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Cheap flights from Detroit Metropolitan Wayne County Airport to South Carolina from $70

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to South Carolina departing on 7/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to South Carolina

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:00 am - 7:57 am
DTW
-
GSP
20h 57m
1 stop
Multiple Airlines Logo
8:37 am - 1:07 pm
GSP
-
DTW
28h 30m
1 stop
$196Multiple Airlines
Wed, Jul 8 - Sun, Jul 12
Multiple Airlines Logo
11:00 am - 8:12 pm
DTW
-
GSP
9h 12m
1 stop
Multiple Airlines Logo
3:31 pm - 1:07 pm
GSP
-
DTW
21h 36m
1 stop
$234Multiple Airlines
Sun, Jul 19 - Fri, Jul 24
Frontier Logo
8:52 am - 4:00 pm
DTW
-
CLT
7h 08m
1 stop
Frontier Logo
9:00 am - 11:49 am
CLT
-
DTW
26h 49m
1 stop
$236Frontier
Thu, May 28 - Sun, May 31
Frontier Logo
8:52 am - 4:00 pm
DTW
-
CLT
7h 08m
1 stop
Frontier Logo
5:58 pm - 6:43 pm
CLT
-
DTW
24h 45m
1 stop
$238Frontier
Thu, Jun 4 - Sun, Jun 7
Multiple Airlines Logo
11:00 am - 7:57 am
DTW
-
GSP
20h 57m
1 stop
Multiple Airlines Logo
3:51 pm - 1:07 pm
GSP
-
DTW
21h 16m
2 stops
$239Multiple Airlines
Wed, Jul 8 - Sun, Jul 12
American Airlines Logo
5:29 pm - 10:49 pm
DTW
-
CAE
5h 20m
1 stop
American Airlines Logo
8:30 pm - 12:33 am
CAE
-
DTW
4h 03m
1 stop
$305American Airlines
Wed, Jun 17 - Tue, Jun 23
Delta Logo
7:25 am - 1:02 pm
DTW
-
CAE
5h 37m
1 stop
Delta Logo
5:35 am - 9:26 am
CAE
-
DTW
3h 51m
1 stop
$307Delta
Sat, Jul 4 - Sun, Jul 5
American Airlines Logo
5:36 am - 1:23 pm
DTW
-
CAE
7h 47m
1 stop
American Airlines Logo
3:12 pm - 10:49 pm
CAE
-
DTW
7h 37m
1 stop
$309American Airlines
Fri, Jul 3 - Mon, Jul 6
Delta Logo
6:15 am - 11:11 am
DTW
-
CAE
4h 56m
1 stop
Delta Logo
7:41 pm - 12:59 am
CAE
-
DTW
5h 18m
1 stop
$324Delta
Thu, Jun 4 - Mon, Jun 8
Southwest Logo
3:50 pm - 8:35 pm
DTW
-
SAV
4h 45m
1 stop
Southwest Logo
1:15 pm - 9:00 pm
SAV
-
DTW
7h 45m
2 stops
$364Southwest
Tue, Jun 30 - Fri, Jul 3

Frontier flights from Detroit Metropolitan Wayne County Airport to South Carolina

Our best Frontier deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets
Frontier
May 28
DTW8:52 amDetroit Metropolitan Wayne County
7h 08m
1 stop
CLT4:00 pmCharlotte Douglas
May 31
CLT9:00 amCharlotte Douglas
26h 49m
1 stop
DTW11:49 amDetroit Metropolitan Wayne County
$236
Frontier
Jun 4
DTW8:52 amDetroit Metropolitan Wayne County
7h 08m
1 stop
CLT4:00 pmCharlotte Douglas
Jun 7
CLT5:58 pmCharlotte Douglas
24h 45m
1 stop
DTW6:43 pmDetroit Metropolitan Wayne County
$238
Frontier
Jul 10
DTW7:25 pmDetroit Metropolitan Wayne County
16h 04m
1 stop
CLT11:29 amCharlotte Douglas
Jul 12
CLT1:19 pmCharlotte Douglas
22h 23m
1 stop
DTW11:42 amDetroit Metropolitan Wayne County
$240

Southwest flights from Detroit Metropolitan Wayne County Airport to South Carolina

Our best Southwest deals on Detroit Metropolitan Wayne County Airport to South Carolina flight tickets
Southwest
May 27
DTW4:10 pmDetroit Metropolitan Wayne County
5h 30m
1 stop
CLT9:40 pmCharlotte Douglas
May 29
CLT7:20 pmCharlotte Douglas
4h 10m
1 stop
DTW11:30 pmDetroit Metropolitan Wayne County
$323
Southwest
May 27
DTW1:40 pmDetroit Metropolitan Wayne County
8h 00m
2 stops
CLT9:40 pmCharlotte Douglas
May 29
CLT7:20 pmCharlotte Douglas
4h 10m
1 stop
DTW11:30 pmDetroit Metropolitan Wayne County
$328
Southwest
Jul 9
DTW1:25 pmDetroit Metropolitan Wayne County
8h 30m
2 stops
CHS9:55 pmCharleston
Jul 12
CHS7:05 amCharleston
5h 10m
1 stop
DTW12:15 pmDetroit Metropolitan Wayne County
$364

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 18, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 7/8

11:00 am-7:57 am

1 stop20h 57m

Greenville

Sun 7/12

8:37 am-1:07 pm

1 stop28h 30m

$196

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Sun 7/19

11:00 am-8:12 pm

1 stop9h 12m

Greenville

Fri 7/24

3:31 pm-1:07 pm

1 stop21h 36m

$234

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 5/28

8:52 am-4:00 pm

1 stop7h 08m

Charlotte Douglas

Sun 5/31

9:00 am-11:49 am

1 stop26h 49m

$236

DetroitCharlotte

DTW - CLT

DTWCLT

Detroit Metropolitan Wayne County

Thu 6/4

8:52 am-4:00 pm

1 stop7h 08m

Charlotte Douglas

Sun 6/7

5:58 pm-6:43 pm

1 stop24h 45m

$238

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 7/8

11:00 am-7:57 am

1 stop20h 57m

Greenville

Sun 7/12

3:51 pm-1:07 pm

2 stops21h 16m

$239
Quickest round-trip

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Wed 6/17

5:29 pm-10:49 pm

1 stop5h 20m

Columbia Metropolitan

Tue 6/23

8:30 pm-12:33 am

1 stop4h 03m

$305

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Sat 7/4

7:25 am-1:02 pm

1 stop5h 37m

Columbia Metropolitan

Sun 7/5

5:35 am-9:26 am

1 stop3h 51m

$307

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Fri 7/3

5:36 am-1:23 pm

1 stop7h 47m

Columbia Metropolitan

Mon 7/6

3:12 pm-10:49 pm

1 stop7h 37m

$309

DetroitColumbia

DTW - CAE

DTWCAE

Detroit Metropolitan Wayne County

Thu 6/4

6:15 am-11:11 am

1 stop4h 56m

Columbia Metropolitan

Mon 6/8

7:41 pm-12:59 am

1 stop5h 18m

$324

DetroitSavannah

DTW - SAV

DTWSAV

Detroit Metropolitan Wayne County

Tue 6/30

3:50 pm-8:35 pm

1 stop4h 45m

Savannah/Hilton Head

Fri 7/3

1:15 pm-9:00 pm

2 stops7h 45m

$364

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to South Carolina from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Detroit Metropolitan Wayne County Airport is in August. Flight prices, which tend to average around $45, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of August, then book flights to South Carolina from Detroit Metropolitan Wayne County Airport during July instead. Flights to South Carolina in July, while not as cheap as those in August, still average around $61.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $299. The most expensive day to fly to South Carolina is Friday, with ticket prices averaging around $380.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Detroit Metropolitan Wayne County Airport to South Carolina flights are usually those with departure times at noon. Our users have found flights to South Carolina at noon for as low as $299. Try not to purchase tickets in the evening because they tend to be around $408. Of course, these prices can vary depending on the time of year and what airport you fly to.

What is the cheapest Detroit Metropolitan Wayne County to South Carolina flight route?

Fly from Detroit Metropolitan Wayne County to Myrtle Beach Intl for the best Detroit Metropolitan Wayne County - South Carolina flight prices

How far in advance should I book a flight from Detroit Metropolitan Wayne County Airport to South Carolina?

You are more likely to see cheaper flights to South Carolina from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $370 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Detroit Metropolitan Wayne County Airport for as low as $242 on momondo.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to South Carolina flights?

No. A direct flight is the cheapest option for a flight between Detroit Metropolitan Wayne County Airport to South Carolina.

Cheap Detroit Metropolitan Wayne County Airport to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to South Carolina

Best Price Found

$218

Fastest flight time

1h 39m

Direct flights

Every day

Airports in South Carolina

57 airports
The best one-way flight to South Carolina from Detroit Metropolitan Wayne County Airport in the past 72 hours is $218. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to South Carolina found on momondo in the last 72 hours is $339.
The fastest flight from Detroit Metropolitan Wayne County Airport to South Carolina takes 1h 39m
Direct flights go from Detroit Metropolitan Wayne County Airport to South Carolina every day.
There are 57 airports in South Carolina. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP), Myrtle Beach Intl (MYR), Savannah/Hilton Head (SAV), Charlotte Douglas (CLT).
Search flight deals

Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to South Carolina

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina?

    Prices for flights from Detroit Metropolitan Wayne County Airport to South Carolina were last updated today.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to South Carolina?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South Carolina?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The required travel and health documents for your South Carolina trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at South Carolina. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to South Carolina?

Best airlines flying from Detroit Metropolitan Wayne County Airport to South Carolina

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $64Free CancellationRating
6.2
8,615 reviews
Search Spirit Airlines flights
DeltaPriceFrom $165Free CancellationRating
7.9
8,452 reviews
Search Delta flights
SouthwestPriceFrom $207Free CancellationRating
7.9
4,285 reviews
Search Southwest flights
American AirlinesPriceFrom $218Free CancellationRating
7.1
11,646 reviews
Search American Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South Carolina?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to South Carolina. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to South Carolina with flexible booking policies on momondo?

Flights from Detroit to South Carolina with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Detroit to South Carolina?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Detroit to South Carolina.

I’m not ready to book a flight from Detroit to South Carolina right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to South Carolina flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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