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Cheap flights from Detroit to St. Louis from $64

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to St. Louis departing on 2/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Detroit to St. Louis

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:02 pm - 6:51 am
DTW
-
STL
13h 49m
1 stop
Multiple Airlines Logo
8:20 pm - 8:32 am
STL
-
DTW
11h 12m
1 stop
$128Multiple Airlines
Tue, Feb 17 - Fri, Feb 20
Multiple Airlines Logo
6:02 pm - 6:51 am
DTW
-
STL
13h 49m
1 stop
Multiple Airlines Logo
8:20 pm - 8:32 am
STL
-
DTW
11h 12m
1 stop
$142Multiple Airlines
Tue, Feb 17 - Fri, Feb 20
Frontier Logo
8:30 am - 3:53 pm
DTW
-
STL
8h 23m
1 stop
Frontier Logo
8:12 pm - 10:59 am
STL
-
DTW
13h 47m
1 stop
$143Frontier
Wed, Mar 4 - Mon, Mar 9
Frontier Logo
6:25 pm - 11:59 pm
DTW
-
STL
6h 34m
1 stop
Frontier Logo
8:17 pm - 8:07 am
STL
-
DTW
10h 50m
1 stop
$144Frontier
Sat, Feb 21 - Wed, Feb 25
Multiple Airlines Logo
10:00 pm - 6:51 am
DTW
-
STL
9h 51m
1 stop
Multiple Airlines Logo
8:22 pm - 3:57 pm
STL
-
DTW
18h 35m
1 stop
$145Multiple Airlines
Fri, Feb 27 - Mon, Mar 2
Multiple Airlines Logo
6:10 pm - 6:51 am
DTW
-
STL
13h 41m
2 stops
Multiple Airlines Logo
8:20 pm - 8:32 am
STL
-
DTW
11h 12m
1 stop
$151Multiple Airlines
Tue, Feb 17 - Fri, Feb 20
Multiple Airlines Logo
8:30 am - 3:53 pm
DTW
-
STL
8h 23m
1 stop
Multiple Airlines Logo
10:11 pm - 4:30 am
STL
-
DTW
29h 19m
1 stop
$168Multiple Airlines
Wed, Feb 25 - Thu, Feb 26
Multiple Airlines Logo
10:29 pm - 6:51 am
DTW
-
STL
9h 22m
1 stop
Multiple Airlines Logo
8:22 pm - 11:07 pm
STL
-
DTW
25h 45m
1 stop
$171Multiple Airlines
Fri, Feb 13 - Mon, Feb 16
Multiple Airlines Logo
7:14 pm - 6:51 am
DTW
-
STL
12h 37m
1 stop
Multiple Airlines Logo
8:22 pm - 1:30 pm
STL
-
DTW
16h 08m
1 stop
$172Multiple Airlines
Fri, Feb 6 - Mon, Feb 9
Multiple Airlines Logo
6:10 pm - 6:51 am
DTW
-
STL
13h 41m
2 stops
Multiple Airlines Logo
8:20 pm - 8:32 am
STL
-
DTW
11h 12m
1 stop
$174Multiple Airlines
Tue, Feb 17 - Fri, Feb 20

Southwest flights from Detroit to St. Louis

Our best Southwest deals on Detroit to St. Louis flight tickets
Southwest
Mar 16
DTW8:10 pmDetroit Metropolitan Wayne County
1h 45m
STL8:55 pmLambert-St Louis
Mar 18
STL11:05 amLambert-St Louis
1h 30m
DTW1:35 pmDetroit Metropolitan Wayne County
$206
Southwest
Feb 25
DTW5:50 amDetroit Metropolitan Wayne County
2h 00m
STL6:50 amLambert-St Louis
Feb 26
STL8:10 pmLambert-St Louis
1h 30m
DTW10:40 pmDetroit Metropolitan Wayne County
$215
Southwest
Feb 23
DTW6:35 pmDetroit Metropolitan Wayne County
6h 00m
1 stop
STL11:35 pmLambert-St Louis
Feb 26
STL8:10 pmLambert-St Louis
1h 30m
DTW10:40 pmDetroit Metropolitan Wayne County
$225

Frontier flights from Detroit to St. Louis

Our best Frontier deals on Detroit to St. Louis flight tickets
Frontier
Mar 4
DTW8:30 amDetroit Metropolitan Wayne County
8h 23m
1 stop
STL3:53 pmLambert-St Louis
Mar 9
STL8:12 pmLambert-St Louis
13h 47m
1 stop
DTW10:59 amDetroit Metropolitan Wayne County
$143
Frontier
Feb 21
DTW3:17 pmDetroit Metropolitan Wayne County
9h 42m
1 stop
STL11:59 pmLambert-St Louis
Feb 25
STL8:17 pmLambert-St Louis
10h 50m
1 stop
DTW8:07 amDetroit Metropolitan Wayne County
$144
Frontier
Mar 5
DTW6:00 amDetroit Metropolitan Wayne County
28h 49m
1 stop
STL9:49 amLambert-St Louis
Mar 9
STL8:12 pmLambert-St Louis
13h 47m
1 stop
DTW10:59 amDetroit Metropolitan Wayne County
$179

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated January 24, 2026.
Use the filters below to find and compare flights from Detroit to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 2/17

6:02 pm-6:51 am

1 stop13h 49m

Lambert-St Louis

Fri 2/20

8:20 pm-8:32 am

1 stop11h 12m

$128

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 2/17

6:02 pm-6:51 am

1 stop13h 49m

Lambert-St Louis

Fri 2/20

8:20 pm-8:32 am

1 stop11h 12m

$142

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 3/4

8:30 am-3:53 pm

1 stop8h 23m

Lambert-St Louis

Mon 3/9

8:12 pm-10:59 am

1 stop13h 47m

$143

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sat 2/21

6:25 pm-11:59 pm

1 stop6h 34m

Lambert-St Louis

Wed 2/25

8:17 pm-8:07 am

1 stop10h 50m

$144

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 2/27

10:00 pm-6:51 am

1 stop9h 51m

Lambert-St Louis

Mon 3/2

8:22 pm-3:57 pm

1 stop18h 35m

$145

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 2/17

6:10 pm-6:51 am

2 stops13h 41m

Lambert-St Louis

Fri 2/20

8:20 pm-8:32 am

1 stop11h 12m

$151

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 2/25

8:30 am-3:53 pm

1 stop8h 23m

Lambert-St Louis

Thu 2/26

10:11 pm-4:30 am

1 stop29h 19m

$168

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 2/13

10:29 pm-6:51 am

1 stop9h 22m

Lambert-St Louis

Mon 2/16

8:22 pm-11:07 pm

1 stop25h 45m

$171

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 2/6

7:14 pm-6:51 am

1 stop12h 37m

Lambert-St Louis

Mon 2/9

8:22 pm-1:30 pm

1 stop16h 08m

$172

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Tue 2/17

6:10 pm-6:51 am

2 stops13h 41m

Lambert-St Louis

Fri 2/20

8:20 pm-8:32 am

1 stop11h 12m

$174

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Detroit to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Detroit to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $121. The month of July is another great option to travel to St. Louis, with average flight prices from Detroit averaging around $143.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $296. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $383. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Detroit at noon is the least expensive time of day to depart. momondo users have found prices as low as $298 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $330 per ticket.

What is the cheapest Detroit to Lambert-St Louis flight route?

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $273 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Detroit for as low as $69 on momondo.

What cabin class options are available on Detroit to Lambert-St Louis flights?

There are 4 cabin classes available to choose from on Detroit to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Detroit to St. Louis.

How have Detroit to St. Louis flight prices changed over time?

As of January 2026, prices for Detroit to St. Louis flights are approximately 16% cheaper when compared to flights at the same time last year.

When to book flights from Detroit to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to St. Louis (DTT to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to St. Louis

Best Price Found

$196

Fastest flight time

1h 35m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Detroit in the past 72 hours is $196. The best round-trip flight deal from Detroit to St. Louis found on momondo in the last 72 hours is $327.
The fastest flight from Detroit to St. Louis takes 1h 35m
Direct flights go from Detroit to St. Louis every day.
There is 1 airport in St. Louis. From Detroit there are direct flights to Lambert-St Louis (STL).
Search flight deals

  • How far is Detroit to Lambert-St Louis by plane?

    There are 454.1 mi between Detroit and Lambert-St Louis. A reasonable flight in good conditions will take 1h 35m.

  • When did momondo last update prices for flights from Detroit to Lambert-St Louis Airport?

    Prices for flights from Detroit to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Lambert-St Louis Airport?

  • How old do you have to be to fly from Detroit to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Detroit to St. Louis?

  • What is the most popular airline from Detroit to St. Louis?

Best airlines flying from Detroit to St. Louis

Compare and see reviews for airlines that fly from Detroit to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $28Free CancellationRating
6.3
8,370 reviews
Search Spirit Airlines flights
FrontierPriceFrom $111Free CancellationRating
5.7
3,058 reviews
Search Frontier flights
DeltaPriceFrom $128Free CancellationRating
7.9
8,110 reviews
Search Delta flights
SouthwestPriceFrom $137Free CancellationRating
8.0
4,268 reviews
Search Southwest flights

  • Southwest Flights From Detroit to St. Louis

    Southwest operates around 5 flights from Detroit to St. Louis every week. The average price of these flights found in the last 72 hours has been $290, but momondo users have found Southwest deals from Detroit to St. Louis from as low as $137 round-trip. Southwest has been scored 8.0/10 in 4,268 reviews.

  • Delta Flights From Detroit to St. Louis

    The best Delta deal for Detroit to St. Louis flight tickets found on momondo in the last 72 hours was $128, round-trip. It should be noted that an average Delta flight deal for this route in this time was higher, at $307 round-trip. Delta operates 20 flights out of Detroit into St. Louis in an average week, so prices vary by time and availability. 8,110 Delta reviews by users on momondo have scored the airline at 7.9/10.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Maryland Heights
Florissant
O'Fallon
Fenton
Collinsville
St. Peters
Wentzville
Alton
Farmington
Clayton
Eureka
Edwardsville
Festus
Glencoe
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Detroit.

Can I find flights from Detroit to St. Louis with flexible booking policies on momondo?

All flight searches from Detroit to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to St. Louis?

Once you have performed a search for Detroit to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Detroit. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
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