When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

As of August 2025, there are 2 operators available to choose from for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$147 Cheap Flights from Myrtle Beach to Knoxville in 2025

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Myrtle Beach to Knoxville

Round-trip

One-way

Last minute

Cheap round-trip flights

5:36 pm - 11:03 pmMYR-TYS

5h 27m1 stop

7:45 pm - 11:10 pmTYS-MYR

3h 25m1 stop

$229American Airlines

Find Deal

Wed, Sep 10 - Tue, Sep 23

4:15 pm - 11:18 amMYR-TYS

19h 03m2 stops

11:25 am - 12:29 pmTYS-MYR

25h 04m1 stop

$240

Find Deal

Wed, Sep 10 - Tue, Sep 23

2:00 pm - 11:18 amMYR-TYS

21h 18m2 stops

3:19 pm - 9:21 amTYS-MYR

18h 02m2 stops

$286

Find Deal

Wed, Sep 3 - Sun, Sep 7

9:38 am - 2:29 pmMYR-TYS

4h 51m1 stop

5:26 pm - 11:11 pmTYS-MYR

5h 45m1 stop

$289American Airlines

Find Deal

Sat, Aug 23 - Mon, Aug 25

7:43 pm - 3:41 pmMYR-TYS

19h 58m2 stops

9:31 pm - 4:44 pmTYS-MYR

19h 13m2 stops

$292

Find Deal

Tue, Sep 2 - Sat, Sep 6

6:00 am - 5:34 pmMYR-TYS

11h 34m2 stops

8:49 pm - 1:50 pmTYS-MYR

17h 01m2 stops

$295

Find Deal

Mon, Sep 8 - Fri, Sep 12

5:34 pm - 10:07 amMYR-TYS

40h 33m2 stops

5:55 pm - 8:06 pmTYS-MYR

26h 11m1 stop

$296

Find Deal

Thu, Sep 18 - Thu, Sep 25

4:45 pm - 10:45 pmMYR-TYS

6h 00m1 stop

7:00 am - 4:27 pmTYS-MYR

9h 27m2 stops

$368United Airlines

Find Deal

Tue, Sep 2 - Sat, Sep 6

4:45 pm - 10:45 pmMYR-TYS

6h 00m1 stop

9:55 am - 2:06 pmTYS-MYR

4h 11m1 stop

$378United Airlines

Find Deal

Tue, Sep 2 - Sat, Sep 6

6:58 pm - 11:46 pmMYR-TYS

4h 48m1 stop

5:44 am - 9:51 amTYS-MYR

4h 07m1 stop

$409Delta

Find Deal

Mon, Oct 20 - Wed, Oct 22

American Airlines flights from Myrtle Beach to Knoxville

Our best American Airlines deals on Myrtle Beach to Knoxville flight tickets

American Airlines

Sep 10

MYR5:36 pmMyrtle Beach Intl

5h 27m

1 stop

TYS11:03 pmKnoxville McGhee Tyson

Sep 23

TYS7:45 pmKnoxville McGhee Tyson

3h 25m

1 stop

MYR11:10 pmMyrtle Beach Intl

$229

Find similar

American Airlines

Aug 23

MYR9:38 amMyrtle Beach Intl

4h 51m

1 stop

TYS2:29 pmKnoxville McGhee Tyson

Aug 25

TYS5:26 pmKnoxville McGhee Tyson

5h 45m

1 stop

MYR11:11 pmMyrtle Beach Intl

$289

Find similar

American Airlines

Sep 3

MYR8:06 amMyrtle Beach Intl

5h 37m

1 stop

TYS1:43 pmKnoxville McGhee Tyson

Sep 7

TYS5:05 amKnoxville McGhee Tyson

5h 21m

1 stop

MYR10:26 amMyrtle Beach Intl

$303

Find similar

United Airlines flights from Myrtle Beach to Knoxville

Our best United Airlines deals on Myrtle Beach to Knoxville flight tickets

United Airlines

Sep 2

MYR4:45 pmMyrtle Beach Intl

6h 00m

1 stop

TYS10:45 pmKnoxville McGhee Tyson

Sep 6

TYS7:00 amKnoxville McGhee Tyson

9h 27m

2 stops

MYR4:27 pmMyrtle Beach Intl

$368

Find similar

United Airlines

Sep 2

MYR4:45 pmMyrtle Beach Intl

6h 00m

1 stop

TYS10:45 pmKnoxville McGhee Tyson

Sep 6

TYS9:55 amKnoxville McGhee Tyson

4h 11m

1 stop

MYR2:06 pmMyrtle Beach Intl

$378

Find similar

United Airlines

Sep 12

MYR4:45 pmMyrtle Beach Intl

5h 51m

1 stop

TYS10:36 pmKnoxville McGhee Tyson

Sep 14

TYS7:00 amKnoxville McGhee Tyson

7h 42m

1 stop

MYR2:42 pmMyrtle Beach Intl

$486

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 9/10

5:36 pm-11:03 pm

1 stop5h 27m

Knoxville McGhee Tyson

Tue 9/23

7:45 pm-11:10 pm

1 stop3h 25m

$229

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 9/10

4:15 pm-11:18 am

2 stops19h 03m

Knoxville McGhee Tyson

Tue 9/23

11:25 am-12:29 pm

1 stop25h 04m

$240

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 9/3

2:00 pm-11:18 am

2 stops21h 18m

Knoxville McGhee Tyson

Sun 9/7

3:19 pm-9:21 am

2 stops18h 02m

$286

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 8/23

9:38 am-2:29 pm

1 stop4h 51m

Knoxville McGhee Tyson

Mon 8/25

5:26 pm-11:11 pm

1 stop5h 45m

$289

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 9/2

7:43 pm-3:41 pm

2 stops19h 58m

Knoxville McGhee Tyson

Sat 9/6

9:31 pm-4:44 pm

2 stops19h 13m

$292

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 9/8

6:00 am-5:34 pm

2 stops11h 34m

Knoxville McGhee Tyson

Fri 9/12

8:49 pm-1:50 pm

2 stops17h 01m

$295

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 9/18

5:34 pm-10:07 am

2 stops40h 33m

Knoxville McGhee Tyson

Thu 9/25

5:55 pm-8:06 pm

1 stop26h 11m

$296

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 9/2

4:45 pm-10:45 pm

1 stop6h 00m

Knoxville McGhee Tyson

Sat 9/6

7:00 am-4:27 pm

2 stops9h 27m

$368

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 9/2

4:45 pm-10:45 pm

1 stop6h 00m

Knoxville McGhee Tyson

Sat 9/6

9:55 am-2:06 pm

1 stop4h 11m

$378

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 10/20

6:58 pm-11:46 pm

1 stop4h 48m

Knoxville McGhee Tyson

Wed 10/22

5:44 am-9:51 am

1 stop4h 07m

$409

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Myrtle Beach to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of March is, on average, the cheapest month to fly to Knoxville from Myrtle Beach, with most prices found around $278. If you aren’t able to travel during the month of March, then book flights to Knoxville from Myrtle Beach during September instead. Flights to Knoxville in September, while not as cheap as those in March, still average around $288.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Myrtle Beach to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $283. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Myrtle Beach to Knoxville for around $598.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Myrtle Beach to Knoxville when you can find flight prices for as low as $338. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $479.

When to book flights from Myrtle Beach to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Myrtle Beach to Knoxville (MYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Knoxville

Direct flights	None

There are no direct flights from Myrtle Beach to Knoxville. There are no popular flight routes from Myrtle Beach to Knoxville.

Search flight deals

How far is Myrtle Beach Intl to Knoxville McGhee Tyson by plane?
A flight from Myrtle Beach Intl to Knoxville McGhee Tyson will travel around 325.5 mi. By plane, this route typically takes 4h 46m.
When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?
As of August 2025, there are 2 operators available to choose from for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Myrtle Beach to Knoxville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Myrtle Beach to Knoxville is American Airlines (78% of total bookings). The next most popular airline is Delta (22%).

Best airlines flying from Myrtle Beach to Knoxville

Compare and see reviews for airlines that fly from Myrtle Beach to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $198	Free Cancellation	Rating 7.9 7,982 reviews		Search Delta flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.2 10,000 reviews		Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Newport

Lenoir City

Alcoa

Oak Ridge

Kodak

Dandridge

Clinton

Jefferson City

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Knoxville?

Once all potential Myrtle Beach to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.