Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Myrtle Beach to Knoxville from $119

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 8/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Myrtle Beach to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
7:02 pm - 11:52 pm
MYR
-
TYS
4h 50m
1 stop
Delta Logo
8:35 am - 1:33 pm
TYS
-
MYR
4h 58m
1 stop
$211Delta
Tue, Aug 18 - Tue, Aug 25
Delta Logo
7:02 pm - 11:52 pm
MYR
-
TYS
4h 50m
1 stop
Delta Logo
12:01 pm - 6:07 pm
TYS
-
MYR
6h 06m
1 stop
$237Delta
Mon, Aug 17 - Mon, Aug 24
Southwest Logo
7:50 am - 6:55 pm
MYR
-
TYS
11h 05m
2 stops
Southwest Logo
8:05 am - 1:50 pm
TYS
-
MYR
5h 45m
1 stop
$242Southwest
Wed, Aug 19 - Wed, Aug 26
Southwest Logo
7:50 am - 6:55 pm
MYR
-
TYS
11h 05m
2 stops
Southwest Logo
7:00 am - 1:50 pm
TYS
-
MYR
6h 50m
2 stops
$247Southwest
Wed, Aug 19 - Wed, Aug 26
Southwest Logo
2:25 pm - 7:50 pm
MYR
-
TYS
5h 25m
1 stop
Southwest Logo
7:00 am - 1:50 pm
TYS
-
MYR
6h 50m
2 stops
$260Southwest
Tue, Aug 18 - Tue, Aug 25
Multiple Airlines Logo
3:53 pm - 10:04 am
MYR
-
TYS
18h 11m
1 stop
Multiple Airlines Logo
3:25 pm - 7:37 pm
TYS
-
MYR
28h 12m
2 stops
$264Multiple Airlines
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
7:50 am - 6:55 pm
MYR
-
TYS
11h 05m
2 stops
Southwest Logo
7:00 am - 1:50 pm
TYS
-
MYR
6h 50m
2 stops
$265Southwest
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
8:15 am - 6:55 pm
MYR
-
TYS
10h 40m
2 stops
Southwest Logo
8:05 am - 1:50 pm
TYS
-
MYR
5h 45m
1 stop
$273Southwest
Tue, Aug 18 - Tue, Aug 25
American Airlines Logo
5:00 am - 8:32 am
MYR
-
TYS
3h 32m
1 stop
American Airlines Logo
7:58 pm - 11:58 pm
TYS
-
MYR
4h 00m
1 stop
$274American Airlines
Wed, Oct 7 - Sun, Oct 11
Southwest Logo
7:50 am - 6:55 pm
MYR
-
TYS
11h 05m
2 stops
Southwest Logo
7:00 am - 1:50 pm
TYS
-
MYR
6h 50m
2 stops
$278Southwest
Tue, Aug 18 - Tue, Aug 25

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Delta flights from Myrtle Beach to Knoxville

Our best Delta deals on Myrtle Beach to Knoxville flight tickets
Delta
Aug 18
MYR7:02 pmMyrtle Beach Intl
4h 50m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Aug 25
TYS8:35 amKnoxville McGhee Tyson
4h 58m
1 stop
MYR1:33 pmMyrtle Beach Intl
$211
Delta
Aug 17
MYR7:02 pmMyrtle Beach Intl
4h 50m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
Aug 24
TYS12:01 pmKnoxville McGhee Tyson
6h 06m
1 stop
MYR6:07 pmMyrtle Beach Intl
$237
Delta
Nov 9
MYR6:45 pmMyrtle Beach Intl
5h 01m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Nov 15
TYS5:57 pmKnoxville McGhee Tyson
5h 38m
1 stop
MYR11:35 pmMyrtle Beach Intl
$328

Southwest flights from Myrtle Beach to Knoxville

Our best Southwest deals on Myrtle Beach to Knoxville flight tickets
Southwest
Aug 19
MYR7:50 amMyrtle Beach Intl
11h 05m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
Aug 26
TYS8:05 amKnoxville McGhee Tyson
5h 45m
1 stop
MYR1:50 pmMyrtle Beach Intl
$242
Southwest
Aug 19
MYR7:50 amMyrtle Beach Intl
11h 05m
2 stops
TYS6:55 pmKnoxville McGhee Tyson
Aug 26
TYS7:00 amKnoxville McGhee Tyson
6h 50m
2 stops
MYR1:50 pmMyrtle Beach Intl
$247
Southwest
Aug 18
MYR2:25 pmMyrtle Beach Intl
5h 25m
1 stop
TYS7:50 pmKnoxville McGhee Tyson
Aug 25
TYS7:00 amKnoxville McGhee Tyson
6h 50m
2 stops
MYR1:50 pmMyrtle Beach Intl
$260

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 24, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/18

7:02 pm-11:52 pm

1 stop4h 50m

Knoxville McGhee Tyson

Tue 8/25

8:35 am-1:33 pm

1 stop4h 58m

$211

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 8/17

7:02 pm-11:52 pm

1 stop4h 50m

Knoxville McGhee Tyson

Mon 8/24

12:01 pm-6:07 pm

1 stop6h 06m

$237

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 8/19

7:50 am-6:55 pm

2 stops11h 05m

Knoxville McGhee Tyson

Wed 8/26

8:05 am-1:50 pm

1 stop5h 45m

$242

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 8/19

7:50 am-6:55 pm

2 stops11h 05m

Knoxville McGhee Tyson

Wed 8/26

7:00 am-1:50 pm

2 stops6h 50m

$247

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/18

2:25 pm-7:50 pm

1 stop5h 25m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-1:50 pm

2 stops6h 50m

$260

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/18

3:53 pm-10:04 am

1 stop18h 11m

Knoxville McGhee Tyson

Tue 8/25

3:25 pm-7:37 pm

2 stops28h 12m

$264

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/18

7:50 am-6:55 pm

2 stops11h 05m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-1:50 pm

2 stops6h 50m

$265

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/18

8:15 am-6:55 pm

2 stops10h 40m

Knoxville McGhee Tyson

Tue 8/25

8:05 am-1:50 pm

1 stop5h 45m

$273
Quickest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 10/7

5:00 am-8:32 am

1 stop3h 32m

Knoxville McGhee Tyson

Sun 10/11

7:58 pm-11:58 pm

1 stop4h 00m

$274

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 8/18

7:50 am-6:55 pm

2 stops11h 05m

Knoxville McGhee Tyson

Tue 8/25

7:00 am-1:50 pm

2 stops6h 50m

$278

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Myrtle Beach to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of July is, on average, the cheapest month to fly to Knoxville from Myrtle Beach, with most prices found around $0. If you aren’t able to travel during the month of July, then book flights to Knoxville from Myrtle Beach during April instead. Flights to Knoxville in April, while not as cheap as those in July, still average around $0.

When to book flights from Myrtle Beach to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Knoxville (MYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Knoxville

Fastest flight time

5h 01m

Direct flights

None
The fastest flight from Myrtle Beach to Knoxville takes 5h 01m
There are no direct flights from Myrtle Beach to Knoxville. There are no popular flight routes from Myrtle Beach to Knoxville.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Knoxville

  • How far is Myrtle Beach Intl to Knoxville McGhee Tyson by plane?

    A flight from Myrtle Beach Intl to Knoxville McGhee Tyson will travel around 325.5 mi. By plane, this route typically takes 5h 01m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Myrtle Beach to Knoxville?

Best airlines flying from Myrtle Beach to Knoxville

Compare and see reviews for airlines that fly from Myrtle Beach to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,843 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Maryville
Corbin
Alcoa
Murphy
Crossville
Oak Ridge
Kodak
Newport
Lenoir City
Clinton
Dandridge
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Knoxville?

Once all potential Myrtle Beach to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sun 8/23
Sun 8/30
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States