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Cheap flights from Greenville, North Carolina to Knoxville from $259

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville, North Carolina to Knoxville departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Greenville, North Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:00 am - 9:53 am
PGV
-
TYS
3h 53m
1 stop
American Airlines Logo
7:02 am - 10:40 am
TYS
-
PGV
3h 38m
1 stop
$407American Airlines
Tue, Feb 17 - Sat, Feb 21
American Airlines Logo
11:45 am - 5:37 pm
PGV
-
TYS
5h 52m
1 stop
American Airlines Logo
6:05 am - 5:35 pm
TYS
-
PGV
11h 30m
2 stops
$611American Airlines
Tue, Feb 17 - Sat, Feb 21
American Airlines Logo
6:00 am - 8:40 pm
PGV
-
TYS
14h 40m
2 stops
American Airlines Logo
11:42 am - 11:50 pm
TYS
-
PGV
12h 08m
2 stops
$694American Airlines
Tue, Feb 17 - Sat, Feb 21

American Airlines flights from Greenville, North Carolina to Knoxville

Our best American Airlines deals on Greenville, North Carolina to Knoxville flight tickets
American Airlines
Feb 17
PGV6:00 amPitt-Greenville
3h 53m
1 stop
TYS9:53 amKnoxville McGhee Tyson
Feb 21
TYS7:02 amKnoxville McGhee Tyson
3h 38m
1 stop
PGV10:40 amPitt-Greenville
$407
American Airlines
Feb 17
PGV11:45 amPitt-Greenville
5h 52m
1 stop
TYS5:37 pmKnoxville McGhee Tyson
Feb 21
TYS6:05 amKnoxville McGhee Tyson
11h 30m
2 stops
PGV5:35 pmPitt-Greenville
$611
American Airlines
Feb 17
PGV6:00 amPitt-Greenville
14h 40m
2 stops
TYS8:40 pmKnoxville McGhee Tyson
Feb 21
TYS11:42 amKnoxville McGhee Tyson
12h 08m
2 stops
PGV11:50 pmPitt-Greenville
$694

momondo Fare Finder

 
Customize your flight search to find flights from Greenville, North Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Greenville, North Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Tue 2/17

6:00 am-9:53 am

1 stop3h 53m

Knoxville McGhee Tyson

Sat 2/21

7:02 am-10:40 am

1 stop3h 38m

$407

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Tue 2/17

11:45 am-5:37 pm

1 stop5h 52m

Knoxville McGhee Tyson

Sat 2/21

6:05 am-5:35 pm

2 stops11h 30m

$611

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Tue 2/17

6:00 am-8:40 pm

2 stops14h 40m

Knoxville McGhee Tyson

Sat 2/21

11:42 am-11:50 pm

2 stops12h 08m

$694

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Thu 3/5

5:05 am-8:42 am

1 stop3h 37m

$259

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Thu 3/5

5:05 am-3:32 pm

2 stops10h 27m

$433

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Knoxville from

How to get the cheapest flight ticket from Greenville, North Carolina to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest airline that flies from Pitt-Greenville to Knoxville McGhee Tyson?

American Airlines is the most popular carrier operating from Pitt-Greenville to Knoxville McGhee Tyson

When to book flights from Greenville, North Carolina to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville, North Carolina to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville, North Carolina to Knoxville (PGV to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville, North Carolina to Knoxville

Fastest flight time

3h 53m

Direct flights

None
The fastest flight from Greenville, North Carolina to Knoxville takes 3h 53m
There are no direct flights from Greenville, North Carolina to Knoxville. There are no popular flight routes from Greenville, North Carolina to Knoxville.
Search flight deals

  • How far is Pitt-Greenville to Knoxville McGhee Tyson by plane?

    The distance between Pitt-Greenville and Knoxville McGhee Tyson is about 367.8 mi. Flights usually cover this in 3h 53m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Maryville
Alcoa
Murphy
Oak Ridge
Lenoir City
Newport
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Greenville to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Greenville to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Greenville to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Greenville to Knoxville?

Once you have performed a search for Greenville to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Greenville to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Greenville to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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