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Cheap flights from Detroit Metropolitan Wayne County Airport to South America from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to South America departing on 1/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to South America

Cheap round-trip flights

Enter your travel dates to find the best prices.
Spirit Airlines Logo
6:11 am - 1:08 pmDTW-CTG
6h 57m1 stop
Spirit Airlines Logo
2:16 pm - 12:25 amCTG-DTW
10h 09m1 stop
$281Spirit Airlines
Find Deal
Tue, Jan 27 - Tue, Feb 3
Spirit Airlines Logo
9:20 pm - 1:08 pmDTW-CTG
15h 48m2 stops
Spirit Airlines Logo
2:16 pm - 12:25 amCTG-DTW
10h 09m1 stop
$297Spirit Airlines
Find Deal
Tue, Jan 27 - Tue, Feb 3
Air Canada Logo
6:15 pm - 6:10 amDTW-LIM
11h 55m1 stop
Air Canada Logo
8:00 am - 5:35 pmLIM-DTW
32h 35m1 stop
$493Air Canada
Find Deal
Wed, Mar 4 - Sun, Mar 15
Air Canada Logo
6:15 pm - 6:10 amDTW-LIM
11h 55m1 stop
Air Canada Logo
8:00 am - 5:35 pmLIM-DTW
32h 35m1 stop
$513Air Canada
Find Deal
Fri, Feb 27 - Sun, Mar 15
Copa Airlines Logo
9:15 am - 8:06 amDTW-CTG
22h 51m2 stops
Copa Airlines Logo
9:22 am - 10:06 amCTG-DTW
24h 44m2 stops
$525Copa Airlines
Find Deal
Wed, Nov 12 - Mon, Nov 17
American Airlines Logo
1:20 pm - 8:15 amDTW-SCL
16h 55m1 stop
American Airlines Logo
11:15 pm - 4:32 pmSCL-DTW
19h 17m1 stop
$864American Airlines
Find Deal
Tue, Jan 6 - Tue, Jan 20
American Airlines Logo
11:30 am - 8:15 amDTW-SCL
18h 45m2 stops
American Airlines Logo
11:15 pm - 2:01 pmSCL-DTW
16h 46m2 stops
$869American Airlines
Find Deal
Tue, Jan 6 - Tue, Jan 20
Copa Airlines Logo
9:10 am - 8:00 amDTW-GIG
20h 50m2 stops
Copa Airlines Logo
1:40 am - 8:26 pmGIG-DTW
19h 46m2 stops
$905Copa Airlines
Find Deal
Tue, Mar 3 - Mon, Mar 23
United Airlines Logo
7:25 am - 8:50 amDTW-SCL
23h 25m2 stops
United Airlines Logo
10:45 pm - 1:06 pmSCL-DTW
16h 21m2 stops
$909United Airlines
Find Deal
Fri, Dec 12 - Mon, Dec 15
United Airlines Logo
11:05 am - 8:50 amDTW-SCL
43h 45m2 stops
United Airlines Logo
10:45 pm - 11:43 pmSCL-DTW
26h 58m1 stop
$936United Airlines
Find Deal
Sun, Dec 14 - Sun, Dec 21

Spirit Airlines flights from Detroit Metropolitan Wayne County Airport to South America

Our best Spirit Airlines deals on Detroit Metropolitan Wayne County Airport to South America flight tickets
Spirit Airlines
Jan 27
DTW6:11 amDetroit Metropolitan Wayne County
6h 57m
1 stop
CTG1:08 pmCartagena Rafael Nunez
Feb 3
CTG2:16 pmCartagena Rafael Nunez
10h 09m
1 stop
DTW12:25 amDetroit Metropolitan Wayne County
$281
Find similar
Spirit Airlines
Jan 27
DTW9:20 pmDetroit Metropolitan Wayne County
15h 48m
2 stops
CTG1:08 pmCartagena Rafael Nunez
Feb 3
CTG2:16 pmCartagena Rafael Nunez
10h 09m
1 stop
DTW12:25 amDetroit Metropolitan Wayne County
$297
Find similar
Spirit Airlines
Dec 9
DTW5:55 pmDetroit Metropolitan Wayne County
7h 14m
1 stop
MDE1:09 amMedellín Jose Maria Cordova Intl
Dec 15
MDE2:05 amMedellín Jose Maria Cordova Intl
8h 03m
1 stop
DTW10:08 amDetroit Metropolitan Wayne County
$300
Find similar

Delta flights from Detroit Metropolitan Wayne County Airport to South America

Our best Delta deals on Detroit Metropolitan Wayne County Airport to South America flight tickets
Delta
Nov 13
DTW8:05 amDetroit Metropolitan Wayne County
12h 15m
2 stops
BOG8:20 pmBogotá El Dorado
Dec 1
BOG3:55 pmBogotá El Dorado
17h 35m
1 stop
DTW9:30 amDetroit Metropolitan Wayne County
$828
Find similar
Delta
Nov 12
DTW7:05 amDetroit Metropolitan Wayne County
13h 15m
2 stops
BOG8:20 pmBogotá El Dorado
Nov 30
BOG7:00 amBogotá El Dorado
15h 04m
2 stops
DTW10:04 pmDetroit Metropolitan Wayne County
$2,182
Find similar
Delta
Nov 2
DTW1:31 pmDetroit Metropolitan Wayne County
13h 49m
1 stop
GRU5:20 amSao Paulo Guarulhos Intl
Nov 5
GRU4:00 amSao Paulo Guarulhos Intl
18h 31m
2 stops
DTW8:31 pmDetroit Metropolitan Wayne County
$7,886
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momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Tue 1/27

6:11 am-1:08 pm

1 stop6h 57m

Cartagena Rafael Nunez

Tue 2/3

2:16 pm-12:25 am

1 stop10h 09m

$281

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Tue 1/27

9:20 pm-1:08 pm

2 stops15h 48m

Cartagena Rafael Nunez

Tue 2/3

2:16 pm-12:25 am

1 stop10h 09m

$297

DetroitLima

DTW - LIM

DTWLIM

Detroit Metropolitan Wayne County

Wed 3/4

6:15 pm-6:10 am

1 stop11h 55m

Lima J Chavez Intl

Sun 3/15

8:00 am-5:35 pm

1 stop32h 35m

$493

DetroitLima

DTW - LIM

DTWLIM

Detroit Metropolitan Wayne County

Fri 2/27

6:15 pm-6:10 am

1 stop11h 55m

Lima J Chavez Intl

Sun 3/15

8:00 am-5:35 pm

1 stop32h 35m

$513

DetroitCartagena

DTW - CTG

DTWCTG

Detroit Metropolitan Wayne County

Wed 11/12

9:15 am-8:06 am

2 stops22h 51m

Cartagena Rafael Nunez

Mon 11/17

9:22 am-10:06 am

2 stops24h 44m

$525

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 1/6

1:20 pm-8:15 am

1 stop16h 55m

Santiago Arturo Merino Benitez

Tue 1/20

11:15 pm-4:32 pm

1 stop19h 17m

$864

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Tue 1/6

11:30 am-8:15 am

2 stops18h 45m

Santiago Arturo Merino Benitez

Tue 1/20

11:15 pm-2:01 pm

2 stops16h 46m

$869

DetroitRio de Janeiro

DTW - GIG

DTWGIG

Detroit Metropolitan Wayne County

Tue 3/3

9:10 am-8:00 am

2 stops20h 50m

Rio de Janeiro–Galeão Intl

Mon 3/23

1:40 am-8:26 pm

2 stops19h 46m

$905

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Fri 12/12

7:25 am-8:50 am

2 stops23h 25m

Santiago Arturo Merino Benitez

Mon 12/15

10:45 pm-1:06 pm

2 stops16h 21m

$909

DetroitSantiago

DTW - SCL

DTWSCL

Detroit Metropolitan Wayne County

Sun 12/14

11:05 am-8:50 am

2 stops43h 45m

Santiago Arturo Merino Benitez

Sun 12/21

10:45 pm-11:43 pm

1 stop26h 58m

$936

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to South America

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South America?

In general, January is the cheapest month to fly from Detroit Metropolitan Wayne County Airport to South America. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $795. If you aren’t able to travel during the month of January, then book flights to South America from Detroit Metropolitan Wayne County Airport during February instead. Flights to South America in February, while not as cheap as those in January, still average around $824.

What is the cheapest day to depart on your flight to South America?

The cheapest day to depart from Detroit Metropolitan Wayne County Airport to South America is on a Tuesday when prices can be found for as low as $793. When flying out on a Saturday, the most expensive travel day of the week, you can expect to see flight prices from Detroit Metropolitan Wayne County Airport to South America for around $999.

What is the cheapest time of day to depart on your flight to South America?

Our data shows that the cheapest Detroit Metropolitan Wayne County Airport to South America flights are usually those with departure times in the morning. Our users have found flights to South America in the morning for as low as $923. If you have a flexible travel schedule, then try to avoid flying in the afternoon when prices are $954 on average. Flights to South America from Detroit Metropolitan Wayne County Airport in the afternoon are generally more expensive because this time of day is more convenient for travelers’ schedules.

How far in advance should I book a flight to South America?

You are more likely to see cheaper flights to South America from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to South America for around $970 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South America from Detroit Metropolitan Wayne County Airport for as low as $658 on momondo.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to South America flights?

You could potentially save up to 10% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to South America flight.

Cheap Detroit Metropolitan Wayne County Airport to South America flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to South America

Direct flights

None
There are no direct flights from Detroit Metropolitan Wayne County Airport to South America. There are no popular flight routes from Detroit Metropolitan Wayne County Airport to South America.
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  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to South America?

    Prices for flights from Detroit Metropolitan Wayne County Airport to South America were last updated today.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to South America?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to South America?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Detroit Metropolitan Wayne County Airport to South America.

  • What documentation or ID do you need to fly to South America?

    The travel and health documents you'll need for your trip to South America may differ based on your itinerary and personal situation. Typically, you should have several documents on hand, such as a national ID card or driver's license and a passport that is valid for six months after your intended arrival at South America. It is always advisable to seek advice from your airline or a trusted third party, such as IATA.

Best airlines flying from Detroit Metropolitan Wayne County Airport to South America

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to South America with momondo
Airline
Rating
Free Cancellation
Price
Spirit AirlinesPriceFrom $104Free CancellationRating
6.3
8,115 reviews
Search Spirit Airlines flights
American AirlinesPriceFrom $385Free CancellationRating
7.2
11,030 reviews
Search American Airlines flights
DeltaPriceFrom $527Free CancellationRating
7.9
7,993 reviews
Search Delta flights
United AirlinesPriceFrom $550Free CancellationRating
7.4
8,998 reviews
Search United Airlines flights
Copa AirlinesPriceFrom $583Free CancellationRating
7.6
1,563 reviews
Search Copa Airlines flights
Air CanadaPriceFrom $585Free CancellationRating
7.1
10,377 reviews
Search Air Canada flights
LATAM AirlinesPriceFrom $652Free CancellationRating
7.5
1,872 reviews
Search LATAM Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to South America?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Detroit to South America. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Detroit to South America with flexible booking policies on momondo?

All flight searches from Detroit to South America on momondo can be filtered to show those which offer flexible booking policies.

How can momondo help me find flights from Detroit to South America?

Once you have performed a search in the form on the page, momondo provides useful filters and insights. We can show you the cheapest days and times to fly as well as help filter your options to help you make an informed choice when booking flights to South America from Detroit.

I’m not ready to book a flight from Detroit to South America right now. Can momondo alert me if prices change?

If you are simply researching potential flights to South America, momondo offers a useful price alert feature which will track prices for flights to South America from Detroit and alert you when they change.

An easier way to manage your South America trip

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Find better results for your trip to South America

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Popular flights according to clicks in the last 7 days on momondo
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