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Cheap flights from Knoxville to Charleston from $116

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Charleston departing on 7/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
10:03 pm - 8:38 am
TYS
-
CHS
10h 35m
1 stop
Multiple Airlines Logo
3:23 pm - 11:33 pm
CHS
-
TYS
8h 10m
1 stop
$234Multiple Airlines
Mon, Jun 29 - Mon, Jul 13
Multiple Airlines Logo
7:27 pm - 8:38 am
TYS
-
CHS
13h 11m
1 stop
Multiple Airlines Logo
3:23 pm - 11:34 pm
CHS
-
TYS
8h 11m
1 stop
$240Multiple Airlines
Mon, Jun 8 - Fri, Jun 12
Multiple Airlines Logo
12:40 pm - 7:58 pm
TYS
-
CHS
31h 18m
2 stops
Multiple Airlines Logo
3:23 pm - 11:34 pm
CHS
-
TYS
8h 11m
1 stop
$266Multiple Airlines
Fri, Jun 5 - Fri, Jun 12
Multiple Airlines Logo
6:00 am - 8:38 am
TYS
-
CHS
26h 38m
2 stops
Multiple Airlines Logo
3:23 pm - 11:34 pm
CHS
-
TYS
8h 11m
1 stop
$269Multiple Airlines
Mon, Jun 8 - Fri, Jun 12
Multiple Airlines Logo
10:03 pm - 8:48 am
TYS
-
CHS
10h 45m
1 stop
Multiple Airlines Logo
3:23 pm - 11:34 pm
CHS
-
TYS
8h 11m
1 stop
$282Multiple Airlines
Fri, Jun 19 - Mon, Jun 29
Multiple Airlines Logo
12:40 pm - 7:58 pm
TYS
-
CHS
31h 18m
2 stops
Multiple Airlines Logo
3:23 pm - 11:34 pm
CHS
-
TYS
8h 11m
1 stop
$285Multiple Airlines
Fri, Jun 5 - Fri, Jun 12
Southwest Logo
8:10 am - 1:30 pm
TYS
-
CHS
5h 20m
1 stop
Southwest Logo
3:00 pm - 9:15 pm
CHS
-
TYS
6h 15m
1 stop
$295Southwest
Tue, Jun 23 - Tue, Jun 30
Southwest Logo
8:10 am - 8:25 pm
TYS
-
CHS
12h 15m
2 stops
Southwest Logo
2:10 pm - 8:20 pm
CHS
-
TYS
6h 10m
1 stop
$300Southwest
Tue, Jun 23 - Tue, Jun 30
Multiple Airlines Logo
7:27 pm - 8:48 am
TYS
-
CHS
13h 21m
1 stop
Multiple Airlines Logo
3:23 pm - 11:34 pm
CHS
-
TYS
8h 11m
1 stop
$306Multiple Airlines
Fri, Jun 5 - Fri, Jun 12
Multiple Airlines Logo
10:03 pm - 8:48 am
TYS
-
CHS
10h 45m
1 stop
Multiple Airlines Logo
9:28 pm - 10:55 pm
CHS
-
TYS
25h 27m
1 stop
$307Multiple Airlines
Fri, Jun 19 - Fri, Jun 26

Southwest flights from Knoxville to Charleston

Our best Southwest deals on Knoxville to Charleston flight tickets
Southwest
Jun 23
TYS8:10 amKnoxville McGhee Tyson
5h 20m
1 stop
CHS1:30 pmCharleston
Jun 30
CHS3:00 pmCharleston
6h 15m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
$295
Southwest
Jun 23
TYS8:10 amKnoxville McGhee Tyson
12h 15m
2 stops
CHS8:25 pmCharleston
Jun 30
CHS2:10 pmCharleston
6h 10m
1 stop
TYS8:20 pmKnoxville McGhee Tyson
$300
Southwest
Oct 6
TYS7:00 amKnoxville McGhee Tyson
5h 35m
1 stop
CHS12:35 pmCharleston
Oct 10
CHS6:40 amCharleston
5h 15m
1 stop
TYS11:55 amKnoxville McGhee Tyson
$308

Delta flights from Knoxville to Charleston

Our best Delta deals on Knoxville to Charleston flight tickets
Delta
Jul 7
TYS6:05 pmKnoxville McGhee Tyson
4h 02m
1 stop
CHS10:07 pmCharleston
Jul 11
CHS6:24 pmCharleston
5h 20m
1 stop
TYS11:44 pmKnoxville McGhee Tyson
$316
Delta
Sep 25
TYS5:30 amKnoxville McGhee Tyson
4h 13m
1 stop
CHS9:43 amCharleston
Sep 28
CHS5:55 pmCharleston
5h 52m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$329
Delta
Jun 19
TYS7:46 pmKnoxville McGhee Tyson
4h 59m
1 stop
CHS12:45 amCharleston
Jun 22
CHS6:15 amCharleston
3h 23m
1 stop
TYS9:38 amKnoxville McGhee Tyson
$357

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 6/29

10:03 pm-8:38 am

1 stop10h 35m

Charleston

Mon 7/13

3:23 pm-11:33 pm

1 stop8h 10m

$234

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 6/8

7:27 pm-8:38 am

1 stop13h 11m

Charleston

Fri 6/12

3:23 pm-11:34 pm

1 stop8h 11m

$240

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 6/5

12:40 pm-7:58 pm

2 stops31h 18m

Charleston

Fri 6/12

3:23 pm-11:34 pm

1 stop8h 11m

$266

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 6/8

6:00 am-8:38 am

2 stops26h 38m

Charleston

Fri 6/12

3:23 pm-11:34 pm

1 stop8h 11m

$269

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 6/19

10:03 pm-8:48 am

1 stop10h 45m

Charleston

Mon 6/29

3:23 pm-11:34 pm

1 stop8h 11m

$282

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 6/5

12:40 pm-7:58 pm

2 stops31h 18m

Charleston

Fri 6/12

3:23 pm-11:34 pm

1 stop8h 11m

$285
Quickest round-trip

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 6/23

8:10 am-1:30 pm

1 stop5h 20m

Charleston

Tue 6/30

3:00 pm-9:15 pm

1 stop6h 15m

$295

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 6/23

8:10 am-8:25 pm

2 stops12h 15m

Charleston

Tue 6/30

2:10 pm-8:20 pm

1 stop6h 10m

$300

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 6/5

7:27 pm-8:48 am

1 stop13h 21m

Charleston

Fri 6/12

3:23 pm-11:34 pm

1 stop8h 11m

$306

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 6/19

10:03 pm-8:48 am

1 stop10h 45m

Charleston

Fri 6/26

9:28 pm-10:55 pm

1 stop25h 27m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Knoxville to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Charleston?

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Knoxville is in December. Flight prices, which tend to average around $0, are often lower during this time because this is during the off-season. The month of August is another great option to travel to Charleston, with average flight prices from Knoxville averaging around $320.

When to book flights from Knoxville to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Charleston (TYS to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Charleston

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Knoxville to Charleston takes 4h 02m
There are no direct flights from Knoxville to Charleston. There are no popular flight routes from Knoxville to Charleston.
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Frequently asked questions about flying from Knoxville to Charleston

  • How far is Knoxville McGhee Tyson to Charleston by plane?

    The distance between Knoxville McGhee Tyson and Charleston is about 316.2 mi. A reasonable flight in good conditions will take 4h 02m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Charleston Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents you'll need for your trip to Charleston Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Charleston Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Charleston?

Best airlines flying from Knoxville to Charleston

Compare and see reviews for airlines that fly from Knoxville to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $279Free CancellationRating
7.1
11,631 reviews
Search American Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.9
8,436 reviews
Search Delta flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Summerville
Kiawah Island
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Charleston?

Finding the right flight to Charleston from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Charleston quick and easy, saving you time and money.

Can I find flights from Knoxville to Charleston with flexible booking policies on momondo?

All flight searches from Knoxville to Charleston on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Charleston?

momondo provides multiple filters to help you find the best flight to Charleston from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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