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Cheap flights from New Orleans to Knoxville from $146

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from New Orleans to Knoxville departing on 2/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from New Orleans to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:10 am - 10:34 am
MSY
-
TYS
27h 24m
1 stop
Multiple Airlines Logo
3:50 pm - 8:21 am
TYS
-
MSY
17h 31m
1 stop
$239Multiple Airlines
Sun, Feb 22 - Wed, Feb 25
Multiple Airlines Logo
3:43 pm - 10:25 pm
MSY
-
TYS
29h 42m
2 stops
Multiple Airlines Logo
9:44 pm - 3:00 pm
TYS
-
MSY
18h 16m
1 stop
$265Multiple Airlines
Wed, Feb 11 - Sun, Feb 15
Multiple Airlines Logo
8:36 pm - 10:06 am
MSY
-
TYS
36h 30m
2 stops
Multiple Airlines Logo
9:42 pm - 8:55 pm
TYS
-
MSY
24h 13m
1 stop
$268Multiple Airlines
Mon, Feb 23 - Thu, Mar 5
Multiple Airlines Logo
8:57 pm - 8:42 pm
MSY
-
TYS
22h 45m
1 stop
Multiple Airlines Logo
9:44 pm - 3:00 pm
TYS
-
MSY
18h 16m
1 stop
$269Multiple Airlines
Wed, Feb 11 - Sun, Feb 15
Multiple Airlines Logo
8:01 pm - 12:24 pm
MSY
-
TYS
15h 23m
1 stop
Multiple Airlines Logo
9:00 am - 6:55 pm
TYS
-
MSY
10h 55m
1 stop
$283Multiple Airlines
Sat, Apr 11 - Sat, Apr 18
Frontier Logo
3:13 pm - 7:27 pm
MSY
-
TYS
27h 14m
1 stop
Frontier Logo
8:13 pm - 12:24 am
TYS
-
MSY
29h 11m
1 stop
$287Frontier
Thu, Feb 12 - Mon, Feb 16
Multiple Airlines Logo
8:15 am - 10:25 pm
MSY
-
TYS
13h 10m
2 stops
Multiple Airlines Logo
7:40 am - 9:00 pm
TYS
-
MSY
14h 20m
1 stop
$291Multiple Airlines
Thu, Feb 12 - Mon, Feb 16
Multiple Airlines Logo
10:59 pm - 10:05 pm
MSY
-
TYS
22h 06m
2 stops
Multiple Airlines Logo
3:50 pm - 8:55 pm
TYS
-
MSY
6h 05m
1 stop
$293Multiple Airlines
Sun, Feb 22 - Wed, Feb 25
Multiple Airlines Logo
8:00 am - 6:32 pm
MSY
-
TYS
9h 32m
1 stop
Multiple Airlines Logo
9:42 pm - 8:55 pm
TYS
-
MSY
24h 13m
1 stop
$297Multiple Airlines
Mon, Feb 23 - Thu, Mar 5
Multiple Airlines Logo
11:06 am - 5:30 pm
MSY
-
TYS
5h 24m
1 stop
Multiple Airlines Logo
9:32 pm - 9:15 am
TYS
-
MSY
12h 43m
1 stop
$306Multiple Airlines
Fri, Apr 24 - Sun, Apr 26

Delta flights from New Orleans to Knoxville

Our best Delta deals on New Orleans to Knoxville flight tickets
Delta
Mar 19
MSY1:17 pmNew Orleans Louis Armstrong
3h 28m
1 stop
TYS5:45 pmKnoxville McGhee Tyson
Mar 23
TYS5:10 pmKnoxville McGhee Tyson
5h 46m
1 stop
MSY9:56 pmNew Orleans Louis Armstrong
$317
Delta
Jun 18
MSY11:25 amNew Orleans Louis Armstrong
5h 50m
1 stop
TYS6:15 pmKnoxville McGhee Tyson
Jun 30
TYS5:57 pmKnoxville McGhee Tyson
6h 26m
1 stop
MSY11:23 pmNew Orleans Louis Armstrong
$337
Delta
Feb 16
MSY7:37 amNew Orleans Louis Armstrong
5h 14m
1 stop
TYS1:51 pmKnoxville McGhee Tyson
Feb 20
TYS6:41 pmKnoxville McGhee Tyson
5h 33m
1 stop
MSY11:14 pmNew Orleans Louis Armstrong
$714

American Airlines flights from New Orleans to Knoxville

Our best American Airlines deals on New Orleans to Knoxville flight tickets
American Airlines
Mar 21
MSY5:30 amNew Orleans Louis Armstrong
5h 00m
1 stop
TYS11:30 amKnoxville McGhee Tyson
Mar 26
TYS5:00 amKnoxville McGhee Tyson
4h 27m
1 stop
MSY8:27 amNew Orleans Louis Armstrong
$373
American Airlines
Feb 12
MSY9:17 amNew Orleans Louis Armstrong
6h 59m
1 stop
TYS5:16 pmKnoxville McGhee Tyson
Feb 16
TYS6:21 pmKnoxville McGhee Tyson
5h 30m
1 stop
MSY10:51 pmNew Orleans Louis Armstrong
$378

momondo Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sun 2/22

6:10 am-10:34 am

1 stop27h 24m

Knoxville McGhee Tyson

Wed 2/25

3:50 pm-8:21 am

1 stop17h 31m

$239

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 2/11

3:43 pm-10:25 pm

2 stops29h 42m

Knoxville McGhee Tyson

Sun 2/15

9:44 pm-3:00 pm

1 stop18h 16m

$265

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 2/23

8:36 pm-10:06 am

2 stops36h 30m

Knoxville McGhee Tyson

Thu 3/5

9:42 pm-8:55 pm

1 stop24h 13m

$268

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 2/11

8:57 pm-8:42 pm

1 stop22h 45m

Knoxville McGhee Tyson

Sun 2/15

9:44 pm-3:00 pm

1 stop18h 16m

$269

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 4/11

8:01 pm-12:24 pm

1 stop15h 23m

Knoxville McGhee Tyson

Sat 4/18

9:00 am-6:55 pm

1 stop10h 55m

$283

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 2/12

3:13 pm-7:27 pm

1 stop27h 14m

Knoxville McGhee Tyson

Mon 2/16

8:13 pm-12:24 am

1 stop29h 11m

$287

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 2/12

8:15 am-10:25 pm

2 stops13h 10m

Knoxville McGhee Tyson

Mon 2/16

7:40 am-9:00 pm

1 stop14h 20m

$291

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sun 2/22

10:59 pm-10:05 pm

2 stops22h 06m

Knoxville McGhee Tyson

Wed 2/25

3:50 pm-8:55 pm

1 stop6h 05m

$293

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 2/23

8:00 am-6:32 pm

1 stop9h 32m

Knoxville McGhee Tyson

Thu 3/5

9:42 pm-8:55 pm

1 stop24h 13m

$297

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 4/24

11:06 am-5:30 pm

1 stop5h 24m

Knoxville McGhee Tyson

Sun 4/26

9:32 pm-9:15 am

1 stop12h 43m

$306

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from New Orleans to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from New Orleans, with most prices found around $263. If you aren’t able to travel during the month of July, then book flights to Knoxville from New Orleans during September instead. Flights to Knoxville in September, while not as cheap as those in July, still average around $278.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from New Orleans when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $336 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from New Orleans for as low as $252 on momondo.

How have New Orleans to Knoxville flight prices changed over time?

As of January 2026, prices for New Orleans to Knoxville flights are approximately 35% cheaper when compared to flights at the same time last year.

When to book flights from New Orleans to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from New Orleans to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap New Orleans to Knoxville (MSY to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from New Orleans to Knoxville

Fastest flight time

3h 28m

Direct flights

None
The fastest flight from New Orleans to Knoxville takes 3h 28m
There are no direct flights from New Orleans to Knoxville. There are no popular flight routes from New Orleans to Knoxville.
Search flight deals

  • How far is New Orleans Louis Armstrong to Knoxville McGhee Tyson by plane?

    The straight-line distance from New Orleans Louis Armstrong to Knoxville McGhee Tyson is 546.5 mi. By plane, this route typically takes 3h 28m.

  • When did momondo last update prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from New Orleans to Knoxville?

Best airlines flying from New Orleans to Knoxville

Compare and see reviews for airlines that fly from New Orleans to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $198Free CancellationRating
7.4
9,214 reviews
Search United Airlines flights
American AirlinesPriceFrom $224Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,127 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Murphy
Alcoa
Maryville
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from New Orleans to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from New Orleans to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from New Orleans to Knoxville with flexible booking policies on momondo?

Flights from New Orleans to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from New Orleans to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from New Orleans.

I’m not ready to book a flight from New Orleans to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from New Orleans to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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