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Cheap flights from Key West to Knoxville from $65

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 11/6. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Key West to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
8:00 am - 2:29 pm
EYW
-
TYS
6h 29m
1 stop
American Airlines Logo
2:55 pm - 9:45 pm
TYS
-
EYW
6h 50m
1 stop
$319American Airlines
Thu, Dec 10 - Mon, Dec 14
Delta Logo
7:35 am - 11:29 am
EYW
-
TYS
3h 54m
1 stop
Delta Logo
6:00 am - 10:48 am
TYS
-
EYW
4h 48m
1 stop
$319Delta
Thu, Dec 10 - Mon, Dec 14
American Airlines Logo
4:10 pm - 11:57 pm
EYW
-
TYS
7h 47m
2 stops
American Airlines Logo
2:55 pm - 9:45 pm
TYS
-
EYW
6h 50m
1 stop
$572American Airlines
Thu, Dec 10 - Mon, Dec 14
American Airlines Logo
4:10 pm - 11:57 pm
EYW
-
TYS
7h 47m
2 stops
American Airlines Logo
2:55 pm - 9:45 pm
TYS
-
EYW
6h 50m
1 stop
$573American Airlines
Thu, Dec 10 - Mon, Dec 14
United Airlines Logo
2:30 pm - 9:59 am
EYW
-
TYS
19h 29m
2 stops
United Airlines Logo
7:35 pm - 1:02 pm
TYS
-
EYW
17h 27m
2 stops
$769United Airlines
Thu, Dec 10 - Mon, Dec 14
United Airlines Logo
2:30 pm - 10:00 am
EYW
-
TYS
19h 30m
2 stops
United Airlines Logo
7:35 pm - 1:02 pm
TYS
-
EYW
17h 27m
2 stops
$776United Airlines
Thu, Dec 10 - Mon, Dec 14
United Airlines Logo
2:15 pm - 4:58 pm
EYW
-
TYS
26h 43m
2 stops
United Airlines Logo
7:20 pm - 1:29 pm
TYS
-
EYW
18h 09m
2 stops
$1,266United Airlines
Fri, Aug 14 - Mon, Aug 17

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American Airlines flights from Key West to Knoxville

Our best American Airlines deals on Key West to Knoxville flight tickets
American Airlines
Dec 10
EYW4:10 pmKey West
7h 47m
2 stops
TYS11:57 pmKnoxville McGhee Tyson
Dec 14
TYS2:55 pmKnoxville McGhee Tyson
6h 50m
1 stop
EYW9:45 pmKey West
$572
American Airlines
Dec 10
EYW4:10 pmKey West
7h 47m
2 stops
TYS11:57 pmKnoxville McGhee Tyson
Dec 14
TYS2:55 pmKnoxville McGhee Tyson
6h 50m
1 stop
EYW9:45 pmKey West
$573

United Airlines flights from Key West to Knoxville

Our best United Airlines deals on Key West to Knoxville flight tickets
United Airlines
Dec 10
EYW2:30 pmKey West
19h 29m
2 stops
TYS9:59 amKnoxville McGhee Tyson
Dec 14
TYS7:35 pmKnoxville McGhee Tyson
17h 27m
2 stops
EYW1:02 pmKey West
$769
United Airlines
Dec 10
EYW2:30 pmKey West
19h 30m
2 stops
TYS10:00 amKnoxville McGhee Tyson
Dec 14
TYS7:35 pmKnoxville McGhee Tyson
17h 27m
2 stops
EYW1:02 pmKey West
$776
United Airlines
Aug 14
EYW2:15 pmKey West
26h 43m
2 stops
TYS4:58 pmKnoxville McGhee Tyson
Aug 17
TYS7:20 pmKnoxville McGhee Tyson
18h 09m
2 stops
EYW1:29 pmKey West
$1,266

momondo Fare Finder

 
Customize your flight search to find flights from Key West to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Key West to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

8:00 am-2:29 pm

1 stop6h 29m

Knoxville McGhee Tyson

Mon 12/14

2:55 pm-9:45 pm

1 stop6h 50m

$319
Quickest round-trip

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

7:35 am-11:29 am

1 stop3h 54m

Knoxville McGhee Tyson

Mon 12/14

6:00 am-10:48 am

1 stop4h 48m

$319

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

4:10 pm-11:57 pm

2 stops7h 47m

Knoxville McGhee Tyson

Mon 12/14

2:55 pm-9:45 pm

1 stop6h 50m

$572

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

4:10 pm-11:57 pm

2 stops7h 47m

Knoxville McGhee Tyson

Mon 12/14

2:55 pm-9:45 pm

1 stop6h 50m

$573

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

2:30 pm-9:59 am

2 stops19h 29m

Knoxville McGhee Tyson

Mon 12/14

7:35 pm-1:02 pm

2 stops17h 27m

$769

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 12/10

2:30 pm-10:00 am

2 stops19h 30m

Knoxville McGhee Tyson

Mon 12/14

7:35 pm-1:02 pm

2 stops17h 27m

$776

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 8/14

2:15 pm-4:58 pm

2 stops26h 43m

Knoxville McGhee Tyson

Mon 8/17

7:20 pm-1:29 pm

2 stops18h 09m

$1,266
Cheapest one-way
Quickest one-way

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 11/6

10:14 am-12:27 pm

Nonstop2h 13m

$65

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Fri 11/6

10:14 am-12:27 pm

Nonstop2h 13m

$71

Key WestKnoxville

EYW - TYS

EYWTYS

Key West

Thu 8/20

3:51 pm-5:37 pm

1 stop25h 46m

$127

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 17 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Key West to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of April is, on average, the cheapest month to fly to Knoxville from Key West, with most prices found around $0. If you aren’t able to travel during the month of April, then book flights to Knoxville from Key West during February instead. Flights to Knoxville in February, while not as cheap as those in April, still average around $0.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Key West to Knoxville is on a Friday. Travelers who choose to depart for Knoxville on a Friday will often find tickets for as low as $144. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Key West to Knoxville for around $169.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Key West to Knoxville when you can find flight prices for as low as $145. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $169.

What is the cheapest Key West to Knoxville McGhee Tyson flight route?

Fly from Key West to Knoxville McGhee Tyson for the best Key West - Knoxville McGhee Tyson flight prices

What cabin class options are available on Key West to Knoxville flights?

There is only 1 cabin class available to choose from on Key West to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Key West to Knoxville flights?

No. A direct flight is the cheapest option for a flight between Key West to Knoxville.

When to book flights from Key West to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Key West to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Key West to Knoxville (EYW to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Key West to Knoxville

Fastest flight time

26h 43m

Direct flights

Sat and Sun

Airports in Knoxville

1 airport
The fastest flight from Key West to Knoxville takes 26h 43m
Direct flights go from Key West to Knoxville on Saturday and Sunday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Knoxville. From Key West there are direct flights to Knoxville McGhee Tyson (TYS).
Search flight deals

Frequently asked questions about flying from Key West to Knoxville

  • How far is Key West to Knoxville McGhee Tyson by plane?

    Key West and Knoxville McGhee Tyson are 797.5 mi apart from one another. A reasonable flight in good conditions will take 26h 43m.

  • When did momondo last update prices for flights from Key West Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Key West Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Key West Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Key West Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Key West Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The necessary travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular plane model from Key West to Knoxville?

  • What is the most popular airline from Key West to Knoxville?

Best airlines flying from Key West to Knoxville

Compare and see reviews for airlines that fly from Key West to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $92Free CancellationRating
7.3
678 reviews
Search Allegiant Air flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Key West to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Key West to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Key West to Knoxville with flexible booking policies on momondo?

Flights from Key West to Knoxville with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Key West to Knoxville?

momondo helps you find the best flight between Key West and Knoxville by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Key West to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Key West. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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