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Cheap flights from Guayaquil to Knoxville from $288

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Knoxville departing on 3/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Guayaquil to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:59 pm - 10:40 am
GYE
-
TYS
9h 41m
1 stop
Multiple Airlines Logo
7:30 am - 11:04 pm
TYS
-
GYE
16h 34m
1 stop
$359Multiple Airlines
Tue, Mar 24 - Mon, Apr 13
Multiple Airlines Logo
11:59 pm - 8:42 pm
GYE
-
TYS
19h 43m
1 stop
Multiple Airlines Logo
7:30 am - 11:04 pm
TYS
-
GYE
16h 34m
1 stop
$392Multiple Airlines
Wed, Apr 15 - Mon, May 4
Multiple Airlines Logo
11:59 pm - 10:36 am
GYE
-
TYS
9h 37m
1 stop
Multiple Airlines Logo
7:30 am - 11:04 pm
TYS
-
GYE
16h 34m
1 stop
$400Multiple Airlines
Tue, Apr 14 - Mon, May 4
Multiple Airlines Logo
11:59 pm - 12:51 pm
GYE
-
TYS
11h 52m
2 stops
Multiple Airlines Logo
7:30 am - 11:04 pm
TYS
-
GYE
16h 34m
1 stop
$408Multiple Airlines
Tue, Mar 24 - Mon, Apr 13
Multiple Airlines Logo
11:59 pm - 8:42 pm
GYE
-
TYS
19h 43m
1 stop
Multiple Airlines Logo
1:15 pm - 11:04 pm
TYS
-
GYE
34h 49m
2 stops
$414Multiple Airlines
Wed, Apr 15 - Mon, May 4
Multiple Airlines Logo
11:59 pm - 10:36 am
GYE
-
TYS
9h 37m
1 stop
Multiple Airlines Logo
1:15 pm - 11:04 pm
TYS
-
GYE
34h 49m
2 stops
$422Multiple Airlines
Tue, Apr 14 - Mon, May 4
Multiple Airlines Logo
11:59 pm - 10:36 am
GYE
-
TYS
9h 37m
1 stop
Multiple Airlines Logo
8:00 am - 11:04 pm
TYS
-
GYE
40h 04m
2 stops
$430Multiple Airlines
Tue, Apr 14 - Tue, Apr 21
Multiple Airlines Logo
4:05 am - 10:36 am
GYE
-
TYS
29h 31m
2 stops
Multiple Airlines Logo
7:30 am - 11:04 pm
TYS
-
GYE
16h 34m
1 stop
$435Multiple Airlines
Tue, Apr 7 - Mon, Apr 20
Multiple Airlines Logo
6:50 pm - 10:05 pm
GYE
-
TYS
26h 15m
2 stops
Multiple Airlines Logo
7:30 am - 11:04 pm
TYS
-
GYE
16h 34m
1 stop
$445Multiple Airlines
Wed, Apr 8 - Mon, Apr 20
Multiple Airlines Logo
11:59 pm - 12:25 pm
GYE
-
TYS
11h 26m
1 stop
Multiple Airlines Logo
9:32 pm - 11:04 pm
TYS
-
GYE
26h 32m
1 stop
$453Multiple Airlines
Thu, Apr 23 - Sun, Apr 26

American Airlines flights from Guayaquil to Knoxville

Our best American Airlines deals on Guayaquil to Knoxville flight tickets
American Airlines
Apr 14
GYE6:05 amGuayaquil Jose Joaquin de Olmedo
16h 54m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Apr 28
TYS6:30 amKnoxville McGhee Tyson
15h 42m
1 stop
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
$667
American Airlines
Apr 15
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
8h 28m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Apr 28
TYS6:30 amKnoxville McGhee Tyson
8h 01m
1 stop
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
$671
American Airlines
May 3
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
20h 59m
2 stops
TYS12:30 pmKnoxville McGhee Tyson
May 19
TYS7:04 amKnoxville McGhee Tyson
15h 08m
2 stops
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
$672

Copa Airlines flights from Guayaquil to Knoxville

Our best Copa Airlines deals on Guayaquil to Knoxville flight tickets
Copa Airlines
Mar 3
GYE2:35 pmGuayaquil Jose Joaquin de Olmedo
19h 37m
2 stops
TYS10:12 amKnoxville McGhee Tyson
Mar 17
TYS7:25 pmKnoxville McGhee Tyson
16h 53m
2 stops
GYE11:18 amGuayaquil Jose Joaquin de Olmedo
$784
Copa Airlines
Feb 27
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
21h 59m
2 stops
TYS10:19 amKnoxville McGhee Tyson
May 8
TYS8:30 pmKnoxville McGhee Tyson
25h 22m
2 stops
GYE8:52 pmGuayaquil Jose Joaquin de Olmedo
$961

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 20, 2026.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 3/24

11:59 pm-10:40 am

1 stop9h 41m

Knoxville McGhee Tyson

Mon 4/13

7:30 am-11:04 pm

1 stop16h 34m

$359

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 4/15

11:59 pm-8:42 pm

1 stop19h 43m

Knoxville McGhee Tyson

Mon 5/4

7:30 am-11:04 pm

1 stop16h 34m

$392

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 4/14

11:59 pm-10:36 am

1 stop9h 37m

Knoxville McGhee Tyson

Mon 5/4

7:30 am-11:04 pm

1 stop16h 34m

$400

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 3/24

11:59 pm-12:51 pm

2 stops11h 52m

Knoxville McGhee Tyson

Mon 4/13

7:30 am-11:04 pm

1 stop16h 34m

$408

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 4/15

11:59 pm-8:42 pm

1 stop19h 43m

Knoxville McGhee Tyson

Mon 5/4

1:15 pm-11:04 pm

2 stops34h 49m

$414

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 4/14

11:59 pm-10:36 am

1 stop9h 37m

Knoxville McGhee Tyson

Mon 5/4

1:15 pm-11:04 pm

2 stops34h 49m

$422

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 4/14

11:59 pm-10:36 am

1 stop9h 37m

Knoxville McGhee Tyson

Tue 4/21

8:00 am-11:04 pm

2 stops40h 04m

$430

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 4/7

4:05 am-10:36 am

2 stops29h 31m

Knoxville McGhee Tyson

Mon 4/20

7:30 am-11:04 pm

1 stop16h 34m

$435

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 4/8

6:50 pm-10:05 pm

2 stops26h 15m

Knoxville McGhee Tyson

Mon 4/20

7:30 am-11:04 pm

1 stop16h 34m

$445

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 4/23

11:59 pm-12:25 pm

1 stop11h 26m

Knoxville McGhee Tyson

Sun 4/26

9:32 pm-11:04 pm

1 stop26h 32m

$453

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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When to book flights from Guayaquil to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Knoxville (GYE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Knoxville

Fastest flight time

12h 58m

Direct flights

None
The fastest flight from Guayaquil to Knoxville takes 12h 58m
There are no direct flights from Guayaquil to Knoxville. There are no popular flight routes from Guayaquil to Knoxville.
Search flight deals

  • How far is Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 2647.2 mi away from Guayaquil Jose Joaquin de Olmedo. In terms of flight time, this usually takes a little over 12h 58m.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Guayaquil to Knoxville?

Best airlines flying from Guayaquil to Knoxville

Compare and see reviews for airlines that fly from Guayaquil to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $743Free CancellationRating
7.9
8,215 reviews
Search Delta flights
American AirlinesPriceFrom $799Free CancellationRating
7.2
11,320 reviews
Search American Airlines flights

  • How do I get Price Alerts for flights from Guayaquil to Knoxville?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Guayaquil from Knoxville. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Guayaquil to Knoxville with momondo?

    With “Price Forecast”, learn how soon you should book your flight in advance. Down to the day of week and time of day, our information can inform you on the ideal time to book to save on your travel. Our “Price Calendar” shows you at a quick glance when to book your travel for lower rates. By setting “Price Alerts” you can monitor changes in price and target the ideal time to book. Search for your trip destination by budget amount via our “Explore” feature. Whether you’re looking for ideas for your next travel adventure or cost-cutting tips, our “Discover” content is a great place to start.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Crossville
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Knoxville?

Finding the right flight to Knoxville from Guayaquil is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Guayaquil to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Guayaquil on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Guayaquil to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Guayaquil.

I’m not ready to book a flight from Guayaquil to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Guayaquil are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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