Latest deals
Insights
When to book
FAQs
Reviews
Price Alerts

Cheap flights from Detroit Metropolitan Wayne County Airport to Greenville from $127

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Greenville departing on 4/19. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Save money when you book flights with momondo

Big names and deals

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Price Alerts

Not ready to book? to track prices.
Search flight deals

Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
1:28 pm - 7:38 pm
DTW
-
GSP
6h 10m
1 stop
Multiple Airlines Logo
5:43 pm - 12:39 am
GSP
-
DTW
6h 56m
1 stop
$247Multiple Airlines
Mon, Apr 6 - Fri, Apr 10
Multiple Airlines Logo
6:10 am - 4:53 pm
DTW
-
GSP
10h 43m
1 stop
Multiple Airlines Logo
5:43 pm - 6:07 pm
GSP
-
DTW
24h 24m
2 stops
$262Multiple Airlines
Mon, Apr 20 - Mon, Apr 27
Multiple Airlines Logo
5:05 am - 7:38 pm
DTW
-
GSP
14h 33m
1 stop
Multiple Airlines Logo
5:43 pm - 12:39 am
GSP
-
DTW
6h 56m
1 stop
$270Multiple Airlines
Mon, Apr 6 - Fri, Apr 10
Multiple Airlines Logo
6:10 am - 4:53 pm
DTW
-
GSP
10h 43m
1 stop
Multiple Airlines Logo
5:43 pm - 6:07 pm
GSP
-
DTW
24h 24m
2 stops
$272Multiple Airlines
Mon, Apr 20 - Mon, Apr 27
Multiple Airlines Logo
6:05 am - 7:38 pm
DTW
-
GSP
13h 33m
2 stops
Multiple Airlines Logo
5:43 pm - 11:46 pm
GSP
-
DTW
30h 03m
1 stop
$273Multiple Airlines
Fri, Apr 10 - Mon, Apr 13
Multiple Airlines Logo
11:48 am - 7:38 pm
DTW
-
GSP
7h 50m
1 stop
Multiple Airlines Logo
5:43 pm - 11:38 am
GSP
-
DTW
17h 55m
2 stops
$274Multiple Airlines
Mon, Apr 13 - Mon, Apr 20
Multiple Airlines Logo
6:10 am - 4:53 pm
DTW
-
GSP
10h 43m
1 stop
Multiple Airlines Logo
5:43 pm - 11:45 am
GSP
-
DTW
18h 02m
2 stops
$280Multiple Airlines
Mon, Apr 20 - Fri, Apr 24
Multiple Airlines Logo
6:10 am - 4:53 pm
DTW
-
GSP
10h 43m
1 stop
Multiple Airlines Logo
5:43 pm - 4:14 pm
GSP
-
DTW
22h 31m
2 stops
$284Multiple Airlines
Mon, Apr 20 - Fri, Apr 24
Multiple Airlines Logo
1:28 pm - 7:38 pm
DTW
-
GSP
6h 10m
1 stop
Multiple Airlines Logo
5:43 pm - 11:12 am
GSP
-
DTW
17h 29m
2 stops
$292Multiple Airlines
Mon, Apr 6 - Fri, Apr 10
Multiple Airlines Logo
5:05 am - 7:38 pm
DTW
-
GSP
14h 33m
1 stop
Multiple Airlines Logo
8:18 pm - 7:16 pm
GSP
-
DTW
22h 58m
2 stops
$310Multiple Airlines
Mon, Apr 6 - Fri, Apr 10

Delta flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Delta deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Delta
Jun 22
DTW8:30 amDetroit Metropolitan Wayne County
7h 43m
1 stop
GSP4:13 pmGreenville
Jun 29
GSP3:42 pmGreenville
17h 42m
1 stop
DTW9:24 amDetroit Metropolitan Wayne County
$367
Delta
Jun 22
DTW7:30 amDetroit Metropolitan Wayne County
13h 55m
1 stop
GSP9:25 pmGreenville
Jun 30
GSP11:10 amGreenville
1h 47m
DTW12:57 pmDetroit Metropolitan Wayne County
$403
Delta
Apr 6
DTW8:20 pmDetroit Metropolitan Wayne County
1h 45m
GSP10:05 pmGreenville
Apr 13
GSP6:26 pmGreenville
1h 47m
DTW8:13 pmDetroit Metropolitan Wayne County
$509

Southwest flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Southwest deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Southwest
Apr 28
DTW1:40 pmDetroit Metropolitan Wayne County
8h 00m
2 stops
GSP9:40 pmGreenville
Apr 30
GSP6:25 pmGreenville
3h 55m
1 stop
DTW10:20 pmDetroit Metropolitan Wayne County
$317
Southwest
Apr 29
DTW1:20 pmDetroit Metropolitan Wayne County
6h 40m
1 stop
GSP8:00 pmGreenville
May 1
GSP6:25 pmGreenville
3h 55m
1 stop
DTW10:20 pmDetroit Metropolitan Wayne County
$340
Southwest
Apr 29
DTW8:15 amDetroit Metropolitan Wayne County
8h 05m
2 stops
GSP4:20 pmGreenville
May 1
GSP6:25 pmGreenville
3h 55m
1 stop
DTW10:20 pmDetroit Metropolitan Wayne County
$346

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/6

1:28 pm-7:38 pm

1 stop6h 10m

Greenville

Fri 4/10

5:43 pm-12:39 am

1 stop6h 56m

$247

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/20

6:10 am-4:53 pm

1 stop10h 43m

Greenville

Mon 4/27

5:43 pm-6:07 pm

2 stops24h 24m

$262

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/6

5:05 am-7:38 pm

1 stop14h 33m

Greenville

Fri 4/10

5:43 pm-12:39 am

1 stop6h 56m

$270

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/20

6:10 am-4:53 pm

1 stop10h 43m

Greenville

Mon 4/27

5:43 pm-6:07 pm

2 stops24h 24m

$272

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Fri 4/10

6:05 am-7:38 pm

2 stops13h 33m

Greenville

Mon 4/13

5:43 pm-11:46 pm

1 stop30h 03m

$273

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/13

11:48 am-7:38 pm

1 stop7h 50m

Greenville

Mon 4/20

5:43 pm-11:38 am

2 stops17h 55m

$274

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/20

6:10 am-4:53 pm

1 stop10h 43m

Greenville

Fri 4/24

5:43 pm-11:45 am

2 stops18h 02m

$280

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/20

6:10 am-4:53 pm

1 stop10h 43m

Greenville

Fri 4/24

5:43 pm-4:14 pm

2 stops22h 31m

$284

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/6

1:28 pm-7:38 pm

1 stop6h 10m

Greenville

Fri 4/10

5:43 pm-11:12 am

2 stops17h 29m

$292

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 4/6

5:05 am-7:38 pm

1 stop14h 33m

Greenville

Fri 4/10

8:18 pm-7:16 pm

2 stops22h 58m

$310

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Thursday departure recently was $439. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $693. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Greenville during this time can be as low as $459. Flights to Greenville are more costly in the evening, with an average ticket price of $524. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit Metropolitan Wayne County to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit Metropolitan Wayne County - Greenville flight prices

What cabin class options are available on Detroit Metropolitan Wayne County to Greenville flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Greenville flights?

You could potentially save up to 38% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Greenville flight.

How have Detroit Metropolitan Wayne County Airport to Greenville flight prices changed over time?

As of March 2026, prices for Detroit Metropolitan Wayne County Airport to Greenville flights are approximately 9% cheaper when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Greenville (DTW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Greenville

Best Price Found

$333

Fastest flight time

1h 39m

Direct flights

Every day

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $333. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Greenville found on momondo in the last 72 hours is $419.
The fastest flight from Detroit Metropolitan Wayne County Airport to Greenville takes 1h 39m
Direct flights go from Detroit Metropolitan Wayne County Airport to Greenville every day.
There is 1 airport in Greenville. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP).
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Greenville by plane?

    The distance between Detroit Metropolitan Wayne County and Greenville is about 511.4 mi. By plane, this route typically takes 1h 39m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Greenville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Greenville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Greenville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $208Free CancellationRating
7.1
11,492 reviews
Search American Airlines flights
SouthwestPriceFrom $293Free CancellationRating
8.0
4,330 reviews
Search Southwest flights
DeltaPriceFrom $399Free CancellationRating
7.9
8,320 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Greenville

    Delta flies from Detroit Metropolitan Wayne County Airport to Greenville around 8 times per week, with 8,320 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Greenville in the last 72 hours was $399 (round-trip), much lower than the average airfare cost of $512 for Delta flights on this route.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Greenville?

Once all potential Detroit to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

An easier way to manage your Greenville trip

We make it super easy to schedule, organize and travel with friends or family. Trips is free — and available to use no matter where you book.
Start using Trips
Find my bookings

Get notified when prices go down

Daily price changes in your inbox - only with Price Alerts.
1 adult
Thu 4/23
Thu 4/30
By creating a price alert you accept our terms of use and privacy policy.

Find better results for your trip to the United States