What is the cheapest airline that flies from Detroit Metropolitan Wayne County to South Carolina?

Frontier and Spirit Airlines are the most popular carriers operating from Detroit Metropolitan Wayne County to South Carolina

What airlines fly to South Carolina?

Delta, Spirit Airlines and American Airlines are the top three most popular airlines that fly to South Carolina from Detroit Metropolitan Wayne County Airport according to our data. Delta is the first choice among our users, with 48% of people opting to fly with this airline when traveling to South Carolina. Keep in mind that there are 4 different airlines that fly to South Carolina on a routine basis, so you have a few additional options to choose from.

How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to South Carolina.

What documentation or ID do you need to fly to South Carolina?

The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

$39 Cheap Flights from Detroit Metropolitan Wayne County Airport to South Carolina in 2025/26

Q: How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per day?

As of November 2025, 29 flights take off from Detroit Metropolitan Wayne County Airport and land in South Carolina each day. The most common flight departure time for this route is 4:00PM, with 57% of daily flights taking off in the afternoon.

Q: How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per week?

As of November 2025, there are 208 flights per week flying from Detroit Metropolitan Wayne County Airport to South Carolina. The most common day of the week flights depart is Mon, with 20% of flights taking off on this day.

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina

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One-way

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Cheap round-trip flights

Enter your travel dates to find the best prices.

10:42 am - 5:06 pmDTW-CHS

6h 24m1 stop

6:13 pm - 11:59 pmCHS-DTW

5h 46m1 stop

$100Spirit Airlines

Find Deal

Wed, Nov 19 - Thu, Nov 20

10:42 am - 5:06 pmDTW-CHS

6h 24m1 stop

6:13 pm - 11:59 pmCHS-DTW

5h 46m1 stop

$107Spirit Airlines

Find Deal

Mon, Nov 17 - Thu, Nov 20

6:30 am - 8:34 amDTW-CHS

2h 04mnonstop

9:29 am - 11:34 amCHS-DTW

2h 05mnonstop

$109Spirit Airlines

Find Deal

Thu, Jan 29 - Sun, Feb 1

10:48 am - 9:05 amDTW-SAV

22h 17m1 stop

7:00 am - 9:44 pmSAV-DTW

14h 44m1 stop

$153Multiple Airlines

Find Deal

Thu, Nov 20 - Sun, Nov 23

5:10 am - 11:03 amDTW-CLT

5h 53m1 stop

8:52 am - 5:12 pmCLT-DTW

8h 20m1 stop

$153Multiple Airlines

Find Deal

Wed, Jan 7 - Thu, Jan 8

10:09 am - 12:12 pmDTW-CLT

2h 03mnonstop

5:00 pm - 6:53 pmCLT-DTW

1h 53mnonstop

$169Delta

Find Deal

Wed, Jan 28 - Sun, Feb 1

6:15 am - 10:52 amDTW-CLT

4h 37m1 stop

9:30 am - 11:26 amCLT-DTW

1h 56mnonstop

$179Delta

Find Deal

Wed, Jan 28 - Sun, Feb 1

11:14 am - 1:13 pmDTW-CLT

1h 59mnonstop

9:12 am - 11:10 amCLT-DTW

1h 58mnonstop

$189American Airlines

Find Deal

Wed, Feb 18 - Sun, Feb 22

8:51 am - 1:53 pmDTW-CLT

5h 02m1 stop

10:33 pm - 8:20 amCLT-DTW

9h 47m1 stop

$190Frontier

Find Deal

Mon, Nov 24 - Thu, Dec 4

10:27 am - 3:44 pmDTW-HHH

5h 17m1 stop

4:14 pm - 10:20 pmHHH-DTW

6h 06m1 stop

$283American Airlines

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Sat, Feb 28 - Wed, Mar 4

Delta flights from Detroit Metropolitan Wayne County Airport to South Carolina

Our best Delta deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets

Delta

Jan 28

DTW10:09 amDetroit Metropolitan Wayne County

2h 03m

CLT12:12 pmCharlotte Douglas

Feb 1

CLT5:00 pmCharlotte Douglas

1h 53m

DTW6:53 pmDetroit Metropolitan Wayne County

$169

Find similar

Delta

Jan 28

DTW6:15 amDetroit Metropolitan Wayne County

4h 37m

1 stop

CLT10:52 amCharlotte Douglas

Feb 1

CLT9:30 amCharlotte Douglas

1h 56m

DTW11:26 amDetroit Metropolitan Wayne County

$179

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Delta

Nov 24

DTW8:00 pmDetroit Metropolitan Wayne County

1h 51m

CLT9:51 pmCharlotte Douglas

Dec 3

CLT12:44 pmCharlotte Douglas

1h 50m

DTW2:34 pmDetroit Metropolitan Wayne County

$191

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American Airlines flights from Detroit Metropolitan Wayne County Airport to South Carolina

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets

American Airlines

Feb 18

DTW11:14 amDetroit Metropolitan Wayne County

1h 59m

CLT1:13 pmCharlotte Douglas

Feb 22

CLT9:12 amCharlotte Douglas

1h 58m

DTW11:10 amDetroit Metropolitan Wayne County

$189

Find similar

American Airlines

Feb 28

DTW10:27 amDetroit Metropolitan Wayne County

5h 17m

1 stop

HHH3:44 pmHilton Head Island

Mar 4

HHH4:14 pmHilton Head Island

6h 06m

1 stop

DTW10:20 pmDetroit Metropolitan Wayne County

$283

Find similar

American Airlines

Feb 28

DTW10:27 amDetroit Metropolitan Wayne County

5h 17m

1 stop

HHH3:44 pmHilton Head Island

Mar 4

HHH3:39 pmHilton Head Island

7h 06m

2 stops

DTW10:45 pmDetroit Metropolitan Wayne County

$296

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momondo Fare Finder

Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Wed 11/19

10:42 am-5:06 pm

1 stop6h 24m

Charleston

Thu 11/20

6:13 pm-11:59 pm

1 stop5h 46m

$100

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Mon 11/17

10:42 am-5:06 pm

1 stop6h 24m

Charleston

Thu 11/20

6:13 pm-11:59 pm

1 stop5h 46m

$107

DetroitCharleston

DTW - CHS

DTWCHS

Detroit Metropolitan Wayne County

Thu 1/29

6:30 am-8:34 am

Nonstop2h 04m

Charleston

Sun 2/1

9:29 am-11:34 am

Nonstop2h 05m

$109

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Thu 11/20

10:48 am-9:05 am

1 stop22h 17m

Savannah/Hilton Head

Sun 11/23

7:00 am-9:44 pm

1 stop14h 44m

$153

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 1/7

5:10 am-11:03 am

1 stop5h 53m

Charlotte Douglas

Thu 1/8

8:52 am-5:12 pm

1 stop8h 20m

$153

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 1/28

10:09 am-12:12 pm

Nonstop2h 03m

Charlotte Douglas

Sun 2/1

5:00 pm-6:53 pm

Nonstop1h 53m

$169

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 1/28

6:15 am-10:52 am

1 stop4h 37m

Charlotte Douglas

Sun 2/1

9:30 am-11:26 am

Nonstop1h 56m

$179

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Wed 2/18

11:14 am-1:13 pm

Nonstop1h 59m

Charlotte Douglas

Sun 2/22

9:12 am-11:10 am

Nonstop1h 58m

$189

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Mon 11/24

8:51 am-1:53 pm

1 stop5h 02m

Charlotte Douglas

Thu 12/4

10:33 pm-8:20 am

1 stop9h 47m

$190

DetroitHilton Head Island

DTW - HHH

DTWHHH

Detroit Metropolitan Wayne County

Sat 2/28

10:27 am-3:44 pm

1 stop5h 17m

Hilton Head Island

Wed 3/4

4:14 pm-10:20 pm

1 stop6h 06m

$283

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How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

Other information

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Detroit Metropolitan Wayne County Airport is in August. Flight prices, which tend to average around $224, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Detroit Metropolitan Wayne County Airport during July instead. Flights to South Carolina in July, while not as cheap as those in August, still average around $248.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $301. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $483.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Detroit Metropolitan Wayne County Airport to South Carolina flights are usually those with departure times in the morning. Our users have found flights to South Carolina in the morning for as low as $310. Try not to purchase tickets at noon because they tend to be around $414. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Detroit Metropolitan Wayne County to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit Metropolitan Wayne County - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $333 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit Metropolitan Wayne County Airport for as low as $265 on momondo.

What cabin class options are available on Detroit Metropolitan Wayne County to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Detroit Metropolitan Wayne County Airport to South Carolina.

Cheap Detroit Metropolitan Wayne County Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to South Carolina

Best Price Found	$110
Fastest flight time	1h 42m
Direct flights	Every day
Airports in South Carolina	2 airports

The best one-way flight to South Carolina from Detroit Metropolitan Wayne County Airport in the past 72 hours is $110. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to South Carolina found on momondo in the last 72 hours is $299.

The fastest flight from Detroit Metropolitan Wayne County Airport to South Carolina takes 1h 42m

Direct flights go from Detroit Metropolitan Wayne County Airport to South Carolina every day.

There are 2 airports near South Carolina: Greenville (GSP), Charlotte Douglas (CLT)

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When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina?
Prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina were last updated today.
How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to South Carolina?
The number of operators available for flights from Detroit Metropolitan Wayne County Airport to South Carolina is 6 as of November 2025.
How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South Carolina?
Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to South Carolina.
What documentation or ID do you need to fly to South Carolina?
The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.
What is the most popular plane model from Detroit Metropolitan Wayne County Airport to South Carolina?
momondo data reveals that the most frequently booked plane model on the route from Detroit Metropolitan Wayne County Airport to South Carolina is Airbus A320-100/200, representing 25.14% of all bookings. The subsequent popular models are Boeing 717-200 at 22.16%, Canadair (Bombardier) Regional Jet 900 at 19.98%, and Airbus A320 (sharklets) at 9.18%.

Best airlines flying from Detroit Metropolitan Wayne County Airport to South Carolina

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to South Carolina with momondo

Airline	Rating	Free Cancellation	Price
Spirit Airlines	PriceFrom $76	Free Cancellation	Rating 6.3 8,113 reviews	Search Spirit Airlines flights
Delta	PriceFrom $159	Free Cancellation	Rating 7.9 8,003 reviews	Search Delta flights
American Airlines	PriceFrom $197	Free Cancellation	Rating 7.2 11,040 reviews	Search American Airlines flights
Southwest	PriceFrom $231	Free Cancellation	Rating 8.0 4,239 reviews	Search Southwest flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

Flights from Detroit to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Detroit to South Carolina.

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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Detroit Metropolitan Wayne County Airport flight routes

Flights from Detroit Metropolitan Wayne County to Baltimore/Washington

Flights from Detroit Metropolitan Wayne County to Nashville Intl

Flights from Detroit Metropolitan Wayne County to New York LaGuardia

Flights from Detroit Metropolitan Wayne County to Wilmington New Hanover County

Flights from Detroit Metropolitan Wayne County to Newark

Flights from Detroit Metropolitan Wayne County to Boston Logan Intl

Cheap flights from Detroit Metropolitan Wayne County Airport to South Carolina from $39

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina

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Delta flights from Detroit Metropolitan Wayne County Airport to South Carolina

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American Airlines flights from Detroit Metropolitan Wayne County Airport to South Carolina

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets

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Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

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How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Friday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $301. The most expensive day to fly to South Carolina is Sunday, with ticket prices averaging around $483.

What is the cheapest time of day to depart on your flight to South Carolina?

What is the cheapest Detroit Metropolitan Wayne County to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit Metropolitan Wayne County - South Carolina flight prices

How far in advance should I book a flight to South Carolina?

What cabin class options are available on Detroit Metropolitan Wayne County to South Carolina flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to South Carolina flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Detroit Metropolitan Wayne County Airport to South Carolina.

What is the cheapest airline that flies from Detroit Metropolitan Wayne County to South Carolina?

Frontier and Spirit Airlines are the most popular carriers operating from Detroit Metropolitan Wayne County to South Carolina

What airlines fly to South Carolina?

How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per day?

As of November 2025, 29 flights take off from Detroit Metropolitan Wayne County Airport and land in South Carolina each day. The most common flight departure time for this route is 4:00PM, with 57% of daily flights taking off in the afternoon.

How many flights depart from Detroit Metropolitan Wayne County Airport to South Carolina on average per week?

As of November 2025, there are 208 flights per week flying from Detroit Metropolitan Wayne County Airport to South Carolina. The most common day of the week flights depart is Mon, with 20% of flights taking off on this day.

Cheap Detroit Metropolitan Wayne County Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to South Carolina

Best Price Found

Fastest flight time

Direct flights

Airports in South Carolina

When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina?

How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to South Carolina?

How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

What documentation or ID do you need to fly to South Carolina?

What is the most popular plane model from Detroit Metropolitan Wayne County Airport to South Carolina?

Best airlines flying from Detroit Metropolitan Wayne County Airport to South Carolina

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to South Carolina with momondo

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

How can momondo help me find flights from Detroit to South Carolina?

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

An easier way to manage your South Carolina trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.

Find better results for your trip to South Carolina

Popular cities in South Carolina

Popular flights according to clicks in the last 7 days on momondo