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Cheap flights from Chicago O'Hare Intl Airport to Knoxville from $127

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Chicago O'Hare Intl Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:00 am - 10:05 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
25h 05m1 stop Fort Lauderdale
Multiple Airlines Logo
2:12 pm - 10:43 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
9h 31m1 stop Philadelphia
$245Multiple Airlines
Fri, Oct 30 - Mon, Nov 2
Multiple Airlines Logo
8:04 am - 7:24 pmORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
10h 20m1 stop Fort Lauderdale
Multiple Airlines Logo
12:57 pm - 10:43 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
10h 46m1 stop Philadelphia
$272Multiple Airlines
Mon, Oct 26 - Fri, Oct 30
Multiple Airlines Logo
7:11 am - 10:05 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
25h 54m1 stop Fort Lauderdale
Multiple Airlines Logo
7:04 pm - 3:30 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
21h 26m1 stop Fort Lauderdale
$275Multiple Airlines
Tue, Oct 6 - Tue, Oct 13
American Airlines Logo
8:59 pm - 11:50 pmORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 51mnonstop
American Airlines Logo
7:49 am - 9:10 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
2h 21mnonstop
$279American Airlines
Thu, Dec 17 - Sat, Jan 9
American Airlines Logo
9:05 pm - 11:59 pmORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 54mnonstop
American Airlines Logo
11:35 am - 12:37 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
2h 02mnonstop
$279American Airlines
Thu, Oct 29 - Sat, Oct 31
United Airlines Logo
6:59 am - 9:45 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 46mnonstop
United Airlines Logo
6:00 am - 6:56 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
1h 56mnonstop
$279United Airlines
Thu, Oct 15 - Mon, Oct 19
United Airlines Logo
6:59 am - 9:45 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 46mnonstop
United Airlines Logo
6:00 am - 6:56 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
1h 56mnonstop
$279United Airlines
Thu, Oct 15 - Mon, Oct 19
American Airlines Logo
1:45 pm - 4:29 pmORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 44mnonstop
American Airlines Logo
8:52 pm - 9:58 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
2h 06mnonstop
$279American Airlines
Fri, Dec 4 - Sun, Dec 6
United Airlines Logo
6:59 am - 9:45 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
1h 46mnonstop
United Airlines Logo
6:00 am - 6:56 amTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
1h 56mnonstop
$279United Airlines
Tue, Oct 6 - Tue, Oct 13
Multiple Airlines Logo
7:11 am - 8:35 amORD  Chicago O'Hare Intl-TYS Knoxville McGhee Tyson
24h 24m1 stop Fort Lauderdale
Multiple Airlines Logo
6:55 pm - 10:39 pmTYS  Knoxville McGhee Tyson-ORD Chicago O'Hare Intl
28h 44m1 stop Philadelphia
$284Multiple Airlines
Fri, Oct 2 - Fri, Oct 9

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American Airlines flights from Chicago O'Hare Intl Airport to Knoxville

Our best American Airlines deals on Chicago O'Hare Intl Airport to Knoxville flight tickets
American Airlines
Oct 29
ORD9:05 pmChicago O'Hare Intl
1h 54m
TYS11:59 pmKnoxville McGhee Tyson
Oct 31
TYS11:35 amKnoxville McGhee Tyson
2h 02m
ORD12:37 pmChicago O'Hare Intl
$279
American Airlines
Sep 26
ORD4:50 pmChicago O'Hare Intl
1h 53m
TYS7:43 pmKnoxville McGhee Tyson
Sep 28
TYS8:15 pmKnoxville McGhee Tyson
2h 15m
ORD9:30 pmChicago O'Hare Intl
$280
American Airlines
Oct 23
ORD9:05 pmChicago O'Hare Intl
1h 54m
TYS11:59 pmKnoxville McGhee Tyson
Oct 30
TYS5:07 pmKnoxville McGhee Tyson
2h 02m
ORD6:09 pmChicago O'Hare Intl
$282

Delta flights from Chicago O'Hare Intl Airport to Knoxville

Our best Delta deals on Chicago O'Hare Intl Airport to Knoxville flight tickets
Delta
Nov 24
ORD11:19 amChicago O'Hare Intl
5h 30m
1 stop
TYS5:49 pmKnoxville McGhee Tyson
Nov 28
TYS5:10 pmKnoxville McGhee Tyson
4h 07m
1 stop
ORD8:17 pmChicago O'Hare Intl
$339
Delta
Sep 12
ORD3:40 pmChicago O'Hare Intl
5h 47m
1 stop
TYS10:27 pmKnoxville McGhee Tyson
Sep 15
TYS5:28 pmKnoxville McGhee Tyson
4h 02m
1 stop
ORD8:30 pmChicago O'Hare Intl
$404

momondo Fare Finder

 
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Knoxville that are best for you.

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Price

Cheapest round-trip

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Fri 10/30

8:00 am-10:05 am

1 stop25h 05m

Knoxville McGhee Tyson

Mon 11/2

2:12 pm-10:43 pm

1 stop9h 31m

$245

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Mon 10/26

8:04 am-7:24 pm

1 stop10h 20m

Knoxville McGhee Tyson

Fri 10/30

12:57 pm-10:43 pm

1 stop10h 46m

$272

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Tue 10/6

7:11 am-10:05 am

1 stop25h 54m

Knoxville McGhee Tyson

Tue 10/13

7:04 pm-3:30 pm

1 stop21h 26m

$275

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Thu 12/17

8:59 pm-11:50 pm

Nonstop1h 51m

Knoxville McGhee Tyson

Sat 1/9

7:49 am-9:10 am

Nonstop2h 21m

$279

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Thu 10/29

9:05 pm-11:59 pm

Nonstop1h 54m

Knoxville McGhee Tyson

Sat 10/31

11:35 am-12:37 pm

Nonstop2h 02m

$279
Quickest round-trip

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Thu 10/15

6:59 am-9:45 am

Nonstop1h 46m

Knoxville McGhee Tyson

Mon 10/19

6:00 am-6:56 am

Nonstop1h 56m

$279

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Thu 10/15

6:59 am-9:45 am

Nonstop1h 46m

Knoxville McGhee Tyson

Mon 10/19

6:00 am-6:56 am

Nonstop1h 56m

$279

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Fri 12/4

1:45 pm-4:29 pm

Nonstop1h 44m

Knoxville McGhee Tyson

Sun 12/6

8:52 pm-9:58 pm

Nonstop2h 06m

$279

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Tue 10/6

6:59 am-9:45 am

Nonstop1h 46m

Knoxville McGhee Tyson

Tue 10/13

6:00 am-6:56 am

Nonstop1h 56m

$279

ChicagoKnoxville

ORD Chicago O'Hare Intl - TYS Knoxville McGhee Tyson

ORDTYS

Chicago O'Hare Intl

Fri 10/2

7:11 am-8:35 am

1 stop24h 24m

Knoxville McGhee Tyson

Fri 10/9

6:55 pm-10:39 pm

1 stop28h 44m

$284

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago O'Hare Intl Airport and Knoxville?

Prices are currently low for flights on this route.

Typical prices usually range from $264 to $487.
The lowest price recently found on this route was $245.

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Chicago O'Hare Intl Airport, with most prices found around $289. If you aren’t able to travel during the month of August, then book flights to Knoxville from Chicago O'Hare Intl Airport during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $293.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago O'Hare Intl Airport to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $270. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Chicago O'Hare Intl Airport to Knoxville for around $408.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago O'Hare Intl Airport to Knoxville when you can find flight prices for as low as $239. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $343.

What is the cheapest Chicago O'Hare Intl to Knoxville McGhee Tyson flight route?

Fly from Chicago O'Hare Intl to Knoxville McGhee Tyson for the best Chicago O'Hare Intl - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight from Chicago O'Hare Intl Airport to Knoxville?

You are more likely to see cheaper flights to Knoxville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $330 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Chicago O'Hare Intl Airport for as low as $195 on momondo.

What cabin class options are available on Chicago O'Hare Intl Airport to Knoxville flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl Airport to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Chicago O'Hare Intl Airport to Knoxville.

How have Chicago O'Hare Intl Airport to Knoxville flight prices changed over time?

As of September 2026, prices for Chicago O'Hare Intl Airport to Knoxville flights are approximately 26% cheaper when compared to flights at the same time last year.

When to book flights from Chicago O'Hare Intl Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Knoxville (ORD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Knoxville

Best Price Found

$127

Fastest flight time

1h 39m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Chicago O'Hare Intl Airport in the past 72 hours is $127. The best round-trip flight deal from Chicago O'Hare Intl Airport to Knoxville found on momondo in the last 72 hours is $245.
The fastest flight from Chicago O'Hare Intl Airport to Knoxville takes 1h 39m
Direct flights go from Chicago O'Hare Intl Airport to Knoxville every day.
There is 1 airport in Knoxville. From Chicago O'Hare Intl Airport there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from Chicago O'Hare Intl Airport to Knoxville

  • How far is Chicago O'Hare Intl to Knoxville McGhee Tyson by plane?

    There are 467.2 mi between Chicago O'Hare Intl and Knoxville McGhee Tyson. Flights usually cover this in 1h 39m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to Knoxville?

  • What is the most popular airline from Chicago O'Hare Intl Airport to Knoxville?

Best airlines flying from Chicago O'Hare Intl Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $189Free CancellationRating
7.4
10,190 reviews
Search United Airlines flights
American AirlinesPriceFrom $207Free CancellationRating
7.1
12,045 reviews
Search American Airlines flights

  • United Airlines Flights From Chicago O'Hare Intl Airport to Knoxville

    United Airlines operates around 8 flights from Chicago O'Hare Intl Airport to Knoxville every week. The average price of these flights found in the last 72 hours has been $334, but momondo users have found United Airlines deals from Chicago O'Hare Intl Airport to Knoxville from as low as $189 round-trip. United Airlines has been scored 7.4/10 in 10,190 reviews.

  • American Airlines Flights From Chicago O'Hare Intl Airport to Knoxville

    American Airlines is also a popular choice for this route. American Airlines flight deals for Chicago O'Hare Intl Airport to Knoxville start from as low as $207 round-trip, depending on your selected dates, with average American Airlines deals seen on momondo around $331. American Airlines operates 7 flights to Knoxville from Chicago O'Hare Intl Airport in an average week. Users have rated it 7.1/10 across 12,045 reviews.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Clinton
Lenoir City
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Flights from Chicago to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Knoxville?

Once all potential Chicago to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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