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Cheap flights from Guayaquil to Knoxville from $227

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Knoxville departing on 11/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Guayaquil to Knoxville

Cheap round-trip flights

United Airlines Logo
12:20 pm - 7:34 pmGYE-TYS
31h 14m2 stops
United Airlines Logo
9:15 am - 11:18 amTYS-GYE
27h 03m2 stops
$596United Airlines
Find Deal
Mon, Feb 16 - Thu, May 7
Multiple Airlines Logo
4:40 am - 11:44 pmGYE-TYS
19h 04m2 stops
Multiple Airlines Logo
9:15 am - 10:25 amTYS-GYE
25h 10m2 stops
$613Multiple Airlines
Find Deal
Mon, Feb 2 - Tue, Feb 17
American Airlines Logo
2:33 pm - 5:35 pmGYE-TYS
27h 02m1 stop
American Airlines Logo
7:04 am - 1:33 pmTYS-GYE
7h 29m1 stop
$702American Airlines
Find Deal
Wed, Feb 18 - Wed, Apr 1
American Airlines Logo
2:33 pm - 5:35 pmGYE-TYS
27h 02m1 stop
American Airlines Logo
7:04 am - 1:33 pmTYS-GYE
7h 29m1 stop
$704American Airlines
Find Deal
Wed, Feb 18 - Wed, Apr 1
American Airlines Logo
2:33 pm - 12:16 pmGYE-TYS
21h 43m2 stops
American Airlines Logo
6:58 am - 9:00 pmTYS-GYE
15h 02m2 stops
$706American Airlines
Find Deal
Wed, Feb 18 - Wed, Apr 1
American Airlines Logo
2:33 pm - 8:27 amGYE-TYS
17h 54m2 stops
American Airlines Logo
8:15 am - 9:00 pmTYS-GYE
13h 45m2 stops
$708American Airlines
Find Deal
Wed, Feb 18 - Wed, Apr 1
American Airlines Logo
7:30 am - 10:30 amGYE-TYS
27h 00m2 stops
American Airlines Logo
6:16 pm - 1:33 pmTYS-GYE
19h 17m2 stops
$711American Airlines
Find Deal
Mon, Feb 2 - Mon, Feb 16
United Airlines Logo
12:21 pm - 11:44 pmGYE-TYS
35h 23m2 stops
United Airlines Logo
11:42 am - 11:18 amTYS-GYE
23h 36m2 stops
$779United Airlines
Find Deal
Sat, Nov 8 - Wed, Dec 10
Avianca Logo
4:40 am - 10:49 amGYE-TYS
30h 09m2 stops
Avianca Logo
5:50 am - 1:40 pmTYS-GYE
32h 50m2 stops
$1,001Avianca
Find Deal
Sun, Feb 15 - Thu, May 7
Avianca Logo
3:30 am - 7:29 pmGYE-TYS
15h 59m2 stops
Avianca Logo
5:50 am - 10:40 pmTYS-GYE
17h 50m2 stops
$3,379Avianca
Find Deal
Tue, Feb 17 - Wed, Apr 1

American Airlines flights from Guayaquil to Knoxville

Our best American Airlines deals on Guayaquil to Knoxville flight tickets
American Airlines
Feb 18
GYE2:33 pmGuayaquil Jose Joaquin de Olmedo
27h 02m
1 stop
TYS5:35 pmKnoxville McGhee Tyson
Apr 1
TYS7:04 amKnoxville McGhee Tyson
7h 29m
1 stop
GYE1:33 pmGuayaquil Jose Joaquin de Olmedo
$702
Find similar
American Airlines
Feb 18
GYE2:33 pmGuayaquil Jose Joaquin de Olmedo
27h 02m
1 stop
TYS5:35 pmKnoxville McGhee Tyson
Apr 1
TYS7:04 amKnoxville McGhee Tyson
7h 29m
1 stop
GYE1:33 pmGuayaquil Jose Joaquin de Olmedo
$704
Find similar
American Airlines
Feb 18
GYE2:33 pmGuayaquil Jose Joaquin de Olmedo
21h 43m
2 stops
TYS12:16 pmKnoxville McGhee Tyson
Apr 1
TYS6:58 amKnoxville McGhee Tyson
15h 02m
2 stops
GYE9:00 pmGuayaquil Jose Joaquin de Olmedo
$706
Find similar

United Airlines flights from Guayaquil to Knoxville

Our best United Airlines deals on Guayaquil to Knoxville flight tickets
United Airlines
Feb 16
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
31h 14m
2 stops
TYS7:34 pmKnoxville McGhee Tyson
May 7
TYS9:15 amKnoxville McGhee Tyson
27h 03m
2 stops
GYE11:18 amGuayaquil Jose Joaquin de Olmedo
$596
Find similar
United Airlines
Nov 8
GYE12:21 pmGuayaquil Jose Joaquin de Olmedo
35h 23m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Dec 10
TYS11:42 amKnoxville McGhee Tyson
23h 36m
2 stops
GYE11:18 amGuayaquil Jose Joaquin de Olmedo
$779
Find similar
United Airlines
Nov 8
GYE8:30 amGuayaquil Jose Joaquin de Olmedo
35h 39m
2 stops
TYS8:09 pmKnoxville McGhee Tyson
Dec 10
TYS11:42 amKnoxville McGhee Tyson
25h 52m
2 stops
GYE1:34 pmGuayaquil Jose Joaquin de Olmedo
$804
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 23, 2025.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

12:20 pm-7:34 pm

2 stops31h 14m

Knoxville McGhee Tyson

Thu 5/7

9:15 am-11:18 am

2 stops27h 03m

$596

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/2

4:40 am-11:44 pm

2 stops19h 04m

Knoxville McGhee Tyson

Tue 2/17

9:15 am-10:25 am

2 stops25h 10m

$613

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

2:33 pm-5:35 pm

1 stop27h 02m

Knoxville McGhee Tyson

Wed 4/1

7:04 am-1:33 pm

1 stop7h 29m

$702

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

2:33 pm-5:35 pm

1 stop27h 02m

Knoxville McGhee Tyson

Wed 4/1

7:04 am-1:33 pm

1 stop7h 29m

$704

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

2:33 pm-12:16 pm

2 stops21h 43m

Knoxville McGhee Tyson

Wed 4/1

6:58 am-9:00 pm

2 stops15h 02m

$706

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

2:33 pm-8:27 am

2 stops17h 54m

Knoxville McGhee Tyson

Wed 4/1

8:15 am-9:00 pm

2 stops13h 45m

$708

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/2

7:30 am-10:30 am

2 stops27h 00m

Knoxville McGhee Tyson

Mon 2/16

6:16 pm-1:33 pm

2 stops19h 17m

$711

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 11/8

12:21 pm-11:44 pm

2 stops35h 23m

Knoxville McGhee Tyson

Wed 12/10

11:42 am-11:18 am

2 stops23h 36m

$779

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 2/15

4:40 am-10:49 am

2 stops30h 09m

Knoxville McGhee Tyson

Thu 5/7

5:50 am-1:40 pm

2 stops32h 50m

$1,001

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 2/17

3:30 am-7:29 pm

2 stops15h 59m

Knoxville McGhee Tyson

Wed 4/1

5:50 am-10:40 pm

2 stops17h 50m

$3,379

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Knoxville from

How to get the cheapest flight ticket from Guayaquil to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Guayaquil to Knoxville is on a Monday. Travelers who choose to depart for Knoxville on a Monday will often find tickets for as low as $671. When flying out on a Wednesday, the most expensive travel day of the week, you can expect to see flight prices from Guayaquil to Knoxville for around $777.

When to book flights from Guayaquil to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Knoxville (GYE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Knoxville

Direct flights

None
There are no direct flights from Guayaquil to Knoxville. There are no popular flight routes from Guayaquil to Knoxville.
Search flight deals

  • How far is Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 2647.2 mi away from Guayaquil Jose Joaquin de Olmedo. In terms of flight time, this usually takes a little over 10h 26m.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Guayaquil to Knoxville?

Best airlines flying from Guayaquil to Knoxville

Compare and see reviews for airlines that fly from Guayaquil to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $388Free CancellationRating
7.4
8,926 reviews
Search United Airlines flights
DeltaPriceFrom $743Free CancellationRating
7.9
7,974 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Knoxville?

Finding the right flight to Knoxville from Guayaquil is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Guayaquil to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Guayaquil on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Guayaquil to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Guayaquil.

I’m not ready to book a flight from Guayaquil to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Guayaquil are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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