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Cheap flights from La Crosse to Charleston from $280

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from La Crosse to Charleston departing on 9/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from La Crosse to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
12:02 pm - 6:42 pmLSE  La Crosse-CHS Charleston
5h 40m1 stop Chicago O'Hare Intl
American Airlines Logo
7:46 pm - 12:20 amCHS  Charleston-LSE La Crosse
5h 34m1 stop Chicago O'Hare Intl
$280American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
12:19 pm - 7:20 pmLSE  La Crosse-CHS Charleston
6h 01m1 stop Chicago O'Hare Intl
American Airlines Logo
7:46 pm - 12:20 amCHS  Charleston-LSE La Crosse
5h 34m1 stop Chicago O'Hare Intl
$280American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
12:02 pm - 6:42 pmLSE  La Crosse-CHS Charleston
5h 40m1 stop Chicago O'Hare Intl
American Airlines Logo
4:08 pm - 12:20 amCHS  Charleston-LSE La Crosse
9h 12m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$286American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
12:19 pm - 9:56 pmLSE  La Crosse-CHS Charleston
8h 37m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
American Airlines Logo
7:18 am - 11:22 amCHS  Charleston-LSE La Crosse
5h 04m1 stop Chicago O'Hare Intl
$286American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
12:02 pm - 6:42 pmLSE  La Crosse-CHS Charleston
5h 40m1 stop Chicago O'Hare Intl
American Airlines Logo
7:46 pm - 12:20 amCHS  Charleston-LSE La Crosse
5h 34m1 stop Chicago O'Hare Intl
$316American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
12:02 pm - 6:42 pmLSE  La Crosse-CHS Charleston
5h 40m1 stop Chicago O'Hare Intl
American Airlines Logo
4:08 pm - 12:20 amCHS  Charleston-LSE La Crosse
9h 12m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$322American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
12:02 pm - 10:08 pmLSE  La Crosse-CHS Charleston
9h 06m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
American Airlines Logo
4:08 pm - 12:20 amCHS  Charleston-LSE La Crosse
9h 12m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$327American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
12:19 pm - 11:00 pmLSE  La Crosse-CHS Charleston
9h 41m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
4:12 pm - 12:20 amCHS  Charleston-LSE La Crosse
9h 08m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$327American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
12:02 pm - 10:08 pmLSE  La Crosse-CHS Charleston
9h 06m2 stops Chicago O'Hare Intl Washington, D.C. Reagan-National
American Airlines Logo
4:08 pm - 12:20 amCHS  Charleston-LSE La Crosse
9h 12m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$344American Airlines
Wed, Sep 16 - Sat, Sep 19
American Airlines Logo
12:02 pm - 6:42 pmLSE  La Crosse-CHS Charleston
5h 40m1 stop Chicago O'Hare Intl
American Airlines Logo
7:18 am - 11:22 amCHS  Charleston-LSE La Crosse
5h 04m1 stop Chicago O'Hare Intl
$355American Airlines
Wed, Sep 23 - Mon, Sep 28

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American Airlines flights from La Crosse to Charleston

Our best American Airlines deals on La Crosse to Charleston flight tickets
American Airlines
Sep 2
LSE12:19 pmLa Crosse
6h 01m
1 stop
CHS7:20 pmCharleston
Sep 9
CHS7:46 pmCharleston
5h 34m
1 stop
LSE12:20 amLa Crosse
$280
American Airlines
Sep 2
LSE12:19 pmLa Crosse
8h 37m
2 stops
CHS9:56 pmCharleston
Sep 9
CHS7:18 amCharleston
5h 04m
1 stop
LSE11:22 amLa Crosse
$286
American Airlines
Sep 16
LSE12:02 pmLa Crosse
5h 40m
1 stop
CHS6:42 pmCharleston
Sep 19
CHS7:46 pmCharleston
5h 34m
1 stop
LSE12:20 amLa Crosse
$316

momondo Fare Finder

 
Customize your flight search to find flights from La Crosse to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from La Crosse to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/16

12:02 pm-6:42 pm

1 stop5h 40m

Charleston

Sat 9/19

7:46 pm-12:20 am

1 stop5h 34m

$280

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/2

12:19 pm-7:20 pm

1 stop6h 01m

Charleston

Wed 9/9

7:46 pm-12:20 am

1 stop5h 34m

$280

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/16

12:02 pm-6:42 pm

1 stop5h 40m

Charleston

Sat 9/19

4:08 pm-12:20 am

2 stops9h 12m

$286

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/2

12:19 pm-9:56 pm

2 stops8h 37m

Charleston

Wed 9/9

7:18 am-11:22 am

1 stop5h 04m

$286

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/16

12:02 pm-6:42 pm

1 stop5h 40m

Charleston

Sat 9/19

7:46 pm-12:20 am

1 stop5h 34m

$316

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/16

12:02 pm-6:42 pm

1 stop5h 40m

Charleston

Sat 9/19

4:08 pm-12:20 am

2 stops9h 12m

$322

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/16

12:02 pm-10:08 pm

2 stops9h 06m

Charleston

Sat 9/19

4:08 pm-12:20 am

2 stops9h 12m

$327

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/2

12:19 pm-11:00 pm

2 stops9h 41m

Charleston

Wed 9/9

4:12 pm-12:20 am

2 stops9h 08m

$327

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/16

12:02 pm-10:08 pm

2 stops9h 06m

Charleston

Sat 9/19

4:08 pm-12:20 am

2 stops9h 12m

$344
Quickest round-trip

La CrosseCharleston

LSE La Crosse - CHS Charleston

LSECHS

La Crosse

Wed 9/23

12:02 pm-6:42 pm

1 stop5h 40m

Charleston

Mon 9/28

7:18 am-11:22 am

1 stop5h 04m

$355

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Charleston from

How to get the cheapest flight ticket from La Crosse to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Charleston?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Charleston from La Crosse according to our data. American Airlines is the first choice among our users, with 80% of people opting to fly with this airline when traveling to Charleston. Keep in mind that there are 3 different airlines that fly to Charleston on a routine basis, so you have a few additional options to choose from.

When to book flights from La Crosse to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from La Crosse to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap La Crosse to Charleston (LSE to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from La Crosse to Charleston

Fastest flight time

5h 40m

Direct flights

None
The fastest flight from La Crosse to Charleston takes 5h 40m
There are no direct flights from La Crosse to Charleston. There are no popular flight routes from La Crosse to Charleston.
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Frequently asked questions about flying from La Crosse to Charleston

  • How far is La Crosse to Charleston by plane?

    Charleston is 975.3 mi away from La Crosse. In terms of flight time, this usually takes a little over 5h 40m.

  • When did momondo last update prices for flights from La Crosse Airport to Charleston Airport?

    Prices for flights from La Crosse Airport to Charleston Airport are updated daily.

  • How many operators does momondo search for flights from La Crosse Airport to Charleston Airport?

  • How old do you have to be to fly from La Crosse Airport to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from La Crosse Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The necessary travel and health documents for your Charleston Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from La Crosse to Charleston?

Best airlines flying from La Crosse to Charleston

Compare and see reviews for airlines that fly from La Crosse to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $299Free CancellationRating
7.1
11,852 reviews
Search American Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
North Charleston
Summerville
Isle of Palms
Mount Pleasant
Kiawah Island
Walterboro
Goose Creek
Santee
Edisto Island
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from La Crosse to Charleston?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from La Crosse to Charleston. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from La Crosse to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for La Crosse to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from La Crosse to Charleston?

momondo helps you find the best flight between La Crosse and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from La Crosse to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from La Crosse are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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