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Cheap flights from Detroit Metropolitan Wayne County Airport to Greenville from $120

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Greenville departing on 11/18. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Greenville

Cheap round-trip flights

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Multiple Airlines Logo
7:05 am - 8:44 pmDTW-GSP
13h 39m1 stop
Multiple Airlines Logo
8:03 pm - 4:57 pmGSP-DTW
20h 54m2 stops
$259Multiple Airlines
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Sun, Oct 26 - Fri, Oct 31
Multiple Airlines Logo
7:05 am - 8:44 pmDTW-GSP
13h 39m1 stop
Multiple Airlines Logo
8:03 pm - 10:47 amGSP-DTW
14h 44m1 stop
$268Multiple Airlines
Find Deal
Sun, Oct 26 - Fri, Oct 31
Multiple Airlines Logo
11:04 am - 7:23 pmDTW-GSP
8h 19m1 stop
Multiple Airlines Logo
8:03 pm - 4:48 pmGSP-DTW
20h 45m2 stops
$269Multiple Airlines
Find Deal
Mon, Oct 20 - Mon, Oct 27
American Airlines Logo
8:00 am - 4:42 pmDTW-GSP
8h 42m1 stop
American Airlines Logo
7:45 am - 5:27 pmGSP-DTW
9h 42m1 stop
$321American Airlines
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Thu, Jan 8 - Tue, Jan 13
Southwest Logo
5:40 am - 10:00 amDTW-GSP
4h 20m1 stop
Southwest Logo
10:35 am - 2:45 pmGSP-DTW
4h 10m1 stop
$335Southwest
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Tue, Nov 18 - Wed, Nov 19
American Airlines Logo
1:08 pm - 11:59 pmDTW-GSP
10h 51m1 stop
American Airlines Logo
7:45 am - 5:19 pmGSP-DTW
9h 34m1 stop
$338American Airlines
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Wed, Jan 21 - Sat, Jan 24
Southwest Logo
5:40 am - 4:05 pmDTW-GSP
10h 25m2 stops
Southwest Logo
4:45 pm - 10:35 pmGSP-DTW
5h 50m1 stop
$340Southwest
Find Deal
Tue, Nov 18 - Wed, Nov 19
Delta Logo
8:00 pm - 9:46 pmDTW-GSP
1h 46mnonstop
Delta Logo
7:15 pm - 8:05 amGSP-DTW
12h 50m1 stop
$397Delta
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Sun, Dec 21 - Mon, Dec 29
Delta Logo
8:59 am - 10:48 amDTW-GSP
1h 49mnonstop
Delta Logo
7:27 am - 9:17 amGSP-DTW
1h 50mnonstop
$399Delta
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Thu, Nov 6 - Sun, Nov 9
United Airlines Logo
6:00 am - 4:53 pmDTW-GSP
10h 53m1 stop
United Airlines Logo
12:30 pm - 8:19 pmGSP-DTW
7h 49m1 stop
$451United Airlines
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Tue, Oct 28 - Wed, Oct 29

American Airlines flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
American Airlines
Jan 8
DTW8:00 amDetroit Metropolitan Wayne County
8h 42m
1 stop
GSP4:42 pmGreenville
Jan 13
GSP7:45 amGreenville
9h 42m
1 stop
DTW5:27 pmDetroit Metropolitan Wayne County
$321
Find similar
American Airlines
Jan 21
DTW1:08 pmDetroit Metropolitan Wayne County
10h 51m
1 stop
GSP11:59 pmGreenville
Jan 24
GSP7:45 amGreenville
9h 34m
1 stop
DTW5:19 pmDetroit Metropolitan Wayne County
$338
Find similar
American Airlines
Dec 12
DTW9:40 amDetroit Metropolitan Wayne County
9h 29m
1 stop
GSP7:09 pmGreenville
Jan 13
GSP6:04 amGreenville
10h 46m
1 stop
DTW4:50 pmDetroit Metropolitan Wayne County
$341
Find similar

Southwest flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Southwest deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Southwest
Nov 18
DTW5:40 amDetroit Metropolitan Wayne County
4h 20m
1 stop
GSP10:00 amGreenville
Nov 19
GSP10:35 amGreenville
4h 10m
1 stop
DTW2:45 pmDetroit Metropolitan Wayne County
$335
Find similar
Southwest
Nov 18
DTW5:40 amDetroit Metropolitan Wayne County
10h 25m
2 stops
GSP4:05 pmGreenville
Nov 19
GSP4:45 pmGreenville
5h 50m
1 stop
DTW10:35 pmDetroit Metropolitan Wayne County
$340
Find similar
Southwest
Nov 18
DTW5:40 amDetroit Metropolitan Wayne County
10h 25m
2 stops
GSP4:05 pmGreenville
Nov 19
GSP7:40 amGreenville
10h 10m
2 stops
DTW5:50 pmDetroit Metropolitan Wayne County
$345
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated October 6, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Sun 10/26

7:05 am-8:44 pm

1 stop13h 39m

Greenville

Fri 10/31

8:03 pm-4:57 pm

2 stops20h 54m

$259

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Sun 10/26

7:05 am-8:44 pm

1 stop13h 39m

Greenville

Fri 10/31

8:03 pm-10:47 am

1 stop14h 44m

$268

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 10/20

11:04 am-7:23 pm

1 stop8h 19m

Greenville

Mon 10/27

8:03 pm-4:48 pm

2 stops20h 45m

$269

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 1/8

8:00 am-4:42 pm

1 stop8h 42m

Greenville

Tue 1/13

7:45 am-5:27 pm

1 stop9h 42m

$321

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Tue 11/18

5:40 am-10:00 am

1 stop4h 20m

Greenville

Wed 11/19

10:35 am-2:45 pm

1 stop4h 10m

$335

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Wed 1/21

1:08 pm-11:59 pm

1 stop10h 51m

Greenville

Sat 1/24

7:45 am-5:19 pm

1 stop9h 34m

$338

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Tue 11/18

5:40 am-4:05 pm

2 stops10h 25m

Greenville

Wed 11/19

4:45 pm-10:35 pm

1 stop5h 50m

$340

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Sun 12/21

8:00 pm-9:46 pm

Nonstop1h 46m

Greenville

Mon 12/29

7:15 pm-8:05 am

1 stop12h 50m

$397

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 11/6

8:59 am-10:48 am

Nonstop1h 49m

Greenville

Sun 11/9

7:27 am-9:17 am

Nonstop1h 50m

$399

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Tue 10/28

6:00 am-4:53 pm

1 stop10h 53m

Greenville

Wed 10/29

12:30 pm-8:19 pm

1 stop7h 49m

$451

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $404.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Thursday departure recently was $459. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $607. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the evening. Flights from Detroit Metropolitan Wayne County Airport to Greenville during this time can be as low as $489. Flights to Greenville are more costly in the morning, with an average ticket price of $509. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit Metropolitan Wayne County to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit Metropolitan Wayne County - Greenville flight prices

How far in advance should I book a flight to Greenville?

You are more likely to see cheaper flights to Greenville from Detroit Metropolitan Wayne County Airport when booking weeks ahead of your departure date. In general, you can expect to find flights to Greenville for around $464 when searching weeks out. However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Greenville from Detroit Metropolitan Wayne County Airport for as low as $350 on momondo.

What cabin class options are available on Detroit Metropolitan Wayne County to Greenville flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Greenville flights?

You could potentially save up to 5% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Greenville flight.

How have Detroit Metropolitan Wayne County Airport to Greenville flight prices changed over time?

As of October 2025, prices for Detroit Metropolitan Wayne County Airport to Greenville flights are approximately 150% more expensive when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Greenville (DTW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Greenville

Best Price Found

$333

Fastest flight time

1h 36m

Direct flights

Mon, Wed, Thu, Fri, Sat and Sun

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $333. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Greenville found on momondo in the last 72 hours is $439.
The fastest flight from Detroit Metropolitan Wayne County Airport to Greenville takes 1h 36m
Direct flights go from Detroit Metropolitan Wayne County Airport to Greenville on Monday, Wednesday, Thursday, Friday, Saturday and Sunday. The only airline offering direct flights is Delta.
There is 1 airport near Greenville: Greenville (GSP)
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Greenville by plane?

    The distance between Detroit Metropolitan Wayne County and Greenville is about 511.4 mi. By plane, this route typically takes 1h 46m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Greenville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Greenville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Greenville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $236Free CancellationRating
7.2
11,040 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
8.0
4,232 reviews
Search Southwest flights
DeltaPriceFrom $397Free CancellationRating
7.9
7,967 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Greenville

    Delta flies from Detroit Metropolitan Wayne County Airport to Greenville around 17 times per week, with 7,967 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Greenville in the last 72 hours was $397 (round-trip), much lower than the average airfare cost of $497 for Delta flights on this route.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Greenville?

Once all potential Detroit to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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