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Cheap flights from New Orleans to Knoxville from $113

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from New Orleans to Knoxville departing on 12/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from New Orleans to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
4:31 pm - 8:33 amMSY-TYS
15h 02m1 stop
Multiple Airlines Logo
5:56 pm - 5:10 pmTYS-MSY
24h 14m2 stops
$204Multiple Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
Multiple Airlines Logo
6:10 pm - 11:11 pmMSY-TYS
28h 01m1 stop
Multiple Airlines Logo
6:30 am - 3:15 pmTYS-MSY
9h 45m1 stop
$212Multiple Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
Multiple Airlines Logo
9:51 pm - 11:11 pmMSY-TYS
24h 20m2 stops
Multiple Airlines Logo
5:56 pm - 5:10 pmTYS-MSY
24h 14m2 stops
$213Multiple Airlines
Find Deal
Thu, Dec 4 - Mon, Dec 8
Delta Logo
6:30 am - 1:26 pmMSY-TYS
5h 56m1 stop
Delta Logo
8:47 am - 12:09 pmTYS-MSY
4h 22m1 stop
$251Delta
Find Deal
Sat, Feb 21 - Tue, Feb 24
American Airlines Logo
6:23 am - 11:47 amMSY-TYS
4h 24m1 stop
American Airlines Logo
12:21 pm - 5:08 pmTYS-MSY
5h 47m1 stop
$260American Airlines
Find Deal
Sun, Feb 1 - Sat, Feb 7
Delta Logo
7:30 am - 2:48 pmMSY-TYS
6h 18m1 stop
Delta Logo
5:35 am - 9:37 amTYS-MSY
5h 02m1 stop
$269Delta
Find Deal
Thu, Nov 20 - Sun, Nov 23
American Airlines Logo
2:49 pm - 10:09 pmMSY-TYS
6h 20m1 stop
American Airlines Logo
5:00 am - 9:18 amTYS-MSY
5h 18m1 stop
$279American Airlines
Find Deal
Fri, Oct 24 - Tue, Oct 28
Delta Logo
4:52 pm - 11:46 pmMSY-TYS
5h 54m1 stop
Delta Logo
3:53 pm - 8:08 pmTYS-MSY
5h 15m1 stop
$285Delta
Find Deal
Fri, Nov 7 - Tue, Nov 11
American Airlines Logo
3:29 pm - 10:54 pmMSY-TYS
6h 25m1 stop
American Airlines Logo
4:27 pm - 9:07 pmTYS-MSY
5h 40m1 stop
$299American Airlines
Find Deal
Fri, Nov 21 - Sun, Nov 23
American Airlines Logo
10:27 am - 5:30 pmMSY-TYS
6h 03m1 stop
American Airlines Logo
7:01 pm - 11:59 pmTYS-MSY
5h 58m1 stop
$329American Airlines
Find Deal
Fri, Dec 19 - Mon, Dec 22

Delta flights from New Orleans to Knoxville

Our best Delta deals on New Orleans to Knoxville flight tickets
Delta
Feb 21
MSY6:30 amNew Orleans Louis Armstrong
5h 56m
1 stop
TYS1:26 pmKnoxville McGhee Tyson
Feb 24
TYS8:47 amKnoxville McGhee Tyson
4h 22m
1 stop
MSY12:09 pmNew Orleans Louis Armstrong
$251
Find similar
Delta
Nov 20
MSY7:30 amNew Orleans Louis Armstrong
6h 18m
1 stop
TYS2:48 pmKnoxville McGhee Tyson
Nov 23
TYS5:35 amKnoxville McGhee Tyson
5h 02m
1 stop
MSY9:37 amNew Orleans Louis Armstrong
$269
Find similar
Delta
Nov 7
MSY4:52 pmNew Orleans Louis Armstrong
5h 54m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Nov 11
TYS3:53 pmKnoxville McGhee Tyson
5h 15m
1 stop
MSY8:08 pmNew Orleans Louis Armstrong
$285
Find similar

American Airlines flights from New Orleans to Knoxville

Our best American Airlines deals on New Orleans to Knoxville flight tickets
American Airlines
Feb 1
MSY6:23 amNew Orleans Louis Armstrong
4h 24m
1 stop
TYS11:47 amKnoxville McGhee Tyson
Feb 7
TYS12:21 pmKnoxville McGhee Tyson
5h 47m
1 stop
MSY5:08 pmNew Orleans Louis Armstrong
$260
Find similar
American Airlines
Oct 22
MSY2:49 pmNew Orleans Louis Armstrong
6h 20m
1 stop
TYS10:09 pmKnoxville McGhee Tyson
Oct 26
TYS5:00 amKnoxville McGhee Tyson
5h 56m
1 stop
MSY9:56 amNew Orleans Louis Armstrong
$279
Find similar
American Airlines
Nov 21
MSY3:29 pmNew Orleans Louis Armstrong
6h 25m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
Nov 23
TYS4:27 pmKnoxville McGhee Tyson
5h 40m
1 stop
MSY9:07 pmNew Orleans Louis Armstrong
$299
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from New Orleans to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 9, 2025.
Use the filters below to find and compare flights from New Orleans to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/4

4:31 pm-8:33 am

1 stop15h 02m

Knoxville McGhee Tyson

Mon 12/8

5:56 pm-5:10 pm

2 stops24h 14m

$204

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/4

6:10 pm-11:11 pm

1 stop28h 01m

Knoxville McGhee Tyson

Mon 12/8

6:30 am-3:15 pm

1 stop9h 45m

$212

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 12/4

9:51 pm-11:11 pm

2 stops24h 20m

Knoxville McGhee Tyson

Mon 12/8

5:56 pm-5:10 pm

2 stops24h 14m

$213

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sat 2/21

6:30 am-1:26 pm

1 stop5h 56m

Knoxville McGhee Tyson

Tue 2/24

8:47 am-12:09 pm

1 stop4h 22m

$251

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Sun 2/1

6:23 am-11:47 am

1 stop4h 24m

Knoxville McGhee Tyson

Sat 2/7

12:21 pm-5:08 pm

1 stop5h 47m

$260

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Thu 11/20

7:30 am-2:48 pm

1 stop6h 18m

Knoxville McGhee Tyson

Sun 11/23

5:35 am-9:37 am

1 stop5h 02m

$269

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 10/24

2:49 pm-10:09 pm

1 stop6h 20m

Knoxville McGhee Tyson

Tue 10/28

5:00 am-9:18 am

1 stop5h 18m

$279

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 11/7

4:52 pm-11:46 pm

1 stop5h 54m

Knoxville McGhee Tyson

Tue 11/11

3:53 pm-8:08 pm

1 stop5h 15m

$285

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 11/21

3:29 pm-10:54 pm

1 stop6h 25m

Knoxville McGhee Tyson

Sun 11/23

4:27 pm-9:07 pm

1 stop5h 40m

$299

New OrleansKnoxville

MSY - TYS

MSYTYS

New Orleans Louis Armstrong

Fri 12/19

10:27 am-5:30 pm

1 stop6h 03m

Knoxville McGhee Tyson

Mon 12/22

7:01 pm-11:59 pm

1 stop5h 58m

$329

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from New Orleans to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from New Orleans, with most prices found around $263. If you aren’t able to travel during the month of July, then book flights to Knoxville from New Orleans during January instead. Flights to Knoxville in January, while not as cheap as those in July, still average around $278.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from New Orleans to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $314. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from New Orleans to Knoxville for around $403.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from New Orleans to Knoxville when you can find flight prices for as low as $321. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $365.

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from New Orleans when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $330 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from New Orleans for as low as $274 on momondo.

How have New Orleans to Knoxville flight prices changed over time?

As of October 2025, prices for New Orleans to Knoxville flights are approximately 4% cheaper when compared to flights at the same time last year.

When to book flights from New Orleans to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from New Orleans to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap New Orleans to Knoxville (MSY to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from New Orleans to Knoxville

Direct flights

None
There are no direct flights from New Orleans to Knoxville. There are no popular flight routes from New Orleans to Knoxville.
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  • How far is New Orleans Louis Armstrong to Knoxville McGhee Tyson by plane?

    The straight-line distance from New Orleans Louis Armstrong to Knoxville McGhee Tyson is 546.5 mi. By plane, this route typically takes 3h 06m.

  • When did momondo last update prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from New Orleans Louis Armstrong Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from New Orleans to Knoxville?

Best airlines flying from New Orleans to Knoxville

Compare and see reviews for airlines that fly from New Orleans to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $198Free CancellationRating
7.4
8,968 reviews
Search United Airlines flights
American AirlinesPriceFrom $245Free CancellationRating
7.2
11,043 reviews
Search American Airlines flights
DeltaPriceFrom $248Free CancellationRating
7.9
7,969 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from New Orleans to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from New Orleans to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from New Orleans to Knoxville with flexible booking policies on momondo?

Flights from New Orleans to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from New Orleans to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from New Orleans.

I’m not ready to book a flight from New Orleans to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from New Orleans to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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