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Cheap flights from Greenville, North Carolina to Knoxville from $327

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville, North Carolina to Knoxville departing on 4/8. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Greenville, North Carolina to Knoxville

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
6:51 am - 11:59 am
PGV
-
TYS
5h 08m1 stop
American Airlines Logo
9:05 am - 2:17 pm
TYS
-
PGV
5h 12m1 stop
$327American Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
7:17 pm - 11:21 pm
PGV
-
TYS
4h 04m1 stop
American Airlines Logo
2:57 pm - 6:51 pm
TYS
-
PGV
3h 54m1 stop
$387American Airlines
Sat, Jan 17 - Sun, Jan 18
American Airlines Logo
6:51 am - 7:00 pm
PGV
-
TYS
12h 09m2 stops
American Airlines Logo
8:44 pm - 11:44 pm
TYS
-
PGV
3h 00m1 stop
$471American Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
5:56 pm - 9:58 pm
PGV
-
TYS
4h 02m1 stop
American Airlines Logo
5:00 am - 10:36 am
TYS
-
PGV
5h 36m1 stop
$527American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
11:02 am - 6:31 pm
PGV
-
TYS
7h 29m2 stops
American Airlines Logo
5:00 am - 10:36 am
TYS
-
PGV
5h 36m1 stop
$571American Airlines
Wed, Dec 31 - Sun, Jan 4
American Airlines Logo
10:57 am - 11:06 pm
PGV
-
TYS
12h 09m2 stops
American Airlines Logo
11:34 am - 11:44 pm
TYS
-
PGV
12h 10m2 stops
$629American Airlines
Wed, Apr 8 - Sat, Apr 11
American Airlines Logo
5:03 am - 4:38 pm
PGV
-
TYS
11h 35m2 stops
American Airlines Logo
10:49 am - 11:51 pm
TYS
-
PGV
13h 02m2 stops
$819American Airlines
Wed, Dec 31 - Sun, Jan 4

American Airlines flights from Greenville, North Carolina to Knoxville

Our best American Airlines deals on Greenville, North Carolina to Knoxville flight tickets
American Airlines
Apr 8
PGV6:51 amPitt-Greenville
5h 08m
1 stop
TYS11:59 amKnoxville McGhee Tyson
Apr 11
TYS9:05 amKnoxville McGhee Tyson
5h 12m
1 stop
PGV2:17 pmPitt-Greenville
$327
Find similar
American Airlines
Jan 17
PGV7:17 pmPitt-Greenville
4h 04m
1 stop
TYS11:21 pmKnoxville McGhee Tyson
Jan 18
TYS2:57 pmKnoxville McGhee Tyson
3h 54m
1 stop
PGV6:51 pmPitt-Greenville
$387
Find similar
American Airlines
Apr 8
PGV6:51 amPitt-Greenville
12h 09m
2 stops
TYS7:00 pmKnoxville McGhee Tyson
Apr 11
TYS8:44 pmKnoxville McGhee Tyson
3h 00m
1 stop
PGV11:44 pmPitt-Greenville
$471
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Greenville, North Carolina to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Greenville, North Carolina to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Wed 4/8

6:51 am-11:59 am

1 stop5h 08m

Knoxville McGhee Tyson

Sat 4/11

9:05 am-2:17 pm

1 stop5h 12m

$327

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Sat 1/17

7:17 pm-11:21 pm

1 stop4h 04m

Knoxville McGhee Tyson

Sun 1/18

2:57 pm-6:51 pm

1 stop3h 54m

$387

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Wed 4/8

6:51 am-7:00 pm

2 stops12h 09m

Knoxville McGhee Tyson

Sat 4/11

8:44 pm-11:44 pm

1 stop3h 00m

$471

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Wed 12/31

5:56 pm-9:58 pm

1 stop4h 02m

Knoxville McGhee Tyson

Sun 1/4

5:00 am-10:36 am

1 stop5h 36m

$527

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Wed 12/31

11:02 am-6:31 pm

2 stops7h 29m

Knoxville McGhee Tyson

Sun 1/4

5:00 am-10:36 am

1 stop5h 36m

$571

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Wed 4/8

10:57 am-11:06 pm

2 stops12h 09m

Knoxville McGhee Tyson

Sat 4/11

11:34 am-11:44 pm

2 stops12h 10m

$629

GreenvilleKnoxville

PGV - TYS

PGVTYS

Pitt-Greenville

Wed 12/31

5:03 am-4:38 pm

2 stops11h 35m

Knoxville McGhee Tyson

Sun 1/4

10:49 am-11:51 pm

2 stops13h 02m

$819

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

When to book flights from Greenville, North Carolina to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville, North Carolina to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville, North Carolina to Knoxville (PGV to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville, North Carolina to Knoxville

Fastest flight time

4h 02m

Direct flights

None
The fastest flight from Greenville, North Carolina to Knoxville takes 4h 02m
There are no direct flights from Greenville, North Carolina to Knoxville. There are no popular flight routes from Greenville, North Carolina to Knoxville.
Search flight deals

  • How far is Pitt-Greenville to Knoxville McGhee Tyson by plane?

    The distance between Pitt-Greenville and Knoxville McGhee Tyson is about 367.8 mi. Flights usually cover this in 4h 02m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport?

    Prices for flights from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Pitt-Greenville Airport to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The travel and health documents required for your trip to Knoxville McGhee Tyson Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Knoxville McGhee Tyson Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • How do I get Price Alerts for flights from Greenville, North Carolina to Knoxville?

    Search flight deals from Greenville, North Carolina to Knoxville. While viewing offers you’ll have the option to create a Price Alert.

  • How can I save money on flights from Greenville, North Carolina to Knoxville with momondo?

    Plan your trips smart with the “Price Forecast” feature, which uses flight data to help you pick the best days to fly for the lowest fares. Our “Price Calendar” helps you get the most for your money by showing you when it’s most advantageous to fly. Curate your own travel experiences for less with “Explore”. Expert travel hacks to fuel your next adventure are a click away with “Discover” by momondo. Set up our “Price Alerts” to track fare changes and book when prices are at their lowest point.

  • How does momondo find its flight prices?

    We compare prices from 700+ competitors to help you find the price that works best for you. momondo operates in over 30 international markets, bringing you access to a wide range of fares and deals. Search for your travel using momondo for a diverse range of options from airlines and OTAs.

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Maryville
Crossville
Murphy
Alcoa
Oak Ridge
Newport
Lenoir City
Kodak
Dandridge
Jefferson City
Clinton
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Knoxville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Greenville to Knoxville. momondo saves you time and could save you money on your trip.

Can I find flights from Greenville to Knoxville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Greenville to Knoxville flights to just show those with flexible booking policies.

How can momondo help me find flights from Greenville to Knoxville?

Once you have performed a search for Greenville to Knoxville flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Greenville to Knoxville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Greenville to Knoxville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.

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