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Cheap flights from Knoxville to South Carolina from $94

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to South Carolina departing on 9/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to South Carolina

Cheap round-trip flights

Logo
8:32 pm - 9:22 amTYS-CLT
36h 50m2 stops
Logo
8:51 pm - 10:35 amCLT-TYS
13h 44m1 stop
$204
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Mon, Sep 15 - Mon, Sep 22
Logo
7:15 am - 4:13 pmTYS-CHS
8h 58m1 stop
Logo
10:31 am - 10:33 amCHS-TYS
24h 02m1 stop
$207
Find Deal
Fri, Oct 31 - Mon, Nov 3
American Airlines Logo
5:08 pm - 8:05 amTYS-CLT
14h 57m1 stop
American Airlines Logo
11:05 am - 12:27 pmCLT-TYS
1h 22mnonstop
$220American Airlines
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Fri, Oct 24 - Sat, Oct 25
American Airlines Logo
7:45 pm - 11:08 pmTYS-MYR
3h 23m1 stop
American Airlines Logo
7:36 pm - 11:03 pmMYR-TYS
3h 27m1 stop
$229American Airlines
Find Deal
Sat, Sep 20 - Mon, Sep 22
Delta Logo
8:10 pm - 11:59 pmTYS-MYR
3h 49m1 stop
Delta Logo
6:58 pm - 11:46 pmMYR-TYS
4h 48m1 stop
$249Delta
Find Deal
Mon, Oct 6 - Mon, Oct 13
Allegiant Air Logo
9:15 pm - 10:12 amTYS-SAV
12h 57m1 stop
Allegiant Air Logo
8:00 am - 10:03 amSAV-TYS
26h 03m1 stop
$275Allegiant Air
Find Deal
Sun, Oct 26 - Fri, Oct 31
Allegiant Air Logo
9:15 pm - 10:12 amTYS-SAV
12h 57m1 stop
Allegiant Air Logo
9:24 am - 10:03 amSAV-TYS
24h 39m2 stops
$293Allegiant Air
Find Deal
Sun, Oct 26 - Fri, Oct 31
Delta Logo
11:20 am - 4:32 pmTYS-SAV
5h 12m1 stop
Delta Logo
5:30 am - 11:05 amSAV-TYS
5h 35m1 stop
$297Delta
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Sat, Nov 15 - Tue, Nov 18
United Airlines Logo
7:00 am - 2:42 pmTYS-MYR
7h 42m1 stop
United Airlines Logo
2:47 pm - 10:28 amMYR-TYS
19h 41m1 stop
$388United Airlines
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Tue, Sep 9 - Fri, Sep 12
United Airlines Logo
7:00 am - 2:42 pmTYS-MYR
7h 42m1 stop
United Airlines Logo
2:47 pm - 8:56 pmMYR-TYS
6h 09m1 stop
$392United Airlines
Find Deal
Tue, Sep 2 - Sat, Sep 6

American Airlines flights from Knoxville to South Carolina

Our best American Airlines deals on Knoxville to South Carolina flight tickets
American Airlines
Oct 24
TYS5:08 pmKnoxville McGhee Tyson
14h 57m
1 stop
CLT8:05 amCharlotte Douglas
Oct 25
CLT11:05 amCharlotte Douglas
1h 22m
TYS12:27 pmKnoxville McGhee Tyson
$220
Find similar
American Airlines
Sep 20
TYS7:45 pmKnoxville McGhee Tyson
3h 23m
1 stop
MYR11:08 pmMyrtle Beach Intl
Sep 22
MYR7:36 pmMyrtle Beach Intl
3h 27m
1 stop
TYS11:03 pmKnoxville McGhee Tyson
$229
Find similar
American Airlines
Sep 2
TYS7:35 pmKnoxville McGhee Tyson
3h 36m
1 stop
MYR11:11 pmMyrtle Beach Intl
Sep 9
MYR8:06 amMyrtle Beach Intl
5h 37m
1 stop
TYS1:43 pmKnoxville McGhee Tyson
$234
Find similar

Delta flights from Knoxville to South Carolina

Our best Delta deals on Knoxville to South Carolina flight tickets
Delta
Oct 6
TYS8:10 pmKnoxville McGhee Tyson
3h 49m
1 stop
MYR11:59 pmMyrtle Beach Intl
Oct 13
MYR6:58 pmMyrtle Beach Intl
4h 48m
1 stop
TYS11:46 pmKnoxville McGhee Tyson
$249
Find similar
Delta
Nov 15
TYS11:20 amKnoxville McGhee Tyson
5h 12m
1 stop
SAV4:32 pmSavannah/Hilton Head
Nov 18
SAV5:30 amSavannah/Hilton Head
5h 35m
1 stop
TYS11:05 amKnoxville McGhee Tyson
$297
Find similar
Delta
Sep 16
TYS12:01 pmKnoxville McGhee Tyson
3h 37m
1 stop
CHS3:38 pmCharleston
Sep 23
CHS8:02 amCharleston
2h 54m
1 stop
TYS10:56 amKnoxville McGhee Tyson
$307
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 9/15

8:32 pm-9:22 am

2 stops36h 50m

Charlotte Douglas

Mon 9/22

8:51 pm-10:35 am

1 stop13h 44m

$204

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 10/31

7:15 am-4:13 pm

1 stop8h 58m

Charleston

Mon 11/3

10:31 am-10:33 am

1 stop24h 02m

$207

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 10/24

5:08 pm-8:05 am

1 stop14h 57m

Charlotte Douglas

Sat 10/25

11:05 am-12:27 pm

Nonstop1h 22m

$220

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 9/20

7:45 pm-11:08 pm

1 stop3h 23m

Myrtle Beach Intl

Mon 9/22

7:36 pm-11:03 pm

1 stop3h 27m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 10/6

8:10 pm-11:59 pm

1 stop3h 49m

Myrtle Beach Intl

Mon 10/13

6:58 pm-11:46 pm

1 stop4h 48m

$249

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Sun 10/26

9:15 pm-10:12 am

1 stop12h 57m

Savannah/Hilton Head

Fri 10/31

8:00 am-10:03 am

1 stop26h 03m

$275

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Sun 10/26

9:15 pm-10:12 am

1 stop12h 57m

Savannah/Hilton Head

Fri 10/31

9:24 am-10:03 am

2 stops24h 39m

$293

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Sat 11/15

11:20 am-4:32 pm

1 stop5h 12m

Savannah/Hilton Head

Tue 11/18

5:30 am-11:05 am

1 stop5h 35m

$297

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 9/9

7:00 am-2:42 pm

1 stop7h 42m

Myrtle Beach Intl

Fri 9/12

2:47 pm-10:28 am

1 stop19h 41m

$388

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 9/2

7:00 am-2:42 pm

1 stop7h 42m

Myrtle Beach Intl

Sat 9/6

2:47 pm-8:56 pm

1 stop6h 09m

$392

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Knoxville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Knoxville is in August. Flight prices, which tend to average around $320, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Knoxville during May instead. Flights to South Carolina in May, while not as cheap as those in August, still average around $366.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Saturday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $456. The most expensive day to fly to South Carolina is Monday, with ticket prices averaging around $678.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Knoxville to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $478. Try not to purchase tickets in the afternoon because they tend to be around $588. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Knoxville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South Carolina

Fastest flight time

1h 10m

Direct flights

Every day

Airports in South Carolina

1 airport
The fastest flight from Knoxville to South Carolina takes 1h 10m
Direct flights go from Knoxville to South Carolina every day.
There is 1 airport near South Carolina: Charlotte Douglas (CLT)
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?

    Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to South Carolina

Compare and see reviews for airlines that fly from Knoxville to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $218Free CancellationRating
7.9
7,982 reviews
Search Delta flights
American AirlinesPriceFrom $228Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South Carolina?

It is quick and easy to find Knoxville to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Knoxville to South Carolina with flexible booking policies on momondo?

All flight searches from Knoxville to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to South Carolina.

I’m not ready to book a flight from Knoxville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

An easier way to manage your South Carolina trip

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