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Cheap flights from Greenville to Buffalo from $149

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Greenville to Buffalo departing on 3/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Greenville to Buffalo

Cheap round-trip flights

Enter your travel dates to find the best prices.
Southwest Logo
1:55 pm - 8:30 pm
GSP
-
BUF
6h 35m
1 stop
Southwest Logo
9:10 am - 1:20 pm
BUF
-
GSP
4h 10m
1 stop
$303Southwest
Thu, Mar 5 - Mon, Mar 9
Multiple Airlines Logo
5:43 pm - 12:13 pm
GSP
-
BUF
18h 30m
2 stops
Multiple Airlines Logo
11:25 am - 7:38 pm
BUF
-
GSP
8h 13m
1 stop
$304Multiple Airlines
Fri, Apr 24 - Mon, Apr 27
Southwest Logo
12:25 pm - 8:30 pm
GSP
-
BUF
8h 05m
2 stops
Southwest Logo
5:55 pm - 9:50 pm
BUF
-
GSP
3h 55m
1 stop
$308Southwest
Thu, Mar 5 - Mon, Mar 9
Southwest Logo
12:25 pm - 8:30 pm
GSP
-
BUF
8h 05m
2 stops
Southwest Logo
12:05 pm - 10:45 pm
BUF
-
GSP
10h 40m
2 stops
$313Southwest
Thu, Mar 5 - Mon, Mar 9
American Airlines Logo
6:30 am - 11:58 am
GSP
-
BUF
5h 28m
1 stop
American Airlines Logo
5:30 am - 10:11 am
BUF
-
GSP
4h 41m
1 stop
$315American Airlines
Thu, Apr 23 - Mon, Apr 27
American Airlines Logo
6:00 am - 10:53 am
GSP
-
BUF
4h 53m
1 stop
American Airlines Logo
6:19 am - 10:15 am
BUF
-
GSP
3h 56m
1 stop
$335American Airlines
Thu, Mar 12 - Sun, Mar 15
American Airlines Logo
6:00 am - 11:14 am
GSP
-
BUF
5h 14m
1 stop
American Airlines Logo
6:00 am - 10:36 am
BUF
-
GSP
4h 36m
1 stop
$341American Airlines
Wed, Apr 22 - Tue, Apr 28
American Airlines Logo
6:00 am - 11:14 am
GSP
-
BUF
5h 14m
1 stop
American Airlines Logo
7:28 pm - 11:57 pm
BUF
-
GSP
4h 29m
1 stop
$343American Airlines
Fri, Apr 10 - Mon, Apr 13
American Airlines Logo
6:00 am - 3:11 pm
GSP
-
BUF
9h 11m
1 stop
American Airlines Logo
11:49 am - 10:19 pm
BUF
-
GSP
10h 30m
1 stop
$345American Airlines
Fri, Apr 17 - Sun, Apr 19
American Airlines Logo
7:38 pm - 11:39 pm
GSP
-
BUF
4h 01m
1 stop
American Airlines Logo
5:30 am - 1:14 pm
BUF
-
GSP
7h 44m
2 stops
$346American Airlines
Wed, Apr 22 - Tue, Apr 28

American Airlines flights from Greenville to Buffalo

Our best American Airlines deals on Greenville to Buffalo flight tickets
American Airlines
Apr 23
GSP6:30 amGreenville
5h 28m
1 stop
BUF11:58 amBuffalo
Apr 27
BUF5:30 amBuffalo
4h 41m
1 stop
GSP10:11 amGreenville
$315
American Airlines
Mar 12
GSP6:00 amGreenville
4h 53m
1 stop
BUF10:53 amBuffalo
Mar 15
BUF6:19 amBuffalo
3h 56m
1 stop
GSP10:15 amGreenville
$335
American Airlines
Apr 22
GSP6:00 amGreenville
5h 14m
1 stop
BUF11:14 amBuffalo
Apr 28
BUF6:00 amBuffalo
4h 36m
1 stop
GSP10:36 amGreenville
$341

Southwest flights from Greenville to Buffalo

Our best Southwest deals on Greenville to Buffalo flight tickets
Southwest
Mar 5
GSP1:55 pmGreenville
6h 35m
1 stop
BUF8:30 pmBuffalo
Mar 9
BUF9:10 amBuffalo
4h 10m
1 stop
GSP1:20 pmGreenville
$303
Southwest
Mar 5
GSP12:25 pmGreenville
8h 05m
2 stops
BUF8:30 pmBuffalo
Mar 9
BUF5:55 pmBuffalo
3h 55m
1 stop
GSP9:50 pmGreenville
$308
Southwest
Mar 5
GSP12:25 pmGreenville
8h 05m
2 stops
BUF8:30 pmBuffalo
Mar 9
BUF12:05 pmBuffalo
10h 40m
2 stops
GSP10:45 pmGreenville
$313

momondo Fare Finder

 
Customize your flight search to find flights from Greenville to Buffalo that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated February 7, 2026.
Use the filters below to find and compare flights from Greenville to Buffalo that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Thu 3/5

1:55 pm-8:30 pm

1 stop6h 35m

Buffalo

Mon 3/9

9:10 am-1:20 pm

1 stop4h 10m

$303

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Fri 4/24

5:43 pm-12:13 pm

2 stops18h 30m

Buffalo

Mon 4/27

11:25 am-7:38 pm

1 stop8h 13m

$304

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Thu 3/5

12:25 pm-8:30 pm

2 stops8h 05m

Buffalo

Mon 3/9

5:55 pm-9:50 pm

1 stop3h 55m

$308

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Thu 3/5

12:25 pm-8:30 pm

2 stops8h 05m

Buffalo

Mon 3/9

12:05 pm-10:45 pm

2 stops10h 40m

$313

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Thu 4/23

6:30 am-11:58 am

1 stop5h 28m

Buffalo

Mon 4/27

5:30 am-10:11 am

1 stop4h 41m

$315

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Thu 3/12

6:00 am-10:53 am

1 stop4h 53m

Buffalo

Sun 3/15

6:19 am-10:15 am

1 stop3h 56m

$335

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Wed 4/22

6:00 am-11:14 am

1 stop5h 14m

Buffalo

Tue 4/28

6:00 am-10:36 am

1 stop4h 36m

$341

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Fri 4/10

6:00 am-11:14 am

1 stop5h 14m

Buffalo

Mon 4/13

7:28 pm-11:57 pm

1 stop4h 29m

$343

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Fri 4/17

6:00 am-3:11 pm

1 stop9h 11m

Buffalo

Sun 4/19

11:49 am-10:19 pm

1 stop10h 30m

$345

GreenvilleBuffalo

GSP - BUF

GSPBUF

Greenville

Wed 4/22

7:38 pm-11:39 pm

1 stop4h 01m

Buffalo

Tue 4/28

5:30 am-1:14 pm

2 stops7h 44m

$346

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 14 resultsSorted by cheapest first
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See travel insights to Buffalo from

How to get the cheapest flight ticket from Greenville to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Buffalo?

If you aren’t able to travel during the month of September, then book flights to Buffalo from Greenville during March instead. Flights to Buffalo in March, while not as cheap as those in September, still average around $266.

How have Greenville to Buffalo flight prices changed over time?

As of February 2026, prices for Greenville to Buffalo flights are approximately 36% cheaper when compared to flights at the same time last year.

When to book flights from Greenville to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Greenville to Buffalo according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Greenville to Buffalo (GSP to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Greenville to Buffalo

Fastest flight time

4h 25m

Direct flights

None
The fastest flight from Greenville to Buffalo takes 4h 25m
There are no direct flights from Greenville to Buffalo. There are no popular flight routes from Greenville to Buffalo.
Search flight deals

  • How far is Greenville to Buffalo by plane?

    A flight from Greenville to Buffalo will travel around 585.9 mi. 4h 25m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Greenville Airport to Buffalo Airport?

    Prices for flights from Greenville Airport to Buffalo Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Greenville Airport to Buffalo Airport?

  • How old do you have to be to fly from Greenville Airport to Buffalo Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Greenville Airport to Buffalo Airport.

  • What documentation or ID do you need to fly to Buffalo Airport?

    The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Greenville to Buffalo?

Best airlines flying from Greenville to Buffalo

Compare and see reviews for airlines that fly from Greenville to Buffalo with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $216Free CancellationRating
7.9
8,162 reviews
Search Delta flights
American AirlinesPriceFrom $218Free CancellationRating
7.2
11,248 reviews
Search American Airlines flights
SouthwestPriceFrom $277Free CancellationRating
8.0
4,280 reviews
Search Southwest flights

Traveling to a place near Buffalo?

Book flights to Buffalo if you plan to visit one of these locations
Batavia
Cheektowaga
Amherst
Grand Island
Tonawanda
Williamsville
Orchard Park
Lockport
West Seneca
Bowmansville
East Aurora
Eden
Angola

Why use momondo?

Why should I use momondo to find a flight deal from Greenville to Buffalo?

It is quick and easy to find Greenville to Buffalo flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Buffalo that suits you.

Can I find flights from Greenville to Buffalo with flexible booking policies on momondo?

Yes. All flights to Buffalo from Greenville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Greenville to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Greenville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Greenville to Buffalo right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Greenville to Buffalo now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Buffalo and let you know when they change.

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