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Cheap flights from Knoxville to Sioux Falls from $267

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sioux Falls departing on 7/26. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Sioux Falls

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
11:26 am - 5:03 pm
TYS
-
FSD
6h 37m
1 stop
American Airlines Logo
5:34 pm - 11:45 pm
FSD
-
TYS
5h 11m
1 stop
$326American Airlines
Sa, Jun 27 - Sa, Jul 4
American Airlines Logo
11:26 am - 5:03 pm
TYS
-
FSD
6h 37m
1 stop
American Airlines Logo
12:20 pm - 11:49 pm
FSD
-
TYS
10h 29m
2 stops
$331American Airlines
Sa, Jun 27 - Sa, Jul 4
Delta Logo
6:35 am - 10:21 am
TYS
-
FSD
4h 46m
1 stop
Delta Logo
5:00 am - 4:43 pm
FSD
-
TYS
10h 43m
2 stops
$342Delta
Di, Mrz 24 - Mo, Mrz 30
Delta Logo
5:40 am - 12:53 pm
TYS
-
FSD
8h 13m
2 stops
Delta Logo
5:00 am - 4:43 pm
FSD
-
TYS
10h 43m
2 stops
$347Delta
Mi, Mrz 25 - Mo, Mrz 30
Allegiant Air Logo
2:05 pm - 9:21 am
TYS
-
FSD
20h 16m
1 stop
Allegiant Air Logo
10:56 am - 11:32 pm
FSD
-
TYS
11h 36m
1 stop
$350Allegiant Air
Mi, Mrz 25 - Mo, Mrz 30
American Airlines Logo
6:00 am - 12:56 pm
TYS
-
FSD
7h 56m
1 stop
American Airlines Logo
6:00 am - 12:30 pm
FSD
-
TYS
5h 30m
1 stop
$351American Airlines
Do, Mai 7 - Sa, Mai 16
American Airlines Logo
4:29 pm - 9:40 pm
TYS
-
FSD
6h 11m
1 stop
American Airlines Logo
5:21 pm - 11:51 pm
FSD
-
TYS
5h 30m
1 stop
$352American Airlines
Mi, Mrz 25 - Sa, Mrz 28
American Airlines Logo
5:00 am - 12:41 pm
TYS
-
FSD
8h 41m
2 stops
American Airlines Logo
5:21 pm - 11:51 pm
FSD
-
TYS
5h 30m
1 stop
$357American Airlines
Mi, Mrz 25 - Sa, Mrz 28
American Airlines Logo
6:00 am - 12:56 pm
TYS
-
FSD
7h 56m
1 stop
American Airlines Logo
6:00 am - 12:30 pm
FSD
-
TYS
5h 30m
1 stop
$361American Airlines
Do, Mai 7 - Sa, Mai 16
American Airlines Logo
5:00 am - 1:36 pm
TYS
-
FSD
9h 36m
2 stops
American Airlines Logo
1:26 pm - 11:50 pm
FSD
-
TYS
9h 24m
2 stops
$362American Airlines
Mi, Mrz 25 - Sa, Mrz 28

American Airlines flights from Knoxville to Sioux Falls

Our best American Airlines deals on Knoxville to Sioux Falls flight tickets
American Airlines
Jun 27
TYS11:26 amKnoxville McGhee Tyson
6h 37m
1 stop
FSD5:03 pmSioux Falls Joe Foss Field
Jul 4
FSD5:34 pmSioux Falls Joe Foss Field
5h 11m
1 stop
TYS11:45 pmKnoxville McGhee Tyson
$326
American Airlines
Jun 27
TYS11:26 amKnoxville McGhee Tyson
6h 37m
1 stop
FSD5:03 pmSioux Falls Joe Foss Field
Jul 4
FSD12:20 pmSioux Falls Joe Foss Field
10h 29m
2 stops
TYS11:49 pmKnoxville McGhee Tyson
$331
American Airlines
May 7
TYS6:00 amKnoxville McGhee Tyson
7h 56m
1 stop
FSD12:56 pmSioux Falls Joe Foss Field
May 16
FSD6:00 amSioux Falls Joe Foss Field
5h 30m
1 stop
TYS12:30 pmKnoxville McGhee Tyson
$351

Delta flights from Knoxville to Sioux Falls

Our best Delta deals on Knoxville to Sioux Falls flight tickets
Delta
Mar 24
TYS6:35 amKnoxville McGhee Tyson
4h 46m
1 stop
FSD10:21 amSioux Falls Joe Foss Field
Mar 30
FSD5:00 amSioux Falls Joe Foss Field
10h 43m
2 stops
TYS4:43 pmKnoxville McGhee Tyson
$342
Delta
Mar 25
TYS5:40 amKnoxville McGhee Tyson
8h 13m
2 stops
FSD12:53 pmSioux Falls Joe Foss Field
Mar 30
FSD5:00 amSioux Falls Joe Foss Field
10h 43m
2 stops
TYS4:43 pmKnoxville McGhee Tyson
$347
Delta
Mar 25
TYS6:35 amKnoxville McGhee Tyson
7h 18m
1 stop
FSD12:53 pmSioux Falls Joe Foss Field
Mar 30
FSD5:00 amSioux Falls Joe Foss Field
10h 43m
2 stops
TYS4:43 pmKnoxville McGhee Tyson
$376

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated Februar 4, 2026.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Sa 6/27

11:26 am-5:03 pm

1 stop6h 37m

Sioux Falls Joe Foss Field

Sa 7/4

5:34 pm-11:45 pm

1 stop5h 11m

$326

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Sa 6/27

11:26 am-5:03 pm

1 stop6h 37m

Sioux Falls Joe Foss Field

Sa 7/4

12:20 pm-11:49 pm

2 stops10h 29m

$331

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Di 3/24

6:35 am-10:21 am

1 stop4h 46m

Sioux Falls Joe Foss Field

Mo 3/30

5:00 am-4:43 pm

2 stops10h 43m

$342

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mi 3/25

5:40 am-12:53 pm

2 stops8h 13m

Sioux Falls Joe Foss Field

Mo 3/30

5:00 am-4:43 pm

2 stops10h 43m

$347

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mi 3/25

2:05 pm-9:21 am

1 stop20h 16m

Sioux Falls Joe Foss Field

Mo 3/30

10:56 am-11:32 pm

1 stop11h 36m

$350

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Do 5/7

6:00 am-12:56 pm

1 stop7h 56m

Sioux Falls Joe Foss Field

Sa 5/16

6:00 am-12:30 pm

1 stop5h 30m

$351

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mi 3/25

4:29 pm-9:40 pm

1 stop6h 11m

Sioux Falls Joe Foss Field

Sa 3/28

5:21 pm-11:51 pm

1 stop5h 30m

$352

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mi 3/25

5:00 am-12:41 pm

2 stops8h 41m

Sioux Falls Joe Foss Field

Sa 3/28

5:21 pm-11:51 pm

1 stop5h 30m

$357

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Do 5/7

6:00 am-12:56 pm

1 stop7h 56m

Sioux Falls Joe Foss Field

Sa 5/16

6:00 am-12:30 pm

1 stop5h 30m

$361

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mi 3/25

5:00 am-1:36 pm

2 stops9h 36m

Sioux Falls Joe Foss Field

Sa 3/28

1:26 pm-11:50 pm

2 stops9h 24m

$362

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Sioux Falls

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Knoxville to Sioux Falls flights?

You could potentially save up to 56% on your flight if you consider stops on a Knoxville to Sioux Falls flight.

When to book flights from Knoxville to Sioux Falls

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sioux Falls according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sioux Falls (TYS to FSD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sioux Falls

Fastest flight time

4h 41m

Direct flights

None
The fastest flight from Knoxville to Sioux Falls takes 4h 41m
There are no direct flights from Knoxville to Sioux Falls. There are no popular flight routes from Knoxville to Sioux Falls.
Search flight deals

  • How far is Knoxville McGhee Tyson to Sioux Falls Joe Foss Field by plane?

    A flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field will travel around 856.6 mi. A reasonable flight in good conditions will take 4h 41m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport.

  • What documentation or ID do you need to fly to Sioux Falls Joe Foss Field Airport?

    The travel and health documents you'll need for your trip to Sioux Falls Joe Foss Field Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Sioux Falls Joe Foss Field Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Sioux Falls?

Best airlines flying from Knoxville to Sioux Falls

Compare and see reviews for airlines that fly from Knoxville to Sioux Falls with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,222 reviews
Search American Airlines flights
United AirlinesPriceFrom $269Free CancellationRating
7.4
9,236 reviews
Search United Airlines flights

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall
Worthington

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sioux Falls?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Sioux Falls from Knoxville.

Can I find flights from Knoxville to Sioux Falls with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Sioux Falls from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Sioux Falls?

Once all potential Knoxville to Sioux Falls flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Sioux Falls right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Sioux Falls now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Sioux Falls and let you know when they change.

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