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Cheap flights from Guayaquil to Knoxville from $791

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Knoxville departing on 9/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Guayaquil to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 8:25 am
GYE
-
TYS
25h 25m
2 stops
American Airlines Logo
7:15 am - 7:00 pm
TYS
-
GYE
12h 45m
2 stops
$791American Airlines
Tue, Sep 8 - Wed, Sep 30
American Airlines Logo
6:00 am - 11:59 pm
GYE
-
TYS
16h 59m
1 stop
American Airlines Logo
5:40 am - 7:00 pm
TYS
-
GYE
14h 20m
1 stop
$797American Airlines
Sun, Jul 12 - Sun, Sep 20
American Airlines Logo
2:25 pm - 10:38 am
GYE
-
TYS
19h 13m
2 stops
American Airlines Logo
8:39 pm - 7:00 pm
TYS
-
GYE
23h 21m
2 stops
$801American Airlines
Sun, Jul 12 - Sun, Sep 20
American Airlines Logo
8:25 am - 11:35 pm
GYE
-
TYS
14h 10m
1 stop
American Airlines Logo
5:07 pm - 2:27 pm
TYS
-
GYE
21h 20m
1 stop
$803American Airlines
Tue, Oct 20 - Sun, Nov 1
American Airlines Logo
2:30 pm - 10:27 am
GYE
-
TYS
18h 57m
2 stops
American Airlines Logo
5:07 pm - 2:27 pm
TYS
-
GYE
21h 20m
1 stop
$807American Airlines
Tue, Oct 20 - Sun, Nov 1
American Airlines Logo
6:00 am - 9:57 pm
GYE
-
TYS
14h 57m
1 stop
American Airlines Logo
5:40 am - 7:00 pm
TYS
-
GYE
14h 20m
1 stop
$824American Airlines
Tue, Sep 8 - Wed, Sep 30
United Airlines Logo
8:28 am - 9:45 pm
GYE
-
TYS
36h 17m
2 stops
United Airlines Logo
7:15 am - 8:52 pm
TYS
-
GYE
14h 37m
2 stops
$832United Airlines
Fri, Sep 18 - Wed, Oct 21
American Airlines Logo
2:31 pm - 10:36 am
GYE
-
TYS
19h 05m
2 stops
American Airlines Logo
6:53 pm - 1:31 pm
TYS
-
GYE
19h 38m
2 stops
$845American Airlines
Tue, Jun 16 - Tue, Jun 23
American Airlines Logo
8:20 am - 11:31 pm
GYE
-
TYS
14h 11m
1 stop
American Airlines Logo
7:13 am - 6:55 pm
TYS
-
GYE
12h 42m
1 stop
$848American Airlines
Mon, Sep 21 - Fri, Oct 23
United Airlines Logo
8:28 am - 12:47 pm
GYE
-
TYS
27h 19m
2 stops
United Airlines Logo
7:15 am - 11:37 pm
TYS
-
GYE
17h 22m
2 stops
$854United Airlines
Mon, Sep 21 - Wed, Oct 21

American Airlines flights from Guayaquil to Knoxville

Our best American Airlines deals on Guayaquil to Knoxville flight tickets
American Airlines
Sep 8
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
25h 25m
2 stops
TYS8:25 amKnoxville McGhee Tyson
Sep 30
TYS7:15 amKnoxville McGhee Tyson
12h 45m
2 stops
GYE7:00 pmGuayaquil Jose Joaquin de Olmedo
$791
American Airlines
Jul 12
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
16h 59m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Sep 20
TYS5:40 amKnoxville McGhee Tyson
14h 20m
1 stop
GYE7:00 pmGuayaquil Jose Joaquin de Olmedo
$797
American Airlines
Jul 12
GYE2:25 pmGuayaquil Jose Joaquin de Olmedo
19h 13m
2 stops
TYS10:38 amKnoxville McGhee Tyson
Sep 20
TYS8:39 pmKnoxville McGhee Tyson
23h 21m
2 stops
GYE7:00 pmGuayaquil Jose Joaquin de Olmedo
$801

United Airlines flights from Guayaquil to Knoxville

Our best United Airlines deals on Guayaquil to Knoxville flight tickets
United Airlines
Sep 18
GYE8:28 amGuayaquil Jose Joaquin de Olmedo
36h 17m
2 stops
TYS9:45 pmKnoxville McGhee Tyson
Oct 21
TYS7:15 amKnoxville McGhee Tyson
14h 37m
2 stops
GYE8:52 pmGuayaquil Jose Joaquin de Olmedo
$832
United Airlines
Sep 21
GYE8:28 amGuayaquil Jose Joaquin de Olmedo
27h 19m
2 stops
TYS12:47 pmKnoxville McGhee Tyson
Oct 21
TYS7:15 amKnoxville McGhee Tyson
17h 22m
2 stops
GYE11:37 pmGuayaquil Jose Joaquin de Olmedo
$854
United Airlines
Sep 19
GYE8:28 amGuayaquil Jose Joaquin de Olmedo
36h 17m
2 stops
TYS9:45 pmKnoxville McGhee Tyson
Oct 21
TYS7:15 amKnoxville McGhee Tyson
11h 15m
2 stops
GYE5:30 pmGuayaquil Jose Joaquin de Olmedo
$873

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 23, 2026.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 9/8

6:00 am-8:25 am

2 stops25h 25m

Knoxville McGhee Tyson

Wed 9/30

7:15 am-7:00 pm

2 stops12h 45m

$791

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 7/12

6:00 am-11:59 pm

1 stop16h 59m

Knoxville McGhee Tyson

Sun 9/20

5:40 am-7:00 pm

1 stop14h 20m

$797

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 7/12

2:25 pm-10:38 am

2 stops19h 13m

Knoxville McGhee Tyson

Sun 9/20

8:39 pm-7:00 pm

2 stops23h 21m

$801

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 10/20

8:25 am-11:35 pm

1 stop14h 10m

Knoxville McGhee Tyson

Sun 11/1

5:07 pm-2:27 pm

1 stop21h 20m

$803

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 10/20

2:30 pm-10:27 am

2 stops18h 57m

Knoxville McGhee Tyson

Sun 11/1

5:07 pm-2:27 pm

1 stop21h 20m

$807

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 9/8

6:00 am-9:57 pm

1 stop14h 57m

Knoxville McGhee Tyson

Wed 9/30

5:40 am-7:00 pm

1 stop14h 20m

$824

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 9/18

8:28 am-9:45 pm

2 stops36h 17m

Knoxville McGhee Tyson

Wed 10/21

7:15 am-8:52 pm

2 stops14h 37m

$832

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 6/16

2:31 pm-10:36 am

2 stops19h 05m

Knoxville McGhee Tyson

Tue 6/23

6:53 pm-1:31 pm

2 stops19h 38m

$845
Quickest round-trip

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 9/21

8:20 am-11:31 pm

1 stop14h 11m

Knoxville McGhee Tyson

Fri 10/23

7:13 am-6:55 pm

1 stop12h 42m

$848

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 9/21

8:28 am-12:47 pm

2 stops27h 19m

Knoxville McGhee Tyson

Wed 10/21

7:15 am-11:37 pm

2 stops17h 22m

$854

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Guayaquil to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Knoxville (GYE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Knoxville

Fastest flight time

25h 05m

Direct flights

None
The fastest flight from Guayaquil to Knoxville takes 25h 05m
There are no direct flights from Guayaquil to Knoxville. There are no popular flight routes from Guayaquil to Knoxville.
Search flight deals

Frequently asked questions about flying from Guayaquil to Knoxville

  • How far is Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 2647.2 mi away from Guayaquil Jose Joaquin de Olmedo. In terms of flight time, this usually takes a little over 25h 05m.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Guayaquil to Knoxville?

Best airlines flying from Guayaquil to Knoxville

Compare and see reviews for airlines that fly from Guayaquil to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $743Free CancellationRating
7.9
8,444 reviews
Search Delta flights
American AirlinesPriceFrom $799Free CancellationRating
7.1
11,640 reviews
Search American Airlines flights

Frequently asked questions about flying from Guayaquil to Knoxville

  • How do I get Price Alerts for flights from Guayaquil to Knoxville?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Guayaquil from Knoxville. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Guayaquil to Knoxville with momondo?

    With “Price Forecast”, learn how soon you should book your flight in advance. Down to the day of week and time of day, our information can inform you on the ideal time to book to save on your travel. Our “Price Calendar” shows you at a quick glance when to book your travel for lower rates. By setting “Price Alerts” you can monitor changes in price and target the ideal time to book. Search for your trip destination by budget amount via our “Explore” feature. Whether you’re looking for ideas for your next travel adventure or cost-cutting tips, our “Discover” content is a great place to start.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Alcoa
Maryville
Crossville
Murphy
Oak Ridge
Kodak
Newport
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Knoxville?

Finding the right flight to Knoxville from Guayaquil is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Guayaquil to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Guayaquil on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Guayaquil to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Guayaquil.

I’m not ready to book a flight from Guayaquil to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Guayaquil are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

An easier way to manage your Knoxville trip

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