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Cheap flights from Knoxville to Charleston from $138

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Charleston departing on 2/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:29 am - 5:36 pm
TYS
-
CHS
8h 07m1 stop
Multiple Airlines Logo
6:35 pm - 11:09 am
CHS
-
TYS
16h 34m1 stop
$190Multiple Airlines
Thu, Jan 29 - Fri, Jan 30
Multiple Airlines Logo
9:29 am - 5:36 pm
TYS
-
CHS
8h 07m1 stop
Multiple Airlines Logo
3:01 pm - 5:28 pm
CHS
-
TYS
26h 27m1 stop
$212Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Multiple Airlines Logo
9:29 am - 5:36 pm
TYS
-
CHS
8h 07m1 stop
Multiple Airlines Logo
7:00 am - 11:05 pm
CHS
-
TYS
16h 05m2 stops
$222Multiple Airlines
Thu, Jan 22 - Thu, Jan 29
Delta Logo
2:37 pm - 7:18 pm
TYS
-
CHS
4h 41m1 stop
Delta Logo
8:00 am - 11:08 am
CHS
-
TYS
3h 08m1 stop
$255Delta
Tue, Jan 27 - Wed, Jan 28
Multiple Airlines Logo
9:29 am - 10:55 pm
TYS
-
CHS
13h 26m2 stops
Multiple Airlines Logo
6:35 pm - 11:09 am
CHS
-
TYS
16h 34m1 stop
$261Multiple Airlines
Thu, Jan 29 - Fri, Jan 30
Multiple Airlines Logo
11:50 am - 10:06 pm
TYS
-
CHS
10h 16m2 stops
Multiple Airlines Logo
5:00 pm - 12:00 pm
CHS
-
TYS
19h 00m1 stop
$263Multiple Airlines
Thu, Feb 26 - Sun, Mar 1
Multiple Airlines Logo
11:50 am - 10:06 pm
TYS
-
CHS
10h 16m2 stops
Multiple Airlines Logo
5:00 pm - 12:00 pm
CHS
-
TYS
19h 00m1 stop
$268Multiple Airlines
Thu, Feb 26 - Sun, Mar 1
Multiple Airlines Logo
7:00 am - 5:40 pm
TYS
-
CHS
10h 40m1 stop
Multiple Airlines Logo
12:15 pm - 9:21 pm
CHS
-
TYS
33h 06m2 stops
$281Multiple Airlines
Sun, Feb 15 - Wed, Feb 18
American Airlines Logo
5:00 am - 8:33 am
TYS
-
CHS
3h 33m1 stop
American Airlines Logo
5:07 am - 11:17 am
CHS
-
TYS
6h 10m1 stop
$311American Airlines
Thu, Feb 26 - Sun, Mar 1
Multiple Airlines Logo
7:00 am - 5:40 pm
TYS
-
CHS
10h 40m1 stop
Multiple Airlines Logo
5:00 pm - 8:42 pm
CHS
-
TYS
27h 42m3 stops
$313Multiple Airlines
Sun, Feb 15 - Wed, Feb 18

American Airlines flights from Knoxville to Charleston

Our best American Airlines deals on Knoxville to Charleston flight tickets
American Airlines
Feb 26
TYS5:00 amKnoxville McGhee Tyson
3h 33m
1 stop
CHS8:33 amCharleston
Mar 1
CHS5:07 amCharleston
6h 10m
1 stop
TYS11:17 amKnoxville McGhee Tyson
$311
Find similar
American Airlines
Jan 16
TYS5:14 pmKnoxville McGhee Tyson
3h 57m
1 stop
CHS9:11 pmCharleston
Jan 19
CHS7:42 pmCharleston
3h 12m
1 stop
TYS10:54 pmKnoxville McGhee Tyson
$347
Find similar
American Airlines
Apr 23
TYS8:44 pmKnoxville McGhee Tyson
2h 44m
1 stop
CHS11:28 pmCharleston
Apr 26
CHS5:32 amCharleston
4h 56m
1 stop
TYS10:28 amKnoxville McGhee Tyson
$478
Find similar

Delta flights from Knoxville to Charleston

Our best Delta deals on Knoxville to Charleston flight tickets
Delta
Jan 27
TYS2:37 pmKnoxville McGhee Tyson
4h 41m
1 stop
CHS7:18 pmCharleston
Jan 28
CHS8:00 amCharleston
3h 08m
1 stop
TYS11:08 amKnoxville McGhee Tyson
$255
Find similar
Delta
Feb 15
TYS2:38 pmKnoxville McGhee Tyson
3h 16m
1 stop
CHS5:54 pmCharleston
Feb 18
CHS8:30 amCharleston
5h 21m
1 stop
TYS1:51 pmKnoxville McGhee Tyson
$376
Find similar
Delta
Jan 15
TYS11:05 amKnoxville McGhee Tyson
5h 01m
1 stop
CHS4:06 pmCharleston
Jan 18
CHS6:30 amCharleston
3h 45m
1 stop
TYS10:15 amKnoxville McGhee Tyson
$377
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/29

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Fri 1/30

6:35 pm-11:09 am

1 stop16h 34m

$190

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/22

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Thu 1/29

3:01 pm-5:28 pm

1 stop26h 27m

$212

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/22

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Thu 1/29

7:00 am-11:05 pm

2 stops16h 05m

$222

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 1/27

2:37 pm-7:18 pm

1 stop4h 41m

Charleston

Wed 1/28

8:00 am-11:08 am

1 stop3h 08m

$255

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/29

9:29 am-10:55 pm

2 stops13h 26m

Charleston

Fri 1/30

6:35 pm-11:09 am

1 stop16h 34m

$261

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 2/26

11:50 am-10:06 pm

2 stops10h 16m

Charleston

Sun 3/1

5:00 pm-12:00 pm

1 stop19h 00m

$263

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 2/26

11:50 am-10:06 pm

2 stops10h 16m

Charleston

Sun 3/1

5:00 pm-12:00 pm

1 stop19h 00m

$268

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sun 2/15

7:00 am-5:40 pm

1 stop10h 40m

Charleston

Wed 2/18

12:15 pm-9:21 pm

2 stops33h 06m

$281

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 2/26

5:00 am-8:33 am

1 stop3h 33m

Charleston

Sun 3/1

5:07 am-11:17 am

1 stop6h 10m

$311

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sun 2/15

7:00 am-5:40 pm

1 stop10h 40m

Charleston

Wed 2/18

5:00 pm-8:42 pm

3 stops27h 42m

$313

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Knoxville to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Charleston?

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Knoxville is in August. Flight prices, which tend to average around $320, are often lower during this time because this is during the off-season. The month of May is another great option to travel to Charleston, with average flight prices from Knoxville averaging around $366.

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Knoxville to Charleston is on a Saturday. Travelers who choose to depart for Charleston on a Saturday will often find tickets for as low as $456. The most expensive day to fly to Charleston is Monday, with ticket prices averaging around $678.

When to book flights from Knoxville to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Charleston (TYS to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Charleston

Fastest flight time

5h 01m

Direct flights

None
The fastest flight from Knoxville to Charleston takes 5h 01m
There are no direct flights from Knoxville to Charleston. There are no popular flight routes from Knoxville to Charleston.
Search flight deals

  • How far is Knoxville McGhee Tyson to Charleston by plane?

    The distance between Knoxville McGhee Tyson and Charleston is about 316.2 mi. A reasonable flight in good conditions will take 5h 01m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Charleston Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents you'll need for your trip to Charleston Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Charleston Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Charleston?

Best airlines flying from Knoxville to Charleston

Compare and see reviews for airlines that fly from Knoxville to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.2
11,072 reviews
Search American Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.9
8,019 reviews
Search Delta flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Charleston?

Finding the right flight to Charleston from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Charleston quick and easy, saving you time and money.

Can I find flights from Knoxville to Charleston with flexible booking policies on momondo?

All flight searches from Knoxville to Charleston on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Charleston?

momondo provides multiple filters to help you find the best flight to Charleston from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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