Cheap flights from Missouri to South Carolina from $78

The cheapest month to fly to South Carolina from Missouri is in August. Flight prices, which tend to average around $319, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Missouri during November instead. Flights to South Carolina in November, while not as cheap as those in August, still average around $328.

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $353. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $487.

Our data shows that the cheapest Missouri to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $364. Try not to purchase tickets at noon because they tend to be around $447. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Lambert-St Louis to Myrtle Beach Intl for the best Missouri - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $381 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Missouri for as low as $294 on momondo.

There is only 1 cabin class available to choose from on Missouri to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, Spirit Airlines, and Southwest are the most popular carriers operating from Missouri to South Carolina

American Airlines, Delta and Southwest are the top three most popular airlines that fly to South Carolina from Missouri according to our data. American Airlines is the first choice among our users, with 47% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of March 2026, there are 6 flights per day flying from Missouri to South Carolina. The most common time of day flights depart is 2:00PM, with 100% of flights taking off in the afternoon.

As of March 2026, there are 42 flights per week flying from Missouri to South Carolina. The most common day of the week flights depart is Wed, with 36% of flights taking off on this day.