Cheap flights from Phoenix to Des Moines from $80

If you’re not able to fly to Des Moines in November, then May is your next best option. Flight prices from Phoenix to Des Moines during May average around $339.

The cheapest day to depart from Phoenix to Des Moines is on a Tuesday. Travelers who choose to depart for Des Moines on a Tuesday will often find tickets for as low as $337. Flights from Phoenix to Des Moines on a Sunday will generally be more expensive and average around $497. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Phoenix to Des Moines in the afternoon for as low as $249. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $394. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Phoenix Sky Harbor Intl to Des Moines for the best Phoenix - Des Moines flight prices

You are more likely to see cheaper flights to Des Moines from Phoenix when booking weeks ahead of your departure date. In general, you can expect to find flights to Des Moines for around $369 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Des Moines from Phoenix for as low as $276 on momondo.

There are 3 cabin classes available to choose from on Phoenix to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Allegiant Air, Southwest, and Delta are the most popular carriers operating from Phoenix to Des Moines

American Airlines, Southwest and Frontier are the top three most popular airlines that fly to Des Moines from Phoenix according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 6 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

As of April 2026, there are 6 flights per day flying from Phoenix to Des Moines. The most common time of day flights depart is 8:00AM, with 38% of flights taking off in the afternoon.

As of April 2026, 45 flights take off from Phoenix and land in Des Moines each week. The most common flight departure day for this route is Mon, with 18% of weekly flights taking off on this day.