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Cheap flights from Portland, Maine to Knoxville from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Knoxville departing on 8/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Portland, Maine to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:30 am - 10:43 am
PWM
-
TYS
5h 13m
1 stop
American Airlines Logo
6:57 am - 2:21 pm
TYS
-
PWM
7h 24m
1 stop
$291American Airlines
Thu, Aug 27 - Mon, Aug 31
Delta Logo
6:25 am - 10:58 am
PWM
-
TYS
4h 33m
1 stop
Delta Logo
5:35 pm - 11:30 pm
TYS
-
PWM
5h 55m
1 stop
$295Delta
Tue, Jul 14 - Wed, Jul 22
Southwest Logo
5:30 am - 12:05 pm
PWM
-
TYS
6h 35m
2 stops
Southwest Logo
12:45 pm - 11:00 pm
TYS
-
PWM
10h 15m
2 stops
$305Southwest
Wed, Jul 22 - Wed, Jul 29
Southwest Logo
5:30 am - 12:05 pm
PWM
-
TYS
6h 35m
2 stops
Southwest Logo
8:10 am - 6:30 pm
TYS
-
PWM
10h 20m
1 stop
$306Southwest
Wed, Jul 22 - Wed, Jul 29
American Airlines Logo
8:01 am - 3:10 pm
PWM
-
TYS
7h 09m
1 stop
American Airlines Logo
6:30 pm - 11:51 pm
TYS
-
PWM
5h 21m
1 stop
$307American Airlines
Mon, Oct 19 - Sat, Oct 24
American Airlines Logo
6:00 am - 10:48 am
PWM
-
TYS
4h 48m
1 stop
American Airlines Logo
5:08 pm - 11:37 pm
TYS
-
PWM
6h 29m
1 stop
$310American Airlines
Mon, Oct 19 - Sat, Oct 24
Delta Logo
6:05 am - 11:11 am
PWM
-
TYS
5h 06m
1 stop
Delta Logo
8:35 am - 1:07 pm
TYS
-
PWM
4h 32m
1 stop
$319Delta
Thu, Aug 27 - Mon, Aug 31
American Airlines Logo
10:28 am - 3:35 pm
PWM
-
TYS
5h 07m
1 stop
American Airlines Logo
4:46 pm - 9:56 pm
TYS
-
PWM
5h 10m
1 stop
$326American Airlines
Fri, Sep 11 - Wed, Sep 16
American Airlines Logo
6:01 pm - 11:51 pm
PWM
-
TYS
5h 50m
1 stop
American Airlines Logo
7:00 am - 12:11 pm
TYS
-
PWM
5h 11m
1 stop
$327American Airlines
Wed, Jul 22 - Wed, Jul 29
Southwest Logo
3:40 pm - 7:55 pm
PWM
-
TYS
4h 15m
1 stop
Southwest Logo
12:45 pm - 10:05 pm
TYS
-
PWM
9h 20m
2 stops
$331Southwest
Fri, Sep 11 - Wed, Sep 16

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United Airlines flights from Portland, Maine to Knoxville

Our best United Airlines deals on Portland, Maine to Knoxville flight tickets
United Airlines
Jul 25
PWM5:15 amPortland
5h 27m
1 stop
TYS10:42 amKnoxville McGhee Tyson
Aug 1
TYS7:19 pmKnoxville McGhee Tyson
4h 32m
1 stop
PWM11:51 pmPortland
$355
United Airlines
Nov 17
PWM9:46 amPortland
4h 57m
1 stop
TYS2:43 pmKnoxville McGhee Tyson
Nov 18
TYS7:00 amKnoxville McGhee Tyson
7h 20m
1 stop
PWM2:20 pmPortland
$375
United Airlines
Aug 27
PWM7:35 pmPortland
4h 24m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Aug 31
TYS7:00 amKnoxville McGhee Tyson
7h 38m
2 stops
PWM2:38 pmPortland
$376

American Airlines flights from Portland, Maine to Knoxville

Our best American Airlines deals on Portland, Maine to Knoxville flight tickets
American Airlines
Aug 27
PWM5:30 amPortland
5h 13m
1 stop
TYS10:43 amKnoxville McGhee Tyson
Aug 31
TYS6:57 amKnoxville McGhee Tyson
7h 24m
1 stop
PWM2:21 pmPortland
$291
American Airlines
Oct 19
PWM8:01 amPortland
7h 09m
1 stop
TYS3:10 pmKnoxville McGhee Tyson
Oct 24
TYS6:30 pmKnoxville McGhee Tyson
5h 21m
1 stop
PWM11:51 pmPortland
$307
American Airlines
Oct 19
PWM6:00 amPortland
4h 48m
1 stop
TYS10:48 amKnoxville McGhee Tyson
Oct 24
TYS5:08 pmKnoxville McGhee Tyson
6h 29m
1 stop
PWM11:37 pmPortland
$310

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Portland, Maine to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 8/27

5:30 am-10:43 am

1 stop5h 13m

Knoxville McGhee Tyson

Mon 8/31

6:57 am-2:21 pm

1 stop7h 24m

$291

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 7/14

6:25 am-10:58 am

1 stop4h 33m

Knoxville McGhee Tyson

Wed 7/22

5:35 pm-11:30 pm

1 stop5h 55m

$295

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 7/22

5:30 am-12:05 pm

2 stops6h 35m

Knoxville McGhee Tyson

Wed 7/29

12:45 pm-11:00 pm

2 stops10h 15m

$305

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 7/22

5:30 am-12:05 pm

2 stops6h 35m

Knoxville McGhee Tyson

Wed 7/29

8:10 am-6:30 pm

1 stop10h 20m

$306

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 10/19

8:01 am-3:10 pm

1 stop7h 09m

Knoxville McGhee Tyson

Sat 10/24

6:30 pm-11:51 pm

1 stop5h 21m

$307

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 10/19

6:00 am-10:48 am

1 stop4h 48m

Knoxville McGhee Tyson

Sat 10/24

5:08 pm-11:37 pm

1 stop6h 29m

$310
Quickest round-trip

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 8/27

6:05 am-11:11 am

1 stop5h 06m

Knoxville McGhee Tyson

Mon 8/31

8:35 am-1:07 pm

1 stop4h 32m

$319

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 9/11

10:28 am-3:35 pm

1 stop5h 07m

Knoxville McGhee Tyson

Wed 9/16

4:46 pm-9:56 pm

1 stop5h 10m

$326

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 7/22

6:01 pm-11:51 pm

1 stop5h 50m

Knoxville McGhee Tyson

Wed 7/29

7:00 am-12:11 pm

1 stop5h 11m

$327

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 9/11

3:40 pm-7:55 pm

1 stop4h 15m

Knoxville McGhee Tyson

Wed 9/16

12:45 pm-10:05 pm

2 stops9h 20m

$331

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland, Maine to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland, Maine and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Portland, Maine, with most prices found around $285. If you aren’t able to travel during the month of January, then book flights to Knoxville from Portland, Maine during August instead. Flights to Knoxville in August, while not as cheap as those in January, still average around $313.

When to book flights from Portland, Maine to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Knoxville (PWM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Knoxville

Fastest flight time

4h 28m

Direct flights

None
The fastest flight from Portland, Maine to Knoxville takes 4h 28m
There are no direct flights from Portland, Maine to Knoxville. There are no popular flight routes from Portland, Maine to Knoxville.
Search flight deals

Frequently asked questions about flying from Portland, Maine to Knoxville

  • How far is Portland to Knoxville McGhee Tyson by plane?

    There are 897.0 mi between Portland and Knoxville McGhee Tyson. 4h 28m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Portland, Maine to Knoxville?

Best airlines flying from Portland, Maine to Knoxville

Compare and see reviews for airlines that fly from Portland, Maine to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,779 reviews
Search American Airlines flights
DeltaPriceFrom $278Free CancellationRating
7.8
8,451 reviews
Search Delta flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
9,896 reviews
Search United Airlines flights
SouthwestPriceFrom $293Free CancellationRating
7.9
4,246 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Portland with this policy.

How can momondo help me find flights from Portland to Knoxville?

momondo helps you find the best flight between Portland and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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