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Cheap flights from Knoxville to South Carolina from $92

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to South Carolina departing on 1/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:29 am - 5:36 pm
TYS
-
CHS
8h 07m1 stop
Multiple Airlines Logo
3:01 pm - 5:28 pm
CHS
-
TYS
26h 27m1 stop
$212Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
9:29 am - 5:36 pm
TYS
-
CHS
8h 07m1 stop
Multiple Airlines Logo
3:01 pm - 5:28 pm
CHS
-
TYS
26h 27m1 stop
$220Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
American Airlines Logo
6:00 am - 8:35 am
TYS
-
CLT
26h 35m1 stop
American Airlines Logo
10:30 am - 11:47 am
CLT
-
TYS
1h 17mnonstop
$221American Airlines
Sat, Jan 17 - Sun, Jan 18
Allegiant Air Logo
9:29 am - 5:38 pm
TYS
-
CAE
8h 09m1 stop
Allegiant Air Logo
12:20 pm - 6:36 pm
CAE
-
TYS
6h 16m1 stop
$228Allegiant Air
Sun, Jan 11 - Thu, Jan 15
Allegiant Air Logo
7:40 am - 1:13 pm
TYS
-
CAE
5h 33m1 stop
Allegiant Air Logo
3:48 pm - 10:46 pm
CAE
-
TYS
6h 58m1 stop
$253Allegiant Air
Fri, Feb 13 - Sun, Feb 15
American Airlines Logo
5:17 pm - 11:16 pm
TYS
-
SAV
5h 59m1 stop
American Airlines Logo
5:00 am - 11:17 am
SAV
-
TYS
6h 17m1 stop
$265American Airlines
Tue, Feb 10 - Sat, Feb 14
Delta Logo
5:35 am - 9:45 am
TYS
-
MYR
4h 10m1 stop
Delta Logo
6:00 am - 9:16 am
MYR
-
TYS
3h 16m1 stop
$286Delta
Tue, Mar 3 - Sun, Mar 8
Delta Logo
5:35 am - 9:45 am
TYS
-
MYR
4h 10m1 stop
Delta Logo
6:00 am - 9:16 am
MYR
-
TYS
3h 16m1 stop
$296Delta
Mon, Mar 2 - Sun, Mar 8
Southwest Logo
7:25 pm - 10:40 am
TYS
-
MYR
15h 15m2 stops
Southwest Logo
3:40 pm - 9:10 pm
MYR
-
TYS
5h 30m1 stop
$297Southwest
Fri, Mar 6 - Wed, Mar 11
Southwest Logo
7:25 pm - 10:40 am
TYS
-
MYR
15h 15m2 stops
Southwest Logo
10:40 am - 9:10 pm
MYR
-
TYS
10h 30m2 stops
$302Southwest
Fri, Mar 6 - Wed, Mar 11

American Airlines flights from Knoxville to South Carolina

Our best American Airlines deals on Knoxville to South Carolina flight tickets
American Airlines
Jan 17
TYS6:00 amKnoxville McGhee Tyson
26h 35m
1 stop
CLT8:35 amCharlotte Douglas
Jan 18
CLT10:30 amCharlotte Douglas
1h 17m
TYS11:47 amKnoxville McGhee Tyson
$221
Find similar
American Airlines
Feb 10
TYS5:17 pmKnoxville McGhee Tyson
5h 59m
1 stop
SAV11:16 pmSavannah/Hilton Head
Feb 14
SAV5:00 amSavannah/Hilton Head
6h 17m
1 stop
TYS11:17 amKnoxville McGhee Tyson
$265
Find similar
American Airlines
Jan 17
TYS6:05 amKnoxville McGhee Tyson
3h 43m
1 stop
MYR9:48 amMyrtle Beach Intl
Jan 19
MYR6:23 amMyrtle Beach Intl
3h 22m
1 stop
TYS9:45 amKnoxville McGhee Tyson
$275
Find similar

United Airlines flights from Knoxville to South Carolina

Our best United Airlines deals on Knoxville to South Carolina flight tickets
United Airlines
Feb 2
TYS5:29 pmKnoxville McGhee Tyson
23h 55m
1 stop
CLT5:24 pmCharlotte Douglas
Feb 6
CLT7:44 pmCharlotte Douglas
19h 05m
1 stop
TYS2:49 pmKnoxville McGhee Tyson
$474
Find similar
United Airlines
Jan 21
TYS9:30 amKnoxville McGhee Tyson
9h 25m
1 stop
CAE6:55 pmColumbia Metropolitan
Jan 24
CAE2:49 pmColumbia Metropolitan
30h 03m
2 stops
TYS8:52 pmKnoxville McGhee Tyson
$494
Find similar
United Airlines
Jan 31
TYS7:20 pmKnoxville McGhee Tyson
24h 05m
1 stop
SAV7:25 pmSavannah/Hilton Head
Feb 6
SAV2:13 pmSavannah/Hilton Head
20h 44m
1 stop
TYS10:57 amKnoxville McGhee Tyson
$511
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 27, 2025.
Use the filters below to find and compare flights from Knoxville to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/22

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Thu 1/29

3:01 pm-5:28 pm

1 stop26h 27m

$212

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/22

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Thu 1/29

3:01 pm-5:28 pm

1 stop26h 27m

$220

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 1/17

6:00 am-8:35 am

1 stop26h 35m

Charlotte Douglas

Sun 1/18

10:30 am-11:47 am

Nonstop1h 17m

$221

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Sun 1/11

9:29 am-5:38 pm

1 stop8h 09m

Columbia Metropolitan

Thu 1/15

12:20 pm-6:36 pm

1 stop6h 16m

$228

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Fri 2/13

7:40 am-1:13 pm

1 stop5h 33m

Columbia Metropolitan

Sun 2/15

3:48 pm-10:46 pm

1 stop6h 58m

$253

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Tue 2/10

5:17 pm-11:16 pm

1 stop5h 59m

Savannah/Hilton Head

Sat 2/14

5:00 am-11:17 am

1 stop6h 17m

$265

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 3/3

5:35 am-9:45 am

1 stop4h 10m

Myrtle Beach Intl

Sun 3/8

6:00 am-9:16 am

1 stop3h 16m

$286

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 3/2

5:35 am-9:45 am

1 stop4h 10m

Myrtle Beach Intl

Sun 3/8

6:00 am-9:16 am

1 stop3h 16m

$296

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 3/6

7:25 pm-10:40 am

2 stops15h 15m

Myrtle Beach Intl

Wed 3/11

3:40 pm-9:10 pm

1 stop5h 30m

$297

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 3/6

7:25 pm-10:40 am

2 stops15h 15m

Myrtle Beach Intl

Wed 3/11

10:40 am-9:10 pm

2 stops10h 30m

$302

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Knoxville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Knoxville is in August. Flight prices, which tend to average around $320, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Knoxville during May instead. Flights to South Carolina in May, while not as cheap as those in August, still average around $366.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Saturday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $456. The most expensive day to fly to South Carolina is Monday, with ticket prices averaging around $678.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Knoxville to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $478. Try not to purchase tickets in the afternoon because they tend to be around $588. Of course, these prices can vary depending on the time of year and what airport you fly to.

Cheap Knoxville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South Carolina

Fastest flight time

1h 21m

Direct flights

Mon, Tue, Thu, Fri, Sat and Sun

Airports in South Carolina

57 airports
The fastest flight from Knoxville to South Carolina takes 1h 21m
Direct flights go from Knoxville to South Carolina on Monday, Tuesday, Thursday, Friday, Saturday and Sunday. There are no airlines offering direct flights.
There are 57 airports in South Carolina. From Knoxville there are direct flights to Charlotte Douglas (CLT).
Search flight deals

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?

    Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to South Carolina

Compare and see reviews for airlines that fly from Knoxville to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $198Free CancellationRating
7.2
11,067 reviews
Search American Airlines flights
DeltaPriceFrom $228Free CancellationRating
7.9
8,018 reviews
Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South Carolina?

It is quick and easy to find Knoxville to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Knoxville to South Carolina with flexible booking policies on momondo?

All flight searches from Knoxville to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to South Carolina.

I’m not ready to book a flight from Knoxville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.

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