Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Myrtle Beach to Knoxville from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Myrtle Beach to Knoxville departing on 6/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Myrtle Beach to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
1:30 pm - 5:11 pm
MYR
-
TYS
3h 41m
1 stop
Delta Logo
5:40 am - 10:44 am
TYS
-
MYR
5h 04m
1 stop
$279Delta
Wed, Jun 3 - Wed, Jun 10
Delta Logo
6:00 am - 11:09 am
MYR
-
TYS
5h 09m
1 stop
Delta Logo
11:55 am - 3:29 pm
TYS
-
MYR
3h 34m
1 stop
$295Delta
Wed, Jun 3 - Wed, Jun 10
Southwest Logo
2:10 pm - 9:15 pm
MYR
-
TYS
7h 05m
1 stop
Southwest Logo
8:10 am - 6:25 pm
TYS
-
MYR
10h 15m
1 stop
$300Southwest
Tue, Jun 30 - Tue, Jul 7
Delta Logo
4:07 pm - 8:32 pm
MYR
-
TYS
4h 25m
1 stop
Delta Logo
7:35 am - 10:44 am
TYS
-
MYR
3h 09m
1 stop
$305Delta
Wed, Jun 3 - Wed, Jun 10
Southwest Logo
10:25 am - 9:15 pm
MYR
-
TYS
10h 50m
2 stops
Southwest Logo
8:10 am - 6:25 pm
TYS
-
MYR
10h 15m
1 stop
$306Southwest
Tue, Jun 30 - Tue, Jul 7
Multiple Airlines Logo
3:17 pm - 8:30 pm
MYR
-
TYS
29h 13m
2 stops
Multiple Airlines Logo
1:02 pm - 7:37 pm
TYS
-
MYR
6h 35m
1 stop
$314Multiple Airlines
Wed, Jun 3 - Wed, Jun 10
American Airlines Logo
5:31 am - 8:22 am
MYR
-
TYS
2h 51m
1 stop
American Airlines Logo
5:08 am - 8:03 am
TYS
-
MYR
2h 55m
1 stop
$316American Airlines
Fri, Oct 23 - Wed, Oct 28
Multiple Airlines Logo
9:53 pm - 2:16 pm
MYR
-
TYS
40h 23m
2 stops
Multiple Airlines Logo
8:40 pm - 5:45 pm
TYS
-
MYR
21h 05m
1 stop
$317Multiple Airlines
Sat, Jul 4 - Sat, Jul 11
Delta Logo
7:55 pm - 11:56 pm
MYR
-
TYS
4h 01m
1 stop
Delta Logo
7:46 pm - 11:59 pm
TYS
-
MYR
4h 13m
1 stop
$318Delta
Thu, Jun 4 - Thu, Jun 11
American Airlines Logo
8:41 pm - 11:30 pm
MYR
-
TYS
2h 49m
1 stop
American Airlines Logo
7:13 am - 10:11 am
TYS
-
MYR
2h 58m
1 stop
$321American Airlines
Sat, Oct 17 - Thu, Oct 22

Delta flights from Myrtle Beach to Knoxville

Our best Delta deals on Myrtle Beach to Knoxville flight tickets
Delta
Jun 3
MYR1:30 pmMyrtle Beach Intl
3h 41m
1 stop
TYS5:11 pmKnoxville McGhee Tyson
Jun 10
TYS5:40 amKnoxville McGhee Tyson
5h 04m
1 stop
MYR10:44 amMyrtle Beach Intl
$279
Delta
Jun 3
MYR6:00 amMyrtle Beach Intl
5h 09m
1 stop
TYS11:09 amKnoxville McGhee Tyson
Jun 10
TYS11:55 amKnoxville McGhee Tyson
3h 34m
1 stop
MYR3:29 pmMyrtle Beach Intl
$295
Delta
Jun 3
MYR4:07 pmMyrtle Beach Intl
4h 25m
1 stop
TYS8:32 pmKnoxville McGhee Tyson
Jun 10
TYS7:35 amKnoxville McGhee Tyson
3h 09m
1 stop
MYR10:44 amMyrtle Beach Intl
$305

American Airlines flights from Myrtle Beach to Knoxville

Our best American Airlines deals on Myrtle Beach to Knoxville flight tickets
American Airlines
Oct 23
MYR5:31 amMyrtle Beach Intl
2h 51m
1 stop
TYS8:22 amKnoxville McGhee Tyson
Oct 28
TYS5:08 amKnoxville McGhee Tyson
2h 55m
1 stop
MYR8:03 amMyrtle Beach Intl
$316
American Airlines
May 21
MYR8:41 pmMyrtle Beach Intl
3h 06m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
May 25
TYS5:00 amKnoxville McGhee Tyson
3h 41m
1 stop
MYR8:41 amMyrtle Beach Intl
$437
American Airlines
May 21
MYR6:06 pmMyrtle Beach Intl
3h 52m
1 stop
TYS9:58 pmKnoxville McGhee Tyson
May 24
TYS6:07 pmKnoxville McGhee Tyson
3h 40m
1 stop
MYR9:47 pmMyrtle Beach Intl
$498

momondo Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 9, 2026.
Use the filters below to find and compare flights from Myrtle Beach to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 6/3

1:30 pm-5:11 pm

1 stop3h 41m

Knoxville McGhee Tyson

Wed 6/10

5:40 am-10:44 am

1 stop5h 04m

$279

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 6/3

6:00 am-11:09 am

1 stop5h 09m

Knoxville McGhee Tyson

Wed 6/10

11:55 am-3:29 pm

1 stop3h 34m

$295

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 6/30

2:10 pm-9:15 pm

1 stop7h 05m

Knoxville McGhee Tyson

Tue 7/7

8:10 am-6:25 pm

1 stop10h 15m

$300

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 6/3

4:07 pm-8:32 pm

1 stop4h 25m

Knoxville McGhee Tyson

Wed 6/10

7:35 am-10:44 am

1 stop3h 09m

$305

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Tue 6/30

10:25 am-9:15 pm

2 stops10h 50m

Knoxville McGhee Tyson

Tue 7/7

8:10 am-6:25 pm

1 stop10h 15m

$306

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Wed 6/3

3:17 pm-8:30 pm

2 stops29h 13m

Knoxville McGhee Tyson

Wed 6/10

1:02 pm-7:37 pm

1 stop6h 35m

$314
Quickest round-trip

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Fri 10/23

5:31 am-8:22 am

1 stop2h 51m

Knoxville McGhee Tyson

Wed 10/28

5:08 am-8:03 am

1 stop2h 55m

$316

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 7/4

9:53 pm-2:16 pm

2 stops40h 23m

Knoxville McGhee Tyson

Sat 7/11

8:40 pm-5:45 pm

1 stop21h 05m

$317

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Thu 6/4

7:55 pm-11:56 pm

1 stop4h 01m

Knoxville McGhee Tyson

Thu 6/11

7:46 pm-11:59 pm

1 stop4h 13m

$318

Myrtle BeachKnoxville

MYR - TYS

MYRTYS

Myrtle Beach Intl

Sat 10/17

8:41 pm-11:30 pm

1 stop2h 49m

Knoxville McGhee Tyson

Thu 10/22

7:13 am-10:11 am

1 stop2h 58m

$321

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Myrtle Beach to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Myrtle Beach and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of September is, on average, the cheapest month to fly to Knoxville from Myrtle Beach, with most prices found around $228. If you aren’t able to travel during the month of September, then book flights to Knoxville from Myrtle Beach during July instead. Flights to Knoxville in July, while not as cheap as those in September, still average around $296.

When to book flights from Myrtle Beach to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Myrtle Beach to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Myrtle Beach to Knoxville (MYR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Myrtle Beach to Knoxville

Fastest flight time

3h 57m

Direct flights

None
The fastest flight from Myrtle Beach to Knoxville takes 3h 57m
There are no direct flights from Myrtle Beach to Knoxville. There are no popular flight routes from Myrtle Beach to Knoxville.
Search flight deals

Frequently asked questions about flying from Myrtle Beach to Knoxville

  • How far is Myrtle Beach Intl to Knoxville McGhee Tyson by plane?

    A flight from Myrtle Beach Intl to Knoxville McGhee Tyson will travel around 325.5 mi. By plane, this route typically takes 3h 57m.

  • When did momondo last update prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Myrtle Beach Intl Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Myrtle Beach to Knoxville?

Best airlines flying from Myrtle Beach to Knoxville

Compare and see reviews for airlines that fly from Myrtle Beach to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $283Free CancellationRating
7.1
11,668 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Alcoa
Corbin
Crossville
Maryville
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Myrtle Beach to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Myrtle Beach to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Myrtle Beach to Knoxville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Knoxville from Myrtle Beach which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Myrtle Beach to Knoxville?

Once all potential Myrtle Beach to Knoxville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Myrtle Beach to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Myrtle Beach to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Mon 6/8
Mon 6/15
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States