How many flights depart from Missouri to South Carolina on average per day?

As of September 2025, there are 15 flights per day flying from Missouri to South Carolina. The most common time of day flights depart is 7:00AM, with 83% of flights taking off at noon.

What airlines fly to South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to South Carolina from Missouri according to our data. American Airlines is the first choice among our users, with 49% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many flights depart from Missouri to South Carolina on average per week?

As of September 2025, there are 109 flights per week flying from Missouri to South Carolina. The most common day of the week flights depart is Thu, with 18% of flights taking off on this day.

What is the cheapest airline that flies from Missouri to South Carolina?

Frontier, Spirit Airlines, and Southwest are the most popular carriers operating from Missouri to South Carolina

How long is the flight from Missouri to South Carolina?

Flight times vary depending on what airport in Missouri you fly out of and what airport in South Carolina you fly into. For example, flying from St. Louis to Charleston takes 1h 55m on average. On the other hand, flying from Kansas City to Charleston takes 4h 03m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

When did momondo last update prices for flights from Missouri to South Carolina?

Prices for flights from Missouri to South Carolina refresh daily.

How many operators does momondo search for flights from Missouri to South Carolina?

As of September 2025, there are 6 operators available to choose from for flights from Missouri to South Carolina.

How old do you have to be to fly from Missouri to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$78 Cheap Flights from Missouri to South Carolina in 2025/26

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Find the cheapest flights from Missouri to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

2:12 pm - 12:23 pmSTL-CLT

21h 11m1 stop

6:07 pm - 9:07 amCLT-STL

16h 00m1 stop

$156Frontier

Find Deal

Fri, Oct 31 - Sun, Nov 2

9:32 pm - 1:01 pmSTL-CLT

14h 29m1 stop

5:20 pm - 9:07 amCLT-STL

16h 47m1 stop

$164Frontier

Find Deal

Fri, Oct 3 - Mon, Oct 6

5:56 pm - 8:52 pmSTL-CLT

1h 56mnonstop

7:05 am - 8:24 amCLT-STL

2h 19mnonstop

$197American Airlines

Find Deal

Tue, Dec 2 - Sat, Dec 6

12:13 pm - 12:59 amMCI-CLT

11h 46m1 stop

5:45 am - 11:08 amCLT-MCI

6h 23m1 stop

$216Spirit Airlines

Find Deal

Fri, Nov 7 - Mon, Nov 10

8:30 am - 11:25 amSTL-CLT

1h 55mnonstop

5:23 pm - 6:25 pmCLT-STL

2h 02mnonstop

$217American Airlines

Find Deal

Wed, Oct 22 - Wed, Nov 12

12:20 pm - 12:59 amSTL-CLT

11h 39m1 stop

5:06 pm - 11:01 amCLT-STL

18h 55m1 stop

$219Spirit Airlines

Find Deal

Thu, Dec 11 - Wed, Dec 17

2:55 pm - 5:40 pmSTL-CLT

1h 45mnonstop

6:55 pm - 11:10 pmCLT-STL

5h 15m1 stop

$227Southwest

Find Deal

Thu, Dec 11 - Thu, Dec 18

2:55 pm - 5:40 pmSTL-CLT

1h 45mnonstop

12:50 pm - 9:30 pmCLT-STL

9h 40m2 stops

$232Southwest

Find Deal

Thu, Dec 11 - Thu, Dec 18

6:40 am - 11:58 amSTL-CLT

4h 18m1 stop

5:27 am - 8:25 amCLT-STL

3h 58m1 stop

$237Delta

Find Deal

Tue, Nov 25 - Tue, Dec 2

6:15 am - 12:11 pmMCI-CLT

4h 56m1 stop

5:45 am - 11:29 amCLT-MCI

6h 44m1 stop

$237Delta

Find Deal

Tue, Oct 28 - Sun, Nov 2

Frontier flights from Missouri to South Carolina

Our best Frontier deals on Missouri to South Carolina flight tickets

Frontier

Oct 31

STL2:12 pmLambert-St Louis

21h 11m

1 stop

CLT12:23 pmCharlotte Douglas

Nov 2

CLT6:07 pmCharlotte Douglas

16h 00m

1 stop

STL9:07 amLambert-St Louis

$156

Find similar

Frontier

Oct 3

STL9:32 pmLambert-St Louis

14h 29m

1 stop

CLT1:01 pmCharlotte Douglas

Oct 6

CLT5:20 pmCharlotte Douglas

16h 47m

1 stop

STL9:07 amLambert-St Louis

$164

Find similar

Frontier

Sep 27

STL7:55 pmLambert-St Louis

19h 30m

1 stop

CLT4:25 pmCharlotte Douglas

Sep 28

CLT8:51 pmCharlotte Douglas

17h 11m

1 stop

STL1:02 pmLambert-St Louis

$172

Find similar

American Airlines flights from Missouri to South Carolina

Our best American Airlines deals on Missouri to South Carolina flight tickets

American Airlines

Dec 2

STL5:56 pmLambert-St Louis

1h 56m

CLT8:52 pmCharlotte Douglas

Dec 6

CLT7:05 amCharlotte Douglas

2h 19m

STL8:24 amLambert-St Louis

$197

Find similar

American Airlines

Oct 22

STL8:30 amLambert-St Louis

1h 55m

CLT11:25 amCharlotte Douglas

Nov 12

CLT5:23 pmCharlotte Douglas

2h 02m

STL6:25 pmLambert-St Louis

$217

Find similar

American Airlines

Nov 4

STL6:04 pmLambert-St Louis

1h 56m

CLT9:00 pmCharlotte Douglas

Nov 9

CLT4:51 pmCharlotte Douglas

2h 03m

STL5:54 pmLambert-St Louis

$230

Find similar

Fly from

Fly to

Route

Depart

Return

Price

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 10/31

2:12 pm-12:23 pm

1 stop21h 11m

Charlotte Douglas

Sun 11/2

6:07 pm-9:07 am

1 stop16h 00m

$156

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Fri 10/3

9:32 pm-1:01 pm

1 stop14h 29m

Charlotte Douglas

Mon 10/6

5:20 pm-9:07 am

1 stop16h 47m

$164

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 12/2

5:56 pm-8:52 pm

Nonstop1h 56m

Charlotte Douglas

Sat 12/6

7:05 am-8:24 am

Nonstop2h 19m

$197

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Fri 11/7

12:13 pm-12:59 am

1 stop11h 46m

Charlotte Douglas

Mon 11/10

5:45 am-11:08 am

1 stop6h 23m

$216

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 10/22

8:30 am-11:25 am

Nonstop1h 55m

Charlotte Douglas

Wed 11/12

5:23 pm-6:25 pm

Nonstop2h 02m

$217

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 12/11

12:20 pm-12:59 am

1 stop11h 39m

Charlotte Douglas

Wed 12/17

5:06 pm-11:01 am

1 stop18h 55m

$219

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 12/11

2:55 pm-5:40 pm

Nonstop1h 45m

Charlotte Douglas

Thu 12/18

6:55 pm-11:10 pm

1 stop5h 15m

$227

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Thu 12/11

2:55 pm-5:40 pm

Nonstop1h 45m

Charlotte Douglas

Thu 12/18

12:50 pm-9:30 pm

2 stops9h 40m

$232

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Tue 11/25

6:40 am-11:58 am

1 stop4h 18m

Charlotte Douglas

Tue 12/2

5:27 am-8:25 am

1 stop3h 58m

$237

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Tue 10/28

6:15 am-12:11 pm

1 stop4h 56m

Charlotte Douglas

Sun 11/2

5:45 am-11:29 am

1 stop6h 44m

$237

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Missouri is in August. Flight prices, which tend to average around $320, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Missouri during October instead. Flights to South Carolina in October, while not as cheap as those in August, still average around $372.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $544.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Missouri to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $387. Try not to purchase tickets in the afternoon because they tend to be around $456. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to South Carolina flight route?

Fly from Lambert-St Louis to Charleston for the best Missouri - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $392 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Missouri for as low as $328 on momondo.

What cabin class options are available on Missouri to South Carolina flights?

There is only 1 cabin class available to choose from on Missouri to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to South Carolina flights?

You could potentially save up to 30% on your flight if you consider stops on a Missouri to South Carolina flight.

Cheap Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South Carolina

Best Price Found	$389
Fastest flight time	1h 45m
Direct flights	Every day
Airports in South Carolina	2 airports

The best flight deal from Missouri to South Carolina found on momondo in the last 72 hours is $389

The fastest flight from Missouri to South Carolina takes 1h 45m

Direct flights go from Missouri to South Carolina every day.

There are 2 airports near South Carolina: Charlotte Douglas (CLT), Charleston (CHS)

Search flight deals

When did momondo last update prices for flights from Missouri to South Carolina?
Prices for flights from Missouri to South Carolina refresh daily.
How many operators does momondo search for flights from Missouri to South Carolina?
As of September 2025, there are 6 operators available to choose from for flights from Missouri to South Carolina.
How old do you have to be to fly from Missouri to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Missouri to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Missouri to South Carolina is Boeing 737-700 Passenger/BBJ1 (winglets), representing 36.36% of all bookings. The subsequent popular models are Boeing 737 MAX 8 at 30.30%, Boeing 737-800 Passenger/BBJ2 (winglets) at 30.30%, and Airbus A220-300 at 3.03%.

Best airlines flying from Missouri to South Carolina

Compare and see reviews for airlines that fly from Missouri to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $99	Free Cancellation	Rating 6.3 8,031 reviews	Search Spirit Airlines flights
Delta	PriceFrom $150	Free Cancellation	Rating 7.9 7,971 reviews	Search Delta flights
American Airlines	PriceFrom $204	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $223	Free Cancellation	Rating 7.4 8,922 reviews	Search United Airlines flights
Southwest	PriceFrom $237	Free Cancellation	Rating 8.0 4,244 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South Carolina?

Finding the right flight to South Carolina from Missouri is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Missouri to South Carolina with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South Carolina from Missouri with this policy.

How can momondo help me find flights from Missouri to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Missouri.

I’m not ready to book a flight from Missouri to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Popular cities in South Carolina

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Cheap flights from Missouri to South Carolina from $78

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to South Carolina departing on 1/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

Big names and deals

Big names and deals

Filter for what you want

Filter for what you want

Trusted and free

Trusted and free

Price Alerts

Price Alerts

Find the cheapest flights from Missouri to South Carolina

Cheap round-trip flights

Cheap one-way flights

Cheap last minute flights

Cheap direct flights

Frontier flights from Missouri to South Carolina

Our best Frontier deals on Missouri to South Carolina flight tickets

American Airlines flights from Missouri to South Carolina

Our best American Airlines deals on Missouri to South Carolina flight tickets

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Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.

See travel insights to South Carolina from

How to get the cheapest flight ticket from Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $544.

What is the cheapest time of day to depart on your flight to South Carolina?

What is the cheapest Missouri to South Carolina flight route?

Fly from Lambert-St Louis to Charleston for the best Missouri - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

What cabin class options are available on Missouri to South Carolina flights?

There is only 1 cabin class available to choose from on Missouri to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to South Carolina flights?

You could potentially save up to 30% on your flight if you consider stops on a Missouri to South Carolina flight.

What is the cheapest airline that flies from Missouri to South Carolina?

Frontier, Spirit Airlines, and Southwest are the most popular carriers operating from Missouri to South Carolina

What airlines fly to South Carolina?

How many flights depart from Missouri to South Carolina on average per day?

As of September 2025, there are 15 flights per day flying from Missouri to South Carolina. The most common time of day flights depart is 7:00AM, with 83% of flights taking off at noon.

How many flights depart from Missouri to South Carolina on average per week?

As of September 2025, there are 109 flights per week flying from Missouri to South Carolina. The most common day of the week flights depart is Thu, with 18% of flights taking off on this day.

How long is the flight from Missouri to South Carolina?

Cheap Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Missouri to South Carolina?

How many operators does momondo search for flights from Missouri to South Carolina?

How old do you have to be to fly from Missouri to South Carolina?

What documentation or ID do you need to fly to South Carolina?

What is the most popular plane model from Missouri to South Carolina?

Best airlines flying from Missouri to South Carolina

Compare and see reviews for airlines that fly from Missouri to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South Carolina?

Can I find flights from Missouri to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Missouri to South Carolina?

I’m not ready to book a flight from Missouri to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo