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Cheap flights from Fort Myers to Des Moines from $144

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Des Moines departing on 4/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
10:54 am - 1:13 pm
RSW
-
DSM
3h 19mnonstop
Allegiant Air Logo
6:00 am - 10:04 am
DSM
-
RSW
3h 04mnonstop
$271Allegiant Air
Fri, Apr 10 - Mon, Apr 13
United Airlines Logo
4:34 pm - 9:40 pm
RSW
-
DSM
6h 06m
1 stop
United Airlines Logo
6:00 am - 2:44 pm
DSM
-
RSW
7h 44m
1 stop
$339United Airlines
Thu, Jul 16 - Thu, Jul 23
Multiple Airlines Logo
6:00 am - 7:14 pm
RSW
-
DSM
14h 14m
2 stops
Multiple Airlines Logo
6:00 am - 10:04 am
DSM
-
RSW
3h 04mnonstop
$343Multiple Airlines
Fri, Apr 10 - Mon, Apr 13
American Airlines Logo
5:50 pm - 11:59 pm
RSW
-
DSM
7h 09m
1 stop
American Airlines Logo
2:02 pm - 8:55 pm
DSM
-
RSW
5h 53m
1 stop
$358American Airlines
Sat, Apr 18 - Wed, Apr 22
American Airlines Logo
6:00 am - 1:46 pm
RSW
-
DSM
8h 46m
2 stops
American Airlines Logo
2:02 pm - 8:55 pm
DSM
-
RSW
5h 53m
1 stop
$363American Airlines
Sat, Apr 18 - Wed, Apr 22
Delta Logo
8:10 am - 12:07 pm
RSW
-
DSM
4h 57m
1 stop
Delta Logo
2:15 pm - 9:17 pm
DSM
-
RSW
6h 02m
1 stop
$367Delta
Sat, Jul 4 - Wed, Jul 8
American Airlines Logo
6:00 am - 1:46 pm
RSW
-
DSM
8h 46m
2 stops
American Airlines Logo
11:09 am - 8:55 pm
DSM
-
RSW
8h 46m
2 stops
$368American Airlines
Sat, Apr 18 - Wed, Apr 22
Multiple Airlines Logo
5:24 pm - 7:14 pm
RSW
-
DSM
26h 50m
1 stop
Multiple Airlines Logo
7:00 am - 6:19 pm
DSM
-
RSW
10h 19m
1 stop
$377Multiple Airlines
Thu, Apr 2 - Sun, Apr 12
American Airlines Logo
8:06 am - 1:11 pm
RSW
-
DSM
6h 05m
1 stop
American Airlines Logo
8:56 am - 5:34 pm
DSM
-
RSW
7h 38m
1 stop
$383American Airlines
Thu, May 14 - Sun, May 17
American Airlines Logo
6:33 pm - 11:49 pm
RSW
-
DSM
6h 16m
1 stop
American Airlines Logo
11:09 am - 8:55 pm
DSM
-
RSW
8h 46m
2 stops
$388American Airlines
Thu, Apr 23 - Sun, Apr 26

American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets
American Airlines
Apr 18
RSW5:50 pmFort Myers SW Florida Intl
7h 09m
1 stop
DSM11:59 pmDes Moines
Apr 22
DSM2:02 pmDes Moines
5h 53m
1 stop
RSW8:55 pmFort Myers SW Florida Intl
$358
American Airlines
Apr 18
RSW6:00 amFort Myers SW Florida Intl
8h 46m
2 stops
DSM1:46 pmDes Moines
Apr 22
DSM2:02 pmDes Moines
5h 53m
1 stop
RSW8:55 pmFort Myers SW Florida Intl
$363
American Airlines
Apr 18
RSW6:00 amFort Myers SW Florida Intl
8h 46m
2 stops
DSM1:46 pmDes Moines
Apr 22
DSM11:09 amDes Moines
8h 46m
2 stops
RSW8:55 pmFort Myers SW Florida Intl
$368

United Airlines flights from Fort Myers to Des Moines

Our best United Airlines deals on Fort Myers to Des Moines flight tickets
United Airlines
Jul 16
RSW4:34 pmFort Myers SW Florida Intl
6h 06m
1 stop
DSM9:40 pmDes Moines
Jul 23
DSM6:00 amDes Moines
7h 44m
1 stop
RSW2:44 pmFort Myers SW Florida Intl
$339
United Airlines
Apr 17
RSW4:37 pmFort Myers SW Florida Intl
5h 55m
1 stop
DSM9:32 pmDes Moines
Apr 20
DSM6:20 amDes Moines
5h 56m
1 stop
RSW1:16 pmFort Myers SW Florida Intl
$378
United Airlines
May 2
RSW6:45 amFort Myers SW Florida Intl
8h 32m
1 stop
DSM2:17 pmDes Moines
May 5
DSM8:00 amDes Moines
5h 37m
1 stop
RSW2:37 pmFort Myers SW Florida Intl
$429

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 4/10

10:54 am-1:13 pm

Nonstop3h 19m

Des Moines

Mon 4/13

6:00 am-10:04 am

Nonstop3h 04m

$271

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 7/16

4:34 pm-9:40 pm

1 stop6h 06m

Des Moines

Thu 7/23

6:00 am-2:44 pm

1 stop7h 44m

$339

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 4/10

6:00 am-7:14 pm

2 stops14h 14m

Des Moines

Mon 4/13

6:00 am-10:04 am

Nonstop3h 04m

$343

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 4/18

5:50 pm-11:59 pm

1 stop7h 09m

Des Moines

Wed 4/22

2:02 pm-8:55 pm

1 stop5h 53m

$358

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 4/18

6:00 am-1:46 pm

2 stops8h 46m

Des Moines

Wed 4/22

2:02 pm-8:55 pm

1 stop5h 53m

$363

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 7/4

8:10 am-12:07 pm

1 stop4h 57m

Des Moines

Wed 7/8

2:15 pm-9:17 pm

1 stop6h 02m

$367

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 4/18

6:00 am-1:46 pm

2 stops8h 46m

Des Moines

Wed 4/22

11:09 am-8:55 pm

2 stops8h 46m

$368

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 4/2

5:24 pm-7:14 pm

1 stop26h 50m

Des Moines

Sun 4/12

7:00 am-6:19 pm

1 stop10h 19m

$377

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 5/14

8:06 am-1:11 pm

1 stop6h 05m

Des Moines

Sun 5/17

8:56 am-5:34 pm

1 stop7h 38m

$383

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 4/23

6:33 pm-11:49 pm

1 stop6h 16m

Des Moines

Sun 4/26

11:09 am-8:55 pm

2 stops8h 46m

$388

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then January is your next best option. Flight prices from Fort Myers to Des Moines during January average around $200.

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers SW Florida Intl to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers SW Florida Intl to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

You could potentially save up to 5% on your flight if you consider stops on a Fort Myers to Des Moines flight.

How have Fort Myers to Des Moines flight prices changed over time?

When to book flights from Fort Myers to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Fastest flight time

3h 19m

Direct flights

Tue and Sat

Airports in Des Moines

1 airport
The fastest flight from Fort Myers to Des Moines takes 3h 19m
Direct flights go from Fort Myers to Des Moines on Tuesday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Des Moines. From Fort Myers there are direct flights to Des Moines (DSM).
Search flight deals

  • How far is Fort Myers SW Florida Intl to Des Moines by plane?

    A flight from Fort Myers SW Florida Intl to Des Moines will travel around 1228.7 mi. Typically, this will take 3h 19m by plane in normal conditions.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Fort Myers to Des Moines?

  • What is the most popular airline from Fort Myers to Des Moines?

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $152Free CancellationRating
7.9
8,320 reviews
Search Delta flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

It is quick and easy to find Fort Myers to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Fort Myers which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Fort Myers to Des Moines?

Once you have performed a search for Fort Myers to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Fort Myers to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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