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Cheap flights from New Orleans to Knoxville from $95

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from New Orleans to Knoxville departing on 1/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from New Orleans to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:11 pm - 11:05 pm
MSY
-
TYS
4h 54m1 stop
Multiple Airlines Logo
9:29 am - 8:21 am
TYS
-
MSY
23h 52m1 stop
$208Multiple Airlines
Thu, Jan 29 - Sun, Feb 1
Multiple Airlines Logo
6:20 am - 4:59 pm
MSY
-
TYS
9h 39m1 stop
Multiple Airlines Logo
3:50 pm - 8:55 pm
TYS
-
MSY
6h 05m1 stop
$211Multiple Airlines
Mon, Feb 23 - Wed, Feb 25
American Airlines Logo
6:45 pm - 11:54 pm
MSY
-
TYS
4h 09m1 stop
American Airlines Logo
5:35 am - 9:51 am
TYS
-
MSY
5h 16m1 stop
$235American Airlines
Sat, Feb 14 - Wed, Feb 18
Multiple Airlines Logo
3:01 pm - 9:37 pm
MSY
-
TYS
5h 36m1 stop
Multiple Airlines Logo
8:30 am - 8:21 am
TYS
-
MSY
24h 51m1 stop
$261Multiple Airlines
Mon, Jan 5 - Mon, Jan 19
Multiple Airlines Logo
7:42 pm - 5:28 pm
MSY
-
TYS
20h 46m2 stops
Multiple Airlines Logo
9:29 am - 9:29 pm
TYS
-
MSY
13h 00m1 stop
$262Multiple Airlines
Thu, Jan 29 - Sun, Feb 1
Multiple Airlines Logo
3:01 pm - 9:37 pm
MSY
-
TYS
5h 36m1 stop
Multiple Airlines Logo
8:30 am - 9:29 pm
TYS
-
MSY
13h 59m1 stop
$270Multiple Airlines
Mon, Jan 5 - Mon, Jan 19
Multiple Airlines Logo
3:10 pm - 8:18 am
MSY
-
TYS
16h 08m1 stop
Multiple Airlines Logo
5:56 pm - 4:10 pm
TYS
-
MSY
23h 14m2 stops
$274Multiple Airlines
Fri, Jan 2 - Mon, Jan 5
Multiple Airlines Logo
6:20 am - 4:59 pm
MSY
-
TYS
9h 39m1 stop
Multiple Airlines Logo
3:50 pm - 9:38 am
TYS
-
MSY
18h 48m2 stops
$275Multiple Airlines
Mon, Feb 23 - Wed, Feb 25
Delta Logo
11:50 am - 5:16 pm
MSY
-
TYS
4h 26m1 stop
Delta Logo
6:10 pm - 11:30 pm
TYS
-
MSY
6h 20m1 stop
$277Delta
Tue, Jan 6 - Wed, Jan 7
Multiple Airlines Logo
3:01 pm - 9:37 pm
MSY
-
TYS
5h 36m1 stop
Multiple Airlines Logo
12:55 pm - 9:29 pm
TYS
-
MSY
33h 34m2 stops
$281Multiple Airlines
Mon, Jan 5 - Mon, Jan 19

American Airlines flights from New Orleans to Knoxville

Our best American Airlines deals on New Orleans to Knoxville flight tickets
American Airlines
Feb 14
MSY6:45 pmNew Orleans Louis Armstrong
4h 09m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
Feb 18
TYS5:35 amKnoxville McGhee Tyson
5h 16m
1 stop
MSY9:51 amNew Orleans Louis Armstrong
$235
Find similar
American Airlines
Jan 17
MSY8:48 amNew Orleans Louis Armstrong
6h 08m
1 stop
TYS3:56 pmKnoxville McGhee Tyson
Jan 19
TYS6:51 pmKnoxville McGhee Tyson
5h 08m
1 stop
MSY10:59 pmNew Orleans Louis Armstrong
$286
Find similar
American Airlines
Dec 31
MSY12:48 pmNew Orleans Louis Armstrong
4h 12m
1 stop
TYS6:00 pmKnoxville McGhee Tyson
Jan 4
TYS4:28 pmKnoxville McGhee Tyson
7h 06m
1 stop
MSY10:34 pmNew Orleans Louis Armstrong
$372
Find similar

United Airlines flights from New Orleans to Knoxville

Our best United Airlines deals on New Orleans to Knoxville flight tickets
United Airlines
Jan 8
MSY7:00 amNew Orleans Louis Armstrong
5h 50m
1 stop
TYS1:50 pmKnoxville McGhee Tyson
Jan 11
TYS2:25 pmKnoxville McGhee Tyson
6h 20m
1 stop
MSY7:45 pmNew Orleans Louis Armstrong
$407
Find similar
United Airlines
Feb 15
MSY5:34 pmNew Orleans Louis Armstrong
5h 10m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
Feb 21
TYS6:45 amKnoxville McGhee Tyson
7h 27m
1 stop
MSY1:12 pmNew Orleans Louis Armstrong
$457
Find similar
United Airlines
Dec 31
MSY2:14 pmNew Orleans Louis Armstrong
31h 25m
2 stops
TYS10:39 pmKnoxville McGhee Tyson
Jan 4
TYS5:45 amKnoxville McGhee Tyson
6h 30m
1 stop
MSY11:15 amNew Orleans Louis Armstrong
$461
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 11, 2025.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 1/29

5:11 pm-11:05 pm

1 stop4h 54m

Knoxville McGhee Tyson

Sun 2/1

9:29 am-8:21 am

1 stop23h 52m

$208

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 2/23

6:20 am-4:59 pm

1 stop9h 39m

Knoxville McGhee Tyson

Wed 2/25

3:50 pm-8:55 pm

1 stop6h 05m

$211

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 2/14

6:45 pm-11:54 pm

1 stop4h 09m

Knoxville McGhee Tyson

Wed 2/18

5:35 am-9:51 am

1 stop5h 16m

$235

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 1/5

3:01 pm-9:37 pm

1 stop5h 36m

Knoxville McGhee Tyson

Mon 1/19

8:30 am-8:21 am

1 stop24h 51m

$261

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 1/29

7:42 pm-5:28 pm

2 stops20h 46m

Knoxville McGhee Tyson

Sun 2/1

9:29 am-9:29 pm

1 stop13h 00m

$262

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 1/5

3:01 pm-9:37 pm

1 stop5h 36m

Knoxville McGhee Tyson

Mon 1/19

8:30 am-9:29 pm

1 stop13h 59m

$270

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 1/2

3:10 pm-8:18 am

1 stop16h 08m

Knoxville McGhee Tyson

Mon 1/5

5:56 pm-4:10 pm

2 stops23h 14m

$274

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 2/23

6:20 am-4:59 pm

1 stop9h 39m

Knoxville McGhee Tyson

Wed 2/25

3:50 pm-9:38 am

2 stops18h 48m

$275

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 1/6

11:50 am-5:16 pm

1 stop4h 26m

Knoxville McGhee Tyson

Wed 1/7

6:10 pm-11:30 pm

1 stop6h 20m

$277

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 1/5

3:01 pm-9:37 pm

1 stop5h 36m

Knoxville McGhee Tyson

Mon 1/19

12:55 pm-9:29 pm

2 stops33h 34m

$281

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from New Orleans to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between New Orleans and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from New Orleans, with most prices found around $263. If you aren’t able to travel during the month of July, then book flights to Knoxville from New Orleans during January instead. Flights to Knoxville in January, while not as cheap as those in July, still average around $278.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from New Orleans to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $314. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from New Orleans to Knoxville for around $403.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from New Orleans to Knoxville when you can find flight prices for as low as $321. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $365.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from New Orleans when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from New Orleans for as low as $252 on momondo.

How have New Orleans to Knoxville flight prices changed over time?

As of December 2025, prices for New Orleans to Knoxville flights are approximately 70% more expensive when compared to flights at the same time last year.

When to book flights from New Orleans to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from New Orleans to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap New Orleans to Knoxville (MSY to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from New Orleans to Knoxville

Fastest flight time

3h 36m

Direct flights

None
The fastest flight from New Orleans to Knoxville takes 3h 36m
There are no direct flights from New Orleans to Knoxville. There are no popular flight routes from New Orleans to Knoxville.
Search flight deals

  • How far is New Orleans Louis Armstrong to Knoxville McGhee Tyson by plane?

    The straight-line distance from New Orleans Louis Armstrong to Knoxville McGhee Tyson is 546.5 mi. By plane, this route typically takes 3h 36m.

  • When did momondo last update prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from New Orleans to Knoxville?

Best airlines flying from New Orleans to Knoxville

Compare and see reviews for airlines that fly from New Orleans to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $198Free CancellationRating
7.4
9,095 reviews
Search United Airlines flights
American AirlinesPriceFrom $228Free CancellationRating
7.2
11,050 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,008 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from New Orleans to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from New Orleans to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from New Orleans to Knoxville with flexible booking policies on momondo?

Flights from New Orleans to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from New Orleans to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from New Orleans.

I’m not ready to book a flight from New Orleans to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from New Orleans to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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