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Cheap flights from Panama City to Buffalo from $342

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Panama City to Buffalo departing on 8/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Panama City to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:50 pm - 3:01 pm-
22h 11m
Multiple Airlines Logo
8:00 pm - 6:55 pm-
23h 55m
$581Multiple Airlines
Sun, Oct 18 - Wed, Oct 28
Multiple Airlines Logo
3:50 pm - 8:24 am-
15h 34m
Multiple Airlines Logo
8:00 pm - 2:55 pm-
19h 55m
$588Multiple Airlines
Sun, Oct 18 - Wed, Oct 28
Multiple Airlines Logo
11:25 am - 3:01 pm-
26h 36m
Multiple Airlines Logo
3:30 pm - 2:55 pm-
24h 25m
$594Multiple Airlines
Sun, Oct 18 - Wed, Oct 28
Multiple Airlines Logo
5:30 am - 7:52 am-
25h 22m
Multiple Airlines Logo
8:02 pm - 1:55 am-
30h 53m
$653Multiple Airlines
Sat, Aug 22 - Sun, Aug 30
Multiple Airlines Logo
3:50 pm - 7:22 am-
14h 32m
Multiple Airlines Logo
8:02 pm - 1:55 am-
30h 53m
$657Multiple Airlines
Fri, Aug 21 - Sun, Aug 30
Multiple Airlines Logo
5:30 am - 2:43 pm-
32h 13m
Multiple Airlines Logo
3:33 pm - 10:30 am-
19h 57m
$660Multiple Airlines
Thu, Sep 10 - Fri, Sep 25
Multiple Airlines Logo
11:25 am - 7:22 am-
18h 57m
Multiple Airlines Logo
8:02 pm - 1:55 am-
30h 53m
$667Multiple Airlines
Fri, Aug 21 - Sun, Aug 30
Multiple Airlines Logo
3:50 pm - 2:59 pm-
22h 09m
Multiple Airlines Logo
8:07 pm - 10:30 am-
15h 23m
$691Multiple Airlines
Mon, Aug 17 - Mon, Aug 24
Multiple Airlines Logo
5:30 am - 2:43 pm-
32h 13m
Multiple Airlines Logo
7:50 pm - 2:55 pm-
20h 05m
$706Multiple Airlines
Thu, Sep 10 - Fri, Sep 25
United Airlines Logo
7:55 am - 9:42 am-
24h 47m
United Airlines Logo
6:30 am - 8:02 pm-
13h 32m
$736United Airlines
Mon, Oct 26 - Mon, Nov 9

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Avianca flights from Panama City to Buffalo

Our best Avianca deals on Panama City to Buffalo flight tickets
Avianca
Sep 12
PTY5:30 amPanama City Tocumen Intl
12h 34m
2 stops
BUF7:04 pmBuffalo
Sep 26
BUF7:59 pmBuffalo
19h 56m
3 stops
PTY2:55 pmPanama City Tocumen Intl
$930
Avianca
Sep 11
PTY5:30 amPanama City Tocumen Intl
36h 34m
2 stops
BUF7:04 pmBuffalo
Sep 26
BUF7:59 pmBuffalo
19h 56m
3 stops
PTY2:55 pmPanama City Tocumen Intl
$964
Avianca
Sep 8
PTY3:50 pmPanama City Tocumen Intl
26h 12m
2 stops
BUF7:02 pmBuffalo
Sep 26
BUF7:59 pmBuffalo
19h 56m
3 stops
PTY2:55 pmPanama City Tocumen Intl
$973

United Airlines flights from Panama City to Buffalo

Our best United Airlines deals on Panama City to Buffalo flight tickets
United Airlines
Oct 26
PTY7:55 amPanama City Tocumen Intl
24h 47m
2 stops
BUF9:42 amBuffalo
Nov 9
BUF6:30 amBuffalo
13h 32m
2 stops
PTY8:02 pmPanama City Tocumen Intl
$736
United Airlines
Sep 8
PTY9:45 amPanama City Tocumen Intl
12h 59m
2 stops
BUF11:44 pmBuffalo
Sep 24
BUF6:00 amBuffalo
14h 31m
2 stops
PTY7:31 pmPanama City Tocumen Intl
$744
United Airlines
Oct 27
PTY7:55 amPanama City Tocumen Intl
24h 47m
2 stops
BUF9:42 amBuffalo
Oct 31
BUF10:51 amBuffalo
9h 11m
1 stop
PTY7:02 pmPanama City Tocumen Intl
$768

momondo Fare Finder

 
Customize your flight search to find flights from Panama City to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 5, 2026.
Use the filters below to find and compare flights from Panama City to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 10/18

3:50 pm-3:01 pm

2 stops22h 11m

Buffalo

Wed 10/28

8:00 pm-6:55 pm

2 stops23h 55m

$581
Quickest round-trip

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 10/18

3:50 pm-8:24 am

2 stops15h 34m

Buffalo

Wed 10/28

8:00 pm-2:55 pm

3 stops19h 55m

$588

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sun 10/18

11:25 am-3:01 pm

3 stops26h 36m

Buffalo

Wed 10/28

3:30 pm-2:55 pm

3 stops24h 25m

$594

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Sat 8/22

5:30 am-7:52 am

2 stops25h 22m

Buffalo

Sun 8/30

8:02 pm-1:55 am

2 stops30h 53m

$653

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 8/21

3:50 pm-7:22 am

2 stops14h 32m

Buffalo

Sun 8/30

8:02 pm-1:55 am

2 stops30h 53m

$657

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 9/10

5:30 am-2:43 pm

2 stops32h 13m

Buffalo

Fri 9/25

3:33 pm-10:30 am

2 stops19h 57m

$660

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Fri 8/21

11:25 am-7:22 am

3 stops18h 57m

Buffalo

Sun 8/30

8:02 pm-1:55 am

2 stops30h 53m

$667

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 8/17

3:50 pm-2:59 pm

2 stops22h 09m

Buffalo

Mon 8/24

8:07 pm-10:30 am

2 stops15h 23m

$691

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Thu 9/10

5:30 am-2:43 pm

2 stops32h 13m

Buffalo

Fri 9/25

7:50 pm-2:55 pm

3 stops20h 05m

$706

Panama CityBuffalo

PTY - BUF

PTYBUF

Panama City Tocumen Intl

Mon 10/26

7:55 am-9:42 am

2 stops24h 47m

Buffalo

Mon 11/9

6:30 am-8:02 pm

2 stops13h 32m

$736

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Panama City to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Panama City to Buffalo flights?

You could potentially save up to 4% on your flight if you consider stops on a Panama City to Buffalo flight.

When to book flights from Panama City to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Panama City to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Panama City to Buffalo (PTY to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Panama City to Buffalo

Fastest flight time

22h 11m

Direct flights

None
The fastest flight from Panama City to Buffalo takes 22h 11m
There are no direct flights from Panama City to Buffalo. There are no popular flight routes from Panama City to Buffalo.
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Frequently asked questions about flying from Panama City to Buffalo

  • How far is Panama City Tocumen Intl to Buffalo by plane?

    Buffalo is 2341.1 mi away from Panama City Tocumen Intl. Flights usually cover this in 22h 11m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Panama City Tocumen Intl Airport to Buffalo Airport?

    Prices for flights from Panama City Tocumen Intl Airport to Buffalo Airport refresh daily.

  • How old do you have to be to fly from Panama City Tocumen Intl Airport to Buffalo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Panama City Tocumen Intl Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The required travel and health documents for your Buffalo Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Buffalo Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Tonawanda
Williamsville
Orchard Park
Grand Island
Bowmansville
West Seneca
Lockport
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Panama City to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Panama City to Buffalo for you.

Can I find flights from Panama City to Buffalo with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Panama City to Buffalo flights to just show those with flexible booking policies.

How can momondo help me find flights from Panama City to Buffalo?

momondo helps you find the best flight between Panama City and Buffalo by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Panama City to Buffalo right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Buffalo from Panama City. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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