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Cheap flights from Fort Myers to Des Moines from $52

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Des Moines departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Fort Myers to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Allegiant Air Logo
7:53 pm - 10:08 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
3h 15mnonstop
Allegiant Air Logo
10:05 am - 2:04 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
2h 59mnonstop
$75Allegiant Air
Fri, Sep 4 - Mon, Sep 14
Allegiant Air Logo
7:53 pm - 10:08 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
3h 15mnonstop
Allegiant Air Logo
2:49 pm - 6:48 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
2h 59mnonstop
$144Allegiant Air
Fri, Oct 23 - Mon, Oct 26
Allegiant Air Logo
7:53 pm - 10:08 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
3h 15mnonstop
Allegiant Air Logo
2:51 pm - 6:50 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
2h 59mnonstop
$145Allegiant Air
Fri, Sep 4 - Mon, Sep 7
Multiple Airlines Logo
7:53 pm - 10:08 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
3h 15mnonstop
Multiple Airlines Logo
9:11 pm - 10:39 amDSM  Des Moines-RSW Fort Myers SW Florida Intl
36h 28m2 stops Las Vegas Harry Reid Intl Cleveland Hopkins Intl
$238Multiple Airlines
Fri, Oct 23 - Mon, Oct 26
Multiple Airlines Logo
10:52 am - 7:57 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
10h 05m1 stop Philadelphia
Multiple Airlines Logo
1:58 pm - 11:51 amDSM  Des Moines-RSW Fort Myers SW Florida Intl
20h 53m1 stop Philadelphia
$240Multiple Airlines
Thu, Sep 3 - Thu, Sep 10
Multiple Airlines Logo
7:00 am - 10:44 amRSW  Fort Myers SW Florida Intl-DSM Des Moines
28h 44m3 stops Raleigh-Durham Atlanta Hartsfield-Jackson Denver Intl
Multiple Airlines Logo
10:05 am - 2:04 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
2h 59mnonstop
$245Multiple Airlines
Wed, Sep 23 - Mon, Sep 28
Delta Logo
1:12 pm - 6:09 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
5h 57m1 stop Atlanta Hartsfield-Jackson
Delta Logo
4:10 pm - 12:35 amDSM  Des Moines-RSW Fort Myers SW Florida Intl
7h 25m1 stop Atlanta Hartsfield-Jackson
$281Delta
Wed, Sep 23 - Sat, Oct 3
Delta Logo
5:30 am - 10:46 amRSW  Fort Myers SW Florida Intl-DSM Des Moines
6h 16m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:54 pm - 12:35 amDSM  Des Moines-RSW Fort Myers SW Florida Intl
4h 41m1 stop Atlanta Hartsfield-Jackson
$281Delta
Tue, Sep 22 - Tue, Sep 29
American Airlines Logo
7:12 pm - 12:04 amRSW  Fort Myers SW Florida Intl-DSM Des Moines
5h 52m1 stop Chicago O'Hare Intl
American Airlines Logo
2:29 pm - 11:09 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
7h 40m1 stop Chicago O'Hare Intl
$320American Airlines
Fri, Sep 25 - Wed, Sep 30
American Airlines Logo
3:07 pm - 10:11 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
8h 04m2 stops Charlotte Douglas Washington, D.C. Reagan-National
American Airlines Logo
9:26 am - 4:12 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
5h 46m1 stop Chicago O'Hare Intl
$337American Airlines
Wed, Jan 13 - Tue, Jan 19

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Allegiant Air flights from Fort Myers to Des Moines

Our best Allegiant Air deals on Fort Myers to Des Moines flight tickets
Allegiant Air
Sep 4
RSW7:53 pmFort Myers SW Florida Intl
3h 15m
DSM10:08 pmDes Moines
Sep 14
DSM10:05 amDes Moines
2h 59m
RSW2:04 pmFort Myers SW Florida Intl
$75
Allegiant Air
Oct 23
RSW7:53 pmFort Myers SW Florida Intl
3h 15m
DSM10:08 pmDes Moines
Oct 26
DSM2:49 pmDes Moines
2h 59m
RSW6:48 pmFort Myers SW Florida Intl
$144
Allegiant Air
Sep 4
RSW7:53 pmFort Myers SW Florida Intl
3h 15m
DSM10:08 pmDes Moines
Sep 7
DSM2:51 pmDes Moines
2h 59m
RSW6:50 pmFort Myers SW Florida Intl
$145

American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets
American Airlines
Jan 13
RSW3:07 pmFort Myers SW Florida Intl
8h 04m
2 stops
DSM10:11 pmDes Moines
Jan 19
DSM9:26 amDes Moines
5h 46m
1 stop
RSW4:12 pmFort Myers SW Florida Intl
$337
American Airlines
Sep 4
RSW11:04 amFort Myers SW Florida Intl
6h 23m
1 stop
DSM4:27 pmDes Moines
Sep 7
DSM1:55 pmDes Moines
8h 04m
1 stop
RSW10:59 pmFort Myers SW Florida Intl
$362
American Airlines
Sep 25
RSW4:14 pmFort Myers SW Florida Intl
8h 27m
2 stops
DSM11:41 pmDes Moines
Sep 30
DSM2:29 pmDes Moines
7h 40m
1 stop
RSW11:09 pmFort Myers SW Florida Intl
$363

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 15, 2026.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Fri 9/4

7:53 pm-10:08 pm

Nonstop3h 15m

Des Moines

Mon 9/14

10:05 am-2:04 pm

Nonstop2h 59m

$75

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Fri 10/23

7:53 pm-10:08 pm

Nonstop3h 15m

Des Moines

Mon 10/26

2:49 pm-6:48 pm

Nonstop2h 59m

$144

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Fri 9/4

7:53 pm-10:08 pm

Nonstop3h 15m

Des Moines

Mon 9/7

2:51 pm-6:50 pm

Nonstop2h 59m

$145

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Fri 10/23

7:53 pm-10:08 pm

Nonstop3h 15m

Des Moines

Mon 10/26

9:11 pm-10:39 am

2 stops36h 28m

$238

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Thu 9/3

10:52 am-7:57 pm

1 stop10h 05m

Des Moines

Thu 9/10

1:58 pm-11:51 am

1 stop20h 53m

$240

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 9/23

7:00 am-10:44 am

3 stops28h 44m

Des Moines

Mon 9/28

10:05 am-2:04 pm

Nonstop2h 59m

$245

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 9/23

1:12 pm-6:09 pm

1 stop5h 57m

Des Moines

Sat 10/3

4:10 pm-12:35 am

1 stop7h 25m

$281

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Tue 9/22

5:30 am-10:46 am

1 stop6h 16m

Des Moines

Tue 9/29

6:54 pm-12:35 am

1 stop4h 41m

$281

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Fri 9/25

7:12 pm-12:04 am

1 stop5h 52m

Des Moines

Wed 9/30

2:29 pm-11:09 pm

1 stop7h 40m

$320

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 1/13

3:07 pm-10:11 pm

2 stops8h 04m

Des Moines

Tue 1/19

9:26 am-4:12 pm

1 stop5h 46m

$337

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in November, then October is your next best option. Flight prices from Fort Myers to Des Moines during October average around $187.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Fort Myers to Des Moines is on a Monday. Travelers who choose to depart for Des Moines on a Monday will often find tickets for as low as $189. Flights from Fort Myers to Des Moines on a Friday will generally be more expensive and average around $200. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from Fort Myers to Des Moines in the evening for as low as $122. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $491. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Fort Myers to Des Moines.

How have Fort Myers to Des Moines flight prices changed over time?

As of August 2026, prices for Fort Myers to Des Moines flights are approximately 0% more expensive when compared to flights at the same time last year.

When to book flights from Fort Myers to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Best Price Found

$108

Fastest flight time

3h 12m

Direct flights

Tue and Sat

Airports in Des Moines

1 airport
The best flight deal from Fort Myers to Des Moines found on momondo in the last 72 hours is $108
The fastest flight from Fort Myers to Des Moines takes 3h 12m
Direct flights go from Fort Myers to Des Moines on Tuesday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Des Moines. From Fort Myers there are direct flights to Des Moines (DSM).
Search flight deals

Frequently asked questions about flying from Fort Myers to Des Moines

  • How far is Fort Myers SW Florida Intl to Des Moines by plane?

    A flight from Fort Myers SW Florida Intl to Des Moines will travel around 1228.7 mi. Typically, this will take 3h 12m by plane in normal conditions.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Fort Myers to Des Moines?

  • What is the most popular airline from Fort Myers to Des Moines?

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $100Free CancellationRating
7.3
677 reviews
Search Allegiant Air flights
DeltaPriceFrom $152Free CancellationRating
7.8
8,509 reviews
Search Delta flights
American AirlinesPriceFrom $236Free CancellationRating
7.1
11,939 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Urbandale
Newton
Osceola
Johnston
Boone
Oskaloosa
Norwalk
Grinnell
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

It is quick and easy to find Fort Myers to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Fort Myers which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Fort Myers to Des Moines?

Once you have performed a search for Fort Myers to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Fort Myers to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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