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Cheap flights from Portland, Maine to Des Moines from $279

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Des Moines departing on 12/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Portland, Maine to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:45 am - 12:28 pm
PWM
-
DSM
7h 43m1 stop
Delta Logo
6:24 am - 12:08 pm
DSM
-
PWM
4h 44m1 stop
$381Delta
Wed, Dec 31 - Tue, Jan 6
Delta Logo
5:45 am - 12:28 pm
PWM
-
DSM
7h 43m1 stop
Delta Logo
1:03 pm - 10:27 pm
DSM
-
PWM
8h 24m1 stop
$382Delta
Wed, Dec 31 - Sat, Jan 10
Delta Logo
5:45 am - 12:28 pm
PWM
-
DSM
7h 43m1 stop
Delta Logo
12:04 pm - 11:22 pm
DSM
-
PWM
10h 18m2 stops
$386Delta
Wed, Dec 31 - Wed, Jan 7
Delta Logo
5:45 am - 12:28 pm
PWM
-
DSM
7h 43m1 stop
Delta Logo
6:24 am - 12:08 pm
DSM
-
PWM
4h 44m1 stop
$393Delta
Wed, Dec 31 - Thu, Jan 8
Delta Logo
5:45 am - 12:28 pm
PWM
-
DSM
7h 43m1 stop
Delta Logo
12:04 pm - 11:22 pm
DSM
-
PWM
10h 18m2 stops
$398Delta
Wed, Dec 31 - Thu, Jan 8
United Airlines Logo
5:30 am - 2:33 pm
PWM
-
DSM
10h 03m2 stops
United Airlines Logo
8:00 am - 6:50 pm
DSM
-
PWM
9h 50m2 stops
$403United Airlines
Thu, Jan 1 - Thu, Jan 8
United Airlines Logo
4:10 pm - 9:50 pm
PWM
-
DSM
6h 40m1 stop
United Airlines Logo
7:50 am - 2:39 pm
DSM
-
PWM
5h 49m1 stop
$416United Airlines
Wed, Jan 7 - Sat, Jan 10
Delta Logo
5:45 am - 12:28 pm
PWM
-
DSM
7h 43m1 stop
Delta Logo
6:24 am - 12:08 pm
DSM
-
PWM
4h 44m1 stop
$417Delta
Wed, Dec 31 - Sun, Jan 11
United Airlines Logo
11:12 am - 9:50 pm
PWM
-
DSM
11h 38m2 stops
United Airlines Logo
7:50 am - 2:39 pm
DSM
-
PWM
5h 49m1 stop
$421United Airlines
Wed, Jan 7 - Sat, Jan 10
United Airlines Logo
11:12 am - 9:50 pm
PWM
-
DSM
11h 38m2 stops
United Airlines Logo
7:50 am - 2:39 pm
DSM
-
PWM
5h 49m1 stop
$422United Airlines
Wed, Jan 7 - Sat, Jan 10

Delta flights from Portland, Maine to Des Moines

Our best Delta deals on Portland, Maine to Des Moines flight tickets
Delta
Dec 31
PWM5:45 amPortland
7h 43m
1 stop
DSM12:28 pmDes Moines
Jan 6
DSM6:24 amDes Moines
4h 44m
1 stop
PWM12:08 pmPortland
$381
Find similar
Delta
Dec 31
PWM5:45 amPortland
7h 43m
1 stop
DSM12:28 pmDes Moines
Jan 10
DSM1:03 pmDes Moines
8h 24m
1 stop
PWM10:27 pmPortland
$382
Find similar
Delta
Dec 31
PWM5:45 amPortland
7h 43m
1 stop
DSM12:28 pmDes Moines
Jan 7
DSM12:04 pmDes Moines
10h 18m
2 stops
PWM11:22 pmPortland
$386
Find similar

United Airlines flights from Portland, Maine to Des Moines

Our best United Airlines deals on Portland, Maine to Des Moines flight tickets
United Airlines
Jan 1
PWM5:30 amPortland
10h 03m
2 stops
DSM2:33 pmDes Moines
Jan 8
DSM8:00 amDes Moines
9h 50m
2 stops
PWM6:50 pmPortland
$403
Find similar
United Airlines
Jan 7
PWM4:10 pmPortland
6h 40m
1 stop
DSM9:50 pmDes Moines
Jan 10
DSM7:50 amDes Moines
5h 49m
1 stop
PWM2:39 pmPortland
$416
Find similar
United Airlines
Jan 7
PWM11:12 amPortland
11h 38m
2 stops
DSM9:50 pmDes Moines
Jan 10
DSM7:50 amDes Moines
5h 49m
1 stop
PWM2:39 pmPortland
$421
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from Portland, Maine to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 12/31

5:45 am-12:28 pm

1 stop7h 43m

Des Moines

Tue 1/6

6:24 am-12:08 pm

1 stop4h 44m

$381

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 12/31

5:45 am-12:28 pm

1 stop7h 43m

Des Moines

Sat 1/10

1:03 pm-10:27 pm

1 stop8h 24m

$382

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 12/31

5:45 am-12:28 pm

1 stop7h 43m

Des Moines

Wed 1/7

12:04 pm-11:22 pm

2 stops10h 18m

$386

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 12/31

5:45 am-12:28 pm

1 stop7h 43m

Des Moines

Thu 1/8

6:24 am-12:08 pm

1 stop4h 44m

$393

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 12/31

5:45 am-12:28 pm

1 stop7h 43m

Des Moines

Thu 1/8

12:04 pm-11:22 pm

2 stops10h 18m

$398

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Thu 1/1

5:30 am-2:33 pm

2 stops10h 03m

Des Moines

Thu 1/8

8:00 am-6:50 pm

2 stops9h 50m

$403

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 1/7

4:10 pm-9:50 pm

1 stop6h 40m

Des Moines

Sat 1/10

7:50 am-2:39 pm

1 stop5h 49m

$416

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 12/31

5:45 am-12:28 pm

1 stop7h 43m

Des Moines

Sun 1/11

6:24 am-12:08 pm

1 stop4h 44m

$417

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 1/7

11:12 am-9:50 pm

2 stops11h 38m

Des Moines

Sat 1/10

7:50 am-2:39 pm

1 stop5h 49m

$421

PortlandDes Moines

PWM - DSM

PWMDSM

Portland

Wed 1/7

11:12 am-9:50 pm

2 stops11h 38m

Des Moines

Sat 1/10

7:50 am-2:39 pm

1 stop5h 49m

$422

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Portland, Maine to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in August, then January is your next best option. Flight prices from Portland, Maine to Des Moines during January average around $318.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Portland, Maine to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $132. Flights from Portland, Maine to Des Moines on a Wednesday will generally be more expensive and average around $309. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Portland, Maine to Des Moines in the morning for as low as $163. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the afternoon because they tend to be around $466. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Portland, Maine to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Des Moines (PWM to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Des Moines

Fastest flight time

8h 39m

Direct flights

None
The fastest flight from Portland, Maine to Des Moines takes 8h 39m
There are no direct flights from Portland, Maine to Des Moines. There are no popular flight routes from Portland, Maine to Des Moines.
Search flight deals

  • How far is Portland to Des Moines by plane?

    Portland and Des Moines are 1192.1 mi apart from one another. Flights usually cover this in 8h 39m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Portland Airport to Des Moines Airport?

    Prices for flights from Portland Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Des Moines Airport?

  • How old do you have to be to fly from Portland Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland, Maine to Des Moines?

Best airlines flying from Portland, Maine to Des Moines

Compare and see reviews for airlines that fly from Portland, Maine to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $229Free CancellationRating
7.9
8,007 reviews
Search Delta flights
American AirlinesPriceFrom $249Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
United AirlinesPriceFrom $328Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Osceola
Boone
Norwalk
Grinnell
Oskaloosa
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Des Moines?

Finding the right flight to Des Moines from Portland is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Portland to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Portland to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Portland to Des Moines?

Once you have performed a search for Portland to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Portland to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Portland are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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