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Cheap flights from Iowa to Knoxville from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Knoxville departing on 5/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Iowa to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
5:02 pm - 9:50 pm
DSM
-
TYS
27h 48m
1 stop
Allegiant Air Logo
4:05 pm - 10:52 pm
TYS
-
DSM
7h 47m
1 stop
$253Allegiant Air
Thu, Jun 25 - Sun, Jun 28
Multiple Airlines Logo
2:16 pm - 1:52 pm
DSM
-
TYS
22h 36m
1 stop
Multiple Airlines Logo
1:41 pm - 11:27 pm
TYS
-
DSM
10h 46m
1 stop
$257Multiple Airlines
Wed, Jun 3 - Mon, Jun 8
United Airlines Logo
11:10 am - 4:54 pm
CID
-
TYS
4h 44m
1 stop
United Airlines Logo
7:00 am - 10:26 am
TYS
-
CID
4h 26m
1 stop
$291United Airlines
Sat, May 2 - Sat, May 9
American Airlines Logo
12:48 pm - 8:18 pm
CID
-
TYS
6h 30m
1 stop
American Airlines Logo
7:12 pm - 11:30 pm
TYS
-
CID
5h 18m
1 stop
$293American Airlines
Wed, May 20 - Sat, May 30
Delta Logo
6:31 pm - 11:54 pm
DSM
-
TYS
4h 23m
1 stop
Delta Logo
6:36 am - 12:24 pm
TYS
-
DSM
6h 48m
1 stop
$295Delta
Wed, May 6 - Wed, May 13
Delta Logo
12:34 pm - 9:20 pm
CID
-
TYS
7h 46m
2 stops
Delta Logo
6:36 am - 11:16 am
TYS
-
CID
5h 40m
1 stop
$296Delta
Sat, May 2 - Sat, May 9
American Airlines Logo
12:48 pm - 8:18 pm
CID
-
TYS
6h 30m
1 stop
American Airlines Logo
6:07 pm - 11:30 pm
TYS
-
CID
6h 23m
2 stops
$298American Airlines
Wed, May 20 - Sat, May 30
Southwest Logo
10:20 am - 9:10 pm
OMA
-
TYS
9h 50m
2 stops
Southwest Logo
12:45 pm - 10:30 pm
TYS
-
OMA
10h 45m
2 stops
$336Southwest
Fri, Jun 19 - Tue, Jun 23
Southwest Logo
10:20 am - 9:10 pm
OMA
-
TYS
9h 50m
2 stops
Southwest Logo
7:10 am - 3:10 pm
TYS
-
OMA
9h 00m
1 stop
$337Southwest
Fri, Jun 19 - Tue, Jun 23
United Airlines Logo
6:25 pm - 12:30 am
OMA
-
TYS
5h 05m
1 stop
United Airlines Logo
8:20 am - 2:17 pm
TYS
-
OMA
6h 57m
1 stop
$345United Airlines
Fri, Jun 19 - Wed, Jun 24

Delta flights from Iowa to Knoxville

Our best Delta deals on Iowa to Knoxville flight tickets
Delta
May 6
DSM6:31 pmDes Moines
4h 23m
1 stop
TYS11:54 pmKnoxville McGhee Tyson
May 13
TYS6:36 amKnoxville McGhee Tyson
6h 48m
1 stop
DSM12:24 pmDes Moines
$295
Delta
May 23
CID4:11 pmCedar Rapids
6h 50m
2 stops
TYS12:01 amKnoxville McGhee Tyson
Jun 2
TYS3:30 pmKnoxville McGhee Tyson
6h 44m
1 stop
CID9:14 pmCedar Rapids
$300
Delta
May 19
CID6:57 amCedar Rapids
6h 23m
2 stops
TYS2:20 pmKnoxville McGhee Tyson
May 27
TYS3:30 pmKnoxville McGhee Tyson
6h 44m
1 stop
CID9:14 pmCedar Rapids
$323

United Airlines flights from Iowa to Knoxville

Our best United Airlines deals on Iowa to Knoxville flight tickets
United Airlines
May 7
CID11:10 amCedar Rapids
4h 44m
1 stop
TYS4:54 pmKnoxville McGhee Tyson
May 12
TYS5:55 pmKnoxville McGhee Tyson
4h 43m
1 stop
CID9:38 pmCedar Rapids
$310
United Airlines
Jun 27
CID6:50 pmCedar Rapids
4h 45m
1 stop
TYS12:35 amKnoxville McGhee Tyson
Jul 1
TYS6:30 amKnoxville McGhee Tyson
5h 03m
1 stop
CID10:33 amCedar Rapids
$315
United Airlines
Apr 29
CID8:00 amCedar Rapids
4h 14m
1 stop
TYS1:14 pmKnoxville McGhee Tyson
May 2
TYS7:00 amKnoxville McGhee Tyson
4h 27m
1 stop
CID10:27 amCedar Rapids
$325

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 11, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 6/25

5:02 pm-9:50 pm

1 stop27h 48m

Knoxville McGhee Tyson

Sun 6/28

4:05 pm-10:52 pm

1 stop7h 47m

$253

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 6/3

2:16 pm-1:52 pm

1 stop22h 36m

Knoxville McGhee Tyson

Mon 6/8

1:41 pm-11:27 pm

1 stop10h 46m

$257
Quickest round-trip

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sat 5/2

11:10 am-4:54 pm

1 stop4h 44m

Knoxville McGhee Tyson

Sat 5/9

7:00 am-10:26 am

1 stop4h 26m

$291

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Wed 5/20

12:48 pm-8:18 pm

1 stop6h 30m

Knoxville McGhee Tyson

Sat 5/30

7:12 pm-11:30 pm

1 stop5h 18m

$293

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 5/6

6:31 pm-11:54 pm

1 stop4h 23m

Knoxville McGhee Tyson

Wed 5/13

6:36 am-12:24 pm

1 stop6h 48m

$295

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sat 5/2

12:34 pm-9:20 pm

2 stops7h 46m

Knoxville McGhee Tyson

Sat 5/9

6:36 am-11:16 am

1 stop5h 40m

$296

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Wed 5/20

12:48 pm-8:18 pm

1 stop6h 30m

Knoxville McGhee Tyson

Sat 5/30

6:07 pm-11:30 pm

2 stops6h 23m

$298

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Fri 6/19

10:20 am-9:10 pm

2 stops9h 50m

Knoxville McGhee Tyson

Tue 6/23

12:45 pm-10:30 pm

2 stops10h 45m

$336

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Fri 6/19

10:20 am-9:10 pm

2 stops9h 50m

Knoxville McGhee Tyson

Tue 6/23

7:10 am-3:10 pm

1 stop9h 00m

$337

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Fri 6/19

6:25 pm-12:30 am

1 stop5h 05m

Knoxville McGhee Tyson

Wed 6/24

8:20 am-2:17 pm

1 stop6h 57m

$345

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Iowa to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Can stopping save me money on Iowa to Knoxville flights?

You could potentially save up to 73% on your flight if you consider stops on a Iowa to Knoxville flight.

Cheap Iowa to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Knoxville

Fastest flight time

4h 08m

Direct flights

None
The fastest flight from Iowa to Knoxville takes 4h 08m
There are no direct flights from Iowa to Knoxville. There are no popular flight routes from Iowa to Knoxville.
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Frequently asked questions about flying from Iowa to Knoxville

  • When did momondo last update prices for flights from Iowa to Knoxville McGhee Tyson Airport?

    Prices for flights from Iowa to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Iowa to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Iowa to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Knoxville

Compare and see reviews for airlines that fly from Iowa to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.1
11,572 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.9
8,406 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,569 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Knoxville?

It is quick and easy to find Iowa to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Iowa to Knoxville with flexible booking policies on momondo?

All flight searches from Iowa to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Knoxville?

Once you have performed a search for Iowa to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Iowa to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Iowa to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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