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Cheap flights from New Orleans to Knoxville from $104

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from New Orleans to Knoxville departing on 6/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from New Orleans to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
5:20 pm - 10:00 pm
MSY
-
TYS
27h 40m
2 stops
Multiple Airlines Logo
7:20 pm - 10:44 am
TYS
-
MSY
16h 24m
1 stop
$285Multiple Airlines
Thu, Jul 23 - Mon, Jul 27
Southwest Logo
10:25 am - 5:10 pm
MSY
-
TYS
5h 45m
1 stop
Southwest Logo
2:45 pm - 8:00 pm
TYS
-
MSY
6h 15m
1 stop
$295Southwest
Tue, Jun 2 - Tue, Jun 9
Multiple Airlines Logo
11:53 am - 9:15 pm
MSY
-
TYS
32h 22m
2 stops
Multiple Airlines Logo
7:20 pm - 10:44 am
TYS
-
MSY
16h 24m
1 stop
$296Multiple Airlines
Thu, Jul 30 - Mon, Aug 3
Southwest Logo
10:55 am - 8:50 pm
MSY
-
TYS
8h 55m
2 stops
Southwest Logo
6:55 pm - 11:15 pm
TYS
-
MSY
5h 20m
1 stop
$300Southwest
Tue, Jun 2 - Tue, Jun 9
Multiple Airlines Logo
6:17 am - 2:48 pm
MSY
-
TYS
7h 31m
1 stop
Multiple Airlines Logo
7:20 pm - 10:44 am
TYS
-
MSY
16h 24m
1 stop
$301Multiple Airlines
Thu, Jul 30 - Mon, Aug 3
Southwest Logo
10:55 am - 8:50 pm
MSY
-
TYS
8h 55m
2 stops
Southwest Logo
2:45 pm - 10:40 pm
TYS
-
MSY
8h 55m
2 stops
$305Southwest
Tue, Jun 2 - Tue, Jun 9
Southwest Logo
11:50 am - 9:15 pm
MSY
-
TYS
8h 25m
1 stop
Southwest Logo
7:10 am - 3:15 pm
TYS
-
MSY
9h 05m
2 stops
$306Southwest
Wed, Jun 24 - Wed, Jul 1
American Airlines Logo
7:00 am - 12:35 pm
MSY
-
TYS
4h 35m
1 stop
American Airlines Logo
5:00 am - 8:49 am
TYS
-
MSY
4h 49m
1 stop
$308American Airlines
Wed, May 27 - Mon, Jun 1
Southwest Logo
5:20 am - 6:20 pm
MSY
-
TYS
12h 00m
1 stop
Southwest Logo
8:10 am - 4:35 pm
TYS
-
MSY
9h 25m
2 stops
$314Southwest
Wed, Jun 17 - Wed, Jun 24
American Airlines Logo
4:17 pm - 11:47 pm
MSY
-
TYS
6h 30m
1 stop
American Airlines Logo
7:59 pm - 11:59 pm
TYS
-
MSY
5h 00m
1 stop
$321American Airlines
Mon, Jun 1 - Thu, Jun 4

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Southwest flights from New Orleans to Knoxville

Our best Southwest deals on New Orleans to Knoxville flight tickets
Southwest
Jun 2
MSY10:25 amNew Orleans Louis Armstrong
5h 45m
1 stop
TYS5:10 pmKnoxville McGhee Tyson
Jun 9
TYS2:45 pmKnoxville McGhee Tyson
6h 15m
1 stop
MSY8:00 pmNew Orleans Louis Armstrong
$295
Southwest
Jun 2
MSY10:55 amNew Orleans Louis Armstrong
8h 55m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
Jun 9
TYS6:55 pmKnoxville McGhee Tyson
5h 20m
1 stop
MSY11:15 pmNew Orleans Louis Armstrong
$300
Southwest
Jun 2
MSY10:55 amNew Orleans Louis Armstrong
8h 55m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
Jun 9
TYS2:45 pmKnoxville McGhee Tyson
8h 55m
2 stops
MSY10:40 pmNew Orleans Louis Armstrong
$305

American Airlines flights from New Orleans to Knoxville

Our best American Airlines deals on New Orleans to Knoxville flight tickets
American Airlines
May 27
MSY7:00 amNew Orleans Louis Armstrong
4h 35m
1 stop
TYS12:35 pmKnoxville McGhee Tyson
Jun 1
TYS5:00 amKnoxville McGhee Tyson
4h 49m
1 stop
MSY8:49 amNew Orleans Louis Armstrong
$308
American Airlines
Jun 1
MSY4:17 pmNew Orleans Louis Armstrong
6h 30m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
Jun 4
TYS7:59 pmKnoxville McGhee Tyson
5h 00m
1 stop
MSY11:59 pmNew Orleans Louis Armstrong
$321
American Airlines
Jun 5
MSY2:10 pmNew Orleans Louis Armstrong
6h 21m
1 stop
TYS9:31 pmKnoxville McGhee Tyson
Jun 10
TYS7:59 pmKnoxville McGhee Tyson
5h 00m
1 stop
MSY11:59 pmNew Orleans Louis Armstrong
$326

momondo Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 7/23

5:20 pm-10:00 pm

2 stops27h 40m

Knoxville McGhee Tyson

Mon 7/27

7:20 pm-10:44 am

1 stop16h 24m

$285

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 6/2

10:25 am-5:10 pm

1 stop5h 45m

Knoxville McGhee Tyson

Tue 6/9

2:45 pm-8:00 pm

1 stop6h 15m

$295

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 7/30

11:53 am-9:15 pm

2 stops32h 22m

Knoxville McGhee Tyson

Mon 8/3

7:20 pm-10:44 am

1 stop16h 24m

$296

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 6/2

10:55 am-8:50 pm

2 stops8h 55m

Knoxville McGhee Tyson

Tue 6/9

6:55 pm-11:15 pm

1 stop5h 20m

$300

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 7/30

6:17 am-2:48 pm

1 stop7h 31m

Knoxville McGhee Tyson

Mon 8/3

7:20 pm-10:44 am

1 stop16h 24m

$301

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Tue 6/2

10:55 am-8:50 pm

2 stops8h 55m

Knoxville McGhee Tyson

Tue 6/9

2:45 pm-10:40 pm

2 stops8h 55m

$305

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 6/24

11:50 am-9:15 pm

1 stop8h 25m

Knoxville McGhee Tyson

Wed 7/1

7:10 am-3:15 pm

2 stops9h 05m

$306
Quickest round-trip

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 5/27

7:00 am-12:35 pm

1 stop4h 35m

Knoxville McGhee Tyson

Mon 6/1

5:00 am-8:49 am

1 stop4h 49m

$308

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Wed 6/17

5:20 am-6:20 pm

1 stop12h 00m

Knoxville McGhee Tyson

Wed 6/24

8:10 am-4:35 pm

2 stops9h 25m

$314

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Mon 6/1

4:17 pm-11:47 pm

1 stop6h 30m

Knoxville McGhee Tyson

Thu 6/4

7:59 pm-11:59 pm

1 stop5h 00m

$321

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from New Orleans to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between New Orleans and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from New Orleans, with most prices found around $281. If you aren’t able to travel during the month of September, then book flights to Knoxville from New Orleans during August instead. Flights to Knoxville in August, while not as cheap as those in September, still average around $308.

How far in advance should I book a flight from New Orleans to Knoxville?

You are more likely to see cheaper flights to Knoxville from New Orleans when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from New Orleans for as low as $269 on momondo.

How have New Orleans to Knoxville flight prices changed over time?

As of May 2026, prices for New Orleans to Knoxville flights are approximately 68% cheaper when compared to flights at the same time last year.

When to book flights from New Orleans to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from New Orleans to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap New Orleans to Knoxville (MSY to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from New Orleans to Knoxville

Fastest flight time

4h 51m

Direct flights

None
The fastest flight from New Orleans to Knoxville takes 4h 51m
There are no direct flights from New Orleans to Knoxville. There are no popular flight routes from New Orleans to Knoxville.
Search flight deals

Frequently asked questions about flying from New Orleans to Knoxville

  • How far is New Orleans Louis Armstrong to Knoxville McGhee Tyson by plane?

    The straight-line distance from New Orleans Louis Armstrong to Knoxville McGhee Tyson is 546.5 mi. By plane, this route typically takes 4h 51m.

  • When did momondo last update prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from New Orleans to Knoxville?

Best airlines flying from New Orleans to Knoxville

Compare and see reviews for airlines that fly from New Orleans to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,666 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
8,458 reviews
Search Delta flights
SouthwestPriceFrom $294Free CancellationRating
7.9
4,305 reviews
Search Southwest flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from New Orleans to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from New Orleans to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from New Orleans to Knoxville with flexible booking policies on momondo?

Flights from New Orleans to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from New Orleans to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from New Orleans.

I’m not ready to book a flight from New Orleans to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from New Orleans to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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