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Cheap flights from Knoxville to Sioux Falls from $143

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sioux Falls departing on 6/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Sioux Falls

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:03 pm - 12:31 pm
TYS
-
FSD
15h 28m
1 stop
Allegiant Air Logo
6:51 pm - 9:13 pm
FSD
-
TYS
25h 22m
1 stop
$307Allegiant Air
Mon, Jun 1 - Thu, Jun 4
Delta Logo
6:30 am - 12:38 pm
TYS
-
FSD
7h 08m
1 stop
Delta Logo
10:58 am - 4:34 pm
FSD
-
TYS
4h 36m
1 stop
$319Delta
Fri, Aug 28 - Mon, Aug 31
Delta Logo
6:00 am - 12:38 pm
TYS
-
FSD
7h 38m
2 stops
Delta Logo
10:58 am - 4:34 pm
FSD
-
TYS
4h 36m
1 stop
$322Delta
Sat, Aug 29 - Mon, Aug 31
Delta Logo
6:30 am - 12:38 pm
TYS
-
FSD
7h 08m
1 stop
Delta Logo
5:15 am - 1:24 pm
FSD
-
TYS
7h 09m
2 stops
$324Delta
Fri, Aug 28 - Mon, Aug 31
Delta Logo
6:00 am - 12:38 pm
TYS
-
FSD
7h 38m
2 stops
Delta Logo
5:15 am - 3:07 pm
FSD
-
TYS
8h 52m
2 stops
$327Delta
Sat, Aug 29 - Mon, Aug 31
Delta Logo
5:45 am - 12:38 pm
TYS
-
FSD
7h 53m
2 stops
Delta Logo
5:04 am - 1:34 pm
FSD
-
TYS
7h 30m
2 stops
$329Delta
Fri, Aug 28 - Sun, Aug 30
Delta Logo
5:45 am - 12:38 pm
TYS
-
FSD
7h 53m
2 stops
Delta Logo
5:20 am - 11:11 am
FSD
-
TYS
4h 51m
1 stop
$334Delta
Fri, Aug 28 - Sun, Aug 30
Delta Logo
5:45 am - 12:38 pm
TYS
-
FSD
7h 53m
2 stops
Delta Logo
1:20 pm - 11:47 pm
FSD
-
TYS
9h 27m
2 stops
$340Delta
Fri, Aug 28 - Mon, Aug 31
Delta Logo
5:45 am - 12:38 pm
TYS
-
FSD
7h 53m
2 stops
Delta Logo
5:04 am - 1:34 pm
FSD
-
TYS
7h 30m
2 stops
$349Delta
Fri, Aug 28 - Sun, Aug 30
Delta Logo
7:55 am - 12:11 pm
TYS
-
FSD
5h 16m
1 stop
Delta Logo
1:00 pm - 11:46 pm
FSD
-
TYS
9h 46m
2 stops
$352Delta
Thu, Oct 15 - Tue, Oct 20

United Airlines flights from Knoxville to Sioux Falls

Our best United Airlines deals on Knoxville to Sioux Falls flight tickets
United Airlines
Aug 19
TYS5:57 pmKnoxville McGhee Tyson
4h 55m
1 stop
FSD9:52 pmSioux Falls Joe Foss Field
Aug 22
FSD3:08 pmSioux Falls Joe Foss Field
4h 40m
1 stop
TYS8:48 pmKnoxville McGhee Tyson
$385
United Airlines
Aug 19
TYS5:57 pmKnoxville McGhee Tyson
4h 55m
1 stop
FSD9:52 pmSioux Falls Joe Foss Field
Aug 22
FSD7:40 amSioux Falls Joe Foss Field
12h 50m
2 stops
TYS9:30 pmKnoxville McGhee Tyson
$390
United Airlines
Aug 19
TYS6:02 pmKnoxville McGhee Tyson
6h 35m
1 stop
FSD11:37 pmSioux Falls Joe Foss Field
Aug 22
FSD3:08 pmSioux Falls Joe Foss Field
4h 45m
1 stop
TYS8:53 pmKnoxville McGhee Tyson
$395

Allegiant Air flights from Knoxville to Sioux Falls

Our best Allegiant Air deals on Knoxville to Sioux Falls flight tickets
Allegiant Air
Jun 1
TYS10:03 pmKnoxville McGhee Tyson
15h 28m
1 stop
FSD12:31 pmSioux Falls Joe Foss Field
Jun 4
FSD6:51 pmSioux Falls Joe Foss Field
25h 22m
1 stop
TYS9:13 pmKnoxville McGhee Tyson
$307
Allegiant Air
Aug 2
TYS7:15 amKnoxville McGhee Tyson
26h 49m
2 stops
FSD9:04 amSioux Falls Joe Foss Field
Aug 5
FSD1:13 pmSioux Falls Joe Foss Field
22h 18m
1 stop
TYS12:31 pmKnoxville McGhee Tyson
$423
Allegiant Air
Jun 1
TYS7:30 amKnoxville McGhee Tyson
30h 01m
2 stops
FSD12:31 pmSioux Falls Joe Foss Field
Jun 4
FSD6:51 pmSioux Falls Joe Foss Field
19h 16m
1 stop
TYS3:07 pmKnoxville McGhee Tyson
$436

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mon 6/1

10:03 pm-12:31 pm

1 stop15h 28m

Sioux Falls Joe Foss Field

Thu 6/4

6:51 pm-9:13 pm

1 stop25h 22m

$307
Quickest round-trip

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

6:30 am-12:38 pm

1 stop7h 08m

Sioux Falls Joe Foss Field

Mon 8/31

10:58 am-4:34 pm

1 stop4h 36m

$319

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Sat 8/29

6:00 am-12:38 pm

2 stops7h 38m

Sioux Falls Joe Foss Field

Mon 8/31

10:58 am-4:34 pm

1 stop4h 36m

$322

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

6:30 am-12:38 pm

1 stop7h 08m

Sioux Falls Joe Foss Field

Mon 8/31

5:15 am-1:24 pm

2 stops7h 09m

$324

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Sat 8/29

6:00 am-12:38 pm

2 stops7h 38m

Sioux Falls Joe Foss Field

Mon 8/31

5:15 am-3:07 pm

2 stops8h 52m

$327

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

5:45 am-12:38 pm

2 stops7h 53m

Sioux Falls Joe Foss Field

Sun 8/30

5:04 am-1:34 pm

2 stops7h 30m

$329

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

5:45 am-12:38 pm

2 stops7h 53m

Sioux Falls Joe Foss Field

Sun 8/30

5:20 am-11:11 am

1 stop4h 51m

$334

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

5:45 am-12:38 pm

2 stops7h 53m

Sioux Falls Joe Foss Field

Mon 8/31

1:20 pm-11:47 pm

2 stops9h 27m

$340

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

5:45 am-12:38 pm

2 stops7h 53m

Sioux Falls Joe Foss Field

Sun 8/30

5:04 am-1:34 pm

2 stops7h 30m

$349

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 10/15

7:55 am-12:11 pm

1 stop5h 16m

Sioux Falls Joe Foss Field

Tue 10/20

1:00 pm-11:46 pm

2 stops9h 46m

$352

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Sioux Falls from

How to get the cheapest flight ticket from Knoxville to Sioux Falls

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Sioux Falls?

What is the cheapest month to fly to Sioux Falls?

The cheapest month to fly to Sioux Falls from Knoxville is in February. Flight prices, which tend to average around $269, are often lower during this time because this is during the off-season. If you’re not able to fly to Sioux Falls in February, then April is your next best option. Flight prices from Knoxville to Sioux Falls during April average around $278.

Can stopping save me money on Knoxville to Sioux Falls flights?

You could potentially save up to 31% on your flight if you consider stops on a Knoxville to Sioux Falls flight.

When to book flights from Knoxville to Sioux Falls

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sioux Falls according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sioux Falls (TYS to FSD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sioux Falls

Fastest flight time

5h 36m

Direct flights

None
The fastest flight from Knoxville to Sioux Falls takes 5h 36m
There are no direct flights from Knoxville to Sioux Falls. There are no popular flight routes from Knoxville to Sioux Falls.
Search flight deals

Frequently asked questions about flying from Knoxville to Sioux Falls

  • How far is Knoxville McGhee Tyson to Sioux Falls Joe Foss Field by plane?

    A flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field will travel around 856.6 mi. A reasonable flight in good conditions will take 5h 36m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport.

  • What documentation or ID do you need to fly to Sioux Falls Joe Foss Field Airport?

    The travel and health documents you'll need for your trip to Sioux Falls Joe Foss Field Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Sioux Falls Joe Foss Field Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Sioux Falls?

Best airlines flying from Knoxville to Sioux Falls

Compare and see reviews for airlines that fly from Knoxville to Sioux Falls with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,667 reviews
Search American Airlines flights
United AirlinesPriceFrom $269Free CancellationRating
7.4
9,694 reviews
Search United Airlines flights

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall
Worthington

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sioux Falls?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Sioux Falls from Knoxville.

Can I find flights from Knoxville to Sioux Falls with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Sioux Falls from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Sioux Falls?

Once all potential Knoxville to Sioux Falls flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Sioux Falls right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Sioux Falls now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Sioux Falls and let you know when they change.

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