How many flights depart from Fort Myers to Des Moines on average per week?

The number of flights available between Fort Myers and Des Moines is 2 per week as of December 2025. The most frequent departure day is Mon, with 50% of weekly flights leaving on this day.

What is the cheapest airline that flies from Fort Myers SW Florida Intl to Des Moines?

American Airlines is the most popular carrier operating from Fort Myers SW Florida Intl to Des Moines

What airlines fly to Des Moines?

American Airlines, Allegiant Air and Delta are the top three most popular airlines that fly to Des Moines from Fort Myers according to our data. American Airlines is the first choice among our users, with 32% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 4 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

As of December 2025, there are 2 operators available to choose from for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport.

How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$131 Cheap Flights from Fort Myers to Des Moines in 2025/26

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11:26 am - 2:08 pm

RSW

DSM

27h 42m2 stops

2:08 pm - 6:12 pm

DSM

RSW

3h 04mnonstop

$249Multiple Airlines

Sat, Jan 10 - Mon, Jan 12

7:02 pm - 9:21 pm

RSW

DSM

3h 19mnonstop

2:08 pm - 6:12 pm

DSM

RSW

3h 04mnonstop

$261Allegiant Air

Mon, Jan 19 - Mon, Jan 26

1:15 pm - 10:09 pm

RSW

DSM

33h 54m3 stops

2:08 pm - 6:12 pm

DSM

RSW

3h 04mnonstop

$326Multiple Airlines

Sat, Jan 10 - Mon, Jan 12

6:00 am - 11:24 am

RSW

DSM

6h 24m1 stop

10:14 am - 6:32 pm

DSM

RSW

7h 18m1 stop

$332Delta

Sun, Jan 11 - Sun, Jan 18

6:28 am - 11:12 am

RSW

DSM

5h 44m1 stop

6:00 am - 5:45 pm

DSM

RSW

10h 45m2 stops

$337American Airlines

Sun, Jan 11 - Sun, Jan 18

8:40 am - 4:24 pm

RSW

DSM

8h 44m2 stops

1:55 pm - 11:33 pm

DSM

RSW

8h 38m2 stops

$342American Airlines

Sun, Jan 11 - Sun, Jan 18

3:07 pm - 10:11 pm

RSW

DSM

8h 04m2 stops

11:42 am - 11:33 pm

DSM

RSW

10h 51m2 stops

$348American Airlines

Sat, Jan 10 - Mon, Jan 12

7:02 pm - 9:21 pm

RSW

DSM

3h 19mnonstop

11:09 am - 11:24 pm

DSM

RSW

35h 15m3 stops

$371Multiple Airlines

Mon, Jan 19 - Mon, Jan 26

6:28 am - 11:12 am

RSW

DSM

5h 44m1 stop

2:02 pm - 8:45 pm

DSM

RSW

5h 43m1 stop

$373American Airlines

Mon, Feb 9 - Fri, Feb 13

1:12 pm - 10:11 pm

RSW

DSM

9h 59m2 stops

2:02 pm - 8:45 pm

DSM

RSW

5h 43m1 stop

$378American Airlines

Mon, Feb 9 - Fri, Feb 13

American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets

American Airlines

Jan 11

RSW6:28 amFort Myers SW Florida Intl

5h 44m

1 stop

DSM11:12 amDes Moines

Jan 18

DSM6:00 amDes Moines

10h 45m

2 stops

RSW5:45 pmFort Myers SW Florida Intl

$337

Find similar

American Airlines

Jan 11

RSW8:40 amFort Myers SW Florida Intl

8h 44m

2 stops

DSM4:24 pmDes Moines

Jan 18

DSM1:55 pmDes Moines

8h 38m

2 stops

RSW11:33 pmFort Myers SW Florida Intl

$342

Find similar

American Airlines

Jan 10

RSW3:07 pmFort Myers SW Florida Intl

8h 04m

2 stops

DSM10:11 pmDes Moines

Jan 12

DSM11:42 amDes Moines

10h 51m

2 stops

RSW11:33 pmFort Myers SW Florida Intl

$348

Find similar

United Airlines flights from Fort Myers to Des Moines

Our best United Airlines deals on Fort Myers to Des Moines flight tickets

United Airlines

Jan 19

RSW3:59 pmFort Myers SW Florida Intl

8h 45m

1 stop

DSM11:44 pmDes Moines

Jan 26

DSM8:00 amDes Moines

5h 53m

1 stop

RSW2:53 pmFort Myers SW Florida Intl

$400

Find similar

United Airlines

Jan 19

RSW3:59 pmFort Myers SW Florida Intl

8h 45m

1 stop

DSM11:44 pmDes Moines

Jan 26

DSM8:00 amDes Moines

12h 59m

2 stops

RSW9:59 pmFort Myers SW Florida Intl

$405

Find similar

United Airlines

Feb 20

RSW2:23 pmFort Myers SW Florida Intl

8h 18m

1 stop

DSM9:41 pmDes Moines

Feb 23

DSM3:24 pmDes Moines

5h 53m

1 stop

RSW10:17 pmFort Myers SW Florida Intl

$449

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 1/10

11:26 am-2:08 pm

2 stops27h 42m

Des Moines

Mon 1/12

2:08 pm-6:12 pm

Nonstop3h 04m

$249

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 1/19

7:02 pm-9:21 pm

Nonstop3h 19m

Des Moines

Mon 1/26

2:08 pm-6:12 pm

Nonstop3h 04m

$261

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 1/10

1:15 pm-10:09 pm

3 stops33h 54m

Des Moines

Mon 1/12

2:08 pm-6:12 pm

Nonstop3h 04m

$326

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sun 1/11

6:00 am-11:24 am

1 stop6h 24m

Des Moines

Sun 1/18

10:14 am-6:32 pm

1 stop7h 18m

$332

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sun 1/11

6:28 am-11:12 am

1 stop5h 44m

Des Moines

Sun 1/18

6:00 am-5:45 pm

2 stops10h 45m

$337

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sun 1/11

8:40 am-4:24 pm

2 stops8h 44m

Des Moines

Sun 1/18

1:55 pm-11:33 pm

2 stops8h 38m

$342

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 1/10

3:07 pm-10:11 pm

2 stops8h 04m

Des Moines

Mon 1/12

11:42 am-11:33 pm

2 stops10h 51m

$348

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 1/19

7:02 pm-9:21 pm

Nonstop3h 19m

Des Moines

Mon 1/26

11:09 am-11:24 pm

3 stops35h 15m

$371

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 2/9

6:28 am-11:12 am

1 stop5h 44m

Des Moines

Fri 2/13

2:02 pm-8:45 pm

1 stop5h 43m

$373

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 2/9

1:12 pm-10:11 pm

2 stops9h 59m

Des Moines

Fri 2/13

2:02 pm-8:45 pm

1 stop5h 43m

$378

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How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then November is your next best option. Flight prices from Fort Myers to Des Moines during November average around $261.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Fort Myers to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $406. Flights from Fort Myers to Des Moines on a Tuesday will generally be more expensive and average around $462. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Fort Myers to Des Moines in the afternoon for as low as $165. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $503. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers SW Florida Intl to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers SW Florida Intl to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Fort Myers to Des Moines.

How have Fort Myers to Des Moines flight prices changed over time?

When to book flights from Fort Myers to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Fastest flight time	3h 19m
Direct flights	Tue
Airports in Des Moines	1 airport

The fastest flight from Fort Myers to Des Moines takes 3h 19m

Direct flights go from Fort Myers to Des Moines on Tuesday. There are no airlines offering direct flights.

There is 1 airport in Des Moines. From Fort Myers there are direct flights to Des Moines (DSM).

Search flight deals

How far is Fort Myers SW Florida Intl to Des Moines by plane?
A flight from Fort Myers SW Florida Intl to Des Moines will travel around 1228.7 mi. Typically, this will take 3h 19m by plane in normal conditions.
When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?
Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?
As of December 2025, there are 2 operators available to choose from for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport.
How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Fort Myers to Des Moines?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Fort Myers to Des Moines is Airbus A320-100/200 (100.00% of total bookings).
What is the most popular airline from Fort Myers to Des Moines?
Based on momondo bookings for flights between Fort Myers and Des Moines, the leading airline is American Airlines, making up 50% of the total bookings. Other popular airlines include Southwest with 50%.

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $236	Free Cancellation	Rating 7.2 11,050 reviews		Search American Airlines flights
Southwest	PriceFrom $346	Free Cancellation	Rating 8.0 4,257 reviews		Search Southwest flights

West Des Moines

Ames

Ankeny

Altoona

Urbandale

Clive

Pella

Newton

Johnston

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

It is quick and easy to find Fort Myers to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Fort Myers which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Fort Myers to Des Moines?

Once you have performed a search for Fort Myers to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Fort Myers to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

An easier way to manage your Des Moines trip

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Cheap flights from Fort Myers to Des Moines from $131

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Des Moines departing on 2/10. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets

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Our best United Airlines deals on Fort Myers to Des Moines flight tickets

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Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

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How to get the cheapest flight ticket from Fort Myers to Des Moines

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then November is your next best option. Flight prices from Fort Myers to Des Moines during November average around $261.

What is the cheapest day to depart on your flight to Des Moines?

What is the cheapest time of day to depart on your flight to Des Moines?

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers SW Florida Intl to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers SW Florida Intl to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Fort Myers to Des Moines.

How have Fort Myers to Des Moines flight prices changed over time?

What is the cheapest airline that flies from Fort Myers SW Florida Intl to Des Moines?

American Airlines is the most popular carrier operating from Fort Myers SW Florida Intl to Des Moines

What airlines fly to Des Moines?

How many flights depart from Fort Myers to Des Moines on average per week?

The number of flights available between Fort Myers and Des Moines is 2 per week as of December 2025. The most frequent departure day is Mon, with 50% of weekly flights leaving on this day.

When to book flights from Fort Myers to Des Moines

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Fastest flight time

Direct flights

Airports in Des Moines

How far is Fort Myers SW Florida Intl to Des Moines by plane?

When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

What documentation or ID do you need to fly to Des Moines Airport?

What is the most popular plane model from Fort Myers to Des Moines?

What is the most popular airline from Fort Myers to Des Moines?

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo

Traveling to a place near Des Moines?

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

How can momondo help me find flights from Fort Myers to Des Moines?

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Iowa