How many flights depart from Missouri to South Carolina on average per week?

As of December 2025, there are 91 flights per week flying from Missouri to South Carolina. The most common day of the week flights depart is Thu, with 21% of flights taking off on this day.

How long is the flight from Missouri to South Carolina?

Flight times vary depending on what airport in Missouri you fly out of and what airport in South Carolina you fly into. For example, flying from St. Louis to Charleston takes 1h 55m on average. On the other hand, flying from Springfield to Charleston takes 4h 14m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

What is the cheapest airline that flies from Missouri to South Carolina?

Frontier, Spirit Airlines, and Delta are the most popular carriers operating from Missouri to South Carolina

What airlines fly to South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to South Carolina from Missouri according to our data. American Airlines is the first choice among our users, with 50% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Missouri to South Carolina?

Prices for flights from Missouri to South Carolina refresh daily.

How many operators does momondo search for flights from Missouri to South Carolina?

As of December 2025, there are 6 operators available to choose from for flights from Missouri to South Carolina.

How old do you have to be to fly from Missouri to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$64 Cheap Flights from Missouri to South Carolina in 2025/26

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Find the cheapest flights from Missouri to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

11:18 am - 6:07 pm

STL

CLT

5h 49m1 stop

7:06 pm - 11:33 pm

CLT

STL

5h 27m1 stop

$128Frontier

Fri, Jan 23 - Fri, Jan 30

5:11 pm - 3:37 pm

STL

CLT

21h 26m1 stop

11:35 am - 11:33 pm

CLT

STL

12h 58m1 stop

$130Frontier

Tue, Jan 6 - Wed, Jan 21

11:26 am - 5:36 pm

MCI

CHS

29h 10m1 stop

6:35 pm - 10:31 am

CHS

MCI

16h 56m1 stop

$158Spirit Airlines

Thu, Feb 5 - Sun, Feb 8

11:26 am - 12:40 am

MCI

CLT

12h 14m1 stop

7:43 pm - 10:31 am

CLT

MCI

15h 48m1 stop

$170Spirit Airlines

Mon, Jan 19 - Wed, Jan 21

12:00 pm - 7:25 pm

STL

CAE

6h 25m1 stop

10:15 am - 3:56 pm

CAE

STL

6h 41m1 stop

$204Delta

Sat, Jan 17 - Sat, Jan 24

11:45 am - 8:36 pm

STL

CAE

7h 51m1 stop

6:28 pm - 11:02 pm

CAE

STL

5h 34m1 stop

$211American Airlines

Wed, Feb 18 - Sat, Feb 21

9:59 am - 6:57 pm

STL

CAE

7h 58m2 stops

6:28 pm - 11:02 pm

CAE

STL

5h 34m1 stop

$216American Airlines

Wed, Feb 18 - Sat, Feb 21

12:00 pm - 6:52 pm

STL

SAV

5h 52m1 stop

2:53 pm - 5:50 pm

SAV

STL

3h 57m1 stop

$237Delta

Thu, Jan 29 - Sun, Feb 1

1:40 pm - 8:50 pm

STL

SAV

6h 10m1 stop

6:05 am - 9:10 am

SAV

STL

4h 05m1 stop

$288Southwest

Thu, Feb 19 - Sun, Feb 22

6:15 am - 3:20 pm

MCI

SAV

8h 05m2 stops

5:25 pm - 8:40 pm

SAV

MCI

4h 15m1 stop

$294Southwest

Tue, Jan 13 - Sat, Jan 17

United Airlines flights from Missouri to South Carolina

Our best United Airlines deals on Missouri to South Carolina flight tickets

United Airlines

Jan 14

SGF3:14 pmSpringfield-Branson

5h 23m

1 stop

CLT9:37 pmCharlotte Douglas

Jan 21

CLT5:35 pmCharlotte Douglas

5h 23m

1 stop

SGF9:58 pmSpringfield-Branson

$267

Find similar

United Airlines

Jan 14

SGF7:45 amSpringfield-Branson

12h 31m

2 stops

CLT9:16 pmCharlotte Douglas

Jan 21

CLT5:35 pmCharlotte Douglas

5h 23m

1 stop

SGF9:58 pmSpringfield-Branson

$272

Find similar

United Airlines

Jan 9

SGF3:14 pmSpringfield-Branson

5h 23m

1 stop

CLT9:37 pmCharlotte Douglas

Jan 16

CLT11:26 amCharlotte Douglas

6h 01m

1 stop

SGF4:27 pmSpringfield-Branson

$277

Find similar

American Airlines flights from Missouri to South Carolina

Our best American Airlines deals on Missouri to South Carolina flight tickets

American Airlines

Feb 18

STL2:00 pmLambert-St Louis

6h 28m

1 stop

CAE9:28 pmColumbia Metropolitan

Feb 21

CAE6:28 pmColumbia Metropolitan

5h 34m

1 stop

STL11:02 pmLambert-St Louis

$211

Find similar

American Airlines

Feb 18

STL2:00 pmLambert-St Louis

6h 28m

1 stop

CAE9:28 pmColumbia Metropolitan

Feb 21

CAE4:12 pmColumbia Metropolitan

7h 50m

2 stops

STL11:02 pmLambert-St Louis

$216

Find similar

American Airlines

Feb 18

STL9:59 amLambert-St Louis

7h 58m

2 stops

CAE6:57 pmColumbia Metropolitan

Feb 21

CAE4:12 pmColumbia Metropolitan

7h 50m

2 stops

STL11:02 pmLambert-St Louis

$221

Find similar

Fly from

Fly to

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 1/23

11:18 am-6:07 pm

1 stop5h 49m

Charlotte Douglas

Fri 1/30

7:06 pm-11:33 pm

1 stop5h 27m

$128

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 1/6

5:11 pm-3:37 pm

1 stop21h 26m

Charlotte Douglas

Wed 1/21

11:35 am-11:33 pm

1 stop12h 58m

$130

Kansas CityCharleston

MCI - CHS

MCICHS

Kansas City

Thu 2/5

11:26 am-5:36 pm

1 stop29h 10m

Charleston

Sun 2/8

6:35 pm-10:31 am

1 stop16h 56m

$158

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Mon 1/19

11:26 am-12:40 am

1 stop12h 14m

Charlotte Douglas

Wed 1/21

7:43 pm-10:31 am

1 stop15h 48m

$170

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Sat 1/17

12:00 pm-7:25 pm

1 stop6h 25m

Columbia Metropolitan

Sat 1/24

10:15 am-3:56 pm

1 stop6h 41m

$204

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 2/18

11:45 am-8:36 pm

1 stop7h 51m

Columbia Metropolitan

Sat 2/21

6:28 pm-11:02 pm

1 stop5h 34m

$211

St. LouisColumbia

STL - CAE

STLCAE

Lambert-St Louis

Wed 2/18

9:59 am-6:57 pm

2 stops7h 58m

Columbia Metropolitan

Sat 2/21

6:28 pm-11:02 pm

1 stop5h 34m

$216

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Thu 1/29

12:00 pm-6:52 pm

1 stop5h 52m

Savannah/Hilton Head

Sun 2/1

2:53 pm-5:50 pm

1 stop3h 57m

$237

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Thu 2/19

1:40 pm-8:50 pm

1 stop6h 10m

Savannah/Hilton Head

Sun 2/22

6:05 am-9:10 am

1 stop4h 05m

$288

Kansas CitySavannah

MCI - SAV

MCISAV

Kansas City

Tue 1/13

6:15 am-3:20 pm

2 stops8h 05m

Savannah/Hilton Head

Sat 1/17

5:25 pm-8:40 pm

1 stop4h 15m

$294

Flights are sorted by cheapest round-trip flights first.

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How to get the cheapest flight ticket from Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Missouri is in August. Flight prices, which tend to average around $319, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Missouri during November instead. Flights to South Carolina in November, while not as cheap as those in August, still average around $328.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $488.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Missouri to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $387. Try not to purchase tickets in the afternoon because they tend to be around $456. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to South Carolina flight route?

Fly from Lambert-St Louis to Myrtle Beach Intl for the best Missouri - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $390 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Missouri for as low as $336 on momondo.

What cabin class options are available on Missouri to South Carolina flights?

There is only 1 cabin class available to choose from on Missouri to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Missouri to South Carolina.

Cheap Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South Carolina

Fastest flight time	1h 45m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Missouri to South Carolina takes 1h 45m

Direct flights go from Missouri to South Carolina every day.

There are 57 airports in South Carolina. From Missouri there are direct flights to Savannah/Hilton Head (SAV), Charlotte Douglas (CLT), Charleston (CHS).

Search flight deals

When did momondo last update prices for flights from Missouri to South Carolina?
Prices for flights from Missouri to South Carolina refresh daily.
How many operators does momondo search for flights from Missouri to South Carolina?
As of December 2025, there are 6 operators available to choose from for flights from Missouri to South Carolina.
How old do you have to be to fly from Missouri to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Missouri to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Missouri to South Carolina is Boeing 737 MAX 8, representing 40.91% of all bookings. The subsequent popular models are Boeing 737-800 Passenger/BBJ2 (winglets) at 31.82%, Boeing 737-700 Passenger/BBJ1 (winglets) at 22.73%, and Airbus A220-300 at 4.55%.

Best airlines flying from Missouri to South Carolina

Compare and see reviews for airlines that fly from Missouri to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $84	Free Cancellation	Rating 6.3 8,179 reviews	Search Spirit Airlines flights
Delta	PriceFrom $150	Free Cancellation	Rating 7.9 8,008 reviews	Search Delta flights
American Airlines	PriceFrom $204	Free Cancellation	Rating 7.2 11,050 reviews	Search American Airlines flights
Southwest	PriceFrom $237	Free Cancellation	Rating 7.9 4,253 reviews	Search Southwest flights
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 9,095 reviews	Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South Carolina?

Finding the right flight to South Carolina from Missouri is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Missouri to South Carolina with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South Carolina from Missouri with this policy.

How can momondo help me find flights from Missouri to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Missouri.

I’m not ready to book a flight from Missouri to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Find better results for your trip to South Carolina

Popular cities in South Carolina

Flights to New Yorkfrom $34

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Flights to Chicagofrom $49

Flights to Orlandofrom $41

Flights to San Franciscofrom $53

Flights to Las Vegasfrom $40

Flights to Washington, D.C.from $49

Flights to Bostonfrom $55

Flights to Atlantafrom $49

Flights to Dallasfrom $52

Flights to Seattlefrom $58

Cheap flights from Missouri to South Carolina from $64

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to South Carolina departing on 2/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Missouri to South Carolina

Cheap round-trip flights

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Cheap last minute flights

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United Airlines flights from Missouri to South Carolina

Our best United Airlines deals on Missouri to South Carolina flight tickets

American Airlines flights from Missouri to South Carolina

Our best American Airlines deals on Missouri to South Carolina flight tickets

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Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

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How to get the cheapest flight ticket from Missouri to South Carolina

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $488.

What is the cheapest time of day to depart on your flight to South Carolina?

What is the cheapest Missouri to South Carolina flight route?

Fly from Lambert-St Louis to Myrtle Beach Intl for the best Missouri - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

What cabin class options are available on Missouri to South Carolina flights?

There is only 1 cabin class available to choose from on Missouri to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Missouri to South Carolina.

What is the cheapest airline that flies from Missouri to South Carolina?

Frontier, Spirit Airlines, and Delta are the most popular carriers operating from Missouri to South Carolina

What airlines fly to South Carolina?

How many flights depart from Missouri to South Carolina on average per week?

As of December 2025, there are 91 flights per week flying from Missouri to South Carolina. The most common day of the week flights depart is Thu, with 21% of flights taking off on this day.

How long is the flight from Missouri to South Carolina?

Cheap Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South Carolina

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Missouri to South Carolina?

How many operators does momondo search for flights from Missouri to South Carolina?

How old do you have to be to fly from Missouri to South Carolina?

What documentation or ID do you need to fly to South Carolina?

What is the most popular plane model from Missouri to South Carolina?

Best airlines flying from Missouri to South Carolina

Compare and see reviews for airlines that fly from Missouri to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South Carolina?

Can I find flights from Missouri to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Missouri to South Carolina?

I’m not ready to book a flight from Missouri to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo