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Cheap flights from Knoxville to Charleston from $134

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Charleston departing on 4/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Knoxville to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:03 pm - 8:38 am
TYS
-
CHS
10h 35m
1 stop
Multiple Airlines Logo
9:28 pm - 10:42 am
CHS
-
TYS
13h 14m
1 stop
$261Multiple Airlines
Mon, Jun 22 - Mon, Jun 29
Multiple Airlines Logo
1:14 pm - 9:59 pm
TYS
-
CHS
8h 45m
1 stop
Multiple Airlines Logo
8:59 pm - 9:48 pm
CHS
-
TYS
24h 49m
1 stop
$278Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Southwest Logo
7:05 am - 12:25 pm
TYS
-
CHS
5h 20m
1 stop
Southwest Logo
2:25 pm - 8:50 pm
CHS
-
TYS
6h 25m
1 stop
$279Southwest
Tue, Apr 28 - Tue, May 5
Multiple Airlines Logo
5:00 pm - 9:38 am
TYS
-
CHS
16h 38m
1 stop
Multiple Airlines Logo
6:18 pm - 6:37 pm
CHS
-
TYS
24h 19m
1 stop
$280Multiple Airlines
Tue, May 26 - Sat, May 30
Multiple Airlines Logo
11:27 am - 8:38 am
TYS
-
CHS
45h 11m
2 stops
Multiple Airlines Logo
3:01 pm - 5:30 pm
CHS
-
TYS
26h 29m
1 stop
$283Multiple Airlines
Sun, Apr 19 - Thu, Apr 23
Southwest Logo
7:05 am - 12:25 pm
TYS
-
CHS
5h 20m
1 stop
Southwest Logo
12:00 pm - 8:50 pm
CHS
-
TYS
8h 50m
2 stops
$284Southwest
Tue, Apr 28 - Tue, May 5
Multiple Airlines Logo
1:14 pm - 9:59 pm
TYS
-
CHS
8h 45m
1 stop
Multiple Airlines Logo
8:59 pm - 9:48 pm
CHS
-
TYS
24h 49m
1 stop
$289Multiple Airlines
Thu, Apr 23 - Sun, Apr 26
Southwest Logo
8:15 am - 8:00 pm
TYS
-
CHS
11h 45m
2 stops
Southwest Logo
7:15 am - 7:40 pm
CHS
-
TYS
12h 25m
2 stops
$295Southwest
Tue, May 19 - Tue, May 26
Southwest Logo
7:45 am - 2:05 pm
TYS
-
CHS
6h 20m
1 stop
Southwest Logo
4:10 pm - 10:30 pm
CHS
-
TYS
6h 20m
1 stop
$299Southwest
Sat, May 30 - Thu, Jun 4
Multiple Airlines Logo
7:10 am - 1:44 pm
TYS
-
CHS
6h 34m
1 stop
Multiple Airlines Logo
2:38 pm - 9:50 pm
CHS
-
TYS
31h 12m
2 stops
$300Multiple Airlines
Sat, May 30 - Thu, Jun 4

Southwest flights from Knoxville to Charleston

Our best Southwest deals on Knoxville to Charleston flight tickets
Southwest
Apr 28
TYS7:05 amKnoxville McGhee Tyson
5h 20m
1 stop
CHS12:25 pmCharleston
May 5
CHS2:25 pmCharleston
6h 25m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
$279
Southwest
Apr 28
TYS7:05 amKnoxville McGhee Tyson
5h 20m
1 stop
CHS12:25 pmCharleston
May 5
CHS12:00 pmCharleston
8h 50m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
$284
Southwest
May 19
TYS8:15 amKnoxville McGhee Tyson
11h 45m
2 stops
CHS8:00 pmCharleston
May 26
CHS7:15 amCharleston
12h 25m
2 stops
TYS7:40 pmKnoxville McGhee Tyson
$295

Delta flights from Knoxville to Charleston

Our best Delta deals on Knoxville to Charleston flight tickets
Delta
May 8
TYS7:33 pmKnoxville McGhee Tyson
3h 23m
1 stop
CHS10:56 pmCharleston
May 13
CHS6:15 amCharleston
3h 19m
1 stop
TYS9:34 amKnoxville McGhee Tyson
$308
Delta
May 8
TYS7:33 pmKnoxville McGhee Tyson
3h 23m
1 stop
CHS10:56 pmCharleston
May 11
CHS7:59 pmCharleston
3h 57m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$318
Delta
May 1
TYS7:00 pmKnoxville McGhee Tyson
5h 22m
1 stop
CHS12:22 amCharleston
May 8
CHS7:59 pmCharleston
3h 57m
1 stop
TYS11:56 pmKnoxville McGhee Tyson
$352

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 5, 2026.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 6/22

10:03 pm-8:38 am

1 stop10h 35m

Charleston

Mon 6/29

9:28 pm-10:42 am

1 stop13h 14m

$261

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 4/23

1:14 pm-9:59 pm

1 stop8h 45m

Charleston

Sun 4/26

8:59 pm-9:48 pm

1 stop24h 49m

$278
Quickest round-trip

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 4/28

7:05 am-12:25 pm

1 stop5h 20m

Charleston

Tue 5/5

2:25 pm-8:50 pm

1 stop6h 25m

$279

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 5/26

5:00 pm-9:38 am

1 stop16h 38m

Charleston

Sat 5/30

6:18 pm-6:37 pm

1 stop24h 19m

$280

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sun 4/19

11:27 am-8:38 am

2 stops45h 11m

Charleston

Thu 4/23

3:01 pm-5:30 pm

1 stop26h 29m

$283

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 4/28

7:05 am-12:25 pm

1 stop5h 20m

Charleston

Tue 5/5

12:00 pm-8:50 pm

2 stops8h 50m

$284

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 4/23

1:14 pm-9:59 pm

1 stop8h 45m

Charleston

Sun 4/26

8:59 pm-9:48 pm

1 stop24h 49m

$289

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 5/19

8:15 am-8:00 pm

2 stops11h 45m

Charleston

Tue 5/26

7:15 am-7:40 pm

2 stops12h 25m

$295

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 5/30

7:45 am-2:05 pm

1 stop6h 20m

Charleston

Thu 6/4

4:10 pm-10:30 pm

1 stop6h 20m

$299

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 5/30

7:10 am-1:44 pm

1 stop6h 34m

Charleston

Thu 6/4

2:38 pm-9:50 pm

2 stops31h 12m

$300

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Knoxville to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Charleston?

When to book flights from Knoxville to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Charleston (TYS to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Charleston

Fastest flight time

3h 03m

Direct flights

None
The fastest flight from Knoxville to Charleston takes 3h 03m
There are no direct flights from Knoxville to Charleston. There are no popular flight routes from Knoxville to Charleston.
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Frequently asked questions about flying from Knoxville to Charleston

  • How far is Knoxville McGhee Tyson to Charleston by plane?

    The distance between Knoxville McGhee Tyson and Charleston is about 316.2 mi. A reasonable flight in good conditions will take 3h 03m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Charleston Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents you'll need for your trip to Charleston Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Charleston Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Charleston?

Best airlines flying from Knoxville to Charleston

Compare and see reviews for airlines that fly from Knoxville to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.1
11,555 reviews
Search American Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.9
8,386 reviews
Search Delta flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
Summerville
Kiawah Island
North Charleston
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Charleston?

Finding the right flight to Charleston from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Charleston quick and easy, saving you time and money.

Can I find flights from Knoxville to Charleston with flexible booking policies on momondo?

All flight searches from Knoxville to Charleston on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Charleston?

momondo provides multiple filters to help you find the best flight to Charleston from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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