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Cheap flights from Guayaquil to Knoxville from $581

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Knoxville departing on 5/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Guayaquil to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:59 pm - 11:06 am
GYE
-
TYS
10h 07m
1 stop
Multiple Airlines Logo
1:36 pm - 11:30 pm
TYS
-
GYE
34h 54m
2 stops
$581Multiple Airlines
Fri, May 1 - Fri, Jul 10
American Airlines Logo
2:31 pm - 2:24 pm
GYE
-
TYS
22h 53m
2 stops
American Airlines Logo
10:20 am - 9:12 pm
TYS
-
GYE
11h 52m
2 stops
$789American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
2:31 pm - 12:30 pm
GYE
-
TYS
20h 59m
2 stops
American Airlines Logo
6:30 am - 9:12 pm
TYS
-
GYE
15h 42m
1 stop
$790American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
6:05 am - 11:59 pm
GYE
-
TYS
16h 54m
1 stop
American Airlines Logo
6:30 am - 9:12 pm
TYS
-
GYE
15h 42m
1 stop
$809American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
2:31 pm - 2:24 pm
GYE
-
TYS
22h 53m
2 stops
American Airlines Logo
6:30 am - 9:12 pm
TYS
-
GYE
15h 42m
1 stop
$813American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
2:31 pm - 11:18 am
GYE
-
TYS
19h 47m
2 stops
American Airlines Logo
7:04 am - 9:12 pm
TYS
-
GYE
15h 08m
2 stops
$814American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
6:05 am - 11:59 pm
GYE
-
TYS
16h 54m
1 stop
American Airlines Logo
6:30 am - 9:12 pm
TYS
-
GYE
15h 42m
1 stop
$819American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
6:05 am - 11:59 pm
GYE
-
TYS
16h 54m
1 stop
American Airlines Logo
6:30 am - 9:12 pm
TYS
-
GYE
15h 42m
1 stop
$852American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
6:05 am - 11:59 pm
GYE
-
TYS
16h 54m
1 stop
American Airlines Logo
6:30 am - 1:31 pm
TYS
-
GYE
8h 01m
1 stop
$877American Airlines
Sun, May 3 - Tue, May 19
American Airlines Logo
2:31 pm - 11:59 pm
GYE
-
TYS
8h 28m
1 stop
American Airlines Logo
6:00 am - 10:37 pm
TYS
-
GYE
17h 37m
1 stop
$882American Airlines
Fri, May 1 - Fri, Jul 10

American Airlines flights from Guayaquil to Knoxville

Our best American Airlines deals on Guayaquil to Knoxville flight tickets
American Airlines
May 3
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
22h 53m
2 stops
TYS2:24 pmKnoxville McGhee Tyson
May 19
TYS10:20 amKnoxville McGhee Tyson
11h 52m
2 stops
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
$789
American Airlines
May 3
GYE2:31 pmGuayaquil Jose Joaquin de Olmedo
20h 59m
2 stops
TYS12:30 pmKnoxville McGhee Tyson
May 19
TYS6:30 amKnoxville McGhee Tyson
15h 42m
1 stop
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
$790
American Airlines
May 3
GYE6:05 amGuayaquil Jose Joaquin de Olmedo
16h 54m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
May 19
TYS6:30 amKnoxville McGhee Tyson
15h 42m
1 stop
GYE9:12 pmGuayaquil Jose Joaquin de Olmedo
$809

United Airlines flights from Guayaquil to Knoxville

Our best United Airlines deals on Guayaquil to Knoxville flight tickets
United Airlines
Apr 13
GYE8:28 amGuayaquil Jose Joaquin de Olmedo
38h 13m
2 stops
TYS11:41 pmKnoxville McGhee Tyson
Apr 28
TYS7:05 amKnoxville McGhee Tyson
11h 26m
2 stops
GYE5:31 pmGuayaquil Jose Joaquin de Olmedo
$946
United Airlines
Apr 13
GYE8:28 amGuayaquil Jose Joaquin de Olmedo
24h 40m
2 stops
TYS10:08 amKnoxville McGhee Tyson
Apr 28
TYS7:05 amKnoxville McGhee Tyson
14h 49m
2 stops
GYE8:54 pmGuayaquil Jose Joaquin de Olmedo
$1,038
United Airlines
Apr 17
GYE12:22 pmGuayaquil Jose Joaquin de Olmedo
30h 34m
2 stops
TYS7:56 pmKnoxville McGhee Tyson
Apr 21
TYS9:00 amKnoxville McGhee Tyson
33h 31m
2 stops
GYE5:31 pmGuayaquil Jose Joaquin de Olmedo
$1,121

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 2, 2026.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 5/1

11:59 pm-11:06 am

1 stop10h 07m

Knoxville McGhee Tyson

Fri 7/10

1:36 pm-11:30 pm

2 stops34h 54m

$581

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

2:31 pm-2:24 pm

2 stops22h 53m

Knoxville McGhee Tyson

Tue 5/19

10:20 am-9:12 pm

2 stops11h 52m

$789

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

2:31 pm-12:30 pm

2 stops20h 59m

Knoxville McGhee Tyson

Tue 5/19

6:30 am-9:12 pm

1 stop15h 42m

$790

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

6:05 am-11:59 pm

1 stop16h 54m

Knoxville McGhee Tyson

Tue 5/19

6:30 am-9:12 pm

1 stop15h 42m

$809

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

2:31 pm-2:24 pm

2 stops22h 53m

Knoxville McGhee Tyson

Tue 5/19

6:30 am-9:12 pm

1 stop15h 42m

$813

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

2:31 pm-11:18 am

2 stops19h 47m

Knoxville McGhee Tyson

Tue 5/19

7:04 am-9:12 pm

2 stops15h 08m

$814

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

6:05 am-11:59 pm

1 stop16h 54m

Knoxville McGhee Tyson

Tue 5/19

6:30 am-9:12 pm

1 stop15h 42m

$819

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

6:05 am-11:59 pm

1 stop16h 54m

Knoxville McGhee Tyson

Tue 5/19

6:30 am-9:12 pm

1 stop15h 42m

$852
Quickest round-trip

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

6:05 am-11:59 pm

1 stop16h 54m

Knoxville McGhee Tyson

Tue 5/19

6:30 am-1:31 pm

1 stop8h 01m

$877

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Fri 5/1

2:31 pm-11:59 pm

1 stop8h 28m

Knoxville McGhee Tyson

Fri 7/10

6:00 am-10:37 pm

1 stop17h 37m

$882

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Guayaquil to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Knoxville (GYE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Knoxville

Fastest flight time

13h 07m

Direct flights

None
The fastest flight from Guayaquil to Knoxville takes 13h 07m
There are no direct flights from Guayaquil to Knoxville. There are no popular flight routes from Guayaquil to Knoxville.
Search flight deals

Frequently asked questions about flying from Guayaquil to Knoxville

  • How far is Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 2647.2 mi away from Guayaquil Jose Joaquin de Olmedo. In terms of flight time, this usually takes a little over 13h 07m.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Guayaquil to Knoxville?

Best airlines flying from Guayaquil to Knoxville

Compare and see reviews for airlines that fly from Guayaquil to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $743Free CancellationRating
7.9
8,370 reviews
Search Delta flights
American AirlinesPriceFrom $799Free CancellationRating
7.1
11,549 reviews
Search American Airlines flights

Frequently asked questions about flying from Guayaquil to Knoxville

  • How do I get Price Alerts for flights from Guayaquil to Knoxville?

    You can take advantage of momondo’s Price Alerts by first searching for your flights to Guayaquil from Knoxville. Flight offers will be shown to you in real-time. From there you can create a Price Alert by using our on-site widget.

  • How can I save money on flights from Guayaquil to Knoxville with momondo?

    With “Price Forecast”, learn how soon you should book your flight in advance. Down to the day of week and time of day, our information can inform you on the ideal time to book to save on your travel. Our “Price Calendar” shows you at a quick glance when to book your travel for lower rates. By setting “Price Alerts” you can monitor changes in price and target the ideal time to book. Search for your trip destination by budget amount via our “Explore” feature. Whether you’re looking for ideas for your next travel adventure or cost-cutting tips, our “Discover” content is a great place to start.

  • How does momondo find its flight prices?

    momondo shows deals across 700+ competitors all at once. momondo is active in 30 international markets, so you can have access to a wide range of options from airlines and OTAs alike.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Knoxville?

Finding the right flight to Knoxville from Guayaquil is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Guayaquil to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Guayaquil on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Guayaquil to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Guayaquil.

I’m not ready to book a flight from Guayaquil to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Guayaquil are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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