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Cheap flights from Panama City to St. Louis from $366

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 5/7. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Panama City to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
Delta Logo
6:00 am - 12:50 pm
STL
-
PTY
6h 50m
1 stop
$624Delta
Thu, May 7 - Tue, May 12
United Airlines Logo
10:00 am - 10:30 pm
PTY
-
STL
12h 30m
1 stop
United Airlines Logo
7:45 am - 6:37 pm
STL
-
PTY
10h 52m
2 stops
$634United Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$643American Airlines
Tue, May 5 - Tue, May 12
American Airlines Logo
1:49 pm - 8:54 am
PTY
-
STL
19h 05m
2 stops
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$648American Airlines
Tue, May 5 - Tue, May 12
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
Delta Logo
6:00 am - 12:50 pm
STL
-
PTY
6h 50m
1 stop
$650Delta
Sat, May 16 - Tue, May 19
United Airlines Logo
7:55 am - 10:45 pm
PTY
-
STL
14h 50m
2 stops
United Airlines Logo
6:00 am - 4:12 pm
STL
-
PTY
10h 12m
1 stop
$656United Airlines
Thu, May 7 - Thu, May 14
American Airlines Logo
1:49 pm - 11:27 am
PTY
-
STL
21h 38m
2 stops
American Airlines Logo
3:42 pm - 12:46 pm
STL
-
PTY
21h 04m
2 stops
$659American Airlines
Sat, May 16 - Tue, May 19
United Airlines Logo
7:55 am - 9:13 pm
PTY
-
STL
13h 18m
2 stops
United Airlines Logo
8:30 pm - 2:14 pm
STL
-
PTY
17h 44m
2 stops
$677United Airlines
Thu, May 7 - Thu, May 14
Multiple Airlines Logo
5:30 am - 5:49 pm
PTY
-
STL
12h 19m
2 stops
Multiple Airlines Logo
11:10 am - 1:55 am
STL
-
PTY
14h 45m
2 stops
$693Multiple Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
10:00 am - 9:30 am
PTY
-
STL
23h 30m
1 stop
United Airlines Logo
4:48 pm - 4:04 am
STL
-
PTY
11h 16m
1 stop
$699United Airlines
Mon, May 18 - Fri, Jul 31

Delta flights from Panama City to St. Louis

Our best Delta deals on Panama City to St. Louis flight tickets
Delta
May 7
PTY2:15 pmPanama City Tocumen Intl
9h 44m
1 stop
STL11:59 pmLambert-St Louis
May 12
STL6:00 amLambert-St Louis
6h 50m
1 stop
PTY12:50 pmPanama City Tocumen Intl
$624
Delta
May 16
PTY2:15 pmPanama City Tocumen Intl
9h 44m
1 stop
STL11:59 pmLambert-St Louis
May 19
STL6:00 amLambert-St Louis
6h 50m
1 stop
PTY12:50 pmPanama City Tocumen Intl
$650
Delta
Sep 6
PTY2:28 pmPanama City Tocumen Intl
9h 09m
1 stop
STL11:37 pmLambert-St Louis
Sep 10
STL6:00 amLambert-St Louis
6h 56m
1 stop
PTY12:56 pmPanama City Tocumen Intl
$721

United Airlines flights from Panama City to St. Louis

Our best United Airlines deals on Panama City to St. Louis flight tickets
United Airlines
May 7
PTY10:00 amPanama City Tocumen Intl
12h 30m
1 stop
STL10:30 pmLambert-St Louis
May 12
STL7:45 amLambert-St Louis
10h 52m
2 stops
PTY6:37 pmPanama City Tocumen Intl
$634
United Airlines
May 7
PTY7:55 amPanama City Tocumen Intl
14h 50m
2 stops
STL10:45 pmLambert-St Louis
May 14
STL6:00 amLambert-St Louis
10h 12m
1 stop
PTY4:12 pmPanama City Tocumen Intl
$656
United Airlines
May 7
PTY7:55 amPanama City Tocumen Intl
13h 18m
2 stops
STL9:13 pmLambert-St Louis
May 14
STL8:30 pmLambert-St Louis
17h 44m
2 stops
PTY2:14 pmPanama City Tocumen Intl
$677

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/7

2:15 pm-11:59 pm

1 stop9h 44m

Lambert-St Louis

Tue 5/12

6:00 am-12:50 pm

1 stop6h 50m

$624

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/7

10:00 am-10:30 pm

1 stop12h 30m

Lambert-St Louis

Tue 5/12

7:45 am-6:37 pm

2 stops10h 52m

$634
Quickest round-trip

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 5/5

1:49 pm-10:24 pm

1 stop8h 35m

Lambert-St Louis

Tue 5/12

5:24 am-12:46 pm

1 stop7h 22m

$643

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 5/5

1:49 pm-8:54 am

2 stops19h 05m

Lambert-St Louis

Tue 5/12

5:24 am-12:46 pm

1 stop7h 22m

$648

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/16

2:15 pm-11:59 pm

1 stop9h 44m

Lambert-St Louis

Tue 5/19

6:00 am-12:50 pm

1 stop6h 50m

$650

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/7

7:55 am-10:45 pm

2 stops14h 50m

Lambert-St Louis

Thu 5/14

6:00 am-4:12 pm

1 stop10h 12m

$656

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/16

1:49 pm-11:27 am

2 stops21h 38m

Lambert-St Louis

Tue 5/19

3:42 pm-12:46 pm

2 stops21h 04m

$659

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Thu 5/7

7:55 am-9:13 pm

2 stops13h 18m

Lambert-St Louis

Thu 5/14

8:30 pm-2:14 pm

2 stops17h 44m

$677

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sun 9/6

5:30 am-5:49 pm

2 stops12h 19m

Lambert-St Louis

Thu 9/10

11:10 am-1:55 am

2 stops14h 45m

$693

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 5/18

10:00 am-9:30 am

1 stop23h 30m

Lambert-St Louis

Fri 7/31

4:48 pm-4:04 am

1 stop11h 16m

$699

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, March is the cheapest month to fly from Panama City to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $360. The month of June is another great option to travel to St. Louis, with average flight prices from Panama City averaging around $362.

Can stopping save me money on Panama City to St. Louis flights?

You could potentially save up to 9% on your flight if you consider stops on a Panama City to St. Louis flight.

When to book flights from Panama City to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to St. Louis (PTY to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to St. Louis

Fastest flight time

9h 09m

Direct flights

None
The fastest flight from Panama City to St. Louis takes 9h 09m
There are no direct flights from Panama City to St. Louis. There are no popular flight routes from Panama City to St. Louis.
Search flight deals

  • How far is Panama City Tocumen Intl to Lambert-St Louis by plane?

    The straight-line distance from Panama City Tocumen Intl to Lambert-St Louis is 2151.1 mi. Typically, this will take 9h 09m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City to St. Louis?

Best airlines flying from Panama City to St. Louis

Compare and see reviews for airlines that fly from Panama City to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $387Free CancellationRating
7.4
9,460 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Collinsville
St. Peters
Wentzville
Alton
Fenton
Farmington
Clayton
Festus
Edwardsville
Eureka
Litchfield
Shrewsbury
Grafton

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

Finding the right flight to St. Louis from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to St. Louis quick and easy, saving you time and money.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

Flights from Panama City to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Panama City.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

If you are simply researching potential flights to St. Louis, momondo offers a useful price alert feature which will track prices for flights to St. Louis from Panama City and alert you when they change.

An easier way to manage your St. Louis trip

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