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Cheap flights from Chicago O'Hare Intl Airport to Knoxville from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to Knoxville departing on 4/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Chicago O'Hare Intl Airport to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:27 pm - 8:42 pm
ORD
-
TYS
30h 15m
1 stop
Multiple Airlines Logo
4:25 pm - 12:24 am
TYS
-
ORD
8h 59m
1 stop
$197Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Southwest Logo
2:40 pm - 7:40 pm
ORD
-
TYS
4h 00m
1 stop
Southwest Logo
6:40 am - 3:30 pm
TYS
-
ORD
9h 50m
1 stop
$204Southwest
Tue, Apr 21 - Sat, Apr 25
Multiple Airlines Logo
7:15 pm - 10:36 am
ORD
-
TYS
14h 21m
1 stop
Multiple Airlines Logo
9:32 pm - 9:36 am
TYS
-
ORD
13h 04m
1 stop
$221Multiple Airlines
Tue, Apr 21 - Thu, Apr 23
Multiple Airlines Logo
1:27 pm - 2:45 pm
ORD
-
TYS
24h 18m
1 stop
Multiple Airlines Logo
4:25 pm - 10:23 am
TYS
-
ORD
18h 58m
2 stops
$224Multiple Airlines
Wed, Apr 15 - Wed, Apr 22
Multiple Airlines Logo
6:10 pm - 11:39 pm
ORD
-
TYS
28h 29m
1 stop
Multiple Airlines Logo
2:56 pm - 5:15 pm
TYS
-
ORD
27h 19m
1 stop
$229Multiple Airlines
Wed, Apr 1 - Tue, Apr 7
Multiple Airlines Logo
1:27 pm - 10:36 am
ORD
-
TYS
20h 09m
1 stop
Multiple Airlines Logo
9:32 pm - 9:36 am
TYS
-
ORD
13h 04m
1 stop
$231Multiple Airlines
Tue, Apr 21 - Sun, Apr 26
Multiple Airlines Logo
7:45 pm - 8:50 pm
ORD
-
TYS
24h 05m
1 stop
Multiple Airlines Logo
4:25 pm - 12:27 am
TYS
-
ORD
9h 02m
1 stop
$235Multiple Airlines
Wed, May 6 - Wed, May 13
Multiple Airlines Logo
1:27 pm - 8:42 pm
ORD
-
TYS
30h 15m
1 stop
Multiple Airlines Logo
11:56 am - 9:36 am
TYS
-
ORD
22h 40m
1 stop
$236Multiple Airlines
Wed, Apr 22 - Sat, May 2
Multiple Airlines Logo
7:15 pm - 10:36 am
ORD
-
TYS
14h 21m
1 stop
Multiple Airlines Logo
4:25 pm - 12:24 am
TYS
-
ORD
8h 59m
1 stop
$238Multiple Airlines
Tue, Apr 28 - Wed, Apr 29
Multiple Airlines Logo
7:15 pm - 10:36 am
ORD
-
TYS
14h 21m
1 stop
Multiple Airlines Logo
3:40 pm - 12:24 am
TYS
-
ORD
9h 44m
1 stop
$240Multiple Airlines
Tue, Apr 28 - Thu, Apr 30

Southwest flights from Chicago O'Hare Intl Airport to Knoxville

Our best Southwest deals on Chicago O'Hare Intl Airport to Knoxville flight tickets
Southwest
Apr 21
ORD2:40 pmChicago O'Hare Intl
4h 00m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
Apr 25
TYS6:40 amKnoxville McGhee Tyson
9h 50m
1 stop
ORD3:30 pmChicago O'Hare Intl
$204
Southwest
May 20
ORD5:55 amChicago O'Hare Intl
10h 15m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
May 27
TYS12:50 pmKnoxville McGhee Tyson
6h 35m
1 stop
ORD6:25 pmChicago O'Hare Intl
$254
Southwest
Apr 21
ORD2:40 pmChicago O'Hare Intl
4h 00m
1 stop
TYS7:40 pmKnoxville McGhee Tyson
Apr 25
TYS7:45 amKnoxville McGhee Tyson
8h 45m
2 stops
ORD3:30 pmChicago O'Hare Intl
$265

United Airlines flights from Chicago O'Hare Intl Airport to Knoxville

Our best United Airlines deals on Chicago O'Hare Intl Airport to Knoxville flight tickets
United Airlines
Apr 11
ORD7:50 pmChicago O'Hare Intl
1h 44m
TYS10:34 pmKnoxville McGhee Tyson
Apr 12
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
$249
United Airlines
Apr 10
ORD7:50 pmChicago O'Hare Intl
1h 44m
TYS10:34 pmKnoxville McGhee Tyson
Apr 12
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
$260
United Airlines
Apr 9
ORD7:50 pmChicago O'Hare Intl
1h 44m
TYS10:34 pmKnoxville McGhee Tyson
Apr 12
TYS7:00 amKnoxville McGhee Tyson
1h 55m
ORD7:55 amChicago O'Hare Intl
$263

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 4/15

1:27 pm-8:42 pm

1 stop30h 15m

Knoxville McGhee Tyson

Wed 4/22

4:25 pm-12:24 am

1 stop8h 59m

$197
Quickest round-trip

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Tue 4/21

2:40 pm-7:40 pm

1 stop4h 00m

Knoxville McGhee Tyson

Sat 4/25

6:40 am-3:30 pm

1 stop9h 50m

$204

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Tue 4/21

7:15 pm-10:36 am

1 stop14h 21m

Knoxville McGhee Tyson

Thu 4/23

9:32 pm-9:36 am

1 stop13h 04m

$221

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 4/15

1:27 pm-2:45 pm

1 stop24h 18m

Knoxville McGhee Tyson

Wed 4/22

4:25 pm-10:23 am

2 stops18h 58m

$224

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 4/1

6:10 pm-11:39 pm

1 stop28h 29m

Knoxville McGhee Tyson

Tue 4/7

2:56 pm-5:15 pm

1 stop27h 19m

$229

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Tue 4/21

1:27 pm-10:36 am

1 stop20h 09m

Knoxville McGhee Tyson

Sun 4/26

9:32 pm-9:36 am

1 stop13h 04m

$231

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 5/6

7:45 pm-8:50 pm

1 stop24h 05m

Knoxville McGhee Tyson

Wed 5/13

4:25 pm-12:27 am

1 stop9h 02m

$235

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Wed 4/22

1:27 pm-8:42 pm

1 stop30h 15m

Knoxville McGhee Tyson

Sat 5/2

11:56 am-9:36 am

1 stop22h 40m

$236

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Tue 4/28

7:15 pm-10:36 am

1 stop14h 21m

Knoxville McGhee Tyson

Wed 4/29

4:25 pm-12:24 am

1 stop8h 59m

$238

ChicagoKnoxville

ORD - TYS

ORDTYS

Chicago O'Hare Intl

Tue 4/28

7:15 pm-10:36 am

1 stop14h 21m

Knoxville McGhee Tyson

Thu 4/30

3:40 pm-12:24 am

1 stop9h 44m

$240

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Chicago O'Hare Intl Airport, with most prices found around $256. If you aren’t able to travel during the month of August, then book flights to Knoxville from Chicago O'Hare Intl Airport during April instead. Flights to Knoxville in April, while not as cheap as those in August, still average around $289.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago O'Hare Intl Airport to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $263. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago O'Hare Intl Airport to Knoxville for around $318.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Chicago O'Hare Intl Airport to Knoxville when you can find flight prices for as low as $264. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the afternoon when prices are around $304.

What is the cheapest Chicago O'Hare Intl to Knoxville McGhee Tyson flight route?

Fly from Chicago O'Hare Intl to Knoxville McGhee Tyson for the best Chicago O'Hare Intl - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $311 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Chicago O'Hare Intl Airport for as low as $197 on momondo.

What cabin class options are available on Chicago O'Hare Intl to Knoxville McGhee Tyson flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to Knoxville flights?

You could potentially save up to 6% on your flight if you consider stops on a Chicago O'Hare Intl Airport to Knoxville flight.

How have Chicago O'Hare Intl Airport to Knoxville flight prices changed over time?

As of March 2026, prices for Chicago O'Hare Intl Airport to Knoxville flights are approximately 32% cheaper when compared to flights at the same time last year.

When to book flights from Chicago O'Hare Intl Airport to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Knoxville (ORD to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Knoxville

Best Price Found

$168

Fastest flight time

1h 41m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Chicago O'Hare Intl Airport in the past 72 hours is $168. The best round-trip flight deal from Chicago O'Hare Intl Airport to Knoxville found on momondo in the last 72 hours is $246.
The fastest flight from Chicago O'Hare Intl Airport to Knoxville takes 1h 41m
Direct flights go from Chicago O'Hare Intl Airport to Knoxville every day.
There is 1 airport in Knoxville. From Chicago O'Hare Intl Airport there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • How far is Chicago O'Hare Intl to Knoxville McGhee Tyson by plane?

    There are 467.2 mi between Chicago O'Hare Intl and Knoxville McGhee Tyson. Flights usually cover this in 1h 41m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to Knoxville?

  • What is the most popular airline from Chicago O'Hare Intl Airport to Knoxville?

Best airlines flying from Chicago O'Hare Intl Airport to Knoxville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.9
8,319 reviews
Search Delta flights
United AirlinesPriceFrom $189Free CancellationRating
7.4
9,460 reviews
Search United Airlines flights
American AirlinesPriceFrom $189Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights

  • United Airlines Flights From Chicago O'Hare Intl Airport to Knoxville

    United Airlines operates around 26 flights from Chicago O'Hare Intl Airport to Knoxville every week. The average price of these flights found in the last 72 hours has been $308, but momondo users have found United Airlines deals from Chicago O'Hare Intl Airport to Knoxville from as low as $189 round-trip. United Airlines has been scored 7.4/10 in 9,460 reviews.

  • American Airlines Flights From Chicago O'Hare Intl Airport to Knoxville

    American Airlines is also a popular choice for this route. American Airlines flight deals for Chicago O'Hare Intl Airport to Knoxville start from as low as $189 round-trip, depending on your selected dates, with average American Airlines deals seen on momondo around $305. American Airlines operates 18 flights to Knoxville from Chicago O'Hare Intl Airport in an average week. Users have rated it 7.1/10 across 11,489 reviews.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Flights from Chicago to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Chicago to Knoxville?

Once all potential Chicago to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Chicago to Knoxville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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