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Cheap flights from Knoxville to Charleston from $135

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Charleston departing on 5/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Knoxville to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
2:05 pm - 8:38 am
TYS
-
CHS
18h 33m
1 stop
Multiple Airlines Logo
6:35 pm - 9:40 am
CHS
-
TYS
15h 05m
1 stop
$237Multiple Airlines
Wed, Mar 4 - Fri, Mar 6
Multiple Airlines Logo
2:05 pm - 8:38 am
TYS
-
CHS
18h 33m
1 stop
Multiple Airlines Logo
6:35 pm - 10:26 pm
CHS
-
TYS
27h 51m
1 stop
$242Multiple Airlines
Wed, Mar 4 - Sat, Mar 7
Multiple Airlines Logo
2:05 pm - 8:38 am
TYS
-
CHS
18h 33m
1 stop
Multiple Airlines Logo
6:35 pm - 10:10 am
CHS
-
TYS
15h 35m
1 stop
$258Multiple Airlines
Wed, Mar 4 - Mon, Mar 9
Multiple Airlines Logo
2:05 pm - 8:38 am
TYS
-
CHS
18h 33m
1 stop
Multiple Airlines Logo
6:35 pm - 11:01 am
CHS
-
TYS
16h 26m
1 stop
$260Multiple Airlines
Wed, Mar 4 - Sun, Mar 8
Multiple Airlines Logo
1:15 pm - 8:38 am
TYS
-
CHS
19h 23m
1 stop
Multiple Airlines Logo
7:00 am - 2:45 pm
CHS
-
TYS
7h 45m
1 stop
$269Multiple Airlines
Mon, Apr 20 - Thu, Apr 23
Southwest Logo
7:45 am - 2:05 pm
TYS
-
CHS
6h 20m
1 stop
Southwest Logo
2:25 pm - 8:50 pm
CHS
-
TYS
6h 25m
1 stop
$271Southwest
Sat, Apr 11 - Wed, Apr 15
Multiple Airlines Logo
2:05 pm - 8:38 am
TYS
-
CHS
18h 33m
1 stop
Multiple Airlines Logo
8:59 pm - 1:16 pm
CHS
-
TYS
16h 17m
2 stops
$273Multiple Airlines
Wed, Mar 4 - Sun, Mar 8
Multiple Airlines Logo
9:43 pm - 10:13 pm
TYS
-
CHS
24h 30m
1 stop
Multiple Airlines Logo
8:07 am - 8:08 am
CHS
-
TYS
24h 01m
1 stop
$276Multiple Airlines
Thu, Mar 12 - Thu, Mar 19
Delta Logo
5:35 am - 9:23 am
TYS
-
CHS
3h 48m
1 stop
Delta Logo
6:30 am - 11:17 am
CHS
-
TYS
4h 47m
1 stop
$279Delta
Wed, Mar 4 - Tue, Mar 10
Southwest Logo
6:40 am - 2:05 pm
TYS
-
CHS
7h 25m
2 stops
Southwest Logo
12:00 pm - 8:50 pm
CHS
-
TYS
8h 50m
2 stops
$281Southwest
Sat, Apr 11 - Wed, Apr 15

Southwest flights from Knoxville to Charleston

Our best Southwest deals on Knoxville to Charleston flight tickets
Southwest
Apr 11
TYS7:45 amKnoxville McGhee Tyson
6h 20m
1 stop
CHS2:05 pmCharleston
Apr 15
CHS2:25 pmCharleston
6h 25m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
$271
Southwest
Apr 11
TYS6:40 amKnoxville McGhee Tyson
7h 25m
2 stops
CHS2:05 pmCharleston
Apr 15
CHS12:00 pmCharleston
8h 50m
2 stops
TYS8:50 pmKnoxville McGhee Tyson
$281
Southwest
Apr 24
TYS6:35 amKnoxville McGhee Tyson
12h 45m
2 stops
CHS7:20 pmCharleston
Apr 25
CHS7:35 amCharleston
7h 45m
1 stop
TYS3:20 pmKnoxville McGhee Tyson
$309

Delta flights from Knoxville to Charleston

Our best Delta deals on Knoxville to Charleston flight tickets
Delta
Mar 4
TYS5:35 amKnoxville McGhee Tyson
3h 48m
1 stop
CHS9:23 amCharleston
Mar 11
CHS6:30 amCharleston
4h 47m
1 stop
TYS11:17 amKnoxville McGhee Tyson
$279
Delta
Mar 12
TYS5:40 amKnoxville McGhee Tyson
3h 01m
1 stop
CHS8:41 amCharleston
Mar 19
CHS5:27 amCharleston
3h 49m
1 stop
TYS9:16 amKnoxville McGhee Tyson
$303
Delta
Mar 9
TYS6:38 pmKnoxville McGhee Tyson
5h 38m
1 stop
CHS12:16 amCharleston
Mar 11
CHS5:27 amCharleston
5h 50m
1 stop
TYS11:17 amKnoxville McGhee Tyson
$319

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 13, 2026.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 3/4

2:05 pm-8:38 am

1 stop18h 33m

Charleston

Fri 3/6

6:35 pm-9:40 am

1 stop15h 05m

$237

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 3/4

2:05 pm-8:38 am

1 stop18h 33m

Charleston

Sat 3/7

6:35 pm-10:26 pm

1 stop27h 51m

$242

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 3/4

2:05 pm-8:38 am

1 stop18h 33m

Charleston

Mon 3/9

6:35 pm-10:10 am

1 stop15h 35m

$258

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 3/4

2:05 pm-8:38 am

1 stop18h 33m

Charleston

Sun 3/8

6:35 pm-11:01 am

1 stop16h 26m

$260

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 4/20

1:15 pm-8:38 am

1 stop19h 23m

Charleston

Thu 4/23

7:00 am-2:45 pm

1 stop7h 45m

$269

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 4/11

7:45 am-2:05 pm

1 stop6h 20m

Charleston

Wed 4/15

2:25 pm-8:50 pm

1 stop6h 25m

$271

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 3/4

2:05 pm-8:38 am

1 stop18h 33m

Charleston

Sun 3/8

8:59 pm-1:16 pm

2 stops16h 17m

$273

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 3/12

9:43 pm-10:13 pm

1 stop24h 30m

Charleston

Thu 3/19

8:07 am-8:08 am

1 stop24h 01m

$276

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 3/4

5:35 am-9:23 am

1 stop3h 48m

Charleston

Tue 3/10

6:30 am-11:17 am

1 stop4h 47m

$279

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sat 4/11

6:40 am-2:05 pm

2 stops7h 25m

Charleston

Wed 4/15

12:00 pm-8:50 pm

2 stops8h 50m

$281

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

When to book flights from Knoxville to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Charleston (TYS to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Charleston

Fastest flight time

3h 01m

Direct flights

None
The fastest flight from Knoxville to Charleston takes 3h 01m
There are no direct flights from Knoxville to Charleston. There are no popular flight routes from Knoxville to Charleston.
Search flight deals

  • How far is Knoxville McGhee Tyson to Charleston by plane?

    The distance between Knoxville McGhee Tyson and Charleston is about 316.2 mi. A reasonable flight in good conditions will take 3h 01m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Charleston Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents you'll need for your trip to Charleston Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Charleston Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Charleston?

Best airlines flying from Knoxville to Charleston

Compare and see reviews for airlines that fly from Knoxville to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $286Free CancellationRating
7.2
11,288 reviews
Search American Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.9
8,203 reviews
Search Delta flights

  • How do I get Price Alerts for flights from Knoxville to Charleston?

    Search flight deals from Knoxville to Charleston. While viewing offers you’ll have the option to create a Price Alert.

  • How can I save money on flights from Knoxville to Charleston with momondo?

    With “Price Forecast”, learn how soon you should book your flight in advance. Down to the day of week and time of day, our information can inform you on the ideal time to book to save on your travel. Our “Price Calendar” shows you at a quick glance when to book your travel for lower rates. By setting “Price Alerts” you can monitor changes in price and target the ideal time to book. Search for your trip destination by budget amount via our “Explore” feature. Whether you’re looking for ideas for your next travel adventure or cost-cutting tips, our “Discover” content is a great place to start.

  • How does momondo find its flight prices?

    We aggregate our prices from over 700+ competitors from airlines to OTAs. We operate in over 30 markets worldwide to show you a wide range of travel options.

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
Kiawah Island
North Charleston
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Charleston?

Finding the right flight to Charleston from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Charleston quick and easy, saving you time and money.

Can I find flights from Knoxville to Charleston with flexible booking policies on momondo?

All flight searches from Knoxville to Charleston on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Charleston?

momondo provides multiple filters to help you find the best flight to Charleston from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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