What airlines fly to South Carolina?

Delta, Spirit Airlines and American Airlines are the top three most popular airlines that fly to South Carolina from Detroit Metropolitan Wayne County Airport according to our data. Delta is the first choice among our users, with 49% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Detroit Metropolitan Wayne County to South Carolina?

Frontier, Spirit Airlines, and Delta are the most popular carriers operating from Detroit Metropolitan Wayne County to South Carolina

How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$54 Cheap Flights from Detroit Metropolitan Wayne County Airport to South Carolina in 2026

Q: How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per day?

As of February 2026, 30 flights take off from Detroit Metropolitan Wayne County Airport and land in South Carolina each day. The most common flight departure time for this route is 8:00PM, with 53% of daily flights taking off in the afternoon.

Q: How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per week?

As of February 2026, there are 213 flights per week flying from Detroit Metropolitan Wayne County Airport to South Carolina. The most common day of the week flights depart is Fri, with 18% of flights taking off on this day.

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina

Round-trip

One-way

Last minute

Direct

Cheap round-trip flights

Enter your travel dates to find the best prices.

5:09 am - 4:05 pm

DTW

CHS

10h 56m

1 stop

5:00 pm - 7:49 am

CHS

DTW

14h 49m

1 stop

$113Spirit Airlines

Wed, Mar 4 - Mon, Mar 9

5:09 am - 4:05 pm

DTW

CHS

10h 56m

1 stop

5:00 pm - 12:09 am

CHS

DTW

7h 09m

1 stop

$116Spirit Airlines

Tue, Mar 3 - Tue, Mar 10

10:59 pm - 4:05 pm

DTW

CHS

17h 06m

1 stop

5:00 pm - 12:09 am

CHS

DTW

7h 09m

1 stop

$124Spirit Airlines

Sun, Mar 8 - Tue, Mar 10

12:06 pm - 8:12 pm

DTW

CLT

8h 06m

1 stop

4:45 pm - 6:43 pm

CLT

DTW

1h 58mnonstop

$141Multiple Airlines

Sat, Feb 21 - Mon, Feb 23

10:41 am - 12:32 pm

DTW

CLT

1h 51mnonstop

3:12 pm - 9:54 pm

CLT

DTW

6h 42m

1 stop

$143Multiple Airlines

Fri, Feb 27 - Tue, Mar 3

2:03 pm - 9:24 pm

DTW

CAE

7h 21m

1 stop

5:34 am - 9:27 am

CAE

DTW

3h 53m

1 stop

$269Delta

Wed, Mar 11 - Sat, Mar 14

8:50 am - 2:21 pm

DTW

CAE

5h 31m

1 stop

5:35 am - 9:30 am

CAE

DTW

3h 55m

1 stop

$274Delta

Wed, Feb 25 - Sat, Feb 28

6:00 am - 1:40 pm

DTW

HHH

7h 40m

1 stop

6:50 pm - 12:25 am

HHH

DTW

5h 35m

1 stop

$283American Airlines

Sat, Apr 25 - Sat, May 2

6:00 am - 1:40 pm

DTW

HHH

7h 40m

1 stop

2:54 pm - 12:44 am

HHH

DTW

9h 50m

2 stops

$288American Airlines

Sat, Apr 18 - Sat, Apr 25

9:00 am - 2:06 pm

DTW

HHH

5h 06m

1 stop

3:00 pm - 10:12 pm

HHH

DTW

7h 12m

1 stop

$339United Airlines

Sun, Apr 12 - Thu, Apr 23

Frontier flights from Detroit Metropolitan Wayne County Airport to South Carolina

Our best Frontier deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets

Frontier

Feb 16

DTW10:31 amDetroit Metropolitan Wayne County

1h 51m

CLT12:22 pmCharlotte Douglas

Feb 23

CLT4:45 pmCharlotte Douglas

1h 58m

DTW6:43 pmDetroit Metropolitan Wayne County

$142

Frontier

Feb 16

DTW10:31 amDetroit Metropolitan Wayne County

1h 51m

CLT12:22 pmCharlotte Douglas

Feb 16

CLT4:45 pmCharlotte Douglas

1h 58m

DTW6:43 pmDetroit Metropolitan Wayne County

$148

Frontier

Feb 23

DTW10:41 amDetroit Metropolitan Wayne County

1h 51m

CLT12:32 pmCharlotte Douglas

Feb 26

CLT10:24 pmCharlotte Douglas

11h 18m

1 stop

DTW9:42 amDetroit Metropolitan Wayne County

$153

Spirit Airlines flights from Detroit Metropolitan Wayne County Airport to South Carolina

Our best Spirit Airlines deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets

Spirit Airlines

Mar 4

DTW5:09 amDetroit Metropolitan Wayne County

10h 56m

1 stop

CHS4:05 pmCharleston

Mar 9

CHS5:00 pmCharleston

14h 49m

1 stop

DTW7:49 amDetroit Metropolitan Wayne County

$113

Spirit Airlines

Mar 3

DTW5:09 amDetroit Metropolitan Wayne County

10h 56m

1 stop

CHS4:05 pmCharleston

Mar 10

CHS5:00 pmCharleston

7h 09m

1 stop

DTW12:09 amDetroit Metropolitan Wayne County

$116

Spirit Airlines

Mar 8

DTW10:59 pmDetroit Metropolitan Wayne County

17h 06m

1 stop

CHS4:05 pmCharleston

Mar 10

CHS5:00 pmCharleston

7h 09m

1 stop

DTW12:09 amDetroit Metropolitan Wayne County

$124

momondo Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Wed 3/4

5:09 am-4:05 pm

1 stop10h 56m

Charleston

Mon 3/9

5:00 pm-7:49 am

1 stop14h 49m

$113

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Tue 3/3

5:09 am-4:05 pm

1 stop10h 56m

Charleston

Tue 3/10

5:00 pm-12:09 am

1 stop7h 09m

$116

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Sun 3/8

10:59 pm-4:05 pm

1 stop17h 06m

Charleston

Tue 3/10

5:00 pm-12:09 am

1 stop7h 09m

$124

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Sat 2/21

12:06 pm-8:12 pm

1 stop8h 06m

Charlotte Douglas

Mon 2/23

4:45 pm-6:43 pm

Nonstop1h 58m

$141

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Fri 2/27

10:41 am-12:32 pm

Nonstop1h 51m

Charlotte Douglas

Tue 3/3

3:12 pm-9:54 pm

1 stop6h 42m

$143

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Wed 3/11

2:03 pm-9:24 pm

1 stop7h 21m

Columbia Metropolitan

Sat 3/14

5:34 am-9:27 am

1 stop3h 53m

$269

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Wed 2/25

8:50 am-2:21 pm

1 stop5h 31m

Columbia Metropolitan

Sat 2/28

5:35 am-9:30 am

1 stop3h 55m

$274

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Sat 4/25

6:00 am-1:40 pm

1 stop7h 40m

Hilton Head Island

Sat 5/2

6:50 pm-12:25 am

1 stop5h 35m

$283

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Sat 4/18

6:00 am-1:40 pm

1 stop7h 40m

Hilton Head Island

Sat 4/25

2:54 pm-12:44 am

2 stops9h 50m

$288

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Sun 4/12

9:00 am-2:06 pm

1 stop5h 06m

Hilton Head Island

Thu 4/23

3:00 pm-10:12 pm

1 stop7h 12m

$339

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Detroit Metropolitan Wayne County Airport is in August. Flight prices, which tend to average around $224, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Detroit Metropolitan Wayne County Airport during July instead. Flights to South Carolina in July, while not as cheap as those in August, still average around $248.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $299. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $339.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Detroit Metropolitan Wayne County Airport to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $299. Try not to purchase tickets in the afternoon because they tend to be around $367. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Detroit Metropolitan Wayne County to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Charleston for the best Detroit Metropolitan Wayne County - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $327 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit Metropolitan Wayne County Airport for as low as $216 on momondo.

What cabin class options are available on Detroit Metropolitan Wayne County to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Detroit Metropolitan Wayne County Airport to South Carolina.

Cheap Detroit Metropolitan Wayne County Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to South Carolina

Best Price Found	$208
Fastest flight time	1h 39m
Direct flights	Every day
Airports in South Carolina	57 airports

The best one-way flight to South Carolina from Detroit Metropolitan Wayne County Airport in the past 72 hours is $208. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to South Carolina found on momondo in the last 72 hours is $327.

The fastest flight from Detroit Metropolitan Wayne County Airport to South Carolina takes 1h 39m

Direct flights go from Detroit Metropolitan Wayne County Airport to South Carolina every day.

There are 57 airports in South Carolina. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP), Myrtle Beach Intl (MYR), Charlotte Douglas (CLT), Augusta Bush Field (AGS).

Search flight deals

When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina?
Prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to South Carolina?
The number of operators available for flights from Detroit Metropolitan Wayne County Airport to South Carolina is 6 as of February 2026.
How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Detroit Metropolitan Wayne County Airport to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Detroit Metropolitan Wayne County Airport to South Carolina is Canadair (Bombardier) Regional Jet 900, representing 30.17% of all bookings. The subsequent popular models are Boeing 717-200 at 21.41%, Airbus A320-100/200 at 18.98%, and Airbus A319 at 7.30%.

Best airlines flying from Detroit Metropolitan Wayne County Airport to South Carolina

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $64	Free Cancellation	Rating 6.3 8,421 reviews	Search Spirit Airlines flights
Delta	PriceFrom $158	Free Cancellation	Rating 7.9 8,162 reviews	Search Delta flights
American Airlines	PriceFrom $198	Free Cancellation	Rating 7.2 11,248 reviews	Search American Airlines flights
Southwest	PriceFrom $207	Free Cancellation	Rating 8.0 4,280 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

Flights from Detroit to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Detroit to South Carolina.

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Flights to New Yorkfrom $49

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Flights to Miamifrom $27

Flights to Chicagofrom $50

Flights to Orlandofrom $27

Flights to San Franciscofrom $68

Flights to Las Vegasfrom $48

Flights to Washington, D.C.from $56

Flights to Bostonfrom $50

Flights to Atlantafrom $49

Flights to Dallasfrom $50

Flights to Seattlefrom $65

Cheap flights from Detroit Metropolitan Wayne County Airport to South Carolina from $54

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina

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Frontier flights from Detroit Metropolitan Wayne County Airport to South Carolina

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Our best Spirit Airlines deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets

momondo Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

See travel insights to South Carolina from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to South Carolina

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $299. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $339.

What is the cheapest time of day to depart on your flight to South Carolina?

What is the cheapest Detroit Metropolitan Wayne County to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Charleston for the best Detroit Metropolitan Wayne County - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

What cabin class options are available on Detroit Metropolitan Wayne County to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Detroit Metropolitan Wayne County Airport to South Carolina.

What is the cheapest airline that flies from Detroit Metropolitan Wayne County to South Carolina?

Frontier, Spirit Airlines, and Delta are the most popular carriers operating from Detroit Metropolitan Wayne County to South Carolina

What airlines fly to South Carolina?

How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per day?

As of February 2026, 30 flights take off from Detroit Metropolitan Wayne County Airport and land in South Carolina each day. The most common flight departure time for this route is 8:00PM, with 53% of daily flights taking off in the afternoon.

How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per week?

As of February 2026, there are 213 flights per week flying from Detroit Metropolitan Wayne County Airport to South Carolina. The most common day of the week flights depart is Fri, with 18% of flights taking off on this day.

Cheap Detroit Metropolitan Wayne County Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina?

How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to South Carolina?

How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

What documentation or ID do you need to fly to South Carolina?

What is the most popular plane model from Detroit Metropolitan Wayne County Airport to South Carolina?

Best airlines flying from Detroit Metropolitan Wayne County Airport to South Carolina

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Detroit to South Carolina?

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo

Detroit Metropolitan Wayne County Airport flight routes

According to popular flight searches on momondo this year

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According to popular flight searches on momondo this year

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