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Cheap flights from Medford to Knoxville from $379

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Medford to Knoxville departing on 12/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Medford to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:05 am - 9:34 pm
MFR
-
TYS
12h 29m
2 stops
Delta Logo
2:30 pm - 11:12 pm
TYS
-
MFR
11h 42m
2 stops
$379Delta
Fri, Dec 4 - Fri, Dec 11
United Airlines Logo
6:28 pm - 11:52 am
MFR
-
TYS
14h 24m
2 stops
United Airlines Logo
4:50 pm - 9:09 pm
TYS
-
MFR
7h 19m
1 stop
$414United Airlines
Fri, Aug 28 - Sat, Sep 5
United Airlines Logo
1:00 pm - 10:29 pm
MFR
-
TYS
6h 29m
1 stop
United Airlines Logo
4:50 pm - 9:09 pm
TYS
-
MFR
7h 19m
1 stop
$442United Airlines
Fri, Aug 28 - Sat, Sep 5
United Airlines Logo
12:45 pm - 10:20 pm
MFR
-
TYS
6h 35m
1 stop
United Airlines Logo
4:25 pm - 9:10 pm
TYS
-
MFR
7h 45m
1 stop
$467United Airlines
Wed, Nov 11 - Sat, Nov 14
United Airlines Logo
5:10 am - 2:36 pm
MFR
-
TYS
6h 26m
1 stop
United Airlines Logo
2:00 pm - 11:09 pm
TYS
-
MFR
12h 09m
2 stops
$472United Airlines
Wed, Nov 11 - Sat, Nov 14
United Airlines Logo
6:34 pm - 10:00 am
MFR
-
TYS
12h 26m
2 stops
United Airlines Logo
2:00 pm - 9:10 pm
TYS
-
MFR
10h 10m
2 stops
$477United Airlines
Wed, Nov 11 - Sat, Nov 14
United Airlines Logo
5:00 am - 3:54 pm
MFR
-
TYS
7h 54m
1 stop
United Airlines Logo
9:00 am - 6:13 pm
TYS
-
MFR
12h 13m
2 stops
$518United Airlines
Mon, Sep 14 - Sat, Sep 19
United Airlines Logo
12:45 pm - 10:20 pm
MFR
-
TYS
6h 35m
1 stop
United Airlines Logo
4:25 pm - 9:10 pm
TYS
-
MFR
7h 45m
1 stop
$519United Airlines
Fri, Dec 4 - Fri, Dec 11
United Airlines Logo
6:28 pm - 9:57 am
MFR
-
TYS
12h 29m
2 stops
United Airlines Logo
9:00 am - 6:13 pm
TYS
-
MFR
12h 13m
2 stops
$523United Airlines
Mon, Sep 14 - Sat, Sep 19
United Airlines Logo
6:34 pm - 10:00 am
MFR
-
TYS
12h 26m
2 stops
United Airlines Logo
4:25 pm - 9:10 pm
TYS
-
MFR
7h 45m
1 stop
$524United Airlines
Fri, Dec 4 - Fri, Dec 11

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American Airlines flights from Medford to Knoxville

Our best American Airlines deals on Medford to Knoxville flight tickets
American Airlines
Aug 28
MFR5:20 amMedford
12h 39m
2 stops
TYS8:59 pmKnoxville McGhee Tyson
Sep 5
TYS11:49 amKnoxville McGhee Tyson
10h 31m
2 stops
MFR7:20 pmMedford
$528
American Airlines
Jul 10
MFR5:15 amMedford
11h 15m
2 stops
TYS7:30 pmKnoxville McGhee Tyson
Jul 17
TYS1:54 pmKnoxville McGhee Tyson
12h 44m
2 stops
MFR11:38 pmMedford
$715
American Airlines
Jun 20
MFR5:15 amMedford
11h 16m
2 stops
TYS7:31 pmKnoxville McGhee Tyson
Jun 29
TYS1:54 pmKnoxville McGhee Tyson
12h 50m
2 stops
MFR11:44 pmMedford
$969

United Airlines flights from Medford to Knoxville

Our best United Airlines deals on Medford to Knoxville flight tickets
United Airlines
Aug 28
MFR6:28 pmMedford
14h 24m
2 stops
TYS11:52 amKnoxville McGhee Tyson
Sep 5
TYS4:50 pmKnoxville McGhee Tyson
7h 19m
1 stop
MFR9:09 pmMedford
$414
United Airlines
Aug 28
MFR1:00 pmMedford
6h 29m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
Sep 5
TYS4:50 pmKnoxville McGhee Tyson
7h 19m
1 stop
MFR9:09 pmMedford
$442
United Airlines
Nov 11
MFR12:45 pmMedford
6h 35m
1 stop
TYS10:20 pmKnoxville McGhee Tyson
Nov 14
TYS4:25 pmKnoxville McGhee Tyson
7h 45m
1 stop
MFR9:10 pmMedford
$467

momondo Fare Finder

 
Customize your flight search to find flights from Medford to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 19, 2026.
Use the filters below to find and compare flights from Medford to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 12/4

6:05 am-9:34 pm

2 stops12h 29m

Knoxville McGhee Tyson

Fri 12/11

2:30 pm-11:12 pm

2 stops11h 42m

$379

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 8/28

6:28 pm-11:52 am

2 stops14h 24m

Knoxville McGhee Tyson

Sat 9/5

4:50 pm-9:09 pm

1 stop7h 19m

$414
Quickest round-trip

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 8/28

1:00 pm-10:29 pm

1 stop6h 29m

Knoxville McGhee Tyson

Sat 9/5

4:50 pm-9:09 pm

1 stop7h 19m

$442

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 11/11

12:45 pm-10:20 pm

1 stop6h 35m

Knoxville McGhee Tyson

Sat 11/14

4:25 pm-9:10 pm

1 stop7h 45m

$467

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 11/11

5:10 am-2:36 pm

1 stop6h 26m

Knoxville McGhee Tyson

Sat 11/14

2:00 pm-11:09 pm

2 stops12h 09m

$472

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Wed 11/11

6:34 pm-10:00 am

2 stops12h 26m

Knoxville McGhee Tyson

Sat 11/14

2:00 pm-9:10 pm

2 stops10h 10m

$477

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Mon 9/14

5:00 am-3:54 pm

1 stop7h 54m

Knoxville McGhee Tyson

Sat 9/19

9:00 am-6:13 pm

2 stops12h 13m

$518

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 12/4

12:45 pm-10:20 pm

1 stop6h 35m

Knoxville McGhee Tyson

Fri 12/11

4:25 pm-9:10 pm

1 stop7h 45m

$519

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Mon 9/14

6:28 pm-9:57 am

2 stops12h 29m

Knoxville McGhee Tyson

Sat 9/19

9:00 am-6:13 pm

2 stops12h 13m

$523

MedfordKnoxville

MFR - TYS

MFRTYS

Medford

Fri 12/4

6:34 pm-10:00 am

2 stops12h 26m

Knoxville McGhee Tyson

Fri 12/11

4:25 pm-9:10 pm

1 stop7h 45m

$524

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 11 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Medford to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of June is, on average, the cheapest month to fly to Knoxville from Medford, with most prices found around $0. If you aren’t able to travel during the month of June, then book flights to Knoxville from Medford during March instead. Flights to Knoxville in March, while not as cheap as those in June, still average around $0.

When to book flights from Medford to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Medford to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Medford to Knoxville (MFR to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Medford to Knoxville

Fastest flight time

6h 09m

Direct flights

None
The fastest flight from Medford to Knoxville takes 6h 09m
There are no direct flights from Medford to Knoxville. There are no popular flight routes from Medford to Knoxville.
Search flight deals

Frequently asked questions about flying from Medford to Knoxville

  • How far is Medford to Knoxville McGhee Tyson by plane?

    Medford and Knoxville McGhee Tyson are 2112.6 mi apart from one another. Typically, this will take 6h 09m by plane in normal conditions.

  • When did momondo last update prices for flights from Medford Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Medford Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Medford Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Medford Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Medford Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Medford to Knoxville?

Best airlines flying from Medford to Knoxville

Compare and see reviews for airlines that fly from Medford to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $317Free CancellationRating
7.4
9,860 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Lenoir City
Kodak
Newport
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Medford to Knoxville?

Finding the right flight to Knoxville from Medford is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Medford to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Medford with this policy.

How can momondo help me find flights from Medford to Knoxville?

momondo helps you find the best flight between Medford and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Medford to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Medford. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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