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Cheap flights from Portland, Maine to Knoxville from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Knoxville departing on 9/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Portland, Maine to Knoxville (PWM-TYS)

Cheap round-trip flights

American Airlines Logo
6:00 am - 10:37 amPWM-TYS
4h 37m1 stop
American Airlines Logo
4:28 pm - 11:37 pmTYS-PWM
7h 09m1 stop
$259American Airlines
Find Deal
Wed, Sep 10 - Thu, Sep 18
American Airlines Logo
1:02 pm - 6:50 pmPWM-TYS
5h 48m2 stops
American Airlines Logo
6:10 pm - 11:05 pmTYS-PWM
4h 55m1 stop
$264American Airlines
Find Deal
Wed, Sep 10 - Thu, Sep 18
American Airlines Logo
4:05 pm - 8:55 pmPWM-TYS
4h 50m1 stop
American Airlines Logo
6:00 am - 12:30 pmTYS-PWM
6h 30m1 stop
$274American Airlines
Find Deal
Thu, Aug 21 - Mon, Aug 25
American Airlines Logo
6:00 am - 12:17 pmPWM-TYS
6h 17m2 stops
American Airlines Logo
6:00 am - 12:30 pmTYS-PWM
6h 30m1 stop
$279American Airlines
Find Deal
Thu, Aug 21 - Mon, Aug 25
United Airlines Logo
6:14 am - 1:25 pmPWM-TYS
7h 11m1 stop
United Airlines Logo
7:00 am - 2:26 pmTYS-PWM
7h 26m1 stop
$359United Airlines
Find Deal
Wed, Aug 20 - Sun, Aug 24
Delta Logo
6:00 am - 5:03 pmPWM-TYS
11h 03m2 stops
Delta Logo
12:25 pm - 12:11 amTYS-PWM
11h 46m2 stops
$369Delta
Find Deal
Thu, Sep 11 - Wed, Sep 17
Delta Logo
6:00 am - 1:08 pmPWM-TYS
7h 08m2 stops
Delta Logo
1:52 pm - 12:34 amTYS-PWM
10h 42m2 stops
$455Delta
Find Deal
Wed, Sep 10 - Thu, Sep 18
United Airlines Logo
4:56 pm - 10:37 pmPWM-TYS
5h 41m1 stop
United Airlines Logo
5:45 am - 12:54 pmTYS-PWM
7h 09m2 stops
$463United Airlines
Find Deal
Wed, Aug 20 - Sun, Aug 24
Logo
6:05 pm - 2:32 pmPWM-TYS
20h 27m2 stops
Logo
10:54 am - 11:44 amTYS-PWM
24h 50m3 stops
$563
Find Deal
Mon, Aug 25 - Wed, Aug 27
Logo
6:05 pm - 2:32 pmPWM-TYS
20h 27m2 stops
Logo
4:39 pm - 11:28 amTYS-PWM
18h 49m2 stops
$583
Find Deal
Mon, Aug 25 - Thu, Aug 28

American Airlines flights from Portland, Maine to Knoxville

Our best American Airlines deals on Portland, Maine to Knoxville flight tickets
American Airlines
Sep 10
PWM6:00 amPortland
4h 37m
1 stop
TYS10:37 amKnoxville McGhee Tyson
Sep 18
TYS4:28 pmKnoxville McGhee Tyson
7h 09m
1 stop
PWM11:37 pmPortland
$259
Find similar
American Airlines
Sep 10
PWM1:02 pmPortland
5h 48m
2 stops
TYS6:50 pmKnoxville McGhee Tyson
Sep 18
TYS6:10 pmKnoxville McGhee Tyson
4h 55m
1 stop
PWM11:05 pmPortland
$264
Find similar
American Airlines
Aug 21
PWM4:05 pmPortland
4h 50m
1 stop
TYS8:55 pmKnoxville McGhee Tyson
Aug 25
TYS6:00 amKnoxville McGhee Tyson
6h 30m
1 stop
PWM12:30 pmPortland
$274
Find similar

United Airlines flights from Portland, Maine to Knoxville

Our best United Airlines deals on Portland, Maine to Knoxville flight tickets
United Airlines
Aug 20
PWM6:14 amPortland
7h 11m
1 stop
TYS1:25 pmKnoxville McGhee Tyson
Aug 24
TYS7:00 amKnoxville McGhee Tyson
7h 26m
1 stop
PWM2:26 pmPortland
$359
Find similar
United Airlines
Aug 20
PWM4:56 pmPortland
5h 41m
1 stop
TYS10:37 pmKnoxville McGhee Tyson
Aug 24
TYS5:45 amKnoxville McGhee Tyson
7h 09m
2 stops
PWM12:54 pmPortland
$463
Find similar
United Airlines
Aug 19
PWM6:00 amPortland
11h 00m
2 stops
TYS5:00 pmKnoxville McGhee Tyson
Aug 24
TYS5:45 amKnoxville McGhee Tyson
7h 09m
2 stops
PWM12:54 pmPortland
$485
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2025.
Use the filters below to find and compare flights from Portland, Maine to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 9/10

6:00 am-10:37 am

1 stop4h 37m

Knoxville McGhee Tyson

Thu 9/18

4:28 pm-11:37 pm

1 stop7h 09m

$259

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 9/10

1:02 pm-6:50 pm

2 stops5h 48m

Knoxville McGhee Tyson

Thu 9/18

6:10 pm-11:05 pm

1 stop4h 55m

$264

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 8/21

4:05 pm-8:55 pm

1 stop4h 50m

Knoxville McGhee Tyson

Mon 8/25

6:00 am-12:30 pm

1 stop6h 30m

$274

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 8/21

6:00 am-12:17 pm

2 stops6h 17m

Knoxville McGhee Tyson

Mon 8/25

6:00 am-12:30 pm

1 stop6h 30m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 8/20

6:14 am-1:25 pm

1 stop7h 11m

Knoxville McGhee Tyson

Sun 8/24

7:00 am-2:26 pm

1 stop7h 26m

$359

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 9/11

6:00 am-5:03 pm

2 stops11h 03m

Knoxville McGhee Tyson

Wed 9/17

12:25 pm-12:11 am

2 stops11h 46m

$369

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 9/10

6:00 am-1:08 pm

2 stops7h 08m

Knoxville McGhee Tyson

Thu 9/18

1:52 pm-12:34 am

2 stops10h 42m

$455

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Wed 8/20

4:56 pm-10:37 pm

1 stop5h 41m

Knoxville McGhee Tyson

Sun 8/24

5:45 am-12:54 pm

2 stops7h 09m

$463

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 8/25

6:05 pm-2:32 pm

2 stops20h 27m

Knoxville McGhee Tyson

Wed 8/27

10:54 am-11:44 am

3 stops24h 50m

$563

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 8/25

6:05 pm-2:32 pm

2 stops20h 27m

Knoxville McGhee Tyson

Thu 8/28

4:39 pm-11:28 am

2 stops18h 49m

$583

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland, Maine to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Portland, Maine, with most prices found around $303. If you aren’t able to travel during the month of September, then book flights to Knoxville from Portland, Maine during December instead. Flights to Knoxville in December, while not as cheap as those in September, still average around $303.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Portland, Maine to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $295. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Portland, Maine to Knoxville for around $694.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Portland, Maine to Knoxville when you can find flight prices for as low as $337. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $373.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Portland, Maine when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $379 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Portland, Maine for as low as $263 on momondo.

When to book flights from Portland, Maine to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Knoxville (PWM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Knoxville

Best Price Found

$170

Fastest flight time

4h 06m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Portland, Maine in the past 72 hours is $170. The best round-trip flight deal from Portland, Maine to Knoxville found on momondo in the last 72 hours is $259.
The fastest flight from Portland, Maine to Knoxville takes 4h 06m
There are no direct flights from Portland, Maine to Knoxville. Popular non-direct route for this connection is Portland Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
Search flight deals

  • How far is Portland to Knoxville McGhee Tyson by plane?

    There are 897.0 mi between Portland and Knoxville McGhee Tyson. 4h 06m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Portland, Maine to Knoxville?

Best airlines flying from Portland, Maine to Knoxville

Compare and see reviews for airlines that fly from Portland, Maine to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $225Free CancellationRating
8.0
7,985 reviews
Search Delta flights
American AirlinesPriceFrom $247Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,916 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Portland with this policy.

How can momondo help me find flights from Portland to Knoxville?

momondo helps you find the best flight between Portland and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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