When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

As of November 2025, there is 1 operator available to choose from for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$149 Cheap Flights from Myrtle Beach to Knoxville in 2025/26

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Find the cheapest flights from Myrtle Beach to Knoxville

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9:54 am - 2:03 pmMYR-TYS

28h 09m1 stop

8:53 am - 6:08 pmTYS-MYR

9h 15m1 stop

$287Multiple Airlines

Find Deal

Tue, Dec 16 - Fri, Dec 19

10:45 am - 8:18 amMYR-TYS

45h 33m2 stops

8:53 am - 6:08 pmTYS-MYR

9h 15m1 stop

$302Multiple Airlines

Find Deal

Tue, Dec 16 - Fri, Dec 19

9:05 am - 2:55 pmMYR-TYS

5h 50m1 stop

2:53 pm - 6:08 pmTYS-MYR

27h 15m1 stop

$324Multiple Airlines

Find Deal

Sat, Dec 13 - Wed, Dec 17

9:05 am - 2:55 pmMYR-TYS

5h 50m1 stop

2:53 pm - 8:49 amTYS-MYR

17h 56m2 stops

$347Multiple Airlines

Find Deal

Sat, Dec 13 - Wed, Dec 17

9:05 am - 2:55 pmMYR-TYS

5h 50m1 stop

7:02 pm - 6:08 pmTYS-MYR

23h 06m3 stops

$369Multiple Airlines

Find Deal

Sat, Dec 13 - Wed, Dec 17

9:05 am - 2:03 pmMYR-TYS

28h 58m3 stops

8:53 am - 6:08 pmTYS-MYR

9h 15m1 stop

$372Multiple Airlines

Find Deal

Tue, Dec 16 - Fri, Dec 19

6:56 pm - 11:28 pmMYR-TYS

4h 32m1 stop

5:40 am - 9:47 amTYS-MYR

4h 07m1 stop

$407Delta

Find Deal

Thu, Dec 11 - Sun, Dec 14

9:05 am - 2:03 pmMYR-TYS

28h 58m3 stops

8:53 am - 11:59 pmTYS-MYR

15h 06m2 stops

$411Multiple Airlines

Find Deal

Tue, Dec 16 - Fri, Dec 19

2:40 pm - 6:52 pmMYR-TYS

4h 12m1 stop

5:40 am - 9:47 amTYS-MYR

4h 07m1 stop

$417Delta

Find Deal

Mon, Dec 15 - Fri, Dec 19

9:54 am - 11:31 amMYR-TYS

25h 37m2 stops

7:02 pm - 6:08 pmTYS-MYR

23h 06m3 stops

$435Multiple Airlines

Find Deal

Sat, Dec 13 - Wed, Dec 17

Delta flights from Myrtle Beach to Knoxville

Our best Delta deals on Myrtle Beach to Knoxville flight tickets

Delta

Dec 11

MYR6:56 pmMyrtle Beach Intl

4h 32m

1 stop

TYS11:28 pmKnoxville McGhee Tyson

Dec 14

TYS5:40 amKnoxville McGhee Tyson

4h 07m

1 stop

MYR9:47 amMyrtle Beach Intl

$407

Find similar

Delta

Dec 15

MYR2:40 pmMyrtle Beach Intl

4h 12m

1 stop

TYS6:52 pmKnoxville McGhee Tyson

Dec 19

TYS5:40 amKnoxville McGhee Tyson

4h 07m

1 stop

MYR9:47 amMyrtle Beach Intl

$417

Find similar

Delta

Dec 23

MYR3:39 pmMyrtle Beach Intl

3h 48m

1 stop

TYS7:27 pmKnoxville McGhee Tyson

Jan 6

TYS5:40 amKnoxville McGhee Tyson

4h 06m

1 stop

MYR9:46 amMyrtle Beach Intl

$448

Find similar

American Airlines flights from Myrtle Beach to Knoxville

Our best American Airlines deals on Myrtle Beach to Knoxville flight tickets

American Airlines

Dec 6

MYR6:00 amMyrtle Beach Intl

4h 33m

1 stop

TYS10:33 amKnoxville McGhee Tyson

Dec 9

TYS5:09 pmKnoxville McGhee Tyson

3h 41m

1 stop

MYR8:50 pmMyrtle Beach Intl

$435

Find similar

American Airlines

Dec 11

MYR6:00 amMyrtle Beach Intl

10h 33m

2 stops

TYS4:33 pmKnoxville McGhee Tyson

Dec 14

TYS6:40 amKnoxville McGhee Tyson

4h 02m

1 stop

MYR10:42 amMyrtle Beach Intl

$492

Find similar

American Airlines

Dec 4

MYR8:11 pmMyrtle Beach Intl

3h 46m

1 stop

TYS11:57 pmKnoxville McGhee Tyson

Dec 9

TYS10:20 amKnoxville McGhee Tyson

4h 24m

1 stop

MYR2:44 pmMyrtle Beach Intl

$516

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 12/16

9:54 am-2:03 pm

1 stop28h 09m

Knoxville McGhee Tyson

Fri 12/19

8:53 am-6:08 pm

1 stop9h 15m

$287

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 12/16

10:45 am-8:18 am

2 stops45h 33m

Knoxville McGhee Tyson

Fri 12/19

8:53 am-6:08 pm

1 stop9h 15m

$302

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 12/13

9:05 am-2:55 pm

1 stop5h 50m

Knoxville McGhee Tyson

Wed 12/17

2:53 pm-6:08 pm

1 stop27h 15m

$324

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 12/13

9:05 am-2:55 pm

1 stop5h 50m

Knoxville McGhee Tyson

Wed 12/17

2:53 pm-8:49 am

2 stops17h 56m

$347

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 12/13

9:05 am-2:55 pm

1 stop5h 50m

Knoxville McGhee Tyson

Wed 12/17

7:02 pm-6:08 pm

3 stops23h 06m

$369

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 12/16

9:05 am-2:03 pm

3 stops28h 58m

Knoxville McGhee Tyson

Fri 12/19

8:53 am-6:08 pm

1 stop9h 15m

$372

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 12/11

6:56 pm-11:28 pm

1 stop4h 32m

Knoxville McGhee Tyson

Sun 12/14

5:40 am-9:47 am

1 stop4h 07m

$407

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 12/16

9:05 am-2:03 pm

3 stops28h 58m

Knoxville McGhee Tyson

Fri 12/19

8:53 am-11:59 pm

2 stops15h 06m

$411

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 12/15

2:40 pm-6:52 pm

1 stop4h 12m

Knoxville McGhee Tyson

Fri 12/19

5:40 am-9:47 am

1 stop4h 07m

$417

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 12/13

9:54 am-11:31 am

2 stops25h 37m

Knoxville McGhee Tyson

Wed 12/17

7:02 pm-6:08 pm

3 stops23h 06m

$435

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Myrtle Beach to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Myrtle Beach, with most prices found around $228. If you aren’t able to travel during the month of September, then book flights to Knoxville from Myrtle Beach during March instead. Flights to Knoxville in March, while not as cheap as those in September, still average around $278.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Myrtle Beach to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $283. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Myrtle Beach to Knoxville for around $598.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Myrtle Beach to Knoxville when you can find flight prices for as low as $338. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $479.

When to book flights from Myrtle Beach to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Knoxville according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Myrtle Beach to Knoxville (MYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Knoxville

Fastest flight time	3h 21m
Direct flights	None

The fastest flight from Myrtle Beach to Knoxville takes 3h 21m

There are no direct flights from Myrtle Beach to Knoxville. There are no popular flight routes from Myrtle Beach to Knoxville.

Search flight deals

How far is Myrtle Beach Intl to Knoxville McGhee Tyson by plane?
A flight from Myrtle Beach Intl to Knoxville McGhee Tyson will travel around 325.5 mi. By plane, this route typically takes 3h 48m.
When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?
Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.
How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?
As of November 2025, there is 1 operator available to choose from for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Myrtle Beach to Knoxville?
Based on momondo bookings for this flight route, the most popular airline on flight routes from Myrtle Beach to Knoxville is American Airlines (100% of total bookings).

Best airlines flying from Myrtle Beach to Knoxville

Compare and see reviews for airlines that fly from Myrtle Beach to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.2 11,042 reviews		Search American Airlines flights

Pigeon Forge

Gatlinburg

Cherokee

Bryson City

Morristown

Corbin

Crossville

Maryville

Murphy

Alcoa

Oak Ridge

Lenoir City

Newport

Kodak

Dandridge

Jefferson City

Clinton

Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Knoxville?

Once all potential Myrtle Beach to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.