How many flights depart from Knoxville to South Carolina on average per week?

As of June 2026, 63 flights take off from Knoxville and land in South Carolina each week. The most common flight departure day for this route is Mon, with 16% of weekly flights taking off on this day.

What is the cheapest airline that flies from Knoxville McGhee Tyson to South Carolina?

Southwest, Delta, and American Airlines are the most popular carriers operating from Knoxville McGhee Tyson to South Carolina

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?

Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.

How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?

There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of June 2026.

How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$99 Cheap Flights from Knoxville to South Carolina in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

12:56 pm - 9:13 pm

TYS

CLT

8h 17m

1 stop

6:41 pm - 8:36 am

CLT

TYS

13h 55m

1 stop

$194Multiple Airlines

Wed, Aug 5 - Thu, Aug 13

1:05 pm - 9:07 pm

TYS

CLT

8h 02m

1 stop

6:41 pm - 12:09 pm

CLT

TYS

17h 28m

1 stop

$210Multiple Airlines

Wed, Jul 15 - Wed, Jul 22

7:15 am - 1:55 pm

TYS

SAV

6h 40m

1 stop

1:52 pm - 4:42 pm

SAV

TYS

26h 50m

1 stop

$215Multiple Airlines

Thu, Jul 9 - Thu, Jul 16

5:00 pm - 5:55 pm

TYS

SAV

24h 55m

1 stop

7:16 pm - 4:42 pm

SAV

TYS

21h 26m

1 stop

$224Multiple Airlines

Tue, Jul 14 - Sun, Jul 19

6:05 pm - 11:00 pm

TYS

CHS

4h 55m

1 stop

7:48 pm - 10:58 pm

CHS

TYS

3h 10m

1 stop

$265American Airlines

Sat, Aug 8 - Mon, Aug 10

7:01 am - 6:23 am

TYS

CLT

23h 22m

1 stop

9:14 am - 10:31 am

CLT

TYS

1h 17mnonstop

$273American Airlines

Sat, Sep 12 - Sun, Sep 13

9:17 pm - 5:17 pm

TYS

SAV

20h 00m

2 stops

1:52 pm - 4:42 pm

SAV

TYS

26h 50m

1 stop

$284Allegiant Air

Thu, Jul 9 - Thu, Jul 16

5:45 pm - 9:50 pm

TYS

CLT

4h 05m

1 stop

6:35 am - 12:00 pm

CLT

TYS

5h 25m

1 stop

$287Southwest

Fri, Aug 14 - Mon, Aug 17

5:30 am - 9:42 am

TYS

CHS

4h 12m

1 stop

5:30 am - 11:06 am

CHS

TYS

5h 36m

1 stop

$301Delta

Mon, Oct 12 - Mon, Oct 19

6:00 am - 11:54 am

TYS

CHS

5h 54m

1 stop

5:30 am - 9:11 am

CHS

TYS

3h 41m

1 stop

$310Delta

Sun, Sep 6 - Sat, Sep 12

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Southwest flights from Knoxville to South Carolina

Our best Southwest deals on Knoxville to South Carolina flight tickets

Southwest

Aug 14

TYS5:45 pmKnoxville McGhee Tyson

4h 05m

1 stop

CLT9:50 pmCharlotte Douglas

Aug 17

CLT1:05 pmCharlotte Douglas

6h 50m

1 stop

TYS7:55 pmKnoxville McGhee Tyson

$287

Southwest

Aug 14

TYS7:10 amKnoxville McGhee Tyson

10h 25m

2 stops

CLT5:35 pmCharlotte Douglas

Aug 17

CLT6:35 amCharlotte Douglas

5h 25m

1 stop

TYS12:00 pmKnoxville McGhee Tyson

$298

Southwest

Aug 2

TYS7:00 pmKnoxville McGhee Tyson

4h 40m

1 stop

SAV11:40 pmSavannah/Hilton Head

Aug 6

SAV6:50 amSavannah/Hilton Head

5h 10m

1 stop

TYS12:00 pmKnoxville McGhee Tyson

$301

American Airlines flights from Knoxville to South Carolina

Our best American Airlines deals on Knoxville to South Carolina flight tickets

American Airlines

Aug 8

TYS6:05 pmKnoxville McGhee Tyson

4h 55m

1 stop

CHS11:00 pmCharleston

Aug 10

CHS7:48 pmCharleston

3h 10m

1 stop

TYS10:58 pmKnoxville McGhee Tyson

$265

American Airlines

Sep 12

TYS7:01 amKnoxville McGhee Tyson

23h 22m

1 stop

CLT6:23 amCharlotte Douglas

Sep 13

CLT9:14 amCharlotte Douglas

1h 17m

TYS10:31 amKnoxville McGhee Tyson

$273

American Airlines

Jul 14

TYS10:00 amKnoxville McGhee Tyson

4h 27m

1 stop

SAV2:27 pmSavannah/Hilton Head

Jul 21

SAV5:56 pmSavannah/Hilton Head

5h 55m

1 stop

TYS11:51 pmKnoxville McGhee Tyson

$295

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 8/5

12:56 pm-9:13 pm

1 stop8h 17m

Charlotte Douglas

Thu 8/13

6:41 pm-8:36 am

1 stop13h 55m

$194

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 7/15

1:05 pm-9:07 pm

1 stop8h 02m

Charlotte Douglas

Wed 7/22

6:41 pm-12:09 pm

1 stop17h 28m

$210

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Thu 7/9

7:15 am-1:55 pm

1 stop6h 40m

Savannah/Hilton Head

Thu 7/16

1:52 pm-4:42 pm

1 stop26h 50m

$215

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Tue 7/14

5:00 pm-5:55 pm

1 stop24h 55m

Savannah/Hilton Head

Sun 7/19

7:16 pm-4:42 pm

1 stop21h 26m

$224

Quickest round-trip

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 8/8

6:05 pm-11:00 pm

1 stop4h 55m

Charleston

Mon 8/10

7:48 pm-10:58 pm

1 stop3h 10m

$265

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 9/12

7:01 am-6:23 am

1 stop23h 22m

Charlotte Douglas

Sun 9/13

9:14 am-10:31 am

Nonstop1h 17m

$273

KnoxvilleSavannah

TYS - SAV

TYSSAV

Knoxville McGhee Tyson

Thu 7/9

9:17 pm-5:17 pm

2 stops20h 00m

Savannah/Hilton Head

Thu 7/16

1:52 pm-4:42 pm

1 stop26h 50m

$284

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 8/14

5:45 pm-9:50 pm

1 stop4h 05m

Charlotte Douglas

Mon 8/17

6:35 am-12:00 pm

1 stop5h 25m

$287

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 10/12

5:30 am-9:42 am

1 stop4h 12m

Charleston

Mon 10/19

5:30 am-11:06 am

1 stop5h 36m

$301

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sun 9/6

6:00 am-11:54 am

1 stop5h 54m

Charleston

Sat 9/12

5:30 am-9:11 am

1 stop3h 41m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Knoxville to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Knoxville is in September. Flight prices, which tend to average around $196, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Knoxville during October instead. Flights to South Carolina in October, while not as cheap as those in September, still average around $228.

Cheap Knoxville to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to South Carolina

Fastest flight time	1h 23m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Knoxville to South Carolina takes 1h 23m

Direct flights go from Knoxville to South Carolina every day.

There are 57 airports in South Carolina. From Knoxville there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Knoxville to South Carolina

When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to South Carolina?
Prices for flights from Knoxville McGhee Tyson Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to South Carolina?
There are 2 operators available for flights from Knoxville McGhee Tyson Airport to South Carolina as of June 2026.
How old do you have to be to fly from Knoxville McGhee Tyson Airport to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Knoxville to South Carolina

Compare and see reviews for airlines that fly from Knoxville to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.1 11,640 reviews		Search American Airlines flights
Delta	PriceFrom $238	Free Cancellation	Rating 7.9 8,394 reviews		Search Delta flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to South Carolina?

It is quick and easy to find Knoxville to South Carolina flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to South Carolina that suits you.

Can I find flights from Knoxville to South Carolina with flexible booking policies on momondo?

All flight searches from Knoxville to South Carolina on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to South Carolina.

I’m not ready to book a flight from Knoxville to South Carolina right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to South Carolina now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to South Carolina and let you know when they change.