Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Sioux Falls from $193

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sioux Falls departing on 6/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Sioux Falls

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
9:32 pm - 5:21 pm
TYS
-
FSD
20h 49m
1 stop
Allegiant Air Logo
11:35 am - 9:14 pm
FSD
-
TYS
8h 39m
1 stop
$287Allegiant Air
Thu, Apr 16 - Sun, Apr 19
American Airlines Logo
4:09 pm - 9:54 pm
TYS
-
FSD
6h 45m
1 stop
American Airlines Logo
3:17 pm - 9:21 pm
FSD
-
TYS
5h 04m
1 stop
$320American Airlines
Thu, May 7 - Sat, May 16
Allegiant Air Logo
7:30 am - 5:21 pm
TYS
-
FSD
10h 51m
1 stop
Allegiant Air Logo
9:35 am - 9:14 pm
FSD
-
TYS
10h 39m
1 stop
$324Allegiant Air
Fri, Apr 24 - Sun, Apr 26
Delta Logo
5:10 pm - 10:12 pm
TYS
-
FSD
6h 02m
1 stop
Delta Logo
4:17 pm - 10:59 pm
FSD
-
TYS
5h 42m
1 stop
$334Delta
Fri, Apr 3 - Tue, Apr 14
Delta Logo
5:10 pm - 10:12 pm
TYS
-
FSD
6h 02m
1 stop
Delta Logo
5:00 am - 4:42 pm
FSD
-
TYS
10h 42m
2 stops
$339Delta
Fri, Apr 3 - Tue, Apr 14
Allegiant Air Logo
8:30 am - 9:00 am
TYS
-
FSD
25h 30m
1 stop
Allegiant Air Logo
10:45 am - 9:48 pm
FSD
-
TYS
10h 03m
1 stop
$349Allegiant Air
Wed, Apr 1 - Mon, Apr 13
Allegiant Air Logo
10:03 pm - 12:31 pm
TYS
-
FSD
15h 28m
1 stop
Allegiant Air Logo
7:02 pm - 9:13 pm
FSD
-
TYS
25h 11m
1 stop
$354Allegiant Air
Mon, May 25 - Sun, May 31
Delta Logo
6:35 am - 10:21 am
TYS
-
FSD
4h 46m
1 stop
Delta Logo
4:17 pm - 10:59 pm
FSD
-
TYS
5h 42m
1 stop
$364Delta
Tue, Mar 31 - Tue, Apr 14
Allegiant Air Logo
8:30 am - 9:00 am
TYS
-
FSD
25h 30m
1 stop
Allegiant Air Logo
10:45 am - 9:48 pm
FSD
-
TYS
10h 03m
1 stop
$365Allegiant Air
Wed, Apr 1 - Fri, Apr 10
Delta Logo
5:40 am - 12:53 pm
TYS
-
FSD
8h 13m
2 stops
Delta Logo
4:25 pm - 10:43 pm
FSD
-
TYS
5h 18m
1 stop
$369Delta
Tue, Mar 31 - Sat, Apr 11

Delta flights from Knoxville to Sioux Falls

Our best Delta deals on Knoxville to Sioux Falls flight tickets
Delta
Apr 3
TYS5:10 pmKnoxville McGhee Tyson
6h 02m
1 stop
FSD10:12 pmSioux Falls Joe Foss Field
Apr 14
FSD4:17 pmSioux Falls Joe Foss Field
5h 42m
1 stop
TYS10:59 pmKnoxville McGhee Tyson
$334
Delta
Apr 3
TYS5:10 pmKnoxville McGhee Tyson
6h 02m
1 stop
FSD10:12 pmSioux Falls Joe Foss Field
Apr 14
FSD5:00 amSioux Falls Joe Foss Field
10h 42m
2 stops
TYS4:42 pmKnoxville McGhee Tyson
$339
Delta
Mar 31
TYS6:35 amKnoxville McGhee Tyson
4h 46m
1 stop
FSD10:21 amSioux Falls Joe Foss Field
Apr 11
FSD4:25 pmSioux Falls Joe Foss Field
5h 18m
1 stop
TYS10:43 pmKnoxville McGhee Tyson
$364

United Airlines flights from Knoxville to Sioux Falls

Our best United Airlines deals on Knoxville to Sioux Falls flight tickets
United Airlines
Apr 1
TYS4:30 pmKnoxville McGhee Tyson
8h 14m
1 stop
FSD11:44 pmSioux Falls Joe Foss Field
Apr 11
FSD3:10 pmSioux Falls Joe Foss Field
6h 24m
1 stop
TYS10:34 pmKnoxville McGhee Tyson
$364
United Airlines
Apr 4
TYS8:30 amKnoxville McGhee Tyson
8h 46m
1 stop
FSD4:16 pmSioux Falls Joe Foss Field
Apr 14
FSD1:43 pmSioux Falls Joe Foss Field
7h 46m
1 stop
TYS10:29 pmKnoxville McGhee Tyson
$414
United Airlines
Apr 4
TYS8:30 amKnoxville McGhee Tyson
8h 46m
1 stop
FSD4:16 pmSioux Falls Joe Foss Field
Apr 11
FSD7:39 amSioux Falls Joe Foss Field
11h 17m
2 stops
TYS7:56 pmKnoxville McGhee Tyson
$419

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 4/16

9:32 pm-5:21 pm

1 stop20h 49m

Sioux Falls Joe Foss Field

Sun 4/19

11:35 am-9:14 pm

1 stop8h 39m

$287

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 5/7

4:09 pm-9:54 pm

1 stop6h 45m

Sioux Falls Joe Foss Field

Sat 5/16

3:17 pm-9:21 pm

1 stop5h 04m

$320

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 4/24

7:30 am-5:21 pm

1 stop10h 51m

Sioux Falls Joe Foss Field

Sun 4/26

9:35 am-9:14 pm

1 stop10h 39m

$324

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 4/3

5:10 pm-10:12 pm

1 stop6h 02m

Sioux Falls Joe Foss Field

Tue 4/14

4:17 pm-10:59 pm

1 stop5h 42m

$334

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 4/3

5:10 pm-10:12 pm

1 stop6h 02m

Sioux Falls Joe Foss Field

Tue 4/14

5:00 am-4:42 pm

2 stops10h 42m

$339

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 4/1

8:30 am-9:00 am

1 stop25h 30m

Sioux Falls Joe Foss Field

Mon 4/13

10:45 am-9:48 pm

1 stop10h 03m

$349

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mon 5/25

10:03 pm-12:31 pm

1 stop15h 28m

Sioux Falls Joe Foss Field

Sun 5/31

7:02 pm-9:13 pm

1 stop25h 11m

$354
Quickest round-trip

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Tue 3/31

6:35 am-10:21 am

1 stop4h 46m

Sioux Falls Joe Foss Field

Tue 4/14

4:17 pm-10:59 pm

1 stop5h 42m

$364

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 4/1

8:30 am-9:00 am

1 stop25h 30m

Sioux Falls Joe Foss Field

Fri 4/10

10:45 am-9:48 pm

1 stop10h 03m

$365

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Tue 3/31

5:40 am-12:53 pm

2 stops8h 13m

Sioux Falls Joe Foss Field

Sat 4/11

4:25 pm-10:43 pm

1 stop5h 18m

$369

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 16 resultsSorted by cheapest first
1
2

See travel insights to Sioux Falls from

How to get the cheapest flight ticket from Knoxville to Sioux Falls

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Sioux Falls?

What is the cheapest month to fly to Sioux Falls?

The cheapest month to fly to Sioux Falls from Knoxville is in February. Flight prices, which tend to average around $269, are often lower during this time because this is during the off-season. If you’re not able to fly to Sioux Falls in February, then April is your next best option. Flight prices from Knoxville to Sioux Falls during April average around $278.

Can stopping save me money on Knoxville to Sioux Falls flights?

You could potentially save up to 31% on your flight if you consider stops on a Knoxville to Sioux Falls flight.

When to book flights from Knoxville to Sioux Falls

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sioux Falls according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sioux Falls (TYS to FSD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sioux Falls

Fastest flight time

4h 42m

Direct flights

None
The fastest flight from Knoxville to Sioux Falls takes 4h 42m
There are no direct flights from Knoxville to Sioux Falls. There are no popular flight routes from Knoxville to Sioux Falls.
Search flight deals

  • How far is Knoxville McGhee Tyson to Sioux Falls Joe Foss Field by plane?

    A flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field will travel around 856.6 mi. A reasonable flight in good conditions will take 4h 42m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport.

  • What documentation or ID do you need to fly to Sioux Falls Joe Foss Field Airport?

    The travel and health documents you'll need for your trip to Sioux Falls Joe Foss Field Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Sioux Falls Joe Foss Field Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Sioux Falls?

Best airlines flying from Knoxville to Sioux Falls

Compare and see reviews for airlines that fly from Knoxville to Sioux Falls with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,489 reviews
Search American Airlines flights
United AirlinesPriceFrom $269Free CancellationRating
7.4
9,455 reviews
Search United Airlines flights

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall
Worthington

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sioux Falls?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Sioux Falls from Knoxville.

Can I find flights from Knoxville to Sioux Falls with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Sioux Falls from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Sioux Falls?

Once all potential Knoxville to Sioux Falls flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Sioux Falls right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Sioux Falls now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Sioux Falls and let you know when they change.

An easier way to manage your Sioux Falls trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Tue 4/21
Tue 4/28
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States