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Cheap flights from Fort Myers to Des Moines from $167

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Fort Myers to Des Moines departing on 7/28. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Fort Myers to Des Moines

Cheap round-trip flights

Enter your travel dates to find the best prices.
Delta Logo
8:03 am - 1:34 pm
RSW
-
DSM
6h 31m
1 stop
Delta Logo
2:45 pm - 10:54 pm
DSM
-
RSW
7h 09m
1 stop
$333Delta
Tue, Jul 14 - Tue, Jul 21
Southwest Logo
1:05 pm - 10:50 pm
RSW
-
DSM
10h 45m
2 stops
Southwest Logo
3:45 pm - 10:45 pm
DSM
-
RSW
6h 00m
1 stop
$338Southwest
Tue, Jul 21 - Wed, Jul 29
Southwest Logo
1:05 pm - 10:50 pm
RSW
-
DSM
10h 45m
2 stops
Southwest Logo
5:20 am - 4:40 pm
DSM
-
RSW
10h 20m
2 stops
$343Southwest
Tue, Jul 21 - Wed, Jul 29
American Airlines Logo
6:22 pm - 11:58 pm
RSW
-
DSM
6h 36m
1 stop
American Airlines Logo
6:11 am - 3:09 pm
DSM
-
RSW
7h 58m
2 stops
$359American Airlines
Tue, Jul 14 - Tue, Jul 21
American Airlines Logo
6:22 am - 12:56 pm
RSW
-
DSM
7h 34m
1 stop
American Airlines Logo
1:41 pm - 8:33 pm
DSM
-
RSW
5h 52m
1 stop
$390American Airlines
Thu, Jul 16 - Wed, Jul 22
American Airlines Logo
12:47 pm - 8:18 pm
RSW
-
DSM
8h 31m
1 stop
American Airlines Logo
6:11 am - 3:09 pm
DSM
-
RSW
7h 58m
2 stops
$395American Airlines
Tue, Jul 7 - Thu, Jul 9
Southwest Logo
6:00 am - 3:05 pm
RSW
-
DSM
10h 05m
2 stops
Southwest Logo
5:20 am - 4:40 pm
DSM
-
RSW
10h 20m
2 stops
$400Southwest
Tue, Jul 14 - Tue, Jul 21
American Airlines Logo
8:05 am - 3:33 pm
RSW
-
DSM
8h 28m
1 stop
American Airlines Logo
6:00 am - 1:21 pm
DSM
-
RSW
6h 21m
1 stop
$401American Airlines
Mon, Nov 16 - Mon, Nov 23
American Airlines Logo
4:44 pm - 11:44 pm
RSW
-
DSM
8h 00m
1 stop
American Airlines Logo
4:02 pm - 12:27 am
DSM
-
RSW
7h 25m
2 stops
$406American Airlines
Mon, Nov 16 - Mon, Nov 23
American Airlines Logo
5:24 pm - 12:01 am
RSW
-
DSM
7h 37m
1 stop
American Airlines Logo
5:00 am - 3:09 pm
DSM
-
RSW
9h 09m
2 stops
$416American Airlines
Thu, Jul 16 - Wed, Jul 22

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United Airlines flights from Fort Myers to Des Moines

Our best United Airlines deals on Fort Myers to Des Moines flight tickets
United Airlines
Nov 17
RSW8:00 amFort Myers SW Florida Intl
9h 14m
1 stop
DSM4:14 pmDes Moines
Nov 18
DSM5:00 amDes Moines
5h 30m
1 stop
RSW11:30 amFort Myers SW Florida Intl
$423
United Airlines
Nov 17
RSW2:25 pmFort Myers SW Florida Intl
7h 52m
1 stop
DSM9:17 pmDes Moines
Nov 18
DSM5:00 amDes Moines
11h 39m
2 stops
RSW5:39 pmFort Myers SW Florida Intl
$428
United Airlines
Nov 17
RSW12:00 pmFort Myers SW Florida Intl
10h 17m
2 stops
DSM9:17 pmDes Moines
Nov 18
DSM8:00 amDes Moines
11h 01m
2 stops
RSW8:01 pmFort Myers SW Florida Intl
$433

American Airlines flights from Fort Myers to Des Moines

Our best American Airlines deals on Fort Myers to Des Moines flight tickets
American Airlines
Jul 14
RSW6:22 pmFort Myers SW Florida Intl
6h 36m
1 stop
DSM11:58 pmDes Moines
Jul 21
DSM6:11 amDes Moines
7h 58m
2 stops
RSW3:09 pmFort Myers SW Florida Intl
$359
American Airlines
Nov 16
RSW8:05 amFort Myers SW Florida Intl
8h 28m
1 stop
DSM3:33 pmDes Moines
Nov 23
DSM6:00 amDes Moines
6h 21m
1 stop
RSW1:21 pmFort Myers SW Florida Intl
$401
American Airlines
Nov 16
RSW4:44 pmFort Myers SW Florida Intl
8h 00m
1 stop
DSM11:44 pmDes Moines
Nov 23
DSM4:02 pmDes Moines
7h 25m
2 stops
RSW12:27 amFort Myers SW Florida Intl
$406

momondo Fare Finder

 
Customize your flight search to find flights from Fort Myers to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated June 21, 2026.
Use the filters below to find and compare flights from Fort Myers to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 7/14

8:03 am-1:34 pm

1 stop6h 31m

Des Moines

Tue 7/21

2:45 pm-10:54 pm

1 stop7h 09m

$333

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 7/21

1:05 pm-10:50 pm

2 stops10h 45m

Des Moines

Wed 7/29

3:45 pm-10:45 pm

1 stop6h 00m

$338

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 7/21

1:05 pm-10:50 pm

2 stops10h 45m

Des Moines

Wed 7/29

5:20 am-4:40 pm

2 stops10h 20m

$343

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 7/14

6:22 pm-11:58 pm

1 stop6h 36m

Des Moines

Tue 7/21

6:11 am-3:09 pm

2 stops7h 58m

$359
Quickest round-trip

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 7/16

6:22 am-12:56 pm

1 stop7h 34m

Des Moines

Wed 7/22

1:41 pm-8:33 pm

1 stop5h 52m

$390

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 7/7

12:47 pm-8:18 pm

1 stop8h 31m

Des Moines

Thu 7/9

6:11 am-3:09 pm

2 stops7h 58m

$395

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Tue 7/14

6:00 am-3:05 pm

2 stops10h 05m

Des Moines

Tue 7/21

5:20 am-4:40 pm

2 stops10h 20m

$400

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 11/16

8:05 am-3:33 pm

1 stop8h 28m

Des Moines

Mon 11/23

6:00 am-1:21 pm

1 stop6h 21m

$401

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Mon 11/16

4:44 pm-11:44 pm

1 stop8h 00m

Des Moines

Mon 11/23

4:02 pm-12:27 am

2 stops7h 25m

$406

Fort MyersDes Moines

RSW - DSM

RSWDSM

Fort Myers SW Florida Intl

Thu 7/16

5:24 pm-12:01 am

1 stop7h 37m

Des Moines

Wed 7/22

5:00 am-3:09 pm

2 stops9h 09m

$416

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Des Moines from

How to get the cheapest flight ticket from Fort Myers to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Fort Myers and Des Moines?

What is the cheapest month to fly to Des Moines?

If you’re not able to fly to Des Moines in August, then December is your next best option. Flight prices from Fort Myers to Des Moines during December average around $189.

What is the cheapest day to depart on your flight to Des Moines?

The cheapest day to depart from Fort Myers to Des Moines is on a Monday. Travelers who choose to depart for Des Moines on a Monday will often find tickets for as low as $189. Flights from Fort Myers to Des Moines on a Friday will generally be more expensive and average around $202. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Des Moines?

According to our data, the cheapest time of day to fly to Des Moines is in the afternoon. momondo users have found flights departing from Fort Myers to Des Moines in the afternoon for as low as $165. Keep in mind that these prices may fluctuate based on what airline you choose and the time of year you plan to travel. Try not to purchase tickets in the morning because they tend to be around $491. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Fort Myers SW Florida Intl to Des Moines flight route?

Fly from Fort Myers SW Florida Intl to Des Moines for the best Fort Myers SW Florida Intl - Des Moines flight prices

What cabin class options are available on Fort Myers to Des Moines flights?

There is only 1 cabin class available to choose from on Fort Myers to Des Moines flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Fort Myers to Des Moines flights?

No. A direct flight is the cheapest option for a flight between Fort Myers to Des Moines.

How have Fort Myers to Des Moines flight prices changed over time?

As of June 2026, prices for Fort Myers to Des Moines flights are approximately 2% cheaper when compared to flights at the same time last year.

When to book flights from Fort Myers to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Fort Myers to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Fort Myers to Des Moines (RSW to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Fort Myers to Des Moines

Fastest flight time

3h 15m

Direct flights

Tue

Airports in Des Moines

1 airport
The fastest flight from Fort Myers to Des Moines takes 3h 15m
Direct flights go from Fort Myers to Des Moines on Tuesday. There are no airlines offering direct flights.
There is 1 airport in Des Moines. From Fort Myers there are direct flights to Des Moines (DSM).
Search flight deals

Frequently asked questions about flying from Fort Myers to Des Moines

  • How far is Fort Myers SW Florida Intl to Des Moines by plane?

    A flight from Fort Myers SW Florida Intl to Des Moines will travel around 1228.7 mi. Typically, this will take 3h 15m by plane in normal conditions.

  • When did momondo last update prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    Prices for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Fort Myers SW Florida Intl Airport to Des Moines Airport?

  • How old do you have to be to fly from Fort Myers SW Florida Intl Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Fort Myers SW Florida Intl Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The required travel and health documents for your Des Moines Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Des Moines Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Fort Myers to Des Moines?

  • What is the most popular airline from Fort Myers to Des Moines?

Best airlines flying from Fort Myers to Des Moines

Compare and see reviews for airlines that fly from Fort Myers to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $100Free CancellationRating
7.3
692 reviews
Search Allegiant Air flights
DeltaPriceFrom $152Free CancellationRating
7.8
8,423 reviews
Search Delta flights
American AirlinesPriceFrom $236Free CancellationRating
7.1
11,726 reviews
Search American Airlines flights

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
West Des Moines
Ames
Ankeny
Altoona
Clive
Pella
Osceola
Urbandale
Newton
Johnston
Boone
Oskaloosa
Grinnell
Norwalk
Carlisle

Why use momondo?

Why should I use momondo to find a flight deal from Fort Myers to Des Moines?

It is quick and easy to find Fort Myers to Des Moines flights on momondo. We search and return numerous flight options from various airlines and agents. You can then use our filters to narrow your search until you have found the most convenient flight to Des Moines that suits you.

Can I find flights from Fort Myers to Des Moines with flexible booking policies on momondo?

momondo does allow users to show only those flights to Des Moines from Fort Myers which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Fort Myers to Des Moines?

Once you have performed a search for Fort Myers to Des Moines flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Fort Myers to Des Moines right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Fort Myers to Des Moines now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to Des Moines and let you know when they change.

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