Cheap flights from Detroit to St. Louis from $65

In general, June is the cheapest month to fly from Detroit to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $26. The month of September is another great option to travel to St. Louis, with average flight prices from Detroit averaging around $27.

The cheapest day to depart on your flight to St. Louis is on a Thursday when prices can be found for as low as $312. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $402. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

Flying to St. Louis from Detroit at noon is the least expensive time of day to depart. momondo users have found prices as low as $270 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $364 per ticket.

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit - Lambert-St Louis flight prices

You are more likely to see cheaper flights to St. Louis from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $302 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Detroit for as low as $69 on momondo.

You could potentially save up to 11% on your flight if you consider stops on a Detroit to St. Louis flight.

As of April 2026, prices for Detroit to St. Louis flights are approximately 21% cheaper when compared to flights at the same time last year.

Frontier is the most popular carrier operating from Detroit to Lambert-St Louis

Delta, Southwest and Spirit Airlines are the top three most popular airlines that fly to St. Louis from Detroit according to our data. Delta is the first choice among our users, with 56% of people opting to fly with this airline when traveling to St. Louis. Keep in mind that there are 4 different airlines that fly to St. Louis on a routine basis, so you have a few additional options to choose from.

As of April 2026, there are 15 flights per day flying from Detroit to St. Louis. The most common time of day flights depart is 4:00PM, with 48% of flights taking off in the afternoon.

106 flights are operational weekly from Detroit to St. Louis as of April 2026. The most popular departure day for this route is Mon, with 16% of flights per week taking off on this day.