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Cheap flights from Myrtle Beach to Knoxville from $207

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
10:35 am - 5:40 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
7h 05m1 stop Nashville Intl
Southwest Logo
7:05 am - 1:15 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
6h 10m1 stop Nashville Intl
$278Southwest
Sat, Nov 7 - Tue, Nov 10
Multiple Airlines Logo
4:03 pm - 10:05 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
18h 02m1 stop Fort Lauderdale
Multiple Airlines Logo
9:24 pm - 9:13 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
11h 49m1 stop Fort Lauderdale
$312Multiple Airlines
Tue, Oct 13 - Fri, Oct 16
American Airlines Logo
8:12 pm - 11:55 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 43m1 stop Charlotte Douglas
American Airlines Logo
10:00 am - 1:31 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 31m1 stop Charlotte Douglas
$319American Airlines
Mon, Oct 5 - Thu, Oct 29
Multiple Airlines Logo
10:50 am - 10:04 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
23h 14m1 stop Fort Lauderdale
Multiple Airlines Logo
5:18 pm - 12:14 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
18h 56m1 stop Tampa St. Petersburg
$323Multiple Airlines
Tue, Sep 22 - Wed, Sep 23
Southwest Logo
1:40 pm - 9:40 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
8h 00m1 stop Baltimore/Washington
Southwest Logo
8:10 am - 6:55 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
10h 45m1 stop Baltimore/Washington
$330Southwest
Mon, Nov 9 - Fri, Nov 13
American Airlines Logo
6:12 am - 9:45 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 33m1 stop Charlotte Douglas
American Airlines Logo
6:07 pm - 10:04 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 57m1 stop Charlotte Douglas
$333American Airlines
Mon, Nov 9 - Sun, Nov 15
American Airlines Logo
5:10 am - 8:49 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 39m1 stop Charlotte Douglas
American Airlines Logo
8:04 pm - 11:55 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 51m1 stop Charlotte Douglas
$333American Airlines
Fri, Nov 27 - Sun, Dec 6
Southwest Logo
1:40 pm - 9:40 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
8h 00m1 stop Baltimore/Washington
Southwest Logo
7:25 pm - 9:55 amTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
14h 30m2 stops Nashville Intl Baltimore/Washington
$335Southwest
Mon, Nov 9 - Fri, Nov 13
Multiple Airlines Logo
1:53 pm - 5:14 pmMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
27h 21m1 stop Fort Lauderdale
Multiple Airlines Logo
6:24 pm - 2:02 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
43h 38m2 stops Jacksonville Akron/Canton
$339Multiple Airlines
Mon, Oct 5 - Thu, Oct 29
American Airlines Logo
5:10 am - 8:48 amMYR  Myrtle Beach Intl-TYS Knoxville McGhee Tyson
3h 38m1 stop Charlotte Douglas
American Airlines Logo
8:04 pm - 11:55 pmTYS  Knoxville McGhee Tyson-MYR Myrtle Beach Intl
3h 51m1 stop Charlotte Douglas
$347American Airlines
Fri, Nov 13 - Fri, Nov 13

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American Airlines flights from Myrtle Beach to Knoxville

Our best American Airlines deals on Myrtle Beach to Knoxville flight tickets
American Airlines
Nov 9
MYR6:12 amMyrtle Beach Intl
3h 33m
1 stop
TYS9:45 amKnoxville McGhee Tyson
Nov 15
TYS6:07 pmKnoxville McGhee Tyson
3h 57m
1 stop
MYR10:04 pmMyrtle Beach Intl
$333
American Airlines
Nov 13
MYR5:10 amMyrtle Beach Intl
3h 38m
1 stop
TYS8:48 amKnoxville McGhee Tyson
Nov 13
TYS8:04 pmKnoxville McGhee Tyson
3h 51m
1 stop
MYR11:55 pmMyrtle Beach Intl
$347
American Airlines
Nov 23
MYR4:12 pmMyrtle Beach Intl
5h 29m
1 stop
TYS9:41 pmKnoxville McGhee Tyson
Nov 27
TYS7:01 amKnoxville McGhee Tyson
4h 15m
1 stop
MYR11:16 amMyrtle Beach Intl
$378

Southwest flights from Myrtle Beach to Knoxville

Our best Southwest deals on Myrtle Beach to Knoxville flight tickets
Southwest
Nov 7
MYR10:35 amMyrtle Beach Intl
7h 05m
1 stop
TYS5:40 pmKnoxville McGhee Tyson
Nov 10
TYS7:05 amKnoxville McGhee Tyson
6h 10m
1 stop
MYR1:15 pmMyrtle Beach Intl
$278
Southwest
Oct 22
MYR3:55 pmMyrtle Beach Intl
6h 50m
1 stop
TYS10:45 pmKnoxville McGhee Tyson
Oct 27
TYS7:15 amKnoxville McGhee Tyson
5h 40m
1 stop
MYR12:55 pmMyrtle Beach Intl
$313
Southwest
Nov 15
MYR10:45 amMyrtle Beach Intl
9h 45m
1 stop
TYS8:30 pmKnoxville McGhee Tyson
Nov 19
TYS7:05 amKnoxville McGhee Tyson
6h 10m
1 stop
MYR1:15 pmMyrtle Beach Intl
$315

momondo Fare Finder

 
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

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Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Sat 11/7

10:35 am-5:40 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 11/10

7:05 am-1:15 pm

1 stop6h 10m

$278

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Tue 10/13

4:03 pm-10:05 am

1 stop18h 02m

Knoxville McGhee Tyson

Fri 10/16

9:24 pm-9:13 am

1 stop11h 49m

$312
Quickest round-trip

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Mon 10/5

8:12 pm-11:55 pm

1 stop3h 43m

Knoxville McGhee Tyson

Thu 10/29

10:00 am-1:31 pm

1 stop3h 31m

$319

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Tue 9/22

10:50 am-10:04 am

1 stop23h 14m

Knoxville McGhee Tyson

Wed 9/23

5:18 pm-12:14 pm

1 stop18h 56m

$323

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Mon 11/9

1:40 pm-9:40 pm

1 stop8h 00m

Knoxville McGhee Tyson

Fri 11/13

8:10 am-6:55 pm

1 stop10h 45m

$330

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Mon 11/9

6:12 am-9:45 am

1 stop3h 33m

Knoxville McGhee Tyson

Sun 11/15

6:07 pm-10:04 pm

1 stop3h 57m

$333

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Fri 11/27

5:10 am-8:49 am

1 stop3h 39m

Knoxville McGhee Tyson

Sun 12/6

8:04 pm-11:55 pm

1 stop3h 51m

$333

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Mon 11/9

1:40 pm-9:40 pm

1 stop8h 00m

Knoxville McGhee Tyson

Fri 11/13

7:25 pm-9:55 am

2 stops14h 30m

$335

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Mon 10/5

1:53 pm-5:14 pm

1 stop27h 21m

Knoxville McGhee Tyson

Thu 10/29

6:24 pm-2:02 pm

2 stops43h 38m

$339

Myrtle BeachKnoxville

MYR Myrtle Beach Intl - TYS Knoxville McGhee Tyson

MYRTYS

Myrtle Beach Intl

Fri 11/13

5:10 am-8:48 am

1 stop3h 38m

Knoxville McGhee Tyson

Fri 11/13

8:04 pm-11:55 pm

1 stop3h 51m

$347

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Myrtle Beach to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Myrtle Beach Intl to Knoxville McGhee Tyson?

Southwest is the most popular carrier operating from Myrtle Beach Intl to Knoxville McGhee Tyson

When to book flights from Myrtle Beach to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Knoxville (MYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Knoxville

Best Price Found

$207

Fastest flight time

5h 28m

Direct flights

None
The best one-way flight to Knoxville from Myrtle Beach in the past 72 hours is $207. The best round-trip flight deal from Myrtle Beach to Knoxville found on momondo in the last 72 hours is $278.
The fastest flight from Myrtle Beach to Knoxville takes 5h 28m
There are no direct flights from Myrtle Beach to Knoxville. There are no popular flight routes from Myrtle Beach to Knoxville.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Knoxville

  • How far is Myrtle Beach Intl to Knoxville McGhee Tyson by plane?

    A flight from Myrtle Beach Intl to Knoxville McGhee Tyson will travel around 325.5 mi. By plane, this route typically takes 5h 28m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Myrtle Beach to Knoxville?

Best airlines flying from Myrtle Beach to Knoxville

Compare and see reviews for airlines that fly from Myrtle Beach to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $311Free CancellationRating
7.1
12,042 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Dandridge
Clinton
Lenoir City
Rockford
Jefferson City

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Knoxville?

Once all potential Myrtle Beach to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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