Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Key West to Knoxville from $166

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 4/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Key West to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:25 pm - 10:36 am
EYW
-
TYS
22h 11m
1 stop
Multiple Airlines Logo
1:45 pm - 2:52 pm
TYS
-
EYW
25h 07m
1 stop
$302Multiple Airlines
Tue, Mar 31 - Sat, Apr 4
Multiple Airlines Logo
1:01 pm - 10:36 am
EYW
-
TYS
21h 35m
2 stops
Multiple Airlines Logo
1:45 pm - 2:52 pm
TYS
-
EYW
25h 07m
1 stop
$321Multiple Airlines
Tue, Mar 31 - Sat, Apr 4
American Airlines Logo
7:42 pm - 11:59 pm
EYW
-
TYS
4h 17m
1 stop
American Airlines Logo
3:58 pm - 10:36 pm
TYS
-
EYW
6h 38m
1 stop
$471American Airlines
Mon, Mar 30 - Fri, Apr 10
Delta Logo
6:25 pm - 11:57 pm
EYW
-
TYS
5h 32m
1 stop
Delta Logo
5:40 am - 10:48 am
TYS
-
EYW
5h 08m
1 stop
$473Delta
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
7:42 pm - 11:59 pm
EYW
-
TYS
4h 17m
1 stop
American Airlines Logo
2:06 pm - 10:58 pm
TYS
-
EYW
8h 52m
2 stops
$568American Airlines
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
12:55 pm - 8:05 pm
EYW
-
TYS
7h 10m
1 stop
American Airlines Logo
3:58 pm - 10:58 pm
TYS
-
EYW
7h 00m
2 stops
$608American Airlines
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
4:20 pm - 11:55 pm
EYW
-
TYS
7h 35m
1 stop
American Airlines Logo
5:57 pm - 10:36 pm
TYS
-
EYW
4h 39m
1 stop
$669American Airlines
Mon, Apr 20 - Mon, Apr 27
American Airlines Logo
4:20 pm - 10:24 pm
EYW
-
TYS
6h 04m
1 stop
American Airlines Logo
3:58 pm - 10:58 pm
TYS
-
EYW
7h 00m
2 stops
$674American Airlines
Mon, Apr 20 - Mon, Apr 27
United Airlines Logo
6:22 pm - 10:08 am
EYW
-
TYS
15h 46m
2 stops
United Airlines Logo
7:20 pm - 5:39 pm
TYS
-
EYW
22h 19m
2 stops
$732United Airlines
Mon, Apr 20 - Mon, Apr 27
United Airlines Logo
6:22 pm - 10:08 am
EYW
-
TYS
15h 46m
2 stops
United Airlines Logo
7:00 am - 3:57 pm
TYS
-
EYW
32h 57m
2 stops
$742United Airlines
Mon, Apr 20 - Mon, Apr 27

United Airlines flights from Key West to Knoxville

Our best United Airlines deals on Key West to Knoxville flight tickets
United Airlines
Apr 20
EYW6:22 pmKey West
15h 46m
2 stops
TYS10:08 amKnoxville McGhee Tyson
Apr 27
TYS7:20 pmKnoxville McGhee Tyson
22h 19m
2 stops
EYW5:39 pmKey West
$732
United Airlines
Apr 20
EYW6:22 pmKey West
15h 46m
2 stops
TYS10:08 amKnoxville McGhee Tyson
Apr 27
TYS7:00 amKnoxville McGhee Tyson
32h 57m
2 stops
EYW3:57 pmKey West
$742
United Airlines
Apr 2
EYW4:38 pmKey West
27h 18m
1 stop
TYS7:56 pmKnoxville McGhee Tyson
Apr 5
TYS11:25 amKnoxville McGhee Tyson
28h 32m
1 stop
EYW3:57 pmKey West
$757

American Airlines flights from Key West to Knoxville

Our best American Airlines deals on Key West to Knoxville flight tickets
American Airlines
Mar 30
EYW7:42 pmKey West
4h 17m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Apr 10
TYS3:58 pmKnoxville McGhee Tyson
6h 38m
1 stop
EYW10:36 pmKey West
$471
American Airlines
Mar 30
EYW7:42 pmKey West
4h 17m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Apr 10
TYS2:06 pmKnoxville McGhee Tyson
8h 52m
2 stops
EYW10:58 pmKey West
$568
American Airlines
Mar 30
EYW12:55 pmKey West
7h 10m
1 stop
TYS8:05 pmKnoxville McGhee Tyson
Apr 10
TYS3:58 pmKnoxville McGhee Tyson
7h 00m
2 stops
EYW10:58 pmKey West
$608

momondo Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 3/31

12:25 pm-10:36 am

1 stop22h 11m

Knoxville McGhee Tyson

Sat 4/4

1:45 pm-2:52 pm

1 stop25h 07m

$302

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 3/31

1:01 pm-10:36 am

2 stops21h 35m

Knoxville McGhee Tyson

Sat 4/4

1:45 pm-2:52 pm

1 stop25h 07m

$321

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 3/30

7:42 pm-11:59 pm

1 stop4h 17m

Knoxville McGhee Tyson

Fri 4/10

3:58 pm-10:36 pm

1 stop6h 38m

$471
Quickest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 3/30

6:25 pm-11:57 pm

1 stop5h 32m

Knoxville McGhee Tyson

Fri 4/10

5:40 am-10:48 am

1 stop5h 08m

$473

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 3/30

7:42 pm-11:59 pm

1 stop4h 17m

Knoxville McGhee Tyson

Fri 4/10

2:06 pm-10:58 pm

2 stops8h 52m

$568

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 3/30

12:55 pm-8:05 pm

1 stop7h 10m

Knoxville McGhee Tyson

Fri 4/10

3:58 pm-10:58 pm

2 stops7h 00m

$608

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 4/20

4:20 pm-11:55 pm

1 stop7h 35m

Knoxville McGhee Tyson

Mon 4/27

5:57 pm-10:36 pm

1 stop4h 39m

$669

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 4/20

4:20 pm-10:24 pm

1 stop6h 04m

Knoxville McGhee Tyson

Mon 4/27

3:58 pm-10:58 pm

2 stops7h 00m

$674

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 4/20

6:22 pm-10:08 am

2 stops15h 46m

Knoxville McGhee Tyson

Mon 4/27

7:20 pm-5:39 pm

2 stops22h 19m

$732

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 4/20

6:22 pm-10:08 am

2 stops15h 46m

Knoxville McGhee Tyson

Mon 4/27

7:00 am-3:57 pm

2 stops32h 57m

$742

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 13 resultsSorted by cheapest first
1
2

See travel insights to Knoxville from

How to get the cheapest flight ticket from Key West to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Key West to Knoxville when you can find flight prices for as low as $143. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $184.

What is the cheapest Key West to Knoxville McGhee Tyson flight route?

Fly from Key West to Knoxville McGhee Tyson for the best Key West - Knoxville McGhee Tyson flight prices

What cabin class options are available on Key West to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Key West to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Key West to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Key West to Knoxville.

When to book flights from Key West to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to Knoxville (EYW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to Knoxville

Fastest flight time

3h 42m

Direct flights

None
The fastest flight from Key West to Knoxville takes 3h 42m
There are no direct flights from Key West to Knoxville. There are no popular flight routes from Key West to Knoxville.
Search flight deals

  • How far is Key West to Knoxville McGhee Tyson by plane?

    Key West and Knoxville McGhee Tyson are 797.5 mi apart from one another. A reasonable flight in good conditions will take 3h 42m.

  • When did momondo last update prices for flights from Key West Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Key West Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Key West Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Key West to Knoxville?

  • What is the most popular airline from Key West to Knoxville?

Best airlines flying from Key West to Knoxville

Compare and see reviews for airlines that fly from Key West to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $248Free CancellationRating
7.1
11,467 reviews
Search American Airlines flights
DeltaPriceFrom $273Free CancellationRating
7.9
8,296 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Jefferson City
Dandridge
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Key West to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Key West to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Key West to Knoxville with flexible booking policies on momondo?

Flights from Key West to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Key West to Knoxville?

momondo helps you find the best flight between Key West and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Key West. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your Knoxville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Wed 4/15
Wed 4/22
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States