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Cheap flights from Chicago O'Hare Intl Airport to Greenville from $114

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Chicago O'Hare Intl Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:52 pm - 2:52 pmORD  Chicago O'Hare Intl-GSP Greenville
23h 00m2 stops Baltimore/Washington Orlando
Multiple Airlines Logo
2:42 pm - 11:34 pmGSP  Greenville-ORD Chicago O'Hare Intl
9h 52m1 stop Fort Lauderdale
$299Multiple Airlines
Sat, Nov 21 - Mon, Nov 23
Multiple Airlines Logo
4:00 pm - 8:13 amORD  Chicago O'Hare Intl-GSP Greenville
15h 13m1 stop Fort Lauderdale
Multiple Airlines Logo
11:28 am - 1:52 pmGSP  Greenville-ORD Chicago O'Hare Intl
27h 24m2 stops Tampa Atlanta Hartsfield-Jackson
$299Multiple Airlines
Thu, Nov 26 - Tue, Dec 1
Multiple Airlines Logo
4:00 pm - 7:54 amORD  Chicago O'Hare Intl-GSP Greenville
14h 54m1 stop Fort Lauderdale
Multiple Airlines Logo
8:52 pm - 2:30 pmGSP  Greenville-ORD Chicago O'Hare Intl
18h 38m2 stops Tampa Atlanta Hartsfield-Jackson
$302Multiple Airlines
Fri, Nov 27 - Fri, Dec 4
Multiple Airlines Logo
7:55 am - 8:12 pmORD  Chicago O'Hare Intl-GSP Greenville
11h 17m2 stops Fort Lauderdale Tampa
Multiple Airlines Logo
2:42 pm - 3:37 pmGSP  Greenville-ORD Chicago O'Hare Intl
25h 55m1 stop Fort Lauderdale
$302Multiple Airlines
Mon, Nov 9 - Fri, Nov 13
American Airlines Logo
2:52 pm - 8:50 pmORD  Chicago O'Hare Intl-GSP Greenville
4h 58m1 stop Washington, D.C. Reagan-National
American Airlines Logo
7:01 am - 8:35 amGSP  Greenville-ORD Chicago O'Hare Intl
2h 34mnonstop
$307American Airlines
Mon, Nov 23 - Fri, Nov 27
American Airlines Logo
12:55 pm - 8:48 pmORD  Chicago O'Hare Intl-GSP Greenville
6h 53m1 stop Washington, D.C. Reagan-National
American Airlines Logo
6:47 pm - 8:15 pmGSP  Greenville-ORD Chicago O'Hare Intl
2h 28mnonstop
$307American Airlines
Wed, Dec 2 - Fri, Dec 4
American Airlines Logo
8:02 am - 11:07 amORD  Chicago O'Hare Intl-GSP Greenville
2h 05mnonstop
American Airlines Logo
6:27 pm - 7:59 pmGSP  Greenville-ORD Chicago O'Hare Intl
2h 32mnonstop
$308American Airlines
Sun, Nov 22 - Wed, Nov 25
United Airlines Logo
8:50 am - 2:16 pmORD  Chicago O'Hare Intl-GSP Greenville
4h 26m1 stop Washington, D.C. Dulles Intl
United Airlines Logo
6:20 am - 7:36 amGSP  Greenville-ORD Chicago O'Hare Intl
2h 16mnonstop
$329United Airlines
Thu, Nov 19 - Sun, Nov 22
United Airlines Logo
6:29 am - 9:30 amORD  Chicago O'Hare Intl-GSP Greenville
2h 01mnonstop
United Airlines Logo
7:43 pm - 12:01 amGSP  Greenville-ORD Chicago O'Hare Intl
5h 18m1 stop Washington, D.C. Dulles Intl
$333United Airlines
Fri, Nov 20 - Mon, Nov 23
United Airlines Logo
5:55 pm - 8:58 pmORD  Chicago O'Hare Intl-GSP Greenville
2h 03mnonstop
United Airlines Logo
6:30 am - 7:46 amGSP  Greenville-ORD Chicago O'Hare Intl
2h 16mnonstop
$336United Airlines
Wed, Nov 25 - Wed, Dec 2

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American Airlines flights from Chicago O'Hare Intl Airport to Greenville

Our best American Airlines deals on Chicago O'Hare Intl Airport to Greenville flight tickets
American Airlines
Nov 23
ORD2:52 pmChicago O'Hare Intl
4h 58m
1 stop
GSP8:50 pmGreenville
Nov 27
GSP7:01 amGreenville
2h 34m
ORD8:35 amChicago O'Hare Intl
$307
American Airlines
Dec 16
ORD6:54 pmChicago O'Hare Intl
2h 02m
GSP9:56 pmGreenville
Dec 18
GSP8:36 pmGreenville
2h 24m
ORD10:00 pmChicago O'Hare Intl
$308
American Airlines
Nov 23
ORD5:19 amChicago O'Hare Intl
5h 48m
1 stop
GSP12:07 pmGreenville
Nov 27
GSP6:50 amGreenville
5h 54m
1 stop
ORD11:44 amChicago O'Hare Intl
$317

United Airlines flights from Chicago O'Hare Intl Airport to Greenville

Our best United Airlines deals on Chicago O'Hare Intl Airport to Greenville flight tickets
United Airlines
Nov 20
ORD6:29 amChicago O'Hare Intl
2h 01m
GSP9:30 amGreenville
Nov 23
GSP7:43 pmGreenville
5h 18m
1 stop
ORD12:01 amChicago O'Hare Intl
$333
United Airlines
Nov 25
ORD5:55 pmChicago O'Hare Intl
2h 03m
GSP8:58 pmGreenville
Dec 2
GSP7:48 pmGreenville
4h 41m
1 stop
ORD11:29 pmChicago O'Hare Intl
$346
United Airlines
Nov 25
ORD1:30 pmChicago O'Hare Intl
4h 31m
1 stop
GSP7:01 pmGreenville
Dec 2
GSP7:48 pmGreenville
4h 41m
1 stop
ORD11:29 pmChicago O'Hare Intl
$361

momondo Fare Finder

 
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Sat 11/21

2:52 pm-2:52 pm

2 stops23h 00m

Greenville

Mon 11/23

2:42 pm-11:34 pm

1 stop9h 52m

$299

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Thu 11/26

4:00 pm-8:13 am

1 stop15h 13m

Greenville

Tue 12/1

11:28 am-1:52 pm

2 stops27h 24m

$299

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Fri 11/27

4:00 pm-7:54 am

1 stop14h 54m

Greenville

Fri 12/4

8:52 pm-2:30 pm

2 stops18h 38m

$302

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Mon 11/9

7:55 am-8:12 pm

2 stops11h 17m

Greenville

Fri 11/13

2:42 pm-3:37 pm

1 stop25h 55m

$302

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Mon 11/23

2:52 pm-8:50 pm

1 stop4h 58m

Greenville

Fri 11/27

7:01 am-8:35 am

Nonstop2h 34m

$307

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Wed 12/2

12:55 pm-8:48 pm

1 stop6h 53m

Greenville

Fri 12/4

6:47 pm-8:15 pm

Nonstop2h 28m

$307

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Sun 11/22

8:02 am-11:07 am

Nonstop2h 05m

Greenville

Wed 11/25

6:27 pm-7:59 pm

Nonstop2h 32m

$308

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Thu 11/19

8:50 am-2:16 pm

1 stop4h 26m

Greenville

Sun 11/22

6:20 am-7:36 am

Nonstop2h 16m

$329

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Fri 11/20

6:29 am-9:30 am

Nonstop2h 01m

Greenville

Mon 11/23

7:43 pm-12:01 am

1 stop5h 18m

$333
Quickest round-trip

ChicagoGreenville

ORD Chicago O'Hare Intl - GSP Greenville

ORDGSP

Chicago O'Hare Intl

Wed 11/25

5:55 pm-8:58 pm

Nonstop2h 03m

Greenville

Wed 12/2

6:30 am-7:46 am

Nonstop2h 16m

$336

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago O'Hare Intl Airport and Greenville?

Prices are currently typical for flights on this route.

Typical prices usually range from $283 to $434.
The lowest price recently found on this route was $299.

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Chicago O'Hare Intl Airport averaging around $302.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago O'Hare Intl Airport. The lowest ticket price found for a Saturday departure recently was $306. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $401. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the afternoon. Flights from Chicago O'Hare Intl Airport to Greenville during this time can be as low as $319. Flights to Greenville are more costly at noon, with an average ticket price of $370. Departure times at noon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Chicago O'Hare Intl to Greenville flight route?

Fly from Chicago O'Hare Intl to Greenville for the best Chicago O'Hare Intl - Greenville flight prices

How far in advance should I book a flight from Chicago O'Hare Intl Airport to Greenville?

You are more likely to see cheaper flights to Greenville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $334 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Chicago O'Hare Intl Airport for as low as $222 on momondo.

What cabin class options are available on Chicago O'Hare Intl Airport to Greenville flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl Airport to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to Greenville flights?

You could potentially save up to 3% on your flight if you consider stops on a Chicago O'Hare Intl Airport to Greenville flight.

How have Chicago O'Hare Intl Airport to Greenville flight prices changed over time?

As of October 2026, prices for Chicago O'Hare Intl Airport to Greenville flights are approximately 5% cheaper when compared to flights at the same time last year.

When to book flights from Chicago O'Hare Intl Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Greenville (ORD to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Greenville

Best Price Found

$114

Fastest flight time

1h 56m

Direct flights

Every day

Airports in Greenville

1 airport
The best one-way flight to Greenville from Chicago O'Hare Intl Airport in the past 72 hours is $114. The best round-trip flight deal from Chicago O'Hare Intl Airport to Greenville found on momondo in the last 72 hours is $299.
The fastest flight from Chicago O'Hare Intl Airport to Greenville takes 1h 56m
Direct flights go from Chicago O'Hare Intl Airport to Greenville every day.
There is 1 airport in Greenville. From Chicago O'Hare Intl Airport there are direct flights to Greenville (GSP).
Search flight deals

Frequently asked questions about flying from Chicago O'Hare Intl Airport to Greenville

  • How far is Chicago O'Hare Intl to Greenville by plane?

    Chicago O'Hare Intl and Greenville are 575.0 mi apart from one another. Typically, this will take 1h 56m by plane in normal conditions.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Greenville Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Greenville Airport?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to Greenville?

  • What is the most popular airline from Chicago O'Hare Intl Airport to Greenville?

Best airlines flying from Chicago O'Hare Intl Airport to Greenville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $209Free CancellationRating
7.0
12,210 reviews
Search American Airlines flights
United AirlinesPriceFrom $218Free CancellationRating
7.3
10,451 reviews
Search United Airlines flights

  • United Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    United Airlines flight deals from Chicago O'Hare Intl Airport to Greenville start from $218 round-trip. Over the 12 United Airlines flights for this route in a normal week, average airfare is usually $336 round-trip - but some users have found much cheaper deals with momondo.

  • American Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    The best American Airlines deal for Chicago O'Hare Intl Airport to Greenville flight tickets found on momondo in the last 72 hours was $209, round-trip. It should be noted that an average American Airlines flight deal for this route in this time was higher, at $319 round-trip. American Airlines operates 3 flights out of Chicago O'Hare Intl Airport into Greenville in an average week, so prices vary by time and availability. 12,210 American Airlines reviews by users on momondo have scored the airline at 7.0/10.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Greenwood
Simpsonville
Greer
Duncan
Seneca

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Chicago which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Chicago to Greenville?

momondo provides multiple filters to help you find the best flight to Greenville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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