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Cheap flights from Chicago O'Hare Intl Airport to Greenville from $91

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Chicago O'Hare Intl Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:55 am - 8:13 amORD  Chicago O'Hare Intl-GSP Greenville
23h 18m1 stop Fort Lauderdale
Multiple Airlines Logo
10:12 am - 6:45 pmGSP  Greenville-ORD Chicago O'Hare Intl
9h 33m2 stops Tampa Atlanta Hartsfield-Jackson
$301Multiple Airlines
Sun, Nov 15 - Thu, Nov 19
Multiple Airlines Logo
4:00 pm - 7:59 pmORD  Chicago O'Hare Intl-GSP Greenville
26h 59m2 stops Atlanta Hartsfield-Jackson Orlando
Multiple Airlines Logo
8:32 pm - 12:56 amGSP  Greenville-ORD Chicago O'Hare Intl
29h 24m1 stop Orlando
$303Multiple Airlines
Wed, Dec 16 - Mon, Dec 28
Multiple Airlines Logo
4:00 pm - 7:54 amORD  Chicago O'Hare Intl-GSP Greenville
14h 54m1 stop Fort Lauderdale
Multiple Airlines Logo
10:12 am - 9:40 pmGSP  Greenville-ORD Chicago O'Hare Intl
12h 28m2 stops Tampa Atlanta Hartsfield-Jackson
$304Multiple Airlines
Fri, Nov 27 - Thu, Dec 3
Multiple Airlines Logo
7:55 am - 8:13 amORD  Chicago O'Hare Intl-GSP Greenville
23h 18m1 stop Fort Lauderdale
Multiple Airlines Logo
2:42 pm - 6:30 pmGSP  Greenville-ORD Chicago O'Hare Intl
28h 48m2 stops Fort Lauderdale Atlanta Hartsfield-Jackson
$305Multiple Airlines
Sun, Nov 1 - Mon, Nov 2
American Airlines Logo
3:06 pm - 6:06 pmORD  Chicago O'Hare Intl-GSP Greenville
2h 00mnonstop
American Airlines Logo
6:42 pm - 8:13 pmGSP  Greenville-ORD Chicago O'Hare Intl
2h 31mnonstop
$339American Airlines
Sat, Nov 14 - Mon, Nov 16
American Airlines Logo
8:11 am - 11:13 amORD  Chicago O'Hare Intl-GSP Greenville
2h 02mnonstop
American Airlines Logo
6:00 am - 7:22 amGSP  Greenville-ORD Chicago O'Hare Intl
2h 22mnonstop
$339American Airlines
Mon, Dec 21 - Tue, Dec 29
United Airlines Logo
6:50 am - 9:51 amORD  Chicago O'Hare Intl-GSP Greenville
2h 01mnonstop
United Airlines Logo
6:20 am - 7:36 amGSP  Greenville-ORD Chicago O'Hare Intl
2h 16mnonstop
$339United Airlines
Tue, Nov 10 - Mon, Nov 23
United Airlines Logo
6:50 am - 9:52 amORD  Chicago O'Hare Intl-GSP Greenville
2h 02mnonstop
United Airlines Logo
5:29 pm - 7:05 pmGSP  Greenville-ORD Chicago O'Hare Intl
2h 36mnonstop
$339United Airlines
Tue, Dec 8 - Mon, Dec 21
American Airlines Logo
6:55 pm - 9:59 pmORD  Chicago O'Hare Intl-GSP Greenville
2h 04mnonstop
American Airlines Logo
6:42 pm - 8:13 pmGSP  Greenville-ORD Chicago O'Hare Intl
2h 31mnonstop
$339American Airlines
Fri, Nov 13 - Mon, Nov 16
United Airlines Logo
5:55 pm - 8:58 pmORD  Chicago O'Hare Intl-GSP Greenville
2h 03mnonstop
United Airlines Logo
5:37 pm - 7:00 pmGSP  Greenville-ORD Chicago O'Hare Intl
2h 23mnonstop
$339United Airlines
Sat, Nov 7 - Mon, Nov 9

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United Airlines flights from Chicago O'Hare Intl Airport to Greenville

Our best United Airlines deals on Chicago O'Hare Intl Airport to Greenville flight tickets
United Airlines
Dec 21
ORD8:52 amChicago O'Hare Intl
4h 23m
1 stop
GSP2:15 pmGreenville
Dec 28
GSP7:37 pmGreenville
5h 24m
1 stop
ORD12:01 amChicago O'Hare Intl
$374
United Airlines
Nov 6
ORD5:55 pmChicago O'Hare Intl
2h 03m
GSP8:58 pmGreenville
Nov 9
GSP10:42 amGreenville
2h 06m
ORD11:48 amChicago O'Hare Intl
$379
United Airlines
Nov 6
ORD5:55 pmChicago O'Hare Intl
2h 03m
GSP8:58 pmGreenville
Nov 8
GSP6:20 amGreenville
2h 16m
ORD7:36 amChicago O'Hare Intl
$408

American Airlines flights from Chicago O'Hare Intl Airport to Greenville

Our best American Airlines deals on Chicago O'Hare Intl Airport to Greenville flight tickets
American Airlines
Dec 22
ORD6:54 pmChicago O'Hare Intl
2h 02m
GSP9:56 pmGreenville
Dec 28
GSP8:36 pmGreenville
2h 24m
ORD10:00 pmChicago O'Hare Intl
$339
American Airlines
Dec 23
ORD4:59 pmChicago O'Hare Intl
2h 03m
GSP8:02 pmGreenville
Dec 28
GSP6:00 amGreenville
2h 22m
ORD7:22 amChicago O'Hare Intl
$342
American Airlines
Dec 22
ORD6:54 pmChicago O'Hare Intl
2h 02m
GSP9:56 pmGreenville
Dec 28
GSP8:28 pmGreenville
4h 46m
1 stop
ORD12:14 amChicago O'Hare Intl
$349

momondo Fare Finder

 
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Sun 11/15

7:55 am-8:13 am

1 stop23h 18m

Greenville

Thu 11/19

10:12 am-6:45 pm

2 stops9h 33m

$301

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Wed 12/16

4:00 pm-7:59 pm

2 stops26h 59m

Greenville

Mon 12/28

8:32 pm-12:56 am

1 stop29h 24m

$303

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Fri 11/27

4:00 pm-7:54 am

1 stop14h 54m

Greenville

Thu 12/3

10:12 am-9:40 pm

2 stops12h 28m

$304

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Sun 11/1

7:55 am-8:13 am

1 stop23h 18m

Greenville

Mon 11/2

2:42 pm-6:30 pm

2 stops28h 48m

$305

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Sat 11/14

3:06 pm-6:06 pm

Nonstop2h 00m

Greenville

Mon 11/16

6:42 pm-8:13 pm

Nonstop2h 31m

$339

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Mon 12/21

8:11 am-11:13 am

Nonstop2h 02m

Greenville

Tue 12/29

6:00 am-7:22 am

Nonstop2h 22m

$339
Quickest round-trip

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Tue 11/10

6:50 am-9:51 am

Nonstop2h 01m

Greenville

Mon 11/23

6:20 am-7:36 am

Nonstop2h 16m

$339

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Tue 12/8

6:50 am-9:52 am

Nonstop2h 02m

Greenville

Mon 12/21

5:29 pm-7:05 pm

Nonstop2h 36m

$339

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Fri 11/13

6:55 pm-9:59 pm

Nonstop2h 04m

Greenville

Mon 11/16

6:42 pm-8:13 pm

Nonstop2h 31m

$339

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Sat 11/7

5:55 pm-8:58 pm

Nonstop2h 03m

Greenville

Mon 11/9

5:37 pm-7:00 pm

Nonstop2h 23m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago O'Hare Intl Airport and Greenville?

Prices are currently typical for flights on this route.

Typical prices usually range from $298 to $424.
The lowest price recently found on this route was $301.

What is the cheapest month to fly to Greenville?

The month of December is another great option to travel to Greenville, with average flight prices from Chicago O'Hare Intl Airport averaging around $299.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago O'Hare Intl Airport. The lowest ticket price found for a Saturday departure recently was $304. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $400. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the afternoon. Flights from Chicago O'Hare Intl Airport to Greenville during this time can be as low as $319. Flights to Greenville are more costly at noon, with an average ticket price of $357. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Chicago O'Hare Intl to Greenville flight route?

Fly from Chicago O'Hare Intl to Greenville for the best Chicago O'Hare Intl - Greenville flight prices

How far in advance should I book a flight from Chicago O'Hare Intl Airport to Greenville?

You are more likely to see cheaper flights to Greenville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $332 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Chicago O'Hare Intl Airport for as low as $222 on momondo.

What cabin class options are available on Chicago O'Hare Intl Airport to Greenville flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl Airport to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to Greenville flights?

No. A direct flight is the cheapest option for a flight between Chicago O'Hare Intl Airport to Greenville.

How have Chicago O'Hare Intl Airport to Greenville flight prices changed over time?

As of October 2026, prices for Chicago O'Hare Intl Airport to Greenville flights are approximately 5% cheaper when compared to flights at the same time last year.

When to book flights from Chicago O'Hare Intl Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Greenville (ORD to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Greenville

Best Price Found

$91

Fastest flight time

1h 56m

Direct flights

Every day

Airports in Greenville

1 airport
The best one-way flight to Greenville from Chicago O'Hare Intl Airport in the past 72 hours is $91. The best round-trip flight deal from Chicago O'Hare Intl Airport to Greenville found on momondo in the last 72 hours is $301.
The fastest flight from Chicago O'Hare Intl Airport to Greenville takes 1h 56m
Direct flights go from Chicago O'Hare Intl Airport to Greenville every day.
There is 1 airport in Greenville. From Chicago O'Hare Intl Airport there are direct flights to Greenville (GSP).
Search flight deals

Frequently asked questions about flying from Chicago O'Hare Intl Airport to Greenville

  • How far is Chicago O'Hare Intl to Greenville by plane?

    Chicago O'Hare Intl and Greenville are 575.0 mi apart from one another. Typically, this will take 1h 56m by plane in normal conditions.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Greenville Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Greenville Airport?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to Greenville?

  • What is the most popular airline from Chicago O'Hare Intl Airport to Greenville?

Best airlines flying from Chicago O'Hare Intl Airport to Greenville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $209Free CancellationRating
7.0
12,186 reviews
Search American Airlines flights
United AirlinesPriceFrom $218Free CancellationRating
7.3
10,404 reviews
Search United Airlines flights

  • United Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    United Airlines flight deals from Chicago O'Hare Intl Airport to Greenville start from $218 round-trip. Over the 14 United Airlines flights for this route in a normal week, average airfare is usually $332 round-trip - but some users have found much cheaper deals with momondo.

  • American Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    The best American Airlines deal for Chicago O'Hare Intl Airport to Greenville flight tickets found on momondo in the last 72 hours was $209, round-trip. It should be noted that an average American Airlines flight deal for this route in this time was higher, at $318 round-trip. American Airlines operates 14 flights out of Chicago O'Hare Intl Airport into Greenville in an average week, so prices vary by time and availability. 12,186 American Airlines reviews by users on momondo have scored the airline at 7.0/10.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Greenwood
Simpsonville
Greer
Duncan
Seneca

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Chicago which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Chicago to Greenville?

momondo provides multiple filters to help you find the best flight to Greenville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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