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Cheap flights from Fort Myers to Florence from $495

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Florence departing on 10/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Find the cheapest flights from Fort Myers to Florence

Cheap round-trip flights

Enter your travel dates to find the best prices.
American Airlines Logo
5:44 pm - 12:13 am
RSW
-
FLO
6h 29m
1 stop
American Airlines Logo
5:31 am - 9:01 am
FLO
-
RSW
3h 30m
1 stop
$495American Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
4:24 pm - 9:47 pm
RSW
-
FLO
5h 23m
1 stop
American Airlines Logo
2:35 pm - 8:31 pm
FLO
-
RSW
5h 56m
1 stop
$507American Airlines
Wed, May 20 - Wed, May 27
American Airlines Logo
8:53 am - 12:13 am
RSW
-
FLO
15h 20m
2 stops
American Airlines Logo
6:31 pm - 10:38 am
FLO
-
RSW
16h 07m
2 stops
$652American Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
6:52 am - 9:47 pm
RSW
-
FLO
14h 55m
2 stops
American Airlines Logo
5:05 am - 5:43 pm
FLO
-
RSW
12h 38m
2 stops
$730American Airlines
Wed, May 20 - Wed, May 27
American Airlines Logo
8:53 am - 12:13 am
RSW
-
FLO
15h 20m
2 stops
American Airlines Logo
6:31 pm - 10:38 am
FLO
-
RSW
16h 07m
2 stops
$747American Airlines
Fri, Oct 2 - Sun, Oct 4
American Airlines Logo
12:01 pm - 12:13 am
RSW
-
FLO
12h 12m
2 stops
American Airlines Logo
5:31 am - 9:01 am
FLO
-
RSW
3h 30m
1 stop
$841American Airlines
Thu, Oct 1 - Sun, Oct 4
American Airlines Logo
10:28 am - 3:40 pm
RSW
-
FLO
5h 12m
1 stop
American Airlines Logo
6:31 pm - 10:38 am
FLO
-
RSW
16h 07m
2 stops
$855American Airlines
Fri, Oct 2 - Sun, Oct 4
American Airlines Logo
8:25 am - 9:47 pm
RSW
-
FLO
13h 22m
2 stops
American Airlines Logo
2:35 pm - 8:31 pm
FLO
-
RSW
5h 56m
1 stop
$879American Airlines
Wed, May 20 - Wed, May 27

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American Airlines flights from Fort Myers to Florence, South Carolina

Our best American Airlines deals on Fort Myers to Florence, South Carolina flight tickets
American Airlines
Oct 1
RSW5:44 pmFort Myers SW Florida Intl
6h 29m
1 stop
FLO12:13 amFlorence
Oct 4
FLO5:31 amFlorence
3h 30m
1 stop
RSW9:01 amFort Myers SW Florida Intl
$495
American Airlines
May 20
RSW4:24 pmFort Myers SW Florida Intl
5h 23m
1 stop
FLO9:47 pmFlorence
May 27
FLO2:35 pmFlorence
5h 56m
1 stop
RSW8:31 pmFort Myers SW Florida Intl
$507
American Airlines
Oct 1
RSW8:53 amFort Myers SW Florida Intl
15h 20m
2 stops
FLO12:13 amFlorence
Oct 4
FLO6:31 pmFlorence
16h 07m
2 stops
RSW10:38 amFort Myers SW Florida Intl
$652

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Florence, South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 4, 2026.
Use the filters below to find and compare flights from Fort Myers to Florence, South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Thu 10/1

5:44 pm-12:13 am

1 stop6h 29m

Florence

Sun 10/4

5:31 am-9:01 am

1 stop3h 30m

$495

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Wed 5/20

4:24 pm-9:47 pm

1 stop5h 23m

Florence

Wed 5/27

2:35 pm-8:31 pm

1 stop5h 56m

$507

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Thu 10/1

8:53 am-12:13 am

2 stops15h 20m

Florence

Sun 10/4

6:31 pm-10:38 am

2 stops16h 07m

$652

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Wed 5/20

6:52 am-9:47 pm

2 stops14h 55m

Florence

Wed 5/27

5:05 am-5:43 pm

2 stops12h 38m

$730

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Fri 10/2

8:53 am-12:13 am

2 stops15h 20m

Florence

Sun 10/4

6:31 pm-10:38 am

2 stops16h 07m

$747

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Thu 10/1

12:01 pm-12:13 am

2 stops12h 12m

Florence

Sun 10/4

5:31 am-9:01 am

1 stop3h 30m

$841

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Fri 10/2

10:28 am-3:40 pm

1 stop5h 12m

Florence

Sun 10/4

6:31 pm-10:38 am

2 stops16h 07m

$855

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Wed 5/20

8:25 am-9:47 pm

2 stops13h 22m

Florence

Wed 5/27

2:35 pm-8:31 pm

1 stop5h 56m

$879

Flights are sorted by cheapest round-trip flights first.

Sorted by cheapest first

See travel insights to Florence from

How to get the cheapest flight ticket from Fort Myers to Florence, South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What airlines fly to Florence, South Carolina?

American Airlines, Delta and Breeze Airways are the top three most popular airlines that fly to Florence, South Carolina from Fort Myers according to our data. American Airlines is the first choice among our users, with 73% of people opting to fly with this airline when traveling to Florence, South Carolina. Keep in mind that there are 4 different airlines that fly to Florence, South Carolina on a routine basis, so you have a few additional options to choose from.

When to book flights from Fort Myers to Florence, South Carolina

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Florence, South Carolina according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Florence, South Carolina (RSW to FLO) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Florence, South Carolina

Fastest flight time

5h 23m

Direct flights

None
The fastest flight from Fort Myers to Florence, South Carolina takes 5h 23m
There are no direct flights from Fort Myers to Florence, South Carolina. There are no popular flight routes from Fort Myers to Florence, South Carolina.
Search flight deals

Frequently asked questions about flying from Fort Myers to Florence, South Carolina

  • How far is Fort Myers SW Florida Intl to Florence by plane?

    A flight from Fort Myers SW Florida Intl to Florence will travel around 536.5 mi. Typically, this will take 5h 23m by plane in normal conditions.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Florence Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Florence Airport are refreshed on a daily basis.

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Florence Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Fort Myers SW Florida Intl Airport to Florence Airport.

  • What documentation or ID do you need to fly to Florence Airport?

    The required travel and health documents for your Florence Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Florence Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington
Bennettsville
Lake City

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Florence?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Fort Myers to Florence for you.

Can I find flights from Fort Myers to Florence with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Fort Myers to Florence flights to just show those with flexible booking policies.

How can momondo help me find flights from Fort Myers to Florence?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to Florence from Fort Myers.

I’m not ready to book a flight from Fort Myers to Florence right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Florence from Fort Myers. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

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