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Cheap flights from Medford to Knoxville from $229

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Medford to Knoxville departing on 3/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Medford to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
1:08 pm - 10:38 pm
MFR
-
TYS
6h 30m
1 stop
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
MFR
13h 30m
2 stops
$462United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
6:26 pm - 10:08 am
MFR
-
TYS
12h 42m
2 stops
United Airlines Logo
5:45 am - 5:45 pm
TYS
-
MFR
15h 00m
2 stops
$467United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
1:08 pm - 10:38 pm
MFR
-
TYS
6h 30m
1 stop
United Airlines Logo
12:05 pm - 10:41 pm
TYS
-
MFR
13h 36m
2 stops
$482United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
6:26 pm - 10:08 am
MFR
-
TYS
12h 42m
2 stops
United Airlines Logo
12:05 pm - 10:41 pm
TYS
-
MFR
13h 36m
2 stops
$487United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
6:35 pm - 10:42 am
MFR
-
TYS
13h 07m
2 stops
United Airlines Logo
4:56 pm - 9:16 pm
TYS
-
MFR
7h 20m
1 stop
$490United Airlines
Tue, Aug 4 - Thu, Aug 13
United Airlines Logo
6:35 pm - 10:05 am
MFR
-
TYS
12h 30m
2 stops
United Airlines Logo
12:05 pm - 10:41 pm
TYS
-
MFR
13h 36m
2 stops
$503United Airlines
Tue, Aug 4 - Thu, Aug 13
Alaska Airlines Logo
5:14 am - 8:21 pm
MFR
-
TYS
12h 07m
2 stops
Alaska Airlines Logo
1:40 pm - 12:33 am
TYS
-
MFR
13h 53m
2 stops
$523Alaska Airlines
Sat, Aug 22 - Wed, Aug 26
Alaska Airlines Logo
7:35 pm - 10:58 am
MFR
-
TYS
12h 23m
2 stops
Alaska Airlines Logo
3:01 pm - 12:04 am
TYS
-
MFR
12h 03m
2 stops
$539Alaska Airlines
Tue, Jul 28 - Mon, Aug 10
United Airlines Logo
1:08 pm - 10:38 pm
MFR
-
TYS
6h 30m
1 stop
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
MFR
13h 30m
2 stops
$544United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
2:06 pm - 10:08 am
MFR
-
TYS
17h 02m
3 stops
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
MFR
13h 30m
2 stops
$557United Airlines
Sat, Aug 22 - Wed, Aug 26

United Airlines flights from Medford to Knoxville

Our best United Airlines deals on Medford to Knoxville flight tickets
United Airlines
Aug 22
MFR1:08 pmMedford
6h 30m
1 stop
TYS10:38 pmKnoxville McGhee Tyson
Aug 26
TYS7:15 amKnoxville McGhee Tyson
13h 30m
2 stops
MFR5:45 pmMedford
$462
United Airlines
Aug 22
MFR6:26 pmMedford
12h 42m
2 stops
TYS10:08 amKnoxville McGhee Tyson
Aug 26
TYS5:45 amKnoxville McGhee Tyson
15h 00m
2 stops
MFR5:45 pmMedford
$467
United Airlines
Aug 22
MFR1:08 pmMedford
6h 30m
1 stop
TYS10:38 pmKnoxville McGhee Tyson
Aug 26
TYS12:05 pmKnoxville McGhee Tyson
13h 36m
2 stops
MFR10:41 pmMedford
$482

Alaska Airlines flights from Medford to Knoxville

Our best Alaska Airlines deals on Medford to Knoxville flight tickets
Alaska Airlines
Aug 22
MFR8:45 amMedford
10h 09m
2 stops
TYS9:54 pmKnoxville McGhee Tyson
Aug 26
TYS3:01 pmKnoxville McGhee Tyson
12h 32m
2 stops
MFR12:33 amMedford
$487
Alaska Airlines
Aug 22
MFR5:14 amMedford
12h 07m
2 stops
TYS8:21 pmKnoxville McGhee Tyson
Aug 26
TYS1:40 pmKnoxville McGhee Tyson
13h 53m
2 stops
MFR12:33 amMedford
$523
Alaska Airlines
Jul 28
MFR7:50 pmMedford
12h 23m
2 stops
TYS11:13 amKnoxville McGhee Tyson
Aug 10
TYS2:16 pmKnoxville McGhee Tyson
12h 48m
2 stops
MFR12:04 amMedford
$607

momondo Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 17, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/22

1:08 pm-10:38 pm

1 stop6h 30m

Knoxville McGhee Tyson

Wed 8/26

7:15 am-5:45 pm

2 stops13h 30m

$462

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/22

6:26 pm-10:08 am

2 stops12h 42m

Knoxville McGhee Tyson

Wed 8/26

5:45 am-5:45 pm

2 stops15h 00m

$467

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/22

1:08 pm-10:38 pm

1 stop6h 30m

Knoxville McGhee Tyson

Wed 8/26

12:05 pm-10:41 pm

2 stops13h 36m

$482

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/22

6:26 pm-10:08 am

2 stops12h 42m

Knoxville McGhee Tyson

Wed 8/26

12:05 pm-10:41 pm

2 stops13h 36m

$487

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 8/4

6:35 pm-10:42 am

2 stops13h 07m

Knoxville McGhee Tyson

Thu 8/13

4:56 pm-9:16 pm

1 stop7h 20m

$490

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 8/4

6:35 pm-10:05 am

2 stops12h 30m

Knoxville McGhee Tyson

Thu 8/13

12:05 pm-10:41 pm

2 stops13h 36m

$503

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/22

5:14 am-8:21 pm

2 stops12h 07m

Knoxville McGhee Tyson

Wed 8/26

1:40 pm-12:33 am

2 stops13h 53m

$523

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Tue 7/28

7:35 pm-10:58 am

2 stops12h 23m

Knoxville McGhee Tyson

Mon 8/10

3:01 pm-12:04 am

2 stops12h 03m

$539

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/22

1:08 pm-10:38 pm

1 stop6h 30m

Knoxville McGhee Tyson

Wed 8/26

7:15 am-5:45 pm

2 stops13h 30m

$544

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/22

2:06 pm-10:08 am

3 stops17h 02m

Knoxville McGhee Tyson

Wed 8/26

7:15 am-5:45 pm

2 stops13h 30m

$557

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
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When to book flights from Medford to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Medford to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medford to Knoxville (MFR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medford to Knoxville

Fastest flight time

6h 30m

Direct flights

None
The fastest flight from Medford to Knoxville takes 6h 30m
There are no direct flights from Medford to Knoxville. There are no popular flight routes from Medford to Knoxville.
Search flight deals

  • How far is Medford to Knoxville McGhee Tyson by plane?

    Medford and Knoxville McGhee Tyson are 2112.6 mi apart from one another. Typically, this will take 6h 30m by plane in normal conditions.

  • When did momondo last update prices for flights from Medford Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Medford Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Medford Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Medford Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Medford Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Medford to Knoxville?

Best airlines flying from Medford to Knoxville

Compare and see reviews for airlines that fly from Medford to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $348Free CancellationRating
7.4
9,431 reviews
Search United Airlines flights

  • How do I get Price Alerts for flights from Medford to Knoxville?

    Price Alerts will notify you by email when the price for flights to Knoxville from Medford decreases. To activate this, select your desired travel dates and search for offers. While browsing through offers you’ll see the Price Alert widget toggle. Click it to turn on notifications.

  • How can I save money on flights from Medford to Knoxville with momondo?

    By using tools like our “Price Calendar”, you can see the best day to fly round-trip for your travels. Our “Price Forecast” tool uses AI to predict whether you should purchase or hold off on booking for potentially cheaper prices. Explore shows you all flight options from a city or airport to build your own unique adventure. The Discover blog also provides valuable insights for saving money while booking your experience. After searching you can toggle on “Price Alerts” to track prices for your desired flight and book at the ideal moment.

  • How does momondo find its flight prices?

    We show prices from over 700+ competitors with a single click. With options from airlines and OTAs from across our 30 international markets, we are able to show you a diverse range of deals to create your adventure.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Medford to Knoxville?

Finding the right flight to Knoxville from Medford is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Medford to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Medford with this policy.

How can momondo help me find flights from Medford to Knoxville?

momondo helps you find the best flight between Medford and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Medford to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Medford. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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