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Cheap flights from Missouri to Des Moines from $123

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Des Moines departing on 9/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Missouri to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
7:27 am - 1:59 pmSTL  Lambert-St Louis-DSM Des Moines
6h 32m1 stop Chicago O'Hare Intl
American Airlines Logo
2:29 pm - 8:44 pmDSM  Des Moines-STL Lambert-St Louis
6h 15m1 stop Chicago O'Hare Intl
$235American Airlines
Thu, Sep 10 - Wed, Sep 16
American Airlines Logo
8:07 pm - 12:20 amSTL  Lambert-St Louis-DSM Des Moines
4h 13m1 stop Chicago O'Hare Intl
American Airlines Logo
7:58 pm - 12:27 amDSM  Des Moines-STL Lambert-St Louis
4h 29m1 stop Chicago O'Hare Intl
$240American Airlines
Tue, Sep 8 - Tue, Sep 15
Southwest Logo
6:30 am - 11:50 amSTL  Lambert-St Louis-DSM Des Moines
5h 20m1 stop Chicago Midway
Southwest Logo
6:10 am - 2:25 pmDSM  Des Moines-STL Lambert-St Louis
8h 15m2 stops Chicago Midway Dallas Love Field
$245Southwest
Tue, Sep 8 - Tue, Sep 15
Delta Logo
6:15 am - 10:17 amSTL  Lambert-St Louis-DSM Des Moines
4h 02m1 stop Minneapolis St Paul
Delta Logo
5:59 pm - 11:16 pmDSM  Des Moines-STL Lambert-St Louis
5h 17m1 stop Minneapolis St Paul
$245Delta
Thu, Sep 17 - Tue, Sep 22
American Airlines Logo
8:07 pm - 12:20 amSTL  Lambert-St Louis-DSM Des Moines
4h 13m1 stop Chicago O'Hare Intl
American Airlines Logo
2:44 pm - 8:44 pmDSM  Des Moines-STL Lambert-St Louis
6h 00m1 stop Chicago O'Hare Intl
$245American Airlines
Thu, Sep 3 - Thu, Sep 10
Southwest Logo
2:50 pm - 9:05 pmSTL  Lambert-St Louis-DSM Des Moines
6h 15m2 stops Kansas City Denver Intl
Southwest Logo
6:10 am - 2:50 pmDSM  Des Moines-STL Lambert-St Louis
8h 40m2 stops Chicago Midway Baltimore/Washington
$250Southwest
Tue, Sep 8 - Tue, Sep 15
Southwest Logo
4:40 pm - 10:00 pmSTL  Lambert-St Louis-DSM Des Moines
5h 20m1 stop Chicago Midway
Southwest Logo
5:25 am - 2:05 pmDSM  Des Moines-STL Lambert-St Louis
8h 40m2 stops Chicago Midway Atlanta Hartsfield-Jackson
$272Southwest
Thu, Dec 10 - Fri, Dec 11
United Airlines Logo
6:00 am - 12:20 pmSTL  Lambert-St Louis-DSM Des Moines
6h 20m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 10:12 amDSM  Des Moines-STL Lambert-St Louis
4h 12m1 stop Chicago O'Hare Intl
$297United Airlines
Fri, Sep 4 - Sat, Sep 5
United Airlines Logo
8:00 am - 12:34 pmSTL  Lambert-St Louis-DSM Des Moines
4h 34m1 stop Chicago O'Hare Intl
United Airlines Logo
3:11 pm - 9:21 pmDSM  Des Moines-STL Lambert-St Louis
6h 10m1 stop Chicago O'Hare Intl
$310United Airlines
Thu, Oct 15 - Mon, Oct 19
United Airlines Logo
12:59 pm - 5:28 pmSTL  Lambert-St Louis-DSM Des Moines
4h 29m1 stop Chicago O'Hare Intl
United Airlines Logo
11:32 am - 5:06 pmDSM  Des Moines-STL Lambert-St Louis
5h 34m1 stop Chicago O'Hare Intl
$310United Airlines
Sun, Aug 30 - Tue, Sep 1

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American Airlines flights from Missouri to Des Moines

Our best American Airlines deals on Missouri to Des Moines flight tickets
American Airlines
Sep 10
STL7:27 amLambert-St Louis
6h 32m
1 stop
DSM1:59 pmDes Moines
Sep 16
DSM2:29 pmDes Moines
6h 15m
1 stop
STL8:44 pmLambert-St Louis
$235
American Airlines
Sep 8
STL8:07 pmLambert-St Louis
4h 13m
1 stop
DSM12:20 amDes Moines
Sep 15
DSM7:58 pmDes Moines
4h 29m
1 stop
STL12:27 amLambert-St Louis
$240
American Airlines
Sep 3
STL8:07 pmLambert-St Louis
4h 13m
1 stop
DSM12:20 amDes Moines
Sep 10
DSM2:44 pmDes Moines
6h 00m
1 stop
STL8:44 pmLambert-St Louis
$245

Southwest flights from Missouri to Des Moines

Our best Southwest deals on Missouri to Des Moines flight tickets
Southwest
Sep 8
STL2:50 pmLambert-St Louis
6h 15m
2 stops
DSM9:05 pmDes Moines
Sep 15
DSM6:10 amDes Moines
8h 40m
2 stops
STL2:50 pmLambert-St Louis
$250
Southwest
Dec 10
STL4:40 pmLambert-St Louis
5h 20m
1 stop
DSM10:00 pmDes Moines
Dec 11
DSM5:25 amDes Moines
8h 40m
2 stops
STL2:05 pmLambert-St Louis
$272
Southwest
Sep 17
STL6:05 amLambert-St Louis
5h 20m
1 stop
DSM11:25 amDes Moines
Sep 22
DSM2:40 pmDes Moines
7h 35m
2 stops
STL10:15 pmLambert-St Louis
$276

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Thu 9/10

7:27 am-1:59 pm

1 stop6h 32m

Des Moines

Wed 9/16

2:29 pm-8:44 pm

1 stop6h 15m

$235
Quickest round-trip

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Tue 9/8

8:07 pm-12:20 am

1 stop4h 13m

Des Moines

Tue 9/15

7:58 pm-12:27 am

1 stop4h 29m

$240

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Tue 9/8

6:30 am-11:50 am

1 stop5h 20m

Des Moines

Tue 9/15

6:10 am-2:25 pm

2 stops8h 15m

$245

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Thu 9/17

6:15 am-10:17 am

1 stop4h 02m

Des Moines

Tue 9/22

5:59 pm-11:16 pm

1 stop5h 17m

$245

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Thu 9/3

8:07 pm-12:20 am

1 stop4h 13m

Des Moines

Thu 9/10

2:44 pm-8:44 pm

1 stop6h 00m

$245

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Tue 9/8

2:50 pm-9:05 pm

2 stops6h 15m

Des Moines

Tue 9/15

6:10 am-2:50 pm

2 stops8h 40m

$250

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Thu 12/10

4:40 pm-10:00 pm

1 stop5h 20m

Des Moines

Fri 12/11

5:25 am-2:05 pm

2 stops8h 40m

$272

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Fri 9/4

6:00 am-12:20 pm

1 stop6h 20m

Des Moines

Sat 9/5

6:00 am-10:12 am

1 stop4h 12m

$297

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Thu 10/15

8:00 am-12:34 pm

1 stop4h 34m

Des Moines

Mon 10/19

3:11 pm-9:21 pm

1 stop6h 10m

$310

St. LouisDes Moines

STL Lambert-St Louis - DSM Des Moines

STLDSM

Lambert-St Louis

Sun 8/30

12:59 pm-5:28 pm

1 stop4h 29m

Des Moines

Tue 9/1

11:32 am-5:06 pm

1 stop5h 34m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Missouri to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then April is your next best option. Flight prices from Missouri to Des Moines during April average around $0.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Missouri to Des Moines is on a Thursday. Travelers who choose to depart for Des Moines on a Thursday will often find tickets for as low as $234. Flights from Missouri to Des Moines on a Monday will generally be more expensive and average around $725. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Missouri to Des Moines in the morning for as low as $501. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $680. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Missouri - Des Moines flight prices

What cabin class options are available on Missouri to Des Moines flights?

There is only 1 cabin class available to choose from on Missouri to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Des Moines flights?

You could potentially save up to 69% on your flight if you consider stops on a Missouri to Des Moines flight.

Cheap Missouri to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Des Moines

Fastest flight time

4h 00m

Direct flights

None
The fastest flight from Missouri to Des Moines takes 4h 00m
There are no direct flights from Missouri to Des Moines. There are no popular flight routes from Missouri to Des Moines.
Search flight deals

Frequently asked questions about flying from Missouri to Des Moines

  • When did momondo last update prices for flights from Missouri to Des Moines Airport?

    Prices for flights from Missouri to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Des Moines Airport?

  • How old do you have to be to fly from Missouri to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Missouri to Des Moines?

Best airlines flying from Missouri to Des Moines

Compare and see reviews for airlines that fly from Missouri to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
8.0
4,220 reviews
Search Southwest flights
United AirlinesPriceFrom $218Free CancellationRating
7.4
10,110 reviews
Search United Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Missouri.

Can I find flights from Missouri to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Des Moines?

Once you have performed a search for Missouri to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Missouri to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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