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Cheap flights from Myrtle Beach to Knoxville from $120

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
3:25 pm - 8:50 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
5h 25m1 stop Baltimore/Washington
Southwest Logo
7:25 pm - 9:55 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
14h 30m2 stops Nashville Intl Baltimore/Washington
$272Southwest
Wed, Nov 11 - Fri, Nov 13
Delta Logo
6:51 pm - 10:12 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 21m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:00 am - 10:07 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 07m1 stop Atlanta Hartsfield-Jackson
$313Delta
Sat, Nov 21 - Mon, Nov 23
Multiple Airlines Logo
2:42 pm - 8:05 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
17h 23m1 stop Fort Lauderdale
Multiple Airlines Logo
6:36 pm - 8:50 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
14h 14m1 stop Orlando Sanford Intl
$317Multiple Airlines
Wed, Nov 11 - Fri, Nov 13
Southwest Logo
8:10 am - 7:50 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
11h 40m2 stops Baltimore/Washington Nashville Intl
Southwest Logo
7:25 pm - 9:55 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
14h 30m2 stops Nashville Intl Baltimore/Washington
$354Southwest
Wed, Nov 11 - Fri, Nov 13
American Airlines Logo
8:44 pm - 11:59 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 15m1 stop Charlotte Douglas
American Airlines Logo
8:04 pm - 11:54 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 50m1 stop Charlotte Douglas
$367American Airlines
Mon, Nov 23 - Fri, Nov 27
American Airlines Logo
8:07 am - 1:42 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
5h 35m1 stop Charlotte Douglas
American Airlines Logo
4:32 pm - 10:03 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
5h 31m1 stop Charlotte Douglas
$367American Airlines
Wed, Nov 18 - Thu, Nov 19
Delta Logo
6:00 am - 11:06 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
5h 06m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:57 pm - 10:25 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
4h 28m1 stop Atlanta Hartsfield-Jackson
$367Delta
Sat, Jan 9 - Wed, Jan 13
Southwest Logo
8:10 am - 5:40 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
9h 30m2 stops Baltimore/Washington Nashville Intl
Southwest Logo
7:00 am - 1:05 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
6h 05m1 stop Nashville Intl
$372Southwest
Sat, Jan 9 - Wed, Jan 13
Southwest Logo
3:25 pm - 8:50 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
5h 25m1 stop Baltimore/Washington
Southwest Logo
7:15 pm - 9:55 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
14h 40m2 stops Nashville Intl Baltimore/Washington
$374Southwest
Wed, Nov 18 - Wed, Nov 25
Delta Logo
2:18 pm - 5:22 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 04m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:00 am - 10:07 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 07m1 stop Atlanta Hartsfield-Jackson
$374Delta
Mon, Nov 23 - Fri, Nov 27

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United Airlines flights from Myrtle Beach to Knoxville

Our best United Airlines deals on Myrtle Beach to Knoxville flight tickets
United Airlines
Nov 11
MYR11:27 amMyrtle Beach Intl
24h 03m
2 stops
TYS11:30 amKnoxville McGhee Tyson
Nov 13
TYS5:40 pmKnoxville McGhee Tyson
23h 31m
3 stops
MYR5:11 pmMyrtle Beach Intl
$807
United Airlines
Nov 3
MYR5:54 pmMyrtle Beach Intl
20h 54m
2 stops
TYS2:48 pmKnoxville McGhee Tyson
Nov 7
TYS9:45 amKnoxville McGhee Tyson
24h 36m
2 stops
MYR10:21 amMyrtle Beach Intl
$847
United Airlines
Nov 23
MYR5:54 pmMyrtle Beach Intl
17h 36m
2 stops
TYS11:30 amKnoxville McGhee Tyson
Nov 27
TYS5:45 amKnoxville McGhee Tyson
11h 26m
2 stops
MYR5:11 pmMyrtle Beach Intl
$892

American Airlines flights from Myrtle Beach to Knoxville

Our best American Airlines deals on Myrtle Beach to Knoxville flight tickets
American Airlines
Nov 23
MYR8:44 pmMyrtle Beach Intl
3h 15m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Nov 27
TYS6:50 amKnoxville McGhee Tyson
3h 30m
1 stop
MYR10:20 amMyrtle Beach Intl
$367
American Airlines
Nov 23
MYR8:44 pmMyrtle Beach Intl
3h 15m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Nov 27
TYS7:01 amKnoxville McGhee Tyson
4h 15m
1 stop
MYR11:16 amMyrtle Beach Intl
$413
American Airlines
Dec 21
MYR8:09 pmMyrtle Beach Intl
3h 44m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
Dec 27
TYS8:01 pmKnoxville McGhee Tyson
3h 48m
1 stop
MYR11:49 pmMyrtle Beach Intl
$475

momondo Fare Finder

 
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

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Cheapest round-trip

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Wed 11/11

3:25 pm-8:50 pm

1 stop5h 25m

Knoxville McGhee Tyson

Fri 11/13

7:25 pm-9:55 am

2 stops14h 30m

$272

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Sat 11/21

6:51 pm-10:12 pm

1 stop3h 21m

Knoxville McGhee Tyson

Mon 11/23

7:00 am-10:07 am

1 stop3h 07m

$313

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Wed 11/11

2:42 pm-8:05 am

1 stop17h 23m

Knoxville McGhee Tyson

Fri 11/13

6:36 pm-8:50 am

1 stop14h 14m

$317

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Wed 11/11

8:10 am-7:50 pm

2 stops11h 40m

Knoxville McGhee Tyson

Fri 11/13

7:25 pm-9:55 am

2 stops14h 30m

$354

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Mon 11/23

8:44 pm-11:59 pm

1 stop3h 15m

Knoxville McGhee Tyson

Fri 11/27

8:04 pm-11:54 pm

1 stop3h 50m

$367

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Wed 11/18

8:07 am-1:42 pm

1 stop5h 35m

Knoxville McGhee Tyson

Thu 11/19

4:32 pm-10:03 pm

1 stop5h 31m

$367

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Sat 1/9

6:00 am-11:06 am

1 stop5h 06m

Knoxville McGhee Tyson

Wed 1/13

5:57 pm-10:25 pm

1 stop4h 28m

$367

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Sat 1/9

8:10 am-5:40 pm

2 stops9h 30m

Knoxville McGhee Tyson

Wed 1/13

7:00 am-1:05 pm

1 stop6h 05m

$372

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Wed 11/18

3:25 pm-8:50 pm

1 stop5h 25m

Knoxville McGhee Tyson

Wed 11/25

7:15 pm-9:55 am

2 stops14h 40m

$374
Quickest round-trip

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Mon 11/23

2:18 pm-5:22 pm

1 stop3h 04m

Knoxville McGhee Tyson

Fri 11/27

7:00 am-10:07 am

1 stop3h 07m

$374

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Myrtle Beach to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Myrtle Beach Intl to Knoxville McGhee Tyson?

American Airlines and Southwest are the most popular carriers operating from Myrtle Beach Intl to Knoxville McGhee Tyson

When to book flights from Myrtle Beach to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Knoxville (MYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Knoxville

Best Price Found

$120

Fastest flight time

8h 05m

Direct flights

None
The best one-way flight to Knoxville from Myrtle Beach in the past 72 hours is $120. The best round-trip flight deal from Myrtle Beach to Knoxville found on momondo in the last 72 hours is $272.
The fastest flight from Myrtle Beach to Knoxville takes 8h 05m
There are no direct flights from Myrtle Beach to Knoxville. There are no popular flight routes from Myrtle Beach to Knoxville.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Knoxville

  • How far is Myrtle Beach Intl to Knoxville McGhee Tyson by plane?

    A flight from Myrtle Beach Intl to Knoxville McGhee Tyson will travel around 325.5 mi. By plane, this route typically takes 8h 05m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Myrtle Beach to Knoxville?

Best airlines flying from Myrtle Beach to Knoxville

Compare and see reviews for airlines that fly from Myrtle Beach to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $317Free CancellationRating
7.0
12,184 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Kodak
Lenoir City
Newport
Dandridge
Clinton
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Knoxville?

Once all potential Myrtle Beach to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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