What is the cheapest airline that flies from Knoxville McGhee Tyson to South Carolina?

Southwest, Allegiant Air, and Delta are the most popular carriers operating from Knoxville McGhee Tyson to South Carolina

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?

Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?

There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of October 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$120 Cheap Flights from Knoxville to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:14 pm - 10:28 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

3h 14m1 stop Charlotte Douglas

5:06 pm - 8:46 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 40m1 stop Charlotte Douglas

$239American Airlines

Wed, Feb 3 - Sat, Feb 6

6:00 am - 10:08 amTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

4h 08m1 stop Atlanta Hartsfield-Jackson

6:00 am - 11:06 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

5h 06m1 stop Atlanta Hartsfield-Jackson

$239Delta

Tue, Jan 5 - Sat, Jan 9

5:40 am - 10:15 amTYS Knoxville McGhee Tyson-CHS Charleston

4h 35m1 stop Atlanta Hartsfield-Jackson

5:10 am - 10:01 amCHS Charleston-TYS Knoxville McGhee Tyson

4h 51m1 stop Atlanta Hartsfield-Jackson

$251Delta

Tue, Dec 1 - Tue, Dec 8

9:28 pm - 2:42 pmTYS Knoxville McGhee Tyson-GSP Greenville

17h 14m1 stop Tampa St. Petersburg

2:42 pm - 5:18 pmGSP Greenville-TYS Knoxville McGhee Tyson

26h 36m1 stop Fort Lauderdale

$252Multiple Airlines

Thu, Nov 5 - Mon, Nov 9

7:55 am - 12:45 pmTYS Knoxville McGhee Tyson-CHS Charleston

4h 50m1 stop Baltimore/Washington

8:00 am - 7:50 pmCHS Charleston-TYS Knoxville McGhee Tyson

11h 50m2 stops Chicago Midway Nashville Intl

$256Southwest

Tue, Dec 1 - Tue, Dec 8

9:28 pm - 2:42 pmTYS Knoxville McGhee Tyson-GSP Greenville

17h 14m1 stop Tampa St. Petersburg

8:52 pm - 5:18 pmGSP Greenville-TYS Knoxville McGhee Tyson

20h 26m2 stops Tampa Fort Lauderdale

$275Multiple Airlines

Thu, Nov 5 - Mon, Nov 9

4:12 pm - 9:05 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

4h 53m1 stop Charlotte Douglas

5:03 pm - 8:43 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 40m1 stop Charlotte Douglas

$329American Airlines

Sat, Nov 14 - Wed, Nov 18

10:20 am - 3:53 pmTYS Knoxville McGhee Tyson-HHH Hilton Head Island

5h 33m1 stop Charlotte Douglas

12:33 pm - 4:43 pmHHH Hilton Head Island-TYS Knoxville McGhee Tyson

4h 10m1 stop Charlotte Douglas

$351American Airlines

Wed, Dec 2 - Wed, Dec 9

6:38 am - 12:15 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

5h 37m1 stop Charlotte Douglas

1:50 pm - 6:42 pmMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

4h 52m1 stop Charlotte Douglas

$353American Airlines

Sat, Jan 2 - Sat, Jan 9

2:25 pm - 5:55 pmTYS Knoxville McGhee Tyson-MYR Myrtle Beach Intl

3h 30m1 stop Atlanta Hartsfield-Jackson

6:00 am - 9:12 amMYR Myrtle Beach Intl-TYS Knoxville McGhee Tyson

3h 12m1 stop Atlanta Hartsfield-Jackson

$367Delta

Sun, Mar 7 - Thu, Mar 11

Cheap last minute flights

Enter your travel dates to find the best prices.

2:43 pm - 1:53 pmTYS Knoxville McGhee Tyson-GSP Greenville

23h 10m1 stop Orlando Sanford Intl

9:41 am - 10:05 amGSP Greenville-TYS Knoxville McGhee Tyson

24h 24m1 stop Fort Lauderdale

$400Allegiant Air

Wed, Oct 28 - Fri, Oct 30

7:00 am - 8:38 amTYS Knoxville McGhee Tyson-CHS Charleston

25h 38m2 stops Key West Orlando

4:57 pm - 5:14 pmCHS Charleston-TYS Knoxville McGhee Tyson

24h 17m1 stop Fort Lauderdale

$409Multiple Airlines

Fri, Oct 23 - Mon, Oct 26

7:00 am - 8:38 amTYS Knoxville McGhee Tyson-CHS Charleston

25h 38m1 stop Orlando

10:13 pm - 8:38 pmCHS Charleston-TYS Knoxville McGhee Tyson

22h 25m1 stop Fort Lauderdale

$421Multiple Airlines

Mon, Oct 26 - Thu, Oct 29

7:00 am - 3:47 pmTYS Knoxville McGhee Tyson-GSP Greenville

8h 47m1 stop Orlando

2:42 pm - 5:14 pmGSP Greenville-TYS Knoxville McGhee Tyson

26h 32m1 stop Fort Lauderdale

$434Multiple Airlines

Mon, Oct 26 - Mon, Nov 2

2:38 pm - 8:10 pmTYS Knoxville McGhee Tyson-CAE Columbia Metropolitan

5h 32m1 stop Atlanta Hartsfield-Jackson

7:19 pm - 11:59 pmCAE Columbia Metropolitan-TYS Knoxville McGhee Tyson

4h 40m1 stop Atlanta Hartsfield-Jackson

$572Delta

Sat, Oct 24 - Sun, Oct 25

4:11 pm - 8:10 pmTYS Knoxville McGhee Tyson-CAE Columbia Metropolitan

3h 59m1 stop Atlanta Hartsfield-Jackson

7:19 pm - 11:59 pmCAE Columbia Metropolitan-TYS Knoxville McGhee Tyson

4h 40m1 stop Atlanta Hartsfield-Jackson

$617Delta

Sat, Oct 24 - Sun, Oct 25

3:41 pm - 8:05 pmTYS Knoxville McGhee Tyson-CAE Columbia Metropolitan

4h 24m1 stop Charlotte Douglas

11:03 am - 4:18 pmCAE Columbia Metropolitan-TYS Knoxville McGhee Tyson

5h 15m1 stop Charlotte Douglas

$627American Airlines

Fri, Oct 23 - Sun, Oct 25

5:40 am - 10:43 amTYS Knoxville McGhee Tyson-CAE Columbia Metropolitan

5h 03m1 stop Atlanta Hartsfield-Jackson

5:59 pm - 11:59 pmCAE Columbia Metropolitan-TYS Knoxville McGhee Tyson

6h 00m1 stop Atlanta Hartsfield-Jackson

$627Delta

Fri, Oct 23 - Sun, Oct 25

4:49 pm - 9:51 pmTYS Knoxville McGhee Tyson-CAE Columbia Metropolitan

5h 02m1 stop Charlotte Douglas

8:30 pm - 11:55 pmCAE Columbia Metropolitan-TYS Knoxville McGhee Tyson

3h 25m1 stop Charlotte Douglas

$651American Airlines

Fri, Oct 23 - Sun, Oct 25

10:00 am - 3:44 pmTYS Knoxville McGhee Tyson-CHS Charleston

5h 44m1 stop Charlotte Douglas

8:08 pm - 11:55 pmCHS Charleston-TYS Knoxville McGhee Tyson

3h 47m1 stop Charlotte Douglas

$667American Airlines

Fri, Oct 23 - Sun, Oct 25

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Delta flights from Knoxville to South Carolina

Our best Delta deals on Knoxville to South Carolina flight tickets

Delta

Jan 5

TYS6:00 amKnoxville McGhee Tyson

4h 08m

1 stop

MYR10:08 amMyrtle Beach Intl

Jan 9

MYR6:00 amMyrtle Beach Intl

5h 06m

1 stop

TYS11:06 amKnoxville McGhee Tyson

$239

Delta

Dec 1

TYS5:40 amKnoxville McGhee Tyson

4h 35m

1 stop

CHS10:15 amCharleston

Dec 8

CHS5:10 amCharleston

4h 51m

1 stop

TYS10:01 amKnoxville McGhee Tyson

$251

Delta

Mar 7

TYS2:25 pmKnoxville McGhee Tyson

3h 30m

1 stop

MYR5:55 pmMyrtle Beach Intl

Mar 13

MYR6:00 amMyrtle Beach Intl

3h 12m

1 stop

TYS9:12 amKnoxville McGhee Tyson

$367

United Airlines flights from Knoxville to South Carolina

Our best United Airlines deals on Knoxville to South Carolina flight tickets

United Airlines

Jan 6

TYS2:04 pmKnoxville McGhee Tyson

25h 09m

1 stop

CHS3:13 pmCharleston

Jan 9

CHS9:46 amCharleston

11h 19m

1 stop

TYS9:05 pmKnoxville McGhee Tyson

$599

United Airlines

Jan 6

TYS2:04 pmKnoxville McGhee Tyson

25h 09m

1 stop

CHS3:13 pmCharleston

Jan 9

CHS9:46 amCharleston

11h 19m

1 stop

TYS9:05 pmKnoxville McGhee Tyson

$602

United Airlines

Jan 6

TYS10:45 amKnoxville McGhee Tyson

27h 01m

1 stop

CHS1:46 pmCharleston

Jan 9

CHS9:46 amCharleston

11h 19m

1 stop

TYS9:05 pmKnoxville McGhee Tyson

$633

momondo Fare Finder

Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Wed 2/3

7:14 pm-10:28 pm

1 stop3h 14m

Myrtle Beach Intl

Sat 2/6

5:06 pm-8:46 pm

1 stop3h 40m

$239

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Tue 1/5

6:00 am-10:08 am

1 stop4h 08m

Myrtle Beach Intl

Sat 1/9

6:00 am-11:06 am

1 stop5h 06m

$239

KnoxvilleCharleston

TYS Knoxville McGhee Tyson - CHS Charleston

TYSCHS

Knoxville McGhee Tyson

Tue 12/1

5:40 am-10:15 am

1 stop4h 35m

Charleston

Tue 12/8

5:10 am-10:01 am

1 stop4h 51m

$251

KnoxvilleGreenville

TYS Knoxville McGhee Tyson - GSP Greenville

TYSGSP

Knoxville McGhee Tyson

Thu 11/5

9:28 pm-2:42 pm

1 stop17h 14m

Greenville

Mon 11/9

2:42 pm-5:18 pm

1 stop26h 36m

$252

KnoxvilleCharleston

TYS Knoxville McGhee Tyson - CHS Charleston

TYSCHS

Knoxville McGhee Tyson

Tue 12/1

7:55 am-12:45 pm

1 stop4h 50m

Charleston

Tue 12/8

8:00 am-7:50 pm

2 stops11h 50m

$256

KnoxvilleGreenville

TYS Knoxville McGhee Tyson - GSP Greenville

TYSGSP

Knoxville McGhee Tyson

Thu 11/5

9:28 pm-2:42 pm

1 stop17h 14m

Greenville

Mon 11/9

8:52 pm-5:18 pm

2 stops20h 26m

$275

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Sat 11/14

4:12 pm-9:05 pm

1 stop4h 53m

Myrtle Beach Intl

Wed 11/18

5:03 pm-8:43 pm

1 stop3h 40m

$329

KnoxvilleHilton Head Island

TYS Knoxville McGhee Tyson - HHH Hilton Head Island

TYSHHH

Knoxville McGhee Tyson

Wed 12/2

10:20 am-3:53 pm

1 stop5h 33m

Hilton Head Island

Wed 12/9

12:33 pm-4:43 pm

1 stop4h 10m

$351

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Sat 1/2

6:38 am-12:15 pm

1 stop5h 37m

Myrtle Beach Intl

Sat 1/9

1:50 pm-6:42 pm

1 stop4h 52m

$353

Quickest round-trip

KnoxvilleMyrtle Beach

TYS Knoxville McGhee Tyson - MYR Myrtle Beach Intl

TYSMYR

Knoxville McGhee Tyson

Sun 3/7

2:25 pm-5:55 pm

1 stop3h 30m

Myrtle Beach Intl

Thu 3/11

6:00 am-9:12 am

1 stop3h 12m

$367

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Knoxville is in September. Flight prices, which tend to average around $321, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Knoxville during August instead. Flights to South Carolina in August, while not as cheap as those in September, still average around $336.

Cheap Knoxville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South Carolina

Best Price Found	$120
Fastest flight time	1h 20m
Direct flights	None

The best one-way flight to South Carolina from Knoxville in the past 72 hours is $120. The best round-trip flight deal from Knoxville to South Carolina found on momondo in the last 72 hours is $239.

The fastest flight from Knoxville to South Carolina takes 1h 20m

There are no direct flights from Knoxville to South Carolina. There are no popular flight routes from Knoxville to South Carolina.

Search flight deals

Frequently asked questions about flying from Knoxville to South Carolina

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?
Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?
There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of October 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to South Carolina

Compare and see reviews for airlines that fly from Knoxville to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $236	Free Cancellation	Rating 7.8 8,661 reviews		Search Delta flights
American Airlines	PriceFrom $273	Free Cancellation	Rating 7.0 12,186 reviews		Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South Carolina?

It is quick and easy to find Knoxville to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Knoxville to South Carolina with flexible booking policies on momondo?

All flight searches from Knoxville to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to South Carolina.

I’m not ready to book a flight from Knoxville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.