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Cheap flights from Key West to Knoxville from $124

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 1/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Cheap round-trip flights

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Allegiant Air Logo
5:41 pm - 7:56 pmEYW-TYS
2h 15mnonstop
Allegiant Air Logo
2:40 pm - 4:51 pmTYS-EYW
2h 11mnonstop
$124Allegiant Air
Find Deal
Fri, Jan 16 - Mon, Jan 19
Allegiant Air Logo
3:46 pm - 10:10 amEYW-TYS
18h 24m1 stop
Allegiant Air Logo
2:40 pm - 4:51 pmTYS-EYW
2h 11mnonstop
$197Allegiant Air
Find Deal
Thu, Jan 15 - Mon, Jan 19
Multiple Airlines Logo
5:41 pm - 7:56 pmEYW-TYS
2h 15mnonstop
Multiple Airlines Logo
4:47 pm - 1:30 pmTYS-EYW
20h 43m1 stop
$199Multiple Airlines
Find Deal
Fri, Jan 16 - Wed, Jan 21
Multiple Airlines Logo
5:41 pm - 7:56 pmEYW-TYS
2h 15mnonstop
Multiple Airlines Logo
4:47 pm - 10:21 amTYS-EYW
17h 34m2 stops
$260Multiple Airlines
Find Deal
Fri, Jan 16 - Wed, Jan 21
Delta Logo
1:28 pm - 8:22 pmEYW-TYS
6h 54m1 stop
Delta Logo
6:00 am - 12:48 pmTYS-EYW
6h 48m1 stop
$266Delta
Find Deal
Fri, Jan 16 - Tue, Jan 20
American Airlines Logo
7:45 pm - 11:59 pmEYW-TYS
4h 14m1 stop
American Airlines Logo
4:00 pm - 11:56 pmTYS-EYW
7h 56m2 stops
$297American Airlines
Find Deal
Fri, Jan 16 - Tue, Jan 20
American Airlines Logo
7:45 pm - 11:59 pmEYW-TYS
4h 14m1 stop
American Airlines Logo
5:17 pm - 9:47 pmTYS-EYW
4h 30m1 stop
$301American Airlines
Find Deal
Thu, Jan 15 - Tue, Jan 20
Delta Logo
6:17 pm - 11:07 pmEYW-TYS
4h 50m1 stop
Delta Logo
3:59 pm - 8:06 pmTYS-EYW
4h 07m1 stop
$769Delta
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Sat, Nov 1 - Sun, Nov 2
United Airlines Logo
3:09 pm - 11:59 pmEYW-TYS
32h 50m2 stops
United Airlines Logo
7:23 pm - 4:29 pmTYS-EYW
21h 06m1 stop
$817United Airlines
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Wed, Dec 24 - Fri, Dec 26
United Airlines Logo
3:00 pm - 11:05 amEYW-TYS
20h 05m2 stops
United Airlines Logo
5:52 pm - 2:04 pmTYS-EYW
20h 12m2 stops
$1,244United Airlines
Find Deal
Sat, Nov 1 - Sun, Nov 2

Allegiant Air flights from Key West to Knoxville

Our best Allegiant Air deals on Key West to Knoxville flight tickets
Allegiant Air
Jan 16
EYW5:41 pmKey West
2h 15m
TYS7:56 pmKnoxville McGhee Tyson
Jan 19
TYS2:40 pmKnoxville McGhee Tyson
2h 11m
EYW4:51 pmKey West
$124
Find similar
Allegiant Air
Jan 15
EYW3:46 pmKey West
18h 24m
1 stop
TYS10:10 amKnoxville McGhee Tyson
Jan 19
TYS2:40 pmKnoxville McGhee Tyson
2h 11m
EYW4:51 pmKey West
$197
Find similar
Allegiant Air
Jan 17
EYW1:01 pmKey West
23h 48m
1 stop
TYS12:49 pmKnoxville McGhee Tyson
Jan 19
TYS2:40 pmKnoxville McGhee Tyson
2h 11m
EYW4:51 pmKey West
$212
Find similar

Delta flights from Key West to Knoxville

Our best Delta deals on Key West to Knoxville flight tickets
Delta
Jan 16
EYW1:28 pmKey West
6h 54m
1 stop
TYS8:22 pmKnoxville McGhee Tyson
Jan 20
TYS6:00 amKnoxville McGhee Tyson
6h 48m
1 stop
EYW12:48 pmKey West
$266
Find similar
Delta
Nov 1
EYW6:17 pmKey West
4h 50m
1 stop
TYS11:07 pmKnoxville McGhee Tyson
Nov 2
TYS3:59 pmKnoxville McGhee Tyson
4h 07m
1 stop
EYW8:06 pmKey West
$769
Find similar
Delta
Nov 1
EYW6:17 pmKey West
4h 50m
1 stop
TYS11:07 pmKnoxville McGhee Tyson
Nov 2
TYS3:59 pmKnoxville McGhee Tyson
4h 07m
1 stop
EYW8:06 pmKey West
$809
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 27, 2025.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

5:41 pm-7:56 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Mon 1/19

2:40 pm-4:51 pm

Nonstop2h 11m

$124

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 1/15

3:46 pm-10:10 am

1 stop18h 24m

Knoxville McGhee Tyson

Mon 1/19

2:40 pm-4:51 pm

Nonstop2h 11m

$197

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

5:41 pm-7:56 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Wed 1/21

4:47 pm-1:30 pm

1 stop20h 43m

$199

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

5:41 pm-7:56 pm

Nonstop2h 15m

Knoxville McGhee Tyson

Wed 1/21

4:47 pm-10:21 am

2 stops17h 34m

$260

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

1:28 pm-8:22 pm

1 stop6h 54m

Knoxville McGhee Tyson

Tue 1/20

6:00 am-12:48 pm

1 stop6h 48m

$266

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 1/16

7:45 pm-11:59 pm

1 stop4h 14m

Knoxville McGhee Tyson

Tue 1/20

4:00 pm-11:56 pm

2 stops7h 56m

$297

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 1/15

7:45 pm-11:59 pm

1 stop4h 14m

Knoxville McGhee Tyson

Tue 1/20

5:17 pm-9:47 pm

1 stop4h 30m

$301

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 11/1

6:17 pm-11:07 pm

1 stop4h 50m

Knoxville McGhee Tyson

Sun 11/2

3:59 pm-8:06 pm

1 stop4h 07m

$769

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Wed 12/24

3:09 pm-11:59 pm

2 stops32h 50m

Knoxville McGhee Tyson

Fri 12/26

7:23 pm-4:29 pm

1 stop21h 06m

$817

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Sat 11/1

3:00 pm-11:05 am

2 stops20h 05m

Knoxville McGhee Tyson

Sun 11/2

5:52 pm-2:04 pm

2 stops20h 12m

$1,244

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Key West to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Key West and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of October is, on average, the cheapest month to fly to Knoxville from Key West, with most prices found around $203. If you aren’t able to travel during the month of October, then book flights to Knoxville from Key West during January instead. Flights to Knoxville in January, while not as cheap as those in October, still average around $253.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Key West to Knoxville is on a Friday. Travelers who choose to depart for Knoxville on a Friday will often find tickets for as low as $203. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Key West to Knoxville for around $846.

What is the cheapest time of day to depart on your flight to Knoxville?

In the morning is the cheapest time of day to fly from Key West to Knoxville when you can find flight prices for as low as $203. Flying to Knoxville in the morning is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the evening when prices are around $596.

What is the cheapest Key West to Knoxville McGhee Tyson flight route?

Fly from Key West to Knoxville McGhee Tyson for the best Key West - Knoxville McGhee Tyson flight prices

What cabin class options are available on Key West to Knoxville McGhee Tyson flights?

There is only 1 cabin class available to choose from on Key West to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Key West to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Key West to Knoxville.

When to book flights from Key West to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to Knoxville (EYW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to Knoxville

Fastest flight time

2h 15m

Direct flights

Sat

Airports in Knoxville

1 airport
The fastest flight from Key West to Knoxville takes 2h 15m
Direct flights go from Key West to Knoxville on Saturday. There are no airlines offering direct flights.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)
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  • How far is Key West to Knoxville McGhee Tyson by plane?

    Key West and Knoxville McGhee Tyson are 797.5 mi apart from one another. A reasonable flight in good conditions will take 2h 15m.

  • When did momondo last update prices for flights from Key West Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Key West Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Key West Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Key West to Knoxville?

  • What is the most popular airline from Key West to Knoxville?

Best airlines flying from Key West to Knoxville

Compare and see reviews for airlines that fly from Key West to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $253Free CancellationRating
7.9
7,996 reviews
Search Delta flights
American AirlinesPriceFrom $298Free CancellationRating
7.2
11,033 reviews
Search American Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Key West to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Key West to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Key West to Knoxville with flexible booking policies on momondo?

Flights from Key West to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Key West to Knoxville?

momondo helps you find the best flight between Key West and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Key West. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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