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Cheap flights from Iowa to Knoxville from $134

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Knoxville departing on 8/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Iowa to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
5:40 am - 11:11 am
DSM
-
TYS
4h 31m
1 stop
Delta Logo
7:30 am - 10:43 am
TYS
-
DSM
4h 13m
1 stop
$279Delta
Thu, Aug 13 - Sat, Aug 22
Delta Logo
5:39 pm - 11:00 pm
OMA
-
TYS
4h 21m
1 stop
Delta Logo
12:01 pm - 5:20 pm
TYS
-
OMA
6h 19m
1 stop
$279Delta
Mon, Aug 17 - Thu, Aug 20
Multiple Airlines Logo
6:24 pm - 4:13 pm
CID
-
TYS
20h 49m
1 stop
Multiple Airlines Logo
7:00 am - 2:06 pm
TYS
-
CID
8h 06m
1 stop
$281Multiple Airlines
Fri, Aug 14 - Sun, Aug 16
United Airlines Logo
6:15 am - 1:20 pm
OMA
-
TYS
6h 05m
1 stop
United Airlines Logo
5:45 am - 12:20 pm
TYS
-
OMA
7h 35m
2 stops
$284United Airlines
Mon, Aug 17 - Thu, Aug 20
Multiple Airlines Logo
5:12 pm - 10:24 pm
DSM
-
TYS
28h 12m
1 stop
Multiple Airlines Logo
2:39 pm - 6:48 pm
TYS
-
DSM
29h 09m
2 stops
$284Multiple Airlines
Thu, Aug 13 - Thu, Aug 20
Allegiant Air Logo
1:55 pm - 6:35 pm
DSM
-
TYS
27h 40m
1 stop
Allegiant Air Logo
1:21 pm - 4:38 pm
TYS
-
DSM
28h 17m
1 stop
$286Allegiant Air
Sun, Aug 23 - Sun, Aug 30
United Airlines Logo
1:55 pm - 10:29 pm
OMA
-
TYS
7h 34m
1 stop
United Airlines Logo
10:40 am - 2:04 pm
TYS
-
OMA
4h 24m
1 stop
$287United Airlines
Wed, Aug 26 - Sat, Aug 29
Allegiant Air Logo
5:12 pm - 10:24 pm
DSM
-
TYS
28h 12m
1 stop
Allegiant Air Logo
2:56 pm - 9:31 pm
TYS
-
DSM
7h 35m
1 stop
$289Allegiant Air
Thu, Aug 13 - Sun, Aug 16
Southwest Logo
6:10 am - 2:20 pm
DSM
-
TYS
7h 10m
2 stops
Southwest Logo
6:50 am - 2:10 pm
TYS
-
DSM
8h 20m
2 stops
$297Southwest
Tue, Aug 25 - Sat, Aug 29
Southwest Logo
5:45 am - 4:40 pm
OMA
-
TYS
9h 55m
2 stops
Southwest Logo
7:10 am - 5:30 pm
TYS
-
OMA
11h 20m
2 stops
$303Southwest
Tue, Nov 3 - Sat, Nov 7

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Southwest flights from Iowa to Knoxville

Our best Southwest deals on Iowa to Knoxville flight tickets
Southwest
Aug 25
DSM6:10 amDes Moines
7h 10m
2 stops
TYS2:20 pmKnoxville McGhee Tyson
Aug 29
TYS6:50 amKnoxville McGhee Tyson
8h 20m
2 stops
DSM2:10 pmDes Moines
$297
Southwest
Nov 3
OMA5:45 amOmaha Eppley Airfield
9h 55m
2 stops
TYS4:40 pmKnoxville McGhee Tyson
Nov 7
TYS7:10 amKnoxville McGhee Tyson
11h 20m
2 stops
OMA5:30 pmOmaha Eppley Airfield
$303
Southwest
Sep 22
OMA10:30 amOmaha Eppley Airfield
7h 30m
2 stops
TYS7:00 pmKnoxville McGhee Tyson
Sep 23
TYS8:05 amKnoxville McGhee Tyson
9h 00m
2 stops
OMA4:05 pmOmaha Eppley Airfield
$319

American Airlines flights from Iowa to Knoxville

Our best American Airlines deals on Iowa to Knoxville flight tickets
American Airlines
Aug 18
OMA1:54 pmOmaha Eppley Airfield
8h 04m
2 stops
TYS10:58 pmKnoxville McGhee Tyson
Aug 24
TYS6:05 pmKnoxville McGhee Tyson
7h 05m
2 stops
OMA12:10 amOmaha Eppley Airfield
$297
American Airlines
Sep 21
DSM4:14 pmDes Moines
6h 08m
1 stop
TYS11:22 pmKnoxville McGhee Tyson
Sep 28
TYS8:15 pmKnoxville McGhee Tyson
4h 49m
1 stop
DSM12:04 amDes Moines
$308
American Airlines
Sep 2
CID12:57 pmCedar Rapids
5h 04m
1 stop
TYS7:01 pmKnoxville McGhee Tyson
Sep 6
TYS1:02 pmKnoxville McGhee Tyson
7h 12m
1 stop
CID7:14 pmCedar Rapids
$312

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 8/13

5:40 am-11:11 am

1 stop4h 31m

Knoxville McGhee Tyson

Sat 8/22

7:30 am-10:43 am

1 stop4h 13m

$279

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Mon 8/17

5:39 pm-11:00 pm

1 stop4h 21m

Knoxville McGhee Tyson

Thu 8/20

12:01 pm-5:20 pm

1 stop6h 19m

$279

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Fri 8/14

6:24 pm-4:13 pm

1 stop20h 49m

Knoxville McGhee Tyson

Sun 8/16

7:00 am-2:06 pm

1 stop8h 06m

$281

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Mon 8/17

6:15 am-1:20 pm

1 stop6h 05m

Knoxville McGhee Tyson

Thu 8/20

5:45 am-12:20 pm

2 stops7h 35m

$284

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 8/13

5:12 pm-10:24 pm

1 stop28h 12m

Knoxville McGhee Tyson

Thu 8/20

2:39 pm-6:48 pm

2 stops29h 09m

$284

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sun 8/23

1:55 pm-6:35 pm

1 stop27h 40m

Knoxville McGhee Tyson

Sun 8/30

1:21 pm-4:38 pm

1 stop28h 17m

$286

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Wed 8/26

1:55 pm-10:29 pm

1 stop7h 34m

Knoxville McGhee Tyson

Sat 8/29

10:40 am-2:04 pm

1 stop4h 24m

$287

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 8/13

5:12 pm-10:24 pm

1 stop28h 12m

Knoxville McGhee Tyson

Sun 8/16

2:56 pm-9:31 pm

1 stop7h 35m

$289

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/25

6:10 am-2:20 pm

2 stops7h 10m

Knoxville McGhee Tyson

Sat 8/29

6:50 am-2:10 pm

2 stops8h 20m

$297

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 11/3

5:45 am-4:40 pm

2 stops9h 55m

Knoxville McGhee Tyson

Sat 11/7

7:10 am-5:30 pm

2 stops11h 20m

$303

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Iowa to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of January is, on average, the cheapest month to fly to Knoxville from Iowa, with most prices found around $265. If you aren’t able to travel during the month of January, then book flights to Knoxville from Iowa during March instead. Flights to Knoxville in March, while not as cheap as those in January, still average around $326.

Cheap Iowa to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Knoxville

Fastest flight time

3h 54m

Direct flights

None
The fastest flight from Iowa to Knoxville takes 3h 54m
There are no direct flights from Iowa to Knoxville. There are no popular flight routes from Iowa to Knoxville.
Search flight deals

Frequently asked questions about flying from Iowa to Knoxville

  • When did momondo last update prices for flights from Iowa to Knoxville McGhee Tyson Airport?

    Prices for flights from Iowa to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Iowa to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Iowa to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Knoxville

Compare and see reviews for airlines that fly from Iowa to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.1
11,836 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.8
8,482 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
10,041 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Knoxville?

It is quick and easy to find Iowa to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Iowa to Knoxville with flexible booking policies on momondo?

All flight searches from Iowa to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Knoxville?

Once you have performed a search for Iowa to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Iowa to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Iowa to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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