What is the cheapest airline that flies from Iowa to South Carolina?

Frontier, American Airlines, and Delta are the most popular carriers operating from Iowa to South Carolina

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Iowa according to our data. American Airlines is the first choice among our users, with 69% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How many flights depart from Iowa to South Carolina on average per week?

23 flights are operational weekly from Iowa to South Carolina as of December 2025. The most popular departure day for this route is Tue, with 35% of flights per week taking off on this day.

How long is the flight from Iowa to South Carolina?

Flight times vary depending on what airport in Iowa you fly out of and what airport in South Carolina you fly into. For example, flying from Des Moines to Charleston takes 4h 21m on average. On the other hand, flying from Cedar Rapids to Charleston takes 4h 45m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

When did momondo last update prices for flights from Iowa to South Carolina?

Prices for flights from Iowa to South Carolina are updated daily.

How many operators does momondo search for flights from Iowa to South Carolina?

As of December 2025, there are 4 operators available to choose from for flights from Iowa to South Carolina.

How old do you have to be to fly from Iowa to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$81 Cheap Flights from Iowa to South Carolina in 2025/26

1 adult

0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Iowa to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:11 pm - 11:55 pm

MLI

CHS

5h 44m1 stop

5:18 pm - 10:33 pm

CHS

MLI

6h 15m1 stop

$243Delta

Fri, Jan 16 - Sun, Jan 18

2:58 pm - 12:40 am

DSM

CLT

8h 42m1 stop

1:24 pm - 10:46 pm

CLT

DSM

10h 22m1 stop

$244Multiple Airlines

Thu, Jan 29 - Thu, Feb 5

2:58 pm - 5:36 pm

DSM

CHS

25h 38m1 stop

11:10 am - 7:23 pm

CHS

DSM

33h 13m2 stops

$246Multiple Airlines

Sun, Jan 11 - Sun, Jan 18

7:43 am - 4:58 pm

DSM

CAE

8h 15m1 stop

6:00 am - 12:46 pm

CAE

DSM

7h 46m1 stop

$270American Airlines

Fri, Jan 30 - Fri, Feb 6

1:26 pm - 11:59 pm

CID

SAV

9h 33m2 stops

6:15 am - 2:42 pm

SAV

CID

9h 27m2 stops

$279American Airlines

Thu, Jan 8 - Thu, Jan 22

6:30 am - 2:09 pm

MLI

CHS

6h 39m1 stop

2:58 pm - 9:36 pm

CHS

MLI

7h 38m2 stops

$279United Airlines

Fri, Jan 2 - Fri, Jan 9

8:00 am - 2:38 pm

CID

SAV

5h 38m1 stop

4:46 pm - 9:34 pm

SAV

CID

5h 48m1 stop

$287United Airlines

Sat, Jan 24 - Wed, Jan 28

5:50 am - 3:20 pm

OMA

SAV

8h 30m2 stops

6:30 am - 10:00 am

SAV

OMA

4h 30m1 stop

$338Southwest

Wed, Feb 11 - Tue, Feb 17

6:55 am - 7:10 pm

OMA

CHS

11h 15m2 stops

6:55 am - 4:25 pm

CHS

OMA

10h 30m2 stops

$354Southwest

Mon, Jan 26 - Wed, Jan 28

4:13 pm - 6:48 pm

CID

CLT

25h 35m1 stop

7:43 pm - 3:27 pm

CLT

CID

20h 44m1 stop

$471Frontier

Thu, Mar 12 - Sun, Mar 15

American Airlines flights from Iowa to South Carolina

Our best American Airlines deals on Iowa to South Carolina flight tickets

American Airlines

Jan 30

DSM7:43 amDes Moines

8h 15m

1 stop

CAE4:58 pmColumbia Metropolitan

Feb 6

CAE6:00 amColumbia Metropolitan

7h 46m

1 stop

DSM12:46 pmDes Moines

$270

Find similar

American Airlines

Jan 8

CID1:26 pmCedar Rapids

9h 33m

2 stops

SAV11:59 pmSavannah/Hilton Head

Jan 22

SAV6:15 amSavannah/Hilton Head

9h 27m

2 stops

CID2:42 pmCedar Rapids

$279

Find similar

American Airlines

Jan 28

DSM7:43 amDes Moines

8h 24m

2 stops

CAE5:07 pmColumbia Metropolitan

Feb 4

CAE6:18 amColumbia Metropolitan

7h 28m

2 stops

DSM12:46 pmDes Moines

$280

Find similar

United Airlines flights from Iowa to South Carolina

Our best United Airlines deals on Iowa to South Carolina flight tickets

United Airlines

Jan 2

MLI6:30 amMoline Quad-City

6h 39m

1 stop

CHS2:09 pmCharleston

Jan 9

CHS2:58 pmCharleston

7h 38m

2 stops

MLI9:36 pmMoline Quad-City

$279

Find similar

United Airlines

Jan 24

CID8:00 amCedar Rapids

5h 38m

1 stop

SAV2:38 pmSavannah/Hilton Head

Jan 28

SAV4:46 pmSavannah/Hilton Head

5h 48m

1 stop

CID9:34 pmCedar Rapids

$287

Find similar

United Airlines

Jan 24

CID3:10 pmCedar Rapids

5h 26m

1 stop

SAV9:36 pmSavannah/Hilton Head

Jan 28

SAV6:40 amSavannah/Hilton Head

8h 40m

2 stops

CID2:20 pmCedar Rapids

$292

Find similar

Fly from

Fly to

Route

Depart

Return

Price

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/16

5:11 pm-11:55 pm

1 stop5h 44m

Charleston

Sun 1/18

5:18 pm-10:33 pm

1 stop6h 15m

$243

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Thu 1/29

2:58 pm-12:40 am

1 stop8h 42m

Charlotte Douglas

Thu 2/5

1:24 pm-10:46 pm

1 stop10h 22m

$244

Des MoinesCharleston

DSM - CHS

DSMCHS

Des Moines

Sun 1/11

2:58 pm-5:36 pm

1 stop25h 38m

Charleston

Sun 1/18

11:10 am-7:23 pm

2 stops33h 13m

$246

Des MoinesColumbia

DSM - CAE

DSMCAE

Des Moines

Fri 1/30

7:43 am-4:58 pm

1 stop8h 15m

Columbia Metropolitan

Fri 2/6

6:00 am-12:46 pm

1 stop7h 46m

$270

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Thu 1/8

1:26 pm-11:59 pm

2 stops9h 33m

Savannah/Hilton Head

Thu 1/22

6:15 am-2:42 pm

2 stops9h 27m

$279

MolineCharleston

MLI - CHS

MLICHS

Moline Quad-City

Fri 1/2

6:30 am-2:09 pm

1 stop6h 39m

Charleston

Fri 1/9

2:58 pm-9:36 pm

2 stops7h 38m

$279

Cedar RapidsSavannah

CID - SAV

CIDSAV

Cedar Rapids

Sat 1/24

8:00 am-2:38 pm

1 stop5h 38m

Savannah/Hilton Head

Wed 1/28

4:46 pm-9:34 pm

1 stop5h 48m

$287

OmahaSavannah

OMA - SAV

OMASAV

Omaha Eppley Airfield

Wed 2/11

5:50 am-3:20 pm

2 stops8h 30m

Savannah/Hilton Head

Tue 2/17

6:30 am-10:00 am

1 stop4h 30m

$338

OmahaCharleston

OMA - CHS

OMACHS

Omaha Eppley Airfield

Mon 1/26

6:55 am-7:10 pm

2 stops11h 15m

Charleston

Wed 1/28

6:55 am-4:25 pm

2 stops10h 30m

$354

Cedar RapidsCharlotte

CID - CLT

CIDCLT

Cedar Rapids

Thu 3/12

4:13 pm-6:48 pm

1 stop25h 35m

Charlotte Douglas

Sun 3/15

7:43 pm-3:27 pm

1 stop20h 44m

$471

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Iowa to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Iowa is in September. Flight prices, which tend to average around $285, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Iowa during January instead. Flights to South Carolina in January, while not as cheap as those in September, still average around $324.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $379. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Iowa to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $386. Try not to purchase tickets in the morning because they tend to be around $405. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Iowa when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $387 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Iowa for as low as $242 on momondo.

Can stopping save me money on Iowa to South Carolina flights?

You could potentially save up to 35% on your flight if you consider stops on a Iowa to South Carolina flight.

Cheap Iowa to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to South Carolina

Fastest flight time	2h 11m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Iowa to South Carolina takes 2h 11m

Direct flights go from Iowa to South Carolina every day.

There are 57 airports in South Carolina. From Iowa there are direct flights to Charlotte Douglas (CLT).

Search flight deals

When did momondo last update prices for flights from Iowa to South Carolina?
Prices for flights from Iowa to South Carolina are updated daily.
How many operators does momondo search for flights from Iowa to South Carolina?
As of December 2025, there are 4 operators available to choose from for flights from Iowa to South Carolina.
How old do you have to be to fly from Iowa to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Iowa to South Carolina

Compare and see reviews for airlines that fly from Iowa to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $199	Free Cancellation	Rating 7.9 8,008 reviews	Search Delta flights
American Airlines	PriceFrom $229	Free Cancellation	Rating 7.2 11,049 reviews	Search American Airlines flights
United Airlines	PriceFrom $235	Free Cancellation	Rating 7.4 9,092 reviews	Search United Airlines flights
Southwest	PriceFrom $272	Free Cancellation	Rating 7.9 4,250 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Iowa to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Iowa to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Iowa to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Iowa to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Iowa.

I’m not ready to book a flight from Iowa to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Iowa to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.