How many flights depart from Knoxville to South Carolina on average per week?

As of March 2026, 12 flights take off from Knoxville and land in South Carolina each week. The most common flight departure day for this route is Sat, with 67% of weekly flights taking off on this day.

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?

Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?

There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of March 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$83 Cheap Flights from Knoxville to South Carolina in 2026

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Find the cheapest flights from Knoxville to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

7:40 am - 8:21 am

TYS

CLT

24h 41m

1 stop

9:00 pm - 10:40 am

CLT

TYS

13h 40m

1 stop

$210Multiple Airlines

Fri, Mar 20 - Tue, Mar 24

11:27 am - 9:36 pm

TYS

CLT

10h 09m

1 stop

4:48 pm - 3:33 pm

CLT

TYS

22h 45m

2 stops

$214Multiple Airlines

Thu, Apr 23 - Sat, Apr 25

7:50 am - 1:35 pm

TYS

SAV

5h 45m

1 stop

6:40 am - 12:00 pm

SAV

TYS

5h 20m

1 stop

$263Southwest

Tue, Mar 31 - Tue, Apr 7

6:35 am - 1:05 pm

TYS

MYR

6h 30m

1 stop

4:05 pm - 7:40 pm

MYR

TYS

3h 35m

1 stop

$271Southwest

Mon, May 4 - Wed, May 6

5:40 am - 9:16 am

TYS

SAV

3h 36m

1 stop

7:59 pm - 11:57 pm

SAV

TYS

3h 58m

1 stop

$279Delta

Thu, Apr 2 - Mon, Apr 6

2:05 pm - 2:45 pm

TYS

CAE

24h 40m

1 stop

3:35 pm - 2:39 pm

CAE

TYS

23h 04m

1 stop

$279Allegiant Air

Wed, Mar 18 - Sun, Mar 22

6:20 am - 2:45 pm

TYS

CAE

8h 25m

1 stop

3:35 pm - 2:39 pm

CAE

TYS

23h 04m

1 stop

$286Allegiant Air

Thu, Mar 19 - Sun, Mar 22

5:47 pm - 10:54 pm

TYS

SAV

5h 07m

1 stop

5:00 am - 8:42 am

SAV

TYS

3h 42m

1 stop

$291American Airlines

Tue, Mar 24 - Thu, Mar 26

5:30 am - 9:17 am

TYS

SAV

3h 47m

1 stop

10:20 am - 3:07 pm

SAV

TYS

4h 47m

1 stop

$317Delta

Thu, Sep 3 - Sun, Sep 6

8:00 am - 2:24 pm

TYS

HHH

6h 24m

1 stop

2:58 pm - 8:00 pm

HHH

TYS

5h 02m

1 stop

$337American Airlines

Sat, Apr 18 - Wed, Apr 22

United Airlines flights from Knoxville to South Carolina

Our best United Airlines deals on Knoxville to South Carolina flight tickets

United Airlines

Apr 9

TYS2:25 pmKnoxville McGhee Tyson

9h 32m

1 stop

CLT11:57 pmCharlotte Douglas

Apr 13

CLT7:40 pmCharlotte Douglas

15h 10m

1 stop

TYS10:50 amKnoxville McGhee Tyson

$481

United Airlines

Jul 1

TYS5:45 amKnoxville McGhee Tyson

8h 27m

1 stop

CLT2:12 pmCharlotte Douglas

Aug 31

CLT6:00 amCharlotte Douglas

17h 57m

1 stop

TYS11:57 pmKnoxville McGhee Tyson

$487

United Airlines

Aug 21

TYS7:19 pmKnoxville McGhee Tyson

18h 51m

1 stop

CAE2:10 pmColumbia Metropolitan

Aug 25

CAE10:18 amColumbia Metropolitan

10h 10m

1 stop

TYS8:28 pmKnoxville McGhee Tyson

$515

American Airlines flights from Knoxville to South Carolina

Our best American Airlines deals on Knoxville to South Carolina flight tickets

American Airlines

Mar 20

TYS6:05 amKnoxville McGhee Tyson

26h 20m

1 stop

CLT8:25 amCharlotte Douglas

Mar 21

CLT9:53 amCharlotte Douglas

1h 27m

TYS11:20 amKnoxville McGhee Tyson

$249

American Airlines

Mar 25

TYS5:00 amKnoxville McGhee Tyson

3h 32m

1 stop

MYR8:32 amMyrtle Beach Intl

Mar 31

MYR5:40 pmMyrtle Beach Intl

5h 08m

1 stop

TYS10:48 pmKnoxville McGhee Tyson

$283

American Airlines

Mar 24

TYS5:47 pmKnoxville McGhee Tyson

5h 07m

1 stop

SAV10:54 pmSavannah/Hilton Head

Mar 26

SAV5:00 amSavannah/Hilton Head

3h 42m

1 stop

TYS8:42 amKnoxville McGhee Tyson

$291

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 3/20

7:40 am-8:21 am

1 stop24h 41m

Charlotte Douglas

Tue 3/24

9:00 pm-10:40 am

1 stop13h 40m

$210

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 4/23

11:27 am-9:36 pm

1 stop10h 09m

Charlotte Douglas

Sat 4/25

4:48 pm-3:33 pm

2 stops22h 45m

$214

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Tue 3/31

7:50 am-1:35 pm

1 stop5h 45m

Savannah/Hilton Head

Tue 4/7

6:40 am-12:00 pm

1 stop5h 20m

$263

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 5/4

6:35 am-1:05 pm

1 stop6h 30m

Myrtle Beach Intl

Wed 5/6

4:05 pm-7:40 pm

1 stop3h 35m

$271

Quickest round-trip

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Thu 4/2

5:40 am-9:16 am

1 stop3h 36m

Savannah/Hilton Head

Mon 4/6

7:59 pm-11:57 pm

1 stop3h 58m

$279

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Wed 3/18

2:05 pm-2:45 pm

1 stop24h 40m

Columbia Metropolitan

Sun 3/22

3:35 pm-2:39 pm

1 stop23h 04m

$279

KnoxvilleColumbia

TYS - CAE

TYSCAE

Knoxville McGhee Tyson

Thu 3/19

6:20 am-2:45 pm

1 stop8h 25m

Columbia Metropolitan

Sun 3/22

3:35 pm-2:39 pm

1 stop23h 04m

$286

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Tue 3/24

5:47 pm-10:54 pm

1 stop5h 07m

Savannah/Hilton Head

Thu 3/26

5:00 am-8:42 am

1 stop3h 42m

$291

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Thu 9/3

5:30 am-9:17 am

1 stop3h 47m

Savannah/Hilton Head

Sun 9/6

10:20 am-3:07 pm

1 stop4h 47m

$317

KnoxvilleHilton Head Island

TYS - HHH

TYSHHH

Knoxville McGhee Tyson

Sat 4/18

8:00 am-2:24 pm

1 stop6h 24m

Hilton Head Island

Wed 4/22

2:58 pm-8:00 pm

1 stop5h 02m

$337

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Airlines

Other information

What is the cheapest airline that flies from Knoxville McGhee Tyson to South Carolina?

Southwest, Allegiant Air, and Delta are the most popular carriers operating from Knoxville McGhee Tyson to South Carolina

Cheap Knoxville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South Carolina

Fastest flight time	1h 27m
Direct flights	Mon, Tue, Wed, Fri, Sat and Sun
Airports in South Carolina	57 airports

The fastest flight from Knoxville to South Carolina takes 1h 27m

Direct flights go from Knoxville to South Carolina on Monday, Tuesday, Wednesday, Friday, Saturday and Sunday. There are no airlines offering direct flights.

There are 57 airports in South Carolina. From Knoxville there are direct flights to Charlotte Douglas (CLT).

Search flight deals

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?
Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?
There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of March 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to South Carolina

Compare and see reviews for airlines that fly from Knoxville to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $125	Free Cancellation	Rating 7.9 8,271 reviews		Search Delta flights
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.1 11,398 reviews		Search American Airlines flights

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I’m not ready to book a flight from Knoxville to South Carolina right now. Can momondo alert me if prices change?

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