How many flights depart from Knoxville to South Carolina on average per week?

As of April 2026, 69 flights take off from Knoxville and land in South Carolina each week. The most common flight departure day for this route is Mon, with 14% of weekly flights taking off on this day.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?

Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?

There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of April 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$98 Cheap Flights from Knoxville to South Carolina in 2026

1 adult

0 bags

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Find the cheapest flights from Knoxville to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

6:20 pm - 6:52 pm

TYS

CLT

24h 32m

1 stop

9:07 pm - 11:06 am

CLT

TYS

13h 59m

1 stop

$182Multiple Airlines

Mon, May 4 - Fri, May 8

6:20 pm - 4:35 pm

TYS

CLT

22h 15m

1 stop

9:07 pm - 11:06 am

CLT

TYS

13h 59m

1 stop

$198Multiple Airlines

Fri, May 1 - Fri, May 8

6:05 pm - 10:54 pm

TYS

CHS

4h 49m

1 stop

7:41 pm - 10:58 pm

CHS

TYS

3h 17m

1 stop

$221American Airlines

Tue, Aug 11 - Tue, Aug 18

8:00 am - 12:35 pm

TYS

CHS

4h 35m

1 stop

7:35 am - 6:55 pm

CHS

TYS

11h 20m

2 stops

$228Southwest

Tue, Aug 11 - Tue, Aug 18

8:00 am - 7:45 pm

TYS

CHS

11h 45m

2 stops

6:45 am - 2:20 pm

CHS

TYS

7h 35m

2 stops

$239Southwest

Tue, Aug 11 - Tue, Aug 18

7:33 pm - 11:40 pm

TYS

SAV

4h 07m

1 stop

5:30 am - 9:34 am

SAV

TYS

4h 04m

1 stop

$295Delta

Mon, May 11 - Mon, May 18

5:59 pm - 9:00 pm

TYS

SAV

3h 01m

1 stop

7:59 pm - 11:56 pm

SAV

TYS

3h 57m

1 stop

$299Delta

Mon, May 11 - Mon, May 18

7:59 pm - 11:59 pm

TYS

SAV

4h 00m

1 stop

6:26 pm - 11:59 pm

SAV

TYS

5h 33m

1 stop

$337American Airlines

Fri, Jun 5 - Mon, Jun 8

9:50 am - 11:59 pm

TYS

CAE

14h 09m

1 stop

7:45 pm - 10:42 am

CAE

TYS

14h 57m

1 stop

$678United Airlines

Tue, May 19 - Sun, May 24

7:18 pm - 1:39 pm

TYS

CAE

18h 21m

2 stops

7:45 pm - 10:42 am

CAE

TYS

14h 57m

1 stop

$693United Airlines

Tue, May 19 - Sun, May 24

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American Airlines flights from Knoxville to South Carolina

Our best American Airlines deals on Knoxville to South Carolina flight tickets

American Airlines

Aug 11

TYS6:05 pmKnoxville McGhee Tyson

4h 49m

1 stop

CHS10:54 pmCharleston

Aug 18

CHS7:41 pmCharleston

3h 17m

1 stop

TYS10:58 pmKnoxville McGhee Tyson

$221

American Airlines

May 16

TYS5:37 amKnoxville McGhee Tyson

26h 48m

1 stop

CLT8:25 amCharlotte Douglas

May 17

CLT9:50 amCharlotte Douglas

1h 25m

TYS11:15 amKnoxville McGhee Tyson

$277

American Airlines

Jun 2

TYS5:00 amKnoxville McGhee Tyson

3h 44m

1 stop

MYR8:44 amMyrtle Beach Intl

Jun 9

MYR6:06 pmMyrtle Beach Intl

5h 41m

1 stop

TYS11:47 pmKnoxville McGhee Tyson

$336

Southwest flights from Knoxville to South Carolina

Our best Southwest deals on Knoxville to South Carolina flight tickets

Southwest

Aug 11

TYS8:00 amKnoxville McGhee Tyson

4h 35m

1 stop

CHS12:35 pmCharleston

Aug 18

CHS7:35 amCharleston

11h 20m

2 stops

TYS6:55 pmKnoxville McGhee Tyson

$228

Southwest

Aug 11

TYS8:00 amKnoxville McGhee Tyson

11h 45m

2 stops

CHS7:45 pmCharleston

Aug 18

CHS6:45 amCharleston

7h 35m

2 stops

TYS2:20 pmKnoxville McGhee Tyson

$239

Southwest

Aug 26

TYS8:00 amKnoxville McGhee Tyson

5h 50m

1 stop

MYR1:50 pmMyrtle Beach Intl

Aug 31

MYR2:30 pmMyrtle Beach Intl

4h 05m

1 stop

TYS6:35 pmKnoxville McGhee Tyson

$243

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 5/4

6:20 pm-6:52 pm

1 stop24h 32m

Charlotte Douglas

Fri 5/8

9:07 pm-11:06 am

1 stop13h 59m

$182

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 5/1

6:20 pm-4:35 pm

1 stop22h 15m

Charlotte Douglas

Fri 5/8

9:07 pm-11:06 am

1 stop13h 59m

$198

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 8/11

6:05 pm-10:54 pm

1 stop4h 49m

Charleston

Tue 8/18

7:41 pm-10:58 pm

1 stop3h 17m

$221

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 8/11

8:00 am-12:35 pm

1 stop4h 35m

Charleston

Tue 8/18

7:35 am-6:55 pm

2 stops11h 20m

$228

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 8/11

8:00 am-7:45 pm

2 stops11h 45m

Charleston

Tue 8/18

6:45 am-2:20 pm

2 stops7h 35m

$239

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Mon 5/11

7:33 pm-11:40 pm

1 stop4h 07m

Savannah/Hilton Head

Mon 5/18

5:30 am-9:34 am

1 stop4h 04m

$295

Quickest round-trip

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Mon 5/11

5:59 pm-9:00 pm

1 stop3h 01m

Savannah/Hilton Head

Mon 5/18

7:59 pm-11:56 pm

1 stop3h 57m

$299

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Fri 6/5

7:59 pm-11:59 pm

1 stop4h 00m

Savannah/Hilton Head

Mon 6/8

6:26 pm-11:59 pm

1 stop5h 33m

$337

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Tue 5/19

9:50 am-11:59 pm

1 stop14h 09m

Columbia Metropolitan

Sun 5/24

7:45 pm-10:42 am

1 stop14h 57m

$678

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Tue 5/19

7:18 pm-1:39 pm

2 stops18h 21m

Columbia Metropolitan

Sun 5/24

7:45 pm-10:42 am

1 stop14h 57m

$693

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Airlines

Other information

What is the cheapest airline that flies from Knoxville McGhee Tyson to South Carolina?

Southwest, Allegiant Air, and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to South Carolina

Cheap Knoxville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South Carolina

Fastest flight time	2h 59m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Knoxville to South Carolina takes 2h 59m

Direct flights go from Knoxville to South Carolina every day.

There are 57 airports in South Carolina. From Knoxville there are direct flights to Charlotte Douglas (CLT).

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Frequently asked questions about flying from Knoxville to South Carolina

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?
Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?
There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of April 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to South Carolina

Compare and see reviews for airlines that fly from Knoxville to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $125	Free Cancellation	Rating 7.9 8,430 reviews		Search Delta flights
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.1 11,647 reviews		Search American Airlines flights

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Why should I use momondo to find a flight deal from Knoxville to South Carolina?

It is quick and easy to find Knoxville to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Knoxville to South Carolina with flexible booking policies on momondo?

All flight searches from Knoxville to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

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I’m not ready to book a flight from Knoxville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.