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Cheap flights from Myrtle Beach to Knoxville from $179

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 11/2. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Multiple Airlines Logo
9:05 pm - 10:33 amMYR-TYS
13h 28m1 stop
Multiple Airlines Logo
3:26 pm - 8:04 pmTYS-MYR
28h 38m1 stop
$279Multiple Airlines
Find Deal
Mon, Oct 20 - Fri, Oct 24
Multiple Airlines Logo
9:05 pm - 10:33 amMYR-TYS
13h 28m1 stop
Multiple Airlines Logo
7:02 pm - 1:03 pmTYS-MYR
42h 01m2 stops
$286Multiple Airlines
Find Deal
Mon, Oct 20 - Fri, Oct 24
Multiple Airlines Logo
6:15 am - 9:55 pmMYR-TYS
15h 40m1 stop
Multiple Airlines Logo
4:32 pm - 1:54 pmTYS-MYR
21h 22m2 stops
$304Multiple Airlines
Find Deal
Mon, Nov 3 - Wed, Nov 12
Multiple Airlines Logo
6:15 am - 8:00 pmMYR-TYS
13h 45m1 stop
Multiple Airlines Logo
4:32 pm - 1:54 pmTYS-MYR
21h 22m3 stops
$316Multiple Airlines
Find Deal
Mon, Nov 3 - Wed, Nov 12
Delta Logo
6:58 pm - 11:46 pmMYR-TYS
4h 48m1 stop
Delta Logo
8:07 pm - 11:44 pmTYS-MYR
3h 37m1 stop
$332Delta
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Sun, Nov 2 - Sun, Nov 9
Delta Logo
6:00 am - 11:07 amMYR-TYS
5h 07m1 stop
Delta Logo
5:30 am - 10:08 amTYS-MYR
4h 38m1 stop
$337Delta
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Tue, Mar 10 - Wed, Mar 11
American Airlines Logo
6:37 pm - 9:29 pmMYR-TYS
2h 52m1 stop
American Airlines Logo
8:31 pm - 11:26 pmTYS-MYR
2h 55m1 stop
$377American Airlines
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Tue, Mar 10 - Wed, Mar 11
American Airlines Logo
12:18 pm - 3:23 pmMYR-TYS
3h 05m1 stop
American Airlines Logo
5:00 am - 10:26 amTYS-MYR
5h 26m1 stop
$387American Airlines
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Tue, Oct 21 - Sat, Oct 25
United Airlines Logo
4:33 pm - 10:50 pmMYR-TYS
6h 17m1 stop
United Airlines Logo
7:00 am - 2:42 pmTYS-MYR
7h 42m1 stop
$558United Airlines
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Mon, Oct 20 - Fri, Oct 24
United Airlines Logo
5:57 pm - 10:29 amMYR-TYS
16h 32m2 stops
United Airlines Logo
7:00 am - 2:42 pmTYS-MYR
7h 42m1 stop
$579United Airlines
Find Deal
Mon, Oct 20 - Wed, Oct 22

Delta flights from Myrtle Beach to Knoxville

Our best Delta deals on Myrtle Beach to Knoxville flight tickets
Delta
Nov 2
MYR6:58 pmMyrtle Beach Intl
4h 48m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
Nov 9
TYS8:07 pmKnoxville McGhee Tyson
3h 37m
1 stop
MYR11:44 pmMyrtle Beach Intl
$332
Find similar
Delta
Mar 10
MYR6:00 amMyrtle Beach Intl
5h 07m
1 stop
TYS11:07 amKnoxville McGhee Tyson
Mar 11
TYS5:30 amKnoxville McGhee Tyson
4h 38m
1 stop
MYR10:08 amMyrtle Beach Intl
$337
Find similar
Delta
Mar 10
MYR6:00 amMyrtle Beach Intl
3h 13m
1 stop
TYS9:13 amKnoxville McGhee Tyson
Mar 11
TYS5:30 amKnoxville McGhee Tyson
4h 38m
1 stop
MYR10:08 amMyrtle Beach Intl
$357
Find similar

American Airlines flights from Myrtle Beach to Knoxville

Our best American Airlines deals on Myrtle Beach to Knoxville flight tickets
American Airlines
Mar 10
MYR6:37 pmMyrtle Beach Intl
2h 52m
1 stop
TYS9:29 pmKnoxville McGhee Tyson
Mar 11
TYS8:31 pmKnoxville McGhee Tyson
2h 55m
1 stop
MYR11:26 pmMyrtle Beach Intl
$377
Find similar
American Airlines
Oct 21
MYR12:18 pmMyrtle Beach Intl
3h 05m
1 stop
TYS3:23 pmKnoxville McGhee Tyson
Oct 25
TYS5:00 amKnoxville McGhee Tyson
5h 26m
1 stop
MYR10:26 amMyrtle Beach Intl
$387
Find similar
American Airlines
Oct 11
MYR8:20 pmMyrtle Beach Intl
3h 33m
1 stop
TYS11:53 pmKnoxville McGhee Tyson
Oct 13
TYS5:00 amKnoxville McGhee Tyson
4h 06m
1 stop
MYR9:06 amMyrtle Beach Intl
$461
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 7, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 10/20

9:05 pm-10:33 am

1 stop13h 28m

Knoxville McGhee Tyson

Fri 10/24

3:26 pm-8:04 pm

1 stop28h 38m

$279

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 10/20

9:05 pm-10:33 am

1 stop13h 28m

Knoxville McGhee Tyson

Fri 10/24

7:02 pm-1:03 pm

2 stops42h 01m

$286

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 11/3

6:15 am-9:55 pm

1 stop15h 40m

Knoxville McGhee Tyson

Wed 11/12

4:32 pm-1:54 pm

2 stops21h 22m

$304

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 11/3

6:15 am-8:00 pm

1 stop13h 45m

Knoxville McGhee Tyson

Wed 11/12

4:32 pm-1:54 pm

3 stops21h 22m

$316

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sun 11/2

6:58 pm-11:46 pm

1 stop4h 48m

Knoxville McGhee Tyson

Sun 11/9

8:07 pm-11:44 pm

1 stop3h 37m

$332

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 3/10

6:00 am-11:07 am

1 stop5h 07m

Knoxville McGhee Tyson

Wed 3/11

5:30 am-10:08 am

1 stop4h 38m

$337

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 3/10

6:37 pm-9:29 pm

1 stop2h 52m

Knoxville McGhee Tyson

Wed 3/11

8:31 pm-11:26 pm

1 stop2h 55m

$377

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 10/21

12:18 pm-3:23 pm

1 stop3h 05m

Knoxville McGhee Tyson

Sat 10/25

5:00 am-10:26 am

1 stop5h 26m

$387

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 10/20

4:33 pm-10:50 pm

1 stop6h 17m

Knoxville McGhee Tyson

Fri 10/24

7:00 am-2:42 pm

1 stop7h 42m

$558

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Mon 10/20

5:57 pm-10:29 am

2 stops16h 32m

Knoxville McGhee Tyson

Wed 10/22

7:00 am-2:42 pm

1 stop7h 42m

$579

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Myrtle Beach to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Myrtle Beach, with most prices found around $228. If you aren’t able to travel during the month of September, then book flights to Knoxville from Myrtle Beach during March instead. Flights to Knoxville in March, while not as cheap as those in September, still average around $278.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Myrtle Beach to Knoxville is on a Tuesday. Travelers who choose to depart for Knoxville on a Tuesday will often find tickets for as low as $283. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Myrtle Beach to Knoxville for around $598.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Myrtle Beach to Knoxville when you can find flight prices for as low as $338. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $479.

When to book flights from Myrtle Beach to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Knoxville (MYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Knoxville

Direct flights

None
There are no direct flights from Myrtle Beach to Knoxville. There are no popular flight routes from Myrtle Beach to Knoxville.
Search flight deals

  • How far is Myrtle Beach Intl to Knoxville McGhee Tyson by plane?

    A flight from Myrtle Beach Intl to Knoxville McGhee Tyson will travel around 325.5 mi. By plane, this route typically takes 2h 52m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Myrtle Beach to Knoxville?

Best airlines flying from Myrtle Beach to Knoxville

Compare and see reviews for airlines that fly from Myrtle Beach to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $198Free CancellationRating
7.9
7,969 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,041 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Knoxville?

Once all potential Myrtle Beach to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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