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Cheap flights from New Orleans to Knoxville from $120

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from New Orleans to Knoxville departing on 8/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from New Orleans to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:00 am - 7:05 pm
MSY
-
TYS
10h 05m
1 stop
Multiple Airlines Logo
2:49 pm - 5:32 pm
TYS
-
MSY
27h 43m
1 stop
$273Multiple Airlines
Fri, Aug 28 - Mon, Aug 31
Multiple Airlines Logo
8:00 am - 7:05 pm
MSY
-
TYS
10h 05m
1 stop
Multiple Airlines Logo
2:49 pm - 5:32 pm
TYS
-
MSY
27h 43m
1 stop
$275Multiple Airlines
Fri, Aug 28 - Mon, Aug 31
American Airlines Logo
6:01 pm - 11:51 pm
MSY
-
TYS
4h 50m
1 stop
American Airlines Logo
5:37 am - 11:30 am
TYS
-
MSY
6h 53m
1 stop
$277American Airlines
Sat, Jul 18 - Wed, Jul 22
Multiple Airlines Logo
8:00 am - 7:05 pm
MSY
-
TYS
10h 05m
1 stop
Multiple Airlines Logo
2:49 pm - 5:32 pm
TYS
-
MSY
27h 43m
1 stop
$281Multiple Airlines
Fri, Aug 28 - Mon, Aug 31
Southwest Logo
7:10 am - 12:55 pm
MSY
-
TYS
4h 45m
1 stop
Southwest Logo
7:10 am - 3:15 pm
TYS
-
MSY
9h 05m
2 stops
$282Southwest
Sat, Jul 18 - Wed, Jul 22
Southwest Logo
10:10 am - 7:50 pm
MSY
-
TYS
8h 40m
2 stops
Southwest Logo
5:30 pm - 10:40 pm
TYS
-
MSY
6h 10m
2 stops
$287Southwest
Tue, Sep 29 - Tue, Oct 6
Multiple Airlines Logo
8:00 am - 7:05 pm
MSY
-
TYS
10h 05m
1 stop
Multiple Airlines Logo
1:25 pm - 4:26 pm
TYS
-
MSY
28h 01m
2 stops
$289Multiple Airlines
Fri, Aug 28 - Mon, Aug 31
American Airlines Logo
9:00 am - 4:42 pm
MSY
-
TYS
6h 42m
1 stop
American Airlines Logo
8:37 pm - 12:10 am
TYS
-
MSY
4h 33m
1 stop
$290American Airlines
Tue, Sep 29 - Mon, Oct 5
Multiple Airlines Logo
8:00 am - 11:33 pm
MSY
-
TYS
14h 33m
1 stop
Multiple Airlines Logo
12:40 pm - 4:27 pm
TYS
-
MSY
28h 47m
2 stops
$291Multiple Airlines
Fri, Jul 10 - Fri, Jul 17
Southwest Logo
7:10 am - 2:20 pm
MSY
-
TYS
6h 10m
2 stops
Southwest Logo
7:20 pm - 12:05 am
TYS
-
MSY
5h 45m
1 stop
$295Southwest
Tue, Sep 29 - Mon, Oct 5

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American Airlines flights from New Orleans to Knoxville

Our best American Airlines deals on New Orleans to Knoxville flight tickets
American Airlines
Jul 18
MSY6:01 pmNew Orleans Louis Armstrong
4h 50m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Jul 22
TYS5:37 amKnoxville McGhee Tyson
6h 53m
1 stop
MSY11:30 amNew Orleans Louis Armstrong
$277
American Airlines
Jul 16
MSY6:01 pmNew Orleans Louis Armstrong
4h 50m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Jul 23
TYS5:31 pmKnoxville McGhee Tyson
7h 27m
1 stop
MSY11:58 pmNew Orleans Louis Armstrong
$377
American Airlines
Jul 5
MSY5:50 amNew Orleans Louis Armstrong
6h 06m
1 stop
TYS12:56 pmKnoxville McGhee Tyson
Jul 19
TYS5:00 amKnoxville McGhee Tyson
4h 38m
1 stop
MSY8:38 amNew Orleans Louis Armstrong
$397

Southwest flights from New Orleans to Knoxville

Our best Southwest deals on New Orleans to Knoxville flight tickets
Southwest
Jul 18
MSY7:10 amNew Orleans Louis Armstrong
4h 45m
1 stop
TYS12:55 pmKnoxville McGhee Tyson
Jul 22
TYS7:10 amKnoxville McGhee Tyson
9h 05m
2 stops
MSY3:15 pmNew Orleans Louis Armstrong
$282
Southwest
Sep 8
MSY6:30 amNew Orleans Louis Armstrong
5h 35m
1 stop
TYS1:05 pmKnoxville McGhee Tyson
Sep 11
TYS2:05 pmKnoxville McGhee Tyson
7h 05m
2 stops
MSY8:10 pmNew Orleans Louis Armstrong
$322
Southwest
Aug 28
MSY9:15 amNew Orleans Louis Armstrong
8h 20m
2 stops
TYS6:35 pmKnoxville McGhee Tyson
Aug 31
TYS2:05 pmKnoxville McGhee Tyson
7h 05m
2 stops
MSY8:10 pmNew Orleans Louis Armstrong
$340

momondo Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 23, 2026.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 8/28

8:00 am-7:05 pm

1 stop10h 05m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-5:32 pm

1 stop27h 43m

$273

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 8/28

8:00 am-7:05 pm

1 stop10h 05m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-5:32 pm

1 stop27h 43m

$275

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 7/18

6:01 pm-11:51 pm

1 stop4h 50m

Knoxville McGhee Tyson

Wed 7/22

5:37 am-11:30 am

1 stop6h 53m

$277

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 8/28

8:00 am-7:05 pm

1 stop10h 05m

Knoxville McGhee Tyson

Mon 8/31

2:49 pm-5:32 pm

1 stop27h 43m

$281

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 7/18

7:10 am-12:55 pm

1 stop4h 45m

Knoxville McGhee Tyson

Wed 7/22

7:10 am-3:15 pm

2 stops9h 05m

$282

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 9/29

10:10 am-7:50 pm

2 stops8h 40m

Knoxville McGhee Tyson

Tue 10/6

5:30 pm-10:40 pm

2 stops6h 10m

$287

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 8/28

8:00 am-7:05 pm

1 stop10h 05m

Knoxville McGhee Tyson

Mon 8/31

1:25 pm-4:26 pm

2 stops28h 01m

$289
Quickest round-trip

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 9/29

9:00 am-4:42 pm

1 stop6h 42m

Knoxville McGhee Tyson

Mon 10/5

8:37 pm-12:10 am

1 stop4h 33m

$290

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 7/10

8:00 am-11:33 pm

1 stop14h 33m

Knoxville McGhee Tyson

Fri 7/17

12:40 pm-4:27 pm

2 stops28h 47m

$291

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 9/29

7:10 am-2:20 pm

2 stops6h 10m

Knoxville McGhee Tyson

Mon 10/5

7:20 pm-12:05 am

1 stop5h 45m

$295

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from New Orleans to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between New Orleans and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from New Orleans, with most prices found around $283. If you aren’t able to travel during the month of September, then book flights to Knoxville from New Orleans during August instead. Flights to Knoxville in August, while not as cheap as those in September, still average around $356.

How far in advance should I book a flight from New Orleans to Knoxville?

You are more likely to see cheaper flights to Knoxville from New Orleans when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $422 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from New Orleans for as low as $269 on momondo.

How have New Orleans to Knoxville flight prices changed over time?

As of June 2026, prices for New Orleans to Knoxville flights are approximately 22% cheaper when compared to flights at the same time last year.

When to book flights from New Orleans to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from New Orleans to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap New Orleans to Knoxville (MSY to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from New Orleans to Knoxville

Fastest flight time

2h 00m

Direct flights

Sat

Airports in Knoxville

1 airport
The fastest flight from New Orleans to Knoxville takes 2h 00m
Direct flights go from New Orleans to Knoxville on Saturday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From New Orleans there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from New Orleans to Knoxville

  • How far is New Orleans Louis Armstrong to Knoxville McGhee Tyson by plane?

    The straight-line distance from New Orleans Louis Armstrong to Knoxville McGhee Tyson is 546.5 mi. By plane, this route typically takes 2h 00m.

  • When did momondo last update prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from New Orleans to Knoxville?

Best airlines flying from New Orleans to Knoxville

Compare and see reviews for airlines that fly from New Orleans to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,746 reviews
Search American Airlines flights
DeltaPriceFrom $259Free CancellationRating
7.8
8,424 reviews
Search Delta flights
SouthwestPriceFrom $294Free CancellationRating
7.9
4,242 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from New Orleans to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from New Orleans to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from New Orleans to Knoxville with flexible booking policies on momondo?

Flights from New Orleans to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from New Orleans to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from New Orleans.

I’m not ready to book a flight from New Orleans to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from New Orleans to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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