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Cheap flights from Portland, Maine to Knoxville from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Knoxville departing on 6/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Portland, Maine to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:45 pm - 9:15 pm
PWM
-
TYS
5h 30m
1 stop
Southwest Logo
8:10 am - 12:25 pm
TYS
-
PWM
4h 15m
1 stop
$331Southwest
Tue, Jun 9 - Wed, Jun 10
American Airlines Logo
7:58 am - 1:13 pm
PWM
-
TYS
5h 15m
1 stop
American Airlines Logo
6:00 am - 10:31 am
TYS
-
PWM
4h 31m
1 stop
$335American Airlines
Tue, Jun 30 - Sun, Jul 5
Southwest Logo
3:45 pm - 9:15 pm
PWM
-
TYS
5h 30m
1 stop
Southwest Logo
12:45 pm - 10:55 pm
TYS
-
PWM
10h 10m
2 stops
$336Southwest
Tue, Jun 9 - Wed, Jun 10
American Airlines Logo
7:00 am - 12:56 pm
PWM
-
TYS
5h 56m
1 stop
American Airlines Logo
12:32 pm - 4:43 pm
TYS
-
PWM
4h 11m
1 stop
$339American Airlines
Mon, Oct 19 - Sat, Oct 24
American Airlines Logo
5:58 pm - 11:47 pm
PWM
-
TYS
5h 49m
1 stop
American Airlines Logo
5:00 am - 12:39 pm
TYS
-
PWM
7h 39m
2 stops
$344American Airlines
Mon, Jun 22 - Sun, Jun 28
Delta Logo
6:00 am - 11:05 am
PWM
-
TYS
5h 05m
1 stop
Delta Logo
10:51 am - 4:17 pm
TYS
-
PWM
5h 26m
1 stop
$345Delta
Tue, Jul 7 - Sat, Jul 11
Southwest Logo
5:40 am - 5:40 pm
PWM
-
TYS
12h 00m
2 stops
Southwest Logo
7:00 am - 2:15 pm
TYS
-
PWM
7h 15m
1 stop
$346Southwest
Sat, Aug 22 - Tue, Aug 25
Southwest Logo
5:30 am - 5:00 pm
PWM
-
TYS
11h 30m
2 stops
Southwest Logo
12:45 pm - 10:55 pm
TYS
-
PWM
10h 10m
2 stops
$347Southwest
Tue, Jun 9 - Wed, Jun 10
Delta Logo
6:57 pm - 11:52 pm
PWM
-
TYS
4h 55m
1 stop
Delta Logo
10:51 am - 4:17 pm
TYS
-
PWM
5h 26m
1 stop
$349Delta
Fri, Jul 10 - Sat, Jul 11
Southwest Logo
5:40 am - 5:40 pm
PWM
-
TYS
12h 00m
2 stops
Southwest Logo
12:45 pm - 10:05 pm
TYS
-
PWM
9h 20m
2 stops
$351Southwest
Sat, Aug 22 - Tue, Aug 25

Delta flights from Portland, Maine to Knoxville

Our best Delta deals on Portland, Maine to Knoxville flight tickets
Delta
Jul 7
PWM6:00 amPortland
5h 05m
1 stop
TYS11:05 amKnoxville McGhee Tyson
Jul 11
TYS10:51 amKnoxville McGhee Tyson
5h 26m
1 stop
PWM4:17 pmPortland
$345
Delta
Jul 10
PWM6:57 pmPortland
4h 55m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Jul 11
TYS10:51 amKnoxville McGhee Tyson
5h 26m
1 stop
PWM4:17 pmPortland
$349
Delta
Jul 10
PWM6:00 amPortland
7h 16m
1 stop
TYS1:16 pmKnoxville McGhee Tyson
Jul 10
TYS5:35 pmKnoxville McGhee Tyson
5h 55m
1 stop
PWM11:30 pmPortland
$368

United Airlines flights from Portland, Maine to Knoxville

Our best United Airlines deals on Portland, Maine to Knoxville flight tickets
United Airlines
Sep 1
PWM7:35 pmPortland
4h 22m
1 stop
TYS11:57 pmKnoxville McGhee Tyson
Sep 2
TYS5:45 amKnoxville McGhee Tyson
4h 17m
1 stop
PWM10:02 amPortland
$411
United Airlines
Sep 1
PWM6:00 amPortland
10h 58m
2 stops
TYS4:58 pmKnoxville McGhee Tyson
Sep 2
TYS5:45 amKnoxville McGhee Tyson
4h 17m
1 stop
PWM10:02 amPortland
$416
United Airlines
Sep 1
PWM6:00 amPortland
10h 58m
2 stops
TYS4:58 pmKnoxville McGhee Tyson
Sep 2
TYS5:45 amKnoxville McGhee Tyson
8h 09m
2 stops
PWM1:54 pmPortland
$421

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Portland, Maine to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 6/9

3:45 pm-9:15 pm

1 stop5h 30m

Knoxville McGhee Tyson

Wed 6/10

8:10 am-12:25 pm

1 stop4h 15m

$331

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 6/30

7:58 am-1:13 pm

1 stop5h 15m

Knoxville McGhee Tyson

Sun 7/5

6:00 am-10:31 am

1 stop4h 31m

$335

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 6/9

3:45 pm-9:15 pm

1 stop5h 30m

Knoxville McGhee Tyson

Wed 6/10

12:45 pm-10:55 pm

2 stops10h 10m

$336

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 10/19

7:00 am-12:56 pm

1 stop5h 56m

Knoxville McGhee Tyson

Sat 10/24

12:32 pm-4:43 pm

1 stop4h 11m

$339

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 6/22

5:58 pm-11:47 pm

1 stop5h 49m

Knoxville McGhee Tyson

Sun 6/28

5:00 am-12:39 pm

2 stops7h 39m

$344

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 7/7

6:00 am-11:05 am

1 stop5h 05m

Knoxville McGhee Tyson

Sat 7/11

10:51 am-4:17 pm

1 stop5h 26m

$345

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sat 8/22

5:40 am-5:40 pm

2 stops12h 00m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-2:15 pm

1 stop7h 15m

$346

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Tue 6/9

5:30 am-5:00 pm

2 stops11h 30m

Knoxville McGhee Tyson

Wed 6/10

12:45 pm-10:55 pm

2 stops10h 10m

$347

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 7/10

6:57 pm-11:52 pm

1 stop4h 55m

Knoxville McGhee Tyson

Sat 7/11

10:51 am-4:17 pm

1 stop5h 26m

$349

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sat 8/22

5:40 am-5:40 pm

2 stops12h 00m

Knoxville McGhee Tyson

Tue 8/25

12:45 pm-10:05 pm

2 stops9h 20m

$351

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland, Maine to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland, Maine and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Portland, Maine, with most prices found around $285. If you aren’t able to travel during the month of January, then book flights to Knoxville from Portland, Maine during August instead. Flights to Knoxville in August, while not as cheap as those in January, still average around $288.

When to book flights from Portland, Maine to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Knoxville (PWM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Knoxville

Fastest flight time

4h 24m

Direct flights

None
The fastest flight from Portland, Maine to Knoxville takes 4h 24m
There are no direct flights from Portland, Maine to Knoxville. There are no popular flight routes from Portland, Maine to Knoxville.
Search flight deals

Frequently asked questions about flying from Portland, Maine to Knoxville

  • How far is Portland to Knoxville McGhee Tyson by plane?

    There are 897.0 mi between Portland and Knoxville McGhee Tyson. 4h 24m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Portland, Maine to Knoxville?

Best airlines flying from Portland, Maine to Knoxville

Compare and see reviews for airlines that fly from Portland, Maine to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $258Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,455 reviews
Search Delta flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
9,694 reviews
Search United Airlines flights
SouthwestPriceFrom $293Free CancellationRating
8.0
4,304 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Portland with this policy.

How can momondo help me find flights from Portland to Knoxville?

momondo helps you find the best flight between Portland and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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