What is the cheapest airline that flies from Chicago O'Hare Intl to Greenville?

American Airlines and Delta are the most popular carriers operating from Chicago O'Hare Intl to Greenville

How many flights depart from Chicago O'Hare Intl Airport to Greenville on average per day?

As of February 2026, 12 flights take off from Chicago O'Hare Intl Airport and land in Greenville each day. The most common flight departure time for this route is 5:00PM, with 61% of daily flights taking off in the afternoon.

What airlines fly to Greenville?

American Airlines, United Airlines and Frontier are the top three most popular airlines that fly to Greenville from Chicago O'Hare Intl Airport according to our data. American Airlines is the first choice among our users, with 52% of people opting to fly with this airline when traveling to Greenville. Keep in mind that there are 5 different airlines that fly to Greenville on a routine basis, so you have a few additional options to choose from.

How many flights depart from Chicago O'Hare Intl Airport to Greenville on average per week?

As of February 2026, there are 89 flights per week flying from Chicago O'Hare Intl Airport to Greenville. The most common day of the week flights depart is Fri, with 19% of flights taking off on this day.

When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Greenville Airport?

Prices for flights from Chicago O'Hare Intl Airport to Greenville Airport were last updated today.

How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Greenville Airport?

As of February 2026, there are 3 operators available to choose from for flights from Chicago O'Hare Intl Airport to Greenville Airport.

How old do you have to be to fly from Chicago O'Hare Intl Airport to Greenville Airport?

The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Greenville Airport.

What documentation or ID do you need to fly to Greenville Airport?

The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

$104 Cheap Flights from Chicago O'Hare Intl Airport to Greenville in 2026

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Find the cheapest flights from Chicago O'Hare Intl Airport to Greenville

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:05 am - 10:01 am

ORD

GSP

1h 56mnonstop

10:36 am - 11:53 am

GSP

ORD

2h 17mnonstop

$209United Airlines

Wed, Mar 25 - Mon, Mar 30

2:59 pm - 9:52 pm

ORD

GSP

5h 53m

1 stop

5:40 am - 8:30 am

GSP

ORD

3h 50m

1 stop

$213Delta

Sat, Mar 14 - Sat, Mar 21

1:06 pm - 7:28 pm

ORD

GSP

5h 22m

1 stop

6:30 am - 7:54 am

GSP

ORD

2h 24mnonstop

$219United Airlines

Wed, Mar 25 - Mon, Mar 30

8:50 pm - 11:42 pm

ORD

GSP

1h 52mnonstop

8:17 pm - 9:36 pm

GSP

ORD

2h 19mnonstop

$224American Airlines

Wed, Mar 18 - Sun, Mar 22

11:10 am - 6:54 pm

ORD

GSP

6h 44m

1 stop

7:59 pm - 11:59 pm

GSP

ORD

5h 00m

1 stop

$228Delta

Thu, Apr 9 - Mon, Apr 13

8:50 am - 2:17 pm

ORD

GSP

4h 27m

1 stop

10:00 am - 2:33 pm

GSP

ORD

5h 33m

1 stop

$229United Airlines

Tue, Mar 17 - Wed, Mar 18

1:06 pm - 7:28 pm

ORD

GSP

5h 22m

1 stop

10:36 am - 11:53 am

GSP

ORD

2h 17mnonstop

$230United Airlines

Wed, Mar 25 - Mon, Mar 30

6:10 pm - 9:48 am

ORD

GSP

38h 38m

2 stops

5:43 pm - 11:22 am

GSP

ORD

18h 39m

1 stop

$231Multiple Airlines

Tue, Apr 14 - Mon, Apr 20

5:05 am - 4:53 pm

ORD

GSP

10h 48m

1 stop

5:43 pm - 9:17 pm

GSP

ORD

28h 34m

1 stop

$232Multiple Airlines

Fri, May 8 - Mon, May 11

6:00 am - 12:14 pm

ORD

GSP

5h 14m

1 stop

8:17 pm - 9:36 pm

GSP

ORD

2h 19mnonstop

$234American Airlines

Wed, Mar 18 - Sun, Mar 22

Delta flights from Chicago O'Hare Intl Airport to Greenville

Our best Delta deals on Chicago O'Hare Intl Airport to Greenville flight tickets

Delta

Mar 14

ORD2:59 pmChicago O'Hare Intl

5h 53m

1 stop

GSP9:52 pmGreenville

Mar 21

GSP5:40 amGreenville

3h 50m

1 stop

ORD8:30 amChicago O'Hare Intl

$213

Delta

Apr 9

ORD11:10 amChicago O'Hare Intl

6h 44m

1 stop

GSP6:54 pmGreenville

Apr 13

GSP7:59 pmGreenville

5h 00m

1 stop

ORD11:59 pmChicago O'Hare Intl

$228

Delta

Mar 24

ORD10:45 amChicago O'Hare Intl

5h 56m

1 stop

GSP5:41 pmGreenville

Mar 27

GSP5:40 amGreenville

3h 50m

1 stop

ORD8:30 amChicago O'Hare Intl

$262

United Airlines flights from Chicago O'Hare Intl Airport to Greenville

Our best United Airlines deals on Chicago O'Hare Intl Airport to Greenville flight tickets

United Airlines

Mar 25

ORD7:05 amChicago O'Hare Intl

1h 56m

GSP10:01 amGreenville

Mar 30

GSP10:36 amGreenville

2h 17m

ORD11:53 amChicago O'Hare Intl

$209

United Airlines

Mar 25

ORD1:06 pmChicago O'Hare Intl

5h 22m

1 stop

GSP7:28 pmGreenville

Mar 30

GSP6:30 amGreenville

2h 24m

ORD7:54 amChicago O'Hare Intl

$219

United Airlines

Mar 17

ORD8:50 amChicago O'Hare Intl

4h 27m

1 stop

GSP2:17 pmGreenville

Mar 18

GSP10:00 amGreenville

5h 33m

1 stop

ORD2:33 pmChicago O'Hare Intl

$229

momondo Fare Finder

Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 3/25

7:05 am-10:01 am

Nonstop1h 56m

Greenville

Mon 3/30

10:36 am-11:53 am

Nonstop2h 17m

$209

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 3/14

2:59 pm-9:52 pm

1 stop5h 53m

Greenville

Sat 3/21

5:40 am-8:30 am

1 stop3h 50m

$213

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 3/25

1:06 pm-7:28 pm

1 stop5h 22m

Greenville

Mon 3/30

6:30 am-7:54 am

Nonstop2h 24m

$219

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 3/18

8:50 pm-11:42 pm

Nonstop1h 52m

Greenville

Sun 3/22

8:17 pm-9:36 pm

Nonstop2h 19m

$224

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 4/9

11:10 am-6:54 pm

1 stop6h 44m

Greenville

Mon 4/13

7:59 pm-11:59 pm

1 stop5h 00m

$228

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Tue 3/17

8:50 am-2:17 pm

1 stop4h 27m

Greenville

Wed 3/18

10:00 am-2:33 pm

1 stop5h 33m

$229

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 3/25

1:06 pm-7:28 pm

1 stop5h 22m

Greenville

Mon 3/30

10:36 am-11:53 am

Nonstop2h 17m

$230

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Tue 4/14

6:10 pm-9:48 am

2 stops38h 38m

Greenville

Mon 4/20

5:43 pm-11:22 am

1 stop18h 39m

$231

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Fri 5/8

5:05 am-4:53 pm

1 stop10h 48m

Greenville

Mon 5/11

5:43 pm-9:17 pm

1 stop28h 34m

$232

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 3/18

6:00 am-12:14 pm

1 stop5h 14m

Greenville

Sun 3/22

8:17 pm-9:36 pm

Nonstop2h 19m

$234

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Greenville?

The month of July is another great option to travel to Greenville, with average flight prices from Chicago O'Hare Intl Airport averaging around $279.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago O'Hare Intl Airport. The lowest ticket price found for a Saturday departure recently was $267. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $374. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Chicago O'Hare Intl Airport to Greenville during this time can be as low as $288. Flights to Greenville are more costly in the evening, with an average ticket price of $320. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Chicago O'Hare Intl to Greenville flight route?

Fly from Chicago O'Hare Intl to Greenville for the best Chicago O'Hare Intl - Greenville flight prices

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $299 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Chicago O'Hare Intl Airport for as low as $222 on momondo.

What cabin class options are available on Chicago O'Hare Intl to Greenville flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to Greenville flights?

No. A direct flight is the cheapest option for a flight between Chicago O'Hare Intl Airport to Greenville.

How have Chicago O'Hare Intl Airport to Greenville flight prices changed over time?

As of February 2026, prices for Chicago O'Hare Intl Airport to Greenville flights are approximately 2% more expensive when compared to flights at the same time last year.

When to book flights from Chicago O'Hare Intl Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Greenville (ORD to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Greenville

Best Price Found	$143
Fastest flight time	1h 52m
Direct flights	Every day
Airports in Greenville	1 airport

The best one-way flight to Greenville from Chicago O'Hare Intl Airport in the past 72 hours is $143. The best round-trip flight deal from Chicago O'Hare Intl Airport to Greenville found on momondo in the last 72 hours is $260.

The fastest flight from Chicago O'Hare Intl Airport to Greenville takes 1h 52m

Direct flights go from Chicago O'Hare Intl Airport to Greenville every day.

There is 1 airport in Greenville. From Chicago O'Hare Intl Airport there are direct flights to Greenville (GSP).

Search flight deals

How far is Chicago O'Hare Intl to Greenville by plane?
Chicago O'Hare Intl and Greenville are 575.0 mi apart from one another. Typically, this will take 1h 52m by plane in normal conditions.
When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Greenville Airport?
Prices for flights from Chicago O'Hare Intl Airport to Greenville Airport were last updated today.
How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Greenville Airport?
As of February 2026, there are 3 operators available to choose from for flights from Chicago O'Hare Intl Airport to Greenville Airport.
How old do you have to be to fly from Chicago O'Hare Intl Airport to Greenville Airport?
The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Greenville Airport.
What documentation or ID do you need to fly to Greenville Airport?
The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.
What is the most popular plane model from Chicago O'Hare Intl Airport to Greenville?
Based on momondo bookings for flights between Chicago O'Hare Intl Airport and Greenville, the leading plane model is Embraer 175 (Enhanced Winglets), making up 25.11% of the total bookings. Other popular models include Canadair (Bombardier) Regional Jet CRJ-550 with 22.81%, Embraer 170 with 22.15%, and Embraer 175 with 17.11%.
What is the most popular airline from Chicago O'Hare Intl Airport to Greenville?
momondo data reveals that the most frequently booked airline on the route from Chicago O'Hare Intl Airport to Greenville is American Airlines, representing 61% of all bookings. The subsequent popular airlines are United Airlines at 37% and Delta at 2%.

Best airlines flying from Chicago O'Hare Intl Airport to Greenville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Greenville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $146	Free Cancellation	Rating 7.9 8,245 reviews	Search Delta flights
American Airlines	PriceFrom $202	Free Cancellation	Rating 7.1 11,367 reviews	Search American Airlines flights
United Airlines	PriceFrom $209	Free Cancellation	Rating 7.4 9,363 reviews	Search United Airlines flights

United Airlines Flights From Chicago O'Hare Intl Airport to Greenville
United Airlines flight deals from Chicago O'Hare Intl Airport to Greenville start from $209 round-trip. Over the 12 United Airlines flights for this route in a normal week, average airfare is usually $329 round-trip - but some users have found much cheaper deals with momondo.
American Airlines Flights From Chicago O'Hare Intl Airport to Greenville
The best American Airlines deal for Chicago O'Hare Intl Airport to Greenville flight tickets found on momondo in the last 72 hours was $202, round-trip. It should be noted that an average American Airlines flight deal for this route in this time was higher, at $285 round-trip. American Airlines operates 13 flights out of Chicago O'Hare Intl Airport into Greenville in an average week, so prices vary by time and availability. 11,367 American Airlines reviews by users on momondo have scored the airline at 7.1/10.

Anderson

Simpsonville

Greenwood

Greer

Seneca

Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Chicago which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Chicago to Greenville?

momondo provides multiple filters to help you find the best flight to Greenville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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Cheap flights from Chicago O'Hare Intl Airport to Greenville from $104

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Delta flights from Chicago O'Hare Intl Airport to Greenville

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Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Greenville that are best for you.

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How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Greenville

What is the cheapest month to fly to Greenville?

What is the cheapest day to depart on your flight to Greenville?

What is the cheapest time of day to depart on your flight to Greenville?

What is the cheapest Chicago O'Hare Intl to Greenville flight route?

How far in advance should I book a flight to Greenville?

What cabin class options are available on Chicago O'Hare Intl to Greenville flights?

Can stopping save me money on Chicago O'Hare Intl Airport to Greenville flights?

How have Chicago O'Hare Intl Airport to Greenville flight prices changed over time?

What is the cheapest airline that flies from Chicago O'Hare Intl to Greenville?

What airlines fly to Greenville?

How many flights depart from Chicago O'Hare Intl Airport to Greenville on average per day?

How many flights depart from Chicago O'Hare Intl Airport to Greenville on average per week?

When to book flights from Chicago O'Hare Intl Airport to Greenville

Cheap Chicago O'Hare Intl Airport to Greenville (ORD to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Greenville

Best Price Found

Fastest flight time

Direct flights

Airports in Greenville

Best airlines flying from Chicago O'Hare Intl Airport to Greenville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Greenville with momondo

United Airlines Flights From Chicago O'Hare Intl Airport to Greenville

American Airlines Flights From Chicago O'Hare Intl Airport to Greenville

Traveling to a place near Greenville?

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An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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