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Cheap flights from New Orleans to Knoxville from $95

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from New Orleans to Knoxville departing on 5/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from New Orleans to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:10 am - 9:48 pm
MSY
-
TYS
10h 38m
1 stop
Multiple Airlines Logo
9:00 am - 6:55 pm
TYS
-
MSY
10h 55m
1 stop
$226Multiple Airlines
Fri, Apr 17 - Sat, Apr 18
Multiple Airlines Logo
5:06 pm - 1:09 pm
MSY
-
TYS
19h 03m
1 stop
Multiple Airlines Logo
1:15 pm - 6:06 pm
TYS
-
MSY
5h 51m
1 stop
$231Multiple Airlines
Fri, Apr 17 - Mon, Apr 20
Multiple Airlines Logo
5:53 pm - 5:49 pm
MSY
-
TYS
22h 56m
1 stop
Multiple Airlines Logo
4:45 pm - 1:00 pm
TYS
-
MSY
21h 15m
1 stop
$240Multiple Airlines
Thu, Jun 4 - Tue, Jun 9
Multiple Airlines Logo
6:00 am - 8:51 pm
MSY
-
TYS
13h 51m
1 stop
Multiple Airlines Logo
8:30 am - 11:29 am
TYS
-
MSY
27h 59m
1 stop
$244Multiple Airlines
Sat, Mar 28 - Wed, Apr 1
Multiple Airlines Logo
3:30 pm - 8:40 pm
MSY
-
TYS
28h 10m
1 stop
Multiple Airlines Logo
9:00 am - 6:55 pm
TYS
-
MSY
10h 55m
1 stop
$250Multiple Airlines
Sat, Apr 11 - Sat, Apr 18
Multiple Airlines Logo
8:01 pm - 8:08 am
MSY
-
TYS
35h 07m
2 stops
Multiple Airlines Logo
8:30 am - 11:29 am
TYS
-
MSY
27h 59m
1 stop
$252Multiple Airlines
Sat, Mar 28 - Wed, Apr 1
Multiple Airlines Logo
7:10 pm - 10:36 am
MSY
-
TYS
14h 26m
1 stop
Multiple Airlines Logo
8:00 am - 10:44 pm
TYS
-
MSY
15h 44m
1 stop
$259Multiple Airlines
Tue, Mar 31 - Sat, Apr 4
Multiple Airlines Logo
6:32 pm - 5:30 pm
MSY
-
TYS
21h 58m
2 stops
Multiple Airlines Logo
9:32 pm - 9:15 am
TYS
-
MSY
12h 43m
1 stop
$266Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Multiple Airlines Logo
7:18 pm - 11:39 pm
MSY
-
TYS
27h 21m
1 stop
Multiple Airlines Logo
9:25 pm - 4:31 pm
TYS
-
MSY
20h 06m
1 stop
$267Multiple Airlines
Wed, Apr 1 - Sun, Apr 5
Multiple Airlines Logo
5:06 pm - 2:09 pm
MSY
-
TYS
20h 03m
1 stop
Multiple Airlines Logo
9:12 pm - 3:48 pm
TYS
-
MSY
19h 36m
1 stop
$270Multiple Airlines
Fri, Apr 3 - Sun, Apr 12

Southwest flights from New Orleans to Knoxville

Our best Southwest deals on New Orleans to Knoxville flight tickets
Southwest
Apr 1
MSY12:35 pmNew Orleans Louis Armstrong
6h 30m
2 stops
TYS8:05 pmKnoxville McGhee Tyson
Apr 5
TYS6:35 amKnoxville McGhee Tyson
8h 45m
2 stops
MSY2:20 pmNew Orleans Louis Armstrong
$427
Southwest
Apr 1
MSY12:35 pmNew Orleans Louis Armstrong
6h 30m
2 stops
TYS8:05 pmKnoxville McGhee Tyson
Apr 5
TYS6:35 amKnoxville McGhee Tyson
8h 35m
2 stops
MSY2:10 pmNew Orleans Louis Armstrong
$447

momondo Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 18, 2026.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 4/17

10:10 am-9:48 pm

1 stop10h 38m

Knoxville McGhee Tyson

Sat 4/18

9:00 am-6:55 pm

1 stop10h 55m

$226

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 4/17

5:06 pm-1:09 pm

1 stop19h 03m

Knoxville McGhee Tyson

Mon 4/20

1:15 pm-6:06 pm

1 stop5h 51m

$231

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 6/4

5:53 pm-5:49 pm

1 stop22h 56m

Knoxville McGhee Tyson

Tue 6/9

4:45 pm-1:00 pm

1 stop21h 15m

$240

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 3/28

6:00 am-8:51 pm

1 stop13h 51m

Knoxville McGhee Tyson

Wed 4/1

8:30 am-11:29 am

1 stop27h 59m

$244

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 4/11

3:30 pm-8:40 pm

1 stop28h 10m

Knoxville McGhee Tyson

Sat 4/18

9:00 am-6:55 pm

1 stop10h 55m

$250

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 3/28

8:01 pm-8:08 am

2 stops35h 07m

Knoxville McGhee Tyson

Wed 4/1

8:30 am-11:29 am

1 stop27h 59m

$252

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 3/31

7:10 pm-10:36 am

1 stop14h 26m

Knoxville McGhee Tyson

Sat 4/4

8:00 am-10:44 pm

1 stop15h 44m

$259

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 4/23

6:32 pm-5:30 pm

2 stops21h 58m

Knoxville McGhee Tyson

Sun 4/26

9:32 pm-9:15 am

1 stop12h 43m

$266

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 4/1

7:18 pm-11:39 pm

1 stop27h 21m

Knoxville McGhee Tyson

Sun 4/5

9:25 pm-4:31 pm

1 stop20h 06m

$267

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 4/3

5:06 pm-2:09 pm

1 stop20h 03m

Knoxville McGhee Tyson

Sun 4/12

9:12 pm-3:48 pm

1 stop19h 36m

$270

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from New Orleans to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from New Orleans, with most prices found around $263. If you aren’t able to travel during the month of July, then book flights to Knoxville from New Orleans during September instead. Flights to Knoxville in September, while not as cheap as those in July, still average around $281.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from New Orleans when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $377 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from New Orleans for as low as $268 on momondo.

How have New Orleans to Knoxville flight prices changed over time?

As of March 2026, prices for New Orleans to Knoxville flights are approximately 15% more expensive when compared to flights at the same time last year.

When to book flights from New Orleans to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from New Orleans to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap New Orleans to Knoxville (MSY to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from New Orleans to Knoxville

Fastest flight time

7h 15m

Direct flights

None
The fastest flight from New Orleans to Knoxville takes 7h 15m
There are no direct flights from New Orleans to Knoxville. There are no popular flight routes from New Orleans to Knoxville.
Search flight deals

  • How far is New Orleans Louis Armstrong to Knoxville McGhee Tyson by plane?

    The straight-line distance from New Orleans Louis Armstrong to Knoxville McGhee Tyson is 546.5 mi. By plane, this route typically takes 7h 15m.

  • When did momondo last update prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from New Orleans to Knoxville?

Best airlines flying from New Orleans to Knoxville

Compare and see reviews for airlines that fly from New Orleans to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $224Free CancellationRating
7.1
11,473 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,293 reviews
Search Delta flights
SouthwestPriceFrom $336Free CancellationRating
8.0
4,319 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from New Orleans to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from New Orleans to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from New Orleans to Knoxville with flexible booking policies on momondo?

Flights from New Orleans to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from New Orleans to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from New Orleans.

I’m not ready to book a flight from New Orleans to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from New Orleans to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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