How long does it take to fly to Knoxville?

Average flight duration from Iowa to Knoxville depends on which airport you fly into and out of. Flying from Des Moines to Knoxville is 4h 14m on average, while flying from Cedar Rapids to Knoxville is 4h 20m on average. Knoxville is the most popular airport in Knoxville.

What is the cheapest airline that flies from Iowa to Knoxville McGhee Tyson?

Delta, United Airlines, and Allegiant Air are the most popular carriers operating from Iowa to Knoxville McGhee Tyson

What airlines fly to Knoxville?

American Airlines, United Airlines and Delta are the top three most popular airlines that fly to Knoxville from Iowa according to our data. American Airlines is the first choice among our users, with 53% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 3 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Iowa to Knoxville McGhee Tyson Airport?

Prices for flights from Iowa to Knoxville McGhee Tyson Airport are updated daily.

How many operators does momondo search for flights from Iowa to Knoxville McGhee Tyson Airport?

As of September 2026, there are 4 operators available to choose from for flights from Iowa to Knoxville McGhee Tyson Airport.

How old do you have to be to fly from Iowa to Knoxville McGhee Tyson Airport?

The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Knoxville McGhee Tyson Airport.

What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

$144 Cheap Flights from Iowa to Knoxville in 2026

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Iowa to Knoxville

Round-trip

One-way

Last minute

Cheap round-trip flights

Enter your travel dates to find the best prices.

10:30 am - 7:24 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

7h 54m1 stop Fort Lauderdale

12:19 pm - 5:14 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

5h 55m1 stop Sarasota Bradenton Intl

$231Allegiant Air

Mon, Oct 26 - Thu, Oct 29

8:51 pm - 1:11 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

15h 20m1 stop Denver Intl

12:19 pm - 5:14 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

5h 55m1 stop Sarasota Bradenton Intl

$240Multiple Airlines

Sat, Oct 24 - Thu, Oct 29

3:02 pm - 9:55 pmDSM Des Moines-TYS Knoxville McGhee Tyson

5h 53m1 stop Houston George Bush Intcntl

6:00 am - 10:31 amTYS Knoxville McGhee Tyson-DSM Des Moines

5h 31m1 stop Chicago O'Hare Intl

$283United Airlines

Tue, Sep 29 - Wed, Sep 30

1:26 pm - 8:49 pmDSM Des Moines-TYS Knoxville McGhee Tyson

6h 23m1 stop Chicago O'Hare Intl

6:03 pm - 9:23 pmTYS Knoxville McGhee Tyson-DSM Des Moines

4h 20m1 stop Chicago O'Hare Intl

$287United Airlines

Sat, Oct 17 - Sat, Oct 24

2:07 pm - 9:37 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

6h 30m1 stop Detroit Metropolitan Wayne County

6:23 pm - 11:59 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

6h 36m1 stop Atlanta Hartsfield-Jackson

$287Delta

Wed, Oct 28 - Thu, Oct 29

12:11 pm - 8:08 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

6h 57m1 stop Atlanta Hartsfield-Jackson

12:06 pm - 4:48 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

5h 42m1 stop Atlanta Hartsfield-Jackson

$287Delta

Sat, Oct 24 - Wed, Oct 28

4:12 pm - 11:18 pmDSM Des Moines-TYS Knoxville McGhee Tyson

6h 06m1 stop Dallas/Fort Worth

7:11 am - 2:31 pmTYS Knoxville McGhee Tyson-DSM Des Moines

8h 20m1 stop Washington, D.C. Reagan-National

$287American Airlines

Sat, Oct 17 - Sat, Oct 24

2:26 pm - 9:33 pmDSM Des Moines-TYS Knoxville McGhee Tyson

6h 07m1 stop Washington, D.C. Reagan-National

6:06 pm - 11:58 pmTYS Knoxville McGhee Tyson-DSM Des Moines

6h 52m1 stop Charlotte Douglas

$287American Airlines

Wed, Oct 21 - Sat, Oct 24

6:00 am - 7:45 pmDSM Des Moines-TYS Knoxville McGhee Tyson

12h 45m2 stops Chicago Midway Nashville Intl

1:00 pm - 10:00 pmTYS Knoxville McGhee Tyson-DSM Des Moines

10h 00m2 stops Orlando Chicago Midway

$331Southwest

Wed, Nov 4 - Tue, Nov 10

1:45 pm - 10:45 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

8h 00m2 stops Chicago Midway Nashville Intl

7:15 am - 7:00 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

12h 45m2 stops Nashville Intl Denver Intl

$359Southwest

Mon, Oct 26 - Thu, Oct 29

Cheap last minute flights

Enter your travel dates to find the best prices.

4:03 pm - 10:50 pmMLI Moline Quad-City-TYS Knoxville McGhee Tyson

5h 47m1 stop Charlotte Douglas

8:14 pm - 12:05 amTYS Knoxville McGhee Tyson-MLI Moline Quad-City

4h 51m1 stop Chicago O'Hare Intl

$424American Airlines

Tue, Sep 15 - Tue, Sep 22

6:00 am - 11:18 amMLI Moline Quad-City-TYS Knoxville McGhee Tyson

4h 18m1 stop Atlanta Hartsfield-Jackson

6:13 pm - 10:30 pmTYS Knoxville McGhee Tyson-MLI Moline Quad-City

5h 17m1 stop Atlanta Hartsfield-Jackson

$424Delta

Tue, Sep 15 - Tue, Sep 22

4:03 pm - 10:50 pmMLI Moline Quad-City-TYS Knoxville McGhee Tyson

5h 47m1 stop Charlotte Douglas

7:15 am - 4:27 pmTYS Knoxville McGhee Tyson-MLI Moline Quad-City

10h 12m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl

$429American Airlines

Tue, Sep 15 - Tue, Sep 22

10:24 am - 2:31 pmDSM Des Moines-TYS Knoxville McGhee Tyson

27h 07m1 stop Orlando Sanford Intl

5:38 pm - 9:09 amTYS Knoxville McGhee Tyson-DSM Des Moines

16h 31m1 stop Orlando Sanford Intl

$503Allegiant Air

Mon, Sep 14 - Thu, Sep 17

5:21 pm - 2:31 pmCID Cedar Rapids-TYS Knoxville McGhee Tyson

20h 10m1 stop Orlando Sanford Intl

5:38 pm - 4:30 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

23h 52m1 stop Orlando Sanford Intl

$522Allegiant Air

Mon, Sep 14 - Thu, Sep 17

6:00 am - 1:18 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

6h 18m1 stop Chicago O'Hare Intl

9:00 am - 4:28 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

8h 28m1 stop Denver Intl

$609United Airlines

Tue, Sep 15 - Wed, Sep 16

10:30 am - 7:00 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

7h 30m2 stops Chicago Midway Nashville Intl

3:00 pm - 8:55 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

6h 55m1 stop Denver Intl

$614Southwest

Tue, Sep 15 - Wed, Sep 16

10:30 am - 7:00 pmOMA Omaha Eppley Airfield-TYS Knoxville McGhee Tyson

7h 30m2 stops Chicago Midway Nashville Intl

12:45 pm - 9:50 pmTYS Knoxville McGhee Tyson-OMA Omaha Eppley Airfield

10h 05m2 stops Orlando Chicago Midway

$619Southwest

Tue, Sep 15 - Wed, Sep 16

11:32 am - 4:58 pmDSM Des Moines-TYS Knoxville McGhee Tyson

4h 26m1 stop Chicago O'Hare Intl

5:45 am - 12:34 pmTYS Knoxville McGhee Tyson-DSM Des Moines

7h 49m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$632United Airlines

Tue, Sep 15 - Thu, Sep 24

4:19 pm - 11:55 pmCID Cedar Rapids-TYS Knoxville McGhee Tyson

6h 36m2 stops Minneapolis St Paul Atlanta Hartsfield-Jackson

4:57 pm - 9:53 pmTYS Knoxville McGhee Tyson-CID Cedar Rapids

5h 56m1 stop Atlanta Hartsfield-Jackson

$872Delta

Mon, Sep 14 - Fri, Sep 18

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United Airlines flights from Iowa to Knoxville

Our best United Airlines deals on Iowa to Knoxville flight tickets

United Airlines

Sep 29

DSM3:02 pmDes Moines

5h 53m

1 stop

TYS9:55 pmKnoxville McGhee Tyson

Sep 30

TYS6:00 amKnoxville McGhee Tyson

5h 31m

1 stop

DSM10:31 amDes Moines

$283

United Airlines

Oct 17

DSM1:26 pmDes Moines

6h 23m

1 stop

TYS8:49 pmKnoxville McGhee Tyson

Oct 24

TYS6:03 pmKnoxville McGhee Tyson

4h 20m

1 stop

DSM9:23 pmDes Moines

$287

United Airlines

Oct 17

DSM11:27 amDes Moines

7h 52m

2 stops

TYS8:19 pmKnoxville McGhee Tyson

Oct 24

TYS10:42 amKnoxville McGhee Tyson

4h 33m

1 stop

DSM2:15 pmDes Moines

$292

Allegiant Air flights from Iowa to Knoxville

Our best Allegiant Air deals on Iowa to Knoxville flight tickets

Allegiant Air

Oct 26

OMA10:30 amOmaha Eppley Airfield

7h 54m

1 stop

TYS7:24 pmKnoxville McGhee Tyson

Oct 29

TYS12:19 pmKnoxville McGhee Tyson

5h 55m

1 stop

OMA5:14 pmOmaha Eppley Airfield

$231

Allegiant Air

Sep 27

DSM1:58 pmDes Moines

28h 36m

1 stop

TYS7:34 pmKnoxville McGhee Tyson

Oct 1

TYS2:06 pmKnoxville McGhee Tyson

8h 25m

1 stop

DSM9:31 pmDes Moines

$264

Allegiant Air

Dec 13

DSM7:15 amDes Moines

11h 20m

1 stop

TYS7:35 pmKnoxville McGhee Tyson

Dec 18

TYS9:18 amKnoxville McGhee Tyson

7h 13m

1 stop

DSM3:31 pmDes Moines

$317

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

OmahaKnoxville

OMA Omaha Eppley Airfield - TYS Knoxville McGhee Tyson

OMATYS

Omaha Eppley Airfield

Mon 10/26

10:30 am-7:24 pm

1 stop7h 54m

Knoxville McGhee Tyson

Thu 10/29

12:19 pm-5:14 pm

1 stop5h 55m

$231

OmahaKnoxville

OMA Omaha Eppley Airfield - TYS Knoxville McGhee Tyson

OMATYS

Omaha Eppley Airfield

Sat 10/24

8:51 pm-1:11 pm

1 stop15h 20m

Knoxville McGhee Tyson

Thu 10/29

12:19 pm-5:14 pm

1 stop5h 55m

$240

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Tue 9/29

3:02 pm-9:55 pm

1 stop5h 53m

Knoxville McGhee Tyson

Wed 9/30

6:00 am-10:31 am

1 stop5h 31m

$283

Quickest round-trip

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Sat 10/17

1:26 pm-8:49 pm

1 stop6h 23m

Knoxville McGhee Tyson

Sat 10/24

6:03 pm-9:23 pm

1 stop4h 20m

$287

OmahaKnoxville

OMA Omaha Eppley Airfield - TYS Knoxville McGhee Tyson

OMATYS

Omaha Eppley Airfield

Wed 10/28

2:07 pm-9:37 pm

1 stop6h 30m

Knoxville McGhee Tyson

Thu 10/29

6:23 pm-11:59 pm

1 stop6h 36m

$287

OmahaKnoxville

OMA Omaha Eppley Airfield - TYS Knoxville McGhee Tyson

OMATYS

Omaha Eppley Airfield

Sat 10/24

12:11 pm-8:08 pm

1 stop6h 57m

Knoxville McGhee Tyson

Wed 10/28

12:06 pm-4:48 pm

1 stop5h 42m

$287

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Sat 10/17

4:12 pm-11:18 pm

1 stop6h 06m

Knoxville McGhee Tyson

Sat 10/24

7:11 am-2:31 pm

1 stop8h 20m

$287

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Wed 10/21

2:26 pm-9:33 pm

1 stop6h 07m

Knoxville McGhee Tyson

Sat 10/24

6:06 pm-11:58 pm

1 stop6h 52m

$287

Des MoinesKnoxville

DSM Des Moines - TYS Knoxville McGhee Tyson

DSMTYS

Des Moines

Wed 11/4

6:00 am-7:45 pm

2 stops12h 45m

Knoxville McGhee Tyson

Tue 11/10

1:00 pm-10:00 pm

2 stops10h 00m

$331

OmahaKnoxville

OMA Omaha Eppley Airfield - TYS Knoxville McGhee Tyson

OMATYS

Omaha Eppley Airfield

Mon 10/26

1:45 pm-10:45 pm

2 stops8h 00m

Knoxville McGhee Tyson

Thu 10/29

7:15 am-7:00 pm

2 stops12h 45m

$359

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Iowa to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Iowa, with most prices found around $265. If you aren’t able to travel during the month of January, then book flights to Knoxville from Iowa during November instead. Flights to Knoxville in November, while not as cheap as those in January, still average around $318.

Cheap Iowa to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Knoxville

Best Price Found	$144
Fastest flight time	4h 14m
Direct flights	None

The best one-way flight to Knoxville from Iowa in the past 72 hours is $144. The best round-trip flight deal from Iowa to Knoxville found on momondo in the last 72 hours is $231.

The fastest flight from Iowa to Knoxville takes 4h 14m

There are no direct flights from Iowa to Knoxville. There are no popular flight routes from Iowa to Knoxville.

Search flight deals

Frequently asked questions about flying from Iowa to Knoxville

When did momondo last update prices for flights from Iowa to Knoxville McGhee Tyson Airport?
Prices for flights from Iowa to Knoxville McGhee Tyson Airport are updated daily.
How many operators does momondo search for flights from Iowa to Knoxville McGhee Tyson Airport?
As of September 2026, there are 4 operators available to choose from for flights from Iowa to Knoxville McGhee Tyson Airport.
How old do you have to be to fly from Iowa to Knoxville McGhee Tyson Airport?
The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Knoxville McGhee Tyson Airport.
What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?
The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Knoxville

Compare and see reviews for airlines that fly from Iowa to Knoxville with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $203	Free Cancellation	Rating 7.1 12,049 reviews	Search American Airlines flights
Delta	PriceFrom $203	Free Cancellation	Rating 7.8 8,566 reviews	Search Delta flights
United Airlines	PriceFrom $248	Free Cancellation	Rating 7.4 10,214 reviews	Search United Airlines flights

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Bryson City

Morristown

Corbin

Alcoa

Maryville

Crossville

Murphy

Oak Ridge

Kodak

Newport

Dandridge

Clinton

Lenoir City

Rockford

Jefferson City

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Why should I use momondo to find a flight deal from Iowa to Knoxville?

It is quick and easy to find Iowa to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Iowa to Knoxville with flexible booking policies on momondo?

All flight searches from Iowa to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Knoxville?

Once you have performed a search for Iowa to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Iowa to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Iowa to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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Cheap flights from Iowa to Knoxville from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Knoxville departing on 10/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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An easier way to manage your Knoxville trip

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