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Cheap flights from Detroit to St. Louis from $71

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit to St. Louis departing on 11/12. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit to St. Louis

Cheap round-trip flights

Logo
7:20 am - 3:04 pmDTW-STL
8h 44m1 stop
Logo
4:00 pm - 2:46 pmSTL-DTW
21h 46m1 stop
$164
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Sun, Sep 28 - Thu, Oct 2
Frontier Logo
1:36 pm - 8:37 pmDTW-STL
8h 01m1 stop
Frontier Logo
1:57 pm - 8:44 amSTL-DTW
17h 47m1 stop
$171Frontier
Find Deal
Fri, Oct 3 - Sun, Oct 5
Frontier Logo
1:36 pm - 8:37 pmDTW-STL
8h 01m1 stop
Frontier Logo
1:57 pm - 8:44 amSTL-DTW
17h 47m1 stop
$174Frontier
Find Deal
Fri, Oct 3 - Sun, Oct 5
Frontier Logo
6:10 am - 9:06 amDTW-STL
27h 56m1 stop
Frontier Logo
1:57 pm - 8:44 amSTL-DTW
17h 47m1 stop
$180Frontier
Find Deal
Thu, Oct 2 - Sun, Oct 5
American Airlines Logo
7:00 am - 1:44 pmDTW-STL
7h 44m1 stop
American Airlines Logo
6:00 am - 5:34 pmSTL-DTW
10h 34m1 stop
$183American Airlines
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Wed, Oct 8 - Wed, Oct 15
American Airlines Logo
5:30 am - 8:09 amDTW-STL
3h 39m1 stop
American Airlines Logo
9:58 am - 5:34 pmSTL-DTW
6h 36m1 stop
$223American Airlines
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Thu, Oct 16 - Wed, Oct 29
Southwest Logo
8:05 pm - 8:45 pmDTW-STL
1h 40mnonstop
Southwest Logo
8:10 pm - 10:40 pmSTL-DTW
1h 30mnonstop
$237Southwest
Find Deal
Fri, Oct 3 - Mon, Oct 6
Southwest Logo
6:45 am - 8:50 amDTW-STL
3h 05m1 stop
Southwest Logo
6:10 pm - 8:40 pmSTL-DTW
1h 30mnonstop
$243Southwest
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Thu, Oct 30 - Mon, Nov 3
Delta Logo
7:45 pm - 8:23 pmDTW-STL
1h 38mnonstop
Delta Logo
10:45 am - 1:17 pmSTL-DTW
1h 32mnonstop
$255Delta
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Thu, Oct 16 - Wed, Oct 29
Delta Logo
7:45 pm - 8:23 pmDTW-STL
1h 38mnonstop
Delta Logo
6:00 am - 11:43 amSTL-DTW
4h 43m1 stop
$265Delta
Find Deal
Thu, Oct 16 - Wed, Oct 29

Frontier flights from Detroit to St. Louis

Our best Frontier deals on Detroit to St. Louis flight tickets
Frontier
Oct 3
DTW1:36 pmDetroit Metropolitan Wayne County
8h 01m
1 stop
STL8:37 pmLambert-St Louis
Oct 5
STL1:57 pmLambert-St Louis
17h 47m
1 stop
DTW8:44 amDetroit Metropolitan Wayne County
$171
Find similar
Frontier
Oct 3
DTW1:36 pmDetroit Metropolitan Wayne County
8h 01m
1 stop
STL8:37 pmLambert-St Louis
Oct 5
STL1:57 pmLambert-St Louis
17h 47m
1 stop
DTW8:44 amDetroit Metropolitan Wayne County
$174
Find similar
Frontier
Oct 2
DTW6:10 amDetroit Metropolitan Wayne County
27h 56m
1 stop
STL9:06 amLambert-St Louis
Oct 5
STL1:57 pmLambert-St Louis
17h 47m
1 stop
DTW8:44 amDetroit Metropolitan Wayne County
$180
Find similar

American Airlines flights from Detroit to St. Louis

Our best American Airlines deals on Detroit to St. Louis flight tickets
American Airlines
Oct 8
DTW7:00 amDetroit Metropolitan Wayne County
7h 44m
1 stop
STL1:44 pmLambert-St Louis
Oct 15
STL6:00 amLambert-St Louis
10h 34m
1 stop
DTW5:34 pmDetroit Metropolitan Wayne County
$183
Find similar
American Airlines
Oct 16
DTW5:30 amDetroit Metropolitan Wayne County
3h 39m
1 stop
STL8:09 amLambert-St Louis
Oct 29
STL9:58 amLambert-St Louis
6h 36m
1 stop
DTW5:34 pmDetroit Metropolitan Wayne County
$223
Find similar
American Airlines
Oct 2
DTW7:18 pmDetroit Metropolitan Wayne County
5h 31m
1 stop
STL11:49 pmLambert-St Louis
Oct 5
STL5:27 amLambert-St Louis
4h 40m
1 stop
DTW11:07 amDetroit Metropolitan Wayne County
$228
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Detroit to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Sun 9/28

7:20 am-3:04 pm

1 stop8h 44m

Lambert-St Louis

Thu 10/2

4:00 pm-2:46 pm

1 stop21h 46m

$164

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 10/3

1:36 pm-8:37 pm

1 stop8h 01m

Lambert-St Louis

Sun 10/5

1:57 pm-8:44 am

1 stop17h 47m

$171

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 10/3

1:36 pm-8:37 pm

1 stop8h 01m

Lambert-St Louis

Sun 10/5

1:57 pm-8:44 am

1 stop17h 47m

$174

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/2

6:10 am-9:06 am

1 stop27h 56m

Lambert-St Louis

Sun 10/5

1:57 pm-8:44 am

1 stop17h 47m

$180

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Wed 10/8

7:00 am-1:44 pm

1 stop7h 44m

Lambert-St Louis

Wed 10/15

6:00 am-5:34 pm

1 stop10h 34m

$183

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/16

5:30 am-8:09 am

1 stop3h 39m

Lambert-St Louis

Wed 10/29

9:58 am-5:34 pm

1 stop6h 36m

$223

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Fri 10/3

8:05 pm-8:45 pm

Nonstop1h 40m

Lambert-St Louis

Mon 10/6

8:10 pm-10:40 pm

Nonstop1h 30m

$237

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/30

6:45 am-8:50 am

1 stop3h 05m

Lambert-St Louis

Mon 11/3

6:10 pm-8:40 pm

Nonstop1h 30m

$243

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/16

7:45 pm-8:23 pm

Nonstop1h 38m

Lambert-St Louis

Wed 10/29

10:45 am-1:17 pm

Nonstop1h 32m

$255

DetroitSt. Louis

DTW - STL

DTWSTL

Detroit Metropolitan Wayne County

Thu 10/16

7:45 pm-8:23 pm

Nonstop1h 38m

Lambert-St Louis

Wed 10/29

6:00 am-11:43 am

1 stop4h 43m

$265

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to St. Louis from

How to get the cheapest flight ticket from Detroit to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit and St. Louis?

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Detroit to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $121. The month of July is another great option to travel to St. Louis, with average flight prices from Detroit averaging around $143.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Friday when prices can be found for as low as $304. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $387. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Detroit at noon is the least expensive time of day to depart. momondo users have found prices as low as $279 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $346 per ticket.

What is the cheapest Detroit to Lambert-St Louis flight route?

Fly from Detroit Metropolitan Wayne County to Lambert-St Louis for the best Detroit - Lambert-St Louis flight prices

How far in advance should I book a flight to St. Louis?

You are more likely to see cheaper flights to St. Louis from Detroit when booking weeks ahead of your departure date. In general, you can expect to find flights to St. Louis for around $271 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to St. Louis from Detroit for as low as $69 on momondo.

What cabin class options are available on Detroit to Lambert-St Louis flights?

There are 4 cabin classes available to choose from on Detroit to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit to St. Louis flights?

No. A direct flight is the cheapest option for a flight between Detroit to St. Louis.

How have Detroit to St. Louis flight prices changed over time?

As of September 2025, prices for Detroit to St. Louis flights are approximately 18% cheaper when compared to flights at the same time last year.

When to book flights from Detroit to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit to St. Louis (DTT to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit to St. Louis

Best Price Found

$135

Fastest flight time

1h 35m

Direct flights

Every day

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Detroit in the past 72 hours is $135. The best round-trip flight deal from Detroit to St. Louis found on momondo in the last 72 hours is $257.
The fastest flight from Detroit to St. Louis takes 1h 35m
Direct flights go from Detroit to St. Louis every day.
There is 1 airport near St. Louis: Lambert-St Louis (STL)
Search flight deals

  • How far is Detroit to Lambert-St Louis by plane?

    There are 454.1 mi between Detroit and Lambert-St Louis. A reasonable flight in good conditions will take 1h 37m.

  • When did momondo last update prices for flights from Detroit to Lambert-St Louis Airport?

    Prices for flights from Detroit to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Detroit to Lambert-St Louis Airport?

  • How old do you have to be to fly from Detroit to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines offering an unaccompanied minor (UNMR) service may have their age restrictions, such as regulations concerning flight duration, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Detroit to St. Louis?

  • What is the most popular airline from Detroit to St. Louis?

Best airlines flying from Detroit to St. Louis

Compare and see reviews for airlines that fly from Detroit to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $36Free CancellationRating
6.3
8,015 reviews
Search Spirit Airlines flights
DeltaPriceFrom $141Free CancellationRating
7.9
7,954 reviews
Search Delta flights
SouthwestPriceFrom $148Free CancellationRating
8.0
4,242 reviews
Search Southwest flights
United AirlinesPriceFrom $313Free CancellationRating
7.4
8,929 reviews
Search United Airlines flights

  • Southwest Flights From Detroit to St. Louis

    Southwest operates around 10 flights from Detroit to St. Louis every week. The average price of these flights found in the last 72 hours has been $300, but momondo users have found Southwest deals from Detroit to St. Louis from as low as $148 round-trip. Southwest has been scored 8.0/10 in 4,242 reviews.

  • Delta Flights From Detroit to St. Louis

    The best Delta deal for Detroit to St. Louis flight tickets found on momondo in the last 72 hours was $141, round-trip. It should be noted that an average Delta flight deal for this route in this time was higher, at $303 round-trip. Delta operates 22 flights out of Detroit into St. Louis in an average week, so prices vary by time and availability. 7,954 Delta reviews by users on momondo have scored the airline at 7.9/10.

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
St. Charles
Chesterfield
Hermann
Fairview Heights
Florissant
Maryland Heights
O'Fallon
Fenton
Collinsville
Wentzville
Alton
St. Peters
Farmington
Festus
Glencoe
Clayton
Edwardsville
Eureka
Litchfield
Shrewsbury

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to St. Louis?

To find the flight that best suits your needs, momondo gathers a range of flights from a large pool of different airlines and agents; you can then use our insights and filters to find and book the right flight to St. Louis from Detroit.

Can I find flights from Detroit to St. Louis with flexible booking policies on momondo?

All flight searches from Detroit to St. Louis on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to St. Louis?

Once you have performed a search for Detroit to St. Louis flights, momondo helps you find the right one by offering useful filters to narrow down your flight selection. Flights can be filtered by multiple factors such as airline, airport and price; but also by other criteria like aircraft type and payment method.

I’m not ready to book a flight from Detroit to St. Louis right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to St. Louis from Detroit. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.

An easier way to manage your St. Louis trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
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