Cheap flights from Missouri to Pennsylvania from $59

The month of January is, on average, the cheapest month to fly to Pennsylvania from Missouri, with most prices found around $373. If you don’t want to visit Pennsylvania in January, then you should wait until September to fly from Missouri, when ticket prices are also cheap, with an average price of $378.

The cheapest day to depart on your flight to Pennsylvania is on a Friday when prices can be found for as low as $534. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Saturday because tickets tend to average around $815. These prices are subject to change though, so be sure to set up a Price Alert for flights to Pennsylvania.

Our most recent data shows that the best time of day to fly to Pennsylvania is in the evening. Flights from Missouri to Pennsylvania during this time can be as low as $443. In contrast, the most expensive time of day to depart to Pennsylvania is at noon when prices are around $904.

Fly from Lambert-St Louis to Pittsburgh for the best Missouri - Pennsylvania flight prices

You are more likely to see cheaper flights to Pennsylvania from Missouri when booking weeks ahead of your departure date. In general, you can expect to find flights to Pennsylvania for around $431 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Pennsylvania from Missouri for as low as $356 on momondo.

There are 4 cabin classes available to choose from on Missouri to Pennsylvania flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Frontier, Southwest, and United Airlines are the most popular carriers operating from Missouri to Pennsylvania

American Airlines, Southwest and United Airlines are the top three most popular airlines that fly to Pennsylvania from Missouri according to our data. American Airlines is the first choice among our users, with 55% of people opting to fly with this airline when traveling to Pennsylvania. Keep in mind that there are 5 different airlines that fly to Pennsylvania on a routine basis, so you have a few additional options to choose from.

As of August 2026, there are 70 flights per day flying from Missouri to Pennsylvania. The most common time of day flights depart is 11:00AM, with 59% of flights taking off at noon.

As of August 2026, there are 494 flights per week flying from Missouri to Pennsylvania. The most common day of the week flights depart is Thu, with 18% of flights taking off on this day.