Cheap flights from Key West to Knoxville from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 8/14. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

Delta Logo
1:57 pm - 8:10 pmEYW-TYS
6h 13m1 stop
Delta Logo
3:48 pm - 8:06 pmTYS-EYW
4h 18m1 stop
$339Delta
Find Deal
Thu, Oct 16 - Mon, Oct 20
American Airlines Logo
7:52 pm - 11:35 pmEYW-TYS
3h 43m1 stop
American Airlines Logo
7:00 am - 5:16 pmTYS-EYW
10h 16m2 stops
$368American Airlines
Find Deal
Thu, Oct 16 - Mon, Oct 20
Delta Logo
7:00 am - 10:44 amEYW-TYS
3h 44m1 stop
Delta Logo
1:53 pm - 8:12 pmTYS-EYW
6h 19m1 stop
$389Delta
Find Deal
Thu, Aug 14 - Thu, Aug 21
American Airlines Logo
5:47 pm - 11:50 pmEYW-TYS
6h 03m2 stops
American Airlines Logo
7:00 am - 12:55 pmTYS-EYW
5h 55m2 stops
$398American Airlines
Find Deal
Thu, Oct 16 - Mon, Oct 20
American Airlines Logo
11:26 am - 7:45 pmEYW-TYS
8h 19m2 stops
American Airlines Logo
7:00 am - 12:58 pmTYS-EYW
5h 58m1 stop
$476American Airlines
Find Deal
Thu, Aug 14 - Thu, Aug 21
American Airlines Logo
11:26 am - 7:45 pmEYW-TYS
8h 19m2 stops
American Airlines Logo
5:06 am - 12:58 pmTYS-EYW
7h 52m2 stops
$512American Airlines
Find Deal
Thu, Aug 14 - Thu, Aug 21
United Airlines Logo
2:22 pm - 10:37 pmEYW-TYS
32h 15m3 stops
United Airlines Logo
7:25 pm - 2:25 pmTYS-EYW
19h 00m2 stops
$773United Airlines
Find Deal
Thu, Aug 14 - Thu, Aug 21

Delta flights from Key West to Knoxville

Our best Delta deals on Key West to Knoxville flight tickets
Delta
Oct 16
EYW1:57 pmKey West
6h 13m
1 stop
TYS8:10 pmKnoxville McGhee Tyson
Oct 20
TYS3:48 pmKnoxville McGhee Tyson
4h 18m
1 stop
EYW8:06 pmKey West
Delta
Aug 14
EYW7:00 amKey West
3h 44m
1 stop
TYS10:44 amKnoxville McGhee Tyson
Aug 21
TYS1:53 pmKnoxville McGhee Tyson
6h 19m
1 stop
EYW8:12 pmKey West

American Airlines flights from Key West to Knoxville

Our best American Airlines deals on Key West to Knoxville flight tickets
American Airlines
Oct 16
EYW7:52 pmKey West
3h 43m
1 stop
TYS11:35 pmKnoxville McGhee Tyson
Oct 20
TYS7:00 amKnoxville McGhee Tyson
10h 16m
2 stops
EYW5:16 pmKey West
American Airlines
Oct 16
EYW5:47 pmKey West
6h 03m
2 stops
TYS11:50 pmKnoxville McGhee Tyson
Oct 20
TYS7:00 amKnoxville McGhee Tyson
5h 55m
2 stops
EYW12:55 pmKey West
American Airlines
Aug 14
EYW11:26 amKey West
8h 19m
2 stops
TYS7:45 pmKnoxville McGhee Tyson
Aug 21
TYS7:00 amKnoxville McGhee Tyson
5h 58m
1 stop
EYW12:58 pmKey West

momondo Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 2, 2025.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 10/16

1:57 pm-8:10 pm

1 stop6h 13m

Knoxville McGhee Tyson

Mon 10/20

3:48 pm-8:06 pm

1 stop4h 18m

$339

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 10/16

7:52 pm-11:35 pm

1 stop3h 43m

Knoxville McGhee Tyson

Mon 10/20

7:00 am-5:16 pm

2 stops10h 16m

$368

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

7:00 am-10:44 am

1 stop3h 44m

Knoxville McGhee Tyson

Thu 8/21

1:53 pm-8:12 pm

1 stop6h 19m

$389

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 10/16

5:47 pm-11:50 pm

2 stops6h 03m

Knoxville McGhee Tyson

Mon 10/20

7:00 am-12:55 pm

2 stops5h 55m

$398

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

11:26 am-7:45 pm

2 stops8h 19m

Knoxville McGhee Tyson

Thu 8/21

7:00 am-12:58 pm

1 stop5h 58m

$476

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

11:26 am-7:45 pm

2 stops8h 19m

Knoxville McGhee Tyson

Thu 8/21

5:06 am-12:58 pm

2 stops7h 52m

$512

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

2:22 pm-10:37 pm

3 stops32h 15m

Knoxville McGhee Tyson

Thu 8/21

7:25 pm-2:25 pm

2 stops19h 00m

$773

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/14

3:00 pm-7:24 pm

1 stop4h 24m

$129

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/7

3:01 pm-11:37 pm

1 stop8h 36m

$169

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 8/8

7:00 am-1:51 pm

1 stop6h 51m

$239

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 15 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Key West to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Key West to Knoxville is on a Wednesday. Travelers who choose to depart for Knoxville on a Wednesday will often find tickets for as low as $365. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Key West to Knoxville for around $846.

What is the cheapest time of day to depart on your flight to Knoxville?

In the afternoon is the cheapest time of day to fly from Key West to Knoxville when you can find flight prices for as low as $529. Flying to Knoxville in the afternoon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $596.

When to book flights from Key West to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to Knoxville (EYW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to Knoxville

Best Price Found

$129

Fastest flight time

3h 43m

Direct flights

None

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Key West in the past 72 hours is $129. The best round-trip flight deal from Key West to Knoxville found on momondo in the last 72 hours is $339.
The fastest flight from Key West to Knoxville takes 3h 43m
There are no direct flights from Key West to Knoxville. Popular non-direct route for this connection is Key West Airport - Knoxville McGhee Tyson Airport.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)

  • How far is Key West to Knoxville McGhee Tyson by plane?

    Key West and Knoxville McGhee Tyson are 797.5 mi apart from one another. A reasonable flight in good conditions will take 3h 43m.

  • When did momondo last update prices for flights from Key West Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Key West Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Key West Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Key West to Knoxville?

  • What is the most popular airline from Key West to Knoxville?


Best airlines flying from Key West to Knoxville

Compare and see reviews for airlines that fly from Key West to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $253Free CancellationRating
8.0
7,985 reviews
Search Delta flights
American AirlinesPriceFrom $258Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Newport
Alcoa
Lenoir City
Oak Ridge
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Key West to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Key West to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Key West to Knoxville with flexible booking policies on momondo?

Flights from Key West to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Key West to Knoxville?

momondo helps you find the best flight between Key West and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Key West. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.


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1 adult
Thu 8/7
Thu 8/14

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