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Cheap flights from Knoxville to Charleston from $111

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Charleston departing on 10/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Knoxville to Charleston

Cheap round-trip flights

Multiple Airlines Logo
4:32 pm - 10:45 amTYS-CHS
18h 13m1 stop
Multiple Airlines Logo
5:40 pm - 9:04 amCHS-TYS
15h 24m1 stop
$215Multiple Airlines
Find Deal
Wed, Nov 5 - Sat, Nov 8
Multiple Airlines Logo
4:32 pm - 10:45 amTYS-CHS
18h 13m1 stop
Multiple Airlines Logo
5:40 pm - 9:04 amCHS-TYS
15h 24m1 stop
$238Multiple Airlines
Find Deal
Wed, Nov 12 - Sat, Nov 15
Delta Logo
3:53 pm - 8:42 pmTYS-CHS
4h 49m1 stop
Delta Logo
3:30 pm - 6:59 pmCHS-TYS
3h 29m1 stop
$317Delta
Find Deal
Mon, Nov 10 - Wed, Dec 10
Delta Logo
2:27 pm - 6:00 pmTYS-CHS
3h 33m1 stop
Delta Logo
5:35 am - 9:25 amCHS-TYS
3h 50m1 stop
$327Delta
Find Deal
Tue, Oct 21 - Tue, Oct 28
American Airlines Logo
7:43 pm - 11:08 pmTYS-CHS
3h 25m1 stop
American Airlines Logo
12:15 pm - 4:51 pmCHS-TYS
4h 36m1 stop
$406American Airlines
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Wed, Oct 8 - Wed, Oct 15
American Airlines Logo
6:30 am - 12:11 pmTYS-CHS
5h 41m1 stop
American Airlines Logo
6:45 am - 12:59 pmCHS-TYS
6h 14m1 stop
$412American Airlines
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Sun, Nov 23 - Sat, Nov 29
Allegiant Air Logo
8:44 pm - 3:41 pmTYS-CHS
18h 57m2 stops
Allegiant Air Logo
9:38 pm - 11:19 pmCHS-TYS
25h 41m2 stops
$481Allegiant Air
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Fri, Oct 10 - Sun, Oct 12
United Airlines Logo
7:26 pm - 4:40 pmTYS-CHS
21h 14m2 stops
United Airlines Logo
10:00 am - 11:59 pmCHS-TYS
13h 59m1 stop
$582United Airlines
Find Deal
Tue, Oct 21 - Tue, Oct 28
United Airlines Logo
7:26 pm - 2:07 pmTYS-CHS
18h 41m2 stops
United Airlines Logo
7:47 pm - 2:45 pmCHS-TYS
18h 58m1 stop
$622United Airlines
Find Deal
Tue, Oct 21 - Fri, Oct 24
Allegiant Air Logo
8:30 am - 8:44 pmTYS-CHS
12h 14m2 stops
Allegiant Air Logo
3:15 pm - 12:30 pmCHS-TYS
21h 15m2 stops
$823Allegiant Air
Find Deal
Sun, Nov 23 - Sat, Nov 29

American Airlines flights from Knoxville to Charleston

Our best American Airlines deals on Knoxville to Charleston flight tickets
American Airlines
Oct 7
TYS8:15 amKnoxville McGhee Tyson
3h 20m
1 stop
CHS11:35 amCharleston
Oct 13
CHS6:36 pmCharleston
5h 14m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
$406
Find similar
American Airlines
Nov 23
TYS6:30 amKnoxville McGhee Tyson
5h 41m
1 stop
CHS12:11 pmCharleston
Nov 29
CHS6:45 amCharleston
6h 14m
1 stop
TYS12:59 pmKnoxville McGhee Tyson
$412
Find similar
American Airlines
Sep 26
TYS5:19 pmKnoxville McGhee Tyson
5h 42m
1 stop
CHS11:01 pmCharleston
Sep 27
CHS5:26 pmCharleston
3h 24m
1 stop
TYS8:50 pmKnoxville McGhee Tyson
$491
Find similar

United Airlines flights from Knoxville to Charleston

Our best United Airlines deals on Knoxville to Charleston flight tickets
United Airlines
Oct 21
TYS7:26 pmKnoxville McGhee Tyson
21h 14m
2 stops
CHS4:40 pmCharleston
Oct 28
CHS10:00 amCharleston
13h 59m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
$582
Find similar
United Airlines
Oct 21
TYS7:26 pmKnoxville McGhee Tyson
18h 41m
2 stops
CHS2:07 pmCharleston
Oct 24
CHS7:47 pmCharleston
18h 58m
1 stop
TYS2:45 pmKnoxville McGhee Tyson
$622
Find similar
United Airlines
Oct 8
TYS2:16 pmKnoxville McGhee Tyson
19h 44m
1 stop
CHS10:00 amCharleston
Oct 15
CHS11:31 amCharleston
11h 19m
1 stop
TYS10:50 pmKnoxville McGhee Tyson
$635
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Knoxville to Charleston that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 25, 2025.
Use the filters below to find and compare flights from Knoxville to Charleston that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 11/5

4:32 pm-10:45 am

1 stop18h 13m

Charleston

Sat 11/8

5:40 pm-9:04 am

1 stop15h 24m

$215

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 11/12

4:32 pm-10:45 am

1 stop18h 13m

Charleston

Sat 11/15

5:40 pm-9:04 am

1 stop15h 24m

$238

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Mon 11/10

3:53 pm-8:42 pm

1 stop4h 49m

Charleston

Wed 12/10

3:30 pm-6:59 pm

1 stop3h 29m

$317

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 10/21

2:27 pm-6:00 pm

1 stop3h 33m

Charleston

Tue 10/28

5:35 am-9:25 am

1 stop3h 50m

$327

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Wed 10/8

7:43 pm-11:08 pm

1 stop3h 25m

Charleston

Wed 10/15

12:15 pm-4:51 pm

1 stop4h 36m

$406

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sun 11/23

6:30 am-12:11 pm

1 stop5h 41m

Charleston

Sat 11/29

6:45 am-12:59 pm

1 stop6h 14m

$412

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Fri 10/10

8:44 pm-3:41 pm

2 stops18h 57m

Charleston

Sun 10/12

9:38 pm-11:19 pm

2 stops25h 41m

$481

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 10/21

7:26 pm-4:40 pm

2 stops21h 14m

Charleston

Tue 10/28

10:00 am-11:59 pm

1 stop13h 59m

$582

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Tue 10/21

7:26 pm-2:07 pm

2 stops18h 41m

Charleston

Fri 10/24

7:47 pm-2:45 pm

1 stop18h 58m

$622

KnoxvilleCharleston

TYS - CHS

TYSCHS

Knoxville McGhee Tyson

Sun 11/23

8:30 am-8:44 pm

2 stops12h 14m

Charleston

Sat 11/29

3:15 pm-12:30 pm

2 stops21h 15m

$823

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Charleston from

How to get the cheapest flight ticket from Knoxville to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Knoxville and Charleston?

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Knoxville is in August. Flight prices, which tend to average around $320, are often lower during this time because this is during the off-season. The month of May is another great option to travel to Charleston, with average flight prices from Knoxville averaging around $366.

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Knoxville to Charleston is on a Saturday. Travelers who choose to depart for Charleston on a Saturday will often find tickets for as low as $456. The most expensive day to fly to Charleston is Monday, with ticket prices averaging around $678.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the morning when flights can be purchased for as low as $478. In the afternoon is when there is more demand to fly to Charleston, so prices are often more expensive at around $588 per ticket.

When to book flights from Knoxville to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Charleston (TYS to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Charleston

Direct flights

None
There are no direct flights from Knoxville to Charleston. There are no popular flight routes from Knoxville to Charleston.
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  • How far is Knoxville McGhee Tyson to Charleston by plane?

    The distance between Knoxville McGhee Tyson and Charleston is about 316.2 mi. A reasonable flight in good conditions will take 3h 09m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Charleston Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Charleston Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Charleston Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents you'll need for your trip to Charleston Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Charleston Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Charleston?

Best airlines flying from Knoxville to Charleston

Compare and see reviews for airlines that fly from Knoxville to Charleston with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $296Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
DeltaPriceFrom $316Free CancellationRating
7.9
7,973 reviews
Search Delta flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
Isle of Palms
North Charleston
Kiawah Island
Summerville
Mount Pleasant
Edisto Island
Walterboro
Santee
Goose Creek
Edisto Beach
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Charleston?

Finding the right flight to Charleston from Knoxville is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Charleston quick and easy, saving you time and money.

Can I find flights from Knoxville to Charleston with flexible booking policies on momondo?

All flight searches from Knoxville to Charleston on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Knoxville to Charleston?

momondo provides multiple filters to help you find the best flight to Charleston from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to Charleston right now. Can momondo alert me if prices change?

Price alerts on flights to Charleston from Knoxville are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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