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Cheap flights from Portland, Maine to Florence from $559

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Florence departing on 12/31. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Portland, Maine to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:48 am - 12:26 pm
PWM
-
FLO
6h 38m2 stops
American Airlines Logo
6:30 pm - 10:51 pm
FLO
-
PWM
4h 21m1 stop
$559American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
5:48 am - 12:26 pm
PWM
-
FLO
6h 38m2 stops
American Airlines Logo
5:15 am - 12:11 pm
FLO
-
PWM
6h 56m2 stops
$564American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
7:17 am - 12:26 pm
PWM
-
FLO
5h 09m1 stop
American Airlines Logo
6:30 pm - 10:51 pm
FLO
-
PWM
4h 21m1 stop
$588American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
8:02 am - 2:10 pm
PWM
-
FLO
6h 08m1 stop
American Airlines Logo
5:13 am - 12:00 pm
FLO
-
PWM
6h 47m2 stops
$693American Airlines
Sat, Apr 18 - Thu, Apr 23
American Airlines Logo
1:15 pm - 11:41 pm
PWM
-
FLO
10h 26m2 stops
American Airlines Logo
5:13 am - 12:00 pm
FLO
-
PWM
6h 47m2 stops
$698American Airlines
Sat, Apr 18 - Thu, Apr 23
American Airlines Logo
8:02 am - 2:10 pm
PWM
-
FLO
6h 08m1 stop
American Airlines Logo
2:33 pm - 10:25 pm
FLO
-
PWM
7h 52m1 stop
$907American Airlines
Sat, Apr 18 - Fri, Apr 24
American Airlines Logo
8:02 am - 2:10 pm
PWM
-
FLO
6h 08m1 stop
American Airlines Logo
5:13 am - 1:27 pm
FLO
-
PWM
8h 14m1 stop
$1,133American Airlines
Sat, Apr 18 - Sat, Apr 25

American Airlines flights from Portland, Maine to Florence, South Carolina

Our best American Airlines deals on Portland, Maine to Florence, South Carolina flight tickets
American Airlines
Dec 31
PWM5:48 amPortland
6h 38m
2 stops
FLO12:26 pmFlorence
Jan 4
FLO6:30 pmFlorence
4h 21m
1 stop
PWM10:51 pmPortland
$559
Find similar
American Airlines
Dec 31
PWM5:48 amPortland
6h 38m
2 stops
FLO12:26 pmFlorence
Jan 4
FLO5:15 amFlorence
6h 56m
2 stops
PWM12:11 pmPortland
$564
Find similar
American Airlines
Dec 31
PWM7:17 amPortland
5h 09m
1 stop
FLO12:26 pmFlorence
Jan 4
FLO6:30 pmFlorence
4h 21m
1 stop
PWM10:51 pmPortland
$588
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Portland, Maine to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 12/31

5:48 am-12:26 pm

2 stops6h 38m

Florence

Sun 1/4

6:30 pm-10:51 pm

1 stop4h 21m

$559

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 12/31

5:48 am-12:26 pm

2 stops6h 38m

Florence

Sun 1/4

5:15 am-12:11 pm

2 stops6h 56m

$564

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Wed 12/31

7:17 am-12:26 pm

1 stop5h 09m

Florence

Sun 1/4

6:30 pm-10:51 pm

1 stop4h 21m

$588

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Sat 4/18

8:02 am-2:10 pm

1 stop6h 08m

Florence

Thu 4/23

5:13 am-12:00 pm

2 stops6h 47m

$693

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Sat 4/18

1:15 pm-11:41 pm

2 stops10h 26m

Florence

Thu 4/23

5:13 am-12:00 pm

2 stops6h 47m

$698

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Sat 4/18

8:02 am-2:10 pm

1 stop6h 08m

Florence

Fri 4/24

2:33 pm-10:25 pm

1 stop7h 52m

$907

PortlandFlorence

PWM - FLO

PWMFLO

Portland

Sat 4/18

8:02 am-2:10 pm

1 stop6h 08m

Florence

Sat 4/25

5:13 am-1:27 pm

1 stop8h 14m

$1,133

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Portland, Maine to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Florence, South Carolina?

On average, the least expensive day to fly to Florence, South Carolina from Portland, Maine is on a Wednesday. momondo users have found tickets for Wednesday departures for as low as $318. However, this price may fluctuate depending on the airline, the season, and holidays. On the other hand, Sunday is the most expensive day to depart from Portland, Maine because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $558.

What is the cheapest time of day to depart on your flight to Florence, South Carolina?

According to our data, the cheapest time of day to fly to Florence, South Carolina is in the afternoon. momondo users have found flights departing from Portland, Maine to Florence, South Carolina in the afternoon for as low as $388. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. In the morning is when there is more demand to fly to Florence, South Carolina, so prices are often more expensive at around $418 per ticket.

When to book flights from Portland, Maine to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Florence, South Carolina (PWM to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Florence, South Carolina

Fastest flight time

6h 38m

Direct flights

None
The fastest flight from Portland, Maine to Florence, South Carolina takes 6h 38m
There are no direct flights from Portland, Maine to Florence, South Carolina. There are no popular flight routes from Portland, Maine to Florence, South Carolina.
Search flight deals

  • How far is Portland to Florence by plane?

    The straight-line distance from Portland to Florence is 828.2 mi. Typically, this will take 6h 38m by plane in normal conditions.

  • When did momondo last update prices for flights from Portland Airport to Florence Airport?

    Prices for flights from Portland Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Portland Airport to Florence Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The travel and health documents required for your trip to Florence Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Florence Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Lake City
Hartsville
Bennettsville
Darlington

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Florence?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Portland to Florence. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Portland to Florence with flexible booking policies on momondo?

All flight searches from Portland to Florence on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Portland to Florence?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Portland to Florence.

I’m not ready to book a flight from Portland to Florence right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Portland to Florence now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Florence and let you know when they change.

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