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Cheap flights from Key West to Knoxville from $136

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 4/23. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Cheap round-trip flights

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Allegiant Air Logo
EYW
-
TYS
2h 15mnonstop
Allegiant Air Logo
TYS
-
EYW
2h 11mnonstop
Allegiant Air

United Airlines flights from Key West to Knoxville

Our best United Airlines deals on Key West to Knoxville flight tickets
United Airlines
Feb 5
EYW6:05 pmKey West
16h 52m
1 stop
TYS10:57 amKnoxville McGhee Tyson
Feb 8
TYS7:20 pmKnoxville McGhee Tyson
21h 02m
1 stop
EYW4:22 pmKey West
$597
United Airlines
Feb 5
EYW2:25 pmKey West
20h 32m
2 stops
TYS10:57 amKnoxville McGhee Tyson
Feb 8
TYS7:20 pmKnoxville McGhee Tyson
21h 02m
1 stop
EYW4:22 pmKey West
$603
United Airlines
Feb 5
EYW6:05 pmKey West
25h 22m
1 stop
TYS7:27 pmKnoxville McGhee Tyson
Feb 8
TYS7:20 pmKnoxville McGhee Tyson
21h 02m
1 stop
EYW4:22 pmKey West
$647

momondo Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 4/23

3:03 pm-10:33 pm

1 stop7h 30m

$136

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 3/3

1:01 pm-10:10 am

2 stops21h 09m

$152

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sun 2/22

4:09 pm-10:34 am

1 stop18h 25m

$166

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 2/16

9:49 am-10:08 am

2 stops48h 19m

$178

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Tue 3/3

1:01 pm-6:26 pm

3 stops29h 25m

$187

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 2/16

11:01 am-1:16 pm

Nonstop2h 15m

$206

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Mon 2/16

3:47 pm-3:14 pm

1 stop23h 27m

$209

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 4/23

12:15 pm-5:30 pm

2 stops29h 15m

$212

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sun 7/5

8:48 pm-2:58 pm

1 stop18h 10m

$226

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sun 2/22

2:25 pm-10:05 pm

2 stops31h 40m

$237

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Key West to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Key West to Knoxville when you can find flight prices for as low as $143. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $203.

What is the cheapest Key West to Knoxville McGhee Tyson flight route?

Fly from Key West to Knoxville McGhee Tyson for the best Key West - Knoxville McGhee Tyson flight prices

What cabin class options are available on Key West to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Key West to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Key West to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Key West to Knoxville.

When to book flights from Key West to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to Knoxville (EYW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to Knoxville

Fastest flight time

2h 15m

Direct flights

Tue

Airports in Knoxville

1 airport
The fastest flight from Key West to Knoxville takes 2h 15m
Direct flights go from Key West to Knoxville on Tuesday. There are no airlines offering direct flights.
There is 1 airport in Knoxville. From Key West there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

  • How far is Key West to Knoxville McGhee Tyson by plane?

    Key West and Knoxville McGhee Tyson are 797.5 mi apart from one another. A reasonable flight in good conditions will take 2h 15m.

  • When did momondo last update prices for flights from Key West Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Key West Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Key West Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Key West to Knoxville?

  • What is the most popular airline from Key West to Knoxville?

Best airlines flying from Key West to Knoxville

Compare and see reviews for airlines that fly from Key West to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $273Free CancellationRating
7.9
8,128 reviews
Search Delta flights
American AirlinesPriceFrom $298Free CancellationRating
7.2
11,205 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Murphy
Alcoa
Maryville
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Key West to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Key West to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Key West to Knoxville with flexible booking policies on momondo?

Flights from Key West to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Key West to Knoxville?

momondo helps you find the best flight between Key West and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Key West. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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