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Cheap flights from Guayaquil to Knoxville from $239

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Knoxville departing on 2/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Guayaquil to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:49 am - 10:55 pmGYE-TYS
22h 06m1 stop
Multiple Airlines Logo
9:16 pm - 11:53 pmTYS-GYE
26h 37m1 stop
$621Multiple Airlines
Find Deal
Sat, Dec 27 - Sun, Jan 4
United Airlines Logo
12:20 pm - 7:50 pmGYE-TYS
31h 30m2 stops
United Airlines Logo
7:05 am - 11:42 pmTYS-GYE
16h 37m2 stops
$626United Airlines
Find Deal
Tue, Jan 20 - Fri, Feb 20
Multiple Airlines Logo
12:49 am - 10:15 amGYE-TYS
33h 26m2 stops
Multiple Airlines Logo
9:16 pm - 11:53 pmTYS-GYE
26h 37m1 stop
$633Multiple Airlines
Find Deal
Sat, Dec 27 - Sun, Jan 4
United Airlines Logo
12:20 pm - 7:55 pmGYE-TYS
31h 35m2 stops
United Airlines Logo
7:00 am - 11:42 pmTYS-GYE
17h 42m3 stops
$647United Airlines
Find Deal
Wed, Feb 18 - Wed, Apr 1
Multiple Airlines Logo
7:40 pm - 12:00 pmGYE-TYS
16h 20m1 stop
Multiple Airlines Logo
11:27 am - 10:40 pmTYS-GYE
12h 13m2 stops
$662Multiple Airlines
Find Deal
Sun, Feb 15 - Sun, May 17
United Airlines Logo
12:20 pm - 7:50 pmGYE-TYS
31h 30m2 stops
United Airlines Logo
4:55 pm - 11:42 pmTYS-GYE
30h 47m2 stops
$667United Airlines
Find Deal
Tue, Jan 20 - Fri, Feb 20
Multiple Airlines Logo
4:30 pm - 11:31 amGYE-TYS
43h 01m2 stops
Multiple Airlines Logo
9:16 pm - 11:53 pmTYS-GYE
26h 37m1 stop
$679Multiple Airlines
Find Deal
Sun, Dec 28 - Sun, Jan 4
United Airlines Logo
2:35 pm - 7:55 pmGYE-TYS
29h 20m2 stops
United Airlines Logo
9:15 am - 11:42 pmTYS-GYE
15h 27m2 stops
$698United Airlines
Find Deal
Wed, Feb 18 - Wed, Apr 1
American Airlines Logo
3:31 pm - 6:36 pmGYE-TYS
27h 05m1 stop
American Airlines Logo
7:15 am - 1:33 pmTYS-GYE
7h 18m1 stop
$701American Airlines
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Mon, Feb 16 - Thu, May 7
American Airlines Logo
7:15 am - 11:59 pmGYE-TYS
16h 44m1 stop
American Airlines Logo
6:00 am - 10:42 pmTYS-GYE
16h 42m1 stop
$702American Airlines
Find Deal
Tue, Jan 20 - Fri, Feb 20

United Airlines flights from Guayaquil to Knoxville

Our best United Airlines deals on Guayaquil to Knoxville flight tickets
United Airlines
Jan 20
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
31h 30m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
Feb 20
TYS7:05 amKnoxville McGhee Tyson
16h 37m
2 stops
GYE11:42 pmGuayaquil Jose Joaquin de Olmedo
$626
Find similar
United Airlines
Feb 18
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
31h 35m
2 stops
TYS7:55 pmKnoxville McGhee Tyson
Apr 1
TYS7:00 amKnoxville McGhee Tyson
17h 42m
3 stops
GYE11:42 pmGuayaquil Jose Joaquin de Olmedo
$647
Find similar
United Airlines
Jan 20
GYE12:20 pmGuayaquil Jose Joaquin de Olmedo
31h 30m
2 stops
TYS7:50 pmKnoxville McGhee Tyson
Feb 20
TYS4:55 pmKnoxville McGhee Tyson
30h 47m
2 stops
GYE11:42 pmGuayaquil Jose Joaquin de Olmedo
$667
Find similar

American Airlines flights from Guayaquil to Knoxville

Our best American Airlines deals on Guayaquil to Knoxville flight tickets
American Airlines
Feb 16
GYE3:31 pmGuayaquil Jose Joaquin de Olmedo
27h 05m
1 stop
TYS6:36 pmKnoxville McGhee Tyson
May 7
TYS7:15 amKnoxville McGhee Tyson
7h 18m
1 stop
GYE1:33 pmGuayaquil Jose Joaquin de Olmedo
$701
Find similar
American Airlines
Jan 20
GYE7:15 amGuayaquil Jose Joaquin de Olmedo
16h 44m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
Feb 20
TYS6:00 amKnoxville McGhee Tyson
16h 42m
1 stop
GYE10:42 pmGuayaquil Jose Joaquin de Olmedo
$702
Find similar
American Airlines
Feb 15
GYE3:31 pmGuayaquil Jose Joaquin de Olmedo
19h 32m
2 stops
TYS11:03 amKnoxville McGhee Tyson
May 16
TYS7:15 amKnoxville McGhee Tyson
14h 40m
1 stop
GYE8:55 pmGuayaquil Jose Joaquin de Olmedo
$706
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 12/27

12:49 am-10:55 pm

1 stop22h 06m

Knoxville McGhee Tyson

Sun 1/4

9:16 pm-11:53 pm

1 stop26h 37m

$621

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

12:20 pm-7:50 pm

2 stops31h 30m

Knoxville McGhee Tyson

Fri 2/20

7:05 am-11:42 pm

2 stops16h 37m

$626

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 12/27

12:49 am-10:15 am

2 stops33h 26m

Knoxville McGhee Tyson

Sun 1/4

9:16 pm-11:53 pm

1 stop26h 37m

$633

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

12:20 pm-7:55 pm

2 stops31h 35m

Knoxville McGhee Tyson

Wed 4/1

7:00 am-11:42 pm

3 stops17h 42m

$647

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 2/15

7:40 pm-12:00 pm

1 stop16h 20m

Knoxville McGhee Tyson

Sun 5/17

11:27 am-10:40 pm

2 stops12h 13m

$662

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

12:20 pm-7:50 pm

2 stops31h 30m

Knoxville McGhee Tyson

Fri 2/20

4:55 pm-11:42 pm

2 stops30h 47m

$667

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sun 12/28

4:30 pm-11:31 am

2 stops43h 01m

Knoxville McGhee Tyson

Sun 1/4

9:16 pm-11:53 pm

1 stop26h 37m

$679

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/18

2:35 pm-7:55 pm

2 stops29h 20m

Knoxville McGhee Tyson

Wed 4/1

9:15 am-11:42 pm

2 stops15h 27m

$698

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

3:31 pm-6:36 pm

1 stop27h 05m

Knoxville McGhee Tyson

Thu 5/7

7:15 am-1:33 pm

1 stop7h 18m

$701

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 1/20

7:15 am-11:59 pm

1 stop16h 44m

Knoxville McGhee Tyson

Fri 2/20

6:00 am-10:42 pm

1 stop16h 42m

$702

Flights are sorted by cheapest round-trip flights first.

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See travel insights to Knoxville from

How to get the cheapest flight ticket from Guayaquil to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Guayaquil to Knoxville is on a Monday. Travelers who choose to depart for Knoxville on a Monday will often find tickets for as low as $671. When flying out on a Wednesday, the most expensive travel day of the week, you can expect to see flight prices from Guayaquil to Knoxville for around $777.

When to book flights from Guayaquil to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Knoxville (GYE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Knoxville

Direct flights

None
There are no direct flights from Guayaquil to Knoxville. There are no popular flight routes from Guayaquil to Knoxville.
Search flight deals

  • How far is Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 2647.2 mi away from Guayaquil Jose Joaquin de Olmedo. In terms of flight time, this usually takes a little over 9h 51m.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Guayaquil to Knoxville?

Best airlines flying from Guayaquil to Knoxville

Compare and see reviews for airlines that fly from Guayaquil to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $388Free CancellationRating
7.4
9,017 reviews
Search United Airlines flights
DeltaPriceFrom $743Free CancellationRating
7.9
8,007 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Knoxville?

Finding the right flight to Knoxville from Guayaquil is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Guayaquil to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Guayaquil on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Guayaquil to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Guayaquil.

I’m not ready to book a flight from Guayaquil to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Guayaquil are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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