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Cheap flights from Panama City to St. Louis from $409

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 12/17. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Panama City to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
JetBlue Logo
2:24 pm - 10:17 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
19h 53m1 stop Atlanta Hartsfield-Jackson
JetBlue Logo
6:00 am - 1:59 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 59m1 stop Atlanta Hartsfield-Jackson
$614JetBlue
Sat, Oct 31 - Sat, Nov 7
JetBlue Logo
2:20 pm - 11:31 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 11m1 stop Atlanta Hartsfield-Jackson
JetBlue Logo
6:00 am - 12:58 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 58m1 stop Atlanta Hartsfield-Jackson
$627JetBlue
Sun, Sep 6 - Thu, Sep 10
JetBlue Logo
2:24 pm - 10:17 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
19h 53m1 stop Atlanta Hartsfield-Jackson
JetBlue Logo
6:00 am - 1:59 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 59m1 stop Atlanta Hartsfield-Jackson
$673JetBlue
Sat, Oct 31 - Sat, Nov 7
JetBlue Logo
2:20 pm - 11:31 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 11m1 stop Atlanta Hartsfield-Jackson
JetBlue Logo
6:00 am - 12:58 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 58m1 stop Atlanta Hartsfield-Jackson
$689JetBlue
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
3:30 pm - 12:13 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
20h 43m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:00 am - 7:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
13h 02m1 stop Newark
$718United Airlines
Thu, Oct 22 - Mon, Oct 26
United Airlines Logo
10:00 am - 10:30 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
12h 30m1 stop Houston George Bush Intcntl
United Airlines Logo
6:15 am - 1:45 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 30m1 stop Houston George Bush Intcntl
$718United Airlines
Thu, Oct 22 - Mon, Oct 26
United Airlines Logo
3:30 pm - 3:43 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
24h 13m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:00 am - 7:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
13h 02m2 stops Chicago O'Hare Intl Newark
$723United Airlines
Thu, Oct 22 - Mon, Oct 26
American Airlines Logo
1:16 pm - 11:59 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
10h 43m1 stop Miami
American Airlines Logo
5:00 am - 12:16 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 16m1 stop Miami
$740American Airlines
Fri, Sep 25 - Fri, Oct 2
United Airlines Logo
3:30 pm - 12:13 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
20h 43m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:00 am - 7:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
13h 02m1 stop Newark
$740United Airlines
Thu, Oct 22 - Mon, Oct 26
United Airlines Logo
10:00 am - 10:30 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
12h 30m1 stop Houston George Bush Intcntl
United Airlines Logo
6:15 am - 1:45 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 30m1 stop Houston George Bush Intcntl
$740United Airlines
Thu, Oct 22 - Mon, Oct 26

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United Airlines flights from Panama City to St. Louis

Our best United Airlines deals on Panama City to St. Louis flight tickets
United Airlines
Oct 22
PTY10:00 amPanama City Tocumen Intl
12h 30m
1 stop
STL10:30 pmLambert-St Louis
Oct 26
STL6:15 amLambert-St Louis
7h 30m
1 stop
PTY1:45 pmPanama City Tocumen Intl
$718
United Airlines
Oct 22
PTY3:30 pmPanama City Tocumen Intl
24h 13m
2 stops
STL3:43 pmLambert-St Louis
Oct 26
STL6:00 amLambert-St Louis
13h 02m
2 stops
PTY7:02 pmPanama City Tocumen Intl
$723
United Airlines
Oct 22
PTY10:00 amPanama City Tocumen Intl
12h 30m
1 stop
STL10:30 pmLambert-St Louis
Oct 26
STL6:15 amLambert-St Louis
7h 30m
1 stop
PTY1:45 pmPanama City Tocumen Intl
$740

American Airlines flights from Panama City to St. Louis

Our best American Airlines deals on Panama City to St. Louis flight tickets
American Airlines
Sep 25
PTY1:16 pmPanama City Tocumen Intl
20h 08m
2 stops
STL9:24 amLambert-St Louis
Oct 2
STL5:00 amLambert-St Louis
7h 16m
1 stop
PTY12:16 pmPanama City Tocumen Intl
$744
American Airlines
Sep 25
PTY1:16 pmPanama City Tocumen Intl
21h 13m
2 stops
STL10:29 amLambert-St Louis
Oct 2
STL5:13 pmLambert-St Louis
19h 03m
2 stops
PTY12:16 pmPanama City Tocumen Intl
$776

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 13, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Sat 10/31

2:24 pm-10:17 am

1 stop19h 53m

Lambert-St Louis

Sat 11/7

6:00 am-1:59 pm

1 stop6h 59m

$614
Quickest round-trip

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Sun 9/6

2:20 pm-11:31 pm

1 stop9h 11m

Lambert-St Louis

Thu 9/10

6:00 am-12:58 pm

1 stop6h 58m

$627

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Sat 10/31

2:24 pm-10:17 am

1 stop19h 53m

Lambert-St Louis

Sat 11/7

6:00 am-1:59 pm

1 stop6h 59m

$673

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Sun 9/6

2:20 pm-11:31 pm

1 stop9h 11m

Lambert-St Louis

Thu 9/10

6:00 am-12:58 pm

1 stop6h 58m

$689

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Thu 10/22

3:30 pm-12:13 pm

2 stops20h 43m

Lambert-St Louis

Mon 10/26

6:00 am-7:02 pm

1 stop13h 02m

$718

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Thu 10/22

10:00 am-10:30 pm

1 stop12h 30m

Lambert-St Louis

Mon 10/26

6:15 am-1:45 pm

1 stop7h 30m

$718

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Thu 10/22

3:30 pm-3:43 pm

2 stops24h 13m

Lambert-St Louis

Mon 10/26

6:00 am-7:02 pm

2 stops13h 02m

$723

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Fri 9/25

1:16 pm-11:59 pm

1 stop10h 43m

Lambert-St Louis

Fri 10/2

5:00 am-12:16 pm

1 stop7h 16m

$740

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Thu 10/22

3:30 pm-12:13 pm

2 stops20h 43m

Lambert-St Louis

Mon 10/26

6:00 am-7:02 pm

1 stop13h 02m

$740

Panama CitySt. Louis

PTY Panama City Tocumen Intl - STL Lambert-St Louis

PTYSTL

Panama City Tocumen Intl

Thu 10/22

10:00 am-10:30 pm

1 stop12h 30m

Lambert-St Louis

Mon 10/26

6:15 am-1:45 pm

1 stop7h 30m

$740

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Panama City and St. Louis?

Prices are currently typical for flights on this route.

Typical prices usually range from $387 to $671.
The lowest price recently found on this route was $614.

What is the cheapest month to fly to St. Louis?

In general, March is the cheapest month to fly from Panama City to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $360. The month of April is another great option to travel to St. Louis, with average flight prices from Panama City averaging around $546.

When to book flights from Panama City to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to St. Louis (PTY to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to St. Louis

Fastest flight time

9h 11m

Direct flights

None
The fastest flight from Panama City to St. Louis takes 9h 11m
There are no direct flights from Panama City to St. Louis. There are no popular flight routes from Panama City to St. Louis.
Search flight deals

Frequently asked questions about flying from Panama City to St. Louis

  • How far is Panama City Tocumen Intl to Lambert-St Louis by plane?

    The straight-line distance from Panama City Tocumen Intl to Lambert-St Louis is 2151.1 mi. Typically, this will take 9h 11m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City to St. Louis?

Best airlines flying from Panama City to St. Louis

Compare and see reviews for airlines that fly from Panama City to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $229Free CancellationRating
7.4
10,111 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
St. Peters
Maryland Heights
Collinsville
Florissant
Alton
O'Fallon
Farmington
Clayton
Fenton
Festus
Wentzville
Eureka
Edwardsville
Litchfield
Grafton
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

Finding the right flight to St. Louis from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to St. Louis quick and easy, saving you time and money.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

Flights from Panama City to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Panama City.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

If you are simply researching potential flights to St. Louis, momondo offers a useful price alert feature which will track prices for flights to St. Louis from Panama City and alert you when they change.

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