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Cheap flights from Fort Myers to Des Moines from $45

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Fort Myers to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:53 pm - 10:08 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
3h 15mnonstop
Multiple Airlines Logo
8:43 am - 11:50 amDSM  Des Moines-RSW Fort Myers SW Florida Intl
26h 07m1 stop Philadelphia
$220Multiple Airlines
Fri, Oct 16 - Sun, Oct 18
Delta Logo
4:15 pm - 8:52 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
5h 37m1 stop Detroit Metropolitan Wayne County
Delta Logo
10:15 am - 5:22 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
6h 07m1 stop Detroit Metropolitan Wayne County
$339Delta
Wed, Jan 13 - Tue, Jan 19
United Airlines Logo
9:10 am - 2:26 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
6h 16m1 stop Chicago O'Hare Intl
United Airlines Logo
8:00 am - 2:49 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
5h 49m1 stop Chicago O'Hare Intl
$339United Airlines
Wed, Oct 28 - Thu, Oct 29
United Airlines Logo
4:45 pm - 9:55 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
6h 10m1 stop Chicago O'Hare Intl
United Airlines Logo
8:00 am - 2:49 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
5h 49m1 stop Chicago O'Hare Intl
$339United Airlines
Mon, Oct 26 - Thu, Oct 29
Delta Logo
2:43 pm - 7:15 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
5h 32m1 stop Minneapolis St Paul
Delta Logo
4:17 pm - 11:34 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
6h 17m1 stop Atlanta Hartsfield-Jackson
$339Delta
Tue, Nov 10 - Thu, Nov 26
Delta Logo
4:10 pm - 9:24 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
6h 14m1 stop Minneapolis St Paul
Delta Logo
5:15 pm - 12:35 amDSM  Des Moines-RSW Fort Myers SW Florida Intl
6h 20m1 stop Atlanta Hartsfield-Jackson
$339Delta
Wed, Jan 13 - Tue, Jan 19
American Airlines Logo
8:15 am - 1:28 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
6h 13m1 stop Chicago O'Hare Intl
American Airlines Logo
9:25 am - 6:50 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
8h 25m1 stop Chicago O'Hare Intl
$364American Airlines
Wed, Nov 4 - Fri, Nov 6
American Airlines Logo
6:24 pm - 11:26 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
6h 02m1 stop Charlotte Douglas
American Airlines Logo
3:31 pm - 10:12 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
5h 41m1 stop Dallas/Fort Worth
$364American Airlines
Wed, Nov 4 - Fri, Nov 6
American Airlines Logo
11:11 am - 7:13 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
9h 02m2 stops Charlotte Douglas Chicago O'Hare Intl
American Airlines Logo
2:39 pm - 11:16 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
7h 37m1 stop Chicago O'Hare Intl
$367American Airlines
Wed, Jan 13 - Tue, Jan 19
Allegiant Air Logo
7:38 pm - 9:53 pmRSW  Fort Myers SW Florida Intl-DSM Des Moines
3h 15mnonstop
Allegiant Air Logo
3:04 pm - 7:03 pmDSM  Des Moines-RSW Fort Myers SW Florida Intl
2h 59mnonstop
$377Allegiant Air
Mon, Oct 12 - Fri, Oct 16

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Delta flights from Fort Myers to Des Moines

Our best Delta deals on Fort Myers to Des Moines flight tickets
Delta
Jan 13
RSW4:15 pmFort Myers SW Florida Intl
5h 37m
1 stop
DSM8:52 pmDes Moines
Jan 19
DSM10:15 amDes Moines
6h 07m
1 stop
RSW5:22 pmFort Myers SW Florida Intl
$339
Delta
Oct 10
RSW2:15 pmFort Myers SW Florida Intl
7h 25m
1 stop
DSM8:40 pmDes Moines
Oct 14
DSM5:35 amDes Moines
5h 32m
1 stop
RSW12:07 pmFort Myers SW Florida Intl
$537
Delta
Oct 3
RSW6:19 pmFort Myers SW Florida Intl
5h 07m
1 stop
DSM10:26 pmDes Moines
Oct 7
DSM11:27 amDes Moines
6h 23m
1 stop
RSW6:50 pmFort Myers SW Florida Intl
$907

United Airlines flights from Fort Myers to Des Moines

Our best United Airlines deals on Fort Myers to Des Moines flight tickets
United Airlines
Oct 28
RSW8:30 amFort Myers SW Florida Intl
9h 57m
2 stops
DSM5:27 pmDes Moines
Oct 29
DSM9:50 amDes Moines
6h 12m
1 stop
RSW5:02 pmFort Myers SW Florida Intl
$344
United Airlines
Nov 4
RSW2:21 pmFort Myers SW Florida Intl
5h 55m
1 stop
DSM7:16 pmDes Moines
Nov 6
DSM1:27 pmDes Moines
7h 29m
1 stop
RSW9:56 pmFort Myers SW Florida Intl
$364
United Airlines
Jan 21
RSW6:17 pmFort Myers SW Florida Intl
5h 59m
1 stop
DSM11:16 pmDes Moines
Jan 25
DSM1:02 pmDes Moines
5h 43m
1 stop
RSW7:45 pmFort Myers SW Florida Intl
$449

momondo Fare Finder

 
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

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Route

Depart

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Price

Cheapest round-trip

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Fri 10/16

7:53 pm-10:08 pm

Nonstop3h 15m

Des Moines

Sun 10/18

8:43 am-11:50 am

1 stop26h 07m

$220

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 1/13

4:15 pm-8:52 pm

1 stop5h 37m

Des Moines

Tue 1/19

10:15 am-5:22 pm

1 stop6h 07m

$339

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 10/28

9:10 am-2:26 pm

1 stop6h 16m

Des Moines

Thu 10/29

8:00 am-2:49 pm

1 stop5h 49m

$339

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Mon 10/26

4:45 pm-9:55 pm

1 stop6h 10m

Des Moines

Thu 10/29

8:00 am-2:49 pm

1 stop5h 49m

$339

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Tue 11/10

2:43 pm-7:15 pm

1 stop5h 32m

Des Moines

Thu 11/26

4:17 pm-11:34 pm

1 stop6h 17m

$339

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 1/13

4:10 pm-9:24 pm

1 stop6h 14m

Des Moines

Tue 1/19

5:15 pm-12:35 am

1 stop6h 20m

$339

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 11/4

8:15 am-1:28 pm

1 stop6h 13m

Des Moines

Fri 11/6

9:25 am-6:50 pm

1 stop8h 25m

$364

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 11/4

6:24 pm-11:26 pm

1 stop6h 02m

Des Moines

Fri 11/6

3:31 pm-10:12 pm

1 stop5h 41m

$364

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Wed 1/13

11:11 am-7:13 pm

2 stops9h 02m

Des Moines

Tue 1/19

2:39 pm-11:16 pm

1 stop7h 37m

$367
Quickest round-trip

Fort MyersDes Moines

RSW Fort Myers SW Florida Intl - DSM Des Moines

RSWDSM

Fort Myers SW Florida Intl

Mon 10/12

7:38 pm-9:53 pm

Nonstop3h 15m

Des Moines

Fri 10/16

3:04 pm-7:03 pm

Nonstop2h 59m

$377

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Fort Myers and Des Moines?

Prices are currently typical for flights on this route.

Typical prices usually range from $187 to $495.
The lowest price recently found on this route was $220.

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then January is your next best option. Flight prices from Fort Myers to Des Moines during January average around $200.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Fort Myers to Des Moines is on a Friday. Travelers who choose to depart for Des Moines on a Friday will often find tickets for as low as $140. Flights from Fort Myers to Des Moines on a Monday will generally be more expensive and average around $189. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the evening. momondo users have found flights departing from Fort Myers to Des Moines in the evening for as low as $122. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $491. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Fort Myers to Des Moines.

How have Fort Myers to Des Moines flight prices changed over time?

As of September 2026, prices for Fort Myers to Des Moines flights are approximately 55% cheaper when compared to flights at the same time last year.

When to book flights from Fort Myers to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Best Price Found

$45

Fastest flight time

3h 15m

Direct flights

Mon, Tue and Sat

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Fort Myers in the past 72 hours is $45. The best round-trip flight deal from Fort Myers to Des Moines found on momondo in the last 72 hours is $220.
The fastest flight from Fort Myers to Des Moines takes 3h 15m
Direct flights go from Fort Myers to Des Moines on Monday, Tuesday and Saturday. The only airline offering direct flights is Allegiant Air.
There is 1 airport in Des Moines. From Fort Myers there are direct flights to Des Moines (DSM).
Search flight deals

Frequently asked questions about flying from Fort Myers to Des Moines

  • How far is Fort Myers SW Florida Intl to Des Moines by plane?

    A flight from Fort Myers SW Florida Intl to Des Moines will travel around 1228.7 mi. Typically, this will take 3h 15m by plane in normal conditions.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Fort Myers to Des Moines?

  • What is the most popular airline from Fort Myers to Des Moines?

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $94Free CancellationRating
7.3
678 reviews
Search Allegiant Air flights
DeltaPriceFrom $152Free CancellationRating
7.8
8,606 reviews
Search Delta flights
American AirlinesPriceFrom $236Free CancellationRating
7.0
12,097 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Clive
Altoona
Pella
Osceola
Urbandale
Newton
Boone
Johnston
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

It is quick and easy to find Fort Myers to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Fort Myers which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Fort Myers to Des Moines?

Once you have performed a search for Fort Myers to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Fort Myers to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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