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Cheap flights from Detroit Metropolitan Wayne County Airport to Greenville from $98

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Detroit Metropolitan Wayne County Airport to Greenville departing on 1/15. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Detroit Metropolitan Wayne County Airport to Greenville

Cheap round-trip flights

Enter your travel dates to find the best prices.
Multiple Airlines Logo
7:00 am - 3:59 pm
DTW
-
GSP
8h 59m1 stop
Multiple Airlines Logo
4:39 pm - 10:54 am
GSP
-
DTW
18h 15m1 stop
$206Multiple Airlines
Mon, Jan 12 - Mon, Jan 19
Multiple Airlines Logo
3:12 pm - 8:58 am
DTW
-
GSP
17h 46m1 stop
Multiple Airlines Logo
6:45 pm - 11:39 am
GSP
-
DTW
40h 54m2 stops
$214Multiple Airlines
Thu, Jan 15 - Thu, Jan 22
Multiple Airlines Logo
3:12 pm - 8:58 am
DTW
-
GSP
17h 46m1 stop
Multiple Airlines Logo
6:45 pm - 10:08 pm
GSP
-
DTW
27h 23m2 stops
$219Multiple Airlines
Sun, Jan 18 - Sun, Jan 25
Multiple Airlines Logo
3:12 pm - 8:58 am
DTW
-
GSP
17h 46m1 stop
Multiple Airlines Logo
6:45 pm - 10:05 am
GSP
-
DTW
15h 20m1 stop
$221Multiple Airlines
Thu, Jan 15 - Thu, Jan 22
Multiple Airlines Logo
3:12 pm - 8:58 am
DTW
-
GSP
17h 46m1 stop
Multiple Airlines Logo
6:45 pm - 10:05 am
GSP
-
DTW
15h 20m1 stop
$223Multiple Airlines
Sun, Jan 18 - Sun, Jan 25
Multiple Airlines Logo
11:39 am - 8:07 pm
DTW
-
GSP
8h 28m1 stop
Multiple Airlines Logo
4:39 pm - 11:41 pm
GSP
-
DTW
7h 02m1 stop
$231Multiple Airlines
Fri, Jan 23 - Fri, Jan 30
Multiple Airlines Logo
3:12 pm - 8:58 am
DTW
-
GSP
17h 46m1 stop
Multiple Airlines Logo
4:55 pm - 11:55 pm
GSP
-
DTW
7h 00m1 stop
$232Multiple Airlines
Thu, Jan 15 - Sun, Jan 18
Multiple Airlines Logo
3:12 pm - 8:58 am
DTW
-
GSP
17h 46m1 stop
Multiple Airlines Logo
4:55 pm - 11:55 pm
GSP
-
DTW
7h 00m1 stop
$242Multiple Airlines
Thu, Jan 15 - Sun, Jan 18
Multiple Airlines Logo
7:00 am - 3:59 pm
DTW
-
GSP
8h 59m1 stop
Multiple Airlines Logo
4:07 pm - 1:30 pm
GSP
-
DTW
21h 23m2 stops
$243Multiple Airlines
Mon, Jan 12 - Mon, Jan 19
Multiple Airlines Logo
11:39 am - 8:07 pm
DTW
-
GSP
8h 28m1 stop
Multiple Airlines Logo
4:39 pm - 7:41 am
GSP
-
DTW
15h 02m2 stops
$248Multiple Airlines
Fri, Jan 23 - Fri, Jan 30

American Airlines flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best American Airlines deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
American Airlines
Jan 14
DTW2:02 pmDetroit Metropolitan Wayne County
8h 14m
1 stop
GSP10:16 pmGreenville
Jan 21
GSP7:16 amGreenville
11h 43m
1 stop
DTW6:59 pmDetroit Metropolitan Wayne County
$311
Find similar
American Airlines
Jan 8
DTW2:02 pmDetroit Metropolitan Wayne County
8h 14m
1 stop
GSP10:16 pmGreenville
Jan 15
GSP12:37 pmGreenville
10h 08m
1 stop
DTW10:45 pmDetroit Metropolitan Wayne County
$337
Find similar
American Airlines
Jan 16
DTW2:02 pmDetroit Metropolitan Wayne County
8h 14m
1 stop
GSP10:16 pmGreenville
Jan 19
GSP12:37 pmGreenville
10h 08m
1 stop
DTW10:45 pmDetroit Metropolitan Wayne County
$346
Find similar

Delta flights from Detroit Metropolitan Wayne County Airport to Greenville

Our best Delta deals on Detroit Metropolitan Wayne County Airport to Greenville flight tickets
Delta
Mar 27
DTW3:50 pmDetroit Metropolitan Wayne County
1h 39m
GSP5:29 pmGreenville
Apr 1
GSP11:36 amGreenville
10h 41m
1 stop
DTW10:17 pmDetroit Metropolitan Wayne County
$397
Find similar
Delta
Mar 27
DTW3:50 pmDetroit Metropolitan Wayne County
1h 39m
GSP5:29 pmGreenville
Apr 3
GSP6:14 pmGreenville
1h 51m
DTW8:05 pmDetroit Metropolitan Wayne County
$399
Find similar
Delta
May 1
DTW3:55 pmDetroit Metropolitan Wayne County
5h 30m
1 stop
GSP9:25 pmGreenville
May 3
GSP6:20 pmGreenville
1h 49m
DTW8:09 pmDetroit Metropolitan Wayne County
$409
Find similar

momondo Fare Finder

 
Customize your flight search to find flights from Detroit Metropolitan Wayne County Airport to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, momondo users made 832,500 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Greenville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 1/12

7:00 am-3:59 pm

1 stop8h 59m

Greenville

Mon 1/19

4:39 pm-10:54 am

1 stop18h 15m

$206

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 1/15

3:12 pm-8:58 am

1 stop17h 46m

Greenville

Thu 1/22

6:45 pm-11:39 am

2 stops40h 54m

$214

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Sun 1/18

3:12 pm-8:58 am

1 stop17h 46m

Greenville

Sun 1/25

6:45 pm-10:08 pm

2 stops27h 23m

$219

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 1/15

3:12 pm-8:58 am

1 stop17h 46m

Greenville

Thu 1/22

6:45 pm-10:05 am

1 stop15h 20m

$221

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Sun 1/18

3:12 pm-8:58 am

1 stop17h 46m

Greenville

Sun 1/25

6:45 pm-10:05 am

1 stop15h 20m

$223

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Fri 1/23

11:39 am-8:07 pm

1 stop8h 28m

Greenville

Fri 1/30

4:39 pm-11:41 pm

1 stop7h 02m

$231

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 1/15

3:12 pm-8:58 am

1 stop17h 46m

Greenville

Sun 1/18

4:55 pm-11:55 pm

1 stop7h 00m

$232

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Thu 1/15

3:12 pm-8:58 am

1 stop17h 46m

Greenville

Sun 1/18

4:55 pm-11:55 pm

1 stop7h 00m

$242

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Mon 1/12

7:00 am-3:59 pm

1 stop8h 59m

Greenville

Mon 1/19

4:07 pm-1:30 pm

2 stops21h 23m

$243

DetroitGreenville

DTW - GSP

DTWGSP

Detroit Metropolitan Wayne County

Fri 1/23

11:39 am-8:07 pm

1 stop8h 28m

Greenville

Fri 1/30

4:39 pm-7:41 am

2 stops15h 02m

$248

Flights are sorted by cheapest round-trip flights first.

Showing 1-10 of 20 resultsSorted by cheapest first
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See travel insights to Greenville from

How to get the cheapest flight ticket from Detroit Metropolitan Wayne County Airport to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Detroit Metropolitan Wayne County Airport averaging around $404.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Thursday is the cheapest day to fly to Greenville from Detroit Metropolitan Wayne County Airport. The lowest ticket price found for a Thursday departure recently was $459. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $699. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the morning. Flights from Detroit Metropolitan Wayne County Airport to Greenville during this time can be as low as $459. Flights to Greenville are more costly in the afternoon, with an average ticket price of $536. Departure times in the afternoon fall within the peak daily travel times, which is why tickets can be more expensive.

What is the cheapest Detroit Metropolitan Wayne County to Greenville flight route?

Fly from Detroit Metropolitan Wayne County to Greenville for the best Detroit Metropolitan Wayne County - Greenville flight prices

What cabin class options are available on Detroit Metropolitan Wayne County to Greenville flights?

There are 4 cabin classes available to choose from on Detroit Metropolitan Wayne County to Greenville flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Detroit Metropolitan Wayne County Airport to Greenville flights?

You could potentially save up to 46% on your flight if you consider stops on a Detroit Metropolitan Wayne County Airport to Greenville flight.

How have Detroit Metropolitan Wayne County Airport to Greenville flight prices changed over time?

As of December 2025, prices for Detroit Metropolitan Wayne County Airport to Greenville flights are approximately 91% more expensive when compared to flights at the same time last year.

When to book flights from Detroit Metropolitan Wayne County Airport to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Detroit Metropolitan Wayne County Airport to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Detroit Metropolitan Wayne County Airport to Greenville (DTW to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Detroit Metropolitan Wayne County Airport to Greenville

Best Price Found

$333

Fastest flight time

1h 39m

Direct flights

Every day

Airports in Greenville

1 airport
The best one-way flight to Greenville from Detroit Metropolitan Wayne County Airport in the past 72 hours is $333. The best round-trip flight deal from Detroit Metropolitan Wayne County Airport to Greenville found on momondo in the last 72 hours is $499.
The fastest flight from Detroit Metropolitan Wayne County Airport to Greenville takes 1h 39m
Direct flights go from Detroit Metropolitan Wayne County Airport to Greenville every day.
There is 1 airport in Greenville. From Detroit Metropolitan Wayne County Airport there are direct flights to Greenville (GSP).
Search flight deals

  • How far is Detroit Metropolitan Wayne County to Greenville by plane?

    The distance between Detroit Metropolitan Wayne County and Greenville is about 511.4 mi. By plane, this route typically takes 1h 39m.

  • When did momondo last update prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    Prices for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport are updated daily.

  • How many operators does momondo search for flights from Detroit Metropolitan Wayne County Airport to Greenville Airport?

  • How old do you have to be to fly from Detroit Metropolitan Wayne County Airport to Greenville Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Detroit Metropolitan Wayne County Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The travel and health documents required for your trip to Greenville Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Greenville Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular plane model from Detroit Metropolitan Wayne County Airport to Greenville?

  • What is the most popular airline from Detroit Metropolitan Wayne County Airport to Greenville?

Best airlines flying from Detroit Metropolitan Wayne County Airport to Greenville

Compare and see reviews for airlines that fly from Detroit Metropolitan Wayne County Airport to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $226Free CancellationRating
7.2
11,054 reviews
Search American Airlines flights
SouthwestPriceFrom $306Free CancellationRating
7.9
4,250 reviews
Search Southwest flights
DeltaPriceFrom $397Free CancellationRating
7.9
8,005 reviews
Search Delta flights

  • Delta Flights From Detroit Metropolitan Wayne County Airport to Greenville

    Delta flies from Detroit Metropolitan Wayne County Airport to Greenville around 12 times per week, with 8,005 momondo users rating the airline 7.9/10. The cheapest Delta deal from Detroit Metropolitan Wayne County Airport to Greenville in the last 72 hours was $397 (round-trip), much lower than the average airfare cost of $503 for Delta flights on this route.

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Detroit to Greenville?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Detroit to Greenville. momondo saves you time and could save you money on your trip.

Can I find flights from Detroit to Greenville with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Detroit to Greenville flights to just show those with flexible booking policies.

How can momondo help me find flights from Detroit to Greenville?

Once all potential Detroit to Greenville flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Detroit to Greenville right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Detroit to Greenville flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.

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