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Cheap flights from Detroit Metropolitan Wayne County Airport to Greenville from $100

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Greenville departing on 3/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:45 pm - 5:32 pm
DTW
-
GSP
20h 47m
1 stop
Multiple Airlines Logo
6:22 pm - 1:30 pm
GSP
-
DTW
19h 08m
2 stops
$206Multiple Airlines
jue., feb. 19 - lun., feb. 23
Multiple Airlines Logo
8:49 am - 5:32 pm
DTW
-
GSP
8h 43m
1 stop
Multiple Airlines Logo
6:22 pm - 1:30 pm
GSP
-
DTW
19h 08m
2 stops
$207Multiple Airlines
vie., feb. 20 - lun., feb. 23
Multiple Airlines Logo
8:45 pm - 5:32 pm
DTW
-
GSP
20h 47m
1 stop
Multiple Airlines Logo
6:22 pm - 9:15 am
GSP
-
DTW
14h 53m
1 stop
$253Multiple Airlines
jue., feb. 19 - lun., feb. 23
Multiple Airlines Logo
9:02 am - 4:27 pm
DTW
-
GSP
7h 25m
1 stop
Multiple Airlines Logo
5:17 pm - 3:57 pm
GSP
-
DTW
22h 40m
2 stops
$271Multiple Airlines
jue., feb. 19 - dom., feb. 22
Multiple Airlines Logo
8:45 pm - 4:27 pm
DTW
-
GSP
19h 42m
1 stop
Multiple Airlines Logo
2:58 pm - 4:12 pm
GSP
-
DTW
25h 14m
2 stops
$278Multiple Airlines
sáb., feb. 21 - dom., mar. 8
Multiple Airlines Logo
8:52 pm - 1:12 pm
DTW
-
GSP
16h 20m
1 stop
Multiple Airlines Logo
6:22 pm - 1:30 pm
GSP
-
DTW
19h 08m
2 stops
$291Multiple Airlines
sáb., feb. 14 - lun., feb. 16
Multiple Airlines Logo
5:00 am - 4:53 pm
DTW
-
GSP
11h 53m
1 stop
Multiple Airlines Logo
5:43 pm - 9:25 am
GSP
-
DTW
15h 42m
1 stop
$293Multiple Airlines
vie., abr. 24 - lun., abr. 27
Multiple Airlines Logo
5:45 am - 5:53 pm
DTW
-
GSP
12h 08m
1 stop
Multiple Airlines Logo
4:41 pm - 8:07 am
GSP
-
DTW
15h 26m
2 stops
$294Multiple Airlines
vie., mar. 6 - dom., mar. 8
Multiple Airlines Logo
6:05 am - 4:53 pm
DTW
-
GSP
10h 48m
2 stops
Multiple Airlines Logo
5:43 pm - 9:25 am
GSP
-
DTW
15h 42m
1 stop
$299Multiple Airlines
vie., abr. 24 - lun., abr. 27
Multiple Airlines Logo
2:23 pm - 2:32 pm
DTW
-
GSP
24h 09m
1 stop
Multiple Airlines Logo
5:05 pm - 9:25 am
GSP
-
DTW
16h 20m
1 stop
$307Multiple Airlines
jue., may. 28 - lun., jun. 1

American Airlines flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
American Airlines
Feb 18
DTW12:00 pmDetroit Metropolitan Wayne County
10h 08m
1 stop
GSP10:08 pmGreenville
Feb 24
GSP12:55 pmGreenville
9h 42m
1 stop
DTW10:37 pmDetroit Metropolitan Wayne County
$355
American Airlines
Feb 19
DTW2:18 pmDetroit Metropolitan Wayne County
7h 47m
1 stop
GSP10:05 pmGreenville
Feb 25
GSP12:55 pmGreenville
9h 42m
1 stop
DTW10:37 pmDetroit Metropolitan Wayne County
$381
American Airlines
Apr 10
DTW5:03 pmDetroit Metropolitan Wayne County
5h 16m
1 stop
GSP10:19 pmGreenville
Apr 14
GSP12:35 pmGreenville
9h 36m
1 stop
DTW10:11 pmDetroit Metropolitan Wayne County
$382

Southwest flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Southwest deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Southwest
May 11
DTW4:00 pmDetroit Metropolitan Wayne County
6h 15m
1 stop
GSP10:15 pmGreenville
May 22
GSP6:25 pmGreenville
3h 55m
1 stop
DTW10:20 pmDetroit Metropolitan Wayne County
$392
Southwest
Apr 10
DTW12:55 pmDetroit Metropolitan Wayne County
9h 20m
2 stops
GSP10:15 pmGreenville
Apr 14
GSP1:55 pmGreenville
7h 40m
2 stops
DTW9:35 pmDetroit Metropolitan Wayne County
$402
Southwest
Apr 24
DTW12:55 pmDetroit Metropolitan Wayne County
9h 20m
2 stops
GSP10:15 pmGreenville
Apr 28
GSP12:50 pmGreenville
7h 25m
2 stops
DTW8:15 pmDetroit Metropolitan Wayne County
$408

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated febrero 2, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

jue. 2/19

8:45 pm-5:32 pm

1 stop20h 47m

Greenville

lun. 2/23

6:22 pm-1:30 pm

2 stops19h 08m

$206

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

vie. 2/20

8:49 am-5:32 pm

1 stop8h 43m

Greenville

lun. 2/23

6:22 pm-1:30 pm

2 stops19h 08m

$207

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

jue. 2/19

8:45 pm-5:32 pm

1 stop20h 47m

Greenville

lun. 2/23

6:22 pm-9:15 am

1 stop14h 53m

$253

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

jue. 2/19

9:02 am-4:27 pm

1 stop7h 25m

Greenville

dom. 2/22

5:17 pm-3:57 pm

2 stops22h 40m

$271

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

sáb. 2/21

8:45 pm-4:27 pm

1 stop19h 42m

Greenville

dom. 3/8

2:58 pm-4:12 pm

2 stops25h 14m

$278

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

sáb. 2/14

8:52 pm-1:12 pm

1 stop16h 20m

Greenville

lun. 2/16

6:22 pm-1:30 pm

2 stops19h 08m

$291

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

vie. 4/24

5:00 am-4:53 pm

1 stop11h 53m

Greenville

lun. 4/27

5:43 pm-9:25 am

1 stop15h 42m

$293

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

vie. 3/6

5:45 am-5:53 pm

1 stop12h 08m

Greenville

dom. 3/8

4:41 pm-8:07 am

2 stops15h 26m

$294

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

vie. 4/24

6:05 am-4:53 pm

2 stops10h 48m

Greenville

lun. 4/27

5:43 pm-9:25 am

1 stop15h 42m

$299

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

jue. 5/28

2:23 pm-2:32 pm

1 stop24h 09m

Greenville

lun. 6/1

5:05 pm-9:25 am

1 stop16h 20m

$307

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
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See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of June is another great option to travel to Greenville, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $399.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Thursday departure recently was $439. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $693. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Greenville during this time can be as low as $459. Flights to Greenville are more costly in the evening, with an average ticket price of $564. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit Metropolitan Wayne County to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit Metropolitan Wayne County - Greenville flight prices

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $462 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Detroit Metropolitan Wayne County Airport for as low as $293 on momondo.

What cabin class options are available on Detroit Metropolitan Wayne County to Greenville flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Greenville flights?

You could potentially save up to 62% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Greenville flight.

How have Detroit Metropolitan Wayne County Airport to Greenville flight prices changed over time?

As of February 2026, prices for Detroit Metropolitan Wayne County Airport to Greenville flights are approximately 43% more expensive when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Greenville (DTW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Greenville

Best Price Found

$333

Fastest flight time

1h 39m

Direct flights

Tue, Wed, Thu, Fri, Sat and Sun

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $333. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Greenville found on momondo in the last 72 hours is $399.
The fastest flight from Detroit Metropolitan Wayne County Airport to Greenville takes 1h 39m
Direct flights go from Detroit Metropolitan Wayne County Airport to Greenville on Tuesday, Wednesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is Delta.
There is 1 airport in Greenville. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP).
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Greenville by plane?

    The distance between Detroit Metropolitan Wayne County and Greenville is about 511.4 mi. By plane, this route typically takes 1h 39m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Greenville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Greenville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Greenville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $226Free CancellationRating
7.2
11,212 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,271 reviews
Search Southwest flights
DeltaPriceFrom $399Free CancellationRating
7.9
8,131 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Greenville

    Delta flies from Detroit Metropolitan Wayne County Airport to Greenville around 11 times per week, with 8,131 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Greenville in the last 72 hours was $399 (round-trip), much lower than the average airfare cost of $522 for Delta flights on this route.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Greenville?

Once all potential Detroit to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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