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Cheap flights from Knoxville to Sioux Falls from $153

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sioux Falls departing on 11/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Sioux Falls

Cheap round-trip flights

American Airlines Logo
2:57 pm - 6:59 pmTYS-FSD
5h 02m1 stop
American Airlines Logo
6:45 am - 6:00 pmFSD-TYS
10h 15m2 stops
$324American Airlines
Find Deal
ter, dez 23 - ter, dez 30
American Airlines Logo
1:24 pm - 11:57 pmTYS-FSD
11h 33m2 stops
American Airlines Logo
6:45 am - 6:00 pmFSD-TYS
10h 15m2 stops
$329American Airlines
Find Deal
qui, dez 25 - ter, dez 30
American Airlines Logo
5:23 am - 12:28 pmTYS-FSD
8h 05m1 stop
American Airlines Logo
6:45 am - 6:00 pmFSD-TYS
10h 15m2 stops
$335American Airlines
Find Deal
qua, dez 24 - ter, dez 30
American Airlines Logo
8:30 am - 6:59 pmTYS-FSD
11h 29m2 stops
American Airlines Logo
6:45 am - 7:41 pmFSD-TYS
11h 56m2 stops
$340American Airlines
Find Deal
qua, dez 24 - ter, dez 30
Logo
7:00 am - 2:09 pmTYS-FSD
8h 09m1 stop
Logo
9:17 am - 9:54 amFSD-TYS
23h 37m1 stop
$347
Find Deal
dom, set 28 - qui, out 2
Allegiant Air Logo
9:56 pm - 6:02 pmTYS-FSD
21h 06m1 stop
Allegiant Air Logo
9:57 am - 10:51 pmFSD-TYS
11h 54m1 stop
$389Allegiant Air
Find Deal
dom, dez 21 - qua, dez 31
Allegiant Air Logo
12:50 pm - 6:02 pmTYS-FSD
6h 12m1 stop
Allegiant Air Logo
9:57 am - 10:51 pmFSD-TYS
11h 54m1 stop
$396Allegiant Air
Find Deal
seg, dez 22 - qua, dez 31
Logo
7:00 am - 2:09 pmTYS-FSD
8h 09m1 stop
Logo
11:41 am - 2:50 pmFSD-TYS
26h 09m2 stops
$468
Find Deal
dom, set 28 - qui, out 2
Delta Logo
6:15 am - 10:18 amTYS-FSD
5h 03m1 stop
Delta Logo
5:00 am - 9:07 pmFSD-TYS
15h 07m2 stops
$473Delta
Find Deal
dom, dez 21 - qua, dez 31
Delta Logo
6:04 pm - 10:57 pmTYS-FSD
5h 53m1 stop
Delta Logo
5:30 am - 10:45 amFSD-TYS
4h 15m1 stop
$479Delta
Find Deal
sex, out 17 - qua, out 22

American Airlines flights from Knoxville to Sioux Falls

Our best American Airlines deals on Knoxville to Sioux Falls flight tickets
American Airlines
Dec 23
TYS2:57 pmKnoxville McGhee Tyson
5h 02m
1 stop
FSD6:59 pmSioux Falls Joe Foss Field
Dec 30
FSD6:45 amSioux Falls Joe Foss Field
10h 15m
2 stops
TYS6:00 pmKnoxville McGhee Tyson
$324
Find similar
American Airlines
Dec 25
TYS1:24 pmKnoxville McGhee Tyson
11h 33m
2 stops
FSD11:57 pmSioux Falls Joe Foss Field
Dec 30
FSD6:45 amSioux Falls Joe Foss Field
10h 15m
2 stops
TYS6:00 pmKnoxville McGhee Tyson
$329
Find similar
American Airlines
Dec 24
TYS5:23 amKnoxville McGhee Tyson
8h 05m
1 stop
FSD12:28 pmSioux Falls Joe Foss Field
Dec 30
FSD6:45 amSioux Falls Joe Foss Field
10h 15m
2 stops
TYS6:00 pmKnoxville McGhee Tyson
$335
Find similar

Allegiant Air flights from Knoxville to Sioux Falls

Our best Allegiant Air deals on Knoxville to Sioux Falls flight tickets
Allegiant Air
Dec 21
TYS9:56 pmKnoxville McGhee Tyson
21h 06m
1 stop
FSD6:02 pmSioux Falls Joe Foss Field
Dec 31
FSD9:57 amSioux Falls Joe Foss Field
11h 54m
1 stop
TYS10:51 pmKnoxville McGhee Tyson
$389
Find similar
Allegiant Air
Dec 22
TYS12:50 pmKnoxville McGhee Tyson
6h 12m
1 stop
FSD6:02 pmSioux Falls Joe Foss Field
Dec 31
FSD9:57 amSioux Falls Joe Foss Field
11h 54m
1 stop
TYS10:51 pmKnoxville McGhee Tyson
$396
Find similar
Allegiant Air
Dec 22
TYS11:22 amKnoxville McGhee Tyson
7h 40m
1 stop
FSD6:02 pmSioux Falls Joe Foss Field
Jan 1
FSD3:21 pmSioux Falls Joe Foss Field
29h 27m
1 stop
TYS9:48 pmKnoxville McGhee Tyson
$470
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated setembro 15, 2025.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

ter 12/23

2:57 pm-6:59 pm

1 stop5h 02m

Sioux Falls Joe Foss Field

ter 12/30

6:45 am-6:00 pm

2 stops10h 15m

$324

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

qui 12/25

1:24 pm-11:57 pm

2 stops11h 33m

Sioux Falls Joe Foss Field

ter 12/30

6:45 am-6:00 pm

2 stops10h 15m

$329

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

qua 12/24

5:23 am-12:28 pm

1 stop8h 05m

Sioux Falls Joe Foss Field

ter 12/30

6:45 am-6:00 pm

2 stops10h 15m

$335

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

qua 12/24

8:30 am-6:59 pm

2 stops11h 29m

Sioux Falls Joe Foss Field

ter 12/30

6:45 am-7:41 pm

2 stops11h 56m

$340

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

dom 9/28

7:00 am-2:09 pm

1 stop8h 09m

Sioux Falls Joe Foss Field

qui 10/2

9:17 am-9:54 am

1 stop23h 37m

$347

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

dom 12/21

9:56 pm-6:02 pm

1 stop21h 06m

Sioux Falls Joe Foss Field

qua 12/31

9:57 am-10:51 pm

1 stop11h 54m

$389

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

seg 12/22

12:50 pm-6:02 pm

1 stop6h 12m

Sioux Falls Joe Foss Field

qua 12/31

9:57 am-10:51 pm

1 stop11h 54m

$396

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

dom 9/28

7:00 am-2:09 pm

1 stop8h 09m

Sioux Falls Joe Foss Field

qui 10/2

11:41 am-2:50 pm

2 stops26h 09m

$468

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

dom 12/21

6:15 am-10:18 am

1 stop5h 03m

Sioux Falls Joe Foss Field

qua 12/31

5:00 am-9:07 pm

2 stops15h 07m

$473

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

sex 10/17

6:04 pm-10:57 pm

1 stop5h 53m

Sioux Falls Joe Foss Field

qua 10/22

5:30 am-10:45 am

1 stop4h 15m

$479

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
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See travel insights to Sioux Falls from

How to get the cheapest flight ticket from Knoxville to Sioux Falls

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Sioux Falls?

The cheapest day to depart on your flight to Sioux Falls is on a Friday when prices can be found for as low as $289. This is often the case because there is less demand to fly during this day of the week. On the other hand, Thursday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $721.

What is the cheapest time of day to depart on your flight to Sioux Falls?

Our most recent data shows that the best time of day to fly to Sioux Falls is in the morning. Flights from Knoxville to Sioux Falls during this time can be as low as $443. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $577 on average. Flights to Sioux Falls from Knoxville at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Knoxville to Sioux Falls flights?

You could potentially save up to 54% on your flight if you consider stops on a Knoxville to Sioux Falls flight.

When to book flights from Knoxville to Sioux Falls

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sioux Falls according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sioux Falls (TYS to FSD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sioux Falls

Direct flights

None
There are no direct flights from Knoxville to Sioux Falls. There are no popular flight routes from Knoxville to Sioux Falls.
Search flight deals

  • How far is Knoxville McGhee Tyson to Sioux Falls Joe Foss Field by plane?

    A flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field will travel around 856.6 mi. A reasonable flight in good conditions will take 5h 02m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport.

  • What documentation or ID do you need to fly to Sioux Falls Joe Foss Field Airport?

    The travel and health documents you'll need for your trip to Sioux Falls Joe Foss Field Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Sioux Falls Joe Foss Field Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Sioux Falls?

Best airlines flying from Knoxville to Sioux Falls

Compare and see reviews for airlines that fly from Knoxville to Sioux Falls with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall
Worthington

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sioux Falls?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Sioux Falls from Knoxville.

Can I find flights from Knoxville to Sioux Falls with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Sioux Falls from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Sioux Falls?

Once all potential Knoxville to Sioux Falls flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Sioux Falls right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Sioux Falls now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Sioux Falls and let you know when they change.

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