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Cheap flights from Detroit Metropolitan Wayne County Airport to Greenville from $108

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Greenville departing on 6/30. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
11:00 am - 7:56 pm
DTW
-
GSP
8h 56m
1 stop
Multiple Airlines Logo
3:10 pm - 1:05 pm
GSP
-
DTW
21h 55m
2 stops
$266Multiple Airlines
Thu, Jul 23 - Mon, Jul 27
Multiple Airlines Logo
11:00 am - 7:56 pm
DTW
-
GSP
8h 56m
1 stop
Multiple Airlines Logo
12:06 pm - 1:07 pm
GSP
-
DTW
25h 01m
1 stop
$309Multiple Airlines
Thu, Jul 23 - Mon, Jul 27
Multiple Airlines Logo
5:38 pm - 7:57 am
DTW
-
GSP
14h 19m
2 stops
Multiple Airlines Logo
8:37 am - 1:07 pm
GSP
-
DTW
28h 30m
1 stop
$313Multiple Airlines
Wed, Jul 1 - Sun, Jul 5
Multiple Airlines Logo
7:25 pm - 8:45 am
DTW
-
GSP
13h 20m
1 stop
Multiple Airlines Logo
12:11 pm - 1:07 pm
GSP
-
DTW
24h 56m
1 stop
$320Multiple Airlines
Thu, Sep 10 - Mon, Sep 14
Multiple Airlines Logo
11:00 am - 5:39 pm
DTW
-
GSP
6h 39m
1 stop
Multiple Airlines Logo
3:43 pm - 11:47 am
GSP
-
DTW
20h 04m
1 stop
$327Multiple Airlines
Fri, Aug 21 - Sun, Aug 23
Multiple Airlines Logo
5:38 pm - 3:06 pm
DTW
-
GSP
21h 28m
2 stops
Multiple Airlines Logo
3:35 pm - 1:07 pm
GSP
-
DTW
21h 32m
1 stop
$334Multiple Airlines
Mon, Jul 6 - Sun, Jul 12
American Airlines Logo
10:03 am - 6:43 pm
DTW
-
GSP
8h 40m
1 stop
American Airlines Logo
12:54 pm - 10:44 pm
GSP
-
DTW
9h 50m
1 stop
$335American Airlines
Tue, Jun 9 - Tue, Jun 16
Multiple Airlines Logo
7:25 pm - 7:30 am
DTW
-
GSP
12h 05m
1 stop
Multiple Airlines Logo
3:51 pm - 7:03 pm
GSP
-
DTW
27h 12m
2 stops
$336Multiple Airlines
Thu, Jul 23 - Sun, Jul 26
Multiple Airlines Logo
11:00 am - 5:39 pm
DTW
-
GSP
6h 39m
1 stop
Multiple Airlines Logo
3:35 pm - 1:07 pm
GSP
-
DTW
21h 32m
1 stop
$340Multiple Airlines
Mon, Jul 6 - Sun, Jul 12
Multiple Airlines Logo
1:59 pm - 7:39 am
DTW
-
GSP
17h 40m
2 stops
Multiple Airlines Logo
8:29 am - 11:47 am
GSP
-
DTW
27h 18m
1 stop
$345Multiple Airlines
Thu, Jun 4 - Mon, Jun 8

American Airlines flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
American Airlines
Jun 9
DTW10:03 amDetroit Metropolitan Wayne County
8h 40m
1 stop
GSP6:43 pmGreenville
Jun 16
GSP12:54 pmGreenville
9h 50m
1 stop
DTW10:44 pmDetroit Metropolitan Wayne County
$335
American Airlines
Aug 21
DTW4:25 pmDetroit Metropolitan Wayne County
6h 43m
1 stop
GSP11:08 pmGreenville
Aug 26
GSP6:27 amGreenville
10h 09m
1 stop
DTW4:36 pmDetroit Metropolitan Wayne County
$377
American Airlines
Jun 19
DTW7:58 pmDetroit Metropolitan Wayne County
3h 54m
1 stop
GSP11:52 pmGreenville
Jun 23
GSP12:54 pmGreenville
9h 50m
1 stop
DTW10:44 pmDetroit Metropolitan Wayne County
$382

Southwest flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Southwest deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Southwest
Jun 9
DTW6:40 amDetroit Metropolitan Wayne County
5h 35m
1 stop
GSP12:15 pmGreenville
Jun 16
GSP7:00 amGreenville
5h 45m
1 stop
DTW12:45 pmDetroit Metropolitan Wayne County
$371
Southwest
Jun 3
DTW6:10 amDetroit Metropolitan Wayne County
6h 00m
1 stop
GSP12:10 pmGreenville
Jun 6
GSP6:55 amGreenville
5h 45m
1 stop
DTW12:40 pmDetroit Metropolitan Wayne County
$373
Southwest
Jun 4
DTW6:30 amDetroit Metropolitan Wayne County
5h 45m
1 stop
GSP12:15 pmGreenville
Jun 8
GSP6:50 pmGreenville
5h 15m
1 stop
DTW12:05 amDetroit Metropolitan Wayne County
$375

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated May 10, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 7/23

11:00 am-7:56 pm

1 stop8h 56m

Greenville

Mon 7/27

3:10 pm-1:05 pm

2 stops21h 55m

$266

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 7/23

11:00 am-7:56 pm

1 stop8h 56m

Greenville

Mon 7/27

12:06 pm-1:07 pm

1 stop25h 01m

$309

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 7/1

5:38 pm-7:57 am

2 stops14h 19m

Greenville

Sun 7/5

8:37 am-1:07 pm

1 stop28h 30m

$313

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 9/10

7:25 pm-8:45 am

1 stop13h 20m

Greenville

Mon 9/14

12:11 pm-1:07 pm

1 stop24h 56m

$320

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Fri 8/21

11:00 am-5:39 pm

1 stop6h 39m

Greenville

Sun 8/23

3:43 pm-11:47 am

1 stop20h 04m

$327

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 7/6

5:38 pm-3:06 pm

2 stops21h 28m

Greenville

Sun 7/12

3:35 pm-1:07 pm

1 stop21h 32m

$334
Quickest round-trip

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Tue 6/9

10:03 am-6:43 pm

1 stop8h 40m

Greenville

Tue 6/16

12:54 pm-10:44 pm

1 stop9h 50m

$335

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 7/23

7:25 pm-7:30 am

1 stop12h 05m

Greenville

Sun 7/26

3:51 pm-7:03 pm

2 stops27h 12m

$336

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 7/6

11:00 am-5:39 pm

1 stop6h 39m

Greenville

Sun 7/12

3:35 pm-1:07 pm

1 stop21h 32m

$340

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 6/4

1:59 pm-7:39 am

2 stops17h 40m

Greenville

Mon 6/8

8:29 am-11:47 am

1 stop27h 18m

$345

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit Metropolitan Wayne County Airport and Greenville?

What is the cheapest month to fly to Greenville?

The month of July is another great option to travel to Greenville, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $399.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Saturday is the cheapest day to fly to Greenville from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Saturday departure recently was $449. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $737. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Greenville during this time can be as low as $469. Flights to Greenville are more costly in the evening, with an average ticket price of $549. Departure times in the evening fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit Metropolitan Wayne County to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit Metropolitan Wayne County - Greenville flight prices

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Greenville flights?

You could potentially save up to 8% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Greenville flight.

How have Detroit Metropolitan Wayne County Airport to Greenville flight prices changed over time?

As of May 2026, prices for Detroit Metropolitan Wayne County Airport to Greenville flights are approximately 31% cheaper when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Greenville (DTW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Greenville

Best Price Found

$333

Fastest flight time

1h 39m

Direct flights

Every day

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $333. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Greenville found on momondo in the last 72 hours is $509.
The fastest flight from Detroit Metropolitan Wayne County Airport to Greenville takes 1h 39m
Direct flights go from Detroit Metropolitan Wayne County Airport to Greenville every day.
There is 1 airport in Greenville. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP).
Search flight deals

Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to Greenville

  • How far is Detroit Metropolitan Wayne County to Greenville by plane?

    The distance between Detroit Metropolitan Wayne County and Greenville is about 511.4 mi. By plane, this route typically takes 1h 39m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Greenville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Greenville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Greenville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $293Free CancellationRating
8.0
4,306 reviews
Search Southwest flights
DeltaPriceFrom $399Free CancellationRating
7.9
8,455 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Greenville

    Delta flies from Detroit Metropolitan Wayne County Airport to Greenville around 19 times per week, with 8,453 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Greenville in the last 72 hours was $399 (round-trip), much lower than the average airfare cost of $547 for Delta flights on this route.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Greer
Seneca
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Greenville?

Once all potential Detroit to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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