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Cheap flights from Portland to Knoxville from $178

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland to Knoxville departing on 8/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Portland to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:56 pm - 1:44 pm
PDX
-
TYS
16h 48m
1 stop
Multiple Airlines Logo
7:00 am - 5:11 pm
TYS
-
PDX
13h 11m
1 stop
$290Multiple Airlines
Wed, Sep 2 - Sun, Sep 6
Multiple Airlines Logo
5:35 pm - 1:11 pm
PDX
-
TYS
16h 36m
1 stop
Multiple Airlines Logo
6:30 am - 4:35 pm
TYS
-
PDX
13h 05m
1 stop
$313Multiple Airlines
Wed, Oct 21 - Sun, Oct 25
Multiple Airlines Logo
5:56 pm - 1:49 pm
PDX
-
TYS
16h 53m
1 stop
Multiple Airlines Logo
7:00 am - 5:11 pm
TYS
-
PDX
13h 11m
1 stop
$329Multiple Airlines
Wed, Aug 26 - Sun, Aug 30
Multiple Airlines Logo
3:22 pm - 1:44 pm
PDX
-
TYS
19h 22m
1 stop
Multiple Airlines Logo
7:00 am - 4:35 pm
TYS
-
PDX
12h 35m
1 stop
$341Multiple Airlines
Sat, Sep 19 - Thu, Sep 24
Multiple Airlines Logo
3:22 pm - 1:44 pm
PDX
-
TYS
19h 22m
1 stop
Multiple Airlines Logo
1:31 pm - 4:35 pm
TYS
-
PDX
30h 04m
2 stops
$344Multiple Airlines
Sat, Sep 19 - Fri, Sep 25
Multiple Airlines Logo
3:22 pm - 1:27 pm
PDX
-
TYS
19h 05m
2 stops
Multiple Airlines Logo
7:00 am - 4:35 pm
TYS
-
PDX
12h 35m
1 stop
$345Multiple Airlines
Thu, Sep 17 - Thu, Sep 24
Multiple Airlines Logo
5:56 pm - 12:02 pm
PDX
-
TYS
15h 06m
2 stops
Multiple Airlines Logo
7:00 am - 5:11 pm
TYS
-
PDX
13h 11m
1 stop
$347Multiple Airlines
Wed, Sep 2 - Sun, Sep 6
Multiple Airlines Logo
3:22 pm - 1:44 pm
PDX
-
TYS
19h 22m
1 stop
Multiple Airlines Logo
8:00 am - 2:27 pm
TYS
-
PDX
33h 27m
2 stops
$353Multiple Airlines
Wed, Sep 16 - Mon, Sep 21
American Airlines Logo
6:00 am - 4:42 pm
PDX
-
TYS
7h 42m
1 stop
American Airlines Logo
2:43 pm - 7:20 pm
TYS
-
PDX
7h 37m
1 stop
$355American Airlines
Sat, Sep 12 - Tue, Sep 22
Multiple Airlines Logo
3:22 pm - 1:44 pm
PDX
-
TYS
19h 22m
1 stop
Multiple Airlines Logo
7:00 am - 4:35 pm
TYS
-
PDX
12h 35m
1 stop
$358Multiple Airlines
Wed, Sep 16 - Thu, Sep 24

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American Airlines flights from Portland to Knoxville

Our best American Airlines deals on Portland to Knoxville flight tickets
American Airlines
Sep 12
PDX6:00 amPortland
7h 42m
1 stop
TYS4:42 pmKnoxville McGhee Tyson
Sep 22
TYS2:43 pmKnoxville McGhee Tyson
7h 37m
1 stop
PDX7:20 pmPortland
$355
American Airlines
Sep 12
PDX9:44 pmPortland
7h 46m
1 stop
TYS8:30 amKnoxville McGhee Tyson
Sep 22
TYS6:00 amKnoxville McGhee Tyson
10h 35m
2 stops
PDX1:35 pmPortland
$374
American Airlines
Sep 12
PDX9:44 pmPortland
7h 46m
1 stop
TYS8:30 amKnoxville McGhee Tyson
Sep 22
TYS6:00 amKnoxville McGhee Tyson
10h 35m
2 stops
PDX1:35 pmPortland
$383

United Airlines flights from Portland to Knoxville

Our best United Airlines deals on Portland to Knoxville flight tickets
United Airlines
Aug 18
PDX7:17 amPortland
6h 41m
1 stop
TYS4:58 pmKnoxville McGhee Tyson
Aug 25
TYS7:15 amKnoxville McGhee Tyson
10h 51m
2 stops
PDX3:06 pmPortland
$360
United Airlines
Aug 4
PDX5:15 amPortland
14h 04m
2 stops
TYS10:19 pmKnoxville McGhee Tyson
Aug 11
TYS9:45 amKnoxville McGhee Tyson
12h 08m
2 stops
PDX6:53 pmPortland
$658
United Airlines
Aug 4
PDX5:15 amPortland
14h 04m
2 stops
TYS10:19 pmKnoxville McGhee Tyson
Aug 11
TYS9:45 amKnoxville McGhee Tyson
12h 08m
2 stops
PDX6:53 pmPortland
$670

momondo Fare Finder

 
Customize your flight search to find flights from Portland to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 23, 2026.
Use the filters below to find and compare flights from Portland to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 9/2

5:56 pm-1:44 pm

1 stop16h 48m

Knoxville McGhee Tyson

Sun 9/6

7:00 am-5:11 pm

1 stop13h 11m

$290

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 10/21

5:35 pm-1:11 pm

1 stop16h 36m

Knoxville McGhee Tyson

Sun 10/25

6:30 am-4:35 pm

1 stop13h 05m

$313

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 8/26

5:56 pm-1:49 pm

1 stop16h 53m

Knoxville McGhee Tyson

Sun 8/30

7:00 am-5:11 pm

1 stop13h 11m

$329

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 9/19

3:22 pm-1:44 pm

1 stop19h 22m

Knoxville McGhee Tyson

Thu 9/24

7:00 am-4:35 pm

1 stop12h 35m

$341

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 9/19

3:22 pm-1:44 pm

1 stop19h 22m

Knoxville McGhee Tyson

Fri 9/25

1:31 pm-4:35 pm

2 stops30h 04m

$344

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Thu 9/17

3:22 pm-1:27 pm

2 stops19h 05m

Knoxville McGhee Tyson

Thu 9/24

7:00 am-4:35 pm

1 stop12h 35m

$345

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 9/2

5:56 pm-12:02 pm

2 stops15h 06m

Knoxville McGhee Tyson

Sun 9/6

7:00 am-5:11 pm

1 stop13h 11m

$347

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 9/16

3:22 pm-1:44 pm

1 stop19h 22m

Knoxville McGhee Tyson

Mon 9/21

8:00 am-2:27 pm

2 stops33h 27m

$353
Quickest round-trip

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Sat 9/12

6:00 am-4:42 pm

1 stop7h 42m

Knoxville McGhee Tyson

Tue 9/22

2:43 pm-7:20 pm

1 stop7h 37m

$355

PortlandKnoxville

PDX - TYS

PDXTYS

Portland

Wed 9/16

3:22 pm-1:44 pm

1 stop19h 22m

Knoxville McGhee Tyson

Thu 9/24

7:00 am-4:35 pm

1 stop12h 35m

$358

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $380 to $576.
The lowest price recently found on this route was $290.

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Portland, with most prices found around $412. If you aren’t able to travel during the month of August, then book flights to Knoxville from Portland during October instead. Flights to Knoxville in October, while not as cheap as those in August, still average around $413.

How far in advance should I book a flight from Portland to Knoxville?

You are more likely to see cheaper flights to Knoxville from Portland when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $489 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Portland for as low as $399 on momondo.

How have Portland to Knoxville flight prices changed over time?

As of July 2026, prices for Portland to Knoxville flights are approximately 14% more expensive when compared to flights at the same time last year.

When to book flights from Portland to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland to Knoxville (PDX to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland to Knoxville

Fastest flight time

6h 10m

Direct flights

None
The fastest flight from Portland to Knoxville takes 6h 10m
There are no direct flights from Portland to Knoxville. There are no popular flight routes from Portland to Knoxville.
Search flight deals

Frequently asked questions about flying from Portland to Knoxville

  • How far is Portland to Knoxville McGhee Tyson by plane?

    Portland and Knoxville McGhee Tyson are 2108.9 mi apart from one another. A reasonable flight in good conditions will take 6h 10m.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland to Knoxville?

Best airlines flying from Portland to Knoxville

Compare and see reviews for airlines that fly from Portland to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $268Free CancellationRating
7.8
8,479 reviews
Search Delta flights
American AirlinesPriceFrom $304Free CancellationRating
7.1
11,832 reviews
Search American Airlines flights
United AirlinesPriceFrom $329Free CancellationRating
7.4
10,024 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Maryville
Corbin
Alcoa
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Clinton
Dandridge
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Flights from Portland to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Portland to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Portland. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Knoxville, momondo offers a useful price alert feature which will track prices for flights to Knoxville from Portland and alert you when they change.

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