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Cheap flights from Portland, Maine to Des Moines from $201

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Des Moines departing on 10/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Portland, Maine to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:40 am - 2:16 pmPWM  Portland-DSM Des Moines
7h 36m1 stop Chicago O'Hare Intl
United Airlines Logo
3:20 pm - 9:23 pmDSM  Des Moines-PWM Portland
5h 03m1 stop Chicago O'Hare Intl
$339United Airlines
Sat, Aug 29 - Wed, Sep 2
American Airlines Logo
6:46 am - 1:25 pmPWM  Portland-DSM Des Moines
7h 39m1 stop Chicago O'Hare Intl
American Airlines Logo
6:55 am - 6:10 pmDSM  Des Moines-PWM Portland
10h 15m2 stops Chicago O'Hare Intl Philadelphia
$344American Airlines
Sat, Aug 29 - Wed, Sep 2
American Airlines Logo
6:02 am - 1:25 pmPWM  Portland-DSM Des Moines
8h 23m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
American Airlines Logo
6:55 am - 6:10 pmDSM  Des Moines-PWM Portland
10h 15m2 stops Chicago O'Hare Intl Philadelphia
$349American Airlines
Sat, Aug 29 - Wed, Sep 2
American Airlines Logo
5:38 pm - 12:04 amPWM  Portland-DSM Des Moines
7h 26m1 stop Chicago O'Hare Intl
American Airlines Logo
7:00 am - 3:51 pmDSM  Des Moines-PWM Portland
7h 51m1 stop New York LaGuardia
$362American Airlines
Fri, Sep 11 - Mon, Sep 14
Delta Logo
12:55 pm - 4:49 pmPWM  Portland-DSM Des Moines
4h 54m1 stop Detroit Metropolitan Wayne County
Delta Logo
2:34 pm - 11:17 pmDSM  Des Moines-PWM Portland
7h 43m2 stops Atlanta Hartsfield-Jackson New York LaGuardia
$390Delta
Fri, Sep 11 - Mon, Sep 14
United Airlines Logo
6:00 am - 10:31 amPWM  Portland-DSM Des Moines
5h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
3:11 pm - 9:46 pmDSM  Des Moines-PWM Portland
5h 35m1 stop Chicago O'Hare Intl
$476United Airlines
Thu, Oct 1 - Sun, Oct 4
United Airlines Logo
6:00 am - 10:31 amPWM  Portland-DSM Des Moines
5h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
3:11 pm - 9:46 pmDSM  Des Moines-PWM Portland
5h 35m1 stop Chicago O'Hare Intl
$477United Airlines
Thu, Oct 1 - Sun, Oct 4
United Airlines Logo
6:00 am - 10:31 amPWM  Portland-DSM Des Moines
5h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
1:24 pm - 11:59 pmDSM  Des Moines-PWM Portland
9h 35m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
$504United Airlines
Mon, Oct 5 - Fri, Oct 9
American Airlines Logo
4:27 pm - 9:41 pmPWM  Portland-DSM Des Moines
6h 14m1 stop New York LaGuardia
American Airlines Logo
9:26 am - 11:40 pmDSM  Des Moines-PWM Portland
13h 14m1 stop Chicago O'Hare Intl
$512American Airlines
Mon, Oct 5 - Fri, Oct 9
United Airlines Logo
6:00 am - 10:31 amPWM  Portland-DSM Des Moines
5h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
3:11 pm - 9:46 pmDSM  Des Moines-PWM Portland
5h 35m1 stop Chicago O'Hare Intl
$518United Airlines
Thu, Oct 1 - Sun, Oct 4

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United Airlines flights from Portland, Maine to Des Moines

Our best United Airlines deals on Portland, Maine to Des Moines flight tickets
United Airlines
Aug 29
PWM7:40 amPortland
7h 36m
1 stop
DSM2:16 pmDes Moines
Sep 2
DSM3:20 pmDes Moines
5h 03m
1 stop
PWM9:23 pmPortland
$339
United Airlines
Oct 1
PWM6:00 amPortland
5h 31m
1 stop
DSM10:31 amDes Moines
Oct 4
DSM3:11 pmDes Moines
5h 35m
1 stop
PWM9:46 pmPortland
$476
United Airlines
Oct 1
PWM6:00 amPortland
5h 31m
1 stop
DSM10:31 amDes Moines
Oct 4
DSM3:11 pmDes Moines
5h 35m
1 stop
PWM9:46 pmPortland
$477

American Airlines flights from Portland, Maine to Des Moines

Our best American Airlines deals on Portland, Maine to Des Moines flight tickets
American Airlines
Aug 29
PWM6:46 amPortland
7h 39m
1 stop
DSM1:25 pmDes Moines
Sep 2
DSM6:55 amDes Moines
10h 15m
2 stops
PWM6:10 pmPortland
$344
American Airlines
Aug 29
PWM6:02 amPortland
8h 23m
2 stops
DSM1:25 pmDes Moines
Sep 2
DSM6:55 amDes Moines
10h 15m
2 stops
PWM6:10 pmPortland
$349
American Airlines
Sep 11
PWM5:38 pmPortland
7h 26m
1 stop
DSM12:04 amDes Moines
Sep 14
DSM7:00 amDes Moines
7h 51m
1 stop
PWM3:51 pmPortland
$362

momondo Fare Finder

 
Customize your flight search to find flights from Portland, Maine to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Portland, Maine to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Sat 8/29

7:40 am-2:16 pm

1 stop7h 36m

Des Moines

Wed 9/2

3:20 pm-9:23 pm

1 stop5h 03m

$339

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Sat 8/29

6:46 am-1:25 pm

1 stop7h 39m

Des Moines

Wed 9/2

6:55 am-6:10 pm

2 stops10h 15m

$344

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Sat 8/29

6:02 am-1:25 pm

2 stops8h 23m

Des Moines

Wed 9/2

6:55 am-6:10 pm

2 stops10h 15m

$349

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Fri 9/11

5:38 pm-12:04 am

1 stop7h 26m

Des Moines

Mon 9/14

7:00 am-3:51 pm

1 stop7h 51m

$362

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Fri 9/11

12:55 pm-4:49 pm

1 stop4h 54m

Des Moines

Mon 9/14

2:34 pm-11:17 pm

2 stops7h 43m

$390
Quickest round-trip

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Thu 10/1

6:00 am-10:31 am

1 stop5h 31m

Des Moines

Sun 10/4

3:11 pm-9:46 pm

1 stop5h 35m

$476

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Thu 10/1

6:00 am-10:31 am

1 stop5h 31m

Des Moines

Sun 10/4

3:11 pm-9:46 pm

1 stop5h 35m

$477

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Mon 10/5

6:00 am-10:31 am

1 stop5h 31m

Des Moines

Fri 10/9

1:24 pm-11:59 pm

2 stops9h 35m

$504

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Mon 10/5

4:27 pm-9:41 pm

1 stop6h 14m

Des Moines

Fri 10/9

9:26 am-11:40 pm

1 stop13h 14m

$512

PortlandDes Moines

PWM Portland - DSM Des Moines

PWMDSM

Portland

Thu 10/1

6:00 am-10:31 am

1 stop5h 31m

Des Moines

Sun 10/4

3:11 pm-9:46 pm

1 stop5h 35m

$518

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Portland, Maine to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Portland, Maine and Des Moines?

Prices are currently typical for flights on this route.

Typical prices usually range from $296 to $446.
The lowest price recently found on this route was $339.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in April, then February is your next best option. Flight prices from Portland, Maine to Des Moines during February average around $0.

When to book flights from Portland, Maine to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Des Moines (PWM to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Des Moines

Fastest flight time

4h 54m

Direct flights

None
The fastest flight from Portland, Maine to Des Moines takes 4h 54m
There are no direct flights from Portland, Maine to Des Moines. There are no popular flight routes from Portland, Maine to Des Moines.
Search flight deals

Frequently asked questions about flying from Portland, Maine to Des Moines

  • How far is Portland to Des Moines by plane?

    Portland and Des Moines are 1192.1 mi apart from one another. Flights usually cover this in 4h 54m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Portland Airport to Des Moines Airport?

    Prices for flights from Portland Airport to Des Moines Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Des Moines Airport?

  • How old do you have to be to fly from Portland Airport to Des Moines Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland, Maine to Des Moines?

Best airlines flying from Portland, Maine to Des Moines

Compare and see reviews for airlines that fly from Portland, Maine to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $309Free CancellationRating
7.1
11,944 reviews
Search American Airlines flights
DeltaPriceFrom $311Free CancellationRating
7.8
8,503 reviews
Search Delta flights
United AirlinesPriceFrom $353Free CancellationRating
7.4
10,106 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Des Moines?

Finding the right flight to Des Moines from Portland is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Des Moines quick and easy, saving you time and money.

Can I find flights from Portland to Des Moines with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Portland to Des Moines flights to just show those with flexible booking policies.

How can momondo help me find flights from Portland to Des Moines?

Once you have performed a search for Portland to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Portland to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Portland are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Des Moines trip

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