How many flights depart from Chicago Midway Airport to South Carolina on average per week?

4 flights are operational weekly from Chicago Midway Airport to South Carolina as of October 2026. The most popular departure day for this route is Tue, with 50% of flights per week taking off on this day.

What is the cheapest airline that flies from Chicago Midway to South Carolina?

Southwest and Delta are the most popular carriers operating from Chicago Midway to South Carolina

When did momondo last update prices for flights from Chicago Midway Airport to South Carolina?

Prices for flights from Chicago Midway Airport to South Carolina are refreshed on a daily basis.

How many operators does momondo search for flights from Chicago Midway Airport to South Carolina?

As of October 2026, there are 2 operators available to choose from for flights from Chicago Midway Airport to South Carolina.

How old do you have to be to fly from Chicago Midway Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$110 Cheap Flights from Chicago Midway Airport to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Chicago Midway Airport to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:40 pm - 5:45 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

8:00 am - 9:15 amCHS Charleston-MDW Chicago Midway

2h 15mnonstop

$297Southwest

Thu, Nov 26 - Tue, Dec 1

1:25 pm - 4:30 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

8:00 am - 9:15 amCHS Charleston-MDW Chicago Midway

2h 15mnonstop

$297Southwest

Thu, Dec 10 - Mon, Dec 14

1:30 pm - 4:40 pmMDW Chicago Midway-CHS Charleston

2h 10mnonstop

7:10 pm - 8:25 pmCHS Charleston-MDW Chicago Midway

2h 15mnonstop

$297Southwest

Wed, Oct 28 - Mon, Nov 2

7:15 pm - 10:20 pmMDW Chicago Midway-CHS Charleston

2h 05mnonstop

8:00 am - 9:15 amCHS Charleston-MDW Chicago Midway

2h 15mnonstop

$297Southwest

Wed, Dec 23 - Thu, Dec 31

1:30 pm - 4:40 pmMDW Chicago Midway-CHS Charleston

2h 10mnonstop

7:15 am - 8:25 amCHS Charleston-MDW Chicago Midway

2h 10mnonstop

$297Southwest

Tue, Oct 27 - Wed, Oct 28

1:30 pm - 4:40 pmMDW Chicago Midway-CHS Charleston

2h 10mnonstop

7:15 pm - 8:25 pmCHS Charleston-MDW Chicago Midway

2h 10mnonstop

$297Southwest

Tue, Oct 27 - Thu, Oct 29

1:30 pm - 4:40 pmMDW Chicago Midway-CHS Charleston

2h 10mnonstop

7:10 pm - 8:25 pmCHS Charleston-MDW Chicago Midway

2h 15mnonstop

$297Southwest

Wed, Oct 28 - Mon, Nov 2

8:15 am - 11:20 amMDW Chicago Midway-CHS Charleston

2h 05mnonstop

7:15 am - 8:25 amCHS Charleston-MDW Chicago Midway

2h 10mnonstop

$297Southwest

Sat, Oct 24 - Tue, Oct 27

11:27 am - 4:29 pmMDW Chicago Midway-CHS Charleston

4h 02m1 stop Atlanta Hartsfield-Jackson

5:34 pm - 10:54 pmCHS Charleston-MDW Chicago Midway

6h 20m1 stop Atlanta Hartsfield-Jackson

$317Delta

Thu, Nov 26 - Tue, Dec 1

6:00 am - 11:26 amMDW Chicago Midway-CHS Charleston

4h 26m1 stop Atlanta Hartsfield-Jackson

5:55 pm - 10:10 pmCHS Charleston-MDW Chicago Midway

5h 15m1 stop Atlanta Hartsfield-Jackson

$317Delta

Thu, Feb 18 - Tue, Mar 2

Cheap last minute flights

Enter your travel dates to find the best prices.

6:05 am - 12:50 pmMDW Chicago Midway-GSP Greenville

5h 45m1 stop Atlanta Hartsfield-Jackson

7:20 am - 12:47 pmGSP Greenville-MDW Chicago Midway

6h 27m1 stop Detroit Metropolitan Wayne County

$401Delta

Sat, Oct 3 - Mon, Oct 12

5:06 pm - 9:50 pmMDW Chicago Midway-GSP Greenville

3h 44m1 stop Atlanta Hartsfield-Jackson

7:14 pm - 10:33 pmGSP Greenville-MDW Chicago Midway

4h 19m1 stop Atlanta Hartsfield-Jackson

$414Delta

Mon, Oct 5 - Mon, Oct 12

12:49 pm - 6:09 pmMDW Chicago Midway-GSP Greenville

4h 20m1 stop Atlanta Hartsfield-Jackson

12:54 pm - 6:00 pmGSP Greenville-MDW Chicago Midway

6h 06m1 stop Detroit Metropolitan Wayne County

$423Delta

Tue, Oct 6 - Sat, Oct 10

11:35 am - 5:46 pmMDW Chicago Midway-GSP Greenville

5h 11m1 stop Atlanta Hartsfield-Jackson

12:54 pm - 6:00 pmGSP Greenville-MDW Chicago Midway

6h 06m1 stop Detroit Metropolitan Wayne County

$423Delta

Sat, Oct 3 - Sat, Oct 10

8:40 am - 7:30 pmMDW Chicago Midway-GSP Greenville

9h 50m2 stops Nashville Intl Baltimore/Washington

5:35 pm - 9:45 pmGSP Greenville-MDW Chicago Midway

5h 10m1 stop Nashville Intl

$428Southwest

Sat, Oct 3 - Sat, Oct 10

1:40 pm - 8:05 pmMDW Chicago Midway-GSP Greenville

5h 25m2 stops Cincinnati Cinci./N. Kentucky Baltimore/Washington

12:45 pm - 4:10 pmGSP Greenville-MDW Chicago Midway

4h 25m1 stop Baltimore/Washington

$428Southwest

Tue, Oct 6 - Sat, Oct 10

1:35 pm - 8:05 pmMDW Chicago Midway-GSP Greenville

5h 30m2 stops Cleveland Hopkins Intl Baltimore/Washington

11:20 am - 6:45 pmGSP Greenville-MDW Chicago Midway

8h 25m2 stops Nashville Intl Baltimore/Washington

$433Southwest

Tue, Oct 6 - Sat, Oct 10

6:55 am - 5:00 pmMDW Chicago Midway-GSP Greenville

9h 05m2 stops Baltimore/Washington Nashville Intl

12:45 pm - 5:50 pmGSP Greenville-MDW Chicago Midway

6h 05m2 stops Baltimore/Washington Greater Rochester Intl

$433Southwest

Sat, Oct 3 - Sat, Oct 10

5:06 pm - 9:50 pmMDW Chicago Midway-GSP Greenville

3h 44m1 stop Atlanta Hartsfield-Jackson

12:54 pm - 6:00 pmGSP Greenville-MDW Chicago Midway

6h 06m1 stop Detroit Metropolitan Wayne County

$436Delta

Mon, Oct 5 - Sat, Oct 10

11:35 am - 5:46 pmMDW Chicago Midway-GSP Greenville

5h 11m1 stop Atlanta Hartsfield-Jackson

7:00 am - 10:03 amGSP Greenville-MDW Chicago Midway

4h 03m1 stop Atlanta Hartsfield-Jackson

$436Delta

Sat, Oct 3 - Sun, Oct 11

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Delta flights from Chicago Midway Airport to South Carolina

Our best Delta deals on Chicago Midway Airport to South Carolina flight tickets

Delta

Oct 29

MDW6:04 amChicago Midway

4h 31m

1 stop

CHS11:35 amCharleston

Oct 31

CHS12:09 pmCharleston

4h 08m

1 stop

MDW3:17 pmChicago Midway

$317

Delta

Nov 13

MDW5:13 pmChicago Midway

3h 51m

1 stop

CHS10:04 pmCharleston

Nov 16

CHS7:04 pmCharleston

4h 50m

1 stop

MDW10:54 pmChicago Midway

$328

Delta

Oct 30

MDW6:04 amChicago Midway

3h 56m

1 stop

GSP11:00 amGreenville

Nov 1

GSP7:20 amGreenville

6h 27m

1 stop

MDW12:47 pmChicago Midway

$339

Southwest flights from Chicago Midway Airport to South Carolina

Our best Southwest deals on Chicago Midway Airport to South Carolina flight tickets

Southwest

Oct 27

MDW1:30 pmChicago Midway

2h 10m

CHS4:40 pmCharleston

Oct 28

CHS7:15 amCharleston

2h 10m

MDW8:25 amChicago Midway

$297

Southwest

Oct 27

MDW1:30 pmChicago Midway

2h 10m

CHS4:40 pmCharleston

Oct 29

CHS4:45 pmCharleston

4h 10m

1 stop

MDW7:55 pmChicago Midway

$303

Southwest

Nov 5

MDW5:20 pmChicago Midway

6h 15m

1 stop

CHS12:35 amCharleston

Nov 9

CHS7:10 pmCharleston

2h 15m

MDW8:25 pmChicago Midway

$307

momondo Fare Finder

Use the filters below to find and compare flights from Chicago Midway Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Thu 11/26

2:40 pm-5:45 pm

Nonstop2h 05m

Charleston

Tue 12/1

8:00 am-9:15 am

Nonstop2h 15m

$297

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Thu 12/10

1:25 pm-4:30 pm

Nonstop2h 05m

Charleston

Mon 12/14

8:00 am-9:15 am

Nonstop2h 15m

$297

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Wed 10/28

1:30 pm-4:40 pm

Nonstop2h 10m

Charleston

Mon 11/2

7:10 pm-8:25 pm

Nonstop2h 15m

$297

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Wed 12/23

7:15 pm-10:20 pm

Nonstop2h 05m

Charleston

Thu 12/31

8:00 am-9:15 am

Nonstop2h 15m

$297

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Tue 10/27

1:30 pm-4:40 pm

Nonstop2h 10m

Charleston

Wed 10/28

7:15 am-8:25 am

Nonstop2h 10m

$297

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Tue 10/27

1:30 pm-4:40 pm

Nonstop2h 10m

Charleston

Thu 10/29

7:15 pm-8:25 pm

Nonstop2h 10m

$297

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Wed 10/28

1:30 pm-4:40 pm

Nonstop2h 10m

Charleston

Mon 11/2

7:10 pm-8:25 pm

Nonstop2h 15m

$297

Quickest round-trip

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Sat 10/24

8:15 am-11:20 am

Nonstop2h 05m

Charleston

Tue 10/27

7:15 am-8:25 am

Nonstop2h 10m

$297

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Thu 11/26

11:27 am-4:29 pm

1 stop4h 02m

Charleston

Tue 12/1

5:34 pm-10:54 pm

1 stop6h 20m

$317

ChicagoCharleston

MDW Chicago Midway - CHS Charleston

MDWCHS

Chicago Midway

Thu 2/18

6:00 am-11:26 am

1 stop4h 26m

Charleston

Tue 3/2

5:55 pm-10:10 pm

1 stop5h 15m

$317

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Chicago Midway Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Chicago Midway Airport is in February. Flight prices, which tend to average around $313, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to South Carolina from Chicago Midway Airport during January instead. Flights to South Carolina in January, while not as cheap as those in February, still average around $327.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Wednesday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $323. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $503.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Chicago Midway Airport to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $389. Try not to purchase tickets in the morning because they tend to be around $403. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Chicago Midway to South Carolina flight route?

Fly from Chicago Midway to Charleston for the best Chicago Midway - South Carolina flight prices

What cabin class options are available on Chicago Midway Airport to South Carolina flights?

There is only 1 cabin class available to choose from on Chicago Midway Airport to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Chicago Midway Airport to South Carolina flights?

You could potentially save up to 8% on your flight if you consider stops on a Chicago Midway Airport to South Carolina flight.

Cheap Chicago Midway Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago Midway Airport to South Carolina

Best Price Found	$110
Fastest flight time	1h 50m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Chicago Midway Airport in the past 72 hours is $110. The best round-trip flight deal from Chicago Midway Airport to South Carolina found on momondo in the last 72 hours is $297.

The fastest flight from Chicago Midway Airport to South Carolina takes 1h 50m

Direct flights go from Chicago Midway Airport to South Carolina every day.

There are 57 airports in South Carolina. From Chicago Midway Airport there are direct flights to Myrtle Beach Intl (MYR), Charleston (CHS).

Search flight deals

Frequently asked questions about flying from Chicago Midway Airport to South Carolina

When did momondo last update prices for flights from Chicago Midway Airport to South Carolina?
Prices for flights from Chicago Midway Airport to South Carolina are refreshed on a daily basis.
How many operators does momondo search for flights from Chicago Midway Airport to South Carolina?
As of October 2026, there are 2 operators available to choose from for flights from Chicago Midway Airport to South Carolina.
How old do you have to be to fly from Chicago Midway Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago Midway Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular plane model from Chicago Midway Airport to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Chicago Midway Airport to South Carolina is Boeing 737-800, representing 16.30% of all bookings. The subsequent popular models are Boeing 737 MAX 8 at 15.93%, Airbus A319 at 15.19%, and Embraer 175 (Enhanced Winglets) at 13.70%.

Best airlines flying from Chicago Midway Airport to South Carolina

Compare and see reviews for airlines that fly from Chicago Midway Airport to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $195	Free Cancellation	Rating 7.8 8,618 reviews		Search Delta flights
Southwest	PriceFrom $244	Free Cancellation	Rating 8.0 4,208 reviews		Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to South Carolina?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Chicago to South Carolina for you.

Can I find flights from Chicago to South Carolina with flexible booking policies on momondo?

All flight searches from Chicago to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Chicago to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Chicago.

I’m not ready to book a flight from Chicago to South Carolina right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South Carolina, momondo offers a useful price alert feature which will track prices for flights to South Carolina from Chicago and alert you when they change.