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Cheap flights from Chicago O'Hare Intl Airport to Greenville from $85

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to Greenville departing on 2/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago O'Hare Intl Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
3:55 pm - 8:59 pm
ORD
-
GSP
28h 04m1 stop
Multiple Airlines Logo
9:48 am - 11:46 pm
GSP
-
ORD
14h 58m1 stop
$183Multiple Airlines
Thu, Jan 22 - Mon, Jan 26
Multiple Airlines Logo
7:20 am - 4:55 pm
ORD
-
GSP
8h 35m1 stop
Multiple Airlines Logo
9:48 am - 11:22 am
GSP
-
ORD
26h 34m1 stop
$184Multiple Airlines
Thu, Jan 29 - Mon, Feb 2
Multiple Airlines Logo
5:32 pm - 8:58 am
ORD
-
GSP
14h 26m1 stop
Multiple Airlines Logo
5:45 pm - 11:47 pm
GSP
-
ORD
7h 02m1 stop
$187Multiple Airlines
Thu, Jan 29 - Thu, Feb 5
Multiple Airlines Logo
7:20 am - 4:55 pm
ORD
-
GSP
8h 35m1 stop
Multiple Airlines Logo
5:45 pm - 11:47 pm
GSP
-
ORD
7h 02m1 stop
$188Multiple Airlines
Thu, Jan 29 - Thu, Feb 5
Multiple Airlines Logo
2:52 pm - 8:58 am
ORD
-
GSP
17h 06m1 stop
Multiple Airlines Logo
2:12 pm - 11:59 pm
GSP
-
ORD
10h 47m1 stop
$194Multiple Airlines
Thu, Feb 5 - Sun, Feb 8
United Airlines Logo
5:50 pm - 8:47 pm
ORD
-
GSP
1h 57mnonstop
United Airlines Logo
6:35 am - 7:56 am
GSP
-
ORD
2h 21mnonstop
$195United Airlines
Sat, Jan 17 - Sat, Jan 31
American Airlines Logo
7:22 pm - 10:14 pm
ORD
-
GSP
1h 52mnonstop
American Airlines Logo
7:14 am - 8:30 am
GSP
-
ORD
2h 16mnonstop
$196American Airlines
Sat, Mar 28 - Wed, Apr 1
United Airlines Logo
5:50 pm - 8:47 pm
ORD
-
GSP
1h 57mnonstop
United Airlines Logo
6:35 am - 7:56 am
GSP
-
ORD
2h 21mnonstop
$202United Airlines
Thu, Jan 22 - Tue, Jan 27
American Airlines Logo
8:50 pm - 11:42 pm
ORD
-
GSP
1h 52mnonstop
American Airlines Logo
7:29 am - 8:45 am
GSP
-
ORD
2h 16mnonstop
$203American Airlines
Thu, Feb 26 - Sat, Feb 28
United Airlines Logo
7:10 am - 10:16 am
ORD
-
GSP
2h 06mnonstop
United Airlines Logo
10:00 am - 2:25 pm
GSP
-
ORD
5h 25m1 stop
$205United Airlines
Sat, Jan 17 - Sat, Jan 31

American Airlines flights from Chicago O'Hare Intl Airport to Greenville

Our best American Airlines deals on Chicago O'Hare Intl Airport to Greenville flight tickets
American Airlines
Mar 28
ORD7:22 pmChicago O'Hare Intl
1h 52m
GSP10:14 pmGreenville
Apr 1
GSP7:14 amGreenville
2h 16m
ORD8:30 amChicago O'Hare Intl
$196
Find similar
American Airlines
Feb 26
ORD8:50 pmChicago O'Hare Intl
1h 52m
GSP11:42 pmGreenville
Feb 28
GSP7:29 amGreenville
2h 16m
ORD8:45 amChicago O'Hare Intl
$203
Find similar
American Airlines
Jan 25
ORD9:07 pmChicago O'Hare Intl
1h 52m
GSP11:59 pmGreenville
Feb 1
GSP7:50 amGreenville
2h 20m
ORD9:10 amChicago O'Hare Intl
$210
Find similar

Delta flights from Chicago O'Hare Intl Airport to Greenville

Our best Delta deals on Chicago O'Hare Intl Airport to Greenville flight tickets
Delta
May 23
ORD9:30 amChicago O'Hare Intl
4h 23m
1 stop
GSP2:53 pmGreenville
May 27
GSP3:00 pmGreenville
6h 45m
1 stop
ORD8:45 pmChicago O'Hare Intl
$215
Find similar
Delta
May 21
ORD7:10 amChicago O'Hare Intl
6h 43m
1 stop
GSP2:53 pmGreenville
May 27
GSP5:45 amGreenville
3h 49m
1 stop
ORD8:34 amChicago O'Hare Intl
$222
Find similar
Delta
May 21
ORD7:10 amChicago O'Hare Intl
6h 43m
1 stop
GSP2:53 pmGreenville
May 28
GSP7:15 amGreenville
6h 24m
1 stop
ORD12:39 pmChicago O'Hare Intl
$229
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 2, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 1/22

3:55 pm-8:59 pm

1 stop28h 04m

Greenville

Mon 1/26

9:48 am-11:46 pm

1 stop14h 58m

$183

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 1/29

7:20 am-4:55 pm

1 stop8h 35m

Greenville

Mon 2/2

9:48 am-11:22 am

1 stop26h 34m

$184

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 1/29

5:32 pm-8:58 am

1 stop14h 26m

Greenville

Thu 2/5

5:45 pm-11:47 pm

1 stop7h 02m

$187

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 1/29

7:20 am-4:55 pm

1 stop8h 35m

Greenville

Thu 2/5

5:45 pm-11:47 pm

1 stop7h 02m

$188

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 2/5

2:52 pm-8:58 am

1 stop17h 06m

Greenville

Sun 2/8

2:12 pm-11:59 pm

1 stop10h 47m

$194

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 1/17

5:50 pm-8:47 pm

Nonstop1h 57m

Greenville

Sat 1/31

6:35 am-7:56 am

Nonstop2h 21m

$195

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 3/28

7:22 pm-10:14 pm

Nonstop1h 52m

Greenville

Wed 4/1

7:14 am-8:30 am

Nonstop2h 16m

$196

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 1/22

5:50 pm-8:47 pm

Nonstop1h 57m

Greenville

Tue 1/27

6:35 am-7:56 am

Nonstop2h 21m

$202

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 2/26

8:50 pm-11:42 pm

Nonstop1h 52m

Greenville

Sat 2/28

7:29 am-8:45 am

Nonstop2h 16m

$203

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 1/17

7:10 am-10:16 am

Nonstop2h 06m

Greenville

Sat 1/31

10:00 am-2:25 pm

1 stop5h 25m

$205

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of July is another great option to travel to Greenville, with average flight prices from Chicago O'Hare Intl Airport averaging around $279.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago O'Hare Intl Airport. The lowest ticket price found for a Saturday departure recently was $273. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $418. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Chicago O'Hare Intl Airport to Greenville during this time can be as low as $290. Flights to Greenville are more costly in the evening, with an average ticket price of $315. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Chicago O'Hare Intl to Greenville flight route?

Fly from Chicago O'Hare Intl to Greenville for the best Chicago O'Hare Intl - Greenville flight prices

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $305 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Chicago O'Hare Intl Airport for as low as $230 on momondo.

What cabin class options are available on Chicago O'Hare Intl to Greenville flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to Greenville flights?

You could potentially save up to 7% on your flight if you consider stops on a Chicago O'Hare Intl Airport to Greenville flight.

How have Chicago O'Hare Intl Airport to Greenville flight prices changed over time?

As of January 2026, prices for Chicago O'Hare Intl Airport to Greenville flights are approximately 0% more expensive when compared to flights at the same time last year.

When to book flights from Chicago O'Hare Intl Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Greenville (ORD to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Greenville

Best Price Found

$183

Fastest flight time

1h 56m

Direct flights

Mon, Wed, Thu, Fri, Sat and Sun

Airports in Greenville

1 airport
The best one-way flight to Greenville from Chicago O'Hare Intl Airport in the past 72 hours is $183. The best round-trip flight deal from Chicago O'Hare Intl Airport to Greenville found on momondo in the last 72 hours is $245.
The fastest flight from Chicago O'Hare Intl Airport to Greenville takes 1h 56m
Direct flights go from Chicago O'Hare Intl Airport to Greenville on Monday, Wednesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport in Greenville. From Chicago O'Hare Intl Airport there are direct flights to Greenville (GSP).
Search flight deals

  • How far is Chicago O'Hare Intl to Greenville by plane?

    Chicago O'Hare Intl and Greenville are 575.0 mi apart from one another. Typically, this will take 1h 56m by plane in normal conditions.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Greenville Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Greenville Airport?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to Greenville?

  • What is the most popular airline from Chicago O'Hare Intl Airport to Greenville?

Best airlines flying from Chicago O'Hare Intl Airport to Greenville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.9
8,021 reviews
Search Delta flights
American AirlinesPriceFrom $202Free CancellationRating
7.2
11,075 reviews
Search American Airlines flights
United AirlinesPriceFrom $211Free CancellationRating
7.4
9,132 reviews
Search United Airlines flights

  • United Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    United Airlines flight deals from Chicago O'Hare Intl Airport to Greenville start from $211 round-trip. Over the 16 United Airlines flights for this route in a normal week, average airfare is usually $339 round-trip - but some users have found much cheaper deals with momondo.

  • American Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    The best American Airlines deal for Chicago O'Hare Intl Airport to Greenville flight tickets found on momondo in the last 72 hours was $202, round-trip. It should be noted that an average American Airlines flight deal for this route in this time was higher, at $288 round-trip. American Airlines operates 12 flights out of Chicago O'Hare Intl Airport into Greenville in an average week, so prices vary by time and availability. 11,074 American Airlines reviews by users on momondo have scored the airline at 7.2/10.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Chicago which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Chicago to Greenville?

momondo provides multiple filters to help you find the best flight to Greenville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Greenville trip

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