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Cheap flights from Missouri to Des Moines from $59

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Des Moines departing on 4/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Missouri to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:36 pm - 11:40 pm
STL
-
DSM
5h 04m
1 stop
American Airlines Logo
7:44 pm - 11:48 pm
DSM
-
STL
4h 04m
1 stop
$181American Airlines
Mon, Mar 2 - Thu, Mar 5
Delta Logo
6:29 am - 10:09 am
STL
-
DSM
3h 40m
1 stop
Delta Logo
5:35 am - 11:09 am
DSM
-
STL
5h 34m
1 stop
$197Delta
Sun, Mar 29 - Tue, Mar 31
Delta Logo
6:29 am - 10:09 am
STL
-
DSM
3h 40m
1 stop
Delta Logo
6:55 am - 12:58 pm
DSM
-
STL
6h 03m
2 stops
$202Delta
Sun, Mar 29 - Tue, Mar 31
United Airlines Logo
7:41 am - 2:27 pm
STL
-
DSM
6h 46m
1 stop
United Airlines Logo
3:24 pm - 9:05 pm
DSM
-
STL
5h 41m
1 stop
$205United Airlines
Tue, Feb 24 - Sat, Feb 28
Delta Logo
10:14 am - 9:20 pm
STL
-
DSM
11h 06m
2 stops
Delta Logo
10:57 am - 2:54 pm
DSM
-
STL
3h 57m
1 stop
$210Delta
Tue, Feb 24 - Sat, Feb 28
Delta Logo
6:00 am - 11:05 am
STL
-
DSM
5h 05m
1 stop
Delta Logo
6:10 am - 1:05 pm
DSM
-
STL
6h 55m
1 stop
$220Delta
Sun, Apr 19 - Wed, Apr 22
Southwest Logo
5:35 am - 11:25 am
STL
-
DSM
5h 50m
1 stop
Southwest Logo
5:25 am - 1:15 pm
DSM
-
STL
7h 50m
2 stops
$225Southwest
Tue, Apr 21 - Thu, Apr 23
Southwest Logo
2:30 pm - 10:10 pm
STL
-
DSM
7h 40m
2 stops
Southwest Logo
5:25 am - 1:15 pm
DSM
-
STL
7h 50m
2 stops
$230Southwest
Tue, Apr 21 - Thu, Apr 23
United Airlines Logo
7:41 am - 2:27 pm
STL
-
DSM
6h 46m
1 stop
United Airlines Logo
3:24 pm - 9:05 pm
DSM
-
STL
5h 41m
1 stop
$253United Airlines
Wed, Feb 25 - Sat, Feb 28
Southwest Logo
5:45 pm - 11:45 pm
MCI
-
DSM
6h 00m
1 stop
Southwest Logo
5:10 am - 11:50 am
DSM
-
MCI
6h 40m
1 stop
$367Southwest
Sun, Jul 26 - Sat, Aug 1

American Airlines flights from Missouri to Des Moines

Our best American Airlines deals on Missouri to Des Moines flight tickets
American Airlines
Mar 2
STL6:36 pmLambert-St Louis
5h 04m
1 stop
DSM11:40 pmDes Moines
Mar 5
DSM7:44 pmDes Moines
4h 04m
1 stop
STL11:48 pmLambert-St Louis
$181
American Airlines
Aug 8
STL4:32 pmLambert-St Louis
7h 13m
1 stop
DSM11:45 pmDes Moines
Aug 10
DSM6:12 pmDes Moines
5h 43m
1 stop
STL11:55 pmLambert-St Louis
$354
American Airlines
Aug 7
STL5:27 amLambert-St Louis
5h 26m
1 stop
DSM10:53 amDes Moines
Aug 10
DSM6:12 pmDes Moines
5h 43m
1 stop
STL11:55 pmLambert-St Louis
$419

Southwest flights from Missouri to Des Moines

Our best Southwest deals on Missouri to Des Moines flight tickets
Southwest
Apr 21
STL5:35 amLambert-St Louis
5h 50m
1 stop
DSM11:25 amDes Moines
Apr 23
DSM5:25 amDes Moines
7h 50m
2 stops
STL1:15 pmLambert-St Louis
$225
Southwest
Apr 21
STL2:30 pmLambert-St Louis
7h 40m
2 stops
DSM10:10 pmDes Moines
Apr 23
DSM5:25 amDes Moines
7h 50m
2 stops
STL1:15 pmLambert-St Louis
$230
Southwest
Apr 19
STL1:15 pmLambert-St Louis
10h 05m
2 stops
DSM11:20 pmDes Moines
Apr 22
DSM6:30 pmDes Moines
4h 40m
1 stop
STL11:10 pmLambert-St Louis
$255

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 3/2

6:36 pm-11:40 pm

1 stop5h 04m

Des Moines

Thu 3/5

7:44 pm-11:48 pm

1 stop4h 04m

$181

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 3/29

6:29 am-10:09 am

1 stop3h 40m

Des Moines

Tue 3/31

5:35 am-11:09 am

1 stop5h 34m

$197

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 3/29

6:29 am-10:09 am

1 stop3h 40m

Des Moines

Tue 3/31

6:55 am-12:58 pm

2 stops6h 03m

$202

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 2/24

7:41 am-2:27 pm

1 stop6h 46m

Des Moines

Sat 2/28

3:24 pm-9:05 pm

1 stop5h 41m

$205

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 2/24

10:14 am-9:20 pm

2 stops11h 06m

Des Moines

Sat 2/28

10:57 am-2:54 pm

1 stop3h 57m

$210

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 4/19

6:00 am-11:05 am

1 stop5h 05m

Des Moines

Wed 4/22

6:10 am-1:05 pm

1 stop6h 55m

$220

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 4/21

5:35 am-11:25 am

1 stop5h 50m

Des Moines

Thu 4/23

5:25 am-1:15 pm

2 stops7h 50m

$225

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 4/21

2:30 pm-10:10 pm

2 stops7h 40m

Des Moines

Thu 4/23

5:25 am-1:15 pm

2 stops7h 50m

$230

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Wed 2/25

7:41 am-2:27 pm

1 stop6h 46m

Des Moines

Sat 2/28

3:24 pm-9:05 pm

1 stop5h 41m

$253

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Sun 7/26

5:45 pm-11:45 pm

1 stop6h 00m

Des Moines

Sat 8/1

5:10 am-11:50 am

1 stop6h 40m

$367

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Missouri to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Missouri to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $338. Flights from Missouri to Des Moines on a Sunday will generally be more expensive and average around $680. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from Missouri to Des Moines in the evening for as low as $171. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $487. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Missouri - Des Moines flight prices

What cabin class options are available on Missouri to Des Moines flights?

There is only 1 cabin class available to choose from on Missouri to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Des Moines flights?

You could potentially save up to 78% on your flight if you consider stops on a Missouri to Des Moines flight.

Cheap Missouri to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Des Moines

Best Price Found

$194

Fastest flight time

1h 10m

Direct flights

Mon, Fri and Sun

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Missouri in the past 72 hours is $194. The best round-trip flight deal from Missouri to Des Moines found on momondo in the last 72 hours is $467.
The fastest flight from Missouri to Des Moines takes 1h 10m
Direct flights go from Missouri to Des Moines on Monday, Friday and Sunday. The only airline offering direct flights is Southwest.
There is 1 airport in Des Moines. From Missouri there are direct flights to Des Moines (DSM).
Search flight deals

  • When did momondo last update prices for flights from Missouri to Des Moines Airport?

    Prices for flights from Missouri to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Des Moines Airport?

  • How old do you have to be to fly from Missouri to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Missouri to Des Moines?

Best airlines flying from Missouri to Des Moines

Compare and see reviews for airlines that fly from Missouri to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
8.0
4,282 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Urbandale
Clive
Pella
Newton
Johnston
Boone
Osceola
Norwalk
Oskaloosa
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Missouri.

Can I find flights from Missouri to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Des Moines?

Once you have performed a search for Missouri to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Missouri to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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