Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Sioux Falls from $239

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Sioux Falls departing on 12/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Sioux Falls

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:06 am - 3:09 pmTYS-FSD
8h 03m1 stop
American Airlines Logo
10:43 am - 5:58 pmFSD-TYS
6h 15m1 stop
$249American Airlines
Find Deal
Wed, Dec 3 - Tue, Dec 9
American Airlines Logo
8:06 am - 3:09 pmTYS-FSD
8h 03m1 stop
American Airlines Logo
10:43 am - 10:55 pmFSD-TYS
11h 12m2 stops
$254American Airlines
Find Deal
Wed, Dec 3 - Tue, Dec 9
Delta Logo
5:40 am - 12:48 pmTYS-FSD
8h 08m2 stops
Delta Logo
5:14 am - 2:52 pmFSD-TYS
8h 38m2 stops
$259Delta
Find Deal
Thu, Dec 4 - Tue, Dec 9
Delta Logo
6:45 am - 12:28 pmTYS-FSD
6h 43m1 stop
Delta Logo
5:25 am - 1:25 pmFSD-TYS
7h 00m1 stop
$260Delta
Find Deal
Wed, Apr 15 - Sat, Apr 18
Delta Logo
6:45 am - 12:28 pmTYS-FSD
6h 43m1 stop
Delta Logo
1:20 pm - 11:46 pmFSD-TYS
9h 26m2 stops
$265Delta
Find Deal
Wed, Apr 15 - Sat, Apr 18
Allegiant Air Logo
6:23 pm - 9:07 amTYS-FSD
15h 44m1 stop
Allegiant Air Logo
7:01 pm - 11:38 pmFSD-TYS
27h 37m1 stop
$304Allegiant Air
Find Deal
Tue, Dec 23 - Fri, Jan 2
Allegiant Air Logo
4:20 pm - 9:11 amTYS-FSD
17h 51m1 stop
Allegiant Air Logo
9:57 am - 10:51 pmFSD-TYS
11h 54m1 stop
$318Allegiant Air
Find Deal
Thu, Dec 18 - Wed, Dec 24
Multiple Airlines Logo
5:44 pm - 9:11 amTYS-FSD
40h 27m2 stops
Multiple Airlines Logo
7:01 pm - 11:38 pmFSD-TYS
27h 37m1 stop
$332Multiple Airlines
Find Deal
Wed, Dec 24 - Fri, Jan 2
Multiple Airlines Logo
12:50 pm - 6:02 pmTYS-FSD
6h 12m1 stop
Multiple Airlines Logo
8:50 pm - 3:51 pmFSD-TYS
18h 01m1 stop
$341Multiple Airlines
Find Deal
Mon, Dec 22 - Mon, Dec 29
United Airlines Logo
6:45 am - 10:42 amTYS-FSD
4h 57m1 stop
United Airlines Logo
3:15 pm - 8:33 pmFSD-TYS
4h 18m1 stop
$397United Airlines
Find Deal
Tue, Nov 18 - Sat, Nov 22

United Airlines flights from Knoxville to Sioux Falls

Our best United Airlines deals on Knoxville to Sioux Falls flight tickets
United Airlines
Nov 13
TYS1:52 pmKnoxville McGhee Tyson
4h 45m
1 stop
FSD5:37 pmSioux Falls Joe Foss Field
Nov 15
FSD8:00 amSioux Falls Joe Foss Field
4h 17m
1 stop
TYS1:17 pmKnoxville McGhee Tyson
$339
Find similar
United Airlines
Nov 13
TYS8:26 amKnoxville McGhee Tyson
8h 52m
2 stops
FSD4:18 pmSioux Falls Joe Foss Field
Nov 15
FSD8:00 amSioux Falls Joe Foss Field
9h 04m
2 stops
TYS6:04 pmKnoxville McGhee Tyson
$349
Find similar
United Airlines
Nov 18
TYS6:45 amKnoxville McGhee Tyson
4h 57m
1 stop
FSD10:42 amSioux Falls Joe Foss Field
Nov 22
FSD3:15 pmSioux Falls Joe Foss Field
4h 18m
1 stop
TYS8:33 pmKnoxville McGhee Tyson
$397
Find similar

Delta flights from Knoxville to Sioux Falls

Our best Delta deals on Knoxville to Sioux Falls flight tickets
Delta
Dec 4
TYS5:40 amKnoxville McGhee Tyson
8h 08m
2 stops
FSD12:48 pmSioux Falls Joe Foss Field
Dec 9
FSD5:14 amSioux Falls Joe Foss Field
8h 38m
2 stops
TYS2:52 pmKnoxville McGhee Tyson
$259
Find similar
Delta
Apr 15
TYS6:45 amKnoxville McGhee Tyson
6h 43m
1 stop
FSD12:28 pmSioux Falls Joe Foss Field
Apr 18
FSD5:25 amSioux Falls Joe Foss Field
7h 00m
1 stop
TYS1:25 pmKnoxville McGhee Tyson
$260
Find similar
Delta
Apr 15
TYS6:45 amKnoxville McGhee Tyson
6h 43m
1 stop
FSD12:28 pmSioux Falls Joe Foss Field
Apr 18
FSD1:20 pmSioux Falls Joe Foss Field
9h 26m
2 stops
TYS11:46 pmKnoxville McGhee Tyson
$265
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Sioux Falls that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 3, 2025.
Use the filters below to find and compare flights from Knoxville to Sioux Falls that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 12/3

8:06 am-3:09 pm

1 stop8h 03m

Sioux Falls Joe Foss Field

Tue 12/9

10:43 am-5:58 pm

1 stop6h 15m

$249

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 12/3

8:06 am-3:09 pm

1 stop8h 03m

Sioux Falls Joe Foss Field

Tue 12/9

10:43 am-10:55 pm

2 stops11h 12m

$254

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 12/4

5:40 am-12:48 pm

2 stops8h 08m

Sioux Falls Joe Foss Field

Tue 12/9

5:14 am-2:52 pm

2 stops8h 38m

$259

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 4/15

6:45 am-12:28 pm

1 stop6h 43m

Sioux Falls Joe Foss Field

Sat 4/18

5:25 am-1:25 pm

1 stop7h 00m

$260

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 4/15

6:45 am-12:28 pm

1 stop6h 43m

Sioux Falls Joe Foss Field

Sat 4/18

1:20 pm-11:46 pm

2 stops9h 26m

$265

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Tue 12/23

6:23 pm-9:07 am

1 stop15h 44m

Sioux Falls Joe Foss Field

Fri 1/2

7:01 pm-11:38 pm

1 stop27h 37m

$304

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Thu 12/18

4:20 pm-9:11 am

1 stop17h 51m

Sioux Falls Joe Foss Field

Wed 12/24

9:57 am-10:51 pm

1 stop11h 54m

$318

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Wed 12/24

5:44 pm-9:11 am

2 stops40h 27m

Sioux Falls Joe Foss Field

Fri 1/2

7:01 pm-11:38 pm

1 stop27h 37m

$332

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Mon 12/22

12:50 pm-6:02 pm

1 stop6h 12m

Sioux Falls Joe Foss Field

Mon 12/29

8:50 pm-3:51 pm

1 stop18h 01m

$341

KnoxvilleSioux Falls

TYS - FSD

TYSFSD

Knoxville McGhee Tyson

Tue 11/18

6:45 am-10:42 am

1 stop4h 57m

Sioux Falls Joe Foss Field

Sat 11/22

3:15 pm-8:33 pm

1 stop4h 18m

$397

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

See travel insights to Sioux Falls from

How to get the cheapest flight ticket from Knoxville to Sioux Falls

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Sioux Falls?

What is the cheapest day to depart on your flight to Sioux Falls?

The cheapest day to depart on your flight to Sioux Falls is on a Friday when prices can be found for as low as $289. This is often the case because there is less demand to fly during this day of the week. On the other hand, Thursday is the most expensive day to depart from Knoxville because it is more convenient for both business and leisure travelers. As a result, prices tend to be around $721.

What is the cheapest time of day to depart on your flight to Sioux Falls?

Our most recent data shows that the best time of day to fly to Sioux Falls is in the morning. Flights from Knoxville to Sioux Falls during this time can be as low as $443. If you have a flexible travel schedule, then try to avoid flying at noon when prices are $577 on average. Flights to Sioux Falls from Knoxville at noon are generally more expensive because this time of day is more convenient for travelers’ schedules.

Can stopping save me money on Knoxville to Sioux Falls flights?

You could potentially save up to 36% on your flight if you consider stops on a Knoxville to Sioux Falls flight.

When to book flights from Knoxville to Sioux Falls

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Sioux Falls according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Sioux Falls (TYS to FSD) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Sioux Falls

Direct flights

None
There are no direct flights from Knoxville to Sioux Falls. There are no popular flight routes from Knoxville to Sioux Falls.
Search flight deals

  • How far is Knoxville McGhee Tyson to Sioux Falls Joe Foss Field by plane?

    A flight from Knoxville McGhee Tyson to Sioux Falls Joe Foss Field will travel around 856.6 mi. A reasonable flight in good conditions will take 4h 46m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Sioux Falls Joe Foss Field Airport.

  • What documentation or ID do you need to fly to Sioux Falls Joe Foss Field Airport?

    The travel and health documents you'll need for your trip to Sioux Falls Joe Foss Field Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Sioux Falls Joe Foss Field Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Sioux Falls?

Best airlines flying from Knoxville to Sioux Falls

Compare and see reviews for airlines that fly from Knoxville to Sioux Falls with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,038 reviews
Search American Airlines flights

Traveling to a place near Sioux Falls?

Book flights to Sioux Falls if you plan to visit one of these locations
Yankton
Marshall
Worthington

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Sioux Falls?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to Sioux Falls from Knoxville.

Can I find flights from Knoxville to Sioux Falls with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Sioux Falls from Knoxville with this policy.

How can momondo help me find flights from Knoxville to Sioux Falls?

Once all potential Knoxville to Sioux Falls flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Sioux Falls right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to Sioux Falls now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Sioux Falls and let you know when they change.

An easier way to manage your Sioux Falls trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 12/3
Wed 12/10
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States