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Cheap flights from Iowa to Knoxville from $129

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Iowa to Knoxville departing on 6/20. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Iowa to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
1:37 pm - 10:48 pm
DSM
-
TYS
8h 11m
1 stop
Allegiant Air Logo
3:38 pm - 9:27 pm
TYS
-
DSM
6h 49m
1 stop
$213Allegiant Air
Mon, Jul 13 - Thu, Jul 16
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
3:38 pm - 10:47 pm
TYS
-
DSM
8h 09m
1 stop
$219Allegiant Air
Thu, Jul 16 - Sun, Jul 19
Multiple Airlines Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Multiple Airlines Logo
12:56 pm - 11:19 pm
TYS
-
DSM
35h 23m
2 stops
$245Multiple Airlines
Thu, Jul 30 - Wed, Aug 5
Frontier Logo
3:01 pm - 7:24 pm
CID
-
TYS
27h 23m
1 stop
Frontier Logo
8:19 pm - 2:06 pm
TYS
-
CID
18h 47m
1 stop
$256Frontier
Tue, Aug 4 - Mon, Aug 10
Frontier Logo
3:01 pm - 7:24 pm
CID
-
TYS
27h 23m
1 stop
Frontier Logo
8:19 pm - 1:10 pm
TYS
-
CID
17h 51m
1 stop
$276Frontier
Sun, Aug 9 - Mon, Aug 17
American Airlines Logo
5:00 am - 11:05 am
DSM
-
TYS
5h 05m
1 stop
American Airlines Logo
6:52 pm - 12:20 am
TYS
-
DSM
6h 28m
1 stop
$295American Airlines
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
7:13 am - 2:15 pm
CID
-
TYS
6h 02m
1 stop
American Airlines Logo
6:19 pm - 12:02 am
TYS
-
CID
6h 43m
1 stop
$295American Airlines
Wed, Sep 9 - Sat, Sep 12
Southwest Logo
3:15 pm - 8:25 pm
OMA
-
TYS
4h 10m
1 stop
Southwest Logo
5:40 pm - 10:40 pm
TYS
-
OMA
6h 00m
1 stop
$295Southwest
Tue, Jul 7 - Tue, Jul 14
Multiple Airlines Logo
8:15 pm - 11:59 am
OMA
-
TYS
38h 44m
2 stops
Multiple Airlines Logo
10:03 pm - 11:07 am
TYS
-
OMA
14h 04m
1 stop
$300Multiple Airlines
Wed, Jun 24 - Mon, Jun 29
Southwest Logo
10:35 am - 8:25 pm
OMA
-
TYS
8h 50m
2 stops
Southwest Logo
12:45 pm - 10:35 pm
TYS
-
OMA
10h 50m
2 stops
$305Southwest
Tue, Jul 7 - Tue, Jul 14

American Airlines flights from Iowa to Knoxville

Our best American Airlines deals on Iowa to Knoxville flight tickets
American Airlines
Aug 4
DSM5:00 amDes Moines
5h 05m
1 stop
TYS11:05 amKnoxville McGhee Tyson
Aug 11
TYS6:52 pmKnoxville McGhee Tyson
6h 28m
1 stop
DSM12:20 amDes Moines
$295
American Airlines
Sep 9
CID5:00 amCedar Rapids
7h 33m
2 stops
TYS1:33 pmKnoxville McGhee Tyson
Sep 12
TYS5:35 pmKnoxville McGhee Tyson
7h 03m
1 stop
CID11:38 pmCedar Rapids
$300
American Airlines
Jul 9
OMA5:05 pmOmaha Eppley Airfield
5h 46m
1 stop
TYS11:51 pmKnoxville McGhee Tyson
Jul 14
TYS5:37 amKnoxville McGhee Tyson
6h 48m
1 stop
OMA11:25 amOmaha Eppley Airfield
$326

Delta flights from Iowa to Knoxville

Our best Delta deals on Iowa to Knoxville flight tickets
Delta
Aug 23
CID6:00 amCedar Rapids
4h 11m
1 stop
TYS11:11 amKnoxville McGhee Tyson
Aug 29
TYS6:30 amKnoxville McGhee Tyson
5h 50m
1 stop
CID11:20 amCedar Rapids
$302
Delta
Jun 17
CID5:45 amCedar Rapids
4h 24m
1 stop
TYS11:09 amKnoxville McGhee Tyson
Jun 24
TYS7:15 amKnoxville McGhee Tyson
9h 24m
2 stops
CID3:39 pmCedar Rapids
$307
Delta
Oct 12
CID5:30 pmCedar Rapids
4h 32m
1 stop
TYS11:02 pmKnoxville McGhee Tyson
Oct 18
TYS5:57 pmKnoxville McGhee Tyson
4h 54m
1 stop
CID9:51 pmCedar Rapids
$309

momondo Fare Finder

 
Customize your flight search to find flights from Iowa to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 26, 2026.
Use the filters below to find and compare flights from Iowa to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 7/13

1:37 pm-10:48 pm

1 stop8h 11m

Knoxville McGhee Tyson

Thu 7/16

3:38 pm-9:27 pm

1 stop6h 49m

$213

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/16

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Sun 7/19

3:38 pm-10:47 pm

1 stop8h 09m

$219

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 7/30

5:08 pm-10:00 pm

1 stop27h 52m

Knoxville McGhee Tyson

Wed 8/5

12:56 pm-11:19 pm

2 stops35h 23m

$245

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Tue 8/4

3:01 pm-7:24 pm

1 stop27h 23m

Knoxville McGhee Tyson

Mon 8/10

8:19 pm-2:06 pm

1 stop18h 47m

$256

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Sun 8/9

3:01 pm-7:24 pm

1 stop27h 23m

Knoxville McGhee Tyson

Mon 8/17

8:19 pm-1:10 pm

1 stop17h 51m

$276

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 8/4

5:00 am-11:05 am

1 stop5h 05m

Knoxville McGhee Tyson

Tue 8/11

6:52 pm-12:20 am

1 stop6h 28m

$295

Cedar RapidsKnoxville

CID - TYS

CIDTYS

Cedar Rapids

Wed 9/9

7:13 am-2:15 pm

1 stop6h 02m

Knoxville McGhee Tyson

Sat 9/12

6:19 pm-12:02 am

1 stop6h 43m

$295
Quickest round-trip

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 7/7

3:15 pm-8:25 pm

1 stop4h 10m

Knoxville McGhee Tyson

Tue 7/14

5:40 pm-10:40 pm

1 stop6h 00m

$295

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Wed 6/24

8:15 pm-11:59 am

2 stops38h 44m

Knoxville McGhee Tyson

Mon 6/29

10:03 pm-11:07 am

1 stop14h 04m

$300

OmahaKnoxville

OMA - TYS

OMATYS

Omaha Eppley Airfield

Tue 7/7

10:35 am-8:25 pm

2 stops8h 50m

Knoxville McGhee Tyson

Tue 7/14

12:45 pm-10:35 pm

2 stops10h 50m

$305

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Iowa to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Knoxville?

The month of November is, on average, the cheapest month to fly to Knoxville from Iowa, with most prices found around $203. If you aren’t able to travel during the month of November, then book flights to Knoxville from Iowa during December instead. Flights to Knoxville in December, while not as cheap as those in November, still average around $248.

Cheap Iowa to Knoxville flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Iowa to Knoxville

Fastest flight time

4h 04m

Direct flights

None
The fastest flight from Iowa to Knoxville takes 4h 04m
There are no direct flights from Iowa to Knoxville. There are no popular flight routes from Iowa to Knoxville.
Search flight deals

Frequently asked questions about flying from Iowa to Knoxville

  • When did momondo last update prices for flights from Iowa to Knoxville McGhee Tyson Airport?

    Prices for flights from Iowa to Knoxville McGhee Tyson Airport are updated daily.

  • How many operators does momondo search for flights from Iowa to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Iowa to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Iowa to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents you'll need for your trip to Knoxville McGhee Tyson Airport may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Iowa to Knoxville

Compare and see reviews for airlines that fly from Iowa to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $203Free CancellationRating
7.1
11,629 reviews
Search American Airlines flights
DeltaPriceFrom $203Free CancellationRating
7.9
8,425 reviews
Search Delta flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
9,749 reviews
Search United Airlines flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Iowa to Knoxville?

It is quick and easy to find Iowa to Knoxville flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Knoxville that suits you.

Can I find flights from Iowa to Knoxville with flexible booking policies on momondo?

All flight searches from Iowa to Knoxville on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Iowa to Knoxville?

Once you have performed a search for Iowa to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Iowa to Knoxville right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Iowa to Knoxville now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Knoxville and let you know when they change.

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