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Cheap flights from Detroit Metropolitan Wayne County Airport to Greenville from $121

1 adult
1 adult, Economy, 0 bags

Discover deals from 900+ travel sites with momondo.

Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
8:41 pm - 3:29 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
18h 48m1 stop Tampa
Multiple Airlines Logo
8:52 pm - 10:45 amGSP  Greenville-DTW Detroit Metropolitan Wayne County
13h 53m1 stop Tampa
$246Multiple Airlines
Mon, Nov 9 - Fri, Nov 13
Multiple Airlines Logo
4:29 pm - 8:51 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
16h 22m1 stop Fort Lauderdale
Multiple Airlines Logo
8:32 pm - 11:40 amGSP  Greenville-DTW Detroit Metropolitan Wayne County
15h 08m1 stop Orlando
$260Multiple Airlines
Thu, Nov 12 - Mon, Nov 16
Multiple Airlines Logo
4:29 pm - 8:51 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
16h 22m1 stop Fort Lauderdale
Multiple Airlines Logo
8:52 pm - 11:37 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
26h 45m2 stops Tampa Fort Lauderdale
$262Multiple Airlines
Thu, Nov 12 - Mon, Nov 16
Multiple Airlines Logo
9:07 pm - 3:47 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
18h 40m1 stop Orlando
Multiple Airlines Logo
8:52 pm - 11:37 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
26h 45m2 stops Tampa Fort Lauderdale
$263Multiple Airlines
Thu, Oct 29 - Mon, Nov 2
Southwest Logo
5:45 am - 10:45 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
5h 00m1 stop Baltimore/Washington
Southwest Logo
8:30 am - 12:30 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
4h 00m1 stop Baltimore/Washington
$377Southwest
Sat, Oct 24 - Tue, Oct 27
Southwest Logo
11:45 am - 4:10 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
4h 25m1 stop Nashville Intl
Southwest Logo
11:20 am - 6:00 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
6h 40m1 stop Nashville Intl
$377Southwest
Thu, Nov 26 - Wed, Dec 2
Southwest Logo
5:30 am - 10:45 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
5h 15m1 stop Baltimore/Washington
Southwest Logo
11:20 am - 6:00 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
6h 40m1 stop Nashville Intl
$377Southwest
Mon, Nov 16 - Wed, Nov 18
Delta Logo
8:31 am - 10:20 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
1h 49mnonstop
Delta Logo
11:05 am - 12:52 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
1h 47mnonstop
$447Delta
Sun, Oct 11 - Wed, Oct 28
Delta Logo
7:45 pm - 9:27 pmDTW  Detroit Metropolitan Wayne County-GSP Greenville
1h 42mnonstop
Delta Logo
6:57 pm - 8:48 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
1h 51mnonstop
$447Delta
Tue, Oct 13 - Mon, Oct 19
Delta Logo
8:25 am - 10:11 amDTW  Detroit Metropolitan Wayne County-GSP Greenville
1h 46mnonstop
Delta Logo
7:10 pm - 9:00 pmGSP  Greenville-DTW Detroit Metropolitan Wayne County
1h 50mnonstop
$447Delta
Wed, Nov 25 - Sun, Dec 6

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American Airlines flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
American Airlines
Nov 7
DTW6:27 amDetroit Metropolitan Wayne County
10h 16m
1 stop
GSP4:43 pmGreenville
Nov 12
GSP6:53 amGreenville
9h 18m
1 stop
DTW4:11 pmDetroit Metropolitan Wayne County
$321
American Airlines
Oct 7
DTW1:10 pmDetroit Metropolitan Wayne County
7h 50m
1 stop
GSP9:00 pmGreenville
Oct 14
GSP7:23 amGreenville
9h 20m
1 stop
DTW4:43 pmDetroit Metropolitan Wayne County
$484
American Airlines
Oct 6
DTW7:31 amDetroit Metropolitan Wayne County
4h 00m
1 stop
GSP11:31 amGreenville
Oct 12
GSP4:10 pmGreenville
6h 31m
1 stop
DTW10:41 pmDetroit Metropolitan Wayne County
$486

Delta flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Delta deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Delta
Oct 9
DTW7:45 pmDetroit Metropolitan Wayne County
1h 42m
GSP9:27 pmGreenville
Oct 10
GSP7:20 amGreenville
1h 47m
DTW9:07 amDetroit Metropolitan Wayne County
$453
Delta
Oct 9
DTW7:45 pmDetroit Metropolitan Wayne County
1h 42m
GSP9:27 pmGreenville
Oct 12
GSP5:40 amGreenville
5h 50m
1 stop
DTW11:30 amDetroit Metropolitan Wayne County
$463
Delta
Oct 7
DTW7:45 pmDetroit Metropolitan Wayne County
1h 42m
GSP9:27 pmGreenville
Oct 14
GSP11:05 amGreenville
1h 47m
DTW12:52 pmDetroit Metropolitan Wayne County
$466

momondo Fare Finder

 
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Greenville that are best for you.

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Route

Depart

Return

Price

Cheapest round-trip

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Mon 11/9

8:41 pm-3:29 pm

1 stop18h 48m

Greenville

Fri 11/13

8:52 pm-10:45 am

1 stop13h 53m

$246

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Thu 11/12

4:29 pm-8:51 am

1 stop16h 22m

Greenville

Mon 11/16

8:32 pm-11:40 am

1 stop15h 08m

$260

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Thu 11/12

4:29 pm-8:51 am

1 stop16h 22m

Greenville

Mon 11/16

8:52 pm-11:37 pm

2 stops26h 45m

$262

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Thu 10/29

9:07 pm-3:47 pm

1 stop18h 40m

Greenville

Mon 11/2

8:52 pm-11:37 pm

2 stops26h 45m

$263

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Sat 10/24

5:45 am-10:45 am

1 stop5h 00m

Greenville

Tue 10/27

8:30 am-12:30 pm

1 stop4h 00m

$377

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Thu 11/26

11:45 am-4:10 pm

1 stop4h 25m

Greenville

Wed 12/2

11:20 am-6:00 pm

1 stop6h 40m

$377

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Mon 11/16

5:30 am-10:45 am

1 stop5h 15m

Greenville

Wed 11/18

11:20 am-6:00 pm

1 stop6h 40m

$377

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Sun 10/11

8:31 am-10:20 am

Nonstop1h 49m

Greenville

Wed 10/28

11:05 am-12:52 pm

Nonstop1h 47m

$447
Quickest round-trip

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Tue 10/13

7:45 pm-9:27 pm

Nonstop1h 42m

Greenville

Mon 10/19

6:57 pm-8:48 pm

Nonstop1h 51m

$447

DetroitGreenville

DTW Detroit Metropolitan Wayne County - GSP Greenville

DTWGSP

Detroit Metropolitan Wayne County

Wed 11/25

8:25 am-10:11 am

Nonstop1h 46m

Greenville

Sun 12/6

7:10 pm-9:00 pm

Nonstop1h 50m

$447

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Detroit Metropolitan Wayne County Airport and Greenville?

Prices are currently low for flights on this route.

Typical prices usually range from $438 to $697.
The lowest price recently found on this route was $246.

What is the cheapest month to fly to Greenville?

The month of August is another great option to travel to Greenville, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $399.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Wednesday is the cheapest day to fly to Greenville from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Wednesday departure recently was $449. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $757. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Greenville during this time can be as low as $449. Flights to Greenville are more costly in the afternoon, with an average ticket price of $548. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit Metropolitan Wayne County to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit Metropolitan Wayne County - Greenville flight prices

What cabin class options are available on Detroit Metropolitan Wayne County Airport to Greenville flights?

There are 3 cabin classes available to choose from on Detroit Metropolitan Wayne County Airport to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Greenville flights?

You could potentially save up to 44% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Greenville flight.

How have Detroit Metropolitan Wayne County Airport to Greenville flight prices changed over time?

As of September 2026, prices for Detroit Metropolitan Wayne County Airport to Greenville flights are approximately 63% more expensive when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Greenville (DTW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Greenville

Best Price Found

$121

Fastest flight time

1h 41m

Direct flights

Every day

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $121. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Greenville found on momondo in the last 72 hours is $246.
The fastest flight from Detroit Metropolitan Wayne County Airport to Greenville takes 1h 41m
Direct flights go from Detroit Metropolitan Wayne County Airport to Greenville every day.
There is 1 airport in Greenville. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP).
Search flight deals

Frequently asked questions about flying from Detroit Metropolitan Wayne County Airport to Greenville

  • How far is Detroit Metropolitan Wayne County to Greenville by plane?

    The distance between Detroit Metropolitan Wayne County and Greenville is about 511.4 mi. By plane, this route typically takes 1h 41m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Greenville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Greenville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Greenville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
SouthwestPriceFrom $271Free CancellationRating
8.0
4,200 reviews
Search Southwest flights
DeltaPriceFrom $399Free CancellationRating
7.8
8,599 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Greenville

    Delta flies from Detroit Metropolitan Wayne County Airport to Greenville around 18 times per week, with 8,603 momondo users rating the airline 7.8/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Greenville in the last 72 hours was $399 (round-trip), much lower than the average airfare cost of $527 for Delta flights on this route.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Greenwood
Simpsonville
Greer
Duncan
Seneca

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Greenville?

Once all potential Detroit to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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