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Cheap flights from La Crosse to Louisville from $386

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from La Crosse to Louisville departing on 6/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from La Crosse to Louisville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:25 pm - 10:19 pm
LSE
-
SDF
3h 54m
1 stop
American Airlines Logo
11:05 am - 4:52 pm
SDF
-
LSE
6h 47m
1 stop
$460American Airlines
Tue, Jun 23 - Mon, Jun 29
American Airlines Logo
5:25 pm - 10:19 pm
LSE
-
SDF
3h 54m
1 stop
American Airlines Logo
3:22 pm - 12:19 am
SDF
-
LSE
9h 57m
2 stops
$466American Airlines
Tue, Jun 23 - Mon, Jun 29
American Airlines Logo
11:52 am - 11:19 pm
LSE
-
SDF
10h 27m
2 stops
American Airlines Logo
3:22 pm - 12:19 am
SDF
-
LSE
9h 57m
2 stops
$516American Airlines
Tue, Jun 23 - Mon, Jun 29
American Airlines Logo
5:34 pm - 2:16 pm
LSE
-
SDF
19h 42m
1 stop
American Airlines Logo
6:56 pm - 11:14 am
SDF
-
LSE
17h 18m
1 stop
$522American Airlines
Tue, May 26 - Fri, May 29
American Airlines Logo
11:52 am - 12:28 am
LSE
-
SDF
11h 36m
2 stops
American Airlines Logo
1:21 pm - 12:19 am
SDF
-
LSE
11h 58m
2 stops
$548American Airlines
Tue, Jun 23 - Mon, Jun 29
American Airlines Logo
11:52 am - 6:26 pm
LSE
-
SDF
5h 34m
1 stop
American Airlines Logo
6:59 am - 11:22 am
SDF
-
LSE
5h 23m
1 stop
$549American Airlines
Wed, May 27 - Sun, May 31
American Airlines Logo
11:52 am - 11:21 pm
LSE
-
SDF
10h 29m
2 stops
American Airlines Logo
6:59 am - 11:22 am
SDF
-
LSE
5h 23m
1 stop
$555American Airlines
Wed, May 27 - Sun, May 31
American Airlines Logo
11:52 am - 11:21 pm
LSE
-
SDF
10h 29m
2 stops
American Airlines Logo
5:00 am - 11:22 am
SDF
-
LSE
7h 22m
2 stops
$560American Airlines
Wed, May 27 - Sun, May 31
American Airlines Logo
11:52 am - 12:28 am
LSE
-
SDF
11h 36m
2 stops
American Airlines Logo
6:56 pm - 11:14 am
SDF
-
LSE
17h 18m
1 stop
$612American Airlines
Tue, May 26 - Fri, May 29
American Airlines Logo
11:52 am - 12:28 am
LSE
-
SDF
11h 36m
2 stops
American Airlines Logo
3:52 pm - 12:06 am
SDF
-
LSE
9h 14m
2 stops
$954American Airlines
Tue, May 26 - Fri, May 29

American Airlines flights from La Crosse to Louisville

Our best American Airlines deals on La Crosse to Louisville flight tickets
American Airlines
Jun 23
LSE5:25 pmLa Crosse
3h 54m
1 stop
SDF10:19 pmLouisville Intl
Jun 29
SDF11:05 amLouisville Intl
6h 47m
1 stop
LSE4:52 pmLa Crosse
$460
American Airlines
Jun 23
LSE5:25 pmLa Crosse
3h 54m
1 stop
SDF10:19 pmLouisville Intl
Jun 29
SDF3:22 pmLouisville Intl
9h 57m
2 stops
LSE12:19 amLa Crosse
$466
American Airlines
Jun 23
LSE11:52 amLa Crosse
10h 27m
2 stops
SDF11:19 pmLouisville Intl
Jun 29
SDF3:22 pmLouisville Intl
9h 57m
2 stops
LSE12:19 amLa Crosse
$516

momondo Fare Finder

 
Customize your flight search to find flights from La Crosse to Louisville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 13, 2026.
Use the filters below to find and compare flights from La Crosse to Louisville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Tue 6/23

5:25 pm-10:19 pm

1 stop3h 54m

Louisville Intl

Mon 6/29

11:05 am-4:52 pm

1 stop6h 47m

$460

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Tue 6/23

5:25 pm-10:19 pm

1 stop3h 54m

Louisville Intl

Mon 6/29

3:22 pm-12:19 am

2 stops9h 57m

$466

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Tue 6/23

11:52 am-11:19 pm

2 stops10h 27m

Louisville Intl

Mon 6/29

3:22 pm-12:19 am

2 stops9h 57m

$516

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Tue 5/26

5:34 pm-2:16 pm

1 stop19h 42m

Louisville Intl

Fri 5/29

6:56 pm-11:14 am

1 stop17h 18m

$522

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Tue 6/23

11:52 am-12:28 am

2 stops11h 36m

Louisville Intl

Mon 6/29

1:21 pm-12:19 am

2 stops11h 58m

$548

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Wed 5/27

11:52 am-6:26 pm

1 stop5h 34m

Louisville Intl

Sun 5/31

6:59 am-11:22 am

1 stop5h 23m

$549

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Wed 5/27

11:52 am-11:21 pm

2 stops10h 29m

Louisville Intl

Sun 5/31

6:59 am-11:22 am

1 stop5h 23m

$555

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Wed 5/27

11:52 am-11:21 pm

2 stops10h 29m

Louisville Intl

Sun 5/31

5:00 am-11:22 am

2 stops7h 22m

$560

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Tue 5/26

11:52 am-12:28 am

2 stops11h 36m

Louisville Intl

Fri 5/29

6:56 pm-11:14 am

1 stop17h 18m

$612

La CrosseLouisville

LSE - SDF

LSESDF

La Crosse

Tue 5/26

11:52 am-12:28 am

2 stops11h 36m

Louisville Intl

Fri 5/29

3:52 pm-12:06 am

2 stops9h 14m

$954

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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See travel insights to Louisville from

How to get the cheapest flight ticket from La Crosse to Louisville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from La Crosse to Louisville Intl?

American Airlines and Allegiant Air are the most popular carriers operating from La Crosse to Louisville Intl

When to book flights from La Crosse to Louisville

Are you open to changing your travel dates? Check out the ideal times to fly from La Crosse to Louisville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap La Crosse to Louisville (LSE to SDF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from La Crosse to Louisville

Fastest flight time

3h 54m

Direct flights

None
The fastest flight from La Crosse to Louisville takes 3h 54m
There are no direct flights from La Crosse to Louisville. There are no popular flight routes from La Crosse to Louisville.
Search flight deals

Frequently asked questions about flying from La Crosse to Louisville

  • How far is La Crosse to Louisville Intl by plane?

    La Crosse and Louisville Intl are 477.9 mi apart from one another. In terms of flight time, this usually takes a little over 3h 54m.

  • When did momondo last update prices for flights from La Crosse Airport to Louisville Intl Airport?

    Prices for flights from La Crosse Airport to Louisville Intl Airport refresh daily.

  • How old do you have to be to fly from La Crosse Airport to Louisville Intl Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from La Crosse Airport to Louisville Intl Airport.

  • What documentation or ID do you need to fly to Louisville Intl Airport?

    The travel and health documents you'll need for your trip to Louisville Intl Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Louisville Intl Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Traveling to a place near Louisville?

Book flights to Louisville if you plan to visit one of these locations
French Lick
Elizabethtown
Jeffersonville
West Baden Springs
Bardstown
New Albany
Shepherdsville
Brandenburg
Corydon
Elizabeth
Charlestown
Georgetown
Springfield

Why use momondo?

Why should I use momondo to find a flight deal from La Crosse to Louisville?

Finding the right flight to Louisville from La Crosse is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Louisville quick and easy, saving you time and money.

Can I find flights from La Crosse to Louisville with flexible booking policies on momondo?

All flight searches from La Crosse to Louisville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from La Crosse to Louisville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from La Crosse to Louisville.

I’m not ready to book a flight from La Crosse to Louisville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for La Crosse to Louisville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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