What is the cheapest airline that flies from Iowa to South Carolina?

Frontier, American Airlines, and Delta are the most popular carriers operating from Iowa to South Carolina

How many flights depart from Iowa to South Carolina on average per week?

41 flights are operational weekly from Iowa to South Carolina as of August 2025. The most popular departure day for this route is Thu, with 20% of flights per week taking off on this day.

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Iowa according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How long is the flight from Iowa to South Carolina?

Flight times vary depending on what airport in Iowa you fly out of and what airport in South Carolina you fly into. For example, flying from Des Moines to Charleston takes 4h 11m on average. On the other hand, flying from Cedar Rapids to Charleston takes 4h 39m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

When did momondo last update prices for flights from Iowa to South Carolina?

Prices for flights from Iowa to South Carolina are updated daily.

How many operators does momondo search for flights from Iowa to South Carolina?

As of August 2025, there are 4 operators available to choose from for flights from Iowa to South Carolina.

How old do you have to be to fly from Iowa to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$107 Cheap Flights from Iowa to South Carolina in 2025

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Find the cheapest flights from Iowa to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

11:10 am - 1:22 pmOMA-CLT

25h 12m1 stop

7:03 pm - 10:16 amCLT-OMA

16h 13m1 stop

$215Frontier

Find Deal

Thu, Aug 14 - Sat, Aug 16

1:58 pm - 5:30 pmOMA-CLT

2h 32mnonstop

9:57 pm - 11:39 pmCLT-OMA

2h 42mnonstop

$217American Airlines

Find Deal

Sat, Oct 18 - Wed, Oct 22

2:22 pm - 9:22 amDSM-CLT

18h 00m2 stops

9:10 am - 2:40 pmCLT-DSM

6h 30m1 stop

$224

Find Deal

Mon, Sep 8 - Fri, Sep 12

6:00 am - 12:02 pmDSM-CLT

5h 02m1 stop

6:20 am - 10:14 amCLT-DSM

4h 54m1 stop

$227Delta

Find Deal

Sat, Sep 13 - Tue, Sep 16

5:15 am - 1:02 pmOMA-CLT

6h 47m1 stop

7:45 pm - 11:59 pmCLT-OMA

5h 14m1 stop

$227Delta

Find Deal

Wed, Oct 1 - Mon, Oct 6

8:00 am - 9:37 pmDSM-CLT

12h 37m1 stop

9:10 am - 2:40 pmCLT-DSM

6h 30m1 stop

$228

Find Deal

Mon, Sep 8 - Fri, Sep 12

4:45 pm - 9:30 pmDSM-CLT

3h 45m1 stop

6:25 pm - 11:35 pmCLT-DSM

6h 10m1 stop

$236Southwest

Find Deal

Tue, Oct 21 - Thu, Nov 6

8:00 am - 2:44 pmCID-SAV

5h 44m1 stop

4:45 pm - 9:30 pmSAV-CID

5h 45m1 stop

$249United Airlines

Find Deal

Thu, Sep 4 - Mon, Sep 8

7:25 am - 8:45 pmDSM-CLT

12h 20m1 stop

8:05 am - 9:50 pmCLT-DSM

14h 45m2 stops

$253Southwest

Find Deal

Sat, Oct 4 - Wed, Oct 8

8:00 am - 1:56 pmCID-CHS

4h 56m1 stop

8:23 pm - 1:10 amCHS-CID

5h 47m1 stop

$266United Airlines

Find Deal

Thu, Nov 27 - Sun, Nov 30

Southwest flights from Iowa to South Carolina

Our best Southwest deals on Iowa to South Carolina flight tickets

Southwest

Oct 21

DSM4:45 pmDes Moines

3h 45m

1 stop

CLT9:30 pmCharlotte Douglas

Nov 6

CLT6:25 pmCharlotte Douglas

6h 10m

1 stop

DSM11:35 pmDes Moines

$236

Find similar

Southwest

Oct 4

DSM7:25 amDes Moines

12h 20m

1 stop

CLT8:45 pmCharlotte Douglas

Oct 8

CLT8:05 amCharlotte Douglas

14h 45m

2 stops

DSM9:50 pmDes Moines

$253

Find similar

Southwest

Sep 19

OMA4:20 pmOmaha Eppley Airfield

4h 20m

1 stop

CLT9:40 pmCharlotte Douglas

Sep 24

CLT6:30 amCharlotte Douglas

4h 30m

1 stop

OMA10:00 amOmaha Eppley Airfield

$258

Find similar

Frontier flights from Iowa to South Carolina

Our best Frontier deals on Iowa to South Carolina flight tickets

Frontier

Aug 14

OMA11:10 amOmaha Eppley Airfield

25h 12m

1 stop

CLT1:22 pmCharlotte Douglas

Aug 16

CLT7:03 pmCharlotte Douglas

16h 13m

1 stop

OMA10:16 amOmaha Eppley Airfield

$215

Find similar

Frontier

Sep 25

OMA7:48 pmOmaha Eppley Airfield

19h 55m

1 stop

CLT4:43 pmCharlotte Douglas

Sep 28

CLT5:20 pmCharlotte Douglas

21h 01m

1 stop

OMA1:21 pmOmaha Eppley Airfield

$225

Find similar

Frontier

Oct 22

DSM3:30 pmDes Moines

24h 02m

1 stop

CLT4:32 pmCharlotte Douglas

Nov 6

CLT5:34 pmCharlotte Douglas

27h 25m

1 stop

DSM7:59 pmDes Moines

$235

Find similar

Fly from

Fly to

Route

Depart

Return

Price

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Thu 8/14

11:10 am-1:22 pm

1 stop25h 12m

Charlotte Douglas

Sat 8/16

7:03 pm-10:16 am

1 stop16h 13m

$215

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Sat 10/18

1:58 pm-5:30 pm

Nonstop2h 32m

Charlotte Douglas

Wed 10/22

9:57 pm-11:39 pm

Nonstop2h 42m

$217

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 9/8

2:22 pm-9:22 am

2 stops18h 00m

Charlotte Douglas

Fri 9/12

9:10 am-2:40 pm

1 stop6h 30m

$224

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 9/13

6:00 am-12:02 pm

1 stop5h 02m

Charlotte Douglas

Tue 9/16

6:20 am-10:14 am

1 stop4h 54m

$227

OmahaCharlotte

OMA - CLT

OMACLT

Omaha Eppley Airfield

Wed 10/1

5:15 am-1:02 pm

1 stop6h 47m

Charlotte Douglas

Mon 10/6

7:45 pm-11:59 pm

1 stop5h 14m

$227

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 9/8

8:00 am-9:37 pm

1 stop12h 37m

Charlotte Douglas

Fri 9/12

9:10 am-2:40 pm

1 stop6h 30m

$228

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Tue 10/21

4:45 pm-9:30 pm

1 stop3h 45m

Charlotte Douglas

Thu 11/6

6:25 pm-11:35 pm

1 stop6h 10m

$236

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Thu 9/4

8:00 am-2:44 pm

1 stop5h 44m

Savannah/Hilton Head

Mon 9/8

4:45 pm-9:30 pm

1 stop5h 45m

$249

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sat 10/4

7:25 am-8:45 pm

1 stop12h 20m

Charlotte Douglas

Wed 10/8

8:05 am-9:50 pm

2 stops14h 45m

$253

Cedar RapidsCharleston

CID - CHS

CIDCHS

Cedar Rapids

Thu 11/27

8:00 am-1:56 pm

1 stop4h 56m

Charleston

Sun 11/30

8:23 pm-1:10 am

1 stop5h 47m

$266

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Iowa to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Iowa is in September. Flight prices, which tend to average around $334, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Iowa during August instead. Flights to South Carolina in August, while not as cheap as those in September, still average around $340.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $379. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Iowa to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $386. Try not to purchase tickets in the morning because they tend to be around $405. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Iowa when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $388 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Iowa for as low as $321 on momondo.

Can stopping save me money on Iowa to South Carolina flights?

You could potentially save up to 49% on your flight if you consider stops on a Iowa to South Carolina flight.

Cheap Iowa to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to South Carolina

Best Price Found	$107
Fastest flight time	2h 06m
Direct flights	Mon, Wed, Thu, Fri, Sat and Sun
Airports in South Carolina	4 airports

The best one-way flight to South Carolina from Iowa in the past 72 hours is $107. The best round-trip flight deal from Iowa to South Carolina found on momondo in the last 72 hours is $215.

The fastest flight from Iowa to South Carolina takes 2h 06m

Direct flights go from Iowa to South Carolina on Monday, Wednesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is American Airlines.

There are 4 airports near South Carolina: Myrtle Beach Intl (MYR), Savannah/Hilton Head (SAV), Charlotte Douglas (CLT), Charleston (CHS)

Search flight deals

When did momondo last update prices for flights from Iowa to South Carolina?
Prices for flights from Iowa to South Carolina are updated daily.
How many operators does momondo search for flights from Iowa to South Carolina?
As of August 2025, there are 4 operators available to choose from for flights from Iowa to South Carolina.
How old do you have to be to fly from Iowa to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Iowa to South Carolina

Compare and see reviews for airlines that fly from Iowa to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $228	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
Delta	PriceFrom $232	Free Cancellation	Rating 8.0 7,981 reviews	Search Delta flights
United Airlines	PriceFrom $235	Free Cancellation	Rating 7.4 8,900 reviews	Search United Airlines flights
Southwest	PriceFrom $272	Free Cancellation	Rating 8.0 4,246 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Iowa to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Iowa to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Iowa to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Iowa to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Iowa.

I’m not ready to book a flight from Iowa to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Iowa to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.