Cheap flights from Chicago O'Hare Intl Airport to Knoxville from $115

The month of August is, on average, the cheapest month to fly to Knoxville from Chicago O'Hare Intl Airport, with most prices found around $274. If you aren’t able to travel during the month of August, then book flights to Knoxville from Chicago O'Hare Intl Airport during February instead. Flights to Knoxville in February, while not as cheap as those in August, still average around $293.

The cheapest day to depart from Chicago O'Hare Intl Airport to Knoxville is on a Thursday. Travelers who choose to depart for Knoxville on a Thursday will often find tickets for as low as $275. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Chicago O'Hare Intl Airport to Knoxville for around $426.

At noon is the cheapest time of day to fly from Chicago O'Hare Intl Airport to Knoxville when you can find flight prices for as low as $246. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $349.

Fly from Chicago O'Hare Intl to Knoxville McGhee Tyson for the best Chicago O'Hare Intl - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $342 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Chicago O'Hare Intl Airport for as low as $195 on momondo.

There are 4 cabin classes available to choose from on Chicago O'Hare Intl Airport to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

You could potentially save up to 23% on your flight if you consider stops on a Chicago O'Hare Intl Airport to Knoxville flight.

As of November 2026, prices for Chicago O'Hare Intl Airport to Knoxville flights are approximately 73% more expensive when compared to flights at the same time last year.

As of November 2026, there are 22 flights per day flying from Chicago O'Hare Intl Airport to Knoxville. The most common time of day flights depart is 9:00PM, with 43% of flights taking off in the afternoon.

As of November 2026, there are 160 flights per week flying from Chicago O'Hare Intl Airport to Knoxville. The most common day of the week flights depart is Mon, with 18% of flights taking off on this day.