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Cheap flights from Portland, Maine to Florence from $418

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Florence departing on 5/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Portland, Maine to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 3:32 pm
PWM
-
FLO
9h 32m
2 stops
American Airlines Logo
5:05 am - 9:51 am
FLO
-
PWM
4h 46m
1 stop
$534American Airlines
Tue, May 19 - Sat, May 23
American Airlines Logo
6:00 am - 3:32 pm
PWM
-
FLO
9h 32m
2 stops
American Airlines Logo
5:05 am - 2:24 pm
FLO
-
PWM
9h 19m
2 stops
$539American Airlines
Tue, May 19 - Sat, May 23
American Airlines Logo
2:24 pm - 10:00 pm
PWM
-
FLO
7h 36m
1 stop
American Airlines Logo
5:05 am - 2:28 pm
FLO
-
PWM
9h 23m
2 stops
$654American Airlines
Thu, May 21 - Thu, May 28
American Airlines Logo
6:00 am - 2:10 pm
PWM
-
FLO
8h 10m
2 stops
American Airlines Logo
2:35 pm - 9:46 pm
FLO
-
PWM
7h 11m
2 stops
$659American Airlines
Thu, May 21 - Thu, May 28
American Airlines Logo
7:10 am - 10:42 pm
PWM
-
FLO
15h 32m
1 stop
American Airlines Logo
2:35 pm - 10:44 pm
FLO
-
PWM
8h 09m
1 stop
$849American Airlines
Tue, May 19 - Sat, May 23
American Airlines Logo
7:15 am - 2:10 pm
PWM
-
FLO
6h 55m
1 stop
American Airlines Logo
2:35 pm - 10:47 pm
FLO
-
PWM
8h 12m
1 stop
$990American Airlines
Thu, May 21 - Thu, May 28

American Airlines flights from Portland, Maine to Florence, South Carolina

Our best American Airlines deals on Portland, Maine to Florence, South Carolina flight tickets
American Airlines
May 19
PWM6:00 amPortland
9h 32m
2 stops
FLO3:32 pmFlorence
May 23
FLO5:05 amFlorence
4h 46m
1 stop
PWM9:51 amPortland
$534
American Airlines
May 19
PWM6:00 amPortland
9h 32m
2 stops
FLO3:32 pmFlorence
May 23
FLO5:05 amFlorence
9h 19m
2 stops
PWM2:24 pmPortland
$539
American Airlines
May 21
PWM2:24 pmPortland
7h 36m
1 stop
FLO10:00 pmFlorence
May 28
FLO5:05 amFlorence
9h 23m
2 stops
PWM2:28 pmPortland
$654

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 8, 2026.
Use the filters below to find and compare flights from Portland, Maine to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Tue 5/19

6:00 am-3:32 pm

2 stops9h 32m

Florence

Sat 5/23

5:05 am-9:51 am

1 stop4h 46m

$534

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Tue 5/19

6:00 am-3:32 pm

2 stops9h 32m

Florence

Sat 5/23

5:05 am-2:24 pm

2 stops9h 19m

$539

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 5/21

2:24 pm-10:00 pm

1 stop7h 36m

Florence

Thu 5/28

5:05 am-2:28 pm

2 stops9h 23m

$654

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 5/21

6:00 am-2:10 pm

2 stops8h 10m

Florence

Thu 5/28

2:35 pm-9:46 pm

2 stops7h 11m

$659

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Tue 5/19

7:10 am-10:42 pm

1 stop15h 32m

Florence

Sat 5/23

2:35 pm-10:44 pm

1 stop8h 09m

$849

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 5/21

7:15 am-2:10 pm

1 stop6h 55m

Florence

Thu 5/28

2:35 pm-10:47 pm

1 stop8h 12m

$990
Cheapest one-way

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 5/13

6:00 am-3:50 pm

2 stops9h 50m

$418

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 5/14

6:00 am-3:50 pm

2 stops9h 50m

$448
Quickest one-way

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 5/13

7:10 am-3:50 pm

1 stop8h 40m

$819

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Thu 5/14

11:56 am-9:47 pm

1 stop9h 51m

$869

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Portland, Maine to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Portland to Florence?

American Airlines is the most popular carrier operating from Portland to Florence

What airlines fly to Florence, South Carolina?

American Airlines, Spirit Airlines and Delta are the top three most popular airlines that fly to Florence, South Carolina from Portland, Maine according to our data. American Airlines is the first choice among our users, with 44% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 8 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Portland, Maine to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Florence, South Carolina (PWM to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Florence, South Carolina

Fastest flight time

9h 32m

Direct flights

None
The fastest flight from Portland, Maine to Florence, South Carolina takes 9h 32m
There are no direct flights from Portland, Maine to Florence, South Carolina. There are no popular flight routes from Portland, Maine to Florence, South Carolina.
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Frequently asked questions about flying from Portland, Maine to Florence, South Carolina

  • How far is Portland to Florence by plane?

    The straight-line distance from Portland to Florence is 828.2 mi. Typically, this will take 9h 32m by plane in normal conditions.

  • When did momondo last update prices for flights from Portland Airport to Florence Airport?

    Prices for flights from Portland Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Portland Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington
Bennettsville
Lake City

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Portland to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Portland to Florence with flexible booking policies on momondo?

All flight searches from Portland to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Portland to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Portland to Florence.

I’m not ready to book a flight from Portland to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Portland to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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