What is the cheapest airline that flies from Iowa to South Carolina?

Delta, American Airlines, and Southwest are the most popular carriers operating from Iowa to South Carolina

How long is the flight from Iowa to South Carolina?

Flight times vary depending on what airport in Iowa you fly out of and what airport in South Carolina you fly into. For example, flying from Des Moines to Charleston takes 4h 35m on average. On the other hand, flying from Cedar Rapids to Charleston takes 4h 43m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

How many flights depart from Iowa to South Carolina on average per week?

34 flights are operational weekly from Iowa to South Carolina as of June 2026. The most popular departure day for this route is Mon, with 18% of flights per week taking off on this day.

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Iowa according to our data. American Airlines is the first choice among our users, with 66% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Iowa to South Carolina?

Prices for flights from Iowa to South Carolina are updated daily.

How many operators does momondo search for flights from Iowa to South Carolina?

As of June 2026, there are 4 operators available to choose from for flights from Iowa to South Carolina.

How old do you have to be to fly from Iowa to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$107 Cheap Flights from Iowa to South Carolina in 2026

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Find the cheapest flights from Iowa to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:40 am - 1:33 pm

DSM

MYR

6h 53m

1 stop

11:33 am - 5:11 pm

MYR

DSM

6h 38m

1 stop

$231Delta

Tue, Aug 18 - Wed, Aug 19

5:25 pm - 11:30 pm

OMA

MYR

5h 05m

1 stop

12:50 pm - 5:04 pm

MYR

OMA

5h 14m

1 stop

$237Delta

Tue, Sep 22 - Tue, Sep 29

5:55 pm - 9:07 pm

CID

CLT

26h 12m

1 stop

6:41 pm - 5:05 pm

CLT

CID

23h 24m

1 stop

$239Multiple Airlines

Mon, Jul 13 - Thu, Jul 16

6:30 am - 2:19 pm

CID

MYR

6h 49m

1 stop

3:15 pm - 8:58 pm

MYR

CID

6h 43m

1 stop

$268United Airlines

Tue, Jun 30 - Tue, Jul 7

4:40 pm - 9:07 pm

DSM

CLT

27h 27m

1 stop

6:41 pm - 11:19 pm

CLT

DSM

29h 38m

2 stops

$275Multiple Airlines

Mon, Aug 3 - Wed, Aug 12

5:04 am - 11:34 am

CID

MYR

5h 30m

1 stop

4:23 pm - 11:25 pm

MYR

CID

8h 02m

1 stop

$285American Airlines

Mon, Aug 10 - Sat, Aug 15

3:13 pm - 9:04 pm

OMA

CHS

4h 51m

1 stop

6:00 am - 12:14 pm

CHS

OMA

7h 14m

2 stops

$299United Airlines

Sat, Sep 26 - Wed, Sep 30

5:04 am - 11:34 am

CID

MYR

5h 30m

1 stop

4:23 pm - 11:30 pm

MYR

CID

8h 07m

1 stop

$304American Airlines

Sat, Aug 15 - Wed, Aug 19

10:30 am - 7:20 pm

OMA

MYR

7h 50m

2 stops

8:15 am - 4:05 pm

MYR

OMA

8h 50m

2 stops

$337Southwest

Tue, Sep 22 - Tue, Sep 29

10:30 am - 7:10 pm

OMA

MYR

7h 40m

2 stops

7:50 am - 4:05 pm

MYR

OMA

9h 15m

1 stop

$338Southwest

Tue, Sep 22 - Tue, Sep 29

Frontier flights from Iowa to South Carolina

Our best Frontier deals on Iowa to South Carolina flight tickets

Frontier

Jul 1

OMA8:15 pmOmaha Eppley Airfield

21h 04m

1 stop

CLT6:19 pmCharlotte Douglas

Jul 8

CLT10:04 pmCharlotte Douglas

22h 11m

1 stop

OMA7:15 pmOmaha Eppley Airfield

$242

Frontier

Jun 25

OMA8:15 pmOmaha Eppley Airfield

24h 10m

1 stop

CLT9:25 pmCharlotte Douglas

Jun 30

CLT7:14 pmCharlotte Douglas

25h 16m

1 stop

OMA7:30 pmOmaha Eppley Airfield

$259

Frontier

Jul 1

OMA8:15 pmOmaha Eppley Airfield

21h 04m

1 stop

CLT6:19 pmCharlotte Douglas

Jul 6

CLT10:04 pmCharlotte Douglas

22h 11m

1 stop

OMA7:15 pmOmaha Eppley Airfield

$261

American Airlines flights from Iowa to South Carolina

Our best American Airlines deals on Iowa to South Carolina flight tickets

American Airlines

Aug 10

CID5:04 amCedar Rapids

5h 30m

1 stop

MYR11:34 amMyrtle Beach Intl

Aug 15

MYR4:23 pmMyrtle Beach Intl

8h 02m

1 stop

CID11:25 pmCedar Rapids

$285

American Airlines

Aug 15

CID5:04 amCedar Rapids

5h 30m

1 stop

MYR11:34 amMyrtle Beach Intl

Aug 19

MYR4:23 pmMyrtle Beach Intl

8h 07m

1 stop

CID11:30 pmCedar Rapids

$304

American Airlines

Aug 18

DSM6:33 amDes Moines

8h 04m

1 stop

MYR3:37 pmMyrtle Beach Intl

Aug 19

MYR12:14 pmMyrtle Beach Intl

8h 05m

2 stops

DSM7:19 pmDes Moines

$324

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 8/18

5:40 am-1:33 pm

1 stop6h 53m

Myrtle Beach Intl

Wed 8/19

11:33 am-5:11 pm

1 stop6h 38m

$231

Quickest round-trip

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Tue 9/22

5:25 pm-11:30 pm

1 stop5h 05m

Myrtle Beach Intl

Tue 9/29

12:50 pm-5:04 pm

1 stop5h 14m

$237

Cedar RapidsCharlotte

CID - CLT

CIDCLT

Cedar Rapids

Mon 7/13

5:55 pm-9:07 pm

1 stop26h 12m

Charlotte Douglas

Thu 7/16

6:41 pm-5:05 pm

1 stop23h 24m

$239

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Tue 6/30

6:30 am-2:19 pm

1 stop6h 49m

Myrtle Beach Intl

Tue 7/7

3:15 pm-8:58 pm

1 stop6h 43m

$268

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Mon 8/3

4:40 pm-9:07 pm

1 stop27h 27m

Charlotte Douglas

Wed 8/12

6:41 pm-11:19 pm

2 stops29h 38m

$275

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Mon 8/10

5:04 am-11:34 am

1 stop5h 30m

Myrtle Beach Intl

Sat 8/15

4:23 pm-11:25 pm

1 stop8h 02m

$285

OmahaCharleston

OMA - CHS

OMACHS

Omaha Eppley Airfield

Sat 9/26

3:13 pm-9:04 pm

1 stop4h 51m

Charleston

Wed 9/30

6:00 am-12:14 pm

2 stops7h 14m

$299

Cedar RapidsMyrtle Beach

CID - MYR

CIDMYR

Cedar Rapids

Sat 8/15

5:04 am-11:34 am

1 stop5h 30m

Myrtle Beach Intl

Wed 8/19

4:23 pm-11:30 pm

1 stop8h 07m

$304

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Tue 9/22

10:30 am-7:20 pm

2 stops7h 50m

Myrtle Beach Intl

Tue 9/29

8:15 am-4:05 pm

2 stops8h 50m

$337

OmahaMyrtle Beach

OMA - MYR

OMAMYR

Omaha Eppley Airfield

Tue 9/22

10:30 am-7:10 pm

2 stops7h 40m

Myrtle Beach Intl

Tue 9/29

7:50 am-4:05 pm

1 stop9h 15m

$338

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Iowa to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Iowa is in November. Flight prices, which tend to average around $118, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of November, then book flights to South Carolina from Iowa during June instead. Flights to South Carolina in June, while not as cheap as those in November, still average around $134.

Can stopping save me money on Iowa to South Carolina flights?

You could potentially save up to 17% on your flight if you consider stops on a Iowa to South Carolina flight.

Cheap Iowa to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to South Carolina

Fastest flight time	2h 15m
Direct flights	Every day
Airports in South Carolina	57 airports

The fastest flight from Iowa to South Carolina takes 2h 15m

Direct flights go from Iowa to South Carolina every day.

There are 57 airports in South Carolina. From Iowa there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Iowa to South Carolina

When did momondo last update prices for flights from Iowa to South Carolina?
Prices for flights from Iowa to South Carolina are updated daily.
How many operators does momondo search for flights from Iowa to South Carolina?
As of June 2026, there are 4 operators available to choose from for flights from Iowa to South Carolina.
How old do you have to be to fly from Iowa to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Iowa to South Carolina

Compare and see reviews for airlines that fly from Iowa to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $237	Free Cancellation	Rating 7.1 11,642 reviews	Search American Airlines flights
Delta	PriceFrom $237	Free Cancellation	Rating 7.9 8,398 reviews	Search Delta flights
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 9,771 reviews	Search United Airlines flights
Southwest	PriceFrom $272	Free Cancellation	Rating 8.0 4,255 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Iowa to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Iowa to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Iowa to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Iowa to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Iowa.

I’m not ready to book a flight from Iowa to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Iowa to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.