Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Knoxville to Charleston from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Charleston departing on 12/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Knoxville to Charleston

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:23 am - 8:54 pmTYS-CHS
11h 31m1 stop
Multiple Airlines Logo
9:49 pm - 8:33 amCHS-TYS
10h 44m1 stop
$240Multiple Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Delta Logo
5:40 am - 9:27 amTYS-CHS
3h 47m1 stop
Delta Logo
3:30 pm - 6:58 pmCHS-TYS
3h 28m1 stop
$263Delta
Find Deal
Wed, Dec 10 - Wed, Dec 17
American Airlines Logo
7:23 pm - 11:13 pmTYS-CHS
3h 50m1 stop
American Airlines Logo
9:25 am - 4:33 pmCHS-TYS
7h 08m1 stop
$272American Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
Multiple Airlines Logo
9:23 am - 11:00 amTYS-CHS
25h 37m2 stops
Multiple Airlines Logo
9:49 pm - 8:33 amCHS-TYS
10h 44m1 stop
$273Multiple Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Multiple Airlines Logo
9:29 am - 5:36 pmTYS-CHS
8h 07m1 stop
Multiple Airlines Logo
3:01 pm - 3:57 pmCHS-TYS
24h 56m2 stops
$292Multiple Airlines
Find Deal
Thu, Jan 29 - Tue, Feb 3
Multiple Airlines Logo
9:23 am - 11:00 amTYS-CHS
25h 37m3 stops
Multiple Airlines Logo
9:49 pm - 8:33 amCHS-TYS
10h 44m1 stop
$299Multiple Airlines
Find Deal
Fri, Dec 5 - Sun, Dec 7
Multiple Airlines Logo
9:23 am - 8:54 pmTYS-CHS
11h 31m1 stop
Multiple Airlines Logo
5:48 pm - 9:44 pmCHS-TYS
27h 56m2 stops
$300Multiple Airlines
Find Deal
Mon, Dec 8 - Wed, Dec 10
American Airlines Logo
4:12 pm - 7:28 pmTYS-CHS
3h 16m1 stop
American Airlines Logo
8:08 pm - 11:52 pmCHS-TYS
3h 44m1 stop
$304American Airlines
Find Deal
Thu, Dec 18 - Sat, Dec 20
Multiple Airlines Logo
8:53 am - 9:23 pmTYS-CHS
12h 30m1 stop
Multiple Airlines Logo
10:18 pm - 8:18 amCHS-TYS
10h 00m1 stop
$308Multiple Airlines
Find Deal
Fri, Dec 19 - Sun, Dec 21
Multiple Airlines Logo
9:08 am - 9:23 pmTYS-CHS
12h 15m1 stop
Multiple Airlines Logo
10:18 pm - 8:18 amCHS-TYS
10h 00m1 stop
$309Multiple Airlines
Find Deal
Mon, Dec 22 - Mon, Dec 29

American Airlines flights from Knoxville to Charleston

Our best American Airlines deals on Knoxville to Charleston flight tickets
American Airlines
Dec 8
TYS7:23 pmKnoxville McGhee Tyson
3h 50m
1 stop
CHS11:13 pmCharleston
Dec 10
CHS9:25 amCharleston
7h 08m
1 stop
TYS4:33 pmKnoxville McGhee Tyson
$272
Find similar
American Airlines
Dec 16
TYS7:23 pmKnoxville McGhee Tyson
3h 50m
1 stop
CHS11:13 pmCharleston
Dec 30
CHS8:08 pmCharleston
3h 39m
1 stop
TYS11:47 pmKnoxville McGhee Tyson
$285
Find similar
American Airlines
Dec 18
TYS4:12 pmKnoxville McGhee Tyson
3h 16m
1 stop
CHS7:28 pmCharleston
Dec 20
CHS8:08 pmCharleston
3h 44m
1 stop
TYS11:52 pmKnoxville McGhee Tyson
$304
Find similar

United Airlines flights from Knoxville to Charleston

Our best United Airlines deals on Knoxville to Charleston flight tickets
United Airlines
Dec 18
TYS5:45 amKnoxville McGhee Tyson
13h 33m
2 stops
CHS7:18 pmCharleston
Dec 20
CHS7:46 pmCharleston
19h 02m
1 stop
TYS2:48 pmKnoxville McGhee Tyson
$729
Find similar
United Airlines
Apr 23
TYS7:00 amKnoxville McGhee Tyson
16h 43m
2 stops
CHS11:43 pmCharleston
Apr 26
CHS6:00 amCharleston
9h 08m
1 stop
TYS3:08 pmKnoxville McGhee Tyson
$849
Find similar
United Airlines
Apr 23
TYS7:00 amKnoxville McGhee Tyson
16h 20m
1 stop
CHS11:20 pmCharleston
Apr 26
CHS6:00 amCharleston
14h 46m
2 stops
TYS8:46 pmKnoxville McGhee Tyson
$861
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/5

9:23 am-8:54 pm

1 stop11h 31m

Charleston

Sun 12/7

9:49 pm-8:33 am

1 stop10h 44m

$240

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 12/10

5:40 am-9:27 am

1 stop3h 47m

Charleston

Wed 12/17

3:30 pm-6:58 pm

1 stop3h 28m

$263

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/8

7:23 pm-11:13 pm

1 stop3h 50m

Charleston

Wed 12/10

9:25 am-4:33 pm

1 stop7h 08m

$272

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/5

9:23 am-11:00 am

2 stops25h 37m

Charleston

Sun 12/7

9:49 pm-8:33 am

1 stop10h 44m

$273

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 1/29

9:29 am-5:36 pm

1 stop8h 07m

Charleston

Tue 2/3

3:01 pm-3:57 pm

2 stops24h 56m

$292

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/5

9:23 am-11:00 am

3 stops25h 37m

Charleston

Sun 12/7

9:49 pm-8:33 am

1 stop10h 44m

$299

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/8

9:23 am-8:54 pm

1 stop11h 31m

Charleston

Wed 12/10

5:48 pm-9:44 pm

2 stops27h 56m

$300

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Thu 12/18

4:12 pm-7:28 pm

1 stop3h 16m

Charleston

Sat 12/20

8:08 pm-11:52 pm

1 stop3h 44m

$304

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 12/19

8:53 am-9:23 pm

1 stop12h 30m

Charleston

Sun 12/21

10:18 pm-8:18 am

1 stop10h 00m

$308

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 12/22

9:08 am-9:23 pm

1 stop12h 15m

Charleston

Mon 12/29

10:18 pm-8:18 am

1 stop10h 00m

$309

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Charleston from

How to get the cheapest flight ticket from Knoxville to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Knoxville is in August. Flight prices, which tend to average around $320, are often lower during this time because this is during the off-season. The month of May is another great option to travel to Charleston, with average flight prices from Knoxville averaging around $366.

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Knoxville to Charleston is on a Saturday. Travelers who choose to depart for Charleston on a Saturday will often find tickets for as low as $456. The most expensive day to fly to Charleston is Monday, with ticket prices averaging around $678.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the morning when flights can be purchased for as low as $478. In the afternoon is when there is more demand to fly to Charleston, so prices are often more expensive at around $588 per ticket.

When to book flights from Knoxville to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Charleston (TYS to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Charleston

Direct flights

None
There are no direct flights from Knoxville to Charleston. There are no popular flight routes from Knoxville to Charleston.
Search flight deals

  • How far is Knoxville McGhee Tyson to Charleston by plane?

    The distance between Knoxville McGhee Tyson and Charleston is about 316.2 mi. A reasonable flight in good conditions will take 2h 44m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Charleston Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents you'll need for your trip to Charleston Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Charleston Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Charleston?

Best airlines flying from Knoxville to Charleston

Compare and see reviews for airlines that fly from Knoxville to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.2
11,051 reviews
Search American Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.9
8,007 reviews
Search Delta flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Santee
Walterboro
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Charleston?

Finding the right flight to Charleston from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Charleston quick and easy, saving you time and money.

Can I find flights from Knoxville to Charleston with flexible booking policies on momondo?

All flight searches from Knoxville to Charleston on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Charleston?

momondo provides multiple filters to help you find the best flight to Charleston from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Charleston trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Sat 12/13
Sat 12/20
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States