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Cheap flights from Key West to Knoxville from $45

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 7/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Key West to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:31 am - 12:46 pm
EYW
-
TYS
2h 15mnonstop
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
$73Allegiant Air
Fri, Jul 31 - Mon, Aug 3
Allegiant Air Logo
3:27 pm - 9:15 pm
EYW
-
TYS
5h 48m
1 stop
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
$134Allegiant Air
Fri, Jul 31 - Mon, Aug 3
Multiple Airlines Logo
7:53 pm - 11:19 pm
EYW
-
TYS
27h 26m
1 stop
Multiple Airlines Logo
3:53 pm - 2:37 pm
TYS
-
EYW
22h 44m
1 stop
$220Multiple Airlines
Thu, Jul 9 - Thu, Jul 16
Allegiant Air Logo
3:27 pm - 9:15 pm
EYW
-
TYS
5h 48m
1 stop
Allegiant Air Logo
8:30 am - 3:51 pm
TYS
-
EYW
7h 21m
1 stop
$223Allegiant Air
Fri, Jul 31 - Mon, Aug 3
Multiple Airlines Logo
10:31 am - 12:46 pm
EYW
-
TYS
2h 15mnonstop
Multiple Airlines Logo
12:40 pm - 12:34 pm
TYS
-
EYW
23h 54m
3 stops
$229Multiple Airlines
Fri, Jul 31 - Mon, Aug 3
Allegiant Air Logo
5:00 pm - 12:30 pm
EYW
-
TYS
19h 30m
1 stop
Allegiant Air Logo
6:42 pm - 3:27 pm
TYS
-
EYW
20h 45m
1 stop
$239Allegiant Air
Wed, Jul 15 - Sat, Jul 18
Allegiant Air Logo
5:00 pm - 12:30 pm
EYW
-
TYS
19h 30m
1 stop
Allegiant Air Logo
8:15 am - 3:27 pm
TYS
-
EYW
7h 12m
1 stop
$283Allegiant Air
Wed, Jul 15 - Sun, Jul 19
Multiple Airlines Logo
7:53 pm - 11:19 pm
EYW
-
TYS
27h 26m
1 stop
Multiple Airlines Logo
9:11 pm - 3:51 pm
TYS
-
EYW
18h 40m
2 stops
$287Multiple Airlines
Thu, Jul 9 - Thu, Jul 16
Multiple Airlines Logo
11:46 am - 8:21 pm
EYW
-
TYS
32h 35m
2 stops
Multiple Airlines Logo
8:15 am - 3:27 pm
TYS
-
EYW
7h 12m
1 stop
$289Multiple Airlines
Wed, Jul 15 - Sun, Jul 19
Allegiant Air Logo
7:22 pm - 8:59 pm
EYW
-
TYS
25h 37m
1 stop
Allegiant Air Logo
11:00 am - 1:12 pm
TYS
-
EYW
2h 12mnonstop
$290Allegiant Air
Thu, Dec 10 - Mon, Dec 14

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Allegiant Air flights from Key West to Knoxville

Our best Allegiant Air deals on Key West to Knoxville flight tickets
Allegiant Air
Jul 31
EYW10:31 amKey West
2h 15m
TYS12:46 pmKnoxville McGhee Tyson
Aug 3
TYS7:30 amKnoxville McGhee Tyson
2h 11m
EYW9:41 amKey West
$73
Allegiant Air
Jul 31
EYW3:27 pmKey West
5h 48m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Aug 3
TYS7:30 amKnoxville McGhee Tyson
2h 11m
EYW9:41 amKey West
$134
Allegiant Air
Jul 31
EYW3:27 pmKey West
5h 48m
1 stop
TYS9:15 pmKnoxville McGhee Tyson
Aug 3
TYS8:30 amKnoxville McGhee Tyson
7h 21m
1 stop
EYW3:51 pmKey West
$223

American Airlines flights from Key West to Knoxville

Our best American Airlines deals on Key West to Knoxville flight tickets
American Airlines
Jun 17
EYW11:28 amKey West
6h 09m
2 stops
TYS5:37 pmKnoxville McGhee Tyson
Jun 21
TYS6:55 amKnoxville McGhee Tyson
5h 21m
1 stop
EYW12:16 pmKey West
$523
American Airlines
Jun 17
EYW11:28 amKey West
6h 09m
2 stops
TYS5:37 pmKnoxville McGhee Tyson
Jun 21
TYS6:55 amKnoxville McGhee Tyson
5h 21m
1 stop
EYW12:16 pmKey West
$538
American Airlines
Jun 17
EYW11:28 amKey West
6h 09m
2 stops
TYS5:37 pmKnoxville McGhee Tyson
Jun 20
TYS6:55 amKnoxville McGhee Tyson
5h 21m
1 stop
EYW12:16 pmKey West
$562

momondo Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 16, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 7/31

10:31 am-12:46 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Mon 8/3

7:30 am-9:41 am

Nonstop2h 11m

$73

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 7/31

3:27 pm-9:15 pm

1 stop5h 48m

Knoxville McGhee Tyson

Mon 8/3

7:30 am-9:41 am

Nonstop2h 11m

$134

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 7/9

7:53 pm-11:19 pm

1 stop27h 26m

Knoxville McGhee Tyson

Thu 7/16

3:53 pm-2:37 pm

1 stop22h 44m

$220

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 7/31

3:27 pm-9:15 pm

1 stop5h 48m

Knoxville McGhee Tyson

Mon 8/3

8:30 am-3:51 pm

1 stop7h 21m

$223

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 7/31

10:31 am-12:46 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Mon 8/3

12:40 pm-12:34 pm

3 stops23h 54m

$229

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 7/15

5:00 pm-12:30 pm

1 stop19h 30m

Knoxville McGhee Tyson

Sat 7/18

6:42 pm-3:27 pm

1 stop20h 45m

$239

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 7/15

5:00 pm-12:30 pm

1 stop19h 30m

Knoxville McGhee Tyson

Sun 7/19

8:15 am-3:27 pm

1 stop7h 12m

$283

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 7/9

7:53 pm-11:19 pm

1 stop27h 26m

Knoxville McGhee Tyson

Thu 7/16

9:11 pm-3:51 pm

2 stops18h 40m

$287

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 7/15

11:46 am-8:21 pm

2 stops32h 35m

Knoxville McGhee Tyson

Sun 7/19

8:15 am-3:27 pm

1 stop7h 12m

$289

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

7:22 pm-8:59 pm

1 stop25h 37m

Knoxville McGhee Tyson

Mon 12/14

11:00 am-1:12 pm

Nonstop2h 12m

$290

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Key West to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Key West and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from Key West, with most prices found around $0. If you aren’t able to travel during the month of April, then book flights to Knoxville from Key West during February instead. Flights to Knoxville in February, while not as cheap as those in April, still average around $0.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Key West to Knoxville is on a Friday. Travelers who choose to depart for Knoxville on a Friday will often find tickets for as low as $144. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Key West to Knoxville for around $169.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Key West to Knoxville when you can find flight prices for as low as $143. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $171.

What is the cheapest Key West to Knoxville McGhee Tyson flight route?

Fly from Key West to Knoxville McGhee Tyson for the best Key West - Knoxville McGhee Tyson flight prices

What cabin class options are available on Key West to Knoxville flights?

There is only 1 cabin class available to choose from on Key West to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Key West to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Key West to Knoxville.

When to book flights from Key West to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to Knoxville (EYW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to Knoxville

Fastest flight time

2h 15m

Direct flights

Tue and Sat

Airports in Knoxville

1 airport
The fastest flight from Key West to Knoxville takes 2h 15m
Direct flights go from Key West to Knoxville on Tuesday and Saturday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From Key West there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from Key West to Knoxville

  • How far is Key West to Knoxville McGhee Tyson by plane?

    Key West and Knoxville McGhee Tyson are 797.5 mi apart from one another. A reasonable flight in good conditions will take 2h 15m.

  • When did momondo last update prices for flights from Key West Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Key West Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Key West Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Key West to Knoxville?

  • What is the most popular airline from Key West to Knoxville?

Best airlines flying from Key West to Knoxville

Compare and see reviews for airlines that fly from Key West to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $92Free CancellationRating
7.3
694 reviews
Search Allegiant Air flights

  • Allegiant Air Flights From Key West to Knoxville

    Allegiant Air operates around 2 flights from Key West to Knoxville every week. The average price of these flights found in the last 72 hours has been $169, but momondo users have found Allegiant Air deals from Key West to Knoxville from as low as $92 round-trip. Allegiant Air has been scored 7.3/10 in 694 reviews.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Murphy
Crossville
Oak Ridge
Lenoir City
Kodak
Newport
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Key West to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Key West to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Key West to Knoxville with flexible booking policies on momondo?

Flights from Key West to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Key West to Knoxville?

momondo helps you find the best flight between Key West and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Key West. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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