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Cheap flights from Knoxville to Santa Fe from $264

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Santa Fe departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Santa Fe (TYS-SAF)

Cheap round-trip flights

American Airlines Logo
5:43 am - 9:21 amTYS-SAF
5h 38m1 stop
American Airlines Logo
10:43 am - 5:25 pmSAF-TYS
4h 42m1 stop
$264American Airlines
Find Deal
Thu, Jan 15 - Thu, Jan 22
American Airlines Logo
5:43 am - 9:21 amTYS-SAF
5h 38m1 stop
American Airlines Logo
8:11 am - 7:18 pmSAF-TYS
9h 07m2 stops
$274American Airlines
Find Deal
Thu, Jan 15 - Thu, Jan 22
American Airlines Logo
3:00 pm - 8:00 pmTYS-SAF
7h 00m1 stop
American Airlines Logo
6:03 am - 3:23 pmSAF-TYS
7h 20m1 stop
$344American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
5:51 am - 9:26 amTYS-SAF
5h 35m1 stop
American Airlines Logo
10:52 am - 9:39 pmSAF-TYS
8h 47m2 stops
$354American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
American Airlines Logo
4:27 pm - 8:21 pmTYS-SAF
5h 54m1 stop
American Airlines Logo
6:15 am - 3:37 pmSAF-TYS
7h 22m1 stop
$401American Airlines
Find Deal
Fri, Nov 14 - Thu, Nov 20
American Airlines Logo
6:24 pm - 9:56 pmTYS-SAF
5h 32m1 stop
American Airlines Logo
11:47 am - 11:50 pmSAF-TYS
10h 03m2 stops
$408American Airlines
Find Deal
Mon, Sep 15 - Mon, Sep 22
American Airlines Logo
5:43 am - 3:47 pmTYS-SAF
12h 04m2 stops
American Airlines Logo
8:11 am - 7:18 pmSAF-TYS
9h 07m2 stops
$416American Airlines
Find Deal
Thu, Jan 15 - Thu, Jan 22
American Airlines Logo
11:04 am - 8:00 pmTYS-SAF
10h 56m2 stops
American Airlines Logo
10:52 am - 9:39 pmSAF-TYS
8h 47m2 stops
$496American Airlines
Find Deal
Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
4:55 pm - 2:42 pmTYS-SAF
23h 47m1 stop
United Airlines Logo
7:00 am - 10:19 pmSAF-TYS
13h 19m1 stop
$608United Airlines
Find Deal
Fri, Nov 14 - Thu, Nov 20
United Airlines Logo
4:40 pm - 9:23 amTYS-SAF
18h 43m1 stop
United Airlines Logo
5:59 pm - 3:10 pmSAF-TYS
19h 11m1 stop
$622United Airlines
Find Deal
Mon, Sep 15 - Mon, Sep 22

United Airlines flights from Knoxville to Santa Fe

Our best United Airlines deals on Knoxville to Santa Fe flight tickets
United Airlines
Nov 14
TYS4:55 pmKnoxville McGhee Tyson
23h 47m
1 stop
SAF2:42 pmSanta Fe
Nov 20
SAF7:00 amSanta Fe
13h 19m
1 stop
TYS10:19 pmKnoxville McGhee Tyson
$608
Find similar
United Airlines
Sep 15
TYS4:40 pmKnoxville McGhee Tyson
18h 43m
1 stop
SAF9:23 amSanta Fe
Sep 22
SAF5:59 pmSanta Fe
19h 11m
1 stop
TYS3:10 pmKnoxville McGhee Tyson
$622
Find similar
United Airlines
Nov 14
TYS7:20 pmKnoxville McGhee Tyson
28h 39m
2 stops
SAF9:59 pmSanta Fe
Nov 20
SAF7:00 amSanta Fe
14h 59m
2 stops
TYS11:59 pmKnoxville McGhee Tyson
$638
Find similar

American Airlines flights from Knoxville to Santa Fe

Our best American Airlines deals on Knoxville to Santa Fe flight tickets
American Airlines
Jan 15
TYS5:43 amKnoxville McGhee Tyson
5h 38m
1 stop
SAF9:21 amSanta Fe
Jan 22
SAF10:43 amSanta Fe
4h 42m
1 stop
TYS5:25 pmKnoxville McGhee Tyson
$264
Find similar
American Airlines
Jan 15
TYS5:43 amKnoxville McGhee Tyson
5h 38m
1 stop
SAF9:21 amSanta Fe
Jan 22
SAF8:11 amSanta Fe
9h 07m
2 stops
TYS7:18 pmKnoxville McGhee Tyson
$274
Find similar
American Airlines
Feb 21
TYS3:00 pmKnoxville McGhee Tyson
7h 00m
1 stop
SAF8:00 pmSanta Fe
Feb 25
SAF6:03 amSanta Fe
7h 20m
1 stop
TYS3:23 pmKnoxville McGhee Tyson
$344
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 25, 2025.
Use the filters below to find and compare flights from Knoxville to Santa Fe that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Thu 1/15

5:43 am-9:21 am

1 stop5h 38m

Santa Fe

Thu 1/22

10:43 am-5:25 pm

1 stop4h 42m

$264

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Thu 1/15

5:43 am-9:21 am

1 stop5h 38m

Santa Fe

Thu 1/22

8:11 am-7:18 pm

2 stops9h 07m

$274

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 2/21

3:00 pm-8:00 pm

1 stop7h 00m

Santa Fe

Wed 2/25

6:03 am-3:23 pm

1 stop7h 20m

$344

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 2/21

5:51 am-9:26 am

1 stop5h 35m

Santa Fe

Wed 2/25

10:52 am-9:39 pm

2 stops8h 47m

$354

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Fri 11/14

4:27 pm-8:21 pm

1 stop5h 54m

Santa Fe

Thu 11/20

6:15 am-3:37 pm

1 stop7h 22m

$401

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Mon 9/15

6:24 pm-9:56 pm

1 stop5h 32m

Santa Fe

Mon 9/22

11:47 am-11:50 pm

2 stops10h 03m

$408

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Thu 1/15

5:43 am-3:47 pm

2 stops12h 04m

Santa Fe

Thu 1/22

8:11 am-7:18 pm

2 stops9h 07m

$416

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Sat 2/21

11:04 am-8:00 pm

2 stops10h 56m

Santa Fe

Wed 2/25

10:52 am-9:39 pm

2 stops8h 47m

$496

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Fri 11/14

4:55 pm-2:42 pm

1 stop23h 47m

Santa Fe

Thu 11/20

7:00 am-10:19 pm

1 stop13h 19m

$608

KnoxvilleSanta Fe

TYS - SAF

TYSSAF

Knoxville McGhee Tyson

Mon 9/15

4:40 pm-9:23 am

1 stop18h 43m

Santa Fe

Mon 9/22

5:59 pm-3:10 pm

1 stop19h 11m

$622

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Santa Fe

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Santa Fe?

According to our data, Saturday is the cheapest day to fly to Santa Fe from Knoxville. The lowest ticket price found for a Saturday departure recently was $349. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. Be sure to avoid booking your departure on a Wednesday as prices are generally higher than usual. According to our data, the average ticket price to Santa Fe on Wednesday is $472.

What is the cheapest time of day to depart on your flight to Santa Fe?

The cheapest time of day to fly to Santa Fe is in the morning when flights can be purchased for as low as $390. Try not to purchase tickets in the afternoon because they tend to be around $431. Of course, these prices can vary depending on the time of year and what airport you fly to.

When to book flights from Knoxville to Santa Fe

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Santa Fe according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Santa Fe (TYS to SAF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Santa Fe

Direct flights

None
There are no direct flights from Knoxville to Santa Fe. There are no popular flight routes from Knoxville to Santa Fe.
Search flight deals

  • How far is Knoxville McGhee Tyson to Santa Fe by plane?

    The straight-line distance from Knoxville McGhee Tyson to Santa Fe is 1230.1 mi. By plane, this route typically takes 5h 32m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Santa Fe Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Santa Fe Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Santa Fe Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Santa Fe Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Santa Fe Airport.

  • What documentation or ID do you need to fly to Santa Fe Airport?

    The required travel and health documents for your Santa Fe Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Santa Fe Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to Santa Fe?

Best airlines flying from Knoxville to Santa Fe

Compare and see reviews for airlines that fly from Knoxville to Santa Fe with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $264Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa
Los Alamos

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Santa Fe?

Finding the right flight to Santa Fe from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Santa Fe quick and easy, saving you time and money.

Can I find flights from Knoxville to Santa Fe with flexible booking policies on momondo?

momondo does allow users to show only those flights to Santa Fe from Knoxville which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Knoxville to Santa Fe?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Knoxville to Santa Fe.

I’m not ready to book a flight from Knoxville to Santa Fe right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Santa Fe from Knoxville. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Santa Fe trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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