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Cheap flights from Panama City to Buffalo from $337

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Buffalo departing on 4/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:26 am - 11:09 am
PTY
-
BUF
23h 43m
1 stop
Multiple Airlines Logo
1:11 pm - 8:34 pm
BUF
-
PTY
8h 23m
1 stop
$611Multiple Airlines
Sat, Apr 25 - Sat, May 2
United Airlines Logo
3:30 pm - 10:05 am
PTY
-
BUF
17h 35m
2 stops
United Airlines Logo
10:45 am - 7:31 pm
BUF
-
PTY
9h 46m
1 stop
$632United Airlines
Sat, Apr 25 - Sat, May 2
United Airlines Logo
9:45 am - 10:10 am
PTY
-
BUF
23h 25m
2 stops
United Airlines Logo
10:30 am - 7:31 pm
BUF
-
PTY
10h 01m
1 stop
$646United Airlines
Thu, Apr 23 - Sun, Apr 26
American Airlines Logo
1:49 pm - 2:21 pm
PTY
-
BUF
23h 32m
2 stops
American Airlines Logo
5:32 pm - 12:46 pm
BUF
-
PTY
20h 14m
2 stops
$655American Airlines
Wed, Apr 29 - Wed, May 6
United Airlines Logo
10:00 am - 10:00 am
PTY
-
BUF
23h 00m
2 stops
United Airlines Logo
6:55 pm - 4:04 am
BUF
-
PTY
10h 09m
1 stop
$661United Airlines
Thu, Apr 9 - Mon, Apr 13
United Airlines Logo
3:30 pm - 10:10 am
PTY
-
BUF
17h 40m
2 stops
United Airlines Logo
7:00 am - 6:37 pm
BUF
-
PTY
12h 37m
2 stops
$667United Airlines
Thu, Apr 23 - Sun, Apr 26
United Airlines Logo
10:55 pm - 9:47 am
PTY
-
BUF
9h 52m
1 stop
United Airlines Logo
10:30 am - 7:31 pm
BUF
-
PTY
10h 01m
1 stop
$670United Airlines
Thu, Apr 23 - Sun, Apr 26
United Airlines Logo
10:55 pm - 9:47 am
PTY
-
BUF
9h 52m
1 stop
United Airlines Logo
7:00 am - 6:37 pm
BUF
-
PTY
12h 37m
2 stops
$675United Airlines
Thu, Apr 23 - Sun, Apr 26
United Airlines Logo
10:55 pm - 9:47 am
PTY
-
BUF
9h 52m
1 stop
United Airlines Logo
7:00 am - 6:37 pm
BUF
-
PTY
12h 37m
2 stops
$696United Airlines
Thu, Apr 23 - Sun, Apr 26
United Airlines Logo
10:55 pm - 9:47 am
PTY
-
BUF
9h 52m
1 stop
United Airlines Logo
6:55 pm - 4:04 am
BUF
-
PTY
10h 09m
1 stop
$720United Airlines
Thu, Apr 23 - Sun, Apr 26

United Airlines flights from Panama City to Buffalo

Our best United Airlines deals on Panama City to Buffalo flight tickets
United Airlines
Apr 25
PTY3:30 pmPanama City Tocumen Intl
17h 35m
2 stops
BUF10:05 amBuffalo
May 2
BUF10:45 amBuffalo
9h 46m
1 stop
PTY7:31 pmPanama City Tocumen Intl
$632
United Airlines
Apr 23
PTY9:45 amPanama City Tocumen Intl
23h 25m
2 stops
BUF10:10 amBuffalo
Apr 26
BUF10:30 amBuffalo
10h 01m
1 stop
PTY7:31 pmPanama City Tocumen Intl
$646
United Airlines
Apr 9
PTY10:00 amPanama City Tocumen Intl
23h 00m
2 stops
BUF10:00 amBuffalo
Apr 13
BUF6:55 pmBuffalo
10h 09m
1 stop
PTY4:04 amPanama City Tocumen Intl
$661

American Airlines flights from Panama City to Buffalo

Our best American Airlines deals on Panama City to Buffalo flight tickets
American Airlines
Apr 29
PTY1:49 pmPanama City Tocumen Intl
23h 32m
2 stops
BUF2:21 pmBuffalo
May 6
BUF5:32 pmBuffalo
20h 14m
2 stops
PTY12:46 pmPanama City Tocumen Intl
$655
American Airlines
Mar 24
PTY3:10 pmPanama City Tocumen Intl
18h 48m
2 stops
BUF10:58 amBuffalo
Mar 27
BUF4:04 pmBuffalo
23h 16m
2 stops
PTY2:20 pmPanama City Tocumen Intl
$911
American Airlines
Jun 13
PTY1:14 pmPanama City Tocumen Intl
19h 17m
2 stops
BUF9:31 amBuffalo
Jun 28
BUF4:46 pmBuffalo
20h 27m
2 stops
PTY12:13 pmPanama City Tocumen Intl
$927

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 14, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/25

10:26 am-11:09 am

1 stop23h 43m

Buffalo

Sat 5/2

1:11 pm-8:34 pm

1 stop8h 23m

$611

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 4/25

3:30 pm-10:05 am

2 stops17h 35m

Buffalo

Sat 5/2

10:45 am-7:31 pm

1 stop9h 46m

$632

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/23

9:45 am-10:10 am

2 stops23h 25m

Buffalo

Sun 4/26

10:30 am-7:31 pm

1 stop10h 01m

$646

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Wed 4/29

1:49 pm-2:21 pm

2 stops23h 32m

Buffalo

Wed 5/6

5:32 pm-12:46 pm

2 stops20h 14m

$655

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/9

10:00 am-10:00 am

2 stops23h 00m

Buffalo

Mon 4/13

6:55 pm-4:04 am

1 stop10h 09m

$661

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/23

3:30 pm-10:10 am

2 stops17h 40m

Buffalo

Sun 4/26

7:00 am-6:37 pm

2 stops12h 37m

$667
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/23

10:55 pm-9:47 am

1 stop9h 52m

Buffalo

Sun 4/26

10:30 am-7:31 pm

1 stop10h 01m

$670

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/23

10:55 pm-9:47 am

1 stop9h 52m

Buffalo

Sun 4/26

7:00 am-6:37 pm

2 stops12h 37m

$675

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/23

10:55 pm-9:47 am

1 stop9h 52m

Buffalo

Sun 4/26

7:00 am-6:37 pm

2 stops12h 37m

$696

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 4/23

10:55 pm-9:47 am

1 stop9h 52m

Buffalo

Sun 4/26

6:55 pm-4:04 am

1 stop10h 09m

$720

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Panama City to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Panama City to Buffalo flights?

You could potentially save up to 11% on your flight if you consider stops on a Panama City to Buffalo flight.

When to book flights from Panama City to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Buffalo (PTY to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Buffalo

Fastest flight time

8h 18m

Direct flights

None
The fastest flight from Panama City to Buffalo takes 8h 18m
There are no direct flights from Panama City to Buffalo. There are no popular flight routes from Panama City to Buffalo.
Search flight deals

  • How far is Panama City Tocumen Intl to Buffalo by plane?

    Buffalo is 2341.1 mi away from Panama City Tocumen Intl. Flights usually cover this in 8h 18m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Buffalo Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Buffalo Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Buffalo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The required travel and health documents for your Buffalo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Buffalo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to Buffalo for you.

Can I find flights from Panama City to Buffalo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Panama City to Buffalo flights to just show those with flexible booking policies.

How can momondo help me find flights from Panama City to Buffalo?

momondo helps you find the best flight between Panama City and Buffalo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Buffalo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Buffalo from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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