Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Portland, Maine to Knoxville from $148

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Knoxville departing on 5/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Portland, Maine to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
6:10 am - 5:10 pm
PWM
-
TYS
11h 00m
2 stops
Southwest Logo
12:50 pm - 10:35 pm
TYS
-
PWM
9h 45m
2 stops
$305Southwest
Wed, May 13 - Wed, May 20
Multiple Airlines Logo
6:19 pm - 8:23 am
PWM
-
TYS
14h 04m
1 stop
Multiple Airlines Logo
11:27 am - 9:07 am
TYS
-
PWM
21h 40m
2 stops
$318Multiple Airlines
Sun, Mar 29 - Thu, Apr 9
American Airlines Logo
6:01 am - 1:18 pm
PWM
-
TYS
7h 17m
1 stop
American Airlines Logo
6:30 pm - 11:51 pm
TYS
-
PWM
5h 21m
1 stop
$319American Airlines
Tue, Aug 4 - Fri, Aug 7
Southwest Logo
5:30 am - 5:00 pm
PWM
-
TYS
11h 30m
2 stops
Southwest Logo
8:10 am - 6:30 pm
TYS
-
PWM
10h 20m
1 stop
$330Southwest
Tue, Jun 30 - Wed, Jul 15
United Airlines Logo
4:28 pm - 11:08 pm
PWM
-
TYS
6h 40m
1 stop
United Airlines Logo
7:18 pm - 11:59 pm
TYS
-
PWM
4h 41m
1 stop
$332United Airlines
Wed, Apr 29 - Sat, May 2
Multiple Airlines Logo
6:19 pm - 8:23 am
PWM
-
TYS
14h 04m
1 stop
Multiple Airlines Logo
2:56 pm - 10:17 am
TYS
-
PWM
19h 21m
2 stops
$335Multiple Airlines
Sun, Mar 29 - Tue, Apr 7
Southwest Logo
3:55 pm - 8:50 pm
PWM
-
TYS
4h 55m
1 stop
Southwest Logo
12:45 pm - 12:05 am
TYS
-
PWM
11h 20m
2 stops
$337Southwest
Wed, Jun 3 - Sun, Jun 7
Delta Logo
6:50 pm - 11:46 pm
PWM
-
TYS
4h 56m
1 stop
Delta Logo
6:10 am - 1:21 pm
TYS
-
PWM
7h 11m
1 stop
$338Delta
Fri, Jul 31 - Mon, Aug 3
Delta Logo
5:23 am - 11:17 am
PWM
-
TYS
5h 54m
1 stop
Delta Logo
5:30 pm - 11:24 pm
TYS
-
PWM
5h 54m
1 stop
$339Delta
Wed, Apr 8 - Tue, Apr 21
Southwest Logo
3:45 pm - 9:15 pm
PWM
-
TYS
5h 30m
1 stop
Southwest Logo
8:00 am - 5:00 pm
TYS
-
PWM
9h 00m
1 stop
$341Southwest
Tue, Jun 9 - Sun, Jun 14

Southwest flights from Portland, Maine to Knoxville

Our best Southwest deals on Portland, Maine to Knoxville flight tickets
Southwest
May 13
PWM6:10 amPortland
11h 00m
2 stops
TYS5:10 pmKnoxville McGhee Tyson
May 20
TYS12:50 pmKnoxville McGhee Tyson
9h 45m
2 stops
PWM10:35 pmPortland
$305
Southwest
Jun 30
PWM5:30 amPortland
11h 30m
2 stops
TYS5:00 pmKnoxville McGhee Tyson
Jul 15
TYS8:10 amKnoxville McGhee Tyson
10h 20m
1 stop
PWM6:30 pmPortland
$330
Southwest
Jun 3
PWM3:55 pmPortland
4h 55m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
Jun 7
TYS12:45 pmKnoxville McGhee Tyson
11h 20m
2 stops
PWM12:05 amPortland
$337

Delta flights from Portland, Maine to Knoxville

Our best Delta deals on Portland, Maine to Knoxville flight tickets
Delta
Jul 31
PWM6:50 pmPortland
4h 56m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Aug 3
TYS6:10 amKnoxville McGhee Tyson
7h 11m
1 stop
PWM1:21 pmPortland
$338
Delta
Apr 8
PWM5:23 amPortland
5h 54m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Apr 21
TYS5:30 pmKnoxville McGhee Tyson
5h 54m
1 stop
PWM11:24 pmPortland
$339
Delta
Apr 13
PWM5:21 amPortland
5h 56m
1 stop
TYS11:17 amKnoxville McGhee Tyson
Apr 28
TYS6:05 amKnoxville McGhee Tyson
4h 57m
1 stop
PWM11:02 amPortland
$364

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Portland, Maine to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 5/13

6:10 am-5:10 pm

2 stops11h 00m

Knoxville McGhee Tyson

Wed 5/20

12:50 pm-10:35 pm

2 stops9h 45m

$305

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sun 3/29

6:19 pm-8:23 am

1 stop14h 04m

Knoxville McGhee Tyson

Thu 4/9

11:27 am-9:07 am

2 stops21h 40m

$318

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 8/4

6:01 am-1:18 pm

1 stop7h 17m

Knoxville McGhee Tyson

Fri 8/7

6:30 pm-11:51 pm

1 stop5h 21m

$319

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 6/30

5:30 am-5:00 pm

2 stops11h 30m

Knoxville McGhee Tyson

Wed 7/15

8:10 am-6:30 pm

1 stop10h 20m

$330
Quickest round-trip

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 4/29

4:28 pm-11:08 pm

1 stop6h 40m

Knoxville McGhee Tyson

Sat 5/2

7:18 pm-11:59 pm

1 stop4h 41m

$332

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sun 3/29

6:19 pm-8:23 am

1 stop14h 04m

Knoxville McGhee Tyson

Tue 4/7

2:56 pm-10:17 am

2 stops19h 21m

$335

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 6/3

3:55 pm-8:50 pm

1 stop4h 55m

Knoxville McGhee Tyson

Sun 6/7

12:45 pm-12:05 am

2 stops11h 20m

$337

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 7/31

6:50 pm-11:46 pm

1 stop4h 56m

Knoxville McGhee Tyson

Mon 8/3

6:10 am-1:21 pm

1 stop7h 11m

$338

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 4/8

5:23 am-11:17 am

1 stop5h 54m

Knoxville McGhee Tyson

Tue 4/21

5:30 pm-11:24 pm

1 stop5h 54m

$339

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 6/9

3:45 pm-9:15 pm

1 stop5h 30m

Knoxville McGhee Tyson

Sun 6/14

8:00 am-5:00 pm

1 stop9h 00m

$341

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland, Maine to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Portland, Maine, with most prices found around $285. If you aren’t able to travel during the month of January, then book flights to Knoxville from Portland, Maine during August instead. Flights to Knoxville in August, while not as cheap as those in January, still average around $288.

How have Portland, Maine to Knoxville flight prices changed over time?

As of March 2026, prices for Portland, Maine to Knoxville flights are approximately 4% more expensive when compared to flights at the same time last year.

When to book flights from Portland, Maine to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Knoxville (PWM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Knoxville

Fastest flight time

4h 30m

Direct flights

None
The fastest flight from Portland, Maine to Knoxville takes 4h 30m
There are no direct flights from Portland, Maine to Knoxville. There are no popular flight routes from Portland, Maine to Knoxville.
Search flight deals

  • How far is Portland to Knoxville McGhee Tyson by plane?

    There are 897.0 mi between Portland and Knoxville McGhee Tyson. 4h 30m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Portland, Maine to Knoxville?

Best airlines flying from Portland, Maine to Knoxville

Compare and see reviews for airlines that fly from Portland, Maine to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,467 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,296 reviews
Search Delta flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
9,428 reviews
Search United Airlines flights
SouthwestPriceFrom $293Free CancellationRating
8.0
4,318 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Portland with this policy.

How can momondo help me find flights from Portland to Knoxville?

momondo helps you find the best flight between Portland and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 4/15
Wed 4/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States