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Cheap flights from Medford to Knoxville from $357

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Medford to Knoxville departing on 8/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Medford to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
United Airlines Logo
1:08 pm - 10:38 pm
MFR
-
TYS
6h 30m
1 stop
United Airlines Logo
8:48 am - 1:00 pm
TYS
-
MFR
7h 12m
1 stop
$357United Airlines
Wed, Aug 19 - Sat, Aug 22
United Airlines Logo
6:26 pm - 11:17 am
MFR
-
TYS
13h 51m
2 stops
United Airlines Logo
8:48 am - 1:00 pm
TYS
-
MFR
7h 12m
1 stop
$404United Airlines
Wed, Aug 19 - Sat, Aug 22
United Airlines Logo
5:00 am - 3:53 pm
MFR
-
TYS
7h 53m
1 stop
United Airlines Logo
1:54 pm - 10:59 pm
TYS
-
MFR
12h 05m
2 stops
$464United Airlines
Sat, May 23 - Fri, May 29
United Airlines Logo
1:08 pm - 10:38 pm
MFR
-
TYS
6h 30m
1 stop
United Airlines Logo
4:56 pm - 9:16 pm
TYS
-
MFR
7h 20m
1 stop
$467United Airlines
Sat, Aug 29 - Tue, Sep 1
United Airlines Logo
1:08 pm - 10:38 pm
MFR
-
TYS
6h 30m
1 stop
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
MFR
13h 30m
2 stops
$472United Airlines
Sat, Aug 29 - Tue, Sep 1
United Airlines Logo
6:26 pm - 10:08 am
MFR
-
TYS
12h 42m
2 stops
United Airlines Logo
7:15 am - 5:45 pm
TYS
-
MFR
13h 30m
2 stops
$477United Airlines
Sat, Aug 29 - Tue, Sep 1
Alaska Airlines Logo
7:08 am - 11:56 pm
MFR
-
TYS
13h 48m
2 stops
Alaska Airlines Logo
1:14 pm - 11:59 pm
TYS
-
MFR
13h 45m
2 stops
$483Alaska Airlines
Sat, May 23 - Fri, May 29
United Airlines Logo
5:00 am - 3:54 pm
MFR
-
TYS
7h 54m
1 stop
United Airlines Logo
4:56 pm - 9:16 pm
TYS
-
MFR
7h 20m
1 stop
$513United Airlines
Sat, Aug 29 - Tue, Sep 1
Alaska Airlines Logo
6:58 pm - 11:14 am
MFR
-
TYS
13h 16m
2 stops
Alaska Airlines Logo
1:53 pm - 10:55 pm
TYS
-
MFR
12h 02m
2 stops
$523Alaska Airlines
Wed, Aug 19 - Sat, Aug 22
United Airlines Logo
5:00 am - 3:53 pm
MFR
-
TYS
7h 53m
1 stop
United Airlines Logo
4:56 pm - 9:16 pm
TYS
-
MFR
7h 20m
1 stop
$537United Airlines
Sat, May 23 - Fri, May 29

Alaska Airlines flights from Medford to Knoxville

Our best Alaska Airlines deals on Medford to Knoxville flight tickets
Alaska Airlines
May 23
MFR7:08 amMedford
13h 48m
2 stops
TYS11:56 pmKnoxville McGhee Tyson
May 29
TYS1:14 pmKnoxville McGhee Tyson
13h 45m
2 stops
MFR11:59 pmMedford
$483
Alaska Airlines
Aug 19
MFR6:58 pmMedford
13h 16m
2 stops
TYS11:14 amKnoxville McGhee Tyson
Aug 22
TYS1:53 pmKnoxville McGhee Tyson
12h 02m
2 stops
MFR10:55 pmMedford
$523
Alaska Airlines
May 19
MFR5:41 pmMedford
13h 41m
2 stops
TYS10:22 amKnoxville McGhee Tyson
May 23
TYS1:12 pmKnoxville McGhee Tyson
13h 47m
2 stops
MFR11:59 pmMedford
$607

Delta flights from Medford to Knoxville

Our best Delta deals on Medford to Knoxville flight tickets
Delta
May 12
MFR5:25 pmMedford
13h 09m
2 stops
TYS9:34 amKnoxville McGhee Tyson
May 17
TYS5:40 amKnoxville McGhee Tyson
10h 20m
2 stops
MFR1:00 pmMedford
$572
Delta
May 12
MFR5:25 pmMedford
13h 09m
2 stops
TYS9:34 amKnoxville McGhee Tyson
May 16
TYS5:40 amKnoxville McGhee Tyson
10h 20m
2 stops
MFR1:00 pmMedford
$615
Delta
May 13
MFR5:15 amMedford
9h 12m
2 stops
TYS5:27 pmKnoxville McGhee Tyson
May 17
TYS5:40 amKnoxville McGhee Tyson
10h 20m
2 stops
MFR1:00 pmMedford
$729

momondo Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 8/19

1:08 pm-10:38 pm

1 stop6h 30m

Knoxville McGhee Tyson

Sat 8/22

8:48 am-1:00 pm

1 stop7h 12m

$357

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 8/19

6:26 pm-11:17 am

2 stops13h 51m

Knoxville McGhee Tyson

Sat 8/22

8:48 am-1:00 pm

1 stop7h 12m

$404

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 5/23

5:00 am-3:53 pm

1 stop7h 53m

Knoxville McGhee Tyson

Fri 5/29

1:54 pm-10:59 pm

2 stops12h 05m

$464

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/29

1:08 pm-10:38 pm

1 stop6h 30m

Knoxville McGhee Tyson

Tue 9/1

4:56 pm-9:16 pm

1 stop7h 20m

$467

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/29

1:08 pm-10:38 pm

1 stop6h 30m

Knoxville McGhee Tyson

Tue 9/1

7:15 am-5:45 pm

2 stops13h 30m

$472

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/29

6:26 pm-10:08 am

2 stops12h 42m

Knoxville McGhee Tyson

Tue 9/1

7:15 am-5:45 pm

2 stops13h 30m

$477

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 5/23

7:08 am-11:56 pm

2 stops13h 48m

Knoxville McGhee Tyson

Fri 5/29

1:14 pm-11:59 pm

2 stops13h 45m

$483

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 8/29

5:00 am-3:54 pm

1 stop7h 54m

Knoxville McGhee Tyson

Tue 9/1

4:56 pm-9:16 pm

1 stop7h 20m

$513

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 8/19

6:58 pm-11:14 am

2 stops13h 16m

Knoxville McGhee Tyson

Sat 8/22

1:53 pm-10:55 pm

2 stops12h 02m

$523

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Sat 5/23

5:00 am-3:53 pm

1 stop7h 53m

Knoxville McGhee Tyson

Fri 5/29

4:56 pm-9:16 pm

1 stop7h 20m

$537

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 18 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Medford to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Medford and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Medford, with most prices found around $0. If you aren’t able to travel during the month of June, then book flights to Knoxville from Medford during March instead. Flights to Knoxville in March, while not as cheap as those in June, still average around $0.

When to book flights from Medford to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Medford to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medford to Knoxville (MFR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medford to Knoxville

Fastest flight time

6h 31m

Direct flights

None
The fastest flight from Medford to Knoxville takes 6h 31m
There are no direct flights from Medford to Knoxville. There are no popular flight routes from Medford to Knoxville.
Search flight deals

Frequently asked questions about flying from Medford to Knoxville

  • How far is Medford to Knoxville McGhee Tyson by plane?

    Medford and Knoxville McGhee Tyson are 2112.6 mi apart from one another. Typically, this will take 6h 31m by plane in normal conditions.

  • When did momondo last update prices for flights from Medford Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Medford Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Medford Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Medford Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Medford Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Medford to Knoxville?

Best airlines flying from Medford to Knoxville

Compare and see reviews for airlines that fly from Medford to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $317Free CancellationRating
7.4
9,683 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Crossville
Maryville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Medford to Knoxville?

Finding the right flight to Knoxville from Medford is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Medford to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Medford with this policy.

How can momondo help me find flights from Medford to Knoxville?

momondo helps you find the best flight between Medford and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Medford to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Medford. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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