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Cheap flights from Panama City to St. Louis from $343

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 4/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Panama City to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
10:55 pm - 3:46 pm
PTY
-
STL
16h 51m
2 stops
United Airlines Logo
6:20 am - 6:37 pm
STL
-
PTY
12h 17m
1 stop
$573United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m
1 stop
United Airlines Logo
7:41 am - 2:45 pm
STL
-
PTY
30h 04m
2 stops
$659United Airlines
Tue, Feb 24 - Sat, Feb 28
Copa Airlines Logo
10:55 pm - 11:57 pm
PTY
-
STL
25h 02m
1 stop
Copa Airlines Logo
6:00 am - 2:14 pm
STL
-
PTY
8h 14m
1 stop
$665Copa Airlines
Mon, Mar 30 - Sat, Apr 11
Multiple Airlines Logo
10:55 pm - 11:57 pm
PTY
-
STL
25h 02m
1 stop
Multiple Airlines Logo
7:45 am - 7:31 pm
STL
-
PTY
11h 46m
2 stops
$669Multiple Airlines
Mon, Mar 30 - Sat, Apr 11
United Airlines Logo
4:41 pm - 3:38 pm
PTY
-
STL
23h 57m
1 stop
United Airlines Logo
10:10 am - 2:45 pm
STL
-
PTY
27h 35m
1 stop
$675United Airlines
Tue, Feb 24 - Sat, Feb 28
American Airlines Logo
1:40 pm - 10:59 am
PTY
-
STL
21h 19m
2 stops
American Airlines Logo
6:53 pm - 12:46 pm
STL
-
PTY
17h 53m
2 stops
$694American Airlines
Mon, Mar 30 - Sat, Apr 11
United Airlines Logo
7:55 am - 8:38 pm
PTY
-
STL
12h 43m
1 stop
United Airlines Logo
6:20 am - 6:37 pm
STL
-
PTY
12h 17m
1 stop
$780United Airlines
Sat, May 30 - Tue, Jun 2
Multiple Airlines Logo
11:25 am - 11:58 pm
PTY
-
STL
36h 33m
3 stops
Multiple Airlines Logo
4:05 pm - 2:15 pm
STL
-
PTY
22h 10m
2 stops
$7,697Multiple Airlines
Mon, Mar 30 - Sat, Apr 11
Multiple Airlines Logo
11:25 am - 11:58 pm
PTY
-
STL
36h 33m
3 stops
Multiple Airlines Logo
6:21 am - 2:55 pm
STL
-
PTY
32h 34m
3 stops
$13,986Multiple Airlines
Mon, Mar 30 - Sat, Apr 11

United Airlines flights from Panama City to St. Louis

Our best United Airlines deals on Panama City to St. Louis flight tickets
United Airlines
May 30
PTY10:55 pmPanama City Tocumen Intl
16h 51m
2 stops
STL3:46 pmLambert-St Louis
Jun 2
STL6:20 amLambert-St Louis
12h 17m
1 stop
PTY6:37 pmPanama City Tocumen Intl
$573
United Airlines
Feb 24
PTY4:41 pmPanama City Tocumen Intl
17h 42m
1 stop
STL9:23 amLambert-St Louis
Feb 28
STL7:41 amLambert-St Louis
30h 04m
2 stops
PTY2:45 pmPanama City Tocumen Intl
$659
United Airlines
Feb 24
PTY4:41 pmPanama City Tocumen Intl
23h 57m
1 stop
STL3:38 pmLambert-St Louis
Feb 28
STL10:10 amLambert-St Louis
27h 35m
1 stop
PTY2:45 pmPanama City Tocumen Intl
$675

American Airlines flights from Panama City to St. Louis

Our best American Airlines deals on Panama City to St. Louis flight tickets
American Airlines
Mar 30
PTY1:40 pmPanama City Tocumen Intl
21h 19m
2 stops
STL10:59 amLambert-St Louis
Apr 11
STL6:53 pmLambert-St Louis
17h 53m
2 stops
PTY12:46 pmPanama City Tocumen Intl
$694
American Airlines
Feb 11
PTY2:27 pmPanama City Tocumen Intl
19h 28m
2 stops
STL8:55 amLambert-St Louis
Feb 19
STL6:57 pmLambert-St Louis
19h 18m
2 stops
PTY3:15 pmPanama City Tocumen Intl
$754
American Airlines
Feb 11
PTY2:27 pmPanama City Tocumen Intl
21h 05m
1 stop
STL10:32 amLambert-St Louis
Feb 19
STL6:57 pmLambert-St Louis
19h 18m
2 stops
PTY3:15 pmPanama City Tocumen Intl
$800

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Panama City to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/30

10:55 pm-3:46 pm

2 stops16h 51m

Lambert-St Louis

Tue 6/2

6:20 am-6:37 pm

1 stop12h 17m

$573

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/24

4:41 pm-9:23 am

1 stop17h 42m

Lambert-St Louis

Sat 2/28

7:41 am-2:45 pm

2 stops30h 04m

$659

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 3/30

10:55 pm-11:57 pm

1 stop25h 02m

Lambert-St Louis

Sat 4/11

6:00 am-2:14 pm

1 stop8h 14m

$665

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 3/30

10:55 pm-11:57 pm

1 stop25h 02m

Lambert-St Louis

Sat 4/11

7:45 am-7:31 pm

2 stops11h 46m

$669

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Tue 2/24

4:41 pm-3:38 pm

1 stop23h 57m

Lambert-St Louis

Sat 2/28

10:10 am-2:45 pm

1 stop27h 35m

$675

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 3/30

1:40 pm-10:59 am

2 stops21h 19m

Lambert-St Louis

Sat 4/11

6:53 pm-12:46 pm

2 stops17h 53m

$694

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 5/30

7:55 am-8:38 pm

1 stop12h 43m

Lambert-St Louis

Tue 6/2

6:20 am-6:37 pm

1 stop12h 17m

$780

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 3/30

11:25 am-11:58 pm

3 stops36h 33m

Lambert-St Louis

Sat 4/11

4:05 pm-2:15 pm

2 stops22h 10m

$7,697

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Mon 3/30

11:25 am-11:58 pm

3 stops36h 33m

Lambert-St Louis

Sat 4/11

6:21 am-2:55 pm

3 stops32h 34m

$13,986

Panama CitySt. Louis

PTY - STL

PTYSTL

Panama City Tocumen Intl

Sat 4/18

5:30 am-10:28 pm

2 stops16h 58m

$343

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 12 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Panama City to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, June is the cheapest month to fly from Panama City to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $362. The month of March is another great option to travel to St. Louis, with average flight prices from Panama City averaging around $386.

When to book flights from Panama City to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to St. Louis (PTY to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to St. Louis

Fastest flight time

7h 57m

Direct flights

None
The fastest flight from Panama City to St. Louis takes 7h 57m
There are no direct flights from Panama City to St. Louis. There are no popular flight routes from Panama City to St. Louis.
Search flight deals

  • How far is Panama City Tocumen Intl to Lambert-St Louis by plane?

    The straight-line distance from Panama City Tocumen Intl to Lambert-St Louis is 2151.1 mi. Typically, this will take 7h 57m by plane in normal conditions.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport were last updated today.

  • How many operators does momondo search for flights from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The travel and health documents required for your trip to Lambert-St Louis Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Lambert-St Louis Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Panama City to St. Louis?

Best airlines flying from Panama City to St. Louis

Compare and see reviews for airlines that fly from Panama City to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $387Free CancellationRating
7.4
9,240 reviews
Search United Airlines flights

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Collinsville
St. Peters
Fenton
Wentzville
Alton
Farmington
Clayton
Edwardsville
Eureka
Festus
Litchfield
Glencoe
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to St. Louis?

Finding the right flight to St. Louis from Panama City is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to St. Louis quick and easy, saving you time and money.

Can I find flights from Panama City to St. Louis with flexible booking policies on momondo?

Flights from Panama City to St. Louis with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Panama City to St. Louis?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to St. Louis from Panama City.

I’m not ready to book a flight from Panama City to St. Louis right now. Can momondo alert me if prices change?

If you are simply researching potential flights to St. Louis, momondo offers a useful price alert feature which will track prices for flights to St. Louis from Panama City and alert you when they change.

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