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Cheap flights from New Orleans to Knoxville from $102

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from New Orleans to Knoxville departing on 9/9. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from New Orleans to Knoxville

Cheap round-trip flights

Logo
9:12 am - 5:06 pmMSY-TYS
6h 54m1 stop
Logo
7:20 am - 4:04 pmTYS-MSY
9h 44m1 stop
$199
Find Deal
Fri, Oct 3 - Sun, Oct 5
Logo
7:20 pm - 6:44 pmMSY-TYS
22h 24m1 stop
Logo
5:55 pm - 11:52 pmTYS-MSY
6h 57m1 stop
$210
Find Deal
Thu, Sep 18 - Thu, Sep 25
Logo
4:50 pm - 5:06 pmMSY-TYS
23h 16m1 stop
Logo
9:15 pm - 6:50 pmTYS-MSY
22h 35m1 stop
$215
Find Deal
Thu, Oct 2 - Thu, Oct 9
Logo
9:10 am - 5:05 pmMSY-TYS
6h 55m1 stop
Logo
5:55 pm - 8:07 amTYS-MSY
15h 12m1 stop
$216
Find Deal
Thu, Sep 25 - Sun, Sep 28
American Airlines Logo
7:00 am - 1:12 pmMSY-TYS
5h 12m1 stop
American Airlines Logo
5:05 am - 8:37 amTYS-MSY
4h 32m1 stop
$224American Airlines
Find Deal
Sat, Sep 6 - Thu, Sep 11
American Airlines Logo
6:48 pm - 12:07 amMSY-TYS
4h 19m1 stop
American Airlines Logo
8:36 pm - 12:15 amTYS-MSY
4h 39m1 stop
$249American Airlines
Find Deal
Thu, Sep 25 - Sun, Sep 28
Delta Logo
5:25 am - 10:27 amMSY-TYS
4h 02m1 stop
Delta Logo
5:45 am - 8:00 amTYS-MSY
3h 15m1 stop
$254Delta
Find Deal
Sat, Sep 6 - Thu, Sep 11
American Airlines Logo
5:18 pm - 11:50 pmMSY-TYS
5h 32m1 stop
American Airlines Logo
5:05 am - 11:25 amTYS-MSY
7h 20m1 stop
$259American Airlines
Find Deal
Fri, Sep 5 - Mon, Sep 8
American Airlines Logo
6:48 pm - 12:07 amMSY-TYS
4h 19m1 stop
American Airlines Logo
8:31 pm - 12:15 amTYS-MSY
4h 44m1 stop
$279American Airlines
Find Deal
Thu, Oct 2 - Sun, Oct 5
Delta Logo
10:45 am - 3:05 pmMSY-TYS
3h 20m1 stop
Delta Logo
6:36 pm - 11:34 pmTYS-MSY
5h 58m1 stop
$308Delta
Find Deal
Sat, Dec 13 - Sat, Dec 20

Delta flights from New Orleans to Knoxville

Our best Delta deals on New Orleans to Knoxville flight tickets
Delta
Sep 6
MSY5:25 amNew Orleans Louis Armstrong
4h 02m
1 stop
TYS10:27 amKnoxville McGhee Tyson
Sep 11
TYS5:45 amKnoxville McGhee Tyson
3h 15m
1 stop
MSY8:00 amNew Orleans Louis Armstrong
$254
Find similar
Delta
Dec 13
MSY10:45 amNew Orleans Louis Armstrong
3h 20m
1 stop
TYS3:05 pmKnoxville McGhee Tyson
Dec 20
TYS6:36 pmKnoxville McGhee Tyson
5h 58m
1 stop
MSY11:34 pmNew Orleans Louis Armstrong
$308
Find similar

American Airlines flights from New Orleans to Knoxville

Our best American Airlines deals on New Orleans to Knoxville flight tickets
American Airlines
Sep 6
MSY7:00 amNew Orleans Louis Armstrong
5h 12m
1 stop
TYS1:12 pmKnoxville McGhee Tyson
Sep 11
TYS5:05 amKnoxville McGhee Tyson
4h 32m
1 stop
MSY8:37 amNew Orleans Louis Armstrong
$224
Find similar
American Airlines
Sep 25
MSY6:48 pmNew Orleans Louis Armstrong
4h 19m
1 stop
TYS12:07 amKnoxville McGhee Tyson
Sep 28
TYS8:36 pmKnoxville McGhee Tyson
4h 39m
1 stop
MSY12:15 amNew Orleans Louis Armstrong
$249
Find similar
American Airlines
Sep 5
MSY5:18 pmNew Orleans Louis Armstrong
5h 32m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Sep 8
TYS5:05 amKnoxville McGhee Tyson
7h 20m
1 stop
MSY11:25 amNew Orleans Louis Armstrong
$259
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 10/3

9:12 am-5:06 pm

1 stop6h 54m

Knoxville McGhee Tyson

Sun 10/5

7:20 am-4:04 pm

1 stop9h 44m

$199

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 9/18

7:20 pm-6:44 pm

1 stop22h 24m

Knoxville McGhee Tyson

Thu 9/25

5:55 pm-11:52 pm

1 stop6h 57m

$210

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 10/2

4:50 pm-5:06 pm

1 stop23h 16m

Knoxville McGhee Tyson

Thu 10/9

9:15 pm-6:50 pm

1 stop22h 35m

$215

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 9/25

9:10 am-5:05 pm

1 stop6h 55m

Knoxville McGhee Tyson

Sun 9/28

5:55 pm-8:07 am

1 stop15h 12m

$216

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 9/6

7:00 am-1:12 pm

1 stop5h 12m

Knoxville McGhee Tyson

Thu 9/11

5:05 am-8:37 am

1 stop4h 32m

$224

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 9/25

6:48 pm-12:07 am

1 stop4h 19m

Knoxville McGhee Tyson

Sun 9/28

8:36 pm-12:15 am

1 stop4h 39m

$249

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 9/6

5:25 am-10:27 am

1 stop4h 02m

Knoxville McGhee Tyson

Thu 9/11

5:45 am-8:00 am

1 stop3h 15m

$254

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 9/5

5:18 pm-11:50 pm

1 stop5h 32m

Knoxville McGhee Tyson

Mon 9/8

5:05 am-11:25 am

1 stop7h 20m

$259

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 10/2

6:48 pm-12:07 am

1 stop4h 19m

Knoxville McGhee Tyson

Sun 10/5

8:31 pm-12:15 am

1 stop4h 44m

$279

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 12/13

10:45 am-3:05 pm

1 stop3h 20m

Knoxville McGhee Tyson

Sat 12/20

6:36 pm-11:34 pm

1 stop5h 58m

$308

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from New Orleans to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from New Orleans, with most prices found around $263. If you aren’t able to travel during the month of July, then book flights to Knoxville from New Orleans during January instead. Flights to Knoxville in January, while not as cheap as those in July, still average around $275.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from New Orleans to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $314. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from New Orleans to Knoxville for around $403.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from New Orleans to Knoxville when you can find flight prices for as low as $321. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $365.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from New Orleans when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $329 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from New Orleans for as low as $268 on momondo.

How have New Orleans to Knoxville flight prices changed over time?

As of August 2025, prices for New Orleans to Knoxville flights are approximately 118% more expensive when compared to flights at the same time last year.

When to book flights from New Orleans to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from New Orleans to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap New Orleans to Knoxville (MSY to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from New Orleans to Knoxville

Direct flights

None
There are no direct flights from New Orleans to Knoxville. There are no popular flight routes from New Orleans to Knoxville.
Search flight deals

  • How far is New Orleans Louis Armstrong to Knoxville McGhee Tyson by plane?

    The straight-line distance from New Orleans Louis Armstrong to Knoxville McGhee Tyson is 546.5 mi. By plane, this route typically takes 3h 20m.

  • When did momondo last update prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from New Orleans to Knoxville?

Best airlines flying from New Orleans to Knoxville

Compare and see reviews for airlines that fly from New Orleans to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $198Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights
American AirlinesPriceFrom $227Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $237Free CancellationRating
7.9
7,981 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Lenoir City
Alcoa
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from New Orleans to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from New Orleans to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from New Orleans to Knoxville with flexible booking policies on momondo?

Flights from New Orleans to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from New Orleans to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from New Orleans.

I’m not ready to book a flight from New Orleans to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from New Orleans to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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