What is the cheapest airline that flies from Iowa to South Carolina?

American Airlines, Southwest, and Delta are the most popular carriers operating from Iowa to South Carolina

How long is the flight from Iowa to South Carolina?

Flight times vary depending on what airport in Iowa you fly out of and what airport in South Carolina you fly into. For example, flying from Des Moines to Charleston takes 3h 53m on average. On the other hand, flying from Cedar Rapids to Charleston takes 3h 58m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Iowa according to our data. American Airlines is the first choice among our users, with 60% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Iowa to South Carolina?

Prices for flights from Iowa to South Carolina are updated daily.

How many operators does momondo search for flights from Iowa to South Carolina?

As of November 2026, there are 4 operators available to choose from for flights from Iowa to South Carolina.

How old do you have to be to fly from Iowa to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$152 Cheap Flights from Iowa to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Iowa to South Carolina

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

2:38 pm - 9:55 pmCID Cedar Rapids-GSP Greenville

6h 17m1 stop Chicago O'Hare Intl

11:42 am - 5:48 pmGSP Greenville-CID Cedar Rapids

7h 06m1 stop Chicago O'Hare Intl

$291American Airlines

Wed, Jan 20 - Wed, Jan 27

5:10 am - 11:06 amCID Cedar Rapids-GSP Greenville

4h 56m1 stop Atlanta Hartsfield-Jackson

5:25 pm - 10:31 pmGSP Greenville-CID Cedar Rapids

6h 06m1 stop Atlanta Hartsfield-Jackson

$291Delta

Tue, Jan 19 - Tue, Jan 26

5:10 am - 11:06 amCID Cedar Rapids-GSP Greenville

4h 56m1 stop Atlanta Hartsfield-Jackson

5:25 pm - 10:31 pmGSP Greenville-CID Cedar Rapids

6h 06m1 stop Atlanta Hartsfield-Jackson

$291Delta

Wed, Jan 20 - Tue, Jan 26

8:00 am - 7:07 pmCID Cedar Rapids-GSP Greenville

10h 07m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

5:29 pm - 10:50 pmGSP Greenville-CID Cedar Rapids

6h 21m1 stop Chicago O'Hare Intl

$296United Airlines

Wed, Jan 20 - Wed, Jan 27

8:00 am - 7:07 pmCID Cedar Rapids-GSP Greenville

10h 07m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

2:57 pm - 9:31 pmGSP Greenville-CID Cedar Rapids

7h 34m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$301United Airlines

Wed, Jan 20 - Wed, Jan 27

6:00 am - 1:05 pmCID Cedar Rapids-MYR Myrtle Beach Intl

6h 05m1 stop Charlotte Douglas

5:06 pm - 8:49 pmMYR Myrtle Beach Intl-CID Cedar Rapids

4h 43m1 stop Charlotte Douglas

$311American Airlines

Wed, Jan 6 - Tue, Jan 12

6:29 pm - 8:38 amCID Cedar Rapids-CHS Charleston

13h 09m1 stop Orlando Sanford Intl

10:15 pm - 4:56 pmCHS Charleston-CID Cedar Rapids

19h 41m1 stop Fort Lauderdale

$331Multiple Airlines

Fri, Dec 4 - Sun, Dec 6

6:00 am - 5:25 pmDSM Des Moines-CHS Charleston

10h 25m2 stops Chicago Midway Nashville Intl

6:40 am - 10:10 amCHS Charleston-DSM Des Moines

4h 30m1 stop Nashville Intl

$336Southwest

Thu, Dec 24 - Thu, Jan 14

6:00 am - 5:25 pmDSM Des Moines-CHS Charleston

10h 25m2 stops Chicago Midway Nashville Intl

1:35 pm - 9:30 pmCHS Charleston-DSM Des Moines

8h 55m2 stops Baltimore/Washington Chicago Midway

$341Southwest

Thu, Dec 24 - Thu, Jan 14

5:46 pm - 2:05 pmCID Cedar Rapids-CHS Charleston

19h 19m2 stops Fort Lauderdale Tampa

10:15 pm - 4:56 pmCHS Charleston-CID Cedar Rapids

19h 41m1 stop Fort Lauderdale

$409Multiple Airlines

Fri, Dec 4 - Sun, Dec 6

Cheap last minute flights

Enter your travel dates to find the best prices.

5:15 am - 10:07 amCID Cedar Rapids-MYR Myrtle Beach Intl

3h 52m1 stop Atlanta Hartsfield-Jackson

6:58 pm - 11:09 pmMYR Myrtle Beach Intl-CID Cedar Rapids

5h 11m1 stop Atlanta Hartsfield-Jackson

$425Delta

Mon, Nov 9 - Wed, Nov 18

5:15 am - 10:07 amCID Cedar Rapids-MYR Myrtle Beach Intl

3h 52m1 stop Atlanta Hartsfield-Jackson

6:58 pm - 11:09 pmMYR Myrtle Beach Intl-CID Cedar Rapids

5h 11m1 stop Atlanta Hartsfield-Jackson

$425Delta

Mon, Nov 9 - Tue, Nov 17

1:40 pm - 7:55 pmCID Cedar Rapids-MYR Myrtle Beach Intl

5h 15m1 stop Charlotte Douglas

10:17 am - 2:17 pmMYR Myrtle Beach Intl-CID Cedar Rapids

5h 00m1 stop Charlotte Douglas

$429American Airlines

Fri, Nov 6 - Tue, Nov 10

1:40 pm - 7:55 pmCID Cedar Rapids-MYR Myrtle Beach Intl

5h 15m1 stop Charlotte Douglas

10:17 am - 5:39 pmMYR Myrtle Beach Intl-CID Cedar Rapids

8h 22m2 stops Charlotte Douglas Chicago O'Hare Intl

$438American Airlines

Fri, Nov 6 - Tue, Nov 10

6:00 am - 7:01 pmCID Cedar Rapids-GSP Greenville

12h 01m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

5:37 pm - 10:56 pmGSP Greenville-CID Cedar Rapids

6h 19m1 stop Chicago O'Hare Intl

$449United Airlines

Thu, Nov 5 - Mon, Nov 9

8:04 pm - 10:10 pmDSM Des Moines-CHS Charleston

25h 06m2 stops Las Vegas Harry Reid Intl Akron/Canton

7:54 pm - 4:11 pmCHS Charleston-DSM Des Moines

21h 17m1 stop Fort Lauderdale

$461Multiple Airlines

Mon, Nov 9 - Wed, Nov 18

6:00 am - 2:16 pmCID Cedar Rapids-GSP Greenville

7h 16m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

2:51 pm - 10:56 pmGSP Greenville-CID Cedar Rapids

9h 05m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$463United Airlines

Thu, Nov 5 - Mon, Nov 9

8:04 pm - 10:10 pmDSM Des Moines-CHS Charleston

25h 06m2 stops Las Vegas Harry Reid Intl Akron/Canton

3:14 pm - 10:15 pmCHS Charleston-DSM Des Moines

8h 01m1 stop Fort Myers SW Florida Intl

$468Multiple Airlines

Mon, Nov 9 - Fri, Nov 13

7:00 am - 6:10 pmDSM Des Moines-GSP Greenville

10h 10m2 stops Denver Intl Nashville Intl

12:50 pm - 7:45 pmGSP Greenville-DSM Des Moines

7h 55m2 stops Baltimore/Washington Chicago Midway

$742Southwest

Wed, Nov 4 - Sat, Nov 7

4:25 pm - 11:00 pmDSM Des Moines-GSP Greenville

5h 35m2 stops Chicago Midway Nashville Intl

10:45 am - 10:05 pmGSP Greenville-DSM Des Moines

12h 20m2 stops Nashville Intl Denver Intl

$742Southwest

Fri, Nov 6 - Mon, Nov 9

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Southwest flights from Iowa to South Carolina

Our best Southwest deals on Iowa to South Carolina flight tickets

Southwest

Dec 24

DSM6:00 amDes Moines

10h 25m

2 stops

CHS5:25 pmCharleston

Jan 14

CHS6:40 amCharleston

4h 30m

1 stop

DSM10:10 amDes Moines

$336

Southwest

Dec 24

DSM6:00 amDes Moines

10h 25m

2 stops

CHS5:25 pmCharleston

Jan 14

CHS1:35 pmCharleston

8h 55m

2 stops

DSM9:30 pmDes Moines

$341

Southwest

Dec 5

DSM5:20 amDes Moines

5h 55m

2 stops

GSP12:15 pmGreenville

Dec 7

GSP2:50 pmGreenville

8h 15m

2 stops

DSM10:05 pmDes Moines

$379

Delta flights from Iowa to South Carolina

Our best Delta deals on Iowa to South Carolina flight tickets

Delta

Jan 19

CID5:10 amCedar Rapids

4h 56m

1 stop

GSP11:06 amGreenville

Jan 26

GSP5:25 pmGreenville

6h 06m

1 stop

CID10:31 pmCedar Rapids

$291

Delta

Jan 19

CID5:10 amCedar Rapids

4h 56m

1 stop

GSP11:06 amGreenville

Jan 30

GSP7:13 amGreenville

10h 38m

2 stops

CID4:51 pmCedar Rapids

$296

Delta

Jan 19

CID10:54 amCedar Rapids

8h 49m

2 stops

GSP8:43 pmGreenville

Jan 27

GSP8:01 amGreenville

9h 50m

2 stops

CID4:51 pmCedar Rapids

$301

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Cedar RapidsGreenville

CID Cedar Rapids - GSP Greenville

CIDGSP

Cedar Rapids

Wed 1/20

2:38 pm-9:55 pm

1 stop6h 17m

Greenville

Wed 1/27

11:42 am-5:48 pm

1 stop7h 06m

$291

Cedar RapidsGreenville

CID Cedar Rapids - GSP Greenville

CIDGSP

Cedar Rapids

Tue 1/19

5:10 am-11:06 am

1 stop4h 56m

Greenville

Tue 1/26

5:25 pm-10:31 pm

1 stop6h 06m

$291

Cedar RapidsGreenville

CID Cedar Rapids - GSP Greenville

CIDGSP

Cedar Rapids

Wed 1/20

5:10 am-11:06 am

1 stop4h 56m

Greenville

Tue 1/26

5:25 pm-10:31 pm

1 stop6h 06m

$291

Cedar RapidsGreenville

CID Cedar Rapids - GSP Greenville

CIDGSP

Cedar Rapids

Wed 1/20

8:00 am-7:07 pm

2 stops10h 07m

Greenville

Wed 1/27

5:29 pm-10:50 pm

1 stop6h 21m

$296

Cedar RapidsGreenville

CID Cedar Rapids - GSP Greenville

CIDGSP

Cedar Rapids

Wed 1/20

8:00 am-7:07 pm

2 stops10h 07m

Greenville

Wed 1/27

2:57 pm-9:31 pm

2 stops7h 34m

$301

Quickest round-trip

Cedar RapidsMyrtle Beach

CID Cedar Rapids - MYR Myrtle Beach Intl

CIDMYR

Cedar Rapids

Wed 1/6

6:00 am-1:05 pm

1 stop6h 05m

Myrtle Beach Intl

Tue 1/12

5:06 pm-8:49 pm

1 stop4h 43m

$311

Cedar RapidsCharleston

CID Cedar Rapids - CHS Charleston

CIDCHS

Cedar Rapids

Fri 12/4

6:29 pm-8:38 am

1 stop13h 09m

Charleston

Sun 12/6

10:15 pm-4:56 pm

1 stop19h 41m

$331

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Thu 12/24

6:00 am-5:25 pm

2 stops10h 25m

Charleston

Thu 1/14

6:40 am-10:10 am

1 stop4h 30m

$336

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Thu 12/24

6:00 am-5:25 pm

2 stops10h 25m

Charleston

Thu 1/14

1:35 pm-9:30 pm

2 stops8h 55m

$341

Cedar RapidsCharleston

CID Cedar Rapids - CHS Charleston

CIDCHS

Cedar Rapids

Fri 12/4

5:46 pm-2:05 pm

2 stops19h 19m

Charleston

Sun 12/6

10:15 pm-4:56 pm

1 stop19h 41m

$409

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Iowa to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Iowa is in February. Flight prices, which tend to average around $330, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to South Carolina from Iowa during August instead. Flights to South Carolina in August, while not as cheap as those in February, still average around $365.

Can stopping save me money on Iowa to South Carolina flights?

You could potentially save up to 27% on your flight if you consider stops on a Iowa to South Carolina flight.

Cheap Iowa to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to South Carolina

Best Price Found	$152
Fastest flight time	2h 13m
Direct flights	None

The best one-way flight to South Carolina from Iowa in the past 72 hours is $152. The best round-trip flight deal from Iowa to South Carolina found on momondo in the last 72 hours is $291.

The fastest flight from Iowa to South Carolina takes 2h 13m

There are no direct flights from Iowa to South Carolina. There are no popular flight routes from Iowa to South Carolina.

Search flight deals

Frequently asked questions about flying from Iowa to South Carolina

When did momondo last update prices for flights from Iowa to South Carolina?
Prices for flights from Iowa to South Carolina are updated daily.
How many operators does momondo search for flights from Iowa to South Carolina?
As of November 2026, there are 4 operators available to choose from for flights from Iowa to South Carolina.
How old do you have to be to fly from Iowa to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Iowa to South Carolina

Compare and see reviews for airlines that fly from Iowa to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.3 10,460 reviews	Search United Airlines flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.0 12,224 reviews	Search American Airlines flights
Delta	PriceFrom $260	Free Cancellation	Rating 7.8 8,700 reviews	Search Delta flights
Southwest	PriceFrom $344	Free Cancellation	Rating 8.0 4,219 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Iowa to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Iowa to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Iowa to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Iowa to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Iowa.

I’m not ready to book a flight from Iowa to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Iowa to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.