What is the cheapest airline that flies from Iowa to South Carolina?

Delta, American Airlines, and Southwest are the most popular carriers operating from Iowa to South Carolina

How long is the flight from Iowa to South Carolina?

Flight times vary depending on what airport in Iowa you fly out of and what airport in South Carolina you fly into. For example, flying from Des Moines to Charleston takes 3h 45m on average. On the other hand, flying from Cedar Rapids to Charleston takes 4h 57m on average. Keep in mind that it’s always quicker to opt for a non-stop flight, so be sure to check momondo if there are any available for your route.

How many flights depart from Iowa to South Carolina on average per week?

53 flights are operational weekly from Iowa to South Carolina as of June 2025. The most popular departure day for this route is Tue, with 15% of flights per week taking off on this day.

What airlines fly to South Carolina?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to South Carolina from Iowa according to our data. American Airlines is the first choice among our users, with 70% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Iowa to South Carolina?

Prices for flights from Iowa to South Carolina are updated daily.

How many operators does momondo search for flights from Iowa to South Carolina?

As of June 2025, there are 4 operators available to choose from for flights from Iowa to South Carolina.

How old do you have to be to fly from Iowa to South Carolina?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$104 Cheap Flights from Iowa to South Carolina in 2025

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Find the cheapest flights from Iowa to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

12:25 pm - 6:00 pmOMA-CLT

4h 35m1 stop

7:50 pm - 10:55 pmCLT-OMA

4h 05m1 stop

$144Southwest

Find Deal

Tue, Sep 16 - Thu, Sep 18

8:25 am - 6:00 pmDSM-CLT

8h 35m1 stop

5:25 pm - 10:20 pmCLT-DSM

5h 55m1 stop

$150Southwest

Find Deal

Wed, Aug 20 - Wed, Aug 27

6:30 am - 1:31 pmDSM-CHS

6h 01m1 stop

1:06 pm - 5:25 pmCHS-DSM

5h 19m1 stop

$217American Airlines

Find Deal

Tue, Aug 5 - Thu, Aug 7

5:29 pm - 11:11 pmDSM-MYR

4h 42m1 stop

7:03 pm - 11:50 pmMYR-DSM

5h 47m1 stop

$217American Airlines

Find Deal

Tue, Aug 12 - Tue, Aug 19

8:35 am - 4:48 pmDSM-CLT

7h 13m1 stop

9:24 am - 6:06 pmCLT-DSM

9h 42m1 stop

$224

Find Deal

Fri, Jul 4 - Fri, Jul 11

8:35 am - 4:48 pmDSM-CLT

7h 13m1 stop

6:20 am - 6:06 pmCLT-DSM

12h 46m2 stops

$230

Find Deal

Fri, Jul 4 - Fri, Jul 11

6:20 am - 4:51 pmDSM-CHS

9h 31m2 stops

7:20 am - 5:13 pmCHS-DSM

10h 53m2 stops

$254Delta

Find Deal

Sat, Oct 11 - Tue, Oct 14

7:00 am - 2:08 pmCID-CHS

6h 08m1 stop

5:30 am - 11:33 amCHS-CID

7h 03m2 stops

$271Delta

Find Deal

Tue, Dec 2 - Sat, Dec 6

6:37 am - 2:02 pmCID-CHS

6h 25m1 stop

6:05 am - 10:40 amCHS-CID

5h 35m1 stop

$309United Airlines

Find Deal

Mon, Jul 28 - Sat, Aug 2

6:00 am - 2:35 pmOMA-MYR

7h 35m1 stop

4:50 pm - 9:52 pmMYR-OMA

6h 02m1 stop

$353United Airlines

Find Deal

Tue, Jul 8 - Tue, Jul 15

Frontier flights from Iowa to South Carolina

Our best Frontier deals on Iowa to South Carolina flight tickets

Frontier

Aug 21

CID8:22 pmCedar Rapids

19h 15m

1 stop

CLT4:37 pmCharlotte Douglas

Aug 24

CLT5:32 pmCharlotte Douglas

27h 05m

1 stop

CID7:37 pmCedar Rapids

$318

Find similar

Frontier

Sep 21

DSM8:41 pmDes Moines

18h 51m

1 stop

CLT4:32 pmCharlotte Douglas

Sep 28

CLT5:34 pmCharlotte Douglas

27h 22m

1 stop

DSM7:56 pmDes Moines

$360

Find similar

Frontier

Sep 25

OMA8:47 pmOmaha Eppley Airfield

18h 45m

1 stop

CLT4:32 pmCharlotte Douglas

Sep 28

CLT5:34 pmCharlotte Douglas

27h 18m

1 stop

OMA7:52 pmOmaha Eppley Airfield

$376

Find similar

American Airlines flights from Iowa to South Carolina

Our best American Airlines deals on Iowa to South Carolina flight tickets

American Airlines

Aug 5

DSM6:30 amDes Moines

6h 01m

1 stop

CHS1:31 pmCharleston

Aug 7

CHS1:06 pmCharleston

5h 19m

1 stop

DSM5:25 pmDes Moines

$217

Find similar

American Airlines

Aug 5

DSM5:00 amDes Moines

8h 53m

2 stops

CHS2:53 pmCharleston

Aug 7

CHS1:06 pmCharleston

5h 19m

1 stop

DSM5:25 pmDes Moines

$222

Find similar

American Airlines

Sep 10

DSM7:02 amDes Moines

8h 43m

2 stops

CHS4:45 pmCharleston

Sep 24

CHS10:32 amCharleston

8h 57m

2 stops

DSM6:29 pmDes Moines

$227

Find similar

How to get the cheapest flight ticket from Iowa to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Iowa is in May. Flight prices, which tend to average around $341, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of May, then book flights to South Carolina from Iowa during September instead. Flights to South Carolina in September, while not as cheap as those in May, still average around $343.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $379. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Iowa to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $386. Try not to purchase tickets in the morning because they tend to be around $405. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Iowa when booking 10 weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $393 when searching 10 weeks out.However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Iowa for as low as $314 on momondo.

Can stopping save me money on Iowa to South Carolina flights?

You could potentially save up to 40% on your flight if you consider stops on a Iowa to South Carolina flight.

Cheap Iowa to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to South Carolina

Best Price Found	$104
Fastest flight time	2h 07m
Direct flights	Every day
Airports in South Carolina	3 airports

The best one-way flight to South Carolina from Iowa in the past 72 hours is $104. The best round-trip flight deal from Iowa to South Carolina found on momondo in the last 72 hours is $144.

The fastest flight from Iowa to South Carolina takes 2h 07m

Direct flights go from Iowa to South Carolina every day.

There are 3 airports near South Carolina: Myrtle Beach Intl (MYR), Charlotte Douglas (CLT), Charleston (CHS)

Search flight deals

When did momondo last update prices for flights from Iowa to South Carolina?
Prices for flights from Iowa to South Carolina are updated daily.
How many operators does momondo search for flights from Iowa to South Carolina?
As of June 2025, there are 4 operators available to choose from for flights from Iowa to South Carolina.
How old do you have to be to fly from Iowa to South Carolina?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Best airlines flying from Iowa to South Carolina

Compare and see reviews for airlines that fly from Iowa to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $198	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
Delta	PriceFrom $232	Free Cancellation	Rating 8.0 7,963 reviews	Search Delta flights
United Airlines	PriceFrom $235	Free Cancellation	Rating 7.4 8,801 reviews	Search United Airlines flights
Southwest	PriceFrom $376	Free Cancellation	Rating 8.0 4,278 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Iowa to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Iowa to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Iowa to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Iowa to South Carolina?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South Carolina from Iowa.

I’m not ready to book a flight from Iowa to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Iowa to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.