Cheap flights from Panama City to Illinois from $325

The cheapest month to fly to Illinois from Panama City is in October. Flight prices, which tend to average around $556, are often lower during this time because this is during the off-season. If you aren’t able to travel to Illinois during the month of October, then flying in November is also cheap. Prices for this month can be found on momondo for an average of $566.

The cheapest day to depart from Panama City to Illinois is on a Saturday when prices can be found for as low as $533. Flights from Panama City to Illinois on a Monday will generally be more expensive and average around $917. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

Our most recent data shows that the best time of day to fly to Illinois is in the evening. Flights from Panama City to Illinois during this time can be as low as $781. Flights in the morning are often more expensive with an average ticket price of $823.

Fly from Panama City Tocumen Intl to Chicago O'Hare Intl for the best Panama City Tocumen Intl - Illinois flight prices

You are more likely to see cheaper flights to Illinois from Panama City when booking weeks ahead of your departure date. In general, you can expect to find flights to Illinois for around $689 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Illinois from Panama City for as low as $417 on momondo.

There are 3 cabin classes available to choose from on Panama City to Illinois flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

The number of flights available between Panama City and Illinois is 2 per day as of September 2026. The most frequent departure time is 7:00PM, with 53% of daily flights leaving in the evening.

As of September 2026, 20 flights take off from Panama City and land in Illinois each week. The most common flight departure day for this route is Wed, with 25% of weekly flights taking off on this day.