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Cheap flights from Missouri to Des Moines from $163

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Missouri to Des Moines departing on 5/22. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Missouri to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Frontier Logo
7:38 pm - 1:31 pm
STL
-
DSM
17h 53m
1 stop
Frontier Logo
2:16 pm - 7:23 pm
DSM
-
STL
5h 07m
1 stop
$262Frontier
Thu, Jun 11 - Wed, Jun 17
Southwest Logo
5:40 am - 11:35 am
STL
-
DSM
5h 55m
1 stop
Southwest Logo
5:20 am - 11:15 am
DSM
-
STL
5h 55m
1 stop
$305Southwest
Sat, Jun 13 - Tue, Jun 16
American Airlines Logo
6:35 am - 1:21 pm
STL
-
DSM
6h 46m
1 stop
American Airlines Logo
8:05 pm - 12:16 am
DSM
-
STL
4h 11m
1 stop
$306American Airlines
Tue, Jun 2 - Thu, Jun 4
Southwest Logo
6:15 pm - 10:10 pm
STL
-
DSM
3h 55m
1 stop
Southwest Logo
3:50 pm - 10:05 pm
DSM
-
STL
6h 15m
1 stop
$307Southwest
Mon, Aug 10 - Thu, Aug 13
Southwest Logo
5:35 am - 11:25 am
STL
-
DSM
5h 50m
1 stop
Southwest Logo
5:30 am - 9:30 am
DSM
-
STL
4h 00m
1 stop
$309Southwest
Tue, Jun 2 - Wed, Jun 3
Southwest Logo
6:30 pm - 11:30 pm
STL
-
DSM
5h 00m
1 stop
Southwest Logo
5:20 am - 2:50 pm
DSM
-
STL
9h 30m
2 stops
$310Southwest
Thu, Jun 11 - Wed, Jun 17
Southwest Logo
3:45 pm - 10:10 pm
STL
-
DSM
6h 25m
2 stops
Southwest Logo
5:40 am - 10:30 am
DSM
-
STL
4h 50m
1 stop
$312Southwest
Mon, Aug 10 - Thu, Aug 13
Southwest Logo
5:35 am - 11:25 am
STL
-
DSM
5h 50m
1 stop
Southwest Logo
5:30 am - 12:50 pm
DSM
-
STL
7h 20m
2 stops
$314Southwest
Tue, Jun 2 - Wed, Jun 3
Southwest Logo
2:30 pm - 11:30 pm
STL
-
DSM
9h 00m
2 stops
Southwest Logo
5:20 am - 2:45 pm
DSM
-
STL
9h 25m
2 stops
$315Southwest
Thu, Jun 11 - Wed, Jun 17
United Airlines Logo
11:33 am - 12:36 pm
MCI
-
DSM
25h 03m
1 stop
United Airlines Logo
1:35 pm - 4:22 pm
DSM
-
MCI
26h 47m
1 stop
$637United Airlines
Tue, Jun 9 - Mon, Jun 15

United Airlines flights from Missouri to Des Moines

Our best United Airlines deals on Missouri to Des Moines flight tickets
United Airlines
May 23
STL6:00 amLambert-St Louis
4h 27m
1 stop
DSM10:27 amDes Moines
May 27
DSM6:50 pmDes Moines
4h 02m
1 stop
STL10:52 pmLambert-St Louis
$321
United Airlines
Jun 9
STL6:00 amLambert-St Louis
4h 30m
1 stop
DSM10:30 amDes Moines
Jun 10
DSM11:26 amDes Moines
4h 20m
1 stop
STL3:46 pmLambert-St Louis
$363
United Airlines
Jun 9
STL1:13 pmLambert-St Louis
6h 12m
1 stop
DSM7:25 pmDes Moines
Jun 10
DSM5:17 pmDes Moines
6h 40m
1 stop
STL11:57 pmLambert-St Louis
$373

Delta flights from Missouri to Des Moines

Our best Delta deals on Missouri to Des Moines flight tickets
Delta
May 23
STL6:21 amLambert-St Louis
3h 55m
1 stop
DSM10:16 amDes Moines
May 27
DSM10:56 amDes Moines
6h 20m
2 stops
STL5:16 pmLambert-St Louis
$326
Delta
Aug 2
STL6:21 amLambert-St Louis
3h 52m
1 stop
DSM10:13 amDes Moines
Aug 6
DSM10:59 amDes Moines
6h 39m
2 stops
STL5:38 pmLambert-St Louis
$330
Delta
May 23
STL10:19 amLambert-St Louis
10h 53m
2 stops
DSM9:12 pmDes Moines
May 27
DSM10:56 amDes Moines
6h 20m
2 stops
STL5:16 pmLambert-St Louis
$331

momondo Fare Finder

 
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/11

7:38 pm-1:31 pm

1 stop17h 53m

Des Moines

Wed 6/17

2:16 pm-7:23 pm

1 stop5h 07m

$262

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Sat 6/13

5:40 am-11:35 am

1 stop5h 55m

Des Moines

Tue 6/16

5:20 am-11:15 am

1 stop5h 55m

$305

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/2

6:35 am-1:21 pm

1 stop6h 46m

Des Moines

Thu 6/4

8:05 pm-12:16 am

1 stop4h 11m

$306

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 8/10

6:15 pm-10:10 pm

1 stop3h 55m

Des Moines

Thu 8/13

3:50 pm-10:05 pm

1 stop6h 15m

$307
Quickest round-trip

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/2

5:35 am-11:25 am

1 stop5h 50m

Des Moines

Wed 6/3

5:30 am-9:30 am

1 stop4h 00m

$309

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/11

6:30 pm-11:30 pm

1 stop5h 00m

Des Moines

Wed 6/17

5:20 am-2:50 pm

2 stops9h 30m

$310

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Mon 8/10

3:45 pm-10:10 pm

2 stops6h 25m

Des Moines

Thu 8/13

5:40 am-10:30 am

1 stop4h 50m

$312

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Tue 6/2

5:35 am-11:25 am

1 stop5h 50m

Des Moines

Wed 6/3

5:30 am-12:50 pm

2 stops7h 20m

$314

St. LouisDes Moines

STL - DSM

STLDSM

Lambert-St Louis

Thu 6/11

2:30 pm-11:30 pm

2 stops9h 00m

Des Moines

Wed 6/17

5:20 am-2:45 pm

2 stops9h 25m

$315

Kansas CityDes Moines

MCI - DSM

MCIDSM

Kansas City

Tue 6/9

11:33 am-12:36 pm

1 stop25h 03m

Des Moines

Mon 6/15

1:35 pm-4:22 pm

1 stop26h 47m

$637

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Missouri to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then November is your next best option. Flight prices from Missouri to Des Moines during November average around $77.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Missouri to Des Moines is on a Wednesday. Travelers who choose to depart for Des Moines on a Wednesday will often find tickets for as low as $338. Flights from Missouri to Des Moines on a Monday will generally be more expensive and average around $725. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the morning. momondo users have found flights departing from Missouri to Des Moines in the morning for as low as $487. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the evening because they tend to be around $680. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Missouri to Des Moines flight route?

Fly from Lambert-St Louis to Des Moines for the best Missouri - Des Moines flight prices

Can stopping save me money on Missouri to Des Moines flights?

You could potentially save up to 56% on your flight if you consider stops on a Missouri to Des Moines flight.

Cheap Missouri to Des Moines flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Missouri to Des Moines

Fastest flight time

5h 32m

Direct flights

None
The fastest flight from Missouri to Des Moines takes 5h 32m
There are no direct flights from Missouri to Des Moines. There are no popular flight routes from Missouri to Des Moines.
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Frequently asked questions about flying from Missouri to Des Moines

  • When did momondo last update prices for flights from Missouri to Des Moines Airport?

    Prices for flights from Missouri to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Missouri to Des Moines Airport?

  • How old do you have to be to fly from Missouri to Des Moines Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Missouri to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Missouri to Des Moines?

Best airlines flying from Missouri to Des Moines

Compare and see reviews for airlines that fly from Missouri to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $77Free CancellationRating
7.9
4,296 reviews
Search Southwest flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Missouri to Des Moines?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Des Moines from Missouri.

Can I find flights from Missouri to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Missouri which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Missouri to Des Moines?

Once you have performed a search for Missouri to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Missouri to Des Moines right now. Can momondo alert me if prices change?

Price alerts on flights to Des Moines from Missouri are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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