What is the cheapest airline that flies from Fort Myers SW Florida Intl to Des Moines?

Allegiant Air, American Airlines, and Delta are the most popular carriers operating from Fort Myers SW Florida Intl to Des Moines

What airlines fly to Des Moines?

American Airlines, Delta and Allegiant Air are the top three most popular airlines that fly to Des Moines from Fort Myers according to our data. American Airlines is the first choice among our users, with 28% of people opting to fly with this airline when traveling to Des Moines. Keep in mind that there are 4 different airlines that fly to Des Moines on a routine basis, so you have a few additional options to choose from.

When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.

How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

As of October 2025, there are 2 operators available to choose from for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport.

How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.

What documentation or ID do you need to fly to Des Moines Airport?

The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$72 Cheap Flights from Fort Myers to Des Moines in 2025/26

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Cheap round-trip flights

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6:50 pm - 9:09 pmRSW-DSM

3h 19mnonstop

1:56 pm - 6:00 pmDSM-RSW

3h 04mnonstop

$268Allegiant Air

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Fri, Nov 21 - Mon, Dec 29

6:50 pm - 9:09 pmRSW-DSM

3h 19mnonstop

6:41 pm - 12:50 amDSM-RSW

53h 09m2 stops

$285Multiple Airlines

Find Deal

Fri, Nov 21 - Tue, Dec 30

8:05 am - 1:42 pmRSW-DSM

6h 37m1 stop

5:00 am - 12:15 pmDSM-RSW

6h 15m1 stop

$309American Airlines

Find Deal

Thu, Nov 27 - Thu, Dec 4

6:00 am - 2:19 pmRSW-DSM

9h 19m2 stops

8:00 am - 2:46 pmDSM-RSW

5h 46m1 stop

$347United Airlines

Find Deal

Thu, Nov 27 - Thu, Dec 4

2:03 pm - 10:02 pmRSW-DSM

8h 59m1 stop

3:32 pm - 12:48 amDSM-RSW

8h 16m2 stops

$363American Airlines

Find Deal

Wed, Nov 19 - Sat, Nov 22

7:50 am - 11:25 amRSW-DSM

4h 35m1 stop

6:45 pm - 12:10 amDSM-RSW

4h 25m1 stop

$378Southwest

Find Deal

Wed, Nov 19 - Sat, Nov 22

11:59 am - 8:03 pmRSW-DSM

9h 04m1 stop

5:15 pm - 11:04 pmDSM-RSW

4h 49m1 stop

$407Delta

Find Deal

Thu, Mar 5 - Mon, Mar 9

11:59 am - 8:03 pmRSW-DSM

9h 04m1 stop

5:15 pm - 12:37 amDSM-RSW

6h 22m1 stop

$417Delta

Find Deal

Thu, Mar 5 - Mon, Mar 9

12:30 pm - 7:55 pmRSW-DSM

8h 25m1 stop

6:45 pm - 12:10 amDSM-RSW

4h 25m1 stop

$453Southwest

Find Deal

Wed, Nov 19 - Sat, Nov 22

1:51 pm - 9:50 pmRSW-DSM

8h 59m2 stops

8:00 am - 8:29 pmDSM-RSW

11h 29m2 stops

$497United Airlines

Find Deal

Thu, Mar 5 - Mon, Mar 9

American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets

American Airlines

Nov 27

RSW8:05 amFort Myers SW Florida Intl

6h 37m

1 stop

DSM1:42 pmDes Moines

Dec 4

DSM5:00 amDes Moines

6h 15m

1 stop

RSW12:15 pmFort Myers SW Florida Intl

$309

Find similar

American Airlines

Nov 19

RSW2:03 pmFort Myers SW Florida Intl

8h 59m

1 stop

DSM10:02 pmDes Moines

Nov 22

DSM3:32 pmDes Moines

8h 16m

2 stops

RSW12:48 amFort Myers SW Florida Intl

$363

Find similar

American Airlines

Nov 19

RSW8:40 amFort Myers SW Florida Intl

7h 52m

2 stops

DSM3:32 pmDes Moines

Nov 22

DSM3:32 pmDes Moines

8h 16m

2 stops

RSW12:48 amFort Myers SW Florida Intl

$368

Find similar

United Airlines flights from Fort Myers to Des Moines

Our best United Airlines deals on Fort Myers to Des Moines flight tickets

United Airlines

Nov 27

RSW6:00 amFort Myers SW Florida Intl

9h 19m

2 stops

DSM2:19 pmDes Moines

Dec 4

DSM8:00 amDes Moines

5h 46m

1 stop

RSW2:46 pmFort Myers SW Florida Intl

$347

Find similar

United Airlines

Mar 5

RSW1:51 pmFort Myers SW Florida Intl

8h 59m

2 stops

DSM9:50 pmDes Moines

Mar 9

DSM8:00 amDes Moines

11h 29m

2 stops

RSW8:29 pmFort Myers SW Florida Intl

$497

Find similar

United Airlines

Nov 27

RSW6:00 amFort Myers SW Florida Intl

9h 19m

2 stops

DSM2:19 pmDes Moines

Dec 4

DSM6:50 pmDes Moines

15h 00m

2 stops

RSW10:50 amFort Myers SW Florida Intl

$509

Find similar

Fly from

Fly to

Route

Depart

Return

Price

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 11/21

6:50 pm-9:09 pm

Nonstop3h 19m

Des Moines

Mon 12/29

1:56 pm-6:00 pm

Nonstop3h 04m

$268

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 11/21

6:50 pm-9:09 pm

Nonstop3h 19m

Des Moines

Tue 12/30

6:41 pm-12:50 am

2 stops53h 09m

$285

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 11/27

8:05 am-1:42 pm

1 stop6h 37m

Des Moines

Thu 12/4

5:00 am-12:15 pm

1 stop6h 15m

$309

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 11/27

6:00 am-2:19 pm

2 stops9h 19m

Des Moines

Thu 12/4

8:00 am-2:46 pm

1 stop5h 46m

$347

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 11/19

2:03 pm-10:02 pm

1 stop8h 59m

Des Moines

Sat 11/22

3:32 pm-12:48 am

2 stops8h 16m

$363

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 11/19

7:50 am-11:25 am

1 stop4h 35m

Des Moines

Sat 11/22

6:45 pm-12:10 am

1 stop4h 25m

$378

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 3/5

11:59 am-8:03 pm

1 stop9h 04m

Des Moines

Mon 3/9

5:15 pm-11:04 pm

1 stop4h 49m

$407

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 3/5

11:59 am-8:03 pm

1 stop9h 04m

Des Moines

Mon 3/9

5:15 pm-12:37 am

1 stop6h 22m

$417

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Wed 11/19

12:30 pm-7:55 pm

1 stop8h 25m

Des Moines

Sat 11/22

6:45 pm-12:10 am

1 stop4h 25m

$453

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 3/5

1:51 pm-9:50 pm

2 stops8h 59m

Des Moines

Mon 3/9

8:00 am-8:29 pm

2 stops11h 29m

$497

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in August, then September is your next best option. Flight prices from Fort Myers to Des Moines during September average around $346.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Fort Myers to Des Moines is on a Saturday. Travelers who choose to depart for Des Moines on a Saturday will often find tickets for as low as $406. Flights from Fort Myers to Des Moines on a Tuesday will generally be more expensive and average around $462. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is at noon. momondo users have found flights departing from Fort Myers to Des Moines at noon for as low as $407. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $503. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers SW Florida Intl to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers SW Florida Intl to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

You could potentially save up to 16% on your flight if you consider stops on a Fort Myers to Des Moines flight.

How have Fort Myers to Des Moines flight prices changed over time?

When to book flights from Fort Myers to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Des Moines according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Fastest flight time	3h 19m
Direct flights	Tue and Sat
Airports in Des Moines	1 airport

The fastest flight from Fort Myers to Des Moines takes 3h 19m

Direct flights go from Fort Myers to Des Moines on Tuesday and Saturday. There are no airlines offering direct flights.

There is 1 airport near Des Moines: Des Moines (DSM)

Search flight deals

How far is Fort Myers SW Florida Intl to Des Moines by plane?
A flight from Fort Myers SW Florida Intl to Des Moines will travel around 1228.7 mi. Typically, this will take 3h 19m by plane in normal conditions.
When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?
Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.
How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?
As of October 2025, there are 2 operators available to choose from for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport.
How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.
What documentation or ID do you need to fly to Des Moines Airport?
The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Fort Myers to Des Moines?
Based on momondo bookings for this flight route, the most popular plane model on flight routes from Fort Myers to Des Moines is Airbus A320-100/200 (100.00% of total bookings).
What is the most popular airline from Fort Myers to Des Moines?
Based on momondo bookings for flights between Fort Myers and Des Moines, the leading airline is Southwest, making up 66% of the total bookings. Other popular airlines include American Airlines with 34%.

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo

Airline	Rating	Free Cancellation	Price
American Airlines	PriceFrom $266	Free Cancellation	Rating 7.2 11,035 reviews		Search American Airlines flights
Southwest	PriceFrom $366	Free Cancellation	Rating 8.0 4,243 reviews		Search Southwest flights

West Des Moines

Ames

Ankeny

Altoona

Urbandale

Clive

Pella

Newton

Johnston

Osceola

Boone

Norwalk

Grinnell

Oskaloosa

Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

It is quick and easy to find Fort Myers to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Fort Myers which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Fort Myers to Des Moines?

Once you have performed a search for Fort Myers to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Fort Myers to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

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Cheap flights from Fort Myers to Des Moines from $72

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Des Moines departing on 12/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.

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American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets

United Airlines flights from Fort Myers to Des Moines

Our best United Airlines deals on Fort Myers to Des Moines flight tickets

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Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

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How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in August, then September is your next best option. Flight prices from Fort Myers to Des Moines during September average around $346.

What is the cheapest day to depart on your flight to Des Moines?

What is the cheapest time of day to depart on your flight to Des Moines?

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers SW Florida Intl to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers SW Florida Intl to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

You could potentially save up to 16% on your flight if you consider stops on a Fort Myers to Des Moines flight.

How have Fort Myers to Des Moines flight prices changed over time?

What is the cheapest airline that flies from Fort Myers SW Florida Intl to Des Moines?

Allegiant Air, American Airlines, and Delta are the most popular carriers operating from Fort Myers SW Florida Intl to Des Moines

What airlines fly to Des Moines?

When to book flights from Fort Myers to Des Moines

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Fastest flight time

Direct flights

Airports in Des Moines

How far is Fort Myers SW Florida Intl to Des Moines by plane?

When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

What documentation or ID do you need to fly to Des Moines Airport?

What is the most popular plane model from Fort Myers to Des Moines?

What is the most popular airline from Fort Myers to Des Moines?

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo

Traveling to a place near Des Moines?

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

How can momondo help me find flights from Fort Myers to Des Moines?

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

An easier way to manage your Des Moines trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to the United States

Airports servicing Iowa