What is the cheapest airline that flies from Missouri to South Carolina?

American Airlines, Delta, and Southwest are the most popular carriers operating from Missouri to South Carolina

What airlines fly to South Carolina?

American Airlines, Delta and Southwest are the top three most popular airlines that fly to South Carolina from Missouri according to our data. American Airlines is the first choice among our users, with 46% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many flights depart from Missouri to South Carolina on average per week?

As of June 2026, there are 116 flights per week flying from Missouri to South Carolina. The most common day of the week flights depart is Mon, with 18% of flights taking off on this day.

How long is the flight from Missouri to South Carolina?

Flight times vary depending on what airport in Missouri you fly out of and what airport in South Carolina you fly into. For example, flying from St. Louis to Charleston takes 1h 55m on average. On the other hand, flying from Kansas City to Charleston takes 2h 25m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

How many flights depart from Missouri to South Carolina on average per day?

As of June 2026, there are 16 flights per day flying from Missouri to South Carolina. The most common time of day flights depart is 2:00PM, with 83% of flights taking off in the afternoon.

When did momondo last update prices for flights from Missouri to South Carolina?

Prices for flights from Missouri to South Carolina refresh daily.

How many operators does momondo search for flights from Missouri to South Carolina?

As of June 2026, there are 5 operators available to choose from for flights from Missouri to South Carolina.

How old do you have to be to fly from Missouri to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$89 Cheap Flights from Missouri to South Carolina in 2026

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Find the cheapest flights from Missouri to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:30 am - 3:40 pm

STL

CHS

6h 10m

1 stop

1:11 pm - 7:07 pm

CHS

STL

6h 56m

1 stop

$177American Airlines

Wed, Sep 9 - Tue, Sep 15

8:34 am - 1:16 pm

STL

CHS

3h 42m

1 stop

7:46 pm - 12:14 am

CHS

STL

5h 28m

1 stop

$184American Airlines

Wed, Aug 12 - Mon, Aug 17

5:38 am - 1:35 pm

MCI

CLT

6h 57m

1 stop

8:01 am - 12:15 pm

CLT

MCI

5h 14m

1 stop

$187Delta

Sat, Jun 20 - Sun, Jun 21

6:45 pm - 11:57 pm

STL

CHS

4h 12m

1 stop

4:10 pm - 7:44 pm

CHS

STL

4h 34m

1 stop

$191Delta

Mon, Sep 14 - Fri, Sep 18

5:40 am - 11:10 am

STL

CLT

4h 30m

1 stop

1:25 pm - 2:25 pm

CLT

STL

2h 00mnonstop

$227Southwest

Wed, Jul 1 - Wed, Jul 8

4:50 pm - 7:40 pm

STL

CLT

1h 50mnonstop

6:50 am - 1:05 pm

CLT

STL

7h 15m

2 stops

$232Southwest

Wed, Jul 1 - Wed, Jul 8

1:45 pm - 9:25 pm

MCI

CLT

6h 40m

1 stop

10:04 pm - 1:00 pm

CLT

MCI

15h 56m

1 stop

$240Frontier

Wed, Jul 1 - Wed, Jul 8

9:30 am - 3:04 pm

STL

SAV

4h 34m

1 stop

4:59 pm - 10:00 pm

SAV

STL

6h 01m

1 stop

$251United Airlines

Mon, Aug 17 - Thu, Aug 20

7:25 am - 1:56 pm

STL

CLT

5h 31m

1 stop

8:05 am - 12:02 pm

CLT

STL

4h 57m

1 stop

$251United Airlines

Sat, Sep 5 - Mon, Sep 7

4:09 pm - 11:29 am

STL

CLT

18h 20m

1 stop

12:24 pm - 11:59 pm

CLT

STL

12h 35m

1 stop

$254Frontier

Sat, Jul 25 - Wed, Jul 29

Frontier flights from Missouri to South Carolina

Our best Frontier deals on Missouri to South Carolina flight tickets

Frontier

Jul 1

MCI1:45 pmKansas City

6h 40m

1 stop

CLT9:25 pmCharlotte Douglas

Jul 8

CLT10:04 pmCharlotte Douglas

15h 56m

1 stop

MCI1:00 pmKansas City

$240

Frontier

Jul 25

STL4:09 pmLambert-St Louis

18h 20m

1 stop

CLT11:29 amCharlotte Douglas

Jul 29

CLT12:24 pmCharlotte Douglas

12h 35m

1 stop

STL11:59 pmLambert-St Louis

$254

Frontier

Jul 1

MCI1:45 pmKansas City

6h 40m

1 stop

CLT9:25 pmCharlotte Douglas

Jul 6

CLT10:04 pmCharlotte Douglas

15h 56m

1 stop

MCI1:00 pmKansas City

$259

American Airlines flights from Missouri to South Carolina

Our best American Airlines deals on Missouri to South Carolina flight tickets

American Airlines

Sep 9

STL8:30 amLambert-St Louis

6h 10m

1 stop

CHS3:40 pmCharleston

Sep 15

CHS1:11 pmCharleston

6h 56m

1 stop

STL7:07 pmLambert-St Louis

$177

American Airlines

Aug 12

STL8:34 amLambert-St Louis

3h 42m

1 stop

CHS1:16 pmCharleston

Aug 17

CHS7:46 pmCharleston

5h 28m

1 stop

STL12:14 amLambert-St Louis

$184

American Airlines

Jul 25

STL6:12 pmLambert-St Louis

2h 03m

CLT9:15 pmCharlotte Douglas

Jul 29

CLT10:56 pmCharlotte Douglas

2h 02m

STL11:58 pmLambert-St Louis

$217

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Wed 9/9

8:30 am-3:40 pm

1 stop6h 10m

Charleston

Tue 9/15

1:11 pm-7:07 pm

1 stop6h 56m

$177

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Wed 8/12

8:34 am-1:16 pm

1 stop3h 42m

Charleston

Mon 8/17

7:46 pm-12:14 am

1 stop5h 28m

$184

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Sat 6/20

5:38 am-1:35 pm

1 stop6h 57m

Charlotte Douglas

Sun 6/21

8:01 am-12:15 pm

1 stop5h 14m

$187

St. LouisCharleston

STL - CHS

STLCHS

Lambert-St Louis

Mon 9/14

6:45 pm-11:57 pm

1 stop4h 12m

Charleston

Fri 9/18

4:10 pm-7:44 pm

1 stop4h 34m

$191

Quickest round-trip

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 7/1

5:40 am-11:10 am

1 stop4h 30m

Charlotte Douglas

Wed 7/8

1:25 pm-2:25 pm

Nonstop2h 00m

$227

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Wed 7/1

4:50 pm-7:40 pm

Nonstop1h 50m

Charlotte Douglas

Wed 7/8

6:50 am-1:05 pm

2 stops7h 15m

$232

Kansas CityCharlotte

MCI - CLT

MCICLT

Kansas City

Wed 7/1

1:45 pm-9:25 pm

1 stop6h 40m

Charlotte Douglas

Wed 7/8

10:04 pm-1:00 pm

1 stop15h 56m

$240

St. LouisSavannah

STL - SAV

STLSAV

Lambert-St Louis

Mon 8/17

9:30 am-3:04 pm

1 stop4h 34m

Savannah/Hilton Head

Thu 8/20

4:59 pm-10:00 pm

1 stop6h 01m

$251

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 9/5

7:25 am-1:56 pm

1 stop5h 31m

Charlotte Douglas

Mon 9/7

8:05 am-12:02 pm

1 stop4h 57m

$251

St. LouisCharlotte

STL - CLT

STLCLT

Lambert-St Louis

Sat 7/25

4:09 pm-11:29 am

1 stop18h 20m

Charlotte Douglas

Wed 7/29

12:24 pm-11:59 pm

1 stop12h 35m

$254

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Missouri to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Missouri is in July. Flight prices, which tend to average around $89, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of July, then book flights to South Carolina from Missouri during September instead. Flights to South Carolina in September, while not as cheap as those in July, still average around $102.

What is the cheapest Missouri to South Carolina flight route?

Fly from Lambert-St Louis to Charleston for the best Missouri - South Carolina flight prices

How far in advance should I book a flight from Missouri to South Carolina?

You are more likely to see cheaper flights to South Carolina from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $373 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Missouri for as low as $253 on momondo.

What cabin class options are available on Missouri to South Carolina flights?

There is only 1 cabin class available to choose from on Missouri to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to South Carolina flights?

You could potentially save up to 23% on your flight if you consider stops on a Missouri to South Carolina flight.

Cheap Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South Carolina

Best Price Found	$336
Fastest flight time	1h 45m
Direct flights	Every day
Airports in South Carolina	57 airports

The best flight deal from Missouri to South Carolina found on momondo in the last 72 hours is $336

The fastest flight from Missouri to South Carolina takes 1h 45m

Direct flights go from Missouri to South Carolina every day.

There are 57 airports in South Carolina. From Missouri there are direct flights to Myrtle Beach Intl (MYR), Savannah/Hilton Head (SAV), Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Missouri to South Carolina

When did momondo last update prices for flights from Missouri to South Carolina?
Prices for flights from Missouri to South Carolina refresh daily.
How many operators does momondo search for flights from Missouri to South Carolina?
As of June 2026, there are 5 operators available to choose from for flights from Missouri to South Carolina.
How old do you have to be to fly from Missouri to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Missouri to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Missouri to South Carolina is Boeing 737-800 Passenger/BBJ2 (winglets), representing 63.41% of all bookings. The subsequent popular models are Boeing 737 MAX 8 at 17.07%, Boeing 737-700 Passenger/BBJ1 (winglets) at 7.32%, and Boeing 737 at 4.88%.

Best airlines flying from Missouri to South Carolina

Compare and see reviews for airlines that fly from Missouri to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $146	Free Cancellation	Rating 7.8 8,395 reviews	Search Delta flights
American Airlines	PriceFrom $193	Free Cancellation	Rating 7.1 11,641 reviews	Search American Airlines flights
United Airlines	PriceFrom $196	Free Cancellation	Rating 7.4 9,773 reviews	Search United Airlines flights
Southwest	PriceFrom $237	Free Cancellation	Rating 8.0 4,256 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to South Carolina?

Finding the right flight to South Carolina from Missouri is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Missouri to South Carolina with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to South Carolina from Missouri with this policy.

How can momondo help me find flights from Missouri to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Missouri.

I’m not ready to book a flight from Missouri to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Missouri to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

An easier way to manage your South Carolina trip

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Popular cities in South Carolina

Flights to New Yorkfrom $60

Flights to Los Angelesfrom $77

Flights to Orlandofrom $68

Flights to Miamifrom $78

Flights to Chicagofrom $64

Flights to San Franciscofrom $66

Flights to Las Vegasfrom $66

Flights to Washington, D.C.from $50

Flights to Bostonfrom $79

Flights to Atlantafrom $50

Flights to Fort Lauderdalefrom $59

Flights to Dallasfrom $63

Cheap flights from Missouri to South Carolina from $89

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to South Carolina departing on 8/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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Big names and deals

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Filter for what you want

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Find the cheapest flights from Missouri to South Carolina

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Frontier flights from Missouri to South Carolina

Our best Frontier deals on Missouri to South Carolina flight tickets

American Airlines flights from Missouri to South Carolina

Our best American Airlines deals on Missouri to South Carolina flight tickets

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How to get the cheapest flight ticket from Missouri to South Carolina

What is the cheapest month to fly to South Carolina?

What is the cheapest Missouri to South Carolina flight route?

How far in advance should I book a flight from Missouri to South Carolina?

What cabin class options are available on Missouri to South Carolina flights?

Can stopping save me money on Missouri to South Carolina flights?

What is the cheapest airline that flies from Missouri to South Carolina?

What airlines fly to South Carolina?

How many flights depart from Missouri to South Carolina on average per day?

How many flights depart from Missouri to South Carolina on average per week?

How long is the flight from Missouri to South Carolina?

Cheap Missouri to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

Frequently asked questions about flying from Missouri to South Carolina

Best airlines flying from Missouri to South Carolina

Compare and see reviews for airlines that fly from Missouri to South Carolina with momondo

Why use momondo?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo

Missouri flight routes

According to popular flight searches on momondo this year

South Carolina flight routes

According to popular flight searches on momondo this year

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According to popular flight searches on momondo this year