Cheap flights from Fort Myers to South Carolina from $45

The cheapest month to fly to South Carolina from Fort Myers is in January. Flight prices, which tend to average around $124, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of January, then book flights to South Carolina from Fort Myers during August instead. Flights to South Carolina in August, while not as cheap as those in January, still average around $131.

Our data shows that Saturday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $113. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $227.

Our data shows that the cheapest Fort Myers to South Carolina flights are usually those with departure times in the evening. Our users have found flights to South Carolina in the evening for as low as $116. Try not to purchase tickets in the morning because they tend to be around $197. Of course, these prices can vary depending on the time of year and what airport you fly to.

Fly from Fort Myers SW Florida Intl to Charleston for the best Fort Myers SW Florida Intl - South Carolina flight prices

You are more likely to see cheaper flights to South Carolina from Fort Myers when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $250 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Fort Myers for as low as $142 on momondo.

There are 2 cabin classes available to choose from on Fort Myers SW Florida Intl to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Breeze Airways, Frontier, and Delta are the most popular carriers operating from Fort Myers SW Florida Intl to South Carolina

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to South Carolina from Fort Myers according to our data. American Airlines is the first choice among our users, with 42% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 5 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

As of February 2026, there are 5 flights per day flying from Fort Myers to South Carolina. The most common time of day flights depart is 9:00PM, with 100% of flights taking off in the evening.

The number of flights available between Fort Myers and South Carolina is 38 per week as of February 2026. The most frequent departure day is Wed, with 34% of weekly flights leaving on this day.