Cheap flights from Fort Myers to St. Louis from $127

In general, August is the cheapest month to fly from Fort Myers to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $222. The month of November is another great option to travel to St. Louis, with average flight prices from Fort Myers averaging around $266.

The cheapest day to depart on your flight to St. Louis is on a Saturday when prices can be found for as low as $266. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $450. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Fort Myers in the afternoon is the least expensive time of day to depart. momondo users have found prices as low as $380 when looking at flights departing in the afternoon. In the evening is when there is more demand to fly to St. Louis, so prices are often more expensive at around $430 per ticket.

Fly from Fort Myers SW Florida Intl to Lambert-St Louis for the best Fort Myers SW Florida Intl - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Fort Myers when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $361 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Fort Myers for as low as $252 on momondo.

There is only 1 cabin class available to choose from on Fort Myers SW Florida Intl to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

No. A direct flight is the cheapest option for a flight between Fort Myers to St. Louis.

As of April 2026, prices for Fort Myers to St. Louis flights are approximately 27% more expensive when compared to flights at the same time last year.

Delta is the most popular carrier operating from Fort Myers SW Florida Intl to Lambert-St Louis

Southwest, Delta and American Airlines are the top three most popular airlines that fly to St. Louis from Fort Myers according to our data. Southwest is the first choice among our users, with 57% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 4 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

As of April 2026, 1 flights take off from Fort Myers and land in St. Louis each day. The most common flight departure time for this route is 1:00PM, with 30% of daily flights taking off at noon.

As of April 2026, there are 12 flights per week flying from Fort Myers to St. Louis. The most common day of the week flights depart is Mon, with 33% of flights taking off on this day.