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Cheap flights from Iowa to Knoxville from $139

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Knoxville departing on 12/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Iowa to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:00 pm - 11:50 pmMLI-TYS
5h 50m1 stop
Delta Logo
12:00 pm - 4:20 pmTYS-MLI
5h 20m1 stop
$249Delta
Find Deal
Sat, Feb 21 - Wed, Feb 25
Multiple Airlines Logo
2:56 pm - 8:33 amDSM-TYS
16h 37m1 stop
Multiple Airlines Logo
4:52 pm - 7:03 pmTYS-DSM
27h 11m1 stop
$256Multiple Airlines
Find Deal
Thu, Dec 4 - Sun, Dec 7
United Airlines Logo
1:10 pm - 8:46 pmCID-TYS
6h 36m1 stop
United Airlines Logo
7:00 am - 12:04 pmTYS-CID
6h 04m1 stop
$266United Airlines
Find Deal
Fri, Apr 3 - Sun, Apr 5
United Airlines Logo
8:00 am - 1:17 pmOMA-TYS
4h 17m1 stop
United Airlines Logo
9:40 am - 5:29 pmTYS-OMA
8h 49m2 stops
$282United Airlines
Find Deal
Tue, Dec 2 - Sat, Dec 6
American Airlines Logo
2:50 pm - 10:51 pmCID-TYS
7h 01m1 stop
American Airlines Logo
6:30 am - 1:32 pmTYS-CID
8h 02m1 stop
$294American Airlines
Find Deal
Mon, Nov 24 - Fri, Nov 28
Allegiant Air Logo
10:09 am - 4:33 pmMLI-TYS
5h 24m1 stop
Allegiant Air Logo
8:20 am - 6:23 pmTYS-MLI
11h 03m1 stop
$301Allegiant Air
Find Deal
Thu, Dec 11 - Mon, Dec 15
Allegiant Air Logo
7:30 am - 10:21 pmDSM-TYS
13h 51m1 stop
Allegiant Air Logo
2:00 pm - 11:07 pmTYS-DSM
10h 07m1 stop
$301Allegiant Air
Find Deal
Fri, Jan 23 - Sun, Jan 25
American Airlines Logo
2:07 pm - 10:51 pmOMA-TYS
7h 44m2 stops
American Airlines Logo
5:05 am - 1:37 pmTYS-OMA
9h 32m2 stops
$308American Airlines
Find Deal
Tue, Dec 2 - Sat, Dec 6
Southwest Logo
5:30 am - 5:05 pmOMA-TYS
10h 35m2 stops
Southwest Logo
6:35 am - 4:10 pmTYS-OMA
10h 35m1 stop
$358Southwest
Find Deal
Tue, Apr 14 - Mon, Apr 20
Southwest Logo
5:20 am - 1:10 pmDSM-TYS
6h 50m2 stops
Southwest Logo
6:40 am - 1:30 pmTYS-DSM
7h 50m2 stops
$363Southwest
Find Deal
Sat, Apr 4 - Sat, Apr 11

Delta flights from Iowa to Knoxville

Our best Delta deals on Iowa to Knoxville flight tickets
Delta
Feb 21
MLI5:00 pmMoline Quad-City
5h 50m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Feb 25
TYS12:00 pmKnoxville McGhee Tyson
5h 20m
1 stop
MLI4:20 pmMoline Quad-City
$249
Find similar
Delta
Feb 21
MLI5:00 pmMoline Quad-City
5h 50m
1 stop
TYS11:50 pmKnoxville McGhee Tyson
Feb 25
TYS12:00 pmKnoxville McGhee Tyson
5h 20m
1 stop
MLI4:20 pmMoline Quad-City
$264
Find similar
Delta
Feb 18
DSM7:34 amDes Moines
7h 45m
1 stop
TYS4:19 pmKnoxville McGhee Tyson
Feb 21
TYS6:20 amKnoxville McGhee Tyson
4h 57m
1 stop
DSM10:17 amDes Moines
$271
Find similar

United Airlines flights from Iowa to Knoxville

Our best United Airlines deals on Iowa to Knoxville flight tickets
United Airlines
Apr 3
CID1:10 pmCedar Rapids
6h 36m
1 stop
TYS8:46 pmKnoxville McGhee Tyson
Apr 5
TYS7:00 amKnoxville McGhee Tyson
6h 04m
1 stop
CID12:04 pmCedar Rapids
$266
Find similar
United Airlines
Dec 2
OMA8:00 amOmaha Eppley Airfield
4h 17m
1 stop
TYS1:17 pmKnoxville McGhee Tyson
Dec 6
TYS9:40 amKnoxville McGhee Tyson
8h 49m
2 stops
OMA5:29 pmOmaha Eppley Airfield
$282
Find similar
United Airlines
Feb 14
OMA11:30 amOmaha Eppley Airfield
6h 59m
2 stops
TYS7:29 pmKnoxville McGhee Tyson
Feb 21
TYS2:21 pmKnoxville McGhee Tyson
8h 46m
2 stops
OMA10:07 pmOmaha Eppley Airfield
$297
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 10, 2025.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Sat 2/21

5:00 pm-11:50 pm

1 stop5h 50m

Knoxville McGhee Tyson

Wed 2/25

12:00 pm-4:20 pm

1 stop5h 20m

$249

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 12/4

2:56 pm-8:33 am

1 stop16h 37m

Knoxville McGhee Tyson

Sun 12/7

4:52 pm-7:03 pm

1 stop27h 11m

$256

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Fri 4/3

1:10 pm-8:46 pm

1 stop6h 36m

Knoxville McGhee Tyson

Sun 4/5

7:00 am-12:04 pm

1 stop6h 04m

$266

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 12/2

8:00 am-1:17 pm

1 stop4h 17m

Knoxville McGhee Tyson

Sat 12/6

9:40 am-5:29 pm

2 stops8h 49m

$282

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Mon 11/24

2:50 pm-10:51 pm

1 stop7h 01m

Knoxville McGhee Tyson

Fri 11/28

6:30 am-1:32 pm

1 stop8h 02m

$294

MolineKnoxville

MLI - TYS

MLITYS

Moline Quad-City

Thu 12/11

10:09 am-4:33 pm

1 stop5h 24m

Knoxville McGhee Tyson

Mon 12/15

8:20 am-6:23 pm

1 stop11h 03m

$301

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Fri 1/23

7:30 am-10:21 pm

1 stop13h 51m

Knoxville McGhee Tyson

Sun 1/25

2:00 pm-11:07 pm

1 stop10h 07m

$301

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 12/2

2:07 pm-10:51 pm

2 stops7h 44m

Knoxville McGhee Tyson

Sat 12/6

5:05 am-1:37 pm

2 stops9h 32m

$308

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 4/14

5:30 am-5:05 pm

2 stops10h 35m

Knoxville McGhee Tyson

Mon 4/20

6:35 am-4:10 pm

1 stop10h 35m

$358

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 4/4

5:20 am-1:10 pm

2 stops6h 50m

Knoxville McGhee Tyson

Sat 4/11

6:40 am-1:30 pm

2 stops7h 50m

$363

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Iowa to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from Iowa, with most prices found around $246. If you aren’t able to travel during the month of November, then book flights to Knoxville from Iowa during January instead. Flights to Knoxville in January, while not as cheap as those in November, still average around $253.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Iowa to Knoxville is on a Saturday. Travelers who choose to depart for Knoxville on a Saturday will often find tickets for as low as $283. When flying out on a Monday, the most expensive travel day of the week, you can expect to see flight prices from Iowa to Knoxville for around $456.

What is the cheapest time of day to depart on your flight to Knoxville?

At noon is the cheapest time of day to fly from Iowa to Knoxville when you can find flight prices for as low as $322. Flying to Knoxville at noon is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $368.

Can stopping save me money on Iowa to Knoxville flights?

You could potentially save up to 77% on your flight if you consider stops on a Iowa to Knoxville flight.

Cheap Iowa to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Knoxville

Direct flights

None
There are no direct flights from Iowa to Knoxville. There are no popular flight routes from Iowa to Knoxville.
Search flight deals

  • When did momondo last update prices for flights from Iowa to Knoxville McGhee Tyson Airport?

    Prices for flights from Iowa to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Iowa to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Iowa to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Knoxville

Compare and see reviews for airlines that fly from Iowa to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $203Free CancellationRating
7.9
8,004 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
11,047 reviews
Search American Airlines flights
United AirlinesPriceFrom $294Free CancellationRating
7.4
9,012 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Knoxville?

It is quick and easy to find Iowa to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Iowa to Knoxville with flexible booking policies on momondo?

All flight searches from Iowa to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Knoxville?

Once you have performed a search for Iowa to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Iowa to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Iowa to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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