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Cheap flights from Knoxville to Sioux Falls from $309

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sioux Falls departing on 8/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Knoxville to Sioux Falls

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
4:38 pm - 7:59 pm
TYS
-
FSD
4h 21m
1 stop
Delta Logo
5:30 am - 11:11 am
FSD
-
TYS
4h 41m
1 stop
$309Delta
Fri, Aug 28 - Sun, Aug 30
American Airlines Logo
6:05 pm - 12:30 am
TYS
-
FSD
7h 25m
2 stops
American Airlines Logo
6:24 am - 12:51 pm
FSD
-
TYS
5h 27m
1 stop
$314American Airlines
Fri, Aug 28 - Sun, Aug 30
American Airlines Logo
6:05 pm - 12:30 am
TYS
-
FSD
7h 25m
2 stops
American Airlines Logo
12:57 pm - 7:35 pm
FSD
-
TYS
5h 38m
1 stop
$329American Airlines
Fri, Aug 28 - Sun, Aug 30
American Airlines Logo
5:31 pm - 9:58 pm
TYS
-
FSD
5h 27m
1 stop
American Airlines Logo
5:34 pm - 11:51 pm
FSD
-
TYS
5h 17m
1 stop
$384American Airlines
Fri, Jul 24 - Fri, Jul 31
United Airlines Logo
6:02 pm - 11:22 pm
TYS
-
FSD
6h 20m
1 stop
United Airlines Logo
3:08 pm - 8:53 pm
FSD
-
TYS
4h 45m
1 stop
$385United Airlines
Wed, Aug 26 - Sat, Aug 29
American Airlines Logo
6:05 pm - 12:30 am
TYS
-
FSD
7h 25m
2 stops
American Airlines Logo
12:57 pm - 7:35 pm
FSD
-
TYS
5h 38m
1 stop
$389American Airlines
Fri, Aug 28 - Sun, Aug 30
United Airlines Logo
6:02 pm - 11:22 pm
TYS
-
FSD
6h 20m
1 stop
United Airlines Logo
6:00 am - 4:58 pm
FSD
-
TYS
9h 58m
2 stops
$390United Airlines
Wed, Aug 26 - Sat, Aug 29
American Airlines Logo
6:05 pm - 12:30 am
TYS
-
FSD
7h 25m
2 stops
American Airlines Logo
12:57 pm - 11:59 pm
FSD
-
TYS
10h 02m
2 stops
$433American Airlines
Fri, Aug 28 - Sun, Aug 30
United Airlines Logo
2:21 pm - 11:22 pm
TYS
-
FSD
10h 01m
2 stops
United Airlines Logo
6:00 am - 4:58 pm
FSD
-
TYS
9h 58m
2 stops
$435United Airlines
Wed, Aug 26 - Sat, Aug 29
American Airlines Logo
6:05 pm - 12:30 am
TYS
-
FSD
7h 25m
2 stops
American Airlines Logo
12:57 pm - 11:59 pm
FSD
-
TYS
10h 02m
2 stops
$449American Airlines
Fri, Aug 28 - Sun, Aug 30

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United Airlines flights from Knoxville to Sioux Falls

Our best United Airlines deals on Knoxville to Sioux Falls flight tickets
United Airlines
Aug 26
TYS6:02 pmKnoxville McGhee Tyson
6h 20m
1 stop
FSD11:22 pmSioux Falls Joe Foss Field
Aug 29
FSD3:08 pmSioux Falls Joe Foss Field
4h 45m
1 stop
TYS8:53 pmKnoxville McGhee Tyson
$385
United Airlines
Aug 26
TYS6:02 pmKnoxville McGhee Tyson
6h 20m
1 stop
FSD11:22 pmSioux Falls Joe Foss Field
Aug 29
FSD6:00 amSioux Falls Joe Foss Field
9h 58m
2 stops
TYS4:58 pmKnoxville McGhee Tyson
$390
United Airlines
Oct 27
TYS5:01 pmKnoxville McGhee Tyson
7h 42m
1 stop
FSD11:43 pmSioux Falls Joe Foss Field
Oct 31
FSD9:35 amSioux Falls Joe Foss Field
10h 09m
2 stops
TYS8:44 pmKnoxville McGhee Tyson
$430

Delta flights from Knoxville to Sioux Falls

Our best Delta deals on Knoxville to Sioux Falls flight tickets
Delta
Aug 28
TYS4:38 pmKnoxville McGhee Tyson
4h 21m
1 stop
FSD7:59 pmSioux Falls Joe Foss Field
Aug 30
FSD5:30 amSioux Falls Joe Foss Field
4h 41m
1 stop
TYS11:11 amKnoxville McGhee Tyson
$309
Delta
Jun 27
TYS10:24 amKnoxville McGhee Tyson
10h 14m
2 stops
FSD7:38 pmSioux Falls Joe Foss Field
Jul 1
FSD5:12 amSioux Falls Joe Foss Field
8h 37m
2 stops
TYS2:49 pmKnoxville McGhee Tyson
$753
Delta
Jun 27
TYS3:59 pmKnoxville McGhee Tyson
7h 55m
2 stops
FSD10:54 pmSioux Falls Joe Foss Field
Jul 1
FSD5:12 amSioux Falls Joe Foss Field
8h 37m
2 stops
TYS2:49 pmKnoxville McGhee Tyson
$757

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 25, 2026.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

4:38 pm-7:59 pm

1 stop4h 21m

Sioux Falls Joe Foss Field

Sun 8/30

5:30 am-11:11 am

1 stop4h 41m

$309

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

6:05 pm-12:30 am

2 stops7h 25m

Sioux Falls Joe Foss Field

Sun 8/30

6:24 am-12:51 pm

1 stop5h 27m

$314

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

6:05 pm-12:30 am

2 stops7h 25m

Sioux Falls Joe Foss Field

Sun 8/30

12:57 pm-7:35 pm

1 stop5h 38m

$329

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 7/24

5:31 pm-9:58 pm

1 stop5h 27m

Sioux Falls Joe Foss Field

Fri 7/31

5:34 pm-11:51 pm

1 stop5h 17m

$384

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 8/26

6:02 pm-11:22 pm

1 stop6h 20m

Sioux Falls Joe Foss Field

Sat 8/29

3:08 pm-8:53 pm

1 stop4h 45m

$385

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

6:05 pm-12:30 am

2 stops7h 25m

Sioux Falls Joe Foss Field

Sun 8/30

12:57 pm-7:35 pm

1 stop5h 38m

$389

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 8/26

6:02 pm-11:22 pm

1 stop6h 20m

Sioux Falls Joe Foss Field

Sat 8/29

6:00 am-4:58 pm

2 stops9h 58m

$390

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

6:05 pm-12:30 am

2 stops7h 25m

Sioux Falls Joe Foss Field

Sun 8/30

12:57 pm-11:59 pm

2 stops10h 02m

$433

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 8/26

2:21 pm-11:22 pm

2 stops10h 01m

Sioux Falls Joe Foss Field

Sat 8/29

6:00 am-4:58 pm

2 stops9h 58m

$435

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Fri 8/28

6:05 pm-12:30 am

2 stops7h 25m

Sioux Falls Joe Foss Field

Sun 8/30

12:57 pm-11:59 pm

2 stops10h 02m

$449

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Sioux Falls from

How to get the cheapest flight ticket from Knoxville to Sioux Falls

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Sioux Falls?

The cheapest month to fly to Sioux Falls from Knoxville is in February. Flight prices, which tend to average around $269, are often lower during this time because this is during the off-season. If you’re not able to fly to Sioux Falls in February, then April is your next best option. Flight prices from Knoxville to Sioux Falls during April average around $288.

Can stopping save me money on Knoxville to Sioux Falls flights?

You could potentially save up to 31% on your flight if you consider stops on a Knoxville to Sioux Falls flight.

When to book flights from Knoxville to Sioux Falls

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sioux Falls according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sioux Falls (TYS to FSD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sioux Falls

Fastest flight time

4h 50m

Direct flights

None
The fastest flight from Knoxville to Sioux Falls takes 4h 50m
There are no direct flights from Knoxville to Sioux Falls. There are no popular flight routes from Knoxville to Sioux Falls.
Search flight deals

Frequently asked questions about flying from Knoxville to Sioux Falls

  • How far is Knoxville McGhee Tyson to Sioux Falls Joe Foss Field by plane?

    A flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field will travel around 856.6 mi. A reasonable flight in good conditions will take 4h 50m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport.

  • What documentation or ID do you need to fly to Sioux Falls Joe Foss Field Airport?

    The travel and health documents you'll need for your trip to Sioux Falls Joe Foss Field Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Sioux Falls Joe Foss Field Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Sioux Falls?

Best airlines flying from Knoxville to Sioux Falls

Compare and see reviews for airlines that fly from Knoxville to Sioux Falls with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,756 reviews
Search American Airlines flights
United AirlinesPriceFrom $269Free CancellationRating
7.4
9,887 reviews
Search United Airlines flights
DeltaPriceFrom $339Free CancellationRating
7.8
8,440 reviews
Search Delta flights

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall
Worthington

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sioux Falls?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Sioux Falls from Knoxville.

Can I find flights from Knoxville to Sioux Falls with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Sioux Falls from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Sioux Falls?

Once all potential Knoxville to Sioux Falls flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Sioux Falls right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Sioux Falls now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Sioux Falls and let you know when they change.

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