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Cheap flights from Portland, Maine to Knoxville from $126

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Knoxville departing on 9/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Portland, Maine to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:59 pm - 9:04 pmPWM  Portland-TYS Knoxville McGhee Tyson
7h 05m1 stop New York LaGuardia
Delta Logo
6:13 pm - 11:28 pmTYS  Knoxville McGhee Tyson-PWM Portland
5h 15m1 stop Atlanta Hartsfield-Jackson
$251Delta
Wed, Sep 23 - Tue, Sep 29
Delta Logo
12:50 pm - 5:59 pmPWM  Portland-TYS Knoxville McGhee Tyson
5h 09m1 stop Detroit Metropolitan Wayne County
Delta Logo
11:43 am - 3:58 pmTYS  Knoxville McGhee Tyson-PWM Portland
4h 15m1 stop Detroit Metropolitan Wayne County
$251Delta
Thu, Nov 12 - Mon, Nov 16
American Airlines Logo
6:00 am - 10:33 amPWM  Portland-TYS Knoxville McGhee Tyson
4h 33m1 stop Philadelphia
American Airlines Logo
6:05 pm - 11:36 pmTYS  Knoxville McGhee Tyson-PWM Portland
5h 31m1 stop Philadelphia
$281American Airlines
Thu, Oct 8 - Wed, Oct 14
American Airlines Logo
6:02 am - 10:45 amPWM  Portland-TYS Knoxville McGhee Tyson
4h 43m1 stop Washington, D.C. Reagan-National
American Airlines Logo
5:15 am - 12:40 pmTYS  Knoxville McGhee Tyson-PWM Portland
7h 25m1 stop Charlotte Douglas
$299American Airlines
Thu, Aug 27 - Mon, Aug 31
United Airlines Logo
5:50 am - 10:49 amPWM  Portland-TYS Knoxville McGhee Tyson
4h 59m1 stop Newark
United Airlines Logo
7:35 pm - 11:59 pmTYS  Knoxville McGhee Tyson-PWM Portland
4h 24m1 stop Washington, D.C. Dulles Intl
$321United Airlines
Fri, Nov 13 - Mon, Nov 16
Southwest Logo
11:10 am - 8:30 pmPWM  Portland-TYS Knoxville McGhee Tyson
9h 20m2 stops Baltimore/Washington Nashville Intl
Southwest Logo
7:55 am - 12:10 pmTYS  Knoxville McGhee Tyson-PWM Portland
4h 15m1 stop Baltimore/Washington
$324Southwest
Thu, Nov 12 - Mon, Nov 16
Southwest Logo
5:20 am - 4:50 pmPWM  Portland-TYS Knoxville McGhee Tyson
11h 30m2 stops Baltimore/Washington Orlando
Southwest Logo
8:15 am - 2:45 pmTYS  Knoxville McGhee Tyson-PWM Portland
6h 30m1 stop Baltimore/Washington
$324Southwest
Sun, Nov 1 - Sat, Nov 14
United Airlines Logo
6:03 am - 1:18 pmPWM  Portland-TYS Knoxville McGhee Tyson
7h 15m1 stop Chicago O'Hare Intl
United Airlines Logo
1:53 pm - 9:23 pmTYS  Knoxville McGhee Tyson-PWM Portland
7h 30m1 stop Chicago O'Hare Intl
$331United Airlines
Sun, Sep 6 - Sat, Sep 12
Multiple Airlines Logo
5:09 pm - 7:43 amPWM  Portland-TYS Knoxville McGhee Tyson
14h 34m2 stops Raleigh-Durham Tampa
Multiple Airlines Logo
7:00 am - 9:08 amTYS  Knoxville McGhee Tyson-PWM Portland
26h 08m1 stop Orlando Sanford Intl
$384Multiple Airlines
Wed, Oct 21 - Sun, Oct 25
Multiple Airlines Logo
9:52 am - 7:05 pmPWM  Portland-TYS Knoxville McGhee Tyson
9h 13m1 stop Orlando
Multiple Airlines Logo
2:49 pm - 9:19 pmTYS  Knoxville McGhee Tyson-PWM Portland
30h 30m2 stops Orlando Charleston
$386Multiple Airlines
Fri, Aug 28 - Mon, Aug 31

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American Airlines flights from Portland, Maine to Knoxville

Our best American Airlines deals on Portland, Maine to Knoxville flight tickets
American Airlines
Oct 8
PWM6:00 amPortland
4h 33m
1 stop
TYS10:33 amKnoxville McGhee Tyson
Oct 14
TYS6:05 pmKnoxville McGhee Tyson
5h 31m
1 stop
PWM11:36 pmPortland
$281
American Airlines
Sep 16
PWM5:30 amPortland
6h 13m
1 stop
TYS11:43 amKnoxville McGhee Tyson
Sep 21
TYS6:11 pmKnoxville McGhee Tyson
5h 25m
1 stop
PWM11:36 pmPortland
$301
American Airlines
Nov 1
PWM6:00 amPortland
5h 12m
1 stop
TYS11:12 amKnoxville McGhee Tyson
Nov 14
TYS12:42 pmKnoxville McGhee Tyson
5h 35m
1 stop
PWM6:17 pmPortland
$319

Southwest flights from Portland, Maine to Knoxville

Our best Southwest deals on Portland, Maine to Knoxville flight tickets
Southwest
Nov 1
PWM5:20 amPortland
11h 30m
2 stops
TYS4:50 pmKnoxville McGhee Tyson
Nov 14
TYS8:15 amKnoxville McGhee Tyson
6h 30m
1 stop
PWM2:45 pmPortland
$324
Southwest
Nov 12
PWM5:20 amPortland
11h 30m
2 stops
TYS4:50 pmKnoxville McGhee Tyson
Nov 16
TYS7:55 amKnoxville McGhee Tyson
6h 50m
1 stop
PWM2:45 pmPortland
$326
Southwest
Nov 13
PWM11:10 amPortland
9h 20m
2 stops
TYS8:30 pmKnoxville McGhee Tyson
Nov 16
TYS7:55 amKnoxville McGhee Tyson
4h 15m
1 stop
PWM12:10 pmPortland
$348

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Portland, Maine to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Wed 9/23

1:59 pm-9:04 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 9/29

6:13 pm-11:28 pm

1 stop5h 15m

$251

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Thu 11/12

12:50 pm-5:59 pm

1 stop5h 09m

Knoxville McGhee Tyson

Mon 11/16

11:43 am-3:58 pm

1 stop4h 15m

$251

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Thu 10/8

6:00 am-10:33 am

1 stop4h 33m

Knoxville McGhee Tyson

Wed 10/14

6:05 pm-11:36 pm

1 stop5h 31m

$281

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Thu 8/27

6:02 am-10:45 am

1 stop4h 43m

Knoxville McGhee Tyson

Mon 8/31

5:15 am-12:40 pm

1 stop7h 25m

$299
Quickest round-trip

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Fri 11/13

5:50 am-10:49 am

1 stop4h 59m

Knoxville McGhee Tyson

Mon 11/16

7:35 pm-11:59 pm

1 stop4h 24m

$321

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Thu 11/12

11:10 am-8:30 pm

2 stops9h 20m

Knoxville McGhee Tyson

Mon 11/16

7:55 am-12:10 pm

1 stop4h 15m

$324

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Sun 11/1

5:20 am-4:50 pm

2 stops11h 30m

Knoxville McGhee Tyson

Sat 11/14

8:15 am-2:45 pm

1 stop6h 30m

$324

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Sun 9/6

6:03 am-1:18 pm

1 stop7h 15m

Knoxville McGhee Tyson

Sat 9/12

1:53 pm-9:23 pm

1 stop7h 30m

$331

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Wed 10/21

5:09 pm-7:43 am

2 stops14h 34m

Knoxville McGhee Tyson

Sun 10/25

7:00 am-9:08 am

1 stop26h 08m

$384

PortlandKnoxville

PWM Portland - TYS Knoxville McGhee Tyson

PWMTYS

Portland

Fri 8/28

9:52 am-7:05 pm

1 stop9h 13m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-9:19 pm

2 stops30h 30m

$386

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland, Maine to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Portland, Maine, with most prices found around $285. If you aren’t able to travel during the month of January, then book flights to Knoxville from Portland, Maine during August instead. Flights to Knoxville in August, while not as cheap as those in January, still average around $313.

When to book flights from Portland, Maine to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Knoxville (PWM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Knoxville

Fastest flight time

5h 09m

Direct flights

None
The fastest flight from Portland, Maine to Knoxville takes 5h 09m
There are no direct flights from Portland, Maine to Knoxville. There are no popular flight routes from Portland, Maine to Knoxville.
Search flight deals

Frequently asked questions about flying from Portland, Maine to Knoxville

  • How far is Portland to Knoxville McGhee Tyson by plane?

    There are 897.0 mi between Portland and Knoxville McGhee Tyson. 5h 09m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Portland, Maine to Knoxville?

Best airlines flying from Portland, Maine to Knoxville

Compare and see reviews for airlines that fly from Portland, Maine to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $278Free CancellationRating
7.1
11,902 reviews
Search American Airlines flights
DeltaPriceFrom $278Free CancellationRating
7.8
8,505 reviews
Search Delta flights
United AirlinesPriceFrom $278Free CancellationRating
7.4
10,103 reviews
Search United Airlines flights
SouthwestPriceFrom $293Free CancellationRating
8.0
4,221 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Lenoir City
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Portland with this policy.

How can momondo help me find flights from Portland to Knoxville?

momondo helps you find the best flight between Portland and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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