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Cheap flights from Detroit Metropolitan Wayne County Airport to South America from $93

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to South America departing on 4/13. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
6:50 pm - 1:22 pm
DTW
-
MDE
19h 32m
1 stop
Multiple Airlines Logo
2:06 pm - 12:46 am
MDE
-
DTW
9h 40m
1 stop
$326Multiple Airlines
Mon, Apr 13 - Fri, Apr 17
Spirit Airlines Logo
4:17 pm - 12:21 am
DTW
-
MDE
9h 04m
1 stop
Spirit Airlines Logo
1:17 am - 3:12 pm
MDE
-
DTW
12h 55m
1 stop
$344Spirit Airlines
Thu, Apr 9 - Mon, Apr 13
Multiple Airlines Logo
3:57 pm - 1:12 pm
DTW
-
BOG
22h 15m
1 stop
Multiple Airlines Logo
2:07 pm - 9:10 am
BOG
-
DTW
42h 03m
2 stops
$358Multiple Airlines
Fri, Apr 17 - Sat, May 2
Spirit Airlines Logo
8:15 am - 12:21 am
DTW
-
MDE
17h 06m
1 stop
Spirit Airlines Logo
2:06 pm - 5:18 pm
MDE
-
DTW
26h 12m
2 stops
$358Spirit Airlines
Mon, Apr 13 - Fri, Apr 17
Multiple Airlines Logo
8:49 pm - 12:06 pm
DTW
-
CTG
40h 17m
2 stops
Multiple Airlines Logo
1:11 pm - 11:59 pm
CTG
-
DTW
9h 48m
1 stop
$359Multiple Airlines
Fri, Apr 24 - Fri, May 1
Air Canada Logo
10:15 am - 9:50 am
DTW
-
GRU
22h 35m
1 stop
Air Canada Logo
9:35 pm - 10:08 am
GRU
-
DTW
13h 33m
1 stop
$816Air Canada
Tue, May 12 - Tue, May 19
GOL Logo
6:19 am - 10:45 am
DTW
-
GIG
27h 26m
2 stops
GOL Logo
10:30 pm - 10:52 pm
GIG
-
DTW
25h 22m
2 stops
$933GOL
Mon, Aug 31 - Mon, Sep 21
Air Canada Logo
10:15 am - 2:30 pm
DTW
-
EZE
27h 15m
2 stops
Air Canada Logo
4:35 pm - 9:25 pm
EZE
-
DTW
53h 50m
3 stops
$964Air Canada
Wed, May 20 - Wed, Jun 3
Azul Logo
10:15 am - 2:30 pm
DTW
-
EZE
27h 15m
2 stops
Azul Logo
4:35 pm - 9:25 pm
EZE
-
DTW
53h 50m
2 stops
$984Azul
Wed, May 20 - Wed, Jun 3
GOL Logo
6:19 am - 4:40 pm
DTW
-
SDU
33h 21m
2 stops
GOL Logo
6:00 am - 10:52 pm
SDU
-
DTW
17h 52m
2 stops
$1,016GOL
Thu, Sep 3 - Sun, Sep 27

Spirit Airlines flights from Detroit Metropolitan Wayne County Airport to South America

Our best Spirit Airlines deals on Detroit Metropolitan Wayne County Airport to South America flight tickets
Spirit Airlines
Apr 9
DTW6:50 pmDetroit Metropolitan Wayne County
19h 21m
1 stop
BOG1:11 pmBogotá El Dorado
Apr 14
BOG2:10 pmBogotá El Dorado
8h 49m
1 stop
DTW11:59 pmDetroit Metropolitan Wayne County
$334
Spirit Airlines
Apr 9
DTW4:17 pmDetroit Metropolitan Wayne County
9h 04m
1 stop
MDE12:21 amMedellín Jose Maria Cordova Intl
Apr 13
MDE1:17 amMedellín Jose Maria Cordova Intl
12h 55m
1 stop
DTW3:12 pmDetroit Metropolitan Wayne County
$344
Spirit Airlines
Apr 10
DTW6:50 pmDetroit Metropolitan Wayne County
18h 16m
1 stop
CTG12:06 pmCartagena Rafael Nunez
Apr 14
CTG1:14 pmCartagena Rafael Nunez
8h 18m
1 stop
DTW10:32 pmDetroit Metropolitan Wayne County
$348

American Airlines flights from Detroit Metropolitan Wayne County Airport to South America

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to South America flight tickets
American Airlines
May 29
DTW6:04 amDetroit Metropolitan Wayne County
17h 33m
1 stop
GYE10:37 pmGuayaquil Jose Joaquin de Olmedo
Jun 6
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
16h 56m
1 stop
DTW11:56 pmDetroit Metropolitan Wayne County
$665
American Airlines
May 29
DTW7:58 pmDetroit Metropolitan Wayne County
18h 33m
2 stops
GYE1:31 pmGuayaquil Jose Joaquin de Olmedo
Jun 6
GYE6:00 amGuayaquil Jose Joaquin de Olmedo
16h 56m
1 stop
DTW11:56 pmDetroit Metropolitan Wayne County
$670
American Airlines
Sep 13
DTW7:56 pmDetroit Metropolitan Wayne County
24h 04m
2 stops
GYE7:00 pmGuayaquil Jose Joaquin de Olmedo
Sep 22
GYE8:20 amGuayaquil Jose Joaquin de Olmedo
12h 42m
2 stops
DTW10:02 pmDetroit Metropolitan Wayne County
$721

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitMedellín

DTW - MDE

DTWMDE

Detroit Metropolitan Wayne County

Mon 4/13

6:50 pm-1:22 pm

1 stop19h 32m

Medellín Jose Maria Cordova Intl

Fri 4/17

2:06 pm-12:46 am

1 stop9h 40m

$326
Quickest round-trip

DetroitMedellín

DTW - MDE

DTWMDE

Detroit Metropolitan Wayne County

Thu 4/9

4:17 pm-12:21 am

1 stop9h 04m

Medellín Jose Maria Cordova Intl

Mon 4/13

1:17 am-3:12 pm

1 stop12h 55m

$344

DetroitBogotá

DTW - BOG

DTWBOG

Detroit Metropolitan Wayne County

Fri 4/17

3:57 pm-1:12 pm

1 stop22h 15m

Bogotá El Dorado

Sat 5/2

2:07 pm-9:10 am

2 stops42h 03m

$358

DetroitMedellín

DTW - MDE

DTWMDE

Detroit Metropolitan Wayne County

Mon 4/13

8:15 am-12:21 am

1 stop17h 06m

Medellín Jose Maria Cordova Intl

Fri 4/17

2:06 pm-5:18 pm

2 stops26h 12m

$358

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Fri 4/24

8:49 pm-12:06 pm

2 stops40h 17m

Cartagena Rafael Nunez

Fri 5/1

1:11 pm-11:59 pm

1 stop9h 48m

$359

DetroitSao Paulo

DTW - GRU

DTWGRU

Detroit Metropolitan Wayne County

Tue 5/12

10:15 am-9:50 am

1 stop22h 35m

Sao Paulo Guarulhos Intl

Tue 5/19

9:35 pm-10:08 am

1 stop13h 33m

$816

DetroitRio de Janeiro

DTW - GIG

DTWGIG

Detroit Metropolitan Wayne County

Mon 8/31

6:19 am-10:45 am

2 stops27h 26m

Rio de Janeiro–Galeão Intl

Mon 9/21

10:30 pm-10:52 pm

2 stops25h 22m

$933

DetroitBuenos Aires

DTW - EZE

DTWEZE

Detroit Metropolitan Wayne County

Wed 5/20

10:15 am-2:30 pm

2 stops27h 15m

Buenos Aires Ministro Pistarini

Wed 6/3

4:35 pm-9:25 pm

3 stops53h 50m

$964

DetroitBuenos Aires

DTW - EZE

DTWEZE

Detroit Metropolitan Wayne County

Wed 5/20

10:15 am-2:30 pm

2 stops27h 15m

Buenos Aires Ministro Pistarini

Wed 6/3

4:35 pm-9:25 pm

2 stops53h 50m

$984

DetroitRio de Janeiro

DTW - SDU

DTWSDU

Detroit Metropolitan Wayne County

Thu 9/3

6:19 am-4:40 pm

2 stops33h 21m

Rio de Janeiro Santos Dumont

Sun 9/27

6:00 am-10:52 pm

2 stops17h 52m

$1,016

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, February is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $504. If you aren’t able to travel during the month of February, then book flights to South America from Detroit Metropolitan Wayne County Airport during April instead. Flights to South America in April, while not as cheap as those in February, still average around $507.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $847 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Detroit Metropolitan Wayne County Airport for as low as $555 on momondo.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to South America flights?

You could potentially save up to 27% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to South America flight.

Cheap Detroit Metropolitan Wayne County Airport to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to South America

Fastest flight time

7h 26m

Direct flights

None
The fastest flight from Detroit Metropolitan Wayne County Airport to South America takes 7h 26m
There are no direct flights from Detroit Metropolitan Wayne County Airport to South America. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to South America.
Search flight deals

Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to South America

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to South America?

    Prices for flights from Detroit Metropolitan Wayne County Airport to South America were last updated today.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to South America?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Detroit Metropolitan Wayne County Airport to South America

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $266Free CancellationRating
6.3
8,577 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $417Free CancellationRating
7.1
11,549 reviews
Search American Airlines flights
DeltaPriceFrom $563Free CancellationRating
7.9
8,367 reviews
Search Delta flights
LATAM AirlinesPriceFrom $643Free CancellationRating
7.4
1,907 reviews
Search LATAM Airlines flights
Copa AirlinesPriceFrom $650Free CancellationRating
7.5
1,578 reviews
Search Copa Airlines flights
Air CanadaPriceFrom $773Free CancellationRating
7.1
10,880 reviews
Search Air Canada flights
United AirlinesPriceFrom $1,078Free CancellationRating
7.4
9,533 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South America?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to South America. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to South America with flexible booking policies on momondo?

All flight searches from Detroit to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to South America?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South America from Detroit.

I’m not ready to book a flight from Detroit to South America right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South America, momondo offers a useful price alert feature which will track prices for flights to South America from Detroit and alert you when they change.

An easier way to manage your South America trip

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Find better results for your trip to South America

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Popular flights according to clicks in the last 7 days on momondo
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