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Cheap flights from Detroit to St. Louis from $60

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to St. Louis departing on 9/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to St. Louis

Cheap round-trip flights

Southwest Logo
8:55 am - 9:30 amDTW-STL
1h 35mnonstop
Southwest Logo
7:45 am - 10:15 amSTL-DTW
1h 30mnonstop
$154Southwest
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Thu, Sep 25 - Thu, Oct 2
Logo
7:20 am - 3:04 pmDTW-STL
8h 44m1 stop
Logo
4:00 pm - 9:59 amSTL-DTW
16h 59m1 stop
$156
Find Deal
Thu, Sep 18 - Thu, Sep 25
Frontier Logo
1:36 pm - 1:02 pmDTW-STL
24h 26m1 stop
Frontier Logo
4:00 pm - 2:46 pmSTL-DTW
21h 46m1 stop
$160Frontier
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Thu, Sep 4 - Sun, Sep 7
American Airlines Logo
12:24 pm - 8:32 pmDTW-STL
9h 08m1 stop
American Airlines Logo
6:10 am - 6:47 pmSTL-DTW
11h 37m1 stop
$171American Airlines
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Wed, Oct 1 - Sat, Oct 4
Frontier Logo
4:58 pm - 10:37 amDTW-STL
18h 39m1 stop
Frontier Logo
7:52 pm - 12:59 amSTL-DTW
28h 07m1 stop
$185Frontier
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Thu, Oct 16 - Tue, Oct 21
American Airlines Logo
7:21 pm - 11:53 pmDTW-STL
5h 32m1 stop
American Airlines Logo
7:23 am - 12:34 pmSTL-DTW
4h 11m1 stop
$187American Airlines
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Thu, Sep 25 - Sun, Sep 28
Delta Logo
4:37 pm - 5:15 pmDTW-STL
1h 38mnonstop
Delta Logo
2:15 pm - 4:45 pmSTL-DTW
1h 30mnonstop
$217Delta
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Tue, Oct 21 - Wed, Oct 22
Delta Logo
8:55 am - 9:33 amDTW-STL
1h 38mnonstop
Delta Logo
10:40 am - 1:13 pmSTL-DTW
1h 33mnonstop
$225Delta
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Wed, Oct 1 - Sat, Oct 4
Spirit Airlines Logo
6:41 am - 5:45 pmDTW-STL
12h 04m1 stop
Spirit Airlines Logo
10:57 am - 11:29 pmSTL-DTW
11h 32m1 stop
$226Spirit Airlines
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Sat, Oct 18 - Tue, Oct 21
Spirit Airlines Logo
7:20 am - 5:45 pmDTW-STL
11h 25m2 stops
Spirit Airlines Logo
10:57 am - 11:29 pmSTL-DTW
11h 32m1 stop
$246Spirit Airlines
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Sat, Oct 18 - Thu, Oct 23

American Airlines flights from Detroit to St. Louis

Our best American Airlines deals on Detroit to St. Louis flight tickets
American Airlines
Oct 1
DTW12:24 pmDetroit Metropolitan Wayne County
9h 08m
1 stop
STL8:32 pmLambert-St Louis
Oct 4
STL6:10 amLambert-St Louis
11h 37m
1 stop
DTW6:47 pmDetroit Metropolitan Wayne County
$171
Find similar
American Airlines
Sep 25
DTW7:21 pmDetroit Metropolitan Wayne County
5h 32m
1 stop
STL11:53 pmLambert-St Louis
Sep 28
STL7:23 amLambert-St Louis
4h 11m
1 stop
DTW12:34 pmDetroit Metropolitan Wayne County
$187
Find similar
American Airlines
Sep 11
DTW10:13 amDetroit Metropolitan Wayne County
6h 33m
1 stop
STL3:46 pmLambert-St Louis
Sep 20
STL6:29 amLambert-St Louis
5h 33m
1 stop
DTW1:02 pmDetroit Metropolitan Wayne County
$203
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Frontier flights from Detroit to St. Louis

Our best Frontier deals on Detroit to St. Louis flight tickets
Frontier
Sep 4
DTW1:36 pmDetroit Metropolitan Wayne County
24h 26m
1 stop
STL1:02 pmLambert-St Louis
Sep 7
STL4:00 pmLambert-St Louis
21h 46m
1 stop
DTW2:46 pmDetroit Metropolitan Wayne County
$160
Find similar
Frontier
Oct 16
DTW4:58 pmDetroit Metropolitan Wayne County
18h 39m
1 stop
STL10:37 amLambert-St Louis
Oct 21
STL7:52 pmLambert-St Louis
28h 07m
1 stop
DTW12:59 amDetroit Metropolitan Wayne County
$185
Find similar
Frontier
Sep 6
DTW8:00 amDetroit Metropolitan Wayne County
26h 06m
1 stop
STL9:06 amLambert-St Louis
Sep 7
STL4:00 pmLambert-St Louis
21h 46m
1 stop
DTW2:46 pmDetroit Metropolitan Wayne County
$194
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated August 21, 2025.
Use the filters below to find and compare flights from Detroit to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 9/25

8:55 am-9:30 am

Nonstop1h 35m

Lambert-St Louis

Thu 10/2

7:45 am-10:15 am

Nonstop1h 30m

$154

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 9/18

7:20 am-3:04 pm

1 stop8h 44m

Lambert-St Louis

Thu 9/25

4:00 pm-9:59 am

1 stop16h 59m

$156

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 9/4

1:36 pm-1:02 pm

1 stop24h 26m

Lambert-St Louis

Sun 9/7

4:00 pm-2:46 pm

1 stop21h 46m

$160

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/1

12:24 pm-8:32 pm

1 stop9h 08m

Lambert-St Louis

Sat 10/4

6:10 am-6:47 pm

1 stop11h 37m

$171

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/16

4:58 pm-10:37 am

1 stop18h 39m

Lambert-St Louis

Tue 10/21

7:52 pm-12:59 am

1 stop28h 07m

$185

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 9/25

7:21 pm-11:53 pm

1 stop5h 32m

Lambert-St Louis

Sun 9/28

7:23 am-12:34 pm

1 stop4h 11m

$187

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 10/21

4:37 pm-5:15 pm

Nonstop1h 38m

Lambert-St Louis

Wed 10/22

2:15 pm-4:45 pm

Nonstop1h 30m

$217

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/1

8:55 am-9:33 am

Nonstop1h 38m

Lambert-St Louis

Sat 10/4

10:40 am-1:13 pm

Nonstop1h 33m

$225

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 10/18

6:41 am-5:45 pm

1 stop12h 04m

Lambert-St Louis

Tue 10/21

10:57 am-11:29 pm

1 stop11h 32m

$226

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 10/18

7:20 am-5:45 pm

2 stops11h 25m

Lambert-St Louis

Thu 10/23

10:57 am-11:29 pm

1 stop11h 32m

$246

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Detroit to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, July is the cheapest month to fly from Detroit to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $143. The month of August is another great option to travel to St. Louis, with average flight prices from Detroit averaging around $148.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Friday when prices can be found for as low as $304. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $392. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Detroit at noon is the least expensive time of day to depart. momondo users have found prices as low as $298 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $350 per ticket.

What is the cheapest Detroit to Lambert-St Louis flight route?

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $274 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Detroit for as low as $69 on momondo.

What cabin class options are available on Detroit to Lambert-St Louis flights?

There are 4 cabin classes available to choose from on Detroit to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Detroit to St. Louis.

How have Detroit to St. Louis flight prices changed over time?

As of August 2025, prices for Detroit to St. Louis flights are approximately 52% cheaper when compared to flights at the same time last year.

When to book flights from Detroit to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to St. Louis (DTT to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to St. Louis

Best Price Found

$59

Fastest flight time

1h 32m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Detroit in the past 72 hours is $59. The best round-trip flight deal from Detroit to St. Louis found on momondo in the last 72 hours is $119.
The fastest flight from Detroit to St. Louis takes 1h 32m
Direct flights go from Detroit to St. Louis every day.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is Detroit to Lambert-St Louis by plane?

    There are 454.1 mi between Detroit and Lambert-St Louis. A reasonable flight in good conditions will take 1h 35m.

  • When did momondo last update prices for flights from Detroit to Lambert-St Louis Airport?

    Prices for flights from Detroit to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Lambert-St Louis Airport?

  • How old do you have to be to fly from Detroit to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Detroit to St. Louis?

  • What is the most popular airline from Detroit to St. Louis?

Best airlines flying from Detroit to St. Louis

Compare and see reviews for airlines that fly from Detroit to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $36Free CancellationRating
6.3
8,035 reviews
Search Spirit Airlines flights
DeltaPriceFrom $146Free CancellationRating
7.9
7,981 reviews
Search Delta flights
SouthwestPriceFrom $148Free CancellationRating
8.0
4,245 reviews
Search Southwest flights
United AirlinesPriceFrom $313Free CancellationRating
7.4
8,930 reviews
Search United Airlines flights

  • Southwest Flights From Detroit to St. Louis

    Southwest operates around 8 flights from Detroit to St. Louis every week. The average price of these flights found in the last 72 hours has been $300, but momondo users have found Southwest deals from Detroit to St. Louis from as low as $148 round-trip. Southwest has been scored 8.0/10 in 4,245 reviews.

  • Delta Flights From Detroit to St. Louis

    The best Delta deal for Detroit to St. Louis flight tickets found on momondo in the last 72 hours was $146, round-trip. It should be noted that an average Delta flight deal for this route in this time was higher, at $304 round-trip. Delta operates 14 flights out of Detroit into St. Louis in an average week, so prices vary by time and availability. 7,981 Delta reviews by users on momondo have scored the airline at 7.9/10.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Fairview Heights
Hermann
Maryland Heights
Florissant
O'Fallon
Fenton
Collinsville
Wentzville
Alton
St. Peters
Festus
Farmington
Glencoe
Clayton
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Detroit.

Can I find flights from Detroit to St. Louis with flexible booking policies on momondo?

All flight searches from Detroit to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to St. Louis?

Once you have performed a search for Detroit to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Detroit. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
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