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Cheap flights from Chicago O'Hare Intl Airport to Greenville from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago O'Hare Intl Airport to Greenville departing on 12/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Chicago O'Hare Intl Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
7:10 am - 10:06 amORD-GSP
1h 56mnonstop
United Airlines Logo
9:10 am - 10:24 amGSP-ORD
2h 14mnonstop
$219United Airlines
Find Deal
Sat, Nov 8 - Wed, Nov 12
Delta Logo
4:20 pm - 11:40 pmORD-GSP
6h 20m1 stop
Delta Logo
7:25 am - 1:50 pmGSP-ORD
7h 25m1 stop
$222Delta
Find Deal
Wed, Dec 10 - Sun, Dec 14
American Airlines Logo
8:00 am - 10:52 amORD-GSP
1h 52mnonstop
American Airlines Logo
6:12 am - 7:30 amGSP-ORD
2h 18mnonstop
$226American Airlines
Find Deal
Sat, Nov 1 - Sat, Nov 15
American Airlines Logo
7:10 am - 12:17 pmORD-GSP
4h 07m1 stop
American Airlines Logo
8:14 pm - 9:30 pmGSP-ORD
2h 16mnonstop
$229American Airlines
Find Deal
Sat, Nov 15 - Sat, Nov 22
American Airlines Logo
8:03 am - 2:03 pmORD-GSP
5h 00m1 stop
American Airlines Logo
7:45 am - 9:05 amGSP-ORD
2h 20mnonstop
$233American Airlines
Find Deal
Thu, Jan 1 - Wed, Jan 7
American Airlines Logo
11:31 am - 7:09 pmORD-GSP
6h 38m1 stop
American Airlines Logo
8:14 pm - 9:30 pmGSP-ORD
2h 16mnonstop
$236American Airlines
Find Deal
Wed, Dec 10 - Sun, Dec 14
Delta Logo
10:46 am - 5:52 pmORD-GSP
6h 06m1 stop
Delta Logo
3:35 pm - 8:38 pmGSP-ORD
6h 03m1 stop
$237Delta
Find Deal
Sat, Nov 22 - Tue, Dec 2
Multiple Airlines Logo
5:15 am - 7:23 pmORD-GSP
13h 08m1 stop
Multiple Airlines Logo
5:17 pm - 12:51 pmGSP-ORD
20h 34m1 stop
$238Multiple Airlines
Find Deal
Mon, Nov 10 - Thu, Nov 13
United Airlines Logo
1:00 pm - 7:10 pmORD-GSP
5h 10m1 stop
United Airlines Logo
9:10 am - 10:24 amGSP-ORD
2h 14mnonstop
$239United Airlines
Find Deal
Sat, Nov 1 - Mon, Nov 3
American Airlines Logo
11:31 am - 7:09 pmORD-GSP
6h 38m1 stop
American Airlines Logo
6:00 am - 7:13 amGSP-ORD
2h 13mnonstop
$240American Airlines
Find Deal
Thu, Dec 11 - Sun, Dec 14

Delta flights from Chicago O'Hare Intl Airport to Greenville

Our best Delta deals on Chicago O'Hare Intl Airport to Greenville flight tickets
Delta
Dec 10
ORD4:20 pmChicago O'Hare Intl
6h 20m
1 stop
GSP11:40 pmGreenville
Dec 14
GSP7:25 amGreenville
7h 25m
1 stop
ORD1:50 pmChicago O'Hare Intl
$222
Find similar
Delta
Nov 22
ORD10:46 amChicago O'Hare Intl
6h 06m
1 stop
GSP5:52 pmGreenville
Dec 2
GSP3:35 pmGreenville
6h 03m
1 stop
ORD8:38 pmChicago O'Hare Intl
$237
Find similar
Delta
Nov 1
ORD6:10 pmChicago O'Hare Intl
4h 45m
1 stop
GSP11:55 pmGreenville
Nov 15
GSP5:16 pmGreenville
6h 14m
1 stop
ORD10:30 pmChicago O'Hare Intl
$246
Find similar

American Airlines flights from Chicago O'Hare Intl Airport to Greenville

Our best American Airlines deals on Chicago O'Hare Intl Airport to Greenville flight tickets
American Airlines
Nov 1
ORD8:00 amChicago O'Hare Intl
1h 52m
GSP10:52 amGreenville
Nov 15
GSP6:12 amGreenville
2h 18m
ORD7:30 amChicago O'Hare Intl
$226
Find similar
American Airlines
Nov 15
ORD7:10 amChicago O'Hare Intl
4h 07m
1 stop
GSP12:17 pmGreenville
Nov 22
GSP8:14 pmGreenville
2h 16m
ORD9:30 pmChicago O'Hare Intl
$229
Find similar
American Airlines
Jan 1
ORD8:03 amChicago O'Hare Intl
5h 00m
1 stop
GSP2:03 pmGreenville
Jan 7
GSP7:45 amGreenville
2h 20m
ORD9:05 amChicago O'Hare Intl
$233
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Chicago O'Hare Intl Airport to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 11/8

7:10 am-10:06 am

Nonstop1h 56m

Greenville

Wed 11/12

9:10 am-10:24 am

Nonstop2h 14m

$219

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 12/10

4:20 pm-11:40 pm

1 stop6h 20m

Greenville

Sun 12/14

7:25 am-1:50 pm

1 stop7h 25m

$222

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 11/1

8:00 am-10:52 am

Nonstop1h 52m

Greenville

Sat 11/15

6:12 am-7:30 am

Nonstop2h 18m

$226

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 11/15

7:10 am-12:17 pm

1 stop4h 07m

Greenville

Sat 11/22

8:14 pm-9:30 pm

Nonstop2h 16m

$229

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 1/1

8:03 am-2:03 pm

1 stop5h 00m

Greenville

Wed 1/7

7:45 am-9:05 am

Nonstop2h 20m

$233

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Wed 12/10

11:31 am-7:09 pm

1 stop6h 38m

Greenville

Sun 12/14

8:14 pm-9:30 pm

Nonstop2h 16m

$236

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 11/22

10:46 am-5:52 pm

1 stop6h 06m

Greenville

Tue 12/2

3:35 pm-8:38 pm

1 stop6h 03m

$237

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Mon 11/10

5:15 am-7:23 pm

1 stop13h 08m

Greenville

Thu 11/13

5:17 pm-12:51 pm

1 stop20h 34m

$238

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Sat 11/1

1:00 pm-7:10 pm

1 stop5h 10m

Greenville

Mon 11/3

9:10 am-10:24 am

Nonstop2h 14m

$239

ChicagoGreenville

ORD - GSP

ORDGSP

Chicago O'Hare Intl

Thu 12/11

11:31 am-7:09 pm

1 stop6h 38m

Greenville

Sun 12/14

6:00 am-7:13 am

Nonstop2h 13m

$240

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Chicago O'Hare Intl Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of June is another great option to travel to Greenville, with average flight prices from Chicago O'Hare Intl Airport averaging around $281.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Chicago O'Hare Intl Airport. The lowest ticket price found for a Saturday departure recently was $292. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $404. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Chicago O'Hare Intl Airport to Greenville during this time can be as low as $307. Flights to Greenville are more costly in the evening, with an average ticket price of $319. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Chicago O'Hare Intl to Greenville flight route?

Fly from Chicago O'Hare Intl to Greenville for the best Chicago O'Hare Intl - Greenville flight prices

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from Chicago O'Hare Intl Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $310 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Chicago O'Hare Intl Airport for as low as $242 on momondo.

What cabin class options are available on Chicago O'Hare Intl to Greenville flights?

There are 4 cabin classes available to choose from on Chicago O'Hare Intl to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago O'Hare Intl Airport to Greenville flights?

You could potentially save up to 17% on your flight if you consider stops on a Chicago O'Hare Intl Airport to Greenville flight.

How have Chicago O'Hare Intl Airport to Greenville flight prices changed over time?

As of October 2025, prices for Chicago O'Hare Intl Airport to Greenville flights are approximately 63% more expensive when compared to flights at the same time last year.

When to book flights from Chicago O'Hare Intl Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago O'Hare Intl Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago O'Hare Intl Airport to Greenville (ORD to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago O'Hare Intl Airport to Greenville

Best Price Found

$168

Fastest flight time

1h 48m

Direct flights

Mon, Tue, Wed, Fri, Sat and Sun

Airports in Greenville

1 airport
The best one-way flight to Greenville from Chicago O'Hare Intl Airport in the past 72 hours is $168. The best round-trip flight deal from Chicago O'Hare Intl Airport to Greenville found on momondo in the last 72 hours is $229.
The fastest flight from Chicago O'Hare Intl Airport to Greenville takes 1h 48m
Direct flights go from Chicago O'Hare Intl Airport to Greenville on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There is 1 airport near Greenville: Greenville (GSP)
Search flight deals

  • How far is Chicago O'Hare Intl to Greenville by plane?

    Chicago O'Hare Intl and Greenville are 575.0 mi apart from one another. Typically, this will take 1h 48m by plane in normal conditions.

  • When did momondo last update prices for flights from Chicago O'Hare Intl Airport to Greenville Airport?

    Prices for flights from Chicago O'Hare Intl Airport to Greenville Airport were last updated today.

  • How many operators does momondo search for flights from Chicago O'Hare Intl Airport to Greenville Airport?

  • How old do you have to be to fly from Chicago O'Hare Intl Airport to Greenville Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Chicago O'Hare Intl Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The necessary travel and health documents for your Greenville Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Chicago O'Hare Intl Airport to Greenville?

  • What is the most popular airline from Chicago O'Hare Intl Airport to Greenville?

Best airlines flying from Chicago O'Hare Intl Airport to Greenville

Compare and see reviews for airlines that fly from Chicago O'Hare Intl Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $148Free CancellationRating
7.9
7,978 reviews
Search Delta flights
American AirlinesPriceFrom $202Free CancellationRating
7.2
11,024 reviews
Search American Airlines flights
United AirlinesPriceFrom $228Free CancellationRating
7.4
8,991 reviews
Search United Airlines flights

  • United Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    United Airlines flight deals from Chicago O'Hare Intl Airport to Greenville start from $228 round-trip. Over the 27 United Airlines flights for this route in a normal week, average airfare is usually $371 round-trip - but some users have found much cheaper deals with momondo.

  • American Airlines Flights From Chicago O'Hare Intl Airport to Greenville

    The best American Airlines deal for Chicago O'Hare Intl Airport to Greenville flight tickets found on momondo in the last 72 hours was $202, round-trip. It should be noted that an average American Airlines flight deal for this route in this time was higher, at $288 round-trip. American Airlines operates 21 flights out of Chicago O'Hare Intl Airport into Greenville in an average week, so prices vary by time and availability. 11,024 American Airlines reviews by users on momondo have scored the airline at 7.2/10.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Chicago which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Chicago to Greenville?

momondo provides multiple filters to help you find the best flight to Greenville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Chicago to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your Greenville trip

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