What is the cheapest airline that flies from Chicago Midway to South Carolina?

Southwest and Delta are the most popular carriers operating from Chicago Midway to South Carolina

How many flights depart from Chicago Midway Airport to South Carolina on average per week?

6 flights are operational weekly from Chicago Midway Airport to South Carolina as of March 2026. The most popular departure day for this route is Tue, with 50% of flights per week taking off on this day.

When did momondo last update prices for flights from Chicago Midway Airport to South Carolina?

Prices for flights from Chicago Midway Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Chicago Midway Airport to South Carolina?

As of March 2026, there are 3 operators available to choose from for flights from Chicago Midway Airport to South Carolina.

How old do you have to be to fly from Chicago Midway Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$65 Cheap Flights from Chicago Midway Airport to South Carolina in 2026

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Find the cheapest flights from Chicago Midway Airport to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:30 am - 10:01 pm

MDW

CLT

13h 31m

1 stop

8:09 pm - 7:26 am

CLT

MDW

12h 17m

1 stop

$152Multiple Airlines

Wed, Apr 15 - Wed, Apr 22

9:30 am - 7:13 pm

MDW

CLT

8h 43m

1 stop

9:15 am - 10:19 pm

CLT

MDW

14h 04m

2 stops

$162Multiple Airlines

Tue, Mar 31 - Tue, Apr 7

9:14 am - 4:35 pm

MDW

CLT

6h 21m

1 stop

8:09 pm - 7:21 am

CLT

MDW

12h 12m

1 stop

$166Frontier

Sat, Apr 25 - Wed, Apr 29

9:14 am - 4:30 pm

MDW

CLT

6h 16m

1 stop

10:07 am - 8:04 am

CLT

MDW

22h 57m

1 stop

$171Frontier

Fri, Apr 17 - Sun, Apr 19

9:14 am - 4:30 pm

MDW

CLT

6h 16m

1 stop

7:19 pm - 8:04 am

CLT

MDW

13h 45m

1 stop

$173Frontier

Fri, Apr 17 - Sun, Apr 19

6:00 pm - 8:55 pm

MDW

CLT

1h 55mnonstop

7:35 am - 8:45 am

CLT

MDW

2h 10mnonstop

$177Southwest

Wed, Apr 15 - Wed, Apr 22

9:27 am - 4:00 pm

MDW

CLT

5h 33m

1 stop

9:36 am - 12:43 pm

CLT

MDW

4h 07m

1 stop

$181Delta

Mon, Apr 20 - Thu, Apr 23

6:00 am - 8:49 pm

MDW

CLT

13h 49m

2 stops

9:32 pm - 8:04 am

CLT

MDW

11h 32m

1 stop

$184Multiple Airlines

Wed, May 6 - Wed, May 13

6:25 pm - 10:45 pm

MDW

GSP

3h 20m

1 stop

1:55 pm - 7:30 pm

GSP

MDW

6h 35m

1 stop

$224Southwest

Fri, Apr 3 - Tue, Apr 7

5:10 pm - 11:43 pm

MDW

GSP

5h 33m

1 stop

7:20 am - 12:42 pm

GSP

MDW

6h 22m

1 stop

$228Delta

Fri, May 15 - Sun, May 17

Frontier flights from Chicago Midway Airport to South Carolina

Our best Frontier deals on Chicago Midway Airport to South Carolina flight tickets

Frontier

Apr 25

MDW9:14 amChicago Midway

6h 21m

1 stop

CLT4:35 pmCharlotte Douglas

Apr 29

CLT8:09 pmCharlotte Douglas

12h 12m

1 stop

MDW7:21 amChicago Midway

$166

Frontier

Apr 17

MDW9:14 amChicago Midway

6h 16m

1 stop

CLT4:30 pmCharlotte Douglas

Apr 19

CLT10:07 amCharlotte Douglas

22h 57m

1 stop

MDW8:04 amChicago Midway

$171

Frontier

Apr 17

MDW9:14 amChicago Midway

6h 16m

1 stop

CLT4:30 pmCharlotte Douglas

Apr 19

CLT7:19 pmCharlotte Douglas

13h 45m

1 stop

MDW8:04 amChicago Midway

$173

Southwest flights from Chicago Midway Airport to South Carolina

Our best Southwest deals on Chicago Midway Airport to South Carolina flight tickets

Southwest

Apr 15

MDW6:00 pmChicago Midway

1h 55m

CLT8:55 pmCharlotte Douglas

Apr 22

CLT7:35 amCharlotte Douglas

2h 10m

MDW8:45 amChicago Midway

$177

Southwest

Apr 5

MDW6:45 pmChicago Midway

1h 50m

CLT9:35 pmCharlotte Douglas

Apr 7

CLT6:20 pmCharlotte Douglas

2h 05m

MDW7:25 pmChicago Midway

$189

Southwest

Apr 1

MDW7:45 amChicago Midway

9h 35m

1 stop

CLT6:20 pmCharlotte Douglas

Apr 7

CLT6:20 pmCharlotte Douglas

2h 05m

MDW7:25 pmChicago Midway

$205

momondo Fare Finder

Use the filters below to find and compare flights from Chicago Midway Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Wed 4/15

7:30 am-10:01 pm

1 stop13h 31m

Charlotte Douglas

Wed 4/22

8:09 pm-7:26 am

1 stop12h 17m

$152

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Tue 3/31

9:30 am-7:13 pm

1 stop8h 43m

Charlotte Douglas

Tue 4/7

9:15 am-10:19 pm

2 stops14h 04m

$162

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Sat 4/25

9:14 am-4:35 pm

1 stop6h 21m

Charlotte Douglas

Wed 4/29

8:09 pm-7:21 am

1 stop12h 12m

$166

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Fri 4/17

9:14 am-4:30 pm

1 stop6h 16m

Charlotte Douglas

Sun 4/19

10:07 am-8:04 am

1 stop22h 57m

$171

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Fri 4/17

9:14 am-4:30 pm

1 stop6h 16m

Charlotte Douglas

Sun 4/19

7:19 pm-8:04 am

1 stop13h 45m

$173

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Wed 4/15

6:00 pm-8:55 pm

Nonstop1h 55m

Charlotte Douglas

Wed 4/22

7:35 am-8:45 am

Nonstop2h 10m

$177

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Mon 4/20

9:27 am-4:00 pm

1 stop5h 33m

Charlotte Douglas

Thu 4/23

9:36 am-12:43 pm

1 stop4h 07m

$181

ChicagoCharlotte

MDW - CLT

MDWCLT

Chicago Midway

Wed 5/6

6:00 am-8:49 pm

2 stops13h 49m

Charlotte Douglas

Wed 5/13

9:32 pm-8:04 am

1 stop11h 32m

$184

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Fri 4/3

6:25 pm-10:45 pm

1 stop3h 20m

Greenville

Tue 4/7

1:55 pm-7:30 pm

1 stop6h 35m

$224

ChicagoGreenville

MDW - GSP

MDWGSP

Chicago Midway

Fri 5/15

5:10 pm-11:43 pm

1 stop5h 33m

Greenville

Sun 5/17

7:20 am-12:42 pm

1 stop6h 22m

$228

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Chicago Midway Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Tuesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $311. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $549.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Chicago Midway Airport to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $341. Try not to purchase tickets in the morning because they tend to be around $367. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago Midway to South Carolina flight route?

Fly from Chicago Midway to Charleston for the best Chicago Midway - South Carolina flight prices

What cabin class options are available on Chicago Midway to South Carolina flights?

There is only 1 cabin class available to choose from on Chicago Midway to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago Midway Airport to South Carolina flights?

You could potentially save up to 11% on your flight if you consider stops on a Chicago Midway Airport to South Carolina flight.

Cheap Chicago Midway Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to South Carolina

Best Price Found	$367
Fastest flight time	1h 50m
Direct flights	Every day
Airports in South Carolina	57 airports

The best flight deal from Chicago Midway Airport to South Carolina found on momondo in the last 72 hours is $367

The fastest flight from Chicago Midway Airport to South Carolina takes 1h 50m

Direct flights go from Chicago Midway Airport to South Carolina every day.

There are 57 airports in South Carolina. From Chicago Midway Airport there are direct flights to Myrtle Beach Intl (MYR), Charlotte Douglas (CLT).

Search flight deals

When did momondo last update prices for flights from Chicago Midway Airport to South Carolina?
Prices for flights from Chicago Midway Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Chicago Midway Airport to South Carolina?
As of March 2026, there are 3 operators available to choose from for flights from Chicago Midway Airport to South Carolina.
How old do you have to be to fly from Chicago Midway Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Chicago Midway Airport to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Chicago Midway Airport to South Carolina is Airbus A319, representing 17.17% of all bookings. The subsequent popular models are Boeing 737-800 Passenger/BBJ2 (winglets) at 16.67%, Boeing 737 MAX 8 at 15.15%, and Embraer 175 at 14.65%.

Best airlines flying from Chicago Midway Airport to South Carolina

Compare and see reviews for airlines that fly from Chicago Midway Airport to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $118	Free Cancellation	Rating 7.9 8,242 reviews		Search Delta flights
Southwest	PriceFrom $153	Free Cancellation	Rating 8.0 4,301 reviews		Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to South Carolina for you.

Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?

All flight searches from Chicago to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Chicago.

I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Chicago and alert you when they change.