What is the cheapest airline that flies from Knoxville McGhee Tyson to South Carolina?

Southwest, Delta, and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to South Carolina

How many flights depart from Knoxville to South Carolina on average per week?

As of September 2026, 50 flights take off from Knoxville and land in South Carolina each week. The most common flight departure day for this route is Wed, with 20% of weekly flights taking off on this day.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?

Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?

There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of September 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$121 Cheap Flights from Knoxville to South Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:55 am - 7:28 amTYS Knoxville McGhee Tyson-CLT Charlotte Douglas

20h 33m1 stop Washington, D.C. Reagan-National

7:32 am - 8:48 amCLT Charlotte Douglas-TYS Knoxville McGhee Tyson

1h 16mnonstop

$230American Airlines

Sat, Oct 31 - Sun, Nov 1

6:20 am - 12:21 pmTYS Knoxville McGhee Tyson-SAV Savannah/Hilton Head

6h 01m1 stop Charlotte Douglas

5:32 pm - 10:54 pmSAV Savannah/Hilton Head-TYS Knoxville McGhee Tyson

5h 22m1 stop Charlotte Douglas

$257American Airlines

Tue, Oct 6 - Tue, Oct 13

8:20 am - 3:20 pmTYS Knoxville McGhee Tyson-SAV Savannah/Hilton Head

7h 00m1 stop Baltimore/Washington

11:40 am - 9:05 pmSAV Savannah/Hilton Head-TYS Knoxville McGhee Tyson

9h 25m2 stops Baltimore/Washington Nashville Intl

$262Southwest

Wed, Oct 21 - Wed, Oct 28

8:20 am - 3:20 pmTYS Knoxville McGhee Tyson-SAV Savannah/Hilton Head

7h 00m1 stop Baltimore/Washington

11:40 am - 8:10 pmSAV Savannah/Hilton Head-TYS Knoxville McGhee Tyson

8h 30m1 stop Baltimore/Washington

$262Southwest

Wed, Oct 21 - Wed, Oct 28

5:40 am - 10:07 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

4h 27m1 stop Atlanta Hartsfield-Jackson

6:58 pm - 11:58 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

5h 00m1 stop Atlanta Hartsfield-Jackson

$273Delta

Sat, Oct 17 - Mon, Oct 19

3:46 pm - 9:26 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

5h 40m1 stop Charlotte Douglas

7:29 pm - 10:54 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 25m1 stop Charlotte Douglas

$273American Airlines

Tue, Oct 6 - Tue, Oct 13

9:28 pm - 9:13 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

11h 45m1 stop Fort Lauderdale

4:03 pm - 10:05 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

18h 02m1 stop Fort Lauderdale

$277Multiple Airlines

Fri, Oct 23 - Tue, Oct 27

7:58 pm - 11:47 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

3h 49m1 stop Charlotte Douglas

8:12 pm - 11:55 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 43m1 stop Charlotte Douglas

$281American Airlines

Fri, Oct 23 - Mon, Oct 26

4:01 pm - 10:02 pmTYS Knoxville McGhee Tyson-CHS Charleston

6h 01m1 stop Atlanta Hartsfield-Jackson

8:08 am - 1:49 pmCHS Charleston-TYS Knoxville McGhee Tyson

5h 41m1 stop Atlanta Hartsfield-Jackson

$305Delta

Fri, Dec 4 - Fri, Dec 11

5:40 am - 10:07 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

4h 27m1 stop Atlanta Hartsfield-Jackson

6:58 pm - 10:22 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 24m1 stop Atlanta Hartsfield-Jackson

$310Delta

Wed, Oct 7 - Wed, Oct 14

Cheap last minute flights

Enter your travel dates to find the best prices.

6:55 pm - 1:00 pmTYS Knoxville McGhee Tyson-SAV Savannah/Hilton Head

18h 05m1 stop Fort Lauderdale

12:23 pm - 10:04 amSAV Savannah/Hilton Head-TYS Knoxville McGhee Tyson

21h 41m1 stop Fort Lauderdale

$356Multiple Airlines

Sat, Sep 12 - Sat, Sep 19

5:40 pm - 3:17 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

21h 37m1 stop Fort Lauderdale

2:41 pm - 8:39 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

5h 58m1 stop Orlando

$374Multiple Airlines

Mon, Sep 14 - Mon, Sep 21

8:20 am - 8:50 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

24h 30m1 stop Orlando

9:15 am - 10:04 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

24h 49m1 stop Fort Lauderdale

$410Multiple Airlines

Fri, Sep 11 - Sat, Sep 19

12:11 pm - 6:23 amTYS Knoxville McGhee Tyson-CLT Charlotte Douglas

42h 12m1 stop Washington, D.C. Reagan-National

8:30 am - 9:44 amCLT Charlotte Douglas-TYS Knoxville McGhee Tyson

1h 14mnonstop

$411American Airlines

Sat, Sep 12 - Mon, Sep 14

8:20 am - 8:50 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

24h 30m1 stop Orlando

5:58 pm - 10:04 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

16h 06m2 stops Tampa Fort Lauderdale

$415Multiple Airlines

Fri, Sep 11 - Sat, Sep 19

6:15 am - 9:43 amTYS Knoxville McGhee Tyson-SAV Savannah/Hilton Head

3h 28m1 stop Charlotte Douglas

4:15 pm - 9:06 pmSAV Savannah/Hilton Head-TYS Knoxville McGhee Tyson

4h 51m1 stop Charlotte Douglas

$481American Airlines

Tue, Sep 15 - Tue, Sep 22

8:18 am - 1:49 pmTYS Knoxville McGhee Tyson-SAV Savannah/Hilton Head

5h 31m1 stop Charlotte Douglas

5:32 pm - 10:50 pmSAV Savannah/Hilton Head-TYS Knoxville McGhee Tyson

5h 18m1 stop Charlotte Douglas

$515American Airlines

Wed, Sep 16 - Sat, Sep 19

5:40 am - 9:11 amTYS Knoxville McGhee Tyson-SAV Savannah/Hilton Head

3h 31m1 stop Atlanta Hartsfield-Jackson

5:00 pm - 10:27 pmSAV Savannah/Hilton Head-TYS Knoxville McGhee Tyson

5h 27m1 stop Atlanta Hartsfield-Jackson

$537Delta

Sun, Sep 13 - Sat, Sep 19

10:12 am - 1:45 pmTYS Knoxville McGhee Tyson-HHH Hilton Head Island

3h 33m1 stop Charlotte Douglas

1:03 pm - 5:37 pmHHH Hilton Head Island-TYS Knoxville McGhee Tyson

4h 34m1 stop Charlotte Douglas

$587American Airlines

Fri, Sep 11 - Sun, Sep 13

11:40 am - 3:22 pmTYS Knoxville McGhee Tyson-CHS Charleston

3h 42m1 stop Atlanta Hartsfield-Jackson

2:32 pm - 8:15 pmCHS Charleston-TYS Knoxville McGhee Tyson

5h 43m1 stop Atlanta Hartsfield-Jackson

$622Delta

Fri, Sep 11 - Sat, Sep 19

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American Airlines flights from Knoxville to South Carolina

Our best American Airlines deals on Knoxville to South Carolina flight tickets

American Airlines

Oct 31

TYS10:55 amKnoxville McGhee Tyson

20h 33m

1 stop

CLT7:28 amCharlotte Douglas

Nov 1

CLT7:32 amCharlotte Douglas

1h 16m

TYS8:48 amKnoxville McGhee Tyson

$230

American Airlines

Oct 6

TYS6:20 amKnoxville McGhee Tyson

6h 01m

1 stop

SAV12:21 pmSavannah/Hilton Head

Oct 13

SAV5:32 pmSavannah/Hilton Head

5h 22m

1 stop

TYS10:54 pmKnoxville McGhee Tyson

$257

American Airlines

Oct 6

TYS3:46 pmKnoxville McGhee Tyson

5h 40m

1 stop

MYR9:26 pmMyrtle Beach Intl

Oct 13

MYR7:29 pmMyrtle Beach Intl

3h 25m

1 stop

TYS10:54 pmKnoxville McGhee Tyson

$273

Southwest flights from Knoxville to South Carolina

Our best Southwest deals on Knoxville to South Carolina flight tickets

Southwest

Oct 21

TYS8:20 amKnoxville McGhee Tyson

7h 00m

1 stop

SAV3:20 pmSavannah/Hilton Head

Oct 28

SAV11:40 amSavannah/Hilton Head

8h 30m

1 stop

TYS8:10 pmKnoxville McGhee Tyson

$262

Southwest

Oct 21

TYS7:15 amKnoxville McGhee Tyson

8h 05m

2 stops

SAV3:20 pmSavannah/Hilton Head

Oct 28

SAV11:40 amSavannah/Hilton Head

9h 25m

2 stops

TYS9:05 pmKnoxville McGhee Tyson

$283

Southwest

Nov 13

TYS7:25 pmKnoxville McGhee Tyson

14h 40m

2 stops

CHS10:05 amCharleston

Nov 17

CHS1:30 pmCharleston

7h 15m

1 stop

TYS8:45 pmKnoxville McGhee Tyson

$292

momondo Fare Finder

Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharlotte

TYS Knoxville McGhee Tyson - CLT Charlotte Douglas

TYSCLT

Knoxville McGhee Tyson

Sat 10/31

10:55 am-7:28 am

1 stop20h 33m

Charlotte Douglas

Sun 11/1

7:32 am-8:48 am

Nonstop1h 16m

$230

KnoxvilleSavannah

TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head

TYSSAV

Knoxville McGhee Tyson

Tue 10/6

6:20 am-12:21 pm

1 stop6h 01m

Savannah/Hilton Head

Tue 10/13

5:32 pm-10:54 pm

1 stop5h 22m

$257

KnoxvilleSavannah

TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head

TYSSAV

Knoxville McGhee Tyson

Wed 10/21

8:20 am-3:20 pm

1 stop7h 00m

Savannah/Hilton Head

Wed 10/28

11:40 am-9:05 pm

2 stops9h 25m

$262

KnoxvilleSavannah

TYS Knoxville McGhee Tyson - SAV Savannah/Hilton Head

TYSSAV

Knoxville McGhee Tyson

Wed 10/21

8:20 am-3:20 pm

1 stop7h 00m

Savannah/Hilton Head

Wed 10/28

11:40 am-8:10 pm

1 stop8h 30m

$262

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Sat 10/17

5:40 am-10:07 am

1 stop4h 27m

Myrtle Beach Intl

Mon 10/19

6:58 pm-11:58 pm

1 stop5h 00m

$273

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Tue 10/6

3:46 pm-9:26 pm

1 stop5h 40m

Myrtle Beach Intl

Tue 10/13

7:29 pm-10:54 pm

1 stop3h 25m

$273

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Fri 10/23

9:28 pm-9:13 am

1 stop11h 45m

Myrtle Beach Intl

Tue 10/27

4:03 pm-10:05 am

1 stop18h 02m

$277

Quickest round-trip

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Fri 10/23

7:58 pm-11:47 pm

1 stop3h 49m

Myrtle Beach Intl

Mon 10/26

8:12 pm-11:55 pm

1 stop3h 43m

$281

KnoxvilleCharleston

TYS Knoxville McGhee Tyson - CHS Charleston

TYSCHS

Knoxville McGhee Tyson

Fri 12/4

4:01 pm-10:02 pm

1 stop6h 01m

Charleston

Fri 12/11

8:08 am-1:49 pm

1 stop5h 41m

$305

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Wed 10/7

5:40 am-10:07 am

1 stop4h 27m

Myrtle Beach Intl

Wed 10/14

6:58 pm-10:22 pm

1 stop3h 24m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Knoxville is in August. Flight prices, which tend to average around $336, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Knoxville during July instead. Flights to South Carolina in July, while not as cheap as those in August, still average around $339.

Cheap Knoxville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South Carolina

Best Price Found	$121
Fastest flight time	1h 25m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Knoxville in the past 72 hours is $121. The best round-trip flight deal from Knoxville to South Carolina found on momondo in the last 72 hours is $230.

The fastest flight from Knoxville to South Carolina takes 1h 25m

Direct flights go from Knoxville to South Carolina every day.

There are 57 airports in South Carolina. From Knoxville there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Knoxville to South Carolina

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?
Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?
There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of September 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to South Carolina

Compare and see reviews for airlines that fly from Knoxville to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $236	Free Cancellation	Rating 7.8 8,554 reviews		Search Delta flights
American Airlines	PriceFrom $275	Free Cancellation	Rating 7.1 12,045 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South Carolina?

It is quick and easy to find Knoxville to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Knoxville to South Carolina with flexible booking policies on momondo?

All flight searches from Knoxville to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to South Carolina.

I’m not ready to book a flight from Knoxville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.