What is the cheapest airline that flies from Iowa to South Carolina?

United Airlines, Frontier, and Southwest are the most popular carriers operating from Iowa to South Carolina

How many flights depart from Iowa to South Carolina on average per week?

41 flights are operational weekly from Iowa to South Carolina as of September 2026. The most popular departure day for this route is Mon, with 17% of flights per week taking off on this day.

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Iowa according to our data. American Airlines is the first choice among our users, with 63% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How long is the flight from Iowa to South Carolina?

Flight times vary depending on what airport in Iowa you fly out of and what airport in South Carolina you fly into. For example, flying from Des Moines to Charleston takes 4h on average. On the other hand, flying from Cedar Rapids to Charleston takes 4h 32m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

When did momondo last update prices for flights from Iowa to South Carolina?

Prices for flights from Iowa to South Carolina are updated daily.

How many operators does momondo search for flights from Iowa to South Carolina?

As of September 2026, there are 4 operators available to choose from for flights from Iowa to South Carolina.

How old do you have to be to fly from Iowa to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$125 Cheap Flights from Iowa to South Carolina in 2026/27

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Iowa to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

8:00 am - 8:32 amDSM Des Moines-CLT Charlotte Douglas

23h 32m1 stop Philadelphia

5:37 pm - 2:42 pmCLT Charlotte Douglas-DSM Des Moines

22h 05m1 stop Philadelphia

$235Multiple Airlines

Sun, Oct 25 - Wed, Oct 28

3:00 pm - 6:32 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 32mnonstop

10:47 pm - 12:38 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 51mnonstop

$246American Airlines

Wed, Oct 21 - Mon, Oct 26

5:17 pm - 8:51 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 34mnonstop

10:23 am - 12:07 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 44mnonstop

$246American Airlines

Thu, Nov 5 - Tue, Nov 10

3:45 pm - 9:10 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

4h 25m1 stop Chicago Midway

6:20 pm - 9:45 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

4h 25m1 stop Lambert-St Louis

$250Southwest

Tue, Oct 27 - Tue, Nov 10

3:45 pm - 9:10 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

4h 25m1 stop Chicago Midway

7:40 am - 11:35 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

4h 55m1 stop Chicago Midway

$250Southwest

Tue, Oct 20 - Tue, Nov 3

8:10 am - 7:55 amDSM Des Moines-CLT Charlotte Douglas

22h 45m1 stop Philadelphia

5:37 pm - 12:39 pmCLT Charlotte Douglas-DSM Des Moines

20h 02m1 stop Philadelphia

$258Multiple Airlines

Thu, Oct 1 - Sat, Oct 3

4:07 pm - 9:44 pmDSM Des Moines-CHS Charleston

4h 37m1 stop Atlanta Hartsfield-Jackson

3:22 pm - 9:13 pmCHS Charleston-DSM Des Moines

6h 51m1 stop Minneapolis St Paul

$269Delta

Sat, Nov 7 - Tue, Nov 10

8:03 am - 3:13 pmCID Cedar Rapids-SAV Savannah/Hilton Head

6h 10m1 stop Chicago O'Hare Intl

4:57 pm - 10:56 pmSAV Savannah/Hilton Head-CID Cedar Rapids

6h 59m1 stop Chicago O'Hare Intl

$271United Airlines

Wed, Nov 4 - Sat, Nov 7

8:03 am - 3:24 pmCID Cedar Rapids-SAV Savannah/Hilton Head

6h 21m1 stop Chicago O'Hare Intl

4:56 pm - 9:35 pmSAV Savannah/Hilton Head-CID Cedar Rapids

5h 39m1 stop Chicago O'Hare Intl

$271United Airlines

Sat, Nov 7 - Tue, Nov 10

11:00 am - 9:17 pmCID Cedar Rapids-SAV Savannah/Hilton Head

9h 17m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson

5:52 pm - 11:06 pmSAV Savannah/Hilton Head-CID Cedar Rapids

6h 14m1 stop Minneapolis St Paul

$276Delta

Sat, Nov 7 - Tue, Nov 10

Cheap last minute flights

Enter your travel dates to find the best prices.

7:55 am - 2:59 pmCID Cedar Rapids-SAV Savannah/Hilton Head

6h 04m1 stop Chicago O'Hare Intl

6:10 am - 10:13 amSAV Savannah/Hilton Head-CID Cedar Rapids

5h 03m1 stop Chicago O'Hare Intl

$373United Airlines

Sat, Sep 19 - Sat, Oct 3

6:25 am - 7:27 pmCID Cedar Rapids-SAV Savannah/Hilton Head

12h 02m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

3:38 pm - 9:29 pmSAV Savannah/Hilton Head-CID Cedar Rapids

6h 51m1 stop Chicago O'Hare Intl

$378United Airlines

Sat, Sep 19 - Sat, Oct 3

6:15 am - 9:50 amOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 35mnonstop

12:40 pm - 2:13 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 33mnonstop

$395American Airlines

Sat, Sep 19 - Tue, Sep 22

10:26 am - 4:30 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

5h 04m1 stop Chicago O'Hare Intl

12:40 pm - 2:13 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 33mnonstop

$405American Airlines

Sat, Sep 19 - Tue, Sep 22

6:00 am - 1:30 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

6h 30m1 stop Atlanta Hartsfield-Jackson

6:40 am - 12:39 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

6h 59m1 stop Atlanta Hartsfield-Jackson

$415Delta

Sat, Sep 19 - Tue, Sep 22

8:40 am - 7:25 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

9h 45m2 stops Chicago Midway Baltimore/Washington

8:05 am - 11:40 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

4h 35m1 stop Chicago Midway

$420Southwest

Sat, Sep 19 - Tue, Sep 22

11:29 am - 6:59 pmDSM Des Moines-CLT Charlotte Douglas

6h 30m1 stop Denver Intl

7:54 pm - 7:33 pmCLT Charlotte Douglas-DSM Des Moines

24h 39m1 stop Denver Intl

$420Frontier

Thu, Sep 17 - Sun, Sep 20

7:40 am - 6:25 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

9h 45m2 stops Denver Intl Nashville Intl

1:30 pm - 9:50 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

9h 20m2 stops Baltimore/Washington Chicago Midway

$425Southwest

Sat, Sep 19 - Tue, Sep 22

6:00 am - 1:30 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

6h 30m1 stop Atlanta Hartsfield-Jackson

6:40 am - 12:39 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

6h 59m1 stop Atlanta Hartsfield-Jackson

$435Delta

Sat, Sep 19 - Tue, Sep 22

1:58 pm - 9:49 amDSM Des Moines-CLT Charlotte Douglas

18h 51m1 stop Philadelphia

5:37 pm - 7:57 pmCLT Charlotte Douglas-DSM Des Moines

27h 20m1 stop Philadelphia

$444Multiple Airlines

Thu, Sep 17 - Sat, Sep 19

Cheap direct flights

Enter your travel dates to find the best prices.

3:00 pm - 6:32 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 32mnonstop

10:47 pm - 12:38 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 51mnonstop

$246American Airlines

Wed, Oct 21 - Mon, Oct 26

5:17 pm - 8:51 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 34mnonstop

10:23 am - 12:07 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 44mnonstop

$246American Airlines

Thu, Nov 5 - Tue, Nov 10

7:43 am - 11:19 amOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 36mnonstop

10:23 am - 12:07 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 44mnonstop

$246American Airlines

Wed, Nov 11 - Mon, Nov 16

12:57 pm - 4:25 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 28mnonstop

10:23 am - 12:07 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 44mnonstop

$246American Airlines

Tue, Nov 10 - Mon, Nov 16

5:34 pm - 9:08 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 34mnonstop

10:47 pm - 12:38 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 51mnonstop

$339American Airlines

Thu, Oct 15 - Sun, Oct 18

11:33 am - 3:15 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 42mnonstop

8:55 am - 10:48 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 53mnonstop

$339American Airlines

Fri, Nov 20 - Mon, Nov 23

5:34 pm - 9:08 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 34mnonstop

10:47 pm - 12:38 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 51mnonstop

$339American Airlines

Thu, Oct 15 - Sun, Oct 18

7:29 am - 11:05 amOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 36mnonstop

8:40 pm - 10:24 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 44mnonstop

$343American Airlines

Tue, Oct 27 - Tue, Nov 10

3:00 pm - 6:31 pmOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 31mnonstop

8:40 pm - 10:24 pmCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 44mnonstop

$343American Airlines

Tue, Oct 20 - Tue, Nov 10

6:45 am - 10:21 amOMA Omaha Eppley Airfield-CLT Charlotte Douglas

2h 36mnonstop

10:47 pm - 12:38 amCLT Charlotte Douglas-OMA Omaha Eppley Airfield

2h 51mnonstop

$343American Airlines

Sat, Oct 10 - Sat, Oct 17

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American Airlines flights from Iowa to South Carolina

Our best American Airlines deals on Iowa to South Carolina flight tickets

American Airlines

Oct 20

OMA3:00 pmOmaha Eppley Airfield

2h 31m

CLT6:31 pmCharlotte Douglas

Nov 10

CLT8:40 pmCharlotte Douglas

2h 44m

OMA10:24 pmOmaha Eppley Airfield

$229

American Airlines

Oct 21

OMA3:00 pmOmaha Eppley Airfield

2h 32m

CLT6:32 pmCharlotte Douglas

Oct 26

CLT10:47 pmCharlotte Douglas

2h 51m

OMA12:38 amOmaha Eppley Airfield

$246

American Airlines

Oct 20

OMA3:00 pmOmaha Eppley Airfield

2h 31m

CLT6:31 pmCharlotte Douglas

Nov 10

CLT5:05 pmCharlotte Douglas

7h 34m

1 stop

OMA11:39 pmOmaha Eppley Airfield

$256

Southwest flights from Iowa to South Carolina

Our best Southwest deals on Iowa to South Carolina flight tickets

Southwest

Oct 20

OMA3:45 pmOmaha Eppley Airfield

4h 25m

1 stop

CLT9:10 pmCharlotte Douglas

Nov 3

CLT7:40 amCharlotte Douglas

4h 55m

1 stop

OMA11:35 amOmaha Eppley Airfield

$250

Southwest

Oct 20

OMA3:45 pmOmaha Eppley Airfield

4h 25m

1 stop

CLT9:10 pmCharlotte Douglas

Nov 3

CLT1:30 pmCharlotte Douglas

9h 10m

2 stops

OMA9:40 pmOmaha Eppley Airfield

$255

Southwest

Oct 24

OMA5:50 amOmaha Eppley Airfield

6h 15m

2 stops

CLT1:05 pmCharlotte Douglas

Nov 3

CLT6:40 amCharlotte Douglas

8h 10m

2 stops

OMA1:50 pmOmaha Eppley Airfield

$261

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesCharlotte

DSM Des Moines - CLT Charlotte Douglas

DSMCLT

Des Moines

Sun 10/25

8:00 am-8:32 am

1 stop23h 32m

Charlotte Douglas

Wed 10/28

5:37 pm-2:42 pm

1 stop22h 05m

$235

OmahaCharlotte

OMA Omaha Eppley Airfield - CLT Charlotte Douglas

OMACLT

Omaha Eppley Airfield

Wed 10/21

3:00 pm-6:32 pm

Nonstop2h 32m

Charlotte Douglas

Mon 10/26

10:47 pm-12:38 am

Nonstop2h 51m

$246

Quickest round-trip

OmahaCharlotte

OMA Omaha Eppley Airfield - CLT Charlotte Douglas

OMACLT

Omaha Eppley Airfield

Thu 11/5

5:17 pm-8:51 pm

Nonstop2h 34m

Charlotte Douglas

Tue 11/10

10:23 am-12:07 pm

Nonstop2h 44m

$246

OmahaCharlotte

OMA Omaha Eppley Airfield - CLT Charlotte Douglas

OMACLT

Omaha Eppley Airfield

Tue 10/27

3:45 pm-9:10 pm

1 stop4h 25m

Charlotte Douglas

Tue 11/10

6:20 pm-9:45 pm

1 stop4h 25m

$250

OmahaCharlotte

OMA Omaha Eppley Airfield - CLT Charlotte Douglas

OMACLT

Omaha Eppley Airfield

Tue 10/20

3:45 pm-9:10 pm

1 stop4h 25m

Charlotte Douglas

Tue 11/3

7:40 am-11:35 am

1 stop4h 55m

$250

Des MoinesCharlotte

DSM Des Moines - CLT Charlotte Douglas

DSMCLT

Des Moines

Thu 10/1

8:10 am-7:55 am

1 stop22h 45m

Charlotte Douglas

Sat 10/3

5:37 pm-12:39 pm

1 stop20h 02m

$258

Des MoinesCharleston

DSM Des Moines - CHS Charleston

DSMCHS

Des Moines

Sat 11/7

4:07 pm-9:44 pm

1 stop4h 37m

Charleston

Tue 11/10

3:22 pm-9:13 pm

1 stop6h 51m

$269

Cedar RapidsSavannah

CID Cedar Rapids - SAV Savannah/Hilton Head

CIDSAV

Cedar Rapids

Wed 11/4

8:03 am-3:13 pm

1 stop6h 10m

Savannah/Hilton Head

Sat 11/7

4:57 pm-10:56 pm

1 stop6h 59m

$271

Cedar RapidsSavannah

CID Cedar Rapids - SAV Savannah/Hilton Head

CIDSAV

Cedar Rapids

Sat 11/7

8:03 am-3:24 pm

1 stop6h 21m

Savannah/Hilton Head

Tue 11/10

4:56 pm-9:35 pm

1 stop5h 39m

$271

Cedar RapidsSavannah

CID Cedar Rapids - SAV Savannah/Hilton Head

CIDSAV

Cedar Rapids

Sat 11/7

11:00 am-9:17 pm

2 stops9h 17m

Savannah/Hilton Head

Tue 11/10

5:52 pm-11:06 pm

1 stop6h 14m

$276

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Iowa to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Iowa is in February. Flight prices, which tend to average around $317, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of February, then book flights to South Carolina from Iowa during September instead. Flights to South Carolina in September, while not as cheap as those in February, still average around $359.

Can stopping save me money on Iowa to South Carolina flights?

You could potentially save up to 36% on your flight if you consider stops on a Iowa to South Carolina flight.

Cheap Iowa to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to South Carolina

Best Price Found	$125
Fastest flight time	2h 13m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Iowa in the past 72 hours is $125. The best round-trip flight deal from Iowa to South Carolina found on momondo in the last 72 hours is $235.

The fastest flight from Iowa to South Carolina takes 2h 13m

Direct flights go from Iowa to South Carolina every day.

There are 57 airports in South Carolina. From Iowa there are direct flights to Charlotte Douglas (CLT).

Search flight deals

Frequently asked questions about flying from Iowa to South Carolina

When did momondo last update prices for flights from Iowa to South Carolina?
Prices for flights from Iowa to South Carolina are updated daily.
How many operators does momondo search for flights from Iowa to South Carolina?
As of September 2026, there are 4 operators available to choose from for flights from Iowa to South Carolina.
How old do you have to be to fly from Iowa to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Iowa to South Carolina

Compare and see reviews for airlines that fly from Iowa to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 10,208 reviews	Search United Airlines flights
American Airlines	PriceFrom $248	Free Cancellation	Rating 7.1 12,058 reviews	Search American Airlines flights
Delta	PriceFrom $260	Free Cancellation	Rating 7.8 8,568 reviews	Search Delta flights
Southwest	PriceFrom $344	Free Cancellation	Rating 8.0 4,190 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Iowa to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Iowa to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Iowa to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Iowa to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Iowa.

I’m not ready to book a flight from Iowa to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Iowa to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.