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Cheap flights from Missouri to Des Moines from $105

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Des Moines departing on 7/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Find the cheapest flights from Missouri to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
5:40 am - 11:30 am
STL
-
DSM
5h 50m
1 stop
Southwest Logo
7:00 pm - 11:55 pm
DSM
-
STL
4h 55m
1 stop
$209Southwest
Tue, Jul 28 - Wed, Jul 29
Southwest Logo
5:55 pm - 10:50 pm
STL
-
DSM
4h 55m
1 stop
Southwest Logo
5:20 am - 2:45 pm
DSM
-
STL
9h 25m
2 stops
$214Southwest
Tue, Jul 28 - Wed, Jul 29
Southwest Logo
3:05 pm - 9:55 pm
STL
-
DSM
6h 50m
2 stops
Southwest Logo
2:40 pm - 10:10 pm
DSM
-
STL
7h 30m
2 stops
$219Southwest
Tue, Aug 4 - Wed, Aug 5
Southwest Logo
10:15 am - 10:50 pm
STL
-
DSM
12h 35m
2 stops
Southwest Logo
5:20 am - 2:50 pm
DSM
-
STL
9h 30m
2 stops
$225Southwest
Tue, Jul 28 - Wed, Jul 29
Frontier Logo
8:08 pm - 1:34 pm
STL
-
DSM
17h 26m
1 stop
Frontier Logo
2:19 pm - 7:23 pm
DSM
-
STL
5h 04m
1 stop
$229Frontier
Thu, Aug 6 - Wed, Aug 12
Delta Logo
6:20 am - 10:18 am
STL
-
DSM
3h 58m
1 stop
Delta Logo
6:55 am - 10:23 am
DSM
-
STL
3h 28m
1 stop
$235Delta
Tue, Aug 4 - Wed, Aug 5
United Airlines Logo
6:00 am - 10:17 am
STL
-
DSM
4h 17m
1 stop
United Airlines Logo
6:00 am - 12:11 pm
DSM
-
STL
6h 11m
1 stop
$263United Airlines
Wed, Jul 22 - Wed, Jul 29
Southwest Logo
5:55 pm - 10:50 pm
STL
-
DSM
4h 55m
1 stop
Southwest Logo
5:20 am - 2:45 pm
DSM
-
STL
9h 25m
2 stops
$268Southwest
Wed, Jul 22 - Wed, Jul 29
Southwest Logo
10:15 am - 9:55 pm
STL
-
DSM
11h 40m
2 stops
Southwest Logo
6:10 am - 2:25 pm
DSM
-
STL
8h 15m
2 stops
$273Southwest
Tue, Aug 25 - Wed, Aug 26
American Airlines Logo
9:08 am - 1:05 pm
STL
-
DSM
3h 57m
1 stop
American Airlines Logo
6:33 pm - 12:16 am
DSM
-
STL
5h 43m
1 stop
$277American Airlines
Wed, Jul 15 - Wed, Jul 22

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Southwest flights from Missouri to Des Moines

Our best Southwest deals on Missouri to Des Moines flight tickets
Southwest
Jul 28
STL5:40 amLambert-St Louis
5h 50m
1 stop
DSM11:30 amDes Moines
Jul 29
DSM7:00 pmDes Moines
4h 55m
1 stop
STL11:55 pmLambert-St Louis
$209
Southwest
Jul 28
STL5:55 pmLambert-St Louis
4h 55m
1 stop
DSM10:50 pmDes Moines
Jul 29
DSM5:20 amDes Moines
9h 25m
2 stops
STL2:45 pmLambert-St Louis
$214
Southwest
Aug 4
STL3:05 pmLambert-St Louis
6h 50m
2 stops
DSM9:55 pmDes Moines
Aug 5
DSM2:40 pmDes Moines
7h 30m
2 stops
STL10:10 pmLambert-St Louis
$219

American Airlines flights from Missouri to Des Moines

Our best American Airlines deals on Missouri to Des Moines flight tickets
American Airlines
Jul 15
STL9:08 amLambert-St Louis
3h 57m
1 stop
DSM1:05 pmDes Moines
Jul 22
DSM6:33 pmDes Moines
5h 43m
1 stop
STL12:16 amLambert-St Louis
$277
American Airlines
Jul 15
STL5:58 pmLambert-St Louis
6h 03m
1 stop
DSM12:01 amDes Moines
Jul 17
DSM6:33 pmDes Moines
5h 43m
1 stop
STL12:16 amLambert-St Louis
$304
American Airlines
Jul 15
STL7:56 pmLambert-St Louis
4h 05m
1 stop
DSM12:01 amDes Moines
Jul 17
DSM6:33 pmDes Moines
5h 43m
1 stop
STL12:16 amLambert-St Louis
$345

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 28, 2026.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 7/28

5:40 am-11:30 am

1 stop5h 50m

Des Moines

Wed 7/29

7:00 pm-11:55 pm

1 stop4h 55m

$209

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 7/28

5:55 pm-10:50 pm

1 stop4h 55m

Des Moines

Wed 7/29

5:20 am-2:45 pm

2 stops9h 25m

$214

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 8/4

3:05 pm-9:55 pm

2 stops6h 50m

Des Moines

Wed 8/5

2:40 pm-10:10 pm

2 stops7h 30m

$219

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 7/28

10:15 am-10:50 pm

2 stops12h 35m

Des Moines

Wed 7/29

5:20 am-2:50 pm

2 stops9h 30m

$225

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 8/6

8:08 pm-1:34 pm

1 stop17h 26m

Des Moines

Wed 8/12

2:19 pm-7:23 pm

1 stop5h 04m

$229
Quickest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 8/4

6:20 am-10:18 am

1 stop3h 58m

Des Moines

Wed 8/5

6:55 am-10:23 am

1 stop3h 28m

$235

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 7/22

6:00 am-10:17 am

1 stop4h 17m

Des Moines

Wed 7/29

6:00 am-12:11 pm

1 stop6h 11m

$263

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 7/22

5:55 pm-10:50 pm

1 stop4h 55m

Des Moines

Wed 7/29

5:20 am-2:45 pm

2 stops9h 25m

$268

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 8/25

10:15 am-9:55 pm

2 stops11h 40m

Des Moines

Wed 8/26

6:10 am-2:25 pm

2 stops8h 15m

$273

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 7/15

9:08 am-1:05 pm

1 stop3h 57m

Des Moines

Wed 7/22

6:33 pm-12:16 am

1 stop5h 43m

$277

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Missouri to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then April is your next best option. Flight prices from Missouri to Des Moines during April average around $0.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Missouri to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $234. Flights from Missouri to Des Moines on a Monday will generally be more expensive and average around $725. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Missouri to Des Moines in the morning for as low as $492. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $680. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Missouri - Des Moines flight prices

What cabin class options are available on Missouri to Des Moines flights?

There is only 1 cabin class available to choose from on Missouri to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Des Moines flights?

You could potentially save up to 24% on your flight if you consider stops on a Missouri to Des Moines flight.

Cheap Missouri to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Des Moines

Fastest flight time

3h 35m

Direct flights

None
The fastest flight from Missouri to Des Moines takes 3h 35m
There are no direct flights from Missouri to Des Moines. There are no popular flight routes from Missouri to Des Moines.
Search flight deals

Frequently asked questions about flying from Missouri to Des Moines

  • When did momondo last update prices for flights from Missouri to Des Moines Airport?

    Prices for flights from Missouri to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Des Moines Airport?

  • How old do you have to be to fly from Missouri to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Missouri to Des Moines?

Best airlines flying from Missouri to Des Moines

Compare and see reviews for airlines that fly from Missouri to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
7.9
4,246 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Osceola
Urbandale
Newton
Johnston
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Missouri.

Can I find flights from Missouri to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Des Moines?

Once you have performed a search for Missouri to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Missouri to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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Tue 7/28
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