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Cheap flights from Detroit Metropolitan Wayne County Airport to Greenville from $145

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
9:33 pm - 9:32 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
11h 59m2 stops Fort Lauderdale Tampa
Multiple Airlines Logo
8:52 pm - 11:25 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
26h 33m1 stop Tampa
$274Multiple Airlines
Wed, Dec 9 - Fri, Dec 11
Multiple Airlines Logo
9:33 pm - 8:13 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
10h 40m1 stop Fort Lauderdale
Multiple Airlines Logo
10:12 am - 11:11 amGSP  Greenville-DTW Detroit Metropolitan Wayne County
48h 59m2 stops Tampa Atlanta Hartsfield-Jackson
$300Multiple Airlines
Sun, Dec 6 - Sun, Dec 13
Multiple Airlines Logo
10:28 pm - 2:19 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
15h 51m2 stops Atlanta Hartsfield-Jackson Tampa
Multiple Airlines Logo
3:30 pm - 8:58 amGSP  Greenville-DTW Detroit Metropolitan Wayne County
17h 28m1 stop Fort Lauderdale
$343Multiple Airlines
Mon, Dec 28 - Mon, Jan 18
Multiple Airlines Logo
9:33 pm - 8:13 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
10h 40m1 stop Fort Lauderdale
Multiple Airlines Logo
4:02 pm - 10:57 amGSP  Greenville-DTW Detroit Metropolitan Wayne County
18h 55m1 stop Orlando
$345Multiple Airlines
Sun, Dec 6 - Sun, Dec 13
Southwest Logo
3:10 pm - 7:30 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
4h 20m1 stop Baltimore/Washington
Southwest Logo
8:25 am - 1:00 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
4h 35m1 stop Baltimore/Washington
$377Southwest
Sat, Dec 5 - Sat, Dec 12
Southwest Logo
10:50 am - 4:00 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
5h 10m1 stop Nashville Intl
Southwest Logo
8:25 am - 5:25 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
9h 00m2 stops Baltimore/Washington Lambert-St Louis
$382Southwest
Sat, Dec 5 - Sat, Dec 12
Southwest Logo
10:50 am - 7:30 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
8h 40m2 stops Nashville Intl Baltimore/Washington
Southwest Logo
8:25 am - 5:25 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
9h 00m2 stops Baltimore/Washington Lambert-St Louis
$387Southwest
Sat, Dec 5 - Sat, Dec 12
Delta Logo
4:02 pm - 5:56 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
1h 54mnonstop
Delta Logo
6:36 pm - 8:28 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
1h 52mnonstop
$451Delta
Thu, Dec 24 - Mon, Dec 28
Delta Logo
8:25 am - 10:11 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
1h 46mnonstop
Delta Logo
11:08 am - 12:54 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
1h 46mnonstop
$451Delta
Tue, Nov 24 - Sat, Nov 28
Delta Logo
4:35 pm - 6:30 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
1h 55mnonstop
Delta Logo
7:10 pm - 9:00 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
1h 50mnonstop
$451Delta
Fri, Dec 4 - Mon, Dec 7

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Southwest flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Southwest deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Southwest
Dec 5
DTW3:10 pmDetroit Metropolitan Wayne County
4h 20m
1 stop
GSP7:30 pmGreenville
Dec 12
GSP8:25 amGreenville
4h 35m
1 stop
DTW1:00 pmDetroit Metropolitan Wayne County
$377
Southwest
Dec 5
DTW10:50 amDetroit Metropolitan Wayne County
5h 10m
1 stop
GSP4:00 pmGreenville
Dec 12
GSP8:25 amGreenville
9h 00m
2 stops
DTW5:25 pmDetroit Metropolitan Wayne County
$382
Southwest
Dec 5
DTW10:50 amDetroit Metropolitan Wayne County
8h 40m
2 stops
GSP7:30 pmGreenville
Dec 12
GSP8:25 amGreenville
9h 00m
2 stops
DTW5:25 pmDetroit Metropolitan Wayne County
$387

Delta flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Delta deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Delta
Dec 24
DTW4:02 pmDetroit Metropolitan Wayne County
1h 54m
GSP5:56 pmGreenville
Dec 29
GSP7:21 amGreenville
1h 51m
DTW9:12 amDetroit Metropolitan Wayne County
$451
Delta
Nov 24
DTW7:49 pmDetroit Metropolitan Wayne County
1h 44m
GSP9:33 pmGreenville
Nov 28
GSP5:40 amGreenville
4h 45m
1 stop
DTW10:25 amDetroit Metropolitan Wayne County
$461
Delta
Nov 24
DTW8:25 amDetroit Metropolitan Wayne County
1h 46m
GSP10:11 amGreenville
Nov 30
GSP8:11 amGreenville
4h 53m
1 stop
DTW1:04 pmDetroit Metropolitan Wayne County
$471

momondo Fare Finder

 
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Greenville that are best for you.

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Route

Depart

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Price

Cheapest round-trip

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Wed 12/9

9:33 pm-9:32 am

2 stops11h 59m

Greenville

Fri 12/11

8:52 pm-11:25 pm

1 stop26h 33m

$274

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Sun 12/6

9:33 pm-8:13 am

1 stop10h 40m

Greenville

Sun 12/13

10:12 am-11:11 am

2 stops48h 59m

$300

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Mon 12/28

10:28 pm-2:19 pm

2 stops15h 51m

Greenville

Mon 1/18

3:30 pm-8:58 am

1 stop17h 28m

$343

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Sun 12/6

9:33 pm-8:13 am

1 stop10h 40m

Greenville

Sun 12/13

4:02 pm-10:57 am

1 stop18h 55m

$345

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Sat 12/5

3:10 pm-7:30 pm

1 stop4h 20m

Greenville

Sat 12/12

8:25 am-1:00 pm

1 stop4h 35m

$377

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Sat 12/5

10:50 am-4:00 pm

1 stop5h 10m

Greenville

Sat 12/12

8:25 am-5:25 pm

2 stops9h 00m

$382

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Sat 12/5

10:50 am-7:30 pm

2 stops8h 40m

Greenville

Sat 12/12

8:25 am-5:25 pm

2 stops9h 00m

$387

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Thu 12/24

4:02 pm-5:56 pm

Nonstop1h 54m

Greenville

Mon 12/28

6:36 pm-8:28 pm

Nonstop1h 52m

$451
Quickest round-trip

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Tue 11/24

8:25 am-10:11 am

Nonstop1h 46m

Greenville

Sat 11/28

11:08 am-12:54 pm

Nonstop1h 46m

$451

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Fri 12/4

4:35 pm-6:30 pm

Nonstop1h 55m

Greenville

Mon 12/7

7:10 pm-9:00 pm

Nonstop1h 50m

$451

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit Metropolitan Wayne County Airport and Greenville?

Prices are currently low for flights on this route.

Typical prices usually range from $419 to $483.
The lowest price recently found on this route was $274.

What is the cheapest month to fly to Greenville?

The month of August is another great option to travel to Greenville, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $399.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Wednesday is the cheapest day to fly to Greenville from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Wednesday departure recently was $447. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $779. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Greenville during this time can be as low as $449. Flights to Greenville are more costly in the afternoon, with an average ticket price of $507. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit Metropolitan Wayne County to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit Metropolitan Wayne County - Greenville flight prices

What cabin class options are available on Detroit Metropolitan Wayne County Airport to Greenville flights?

There are 3 cabin classes available to choose from on Detroit Metropolitan Wayne County Airport to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Greenville flights?

You could potentially save up to 22% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Greenville flight.

How have Detroit Metropolitan Wayne County Airport to Greenville flight prices changed over time?

As of November 2026, prices for Detroit Metropolitan Wayne County Airport to Greenville flights are approximately 52% more expensive when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Greenville (DTW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Greenville

Best Price Found

$145

Fastest flight time

1h 44m

Direct flights

Every day

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $145. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Greenville found on momondo in the last 72 hours is $274.
The fastest flight from Detroit Metropolitan Wayne County Airport to Greenville takes 1h 44m
Direct flights go from Detroit Metropolitan Wayne County Airport to Greenville every day.
There is 1 airport in Greenville. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP).
Search flight deals

Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to Greenville

  • How far is Detroit Metropolitan Wayne County to Greenville by plane?

    The distance between Detroit Metropolitan Wayne County and Greenville is about 511.4 mi. By plane, this route typically takes 1h 44m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Greenville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Greenville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Greenville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $271Free CancellationRating
8.0
4,218 reviews
Search Southwest flights
DeltaPriceFrom $399Free CancellationRating
7.8
8,700 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Greenville

    Delta flies from Detroit Metropolitan Wayne County Airport to Greenville around 3 times per week, with 8,700 momondo users rating the airline 7.8/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Greenville in the last 72 hours was $399 (round-trip), much lower than the average airfare cost of $480 for Delta flights on this route.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Greenwood
Simpsonville
Greer
Duncan
Seneca

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Greenville?

Once all potential Detroit to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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