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Cheap flights from Missouri to Des Moines from $82

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Des Moines departing on 5/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Missouri to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
8:06 pm - 7:38 pm
STL
-
DSM
23h 32m
1 stop
Frontier Logo
2:16 pm - 7:23 pm
DSM
-
STL
5h 07m
1 stop
$201Frontier
Sun, May 3 - Mon, May 11
Southwest Logo
3:55 pm - 10:10 pm
STL
-
DSM
6h 15m
1 stop
Southwest Logo
6:30 pm - 11:10 pm
DSM
-
STL
4h 40m
1 stop
$213Southwest
Tue, Apr 14 - Tue, Apr 21
Southwest Logo
5:35 am - 11:25 am
STL
-
DSM
5h 50m
1 stop
Southwest Logo
6:55 am - 1:00 pm
DSM
-
STL
6h 05m
2 stops
$218Southwest
Tue, Apr 14 - Tue, Apr 21
Southwest Logo
1:15 pm - 10:10 pm
STL
-
DSM
8h 55m
2 stops
Southwest Logo
5:30 am - 3:15 pm
DSM
-
STL
9h 45m
2 stops
$223Southwest
Tue, Apr 14 - Tue, Apr 21
Delta Logo
6:45 am - 3:44 pm
STL
-
DSM
8h 59m
2 stops
Delta Logo
10:56 am - 2:31 pm
DSM
-
STL
3h 35m
1 stop
$224Delta
Sat, May 16 - Wed, May 20
Delta Logo
6:20 am - 10:16 am
STL
-
DSM
3h 56m
1 stop
Delta Logo
7:00 am - 11:32 am
DSM
-
STL
4h 32m
1 stop
$239Delta
Thu, Apr 23 - Thu, Apr 30
American Airlines Logo
6:11 pm - 11:59 pm
STL
-
DSM
5h 48m
1 stop
American Airlines Logo
5:01 pm - 10:17 pm
DSM
-
STL
5h 16m
1 stop
$242American Airlines
Mon, Apr 20 - Mon, Apr 27
Southwest Logo
5:40 am - 11:30 am
STL
-
DSM
5h 50m
1 stop
Southwest Logo
5:25 am - 10:15 am
DSM
-
STL
4h 50m
1 stop
$250Southwest
Sat, Apr 25 - Mon, Apr 27
Multiple Airlines Logo
12:24 pm - 1:46 pm
MCI
-
DSM
25h 22m
2 stops
Multiple Airlines Logo
2:36 pm - 11:29 am
DSM
-
MCI
20h 53m
1 stop
$425Multiple Airlines
Wed, Apr 8 - Sun, Apr 12
United Airlines Logo
6:00 am - 4:15 pm
MCI
-
DSM
10h 15m
1 stop
United Airlines Logo
5:50 am - 8:43 pm
DSM
-
MCI
14h 53m
1 stop
$481United Airlines
Tue, Jun 2 - Wed, Jun 3

Southwest flights from Missouri to Des Moines

Our best Southwest deals on Missouri to Des Moines flight tickets
Southwest
Apr 14
STL3:55 pmLambert-St Louis
6h 15m
1 stop
DSM10:10 pmDes Moines
Apr 21
DSM6:30 pmDes Moines
4h 40m
1 stop
STL11:10 pmLambert-St Louis
$213
Southwest
Apr 14
STL5:35 amLambert-St Louis
5h 50m
1 stop
DSM11:25 amDes Moines
Apr 21
DSM6:55 amDes Moines
6h 05m
2 stops
STL1:00 pmLambert-St Louis
$218
Southwest
Apr 14
STL1:15 pmLambert-St Louis
8h 55m
2 stops
DSM10:10 pmDes Moines
Apr 21
DSM5:30 amDes Moines
9h 45m
2 stops
STL3:15 pmLambert-St Louis
$223

Delta flights from Missouri to Des Moines

Our best Delta deals on Missouri to Des Moines flight tickets
Delta
May 16
STL6:45 amLambert-St Louis
8h 59m
2 stops
DSM3:44 pmDes Moines
May 20
DSM10:56 amDes Moines
3h 35m
1 stop
STL2:31 pmLambert-St Louis
$224
Delta
Apr 23
STL6:20 amLambert-St Louis
3h 56m
1 stop
DSM10:16 amDes Moines
Apr 30
DSM7:00 amDes Moines
4h 32m
1 stop
STL11:32 amLambert-St Louis
$239
Delta
May 16
STL6:45 amLambert-St Louis
8h 59m
2 stops
DSM3:44 pmDes Moines
May 20
DSM7:01 amDes Moines
6h 09m
2 stops
STL1:10 pmLambert-St Louis
$292

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sun 5/3

8:06 pm-7:38 pm

1 stop23h 32m

Des Moines

Mon 5/11

2:16 pm-7:23 pm

1 stop5h 07m

$201

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 4/14

3:55 pm-10:10 pm

1 stop6h 15m

Des Moines

Tue 4/21

6:30 pm-11:10 pm

1 stop4h 40m

$213

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 4/14

5:35 am-11:25 am

1 stop5h 50m

Des Moines

Tue 4/21

6:55 am-1:00 pm

2 stops6h 05m

$218

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 4/14

1:15 pm-10:10 pm

2 stops8h 55m

Des Moines

Tue 4/21

5:30 am-3:15 pm

2 stops9h 45m

$223

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sat 5/16

6:45 am-3:44 pm

2 stops8h 59m

Des Moines

Wed 5/20

10:56 am-2:31 pm

1 stop3h 35m

$224
Quickest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 4/23

6:20 am-10:16 am

1 stop3h 56m

Des Moines

Thu 4/30

7:00 am-11:32 am

1 stop4h 32m

$239

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 4/20

6:11 pm-11:59 pm

1 stop5h 48m

Des Moines

Mon 4/27

5:01 pm-10:17 pm

1 stop5h 16m

$242

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sat 4/25

5:40 am-11:30 am

1 stop5h 50m

Des Moines

Mon 4/27

5:25 am-10:15 am

1 stop4h 50m

$250

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Wed 4/8

12:24 pm-1:46 pm

2 stops25h 22m

Des Moines

Sun 4/12

2:36 pm-11:29 am

1 stop20h 53m

$425

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Tue 6/2

6:00 am-4:15 pm

1 stop10h 15m

Des Moines

Wed 6/3

5:50 am-8:43 pm

1 stop14h 53m

$481

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Missouri to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Missouri to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $338. Flights from Missouri to Des Moines on a Monday will generally be more expensive and average around $725. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from Missouri to Des Moines in the evening for as low as $280. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $467. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Missouri - Des Moines flight prices

What cabin class options are available on Missouri to Des Moines flights?

There is only 1 cabin class available to choose from on Missouri to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Missouri to Des Moines flights?

You could potentially save up to 61% on your flight if you consider stops on a Missouri to Des Moines flight.

Cheap Missouri to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Des Moines

Fastest flight time

3h 41m

Direct flights

None
The fastest flight from Missouri to Des Moines takes 3h 41m
There are no direct flights from Missouri to Des Moines. There are no popular flight routes from Missouri to Des Moines.
Search flight deals

  • When did momondo last update prices for flights from Missouri to Des Moines Airport?

    Prices for flights from Missouri to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Des Moines Airport?

  • How old do you have to be to fly from Missouri to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Missouri to Des Moines?

Best airlines flying from Missouri to Des Moines

Compare and see reviews for airlines that fly from Missouri to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
8.0
4,333 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Missouri.

Can I find flights from Missouri to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Des Moines?

Once you have performed a search for Missouri to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Missouri to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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