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Cheap flights from Fort Myers to Des Moines from $170

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Des Moines departing on 5/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Fort Myers to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
6:30 pm - 10:37 pm
RSW
-
DSM
5h 07m
1 stop
Delta Logo
5:40 am - 2:24 pm
DSM
-
RSW
7h 44m
1 stop
$339Delta
Tue, Aug 11 - Tue, Aug 18
American Airlines Logo
12:47 pm - 8:18 pm
RSW
-
DSM
8h 31m
1 stop
American Airlines Logo
6:11 am - 3:09 pm
DSM
-
RSW
7h 58m
2 stops
$344American Airlines
Tue, Jul 7 - Thu, Jul 9
American Airlines Logo
5:44 pm - 11:28 pm
RSW
-
DSM
6h 44m
2 stops
American Airlines Logo
5:00 am - 2:57 pm
DSM
-
RSW
8h 57m
2 stops
$349American Airlines
Thu, Sep 10 - Wed, Sep 16
American Airlines Logo
6:01 am - 12:52 pm
RSW
-
DSM
7h 51m
1 stop
American Airlines Logo
6:02 am - 3:06 pm
DSM
-
RSW
8h 04m
2 stops
$376American Airlines
Sat, Jun 13 - Wed, Jun 17
Delta Logo
6:45 am - 10:43 am
RSW
-
DSM
4h 58m
1 stop
Delta Logo
6:39 pm - 1:02 am
DSM
-
RSW
5h 23m
1 stop
$383Delta
Fri, Jun 12 - Wed, Jun 17
American Airlines Logo
5:26 pm - 12:08 am
RSW
-
DSM
7h 42m
1 stop
American Airlines Logo
6:30 am - 1:24 pm
DSM
-
RSW
5h 54m
1 stop
$389American Airlines
Mon, Jun 1 - Thu, Jun 4
American Airlines Logo
3:57 pm - 12:08 am
RSW
-
DSM
9h 11m
2 stops
American Airlines Logo
6:30 am - 1:24 pm
DSM
-
RSW
5h 54m
1 stop
$395American Airlines
Mon, Jun 1 - Thu, Jun 4
Delta Logo
1:19 pm - 5:48 pm
RSW
-
DSM
5h 29m
1 stop
Delta Logo
4:11 pm - 12:40 am
DSM
-
RSW
7h 29m
1 stop
$409Delta
Thu, Aug 13 - Sat, Aug 15
American Airlines Logo
3:57 pm - 12:08 am
RSW
-
DSM
9h 11m
2 stops
American Airlines Logo
5:00 am - 3:06 pm
DSM
-
RSW
9h 06m
2 stops
$411American Airlines
Mon, Jun 1 - Thu, Jun 4
Delta Logo
6:30 pm - 10:37 pm
RSW
-
DSM
5h 07m
1 stop
Delta Logo
5:40 am - 12:13 pm
DSM
-
RSW
5h 33m
1 stop
$419Delta
Fri, Aug 14 - Tue, Aug 18

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United Airlines flights from Fort Myers to Des Moines

Our best United Airlines deals on Fort Myers to Des Moines flight tickets
United Airlines
Aug 18
RSW12:30 pmFort Myers SW Florida Intl
7h 54m
1 stop
DSM7:24 pmDes Moines
Aug 19
DSM6:00 amDes Moines
7h 41m
1 stop
RSW2:41 pmFort Myers SW Florida Intl
$429
United Airlines
Aug 18
RSW9:28 amFort Myers SW Florida Intl
5h 37m
1 stop
DSM2:05 pmDes Moines
Aug 19
DSM5:50 amDes Moines
9h 02m
2 stops
RSW3:52 pmFort Myers SW Florida Intl
$434
United Airlines
Aug 13
RSW9:28 amFort Myers SW Florida Intl
5h 37m
1 stop
DSM2:05 pmDes Moines
Aug 16
DSM5:00 amDes Moines
8h 41m
1 stop
RSW2:41 pmFort Myers SW Florida Intl
$473

American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets
American Airlines
Jul 7
RSW12:47 pmFort Myers SW Florida Intl
8h 31m
1 stop
DSM8:18 pmDes Moines
Jul 9
DSM6:11 amDes Moines
7h 58m
2 stops
RSW3:09 pmFort Myers SW Florida Intl
$344
American Airlines
Sep 10
RSW5:44 pmFort Myers SW Florida Intl
6h 44m
2 stops
DSM11:28 pmDes Moines
Sep 16
DSM5:00 amDes Moines
8h 57m
2 stops
RSW2:57 pmFort Myers SW Florida Intl
$349
American Airlines
Jun 13
RSW6:01 amFort Myers SW Florida Intl
7h 51m
1 stop
DSM12:52 pmDes Moines
Jun 17
DSM6:02 amDes Moines
8h 04m
2 stops
RSW3:06 pmFort Myers SW Florida Intl
$376

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 8/11

6:30 pm-10:37 pm

1 stop5h 07m

Des Moines

Tue 8/18

5:40 am-2:24 pm

1 stop7h 44m

$339

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 7/7

12:47 pm-8:18 pm

1 stop8h 31m

Des Moines

Thu 7/9

6:11 am-3:09 pm

2 stops7h 58m

$344

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 9/10

5:44 pm-11:28 pm

2 stops6h 44m

Des Moines

Wed 9/16

5:00 am-2:57 pm

2 stops8h 57m

$349

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Sat 6/13

6:01 am-12:52 pm

1 stop7h 51m

Des Moines

Wed 6/17

6:02 am-3:06 pm

2 stops8h 04m

$376
Quickest round-trip

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 6/12

6:45 am-10:43 am

1 stop4h 58m

Des Moines

Wed 6/17

6:39 pm-1:02 am

1 stop5h 23m

$383

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 6/1

5:26 pm-12:08 am

1 stop7h 42m

Des Moines

Thu 6/4

6:30 am-1:24 pm

1 stop5h 54m

$389

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 6/1

3:57 pm-12:08 am

2 stops9h 11m

Des Moines

Thu 6/4

6:30 am-1:24 pm

1 stop5h 54m

$395

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 8/13

1:19 pm-5:48 pm

1 stop5h 29m

Des Moines

Sat 8/15

4:11 pm-12:40 am

1 stop7h 29m

$409

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 6/1

3:57 pm-12:08 am

2 stops9h 11m

Des Moines

Thu 6/4

5:00 am-3:06 pm

2 stops9h 06m

$411

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Fri 8/14

6:30 pm-10:37 pm

1 stop5h 07m

Des Moines

Tue 8/18

5:40 am-12:13 pm

1 stop5h 33m

$419

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Fort Myers and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in December, then January is your next best option. Flight prices from Fort Myers to Des Moines during January average around $200.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Fort Myers to Des Moines is on a Monday. Travelers who choose to depart for Des Moines on a Monday will often find tickets for as low as $189. Flights from Fort Myers to Des Moines on a Friday will generally be more expensive and average around $200. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Fort Myers to Des Moines in the afternoon for as low as $165. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $491. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

Can stopping save me money on Fort Myers to Des Moines flights?

You could potentially save up to 6% on your flight if you consider stops on a Fort Myers to Des Moines flight.

How have Fort Myers to Des Moines flight prices changed over time?

When to book flights from Fort Myers to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Fastest flight time

4h 45m

Direct flights

None
The fastest flight from Fort Myers to Des Moines takes 4h 45m
There are no direct flights from Fort Myers to Des Moines. There are no popular flight routes from Fort Myers to Des Moines.
Search flight deals

Frequently asked questions about flying from Fort Myers to Des Moines

  • How far is Fort Myers SW Florida Intl to Des Moines by plane?

    A flight from Fort Myers SW Florida Intl to Des Moines will travel around 1228.7 mi. Typically, this will take 4h 45m by plane in normal conditions.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Fort Myers to Des Moines?

  • What is the most popular airline from Fort Myers to Des Moines?

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $100Free CancellationRating
7.3
707 reviews
Search Allegiant Air flights
DeltaPriceFrom $152Free CancellationRating
7.9
8,459 reviews
Search Delta flights
American AirlinesPriceFrom $236Free CancellationRating
7.1
11,668 reviews
Search American Airlines flights

  • Allegiant Air Flights From Fort Myers to Des Moines

    Allegiant Air operates around 2 flights from Fort Myers to Des Moines every week. The average price of these flights found in the last 72 hours has been $200, but momondo users have found Allegiant Air deals from Fort Myers to Des Moines from as low as $100 round-trip. Allegiant Air has been scored 7.3/10 in 707 reviews.

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Urbandale
Pella
Johnston
Newton
Osceola
Boone
Grinnell
Oskaloosa
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

It is quick and easy to find Fort Myers to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Fort Myers which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Fort Myers to Des Moines?

Once you have performed a search for Fort Myers to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Fort Myers to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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