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Cheap flights from Guayaquil to Knoxville from $259

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Guayaquil to Knoxville departing on 1/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Guayaquil to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
12:13 am - 10:36 am
GYE
-
TYS
9h 23m1 stop
Multiple Airlines Logo
6:44 pm - 11:18 pm
TYS
-
GYE
29h 34m1 stop
$438Multiple Airlines
Tue, Mar 31 - Sun, Apr 5
Multiple Airlines Logo
12:59 am - 8:46 pm
GYE
-
TYS
19h 47m1 stop
Multiple Airlines Logo
11:27 am - 5:20 pm
TYS
-
GYE
30h 53m2 stops
$455Multiple Airlines
Sat, Feb 14 - Thu, May 14
Multiple Airlines Logo
12:13 am - 1:05 pm
GYE
-
TYS
35h 52m2 stops
Multiple Airlines Logo
6:44 pm - 11:18 pm
TYS
-
GYE
29h 34m1 stop
$524Multiple Airlines
Tue, Mar 31 - Sun, Apr 5
Multiple Airlines Logo
12:59 am - 10:08 am
GYE
-
TYS
9h 09m1 stop
Multiple Airlines Logo
11:27 am - 5:20 pm
TYS
-
GYE
30h 53m2 stops
$529Multiple Airlines
Mon, Feb 16 - Thu, May 14
Multiple Airlines Logo
6:55 pm - 10:25 pm
GYE
-
TYS
27h 30m2 stops
Multiple Airlines Logo
9:40 pm - 11:01 pm
TYS
-
GYE
26h 21m1 stop
$545Multiple Airlines
Sat, Feb 14 - Sun, May 10
Multiple Airlines Logo
12:59 am - 12:04 pm
GYE
-
TYS
11h 05m1 stop
Multiple Airlines Logo
11:56 am - 11:01 pm
TYS
-
GYE
12h 05m1 stop
$560Multiple Airlines
Wed, Feb 11 - Sat, May 16
Multiple Airlines Logo
12:59 am - 12:41 pm
GYE
-
TYS
11h 42m1 stop
Multiple Airlines Logo
11:27 am - 5:20 pm
TYS
-
GYE
30h 53m2 stops
$561Multiple Airlines
Thu, Feb 12 - Sun, May 10
Multiple Airlines Logo
12:13 am - 8:10 am
GYE
-
TYS
30h 57m1 stop
Multiple Airlines Logo
6:47 pm - 11:18 pm
TYS
-
GYE
29h 31m1 stop
$569Multiple Airlines
Thu, Mar 26 - Fri, Apr 3
Multiple Airlines Logo
12:59 am - 8:46 pm
GYE
-
TYS
19h 47m1 stop
Multiple Airlines Logo
9:40 pm - 11:01 pm
TYS
-
GYE
26h 21m1 stop
$570Multiple Airlines
Sat, Feb 14 - Thu, May 14
Multiple Airlines Logo
12:59 am - 12:41 pm
GYE
-
TYS
11h 42m1 stop
Multiple Airlines Logo
9:40 pm - 11:01 pm
TYS
-
GYE
26h 21m1 stop
$596Multiple Airlines
Thu, Feb 12 - Sun, May 10

United Airlines flights from Guayaquil to Knoxville

Our best United Airlines deals on Guayaquil to Knoxville flight tickets
United Airlines
Feb 15
GYE2:35 pmGuayaquil Jose Joaquin de Olmedo
51h 35m
2 stops
TYS6:10 pmKnoxville McGhee Tyson
May 14
TYS9:00 amKnoxville McGhee Tyson
33h 29m
2 stops
GYE5:29 pmGuayaquil Jose Joaquin de Olmedo
$626
Find similar
United Airlines
Feb 16
GYE8:34 amGuayaquil Jose Joaquin de Olmedo
33h 36m
2 stops
TYS6:10 pmKnoxville McGhee Tyson
May 7
TYS7:00 amKnoxville McGhee Tyson
17h 36m
3 stops
GYE11:36 pmGuayaquil Jose Joaquin de Olmedo
$647
Find similar
United Airlines
Mar 27
GYE2:35 pmGuayaquil Jose Joaquin de Olmedo
32h 09m
2 stops
TYS11:44 pmKnoxville McGhee Tyson
Apr 3
TYS9:00 amKnoxville McGhee Tyson
36h 53m
2 stops
GYE8:53 pmGuayaquil Jose Joaquin de Olmedo
$657
Find similar

American Airlines flights from Guayaquil to Knoxville

Our best American Airlines deals on Guayaquil to Knoxville flight tickets
American Airlines
Feb 19
GYE3:30 pmGuayaquil Jose Joaquin de Olmedo
20h 01m
2 stops
TYS11:31 amKnoxville McGhee Tyson
May 10
TYS5:57 pmKnoxville McGhee Tyson
20h 34m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
$703
Find similar
American Airlines
Feb 19
GYE7:12 amGuayaquil Jose Joaquin de Olmedo
16h 47m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
May 10
TYS6:38 pmKnoxville McGhee Tyson
19h 53m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
$707
Find similar
American Airlines
Mar 2
GYE7:12 amGuayaquil Jose Joaquin de Olmedo
16h 47m
1 stop
TYS11:59 pmKnoxville McGhee Tyson
May 16
TYS5:57 pmKnoxville McGhee Tyson
20h 34m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
$708
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Guayaquil to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 2, 2026.
Use the filters below to find and compare flights from Guayaquil to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 3/31

12:13 am-10:36 am

1 stop9h 23m

Knoxville McGhee Tyson

Sun 4/5

6:44 pm-11:18 pm

1 stop29h 34m

$438

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 2/14

12:59 am-8:46 pm

1 stop19h 47m

Knoxville McGhee Tyson

Thu 5/14

11:27 am-5:20 pm

2 stops30h 53m

$455

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Tue 3/31

12:13 am-1:05 pm

2 stops35h 52m

Knoxville McGhee Tyson

Sun 4/5

6:44 pm-11:18 pm

1 stop29h 34m

$524

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Mon 2/16

12:59 am-10:08 am

1 stop9h 09m

Knoxville McGhee Tyson

Thu 5/14

11:27 am-5:20 pm

2 stops30h 53m

$529

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 2/14

6:55 pm-10:25 pm

2 stops27h 30m

Knoxville McGhee Tyson

Sun 5/10

9:40 pm-11:01 pm

1 stop26h 21m

$545

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Wed 2/11

12:59 am-12:04 pm

1 stop11h 05m

Knoxville McGhee Tyson

Sat 5/16

11:56 am-11:01 pm

1 stop12h 05m

$560

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/12

12:59 am-12:41 pm

1 stop11h 42m

Knoxville McGhee Tyson

Sun 5/10

11:27 am-5:20 pm

2 stops30h 53m

$561

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 3/26

12:13 am-8:10 am

1 stop30h 57m

Knoxville McGhee Tyson

Fri 4/3

6:47 pm-11:18 pm

1 stop29h 31m

$569

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Sat 2/14

12:59 am-8:46 pm

1 stop19h 47m

Knoxville McGhee Tyson

Thu 5/14

9:40 pm-11:01 pm

1 stop26h 21m

$570

GuayaquilKnoxville

GYE - TYS

GYETYS

Guayaquil Jose Joaquin de Olmedo

Thu 2/12

12:59 am-12:41 pm

1 stop11h 42m

Knoxville McGhee Tyson

Sun 5/10

9:40 pm-11:01 pm

1 stop26h 21m

$596

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Knoxville from

How to get the cheapest flight ticket from Guayaquil to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson?

Copa Airlines is the most popular carrier operating from Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson

When to book flights from Guayaquil to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Guayaquil to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Guayaquil to Knoxville (GYE to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Guayaquil to Knoxville

Fastest flight time

17h 35m

Direct flights

None
The fastest flight from Guayaquil to Knoxville takes 17h 35m
There are no direct flights from Guayaquil to Knoxville. There are no popular flight routes from Guayaquil to Knoxville.
Search flight deals

  • How far is Guayaquil Jose Joaquin de Olmedo to Knoxville McGhee Tyson by plane?

    Knoxville McGhee Tyson is 2647.2 mi away from Guayaquil Jose Joaquin de Olmedo. In terms of flight time, this usually takes a little over 17h 35m.

  • When did momondo last update prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport were last updated today.

  • How many operators does momondo search for flights from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Guayaquil Jose Joaquin de Olmedo Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Guayaquil to Knoxville?

Best airlines flying from Guayaquil to Knoxville

Compare and see reviews for airlines that fly from Guayaquil to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
United AirlinesPriceFrom $388Free CancellationRating
7.4
9,132 reviews
Search United Airlines flights
DeltaPriceFrom $743Free CancellationRating
7.9
8,021 reviews
Search Delta flights

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Alcoa
Murphy
Crossville
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Guayaquil to Knoxville?

Finding the right flight to Knoxville from Guayaquil is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to Knoxville quick and easy, saving you time and money.

Can I find flights from Guayaquil to Knoxville with flexible booking policies on momondo?

Yes. All flights to Knoxville from Guayaquil on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Guayaquil to Knoxville?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Knoxville from Guayaquil.

I’m not ready to book a flight from Guayaquil to Knoxville right now. Can momondo alert me if prices change?

Price alerts on flights to Knoxville from Guayaquil are quick and easy to set up on momondo. Simply perform a search and select the price alert feature. It is as simple as that.

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