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Cheap flights from Panama City to St. Louis from $300

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 8/3. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Panama City to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
3:35 pm - 11:15 pm
PTY
-
STL
7h 40m
1 stop
American Airlines Logo
6:28 pm - 2:00 pm
STL
-
PTY
19h 32m
2 stops
$680American Airlines
Fri, Oct 16 - Mon, Oct 26
American Airlines Logo
3:35 pm - 11:15 pm
PTY
-
STL
7h 40m
1 stop
American Airlines Logo
6:08 pm - 2:00 pm
STL
-
PTY
19h 52m
1 stop
$690American Airlines
Fri, Oct 16 - Mon, Oct 26
United Airlines Logo
7:55 am - 10:45 pm
PTY
-
STL
14h 50m
1 stop
United Airlines Logo
6:15 am - 2:14 pm
STL
-
PTY
7h 59m
1 stop
$697United Airlines
Thu, Aug 6 - Mon, Aug 17
United Airlines Logo
3:30 pm - 3:38 pm
PTY
-
STL
24h 08m
2 stops
United Airlines Logo
8:00 am - 7:31 pm
STL
-
PTY
11h 31m
2 stops
$699United Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
10:55 pm - 12:11 pm
PTY
-
STL
13h 16m
2 stops
United Airlines Logo
8:50 am - 4:04 am
STL
-
PTY
19h 14m
2 stops
$701United Airlines
Thu, Aug 6 - Mon, Aug 17
United Airlines Logo
7:55 am - 5:42 pm
PTY
-
STL
9h 47m
1 stop
United Airlines Logo
6:15 am - 2:14 pm
STL
-
PTY
7h 59m
1 stop
$708United Airlines
Thu, Aug 6 - Tue, Aug 18
United Airlines Logo
10:55 pm - 12:02 pm
PTY
-
STL
13h 07m
2 stops
United Airlines Logo
8:00 am - 7:31 pm
STL
-
PTY
11h 31m
2 stops
$709United Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
10:55 pm - 12:11 pm
PTY
-
STL
13h 16m
2 stops
United Airlines Logo
8:00 am - 4:04 am
STL
-
PTY
20h 04m
2 stops
$712United Airlines
Thu, Aug 6 - Tue, Aug 18
United Airlines Logo
7:55 am - 10:20 pm
PTY
-
STL
14h 25m
1 stop
United Airlines Logo
6:15 am - 2:45 pm
STL
-
PTY
7h 30m
1 stop
$718United Airlines
Thu, Oct 29 - Sun, Nov 1
United Airlines Logo
10:55 pm - 3:46 pm
PTY
-
STL
16h 51m
2 stops
United Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
$720United Airlines
Mon, Jul 20 - Thu, Jul 23

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United Airlines flights from Panama City to St. Louis

Our best United Airlines deals on Panama City to St. Louis flight tickets
United Airlines
Aug 6
PTY7:55 amPanama City Tocumen Intl
14h 50m
1 stop
STL10:45 pmLambert-St Louis
Aug 17
STL6:15 amLambert-St Louis
7h 59m
1 stop
PTY2:14 pmPanama City Tocumen Intl
$697
United Airlines
Sep 6
PTY3:30 pmPanama City Tocumen Intl
24h 08m
2 stops
STL3:38 pmLambert-St Louis
Sep 10
STL8:00 amLambert-St Louis
11h 31m
2 stops
PTY7:31 pmPanama City Tocumen Intl
$699
United Airlines
Aug 6
PTY10:55 pmPanama City Tocumen Intl
13h 16m
2 stops
STL12:11 pmLambert-St Louis
Aug 17
STL8:50 amLambert-St Louis
19h 14m
2 stops
PTY4:04 amPanama City Tocumen Intl
$701

American Airlines flights from Panama City to St. Louis

Our best American Airlines deals on Panama City to St. Louis flight tickets
American Airlines
Oct 16
PTY3:35 pmPanama City Tocumen Intl
7h 40m
1 stop
STL11:15 pmLambert-St Louis
Oct 26
STL6:28 pmLambert-St Louis
19h 32m
2 stops
PTY2:00 pmPanama City Tocumen Intl
$680
American Airlines
Oct 16
PTY3:35 pmPanama City Tocumen Intl
7h 40m
1 stop
STL11:15 pmLambert-St Louis
Oct 26
STL6:08 pmLambert-St Louis
19h 52m
1 stop
PTY2:00 pmPanama City Tocumen Intl
$690
American Airlines
Jul 23
PTY1:14 pmPanama City Tocumen Intl
21h 10m
1 stop
STL10:24 amLambert-St Louis
Jul 30
STL5:48 pmLambert-St Louis
18h 26m
2 stops
PTY12:14 pmPanama City Tocumen Intl
$738

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 24, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 10/16

3:35 pm-11:15 pm

1 stop7h 40m

Lambert-St Louis

Mon 10/26

6:28 pm-2:00 pm

2 stops19h 32m

$680

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Fri 10/16

3:35 pm-11:15 pm

1 stop7h 40m

Lambert-St Louis

Mon 10/26

6:08 pm-2:00 pm

1 stop19h 52m

$690

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 8/6

7:55 am-10:45 pm

1 stop14h 50m

Lambert-St Louis

Mon 8/17

6:15 am-2:14 pm

1 stop7h 59m

$697

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 9/6

3:30 pm-3:38 pm

2 stops24h 08m

Lambert-St Louis

Thu 9/10

8:00 am-7:31 pm

2 stops11h 31m

$699

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 8/6

10:55 pm-12:11 pm

2 stops13h 16m

Lambert-St Louis

Mon 8/17

8:50 am-4:04 am

2 stops19h 14m

$701
Quickest round-trip

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 8/6

7:55 am-5:42 pm

1 stop9h 47m

Lambert-St Louis

Tue 8/18

6:15 am-2:14 pm

1 stop7h 59m

$708

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 9/6

10:55 pm-12:02 pm

2 stops13h 07m

Lambert-St Louis

Thu 9/10

8:00 am-7:31 pm

2 stops11h 31m

$709

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 8/6

10:55 pm-12:11 pm

2 stops13h 16m

Lambert-St Louis

Tue 8/18

8:00 am-4:04 am

2 stops20h 04m

$712

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 10/29

7:55 am-10:20 pm

1 stop14h 25m

Lambert-St Louis

Sun 11/1

6:15 am-2:45 pm

1 stop7h 30m

$718

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 7/20

10:55 pm-3:46 pm

2 stops16h 51m

Lambert-St Louis

Thu 7/23

6:01 am-4:04 am

1 stop22h 03m

$720

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, March is the cheapest month to fly from Panama City to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $360. The month of August is another great option to travel to St. Louis, with average flight prices from Panama City averaging around $484.

Can stopping save me money on Panama City to St. Louis flights?

You could potentially save up to 10% on your flight if you consider stops on a Panama City to St. Louis flight.

When to book flights from Panama City to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to St. Louis (PTY to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to St. Louis

Fastest flight time

14h 50m

Direct flights

None
The fastest flight from Panama City to St. Louis takes 14h 50m
There are no direct flights from Panama City to St. Louis. There are no popular flight routes from Panama City to St. Louis.
Search flight deals

Frequently asked questions about flying from Panama City to St. Louis

  • How far is Panama City Tocumen Intl to Lambert-St Louis by plane?

    The straight-line distance from Panama City Tocumen Intl to Lambert-St Louis is 2151.1 mi. Typically, this will take 14h 50m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City to St. Louis?

Best airlines flying from Panama City to St. Louis

Compare and see reviews for airlines that fly from Panama City to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $229Free CancellationRating
7.4
9,881 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
Maryland Heights
Florissant
O'Fallon
Collinsville
St. Peters
Alton
Wentzville
Farmington
Fenton
Clayton
Festus
Eureka
Litchfield
Edwardsville
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

Finding the right flight to St. Louis from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to St. Louis quick and easy, saving you time and money.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

Flights from Panama City to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Panama City.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

If you are simply researching potential flights to St. Louis, momondo offers a useful price alert feature which will track prices for flights to St. Louis from Panama City and alert you when they change.

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