Cheap flights from Houston to Knoxville from $45

The month of August is, on average, the cheapest month to fly to Knoxville from Houston, with most prices found around $256. If you aren’t able to travel during the month of August, then book flights to Knoxville from Houston during July instead. Flights to Knoxville in July, while not as cheap as those in August, still average around $279.

The cheapest day to depart from Houston to Knoxville is on a Sunday. Travelers who choose to depart for Knoxville on a Sunday will often find tickets for as low as $85. When flying out on a Wednesday, the most expensive travel day of the week, you can expect to see flight prices from Houston to Knoxville for around $399.

In the evening is the cheapest time of day to fly from Houston to Knoxville when you can find flight prices for as low as $175. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is at noon when prices are around $466.

Fly from Houston Hobby to Knoxville McGhee Tyson for the best Houston - Knoxville McGhee Tyson flight prices

You are more likely to see cheaper flights to Knoxville from Houston when booking weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $266 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Houston for as low as $172 on momondo.

There are 4 cabin classes available to choose from on Houston to Knoxville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Allegiant Air, Southwest, and Frontier are the most popular carriers operating from Houston to Knoxville McGhee Tyson

United Airlines, Delta and American Airlines are the top three most popular airlines that fly to Knoxville from Houston according to our data. United Airlines is the first choice among our users, with 35% of people opting to fly with this airline when traveling to Knoxville. Keep in mind that there are 5 different airlines that fly to Knoxville on a routine basis, so you have a few additional options to choose from.

5 flights are operational daily from Houston to Knoxville as of August 2026. The most popular departure time for this route is 7:00PM, with 39% of flights per day taking off in the evening.

As of August 2026, there are 41 flights per week flying from Houston to Knoxville. The most common day of the week flights depart is Wed, with 22% of flights taking off on this day.