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Cheap flights from Portland, Maine to Knoxville from $140

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Knoxville departing on 12/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Portland, Maine to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:17 pm - 9:36 pmPWM-TYS
4h 19m1 stop
American Airlines Logo
6:00 am - 11:37 amTYS-PWM
5h 37m1 stop
$279American Airlines
Find Deal
Fri, Dec 5 - Mon, Dec 8
American Airlines Logo
5:46 am - 2:27 pmPWM-TYS
8h 41m2 stops
American Airlines Logo
6:00 am - 11:37 amTYS-PWM
5h 37m1 stop
$284American Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
American Airlines Logo
5:17 pm - 9:36 pmPWM-TYS
4h 19m1 stop
American Airlines Logo
6:00 am - 11:37 amTYS-PWM
5h 37m1 stop
$309American Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
American Airlines Logo
3:52 pm - 9:03 pmPWM-TYS
5h 11m1 stop
American Airlines Logo
4:15 pm - 10:33 pmTYS-PWM
6h 18m1 stop
$329American Airlines
Find Deal
Mon, Nov 17 - Fri, Nov 21
Delta Logo
6:00 am - 2:48 pmPWM-TYS
8h 48m2 stops
Delta Logo
5:26 pm - 11:19 pmTYS-PWM
5h 53m1 stop
$334Delta
Find Deal
Mon, Nov 17 - Wed, Nov 19
Delta Logo
6:00 am - 2:48 pmPWM-TYS
8h 48m2 stops
Delta Logo
5:35 am - 12:08 pmTYS-PWM
6h 33m2 stops
$339Delta
Find Deal
Mon, Nov 17 - Wed, Nov 19
Multiple Airlines Logo
9:46 am - 11:14 pmPWM-TYS
13h 28m1 stop
Multiple Airlines Logo
6:30 am - 9:06 amTYS-PWM
26h 36m2 stops
$409Multiple Airlines
Find Deal
Fri, Nov 14 - Sun, Nov 16
United Airlines Logo
6:00 am - 1:18 pmPWM-TYS
7h 18m1 stop
United Airlines Logo
5:50 am - 1:38 pmTYS-PWM
7h 48m2 stops
$414United Airlines
Find Deal
Sat, Apr 4 - Sat, Apr 11
United Airlines Logo
11:17 am - 7:17 pmPWM-TYS
8h 00m2 stops
United Airlines Logo
5:50 am - 1:38 pmTYS-PWM
7h 48m2 stops
$419United Airlines
Find Deal
Sat, Apr 4 - Sat, Apr 11
Multiple Airlines Logo
9:46 am - 11:14 pmPWM-TYS
13h 28m1 stop
Multiple Airlines Logo
6:58 pm - 9:06 amTYS-PWM
14h 08m1 stop
$428Multiple Airlines
Find Deal
Fri, Nov 14 - Sun, Nov 16

American Airlines flights from Portland, Maine to Knoxville

Our best American Airlines deals on Portland, Maine to Knoxville flight tickets
American Airlines
Dec 5
PWM5:17 pmPortland
4h 19m
1 stop
TYS9:36 pmKnoxville McGhee Tyson
Dec 8
TYS6:00 amKnoxville McGhee Tyson
5h 37m
1 stop
PWM11:37 amPortland
$279
Find similar
American Airlines
Dec 4
PWM5:46 amPortland
8h 41m
2 stops
TYS2:27 pmKnoxville McGhee Tyson
Dec 8
TYS6:00 amKnoxville McGhee Tyson
5h 37m
1 stop
PWM11:37 amPortland
$284
Find similar
American Airlines
Dec 4
PWM5:17 pmPortland
4h 19m
1 stop
TYS9:36 pmKnoxville McGhee Tyson
Dec 8
TYS6:00 amKnoxville McGhee Tyson
5h 37m
1 stop
PWM11:37 amPortland
$309
Find similar

Delta flights from Portland, Maine to Knoxville

Our best Delta deals on Portland, Maine to Knoxville flight tickets
Delta
Nov 17
PWM6:00 amPortland
8h 48m
2 stops
TYS2:48 pmKnoxville McGhee Tyson
Nov 19
TYS5:26 pmKnoxville McGhee Tyson
5h 53m
1 stop
PWM11:19 pmPortland
$334
Find similar
Delta
Nov 17
PWM6:00 amPortland
8h 48m
2 stops
TYS2:48 pmKnoxville McGhee Tyson
Nov 19
TYS5:35 amKnoxville McGhee Tyson
6h 33m
2 stops
PWM12:08 pmPortland
$339
Find similar
Delta
Nov 17
PWM4:40 pmPortland
7h 01m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
Nov 21
TYS5:35 amKnoxville McGhee Tyson
10h 32m
2 stops
PWM4:07 pmPortland
$374
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Portland, Maine to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 12/5

5:17 pm-9:36 pm

1 stop4h 19m

Knoxville McGhee Tyson

Mon 12/8

6:00 am-11:37 am

1 stop5h 37m

$279

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 12/4

5:46 am-2:27 pm

2 stops8h 41m

Knoxville McGhee Tyson

Mon 12/8

6:00 am-11:37 am

1 stop5h 37m

$284

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Thu 12/4

5:17 pm-9:36 pm

1 stop4h 19m

Knoxville McGhee Tyson

Mon 12/8

6:00 am-11:37 am

1 stop5h 37m

$309

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 11/17

3:52 pm-9:03 pm

1 stop5h 11m

Knoxville McGhee Tyson

Fri 11/21

4:15 pm-10:33 pm

1 stop6h 18m

$329

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 11/17

6:00 am-2:48 pm

2 stops8h 48m

Knoxville McGhee Tyson

Wed 11/19

5:26 pm-11:19 pm

1 stop5h 53m

$334

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Mon 11/17

6:00 am-2:48 pm

2 stops8h 48m

Knoxville McGhee Tyson

Wed 11/19

5:35 am-12:08 pm

2 stops6h 33m

$339

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 11/14

9:46 am-11:14 pm

1 stop13h 28m

Knoxville McGhee Tyson

Sun 11/16

6:30 am-9:06 am

2 stops26h 36m

$409

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sat 4/4

6:00 am-1:18 pm

1 stop7h 18m

Knoxville McGhee Tyson

Sat 4/11

5:50 am-1:38 pm

2 stops7h 48m

$414

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Sat 4/4

11:17 am-7:17 pm

2 stops8h 00m

Knoxville McGhee Tyson

Sat 4/11

5:50 am-1:38 pm

2 stops7h 48m

$419

PortlandKnoxville

PWM - TYS

PWMTYS

Portland

Fri 11/14

9:46 am-11:14 pm

1 stop13h 28m

Knoxville McGhee Tyson

Sun 11/16

6:58 pm-9:06 am

1 stop14h 08m

$428

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Portland, Maine to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of December is, on average, the cheapest month to fly to Knoxville from Portland, Maine, with most prices found around $280. If you aren’t able to travel during the month of December, then book flights to Knoxville from Portland, Maine during August instead. Flights to Knoxville in August, while not as cheap as those in December, still average around $288.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Portland, Maine to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $295. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Portland, Maine to Knoxville for around $694.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Portland, Maine to Knoxville when you can find flight prices for as low as $337. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $373.

When to book flights from Portland, Maine to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Knoxville (PWM to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Knoxville

Direct flights

None
There are no direct flights from Portland, Maine to Knoxville. There are no popular flight routes from Portland, Maine to Knoxville.
Search flight deals

  • How far is Portland to Knoxville McGhee Tyson by plane?

    There are 897.0 mi between Portland and Knoxville McGhee Tyson. 4h 19m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Portland Airport to Knoxville McGhee Tyson Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Portland Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Portland Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Portland, Maine to Knoxville?

Best airlines flying from Portland, Maine to Knoxville

Compare and see reviews for airlines that fly from Portland, Maine to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $258Free CancellationRating
7.4
8,997 reviews
Search United Airlines flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
11,034 reviews
Search American Airlines flights
DeltaPriceFrom $258Free CancellationRating
7.9
8,001 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Knoxville?

It is quick and easy to find Portland to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Portland to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Portland with this policy.

How can momondo help me find flights from Portland to Knoxville?

momondo helps you find the best flight between Portland and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Portland to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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