airlines Logo
7:00 am - 4:46 pm
TYS
-
PDX
12h 46m
1 stop
$310Multiple Airlines
Sat, May 23 - Thu, May 28
Multiple Airlines Logo
12:35 pm - 1:59 pm
PDX
-
TYS
22h 24m
1 stop
Multiple Airlines Logo
8:19 pm - 11:50 am
TYS
-
PDX
18h 31m
2 stops
$314Multiple Airlines
Sat, May 23 - Fri, May 29
Multiple Airlines Logo
5:31 pm - 7:24 pm
PDX
-
TYS
22h 53m
2 stops
Multiple Airlines Logo
7:00 am - 4:46 pm
TYS
-
PDX
12h 46m
1 stop
$315Multiple Airlines
Sun, May 24 - Thu, May 28
Delta Logo
2:06 pm - 11:56 pm
PDX
-
TYS
6h 50m
1 stop
Delta Logo
6:36 am - 10:53 am
TYS
-
PDX
7h 17m
1 stop
$324Delta
Tue, May 26 - Thu, May 28
Frontier Logo
12:35 pm - 7:24 pm
PDX
-
TYS
27h 49m
1 stop
Frontier Logo
8:19 pm - 11:50 am
TYS
-
PDX
18h 31m
2 stops
$329Frontier
Sun, May 24 - Fri, May 29
Multiple Airlines Logo
12:35 pm - 1:59 pm
PDX
-
TYS
22h 24m
1 stop
Multiple Airlines Logo
2:20 pm - 1:54 pm
TYS
-
PDX
26h 34m
2 stops
$335Multiple Airlines
Sat, May 23 - Wed, May 27
Multiple Airlines Logo
12:35 pm - 1:59 pm
PDX
-
TYS
22h 24m
1 stop
Multiple Airlines Logo
8:19 pm - 4:46 pm
TYS
-
PDX
23h 27m
1 stop
$340Multiple Airlines
Sat, May 23 - Fri, May 29

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United Airlines flights from Portland to Knoxville

Our best United Airlines deals on Portland to Knoxville flight tickets
United Airlines
Sep 19
PDX5:00 amPortland
8h 59m
2 stops
TYS4:59 pmKnoxville McGhee Tyson
Sep 26
TYS7:00 amKnoxville McGhee Tyson
7h 35m
1 stop
PDX11:35 amPortland
$422
United Airlines
Aug 11
PDX7:00 amPortland
6h 59m
1 stop
TYS4:59 pmKnoxville McGhee Tyson
Aug 12
TYS4:56 pmKnoxville McGhee Tyson
8h 56m
1 stop
PDX10:52 pmPortland
$434
United Airlines
Aug 11
PDX7:13 pmPortland
11h 55m
2 stops
TYS10:08 amKnoxville McGhee Tyson
Aug 12
TYS5:57 pmKnoxville McGhee Tyson
8h 12m
1 stop
PDX11:09 pmPortland
$439

American Airlines flights from Portland to Knoxville

Our best American Airlines deals on Portland to Knoxville flight tickets
American Airlines
May 23
PDX11:59 amPortland
8h 57m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
May 27
TYS6:20 pmKnoxville McGhee Tyson
8h 32m
1 stop
PDX11:52 pmPortland
$344
American Airlines
May 31
PDX12:40 amPortland
7h 33m
1 stop
TYS11:13 amKnoxville McGhee Tyson
Jun 4
TYS8:11 pmKnoxville McGhee Tyson
7h 39m
1 stop
PDX12:50 amPortland
$355
American Airlines
Jun 8
PDX12:40 amPortland
9h 23m
1 stop
TYS1:03 pmKnoxville McGhee Tyson
Jun 23
TYS5:33 pmKnoxville McGhee Tyson
10h 17m
1 stop
PDX12:50 amPortland
$375

momondo Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 22, 2026.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 5/23

12:35 pm-1:59 pm

1 stop22h 24m

Knoxville McGhee Tyson

Thu 5/28

7:00 am-4:46 pm

1 stop12h 46m

$282

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 5/26

11:12 pm-10:21 am

1 stop8h 09m

Knoxville McGhee Tyson

Wed 5/27

3:30 pm-9:46 pm

1 stop9h 16m

$293

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sun 5/24

12:35 pm-7:24 pm

1 stop27h 49m

Knoxville McGhee Tyson

Thu 5/28

7:00 am-4:46 pm

1 stop12h 46m

$297

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 5/23

5:31 pm-1:59 pm

2 stops17h 28m

Knoxville McGhee Tyson

Thu 5/28

7:00 am-4:46 pm

1 stop12h 46m

$310

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 5/23

12:35 pm-1:59 pm

1 stop22h 24m

Knoxville McGhee Tyson

Fri 5/29

8:19 pm-11:50 am

2 stops18h 31m

$314

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sun 5/24

5:31 pm-7:24 pm

2 stops22h 53m

Knoxville McGhee Tyson

Thu 5/28

7:00 am-4:46 pm

1 stop12h 46m

$315
Quickest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Tue 5/26

2:06 pm-11:56 pm

1 stop6h 50m

Knoxville McGhee Tyson

Thu 5/28

6:36 am-10:53 am

1 stop7h 17m

$324

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sun 5/24

12:35 pm-7:24 pm

1 stop27h 49m

Knoxville McGhee Tyson

Fri 5/29

8:19 pm-11:50 am

2 stops18h 31m

$329

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 5/23

12:35 pm-1:59 pm

1 stop22h 24m

Knoxville McGhee Tyson

Wed 5/27

2:20 pm-1:54 pm

2 stops26h 34m

$335

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 5/23

12:35 pm-1:59 pm

1 stop22h 24m

Knoxville McGhee Tyson

Fri 5/29

8:19 pm-4:46 pm

1 stop23h 27m

$340

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Portland, with most prices found around $383. If you aren’t able to travel during the month of August, then book flights to Knoxville from Portland during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $398.

How far in advance should I book a flight from Portland to Knoxville?

You are more likely to see cheaper flights to Knoxville from Portland when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $456 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Portland for as low as $376 on momondo.

How have Portland to Knoxville flight prices changed over time?

As of April 2026, prices for Portland to Knoxville flights are approximately 52% more expensive when compared to flights at the same time last year.

When to book flights from Portland to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland to Knoxville (PDX to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland to Knoxville

Fastest flight time

6h 44m

Direct flights

None
The fastest flight from Portland to Knoxville takes 6h 44m
There are no direct flights from Portland to Knoxville. There are no popular flight routes from Portland to Knoxville.
Search flight deals

Frequently asked questions about flying from Portland to Knoxville

  • How far is Portland to Knoxville McGhee Tyson by plane?

    Portland and Knoxville McGhee Tyson are 2108.9 mi apart from one another. A reasonable flight in good conditions will take 6h 44m.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland to Knoxville?

Best airlines flying from Portland to Knoxville

Compare and see reviews for airlines that fly from Portland to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $256Free CancellationRating
7.9
8,431 reviews
Search Delta flights
FrontierPriceFrom $264Free CancellationRating
5.6
2,982 reviews
Search Frontier flights
United AirlinesPriceFrom $279Free CancellationRating
7.4
9,625 reviews
Search United Airlines flights
American AirlinesPriceFrom $304Free CancellationRating
7.1
11,647 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Flights from Portland to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Portland to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Portland. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Portland and alert you when they change.

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